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Aliases for NUCB2 Gene

Aliases for NUCB2 Gene

  • Nucleobindin 2 2 3
  • NEFA 3 4 6
  • Gastric Cancer Antigen Zg4 3 4
  • DNA-Binding Protein NEFA 3 4
  • Prepronesfatin 3 4
  • Epididymis Secretory Protein Li 109 3
  • Nucleobinding 2 3
  • Nucleobindin-2 3
  • Prepronefastin 3
  • Nesfatin 1 3
  • Nesfatin-1 3
  • HEL-S-109 3

External Ids for NUCB2 Gene

Previous GeneCards Identifiers for NUCB2 Gene

  • GC11M018347
  • GC11P018224
  • GC11P017321
  • GC11P017262
  • GC11P017255
  • GC11P016982

Summaries for NUCB2 Gene

Entrez Gene Summary for NUCB2 Gene

  • This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

GeneCards Summary for NUCB2 Gene

NUCB2 (Nucleobindin 2) is a Protein Coding gene. Diseases associated with NUCB2 include seizure disorder. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NUCB1.

UniProtKB/Swiss-Prot for NUCB2 Gene

  • Calcium-binding protein. May have a role in calcium homeostasis

  • Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity).

Gene Wiki entry for NUCB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUCB2 Gene

Genomics for NUCB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUCB2 Gene

Start:
17,208,153 bp from pter
End:
17,349,974 bp from pter
Size:
141,822 bases
Orientation:
Plus strand

Genomic View for NUCB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUCB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUCB2 Gene

Proteins for NUCB2 Gene

  • Protein details for NUCB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80303-NUCB2_HUMAN
    Recommended name:
    Nucleobindin-2
    Protein Accession:
    P80303
    Secondary Accessions:
    • A8K642
    • D3DQX5
    • Q8NFT5

    Protein attributes for NUCB2 Gene

    Size:
    420 amino acids
    Molecular mass:
    50196 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • NEFA stands for N=DNA-binding; EF=EF-hand; A=Acidic region

    Alternative splice isoforms for NUCB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUCB2 Gene

Proteomics data for NUCB2 Gene at MOPED

Post-translational modifications for NUCB2 Gene

  • Ubiquitination at Lys90 and Lys247
  • Glycosylation at Ser42, Ser96, Thr163, Thr172, Thr314, Thr322, Tyr389, and Ser408
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for NUCB2 (Nesfatin-1/Nucleobindin-2)

No data available for DME Specific Peptides for NUCB2 Gene

Domains for NUCB2 Gene

Gene Families for NUCB2 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for NUCB2 Gene

Graphical View of Domain Structure for InterPro Entry

P80303

UniProtKB/Swiss-Prot:

NUCB2_HUMAN :
  • P80303
Domain:
  • Contains 2 EF-hand domains.
Family:
  • Belongs to the nucleobindin family.
genes like me logo Genes that share domains with NUCB2: view

Function for NUCB2 Gene

Molecular function for NUCB2 Gene

UniProtKB/Swiss-Prot Function: Calcium-binding protein. May have a role in calcium homeostasis
UniProtKB/Swiss-Prot Function: Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance (By similarity).

Gene Ontology (GO) - Molecular Function for NUCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with NUCB2: view

Phenotypes for NUCB2 Gene

genes like me logo Genes that share phenotypes with NUCB2: view

Animal Model Products

miRNA for NUCB2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUCB2 Gene

Localization for NUCB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUCB2 Gene

Golgi apparatus. Membrane; Peripheral membrane protein. Cytoplasm. Secreted. Endoplasmic reticulum. Nucleus envelope. Note=Golgi retention is mediated by its N-terminal region.
Nesfatin-1: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUCB2 Gene COMPARTMENTS Subcellular localization image for NUCB2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytosol 4
plasma membrane 4
endoplasmic reticulum 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for NUCB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus --
GO:0005635 nuclear envelope IEA --
GO:0005640 nuclear outer membrane --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with NUCB2: view

Pathways for NUCB2 Gene

SuperPathways for NUCB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUCB2 Gene

None

No data available for Pathways by source for NUCB2 Gene

Compounds for NUCB2 Gene

(1) HMDB Compounds for NUCB2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with NUCB2: view

Transcripts for NUCB2 Gene

Unigene Clusters for NUCB2 Gene

Nucleobindin 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUCB2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NUCB2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUCB2 Gene

No ASD Table

Relevant External Links for NUCB2 Gene

GeneLoc Exon Structure for
NUCB2
ECgene alternative splicing isoforms for
NUCB2

Expression for NUCB2 Gene

mRNA expression in normal human tissues for NUCB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUCB2 Gene

SOURCE GeneReport for Unigene cluster for NUCB2 Gene Hs.654599

mRNA Expression by UniProt/SwissProt for NUCB2 Gene

P80303-NUCB2_HUMAN
Tissue specificity: Predominantly expressed in spleen, testis and normal stomach.
genes like me logo Genes that share expressions with NUCB2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NUCB2 Gene

Orthologs for NUCB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUCB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUCB2 35
  • 99.84 (n)
  • 100 (a)
NUCB2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUCB2 35
  • 91.73 (n)
  • 91.33 (a)
NUCB2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUCB2 35
  • 93.24 (n)
  • 93.08 (a)
NUCB2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nucb2 35
  • 83.77 (n)
  • 86.16 (a)
Nucb2 16
Nucb2 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUCB2 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUCB2 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nucb2 35
  • 83.85 (n)
  • 86.87 (a)
chicken
(Gallus gallus)
Aves NUCB2 35
  • 79.82 (n)
  • 83.97 (a)
NUCB2 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUCB2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nucb2 35
  • 68.16 (n)
  • 73.13 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7060 35
zebrafish
(Danio rerio)
Actinopterygii Dr.85 35
nucb2a 35
  • 68.26 (n)
  • 71.11 (a)
nucb2a 36
  • 55 (a)
OneToMany
nucb2b 36
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005608 35
  • 50.65 (n)
  • 45.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta NUCB1 35
  • 50.92 (n)
  • 46.38 (a)
NUCB1 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nucb-1 35
  • 53.69 (n)
  • 41.91 (a)
nucb-1 36
  • 29 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12858 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6711 36
  • 36 (a)
OneToMany
Species with no ortholog for NUCB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUCB2 Gene

ENSEMBL:
Gene Tree for NUCB2 (if available)
TreeFam:
Gene Tree for NUCB2 (if available)

Paralogs for NUCB2 Gene

Paralogs for NUCB2 Gene

genes like me logo Genes that share paralogs with NUCB2: view

Variants for NUCB2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NUCB2 Gene

P80303-NUCB2_HUMAN
Deletion of Gln-402 is frequent

Sequence variations from dbSNP and Humsavar for NUCB2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1330 -- 17,294,482(-) TTTAT(A/G)CCAAT intron-variant
rs105290 -- 17,270,521(+) ccatg(C/T)cccac intron-variant
rs184190 -- 17,294,712(-) TCAAT(A/C/T)TAGCC intron-variant
rs186174 other 17,276,557(-) CCTGG(C/G/T)GGGAG upstream-variant-2KB, intron-variant
rs190046 -- 17,271,809(-) taccc(A/G)aaggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUCB2 Gene

Variant ID Type Subtype PubMed ID
nsv467711 CNV Gain 19166990
nsv469762 CNV Complex 16826518
nsv7692 CNV Insertion 18451855
nsv524611 CNV Loss 19592680
nsv897017 CNV Loss 21882294

Relevant External Links for NUCB2 Gene

HapMap Linkage Disequilibrium report
NUCB2
Human Gene Mutation Database (HGMD)
NUCB2

Disorders for NUCB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NUCB2 Gene including...

Search for NUCB2 Gene in MalaCards »

Relevant External Links for NUCB2

Genetic Association Database (GAD)
NUCB2
Human Genome Epidemiology (HuGE) Navigator
NUCB2
genes like me logo Genes that share disorders with NUCB2: view

No data available for UniProtKB/Swiss-Prot for NUCB2 Gene

Publications for NUCB2 Gene

  1. Troglitazone, a ligand of peroxisome proliferator-activated receptor- gamma, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene. (PMID: 20427483) Yamada M. … Mori M. (Endocrinology 2010) 3 4 23
  2. Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein. (PMID: 7811391) Barnikol-Watanabe S. … Hilschmann N. (Biol. Chem. Hoppe-Seyler 1994) 2 3 4
  3. Assembly of a high-resolution map of the Acadian Usher syndrome region and localization of the nuclear EF-hand acidic gene. (PMID: 9639681) Deangelis M.M. … Batzer M.A. (Biochim. Biophys. Acta 1998) 3 4
  4. Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region. (PMID: 11749975) Nesselhut J. … Hilschmann N. (FEBS Lett. 2001) 3 4
  5. Serological identification and expression analysis of gastric cancer- associated genes. (PMID: 12087473) Line A. … Rees R.C. (Br. J. Cancer 2002) 3 4

Products for NUCB2 Gene

Sources for NUCB2 Gene

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