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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUCB2 Gene

protein-coding   GIFtS: 51
GCID: GC11P017229

nucleobindin 2
 Explore 12 diseases affiliated with
NUCB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NUCB2    

Aliases
for NUCB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Nucleobindin 21 2     Nucleobindin-21
NEFA1 2 3 5     Nucleobinding 22
Gastric Cancer Antigen Zg42 3     Prepronefastin1
DNA-Binding Protein NEFA2 3     Prepronesfatin3
Nesfatin-11     Prepronesfatin3

External Ids:    HGNC: 80441   Entrez Gene: 49252   Ensembl: ENSG000000700817   OMIM: 6080205   UniProtKB: P803033   

Export aliases for NUCB2 gene to outside databases

Previous GC identifers: GC11M018347 GC11P018224 GC11P017321 GC11P017262 GC11P017255 GC11P016982


Summaries
for NUCB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NUCB2:
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus,
and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding
domains. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: NUCB2_HUMAN, P80303
Function: Calcium-binding protein. May have a role in calcium homeostasis
Function: Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food
intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate
blood pressure through directly acting on peripheral arterial resistance (By similarity)

Gene Wiki entry for NUCB2


Genomic Views
for NUCB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUCB2 gene promoter:
         AML1a   Pax-5   SREBP-1c   HNF-4alpha2   NF-kappaB   SREBP-1b   HNF-4alpha1   PPAR-alpha   SREBP-1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NUCB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUCB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUCB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

NUCB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUCB2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P017229:  view genomic region     (about GC identifiers)

Start:
 17,229,700 bp from pter      End:
 17,371,521 bp from pter
Size:
 141,822 bases      Orientation:
 plus strand

Proteins
for NUCB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NUCB2_HUMAN, P80303 (See protein sequence)
Recommended Name: Nucleobindin-2 precursor  
Size: 420 amino acids; 50196 Da
Subcellular location: Golgi apparatus. Membrane; Peripheral membrane protein. Cytoplasm. Secreted. Endoplasmic
reticulum (By similarity). Nucleus envelope (By similarity). Note=Golgi retention is mediated by its N-terminal region
Subcellular location: Nesfatin-1: Secreted
Miscellaneous: NEFA stands for N=DNA-binding; EF=EF-hand; A=Acidic region
Secondary accessions: A8K642 D3DQX5 Q8NFT5
Alternative splicing: 2 isoforms:  P80303-1   P80303-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUCB2: NX_P80303

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P80303

    • NUCB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005004.1  
    ENSEMBL proteins: 
     ENSP00000431136   ENSP00000435160   ENSP00000433542   ENSP00000436215   ENSP00000435558  
     ENSP00000435968   ENSP00000320168   ENSP00000436455   ENSP00000431328   ENSP00000431334  
     ENSP00000433194   ENSP00000435787   ENSP00000432741   ENSP00000408702  

    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for NUCB2
    Uscn Proteins for NUCB2

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS7811391
    GO:0005634nucleus ----
    GO:0005640nuclear outer membrane IEA--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IEA--


    NUCB2 for ontologies           About GeneDecksing



    NUCB2 Antibody Products: 
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    Uscn ELISAs and CLIAs for NUCB2

    Protein Domains /
    Families
    for NUCB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NUCB2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P80303

    ProtoNet protein and cluster: P80303

    UniProtKB/Swiss-Prot: NUCB2_HUMAN, P80303
    Similarity: Belongs to the nucleobindin family
    Similarity: Contains 2 EF-hand domains


    Function
    for NUCB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NUCB2_HUMAN, P80303
    Function: Calcium-binding protein. May have a role in calcium homeostasis
    Function: Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food
    intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate
    blood pressure through directly acting on peripheral arterial resistance (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUCB2
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    SwitchGear 3'UTR luciferase reporter plasmid: NUCB2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUCB2 (see all 7)
    OriGene shRNA RFP: NUCB2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUCB2

    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for NUCB2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUCB2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005164tumor necrosis factor receptor binding ----
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--


    NUCB2 for ontologies           About GeneDecksing


    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Nucb2):
     cardiovascular system  homeostasis/metabolism 

    NUCB2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NUCB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUCB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/21 Interacting proteins for NUCB2 (P803031, 2, 3 ENSP000003201684) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP3P425742, 3, ENSP000003110324MINT-6175556 I2D: score=1 STRING: ENSP00000311032
    CASP8Q147902, 3, ENSP000003512734MINT-6175525 I2D: score=1 STRING: ENSP00000351273
    CASP7P552102, 3MINT-6175536 I2D: score=1 
    CASP6P552122, 3, ENSP000002651644MINT-6175546 I2D: score=1 STRING: ENSP00000265164
    MLH1P406923, ENSP000002317904I2D: score=3 STRING: ENSP00000231790
    About this table

    Drugs & Compounds
    for NUCB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUCB2

    1 HMDB Compound for NUCB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about NUCB2 

    Transcripts
    for NUCB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NUCB2 gene: 
    NM_005013.2  

    Unigene Cluster for NUCB2:

    Nucleobindin 2
    Hs.654599  [show with all ESTs]
    Unigene Representative Sequence: AK128739
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000528644 ENST00000532658(uc001mmt.1 uc001mmv.1 uc001mmx.4)
    ENST00000530527(uc009ygw.1 uc001mms.1) ENST00000533773(uc001mmu.1)
    ENST00000526120 ENST00000533511 ENST00000533738(uc009ygx.1) ENST00000525637
    ENST00000531172 ENST00000323688(uc009ygy.1 uc009yha.3) ENST00000529010(uc001mmw.3 uc009ygz.3)
    ENST00000530964 ENST00000529313 ENST00000533926 ENST00000527580 ENST00000531242
    ENST00000527735 ENST00000532240(uc001mmy.1)

    miRNA
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUCB2 (see all 7)
    OriGene shRNA RFP: NUCB2
    OriGene siRNA: NUCB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUCB2
    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUCB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NUCB2

    Additional cDNA sequence: 

    AB231311.1 AF052642.1 AF052643.1 AF052644.1 AF450266.1 AK093209.1 AK096475.1 AK097398.1 
    AK128739.1 AK291507.1 BC111556.1 EU039831.1 EU039832.1 EU039833.1 X76732.1 

    11 DOTS entries:

    DT.414476  DT.95129910  DT.120733477  DT.95374531  DT.120733485  DT.120733490  DT.92445778  DT.100664608 
    DT.120733503  DT.92445784  DT.102836417 

    24/185 AceView cDNA sequences (see all 185):

    CA868576 AF052643 CB160901 AF052642 BM840165 BM968230 AI659640 CA867819 
    AA356817 BE463426 AW293374 AK096475 BU674607 BX955551 W45440 AI625785 
    AK093209 CA425855 BU619325 BM850306 CA429832 BM129213 CA430640 AF052644 

    GeneLoc Exon Structure


    Expression
    for NUCB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUCB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATCAACTGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NUCB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NUCB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUCB2

    SOURCE GeneReport for Unigene cluster: Hs.654599

    UniProtKB/Swiss-Prot: NUCB2_HUMAN, P80303
    Tissue specificity: Predominantly expressed in spleen, testis and normal stomach

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    In Situ
    Assay Products:     
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    Orthologs
    for NUCB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NUCB2 gene from 5/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NUCB21 nucleobindin 2 79.82(n)
    83.97(a)    		   423071  NM_001006468.1  NP_001006468.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NUCB26
    		 --
    		 74(a)
    		 1 ↔ 1
    		 1(66727747-66748524)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.852 Danio rerio mRNA similar to nucleobindin 2 (cDNA clone more 74.5(n)    BC046077.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta NUCB11 CG32190-PA 50.2(n)
    46.13(a)    		   39978  NM_140751.3  NP_649008.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea nucb-11 Protein NUCB-1 52.71(n)
    39.6(a)    		   181230  NM_171970.3  NP_741886.1 


    ENSEMBL Gene Tree for NUCB2 (if available)
    TreeFam Gene Tree for NUCB2 (if available) 

    Paralogs
    for NUCB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUCB2 gene
    NUCB12  
    2 SIMAP similar genes for NUCB2 using alignment to 14 protein entries:     NUCB2_HUMAN (see all proteins):
    Nucb2    NUCB1

    NUCB2 for paralogs           About GeneDecksing



    Genomic Variants
    for NUCB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: NUCB2_HUMAN, P80303
    Polymorphism: Deletion of Gln-402 is frequent


    10/11 NCBI SNPs in NUCB2 are shown (see all 11)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs125752401,2
    		C,F,H,--17307511(+) ACACAC/TACAAA 1 -- int13Minor allele frequency- T:0.01NS EA 292
    rs1130974151,2
    		C,--17332191(+) GTCTCAA/-AAAAA 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1446261871,2
    		C,--17334559(+) GCCGA-/TTTTTT 1 -- int10--------
    rs1119052511,2
    		C,--17344310(+) TTTCA-/TCTGTGT 1 -- int11Minor allele frequency- TC:0.50CSA 2
    rs354914611,2
    		C--17344311(+) TTCAT-/CTGTGTT 1 -- int12Minor allele frequency- CT:0.25NA 4
    rs1474666951,2
    		C,--17346328(+) TTGTC-/TATTT 
     ATTTATT    TATTT     		1 -- int10--------
    rs561022561,2
    		----17310429(+) GTATA-/TACACA
                CACAC     		1 -- int10--------
    rs1398428981,2
    		----17346330(+) TTTAT-/TTTA  
                TTATT     		1 -- int10--------
    rs1998194101,2
    		----17346328(+) TTGTC-/TATT  
                TATTT     		1 -- int10--------
    rs342613551,2
    		----17307512(+) ACACA-/TACAAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for NUCB2 (17229700 - 17371521 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NUCB2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUCB2
    DNA2.0 Custom Variant and Variant Library Synthesis for NUCB2

    Disorders / Diseases
    for NUCB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NUCB2 for disorders           About GeneDecksing

    OMIM gene information: 608020    OMIM disorders: --

    12 diseases for NUCB2:    About MalaCards
    gastric cancer    usher syndrome    gestational diabetes    seizure disorder
    diabetes mellitus    seizures    scleroderma    gastritis
    pharyngitis    obesity    hepatitis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: NUCB2 (4 documents)

    Export disorders for NUCB2 gene to outside databases

    Publications
    for NUCB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUCB2 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with NUCB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein. (PubMed id 7811391)1, 2, 3 Barnikol-Watanabe S.... Hilschmann N. (1994)
    2. Troglitazone, a ligand of peroxisome proliferator-activated receptor- {gamma}, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene. (PubMed id 20427483)1, 2, 9 Yamada M.... Mori M. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Serological identification and expression analysis of gastric cancer-associated genes. (PubMed id 12087473)1, 2 Line A....Rees R.C. (2002)
    5. Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region. (PubMed id 11749975)1, 2 Nesselhut J....Hilschmann N. (2001)
    6. Assembly of a high-resolution map of the Acadian Usher syndrome region and localization of the nuclear EF-hand acidic gene. (PubMed id 9639681)1, 2 Deangelis M.M....Batzer M.A. (1998)
    7. [Influence of AML1 and AML1-ETO on transcriptional re gulation of nucb2 gene] (PubMed id 20030931)1, 9 Zou B....Wang K.K. (2009)
    8. Nucleobindin-2/nesfatin in the endocrine pancreas: di stribution and relationship to glycaemic state. (PubMed id 20032201)1, 9 Foo K.S....Broberger C. (2010)
    9. Modulation of nucleobindin-1 and nucleobindin-2 by caspases. (PubMed id 18154733)1, 9 Valencia C.A....Liu R. (2008)
    10. Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex. (PubMed id 16407280)1, 9 Islam A....Levine S.J. (2006)

    External Searches for NUCB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing NUCB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4925 HGNC: 8044 AceView: NUCB2 Ensembl:ENSG00000070081 euGenes: HUgn4925
    ECgene: NUCB2 H-InvDB: NUCB2

    Other Databases showing NUCB2 gene

    (According to HUGE)
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    Specialized Databases showing NUCB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUCB2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NUCB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NUCB2 gene:
    Search GeneIP for patents involving NUCB2

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