Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NUCB2 Gene

protein-coding   GIFtS: 58
GCID: GC11P017229

Nucleobindin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nucleobindin 21 2     nesfatin-12
NEFA2 3 5     nucleobindin-22
Gastric Cancer Antigen Zg42 3     Nucleobinding 22
DNA-Binding Protein NEFA2 3     prepronefastin2
HEL-S-1092     prepronesfatin2
Epididymis Secretory Protein Li 1092     Prepronesfatin3

External Ids:    HGNC: 80441   Entrez Gene: 49252   Ensembl: ENSG000000700817   OMIM: 6080205   UniProtKB: P803033   

Export aliases for NUCB2 gene to outside databases

Previous GC identifers: GC11M018347 GC11P018224 GC11P017321 GC11P017262 GC11P017255 GC11P016982


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NUCB2 Gene:
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the
hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium
and has EF-folding domains. (provided by RefSeq, Oct 2011)

GeneCards Summary for NUCB2 Gene:
NUCB2 (nucleobindin 2) is a protein-coding gene. Diseases associated with NUCB2 include seizure disorder, and gestational diabetes. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NUCB1.

UniProtKB/Swiss-Prot: NUCB2_HUMAN, P80303
Function: Calcium-binding protein. May have a role in calcium homeostasis
Function: Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating
food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and
modulate blood pressure through directly acting on peripheral arterial resistance (By similarity)

Gene Wiki entry for NUCB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUCB2 gene promoter:
         AML1a   Pax-5   SREBP-1c   HNF-4alpha2   NF-kappaB   SREBP-1b   HNF-4alpha1   PPAR-alpha   SREBP-1a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUCB2 promoter sequence
   Search Chromatin IP Primers for NUCB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUCB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

NUCB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUCB2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P017229:  view genomic region     (about GC identifiers)

Start:
17,229,700 bp from pter      End:
17,371,521 bp from pter
Size:
141,822 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NUCB2_HUMAN, P80303 (See protein sequence)
Recommended Name: Nucleobindin-2 precursor  
Size: 420 amino acids; 50196 Da
Miscellaneous: NEFA stands for N=DNA-binding; EF=EF-hand; A=Acidic region
Secondary accessions: A8K642 D3DQX5 Q8NFT5
Alternative splicing: 2 isoforms:  P80303-1   P80303-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUCB2: NX_P80303

Explore proteomics data for NUCB2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys90, Lys247
  • Glycosylation2 at Ser42, Ser96, Thr163, Thr172, Thr314, Thr322, Tyr389, Ser408
  • Modification sites at PhosphoSitePlus

  • See NUCB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005004.1  
    ENSEMBL proteins: 
     ENSP00000431136   ENSP00000435160   ENSP00000433542   ENSP00000436215   ENSP00000435968  
     ENSP00000435558   ENSP00000320168   ENSP00000436455   ENSP00000431328   ENSP00000431334  
     ENSP00000433194   ENSP00000435787   ENSP00000432741   ENSP00000408702  

    NUCB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for NUCB2
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NUCB2
    GenScript Custom Purified and Recombinant Proteins Services for NUCB2
    Novus Biologicals NUCB2 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for NUCB2
    Cloud-Clone Corp. Proteins for NUCB2

    NUCB2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NUCB2 (Nesfatin-1/Nucleobindin-2)
    OriGene Antibodies for NUCB2
    OriGene Custom Antibody Services for NUCB2
    Novus Biologicals NUCB2 Antibodies
    Abcam antibodies for NUCB2
    Cloud-Clone Corp. Antibodies for NUCB2
    ThermoFisher Antibodies for NUCB2
    LSBio Antibodies in human, mouse, rat for NUCB2

    NUCB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NUCB2
    R&D Systems ELISAs for NUCB2 (Nesfatin-1/Nucleobindin-2)
    GenScript Custom Assay Services for NUCB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NUCB2
    Cloud-Clone Corp. CLIAs for NUCB2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR028813 NUCB2
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry P80303

    ProtoNet protein and cluster: P80303

    UniProtKB/Swiss-Prot: NUCB2_HUMAN, P80303
    Similarity: Belongs to the nucleobindin family
    Similarity: Contains 2 EF-hand domains


    NUCB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUCB2_HUMAN, P80303
    Function: Calcium-binding protein. May have a role in calcium homeostasis
    Function: Nesfatin-1: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating
    food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and
    modulate blood pressure through directly acting on peripheral arterial resistance (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
         
    NUCB2 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Nucb2):
     cardiovascular system  homeostasis/metabolism 

    NUCB2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUCB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NUCB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUCB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUCB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target NUCB2:
    hsa-mir-192-5p (MIRT026936), hsa-mir-193b-3p (MIRT016539), hsa-mir-215-5p (MIRT024896), hsa-mir-26b-5p (MIRT030199)

    Block miRNA regulation of human, mouse, rat NUCB2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NUCB2
    SwitchGear 3'UTR luciferase reporter plasmidNUCB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NUCB2
    Predesigned siRNA for gene silencing in human, mouse, rat NUCB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NUCB2

    Clone
    Products:
         
    OriGene clones in human, mouse for NUCB2 (see all 7)
    OriGene ORF clones in mouse, rat for NUCB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUCB2 (NM_005013)
    Sino Biological Human cDNA Clone for NUCB2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUCB2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NUCB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NUCB2
    Browse ESI BIO Cell Lines and PureStem Progenitors for NUCB2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUCB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NUCB2_HUMAN, P80303: Golgi apparatus. Membrane; Peripheral membrane protein. Cytoplasm. Secreted. Endoplasmic
    reticulum (By similarity). Nucleus envelope (By similarity). Note=Golgi retention is mediated by its N-terminal
    region
    NUCB2_HUMAN, P80303: Nesfatin-1: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus5
    cytosol4
    plasma membrane4
    endoplasmic reticulum2
    nucleus2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS7811391
    GO:0005634nucleus ----
    GO:0005640nuclear outer membrane IEA--
    GO:0005737cytoplasm ----
    GO:0005783endoplasmic reticulum IEA--

    NUCB2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUCB2
    Interactions:

        GeneGlobe Interaction Network for NUCB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for NUCB2 (P803031, 2, 3 ENSP000003201684) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CASP3P425742, 3, ENSP000003110324MINT-6175556 I2D: score=1 STRING: ENSP00000311032
    CASP8Q147902, 3, ENSP000003512734MINT-6175525 I2D: score=1 STRING: ENSP00000351273
    CASP7P552102, 3MINT-6175536 I2D: score=1 
    CASP6P552122, 3, ENSP000002651644MINT-6175546 I2D: score=1 STRING: ENSP00000265164
    MLH1P406923, ENSP000002317904I2D: score=3 STRING: ENSP00000231790
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUCB2

    1 HMDB Compound for NUCB2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NUCB2 gene: 
    NM_005013.2  

    Unigene Cluster for NUCB2:

    Nucleobindin 2
    Hs.654599  [show with all ESTs]
    Unigene Representative Sequence: AK128739
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000528644 ENST00000530527(uc009ygw.1 uc001mms.1) ENST00000533773(uc001mmu.1)
    ENST00000526120 ENST00000525637 ENST00000531172 ENST00000533511 ENST00000533738(uc009ygx.1)
    ENST00000323688(uc009ygy.1 uc009yha.3) ENST00000529010(uc001mmw.3 uc009ygz.3)
    ENST00000530964 ENST00000529313 ENST00000533926 ENST00000527580 ENST00000531242
    ENST00000527735 ENST00000532240(uc001mmy.1) ENST00000458064
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NUCB2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate NUCB2
    SwitchGear 3'UTR luciferase reporter plasmidNUCB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NUCB2
    Predesigned siRNA for gene silencing in human, mouse, rat NUCB2
    Clone
    Products:
         
    OriGene clones in human, mouse for NUCB2 (see all 7)
    OriGene ORF clones in mouse, rat for NUCB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUCB2 (NM_005013)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUCB2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NUCB2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NUCB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUCB2
      QuantiTect SYBR Green Assays in human, mouse, rat NUCB2
      QuantiFast Probe-based Assays in human, mouse, rat NUCB2

    Additional mRNA sequence: 

    AB231311.1 AF052642.1 AF052643.1 AF052644.1 AF450266.1 AK093209.1 AK096475.1 AK097398.1 
    AK128739.1 AK291507.1 BC111556.1 EU039831.1 EU039832.1 EU039833.1 X76732.1 

    11 DOTS entries:

    DT.414476  DT.95129910  DT.120733477  DT.95374531  DT.120733485  DT.120733490  DT.92445778  DT.100664608 
    DT.120733503  DT.92445784  DT.102836417 

    Selected AceView cDNA sequences (see all 185):

    AI625785 BX955551 CB160901 BU674607 AK096475 AW293374 CA867819 AI659640 
    BE463426 AA356817 BM840165 BM968230 AF052642 AF052643 CA868576 AF052644 
    W45440 BU619325 CA429832 AK093209 BM129213 CA430640 BM850306 CA425855 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NUCB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCAACTGGA
    NUCB2 Expression
    About this image


    NUCB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Ovary (Reproductive System)
             Oviduct
    NUCB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUCB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654599

    UniProtKB/Swiss-Prot: NUCB2_HUMAN, P80303
    Tissue specificity: Predominantly expressed in spleen, testis and normal stomach

        Custom PCR Arrays for NUCB2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NUCB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUCB2
    QuantiTect SYBR Green Assays in human, mouse, rat NUCB2
    QuantiFast Probe-based Assays in human, mouse, rat NUCB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUCB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NUCB2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nucb21 , 5 nucleobindin 21, 5 83.77(n)1
    86.16(a)1
      7 (61.79 cM)5
    533221  NM_001130479.21  NP_001123951.11 
     1165043695 
    chicken
    (Gallus gallus)
    Aves NUCB21 nucleobindin 2 79.82(n)
    83.97(a)
      423071  NM_001006468.1  NP_001006468.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUCB26
    nucleobindin 2
    72(a)
    1 ↔ 1
    1(66707614-66748533)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nucb21 nucleobindin 2 68.16(n)
    73.13(a)
      548541  NM_001015824.1  NP_001015824.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.852 Danio rerio mRNA similar to nucleobindin 2 (cDNA clone more 74.5(n)    BC046077.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NUCB11 NUCB1 50.92(n)
    46.38(a)
      39978  NM_140751.4  NP_649008.2 
    worm
    (Caenorhabditis elegans)
    Secernentea nucb-11 nucb-1 53.69(n)
    41.91(a)
      181230  NM_171970.4  NP_741886.1 


    ENSEMBL Gene Tree for NUCB2 (if available)
    TreeFam Gene Tree for NUCB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NUCB2 gene
    NUCB12  
    2 SIMAP similar genes for NUCB2 using alignment to 14 protein entries:     NUCB2_HUMAN (see all proteins):
    Nucb2    NUCB1

    NUCB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    NUCB2_HUMAN, P80303: Deletion of Gln-402 is frequent


    Selected SNPs for NUCB2 (see all 948)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1406598451,2
    --16980234(+) TTGGCA/GCTTTC 1 -- us2k10--------
    rs771322911,2
    F--16980249(+) CCTGCA/CTCAGT 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs2140911,2
    C,F,O,A,H--16980365(-) AAGGTT/GAGGCT 1 -- us2k120Minor allele frequency- G:0.24NS EA NA 1958
    rs1458324391,2
    --16980431(+) GGTGTG/TGTGGT 1 -- us2k10--------
    rs1384345081,2
    --16980445(+) CGCTTC/GTAATC 1 -- us2k10--------
    rs1809955021,2
    --16980475(+) CAGAGC/TGCTTG 1 -- us2k10--------
    rs1860734081,2
    --16980574(+) TGTGCC/TTGTAG 1 -- us2k10--------
    rs1402700671,2
    --16980579(+) TTGTAC/GTCCCA 1 -- us2k10--------
    rs1435025901,2
    C--16980811(+) TGCCAC/GTCACT 1 -- us2k10--------
    rs1909826381,2
    --16980930(+) GTTAGC/GGGCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NUCB2 (17229700 - 17371521 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for NUCB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7692CNV Insertion18451855
    nsv524611CNV Loss19592680
    nsv897017CNV Loss21882294
    nsv467711CNV Gain19166990
    nsv469762CNV Complex16826518

    Human Gene Mutation Database (HGMD): NUCB2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUCB2
    DNA2.0 Custom Variant and Variant Library Synthesis for NUCB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608020    OMIM disorders: --

    Selected diseases for NUCB2 (see all 21):    
    About MalaCards
    seizure disorder    gestational diabetes    usher syndrome    scleroderma
    gastritis    endotheliitis    anorexia nervosa    polycystic ovary syndrome
    fatty liver disease    diabetes mellitus    obesity    hypertension
    liver disease    tonsillitis    malaria    thyroiditis
    lung cancer    hepatitis    cerebritis    neuronitis


    NUCB2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUCB2
    Human Genome Epidemiology (HuGE) Navigator: NUCB2 (4 documents)

    Export disorders for NUCB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NUCB2 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with NUCB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein. (PubMed id 7811391)1, 2, 3 Barnikol-Watanabe S.... Hilschmann N. (Biol. Chem. Hoppe-Seyler 1994)
    2. Troglitazone, a ligand of peroxisome proliferator-activated receptor- gamma, stabilizes NUCB2 (Nesfatin) mRNA by activating the ERK1/2 pathway: isolation and characterization of the human NUCB2 gene. (PubMed id 20427483)1, 2, 9 Yamada M.... Mori M. (Endocrinology 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Serological identification and expression analysis of gastric cancer- associated genes. (PubMed id 12087473)1, 2 Line A.... Rees R.C. (Br. J. Cancer 2002)
    6. Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region. (PubMed id 11749975)1, 2 Nesselhut J.... Hilschmann N. (FEBS Lett. 2001)
    7. Assembly of a high-resolution map of the Acadian Usher syndrome region and localization of the nuclear EF-hand acidic gene. (PubMed id 9639681)1, 2 Deangelis M.M....Batzer M.A. (Biochim. Biophys. Acta 1998)
    8. [Influence of AML1 and AML1-ETO on transcriptional regulation of nucb2 gene]. (PubMed id 20030931)1, 9 Zou B....Wang K.K. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    9. Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state. (PubMed id 20032201)1, 9 Foo K.S....Broberger C. (J. Endocrinol. 2010)
    10. Modulation of nucleobindin-1 and nucleobindin-2 by caspases. (PubMed id 18154733)1, 9 Valencia C.A....Liu R. (FEBS Lett. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4925 HGNC: 8044 AceView: NUCB2 Ensembl:ENSG00000070081 euGenes: HUgn4925
    ECgene: NUCB2 H-InvDB: NUCB2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NUCB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NUCB2 gene:
    Search GeneIP for patents involving NUCB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for NUCB2 (Nesfatin-1/Nucleobindin-2)   Browse Cell Culture Products  
     ELISAs for NUCB2 (Nesfatin-1/Nucleobindin-2)   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NUCB2   OriGene RNAi products in human, mouse, rat for NUCB2  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NUCB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for NUCB2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NUCB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NUCB2   OriGene Custom Protein Services for NUCB2  

     
     
     Block miRNA regulation of human, mouse, rat NUCB2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NUCB2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUCB2 Predesigned siRNA for gene silencing in human, mouse, rat NUCB2
     QuantiFast Probe-based Assays in human, mouse, rat NUCB2 QuantiTect SYBR Green Assays in human, mouse, rat NUCB2
     Custom PCR Arrays for NUCB2 Search Chromatin IP Primers for NUCB2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUCB2  GeneGlobe Interaction Network for NUCB2
     Regulatory tfbs in NUCB2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NUCB2 GenScript cDNA clones with any tag delivered in your preferred vector for NUCB2
     GenScript Custom Assay Services for NUCB2 GenScript Custom overexpressing Cell Line Services for NUCB2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NUCB2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for NUCB2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for NUCB2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NUCB2 antibodies
     NUCB2 proteins
     Antibodies for NUCB2
     See all of Abcam's Antibodies, Kits and Proteins for NUCB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for NUCB2
     Proteins for NUCB2
     Antibodies for NUCB2
     ELISAs for NUCB2
     CLIAs for NUCB2



     Browse ESI BIO Cell Lines and PureStem Progenitors for NUCB2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUCB2
     SwitchGear 3'UTR luciferase reporter plasmids for NUCB2
     SwitchGear Promoter luciferase reporter plasmids for NUCB2
     ThermoFisher Antibodies for NUCB2
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NUCB2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUCB2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NUCB2
     LSBio Antibodies in human, mouse, rat for NUCB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NUCB2 gene at Home site.
    Version: 3.12.162 20 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4