Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NUCB2 Gene

Aliases for NUCB2 Gene

  • Nucleobindin 2 2 3 5
  • Gastric Cancer Antigen Zg4 3 4
  • DNA-Binding Protein NEFA 3 4
  • Prepronesfatin 3 4
  • NEFA 3 4
  • Epididymis Secretory Protein Li 109 3
  • Nucleobinding 2 3
  • Prepronefastin 3
  • Nesfatin 1 3
  • Nesfatin-1 3
  • HEL-S-109 3

External Ids for NUCB2 Gene

Previous GeneCards Identifiers for NUCB2 Gene

  • GC11M018347
  • GC11P018224
  • GC11P017321
  • GC11P017262
  • GC11P017255
  • GC11P016982

Summaries for NUCB2 Gene

Entrez Gene Summary for NUCB2 Gene

  • This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

GeneCards Summary for NUCB2 Gene

NUCB2 (Nucleobindin 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NUCB1.

UniProtKB/Swiss-Prot for NUCB2 Gene

  • Calcium-binding protein. May have a role in calcium homeostasis.

  • Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity).

Gene Wiki entry for NUCB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUCB2 Gene

Genomics for NUCB2 Gene

Regulatory Elements for NUCB2 Gene

Promoters for NUCB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUCB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUCB2 Gene

Chromosome:
11
Start:
17,208,153 bp from pter
End:
17,349,980 bp from pter
Size:
141,828 bases
Orientation:
Plus strand

Genomic View for NUCB2 Gene

Genes around NUCB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUCB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUCB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUCB2 Gene

Proteins for NUCB2 Gene

  • Protein details for NUCB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80303-NUCB2_HUMAN
    Recommended name:
    Nucleobindin-2
    Protein Accession:
    P80303
    Secondary Accessions:
    • A8K642
    • D3DQX5
    • Q8NFT5

    Protein attributes for NUCB2 Gene

    Size:
    420 amino acids
    Molecular mass:
    50196 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • NEFA stands for N=DNA-binding; EF=EF-hand; A=Acidic region.

    Alternative splice isoforms for NUCB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUCB2 Gene

Proteomics data for NUCB2 Gene at MOPED

Post-translational modifications for NUCB2 Gene

  • Ubiquitination at Lys 90 and Lys 247
  • Glycosylation at Ser 42, Ser 96, Thr 163, Thr 172, Thr 314, Thr 322, Tyr 389, and Ser 408
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for NUCB2 (Nesfatin-1/Nucleobindin-2)

No data available for DME Specific Peptides for NUCB2 Gene

Domains & Families for NUCB2 Gene

Gene Families for NUCB2 Gene

Protein Domains for NUCB2 Gene

Graphical View of Domain Structure for InterPro Entry

P80303

UniProtKB/Swiss-Prot:

NUCB2_HUMAN :
  • Contains 2 EF-hand domains.
  • Belongs to the nucleobindin family.
Domain:
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the nucleobindin family.
genes like me logo Genes that share domains with NUCB2: view

Function for NUCB2 Gene

Molecular function for NUCB2 Gene

UniProtKB/Swiss-Prot Function:
Calcium-binding protein. May have a role in calcium homeostasis.
UniProtKB/Swiss-Prot Function:
Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity).
genes like me logo Genes that share phenotypes with NUCB2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NUCB2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUCB2 Gene

Localization for NUCB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUCB2 Gene

Golgi apparatus. Membrane; Peripheral membrane protein. Cytoplasm. Secreted. Endoplasmic reticulum. Nucleus envelope. Note=Golgi retention is mediated by its N-terminal region.
Nesfatin-1: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUCB2 Gene COMPARTMENTS Subcellular localization image for NUCB2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytosol 4
endoplasmic reticulum 4
nucleus 4
plasma membrane 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA,IDA 16502470
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS 7811391
genes like me logo Genes that share ontologies with NUCB2: view

Pathways & Interactions for NUCB2 Gene

SuperPathways for NUCB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045599 negative regulation of fat cell differentiation IEA --
GO:0046627 negative regulation of insulin receptor signaling pathway IEA --
GO:0070093 negative regulation of glucagon secretion IEA --
genes like me logo Genes that share ontologies with NUCB2: view

No data available for Pathways by source and SIGNOR curated interactions for NUCB2 Gene

Drugs & Compounds for NUCB2 Gene

(1) Drugs for NUCB2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with NUCB2: view

Transcripts for NUCB2 Gene

Unigene Clusters for NUCB2 Gene

Nucleobindin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUCB2 Gene

No ASD Table

Relevant External Links for NUCB2 Gene

GeneLoc Exon Structure for
NUCB2
ECgene alternative splicing isoforms for
NUCB2

Expression for NUCB2 Gene

mRNA expression in normal human tissues for NUCB2 Gene

Protein differential expression in normal tissues from HIPED for NUCB2 Gene

This gene is overexpressed in Skin (23.8) and Salivary gland (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUCB2 Gene



SOURCE GeneReport for Unigene cluster for NUCB2 Gene Hs.654599

mRNA Expression by UniProt/SwissProt for NUCB2 Gene

P80303-NUCB2_HUMAN
Tissue specificity: Predominantly expressed in spleen, testis and normal stomach.
genes like me logo Genes that share expression patterns with NUCB2: view

Protein tissue co-expression partners for NUCB2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NUCB2 Gene

Orthologs for NUCB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUCB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUCB2 36
  • 100 (a)
OneToOne
NUCB2 35
  • 99.84 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia NUCB2 35
  • 91.73 (n)
  • 91.33 (a)
NUCB2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUCB2 36
  • 93 (a)
OneToOne
NUCB2 35
  • 93.24 (n)
  • 93.08 (a)
mouse
(Mus musculus)
Mammalia Nucb2 16
Nucb2 36
  • 86 (a)
OneToOne
Nucb2 35
  • 83.77 (n)
  • 86.16 (a)
oppossum
(Monodelphis domestica)
Mammalia NUCB2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUCB2 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nucb2 35
  • 83.85 (n)
  • 86.87 (a)
chicken
(Gallus gallus)
Aves NUCB2 35
  • 79.82 (n)
  • 83.97 (a)
NUCB2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUCB2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nucb2 35
  • 68.16 (n)
  • 73.13 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7060 35
zebrafish
(Danio rerio)
Actinopterygii nucb2a 36
  • 55 (a)
OneToMany
nucb2b 36
  • 63 (a)
OneToMany
Dr.85 35
nucb2a 35
  • 68.26 (n)
  • 71.11 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005608 35
  • 50.65 (n)
  • 45.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta NUCB1 35
  • 50.92 (n)
  • 46.38 (a)
NUCB1 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nucb-1 35
  • 53.69 (n)
  • 41.91 (a)
nucb-1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12858 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6711 36
  • 36 (a)
OneToMany
Species with no ortholog for NUCB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUCB2 Gene

ENSEMBL:
Gene Tree for NUCB2 (if available)
TreeFam:
Gene Tree for NUCB2 (if available)

Paralogs for NUCB2 Gene

Paralogs for NUCB2 Gene

genes like me logo Genes that share paralogs with NUCB2: view

Variants for NUCB2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NUCB2 Gene

P80303-NUCB2_HUMAN
Deletion of Gln-402 is frequent.

Sequence variations from dbSNP and Humsavar for NUCB2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs757081 - 17,330,136(-) TTGCT(C/G)ATCTA nc-transcript-variant, reference, missense
rs2521998 - 17,312,116(-) CCTCA(C/T)TCATT nc-transcript-variant, reference, missense
rs214070 -- 17,283,770(-) AACTT(A/T)TCTCT intron-variant
rs214075 -- 17,278,870(-) ACTTG(A/C)TTCTG intron-variant
rs214076 -- 17,278,710(-) AAGAC(A/G)TCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUCB2 Gene

Variant ID Type Subtype PubMed ID
nsv467711 CNV Gain 19166990
nsv469762 CNV Complex 16826518
nsv7692 CNV Insertion 18451855
nsv524611 CNV Loss 19592680
nsv897017 CNV Loss 21882294

Variation tolerance for NUCB2 Gene

Residual Variation Intolerance Score: 45.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.14; 95.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUCB2 Gene

HapMap Linkage Disequilibrium report
NUCB2
Human Gene Mutation Database (HGMD)
NUCB2

Disorders for NUCB2 Gene

Relevant External Links for NUCB2

Genetic Association Database (GAD)
NUCB2
Human Genome Epidemiology (HuGE) Navigator
NUCB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUCB2

No disorders were found for NUCB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUCB2 Gene

Publications for NUCB2 Gene

  1. Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein. (PMID: 7811391) Barnikol-Watanabe S. … Hilschmann N. (Biol. Chem. Hoppe-Seyler 1994) 2 3 4 67
  2. Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. (PMID: 20032201) Foo K.S. … Broberger C. (J. Endocrinol. 2010) 3 23
  3. Troglitazone, a ligand of peroxisome proliferator-activated receptor- gamma, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene. (PMID: 20427483) Yamada M. … Mori M. (Endocrinology 2010) 3 23
  4. [Influence of AML1 and AML1-ETO on transcriptional regulation of nucb2 gene]. (PMID: 20030931) Zou B. … Wang K.K. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009) 3 23
  5. Modulation of nucleobindin-1 and nucleobindin-2 by caspases. (PMID: 18154733) Valencia C.A. … Liu R. (FEBS Lett. 2008) 3 23

Products for NUCB2 Gene

Sources for NUCB2 Gene

Back to Top

Content