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Aliases for NUCB1 Gene

Aliases for NUCB1 Gene

  • Nucleobindin 1 2 3
  • CALNUC 3 4
  • NUC 3 4
  • Nucleobindin-1 3

External Ids for NUCB1 Gene

Previous GeneCards Identifiers for NUCB1 Gene

  • GC19P050062
  • GC19P049772
  • GC19P054079
  • GC19P054095
  • GC19P049403
  • GC19P045779

Summaries for NUCB1 Gene

Entrez Gene Summary for NUCB1 Gene

  • This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010]

GeneCards Summary for NUCB1 Gene

NUCB1 (Nucleobindin 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is NUCB2.

UniProtKB/Swiss-Prot for NUCB1 Gene

  • Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity).

Gene Wiki entry for NUCB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUCB1 Gene

Genomics for NUCB1 Gene

Regulatory Elements for NUCB1 Gene

Genomic Location for NUCB1 Gene

48,900,050 bp from pter
48,923,372 bp from pter
23,323 bases
Plus strand

Genomic View for NUCB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUCB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUCB1 Gene

Proteins for NUCB1 Gene

  • Protein details for NUCB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RD64
    • Q15838
    • Q7Z4J7
    • Q9BUR1

    Protein attributes for NUCB1 Gene

    461 amino acids
    Molecular mass:
    53879 Da
    Quaternary structure:
    • Interacts with GNAI2 and GNAI3.
    • Discovered as DNA-binding protein in the serum of lupus-prone mice

    Three dimensional structures from OCA and Proteopedia for NUCB1 Gene

neXtProt entry for NUCB1 Gene

Proteomics data for NUCB1 Gene at MOPED

Post-translational modifications for NUCB1 Gene

  • O-glycosylated.
  • Glycosylation at Thr39, Thr42, Ser44, Thr47, Tyr50, Ser93, Thr148, Thr160, Thr162, Tyr168, Ser224, Thr313, Ser320, Thr321, Ser369, Thr372, Ser378, Thr426, and Ser444
  • Modification sites at PhosphoSitePlus

Other Protein References for NUCB1 Gene

Antibody Products

No data available for DME Specific Peptides for NUCB1 Gene

Domains for NUCB1 Gene

Gene Families for NUCB1 Gene

  • EFHAND :EF-hand domain containing

Protein Domains for NUCB1 Gene

Suggested Antigen Peptide Sequences for NUCB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q02818
  • The EF-hand domains are unfolded in the absence of Ca(2+) and fold upon Ca(2+) addition
  • Contains 2 EF-hand domains.
  • Belongs to the nucleobindin family.
genes like me logo Genes that share domains with NUCB1: view

Function for NUCB1 Gene

Molecular function for NUCB1 Gene

GENATLAS Biochemistry:
nucleobindin,55kDa,ubiquitously expressed,homolog of a secreted protein promoting production of DNA-specific antibodies in lupus-prone MRL/lpr mouse
UniProtKB/Swiss-Prot Function:
Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis (By similarity).

Gene Ontology (GO) - Molecular Function for NUCB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 24136289
genes like me logo Genes that share ontologies with NUCB1: view

Phenotypes for NUCB1 Gene

GenomeRNAi human phenotypes for NUCB1:
genes like me logo Genes that share phenotypes with NUCB1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUCB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUCB1 Gene

Localization for NUCB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUCB1 Gene

Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Lumenal side. Cytoplasm. Note=A small fraction of the protein may be cytoplasmic. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for NUCB1 Gene COMPARTMENTS Subcellular localization image for NUCB1 gene
Compartment Confidence
cytoskeleton 4
extracellular 4
golgi apparatus 4
endoplasmic reticulum 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NUCB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IDA --
GO:0015630 microtubule cytoskeleton IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NUCB1: view

Pathways for NUCB1 Gene

SuperPathways for NUCB1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for NUCB1 Gene

Gene Ontology (GO) - Biological Process for NUCB1 Gene


No data available for Pathways by source for NUCB1 Gene

Compounds for NUCB1 Gene

(1) HMDB Compounds for NUCB1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(2) Novoseek inferred chemical compound relationships for NUCB1 Gene

Compound -log(P) Hits PubMed IDs
leucine 57.6 4
calcium 10.5 8
genes like me logo Genes that share compounds with NUCB1: view

Transcripts for NUCB1 Gene

mRNA/cDNA for NUCB1 Gene

(13) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NUCB1 Gene

Nucleobindin 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUCB1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUCB1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6: - - - -

ExUns: 13a · 13b

Relevant External Links for NUCB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUCB1 Gene

mRNA expression in normal human tissues for NUCB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NUCB1 Gene

This gene is overexpressed in Lavage (13.5) and Amniocyte (12.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NUCB1 Gene

SOURCE GeneReport for Unigene cluster for NUCB1 Gene Hs.631602

mRNA Expression by UniProt/SwissProt for NUCB1 Gene

Tissue specificity: Expressed both in fetal and adult heart, lung, liver, kidney and brain, and in adult skeletal muscle, placenta and pancreas
genes like me logo Genes that share expressions with NUCB1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for NUCB1 Gene

Orthologs for NUCB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUCB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NUCB1 35
  • 89.51 (n)
  • 93.97 (a)
NUCB1 36
  • 90 (a)
(Canis familiaris)
Mammalia NUCB1 35
  • 89.86 (n)
  • 94.81 (a)
NUCB1 36
  • 87 (a)
(Mus musculus)
Mammalia Nucb1 35
  • 85.29 (n)
  • 88.25 (a)
Nucb1 16
Nucb1 36
  • 87 (a)
(Pan troglodytes)
Mammalia NUCB1 35
  • 95.73 (n)
  • 94.14 (a)
NUCB1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nucb1 35
  • 85.15 (n)
  • 87.97 (a)
(Monodelphis domestica)
Mammalia NUCB1 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia NUCB1 36
  • 75 (a)
(Anolis carolinensis)
Reptilia NUCB1 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nucb1 35
  • 69.02 (n)
  • 75.31 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23574 35
(Danio rerio)
Actinopterygii nucb1 35
  • 65.49 (n)
  • 67.93 (a)
nucb1 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta NUCB1 36
  • 28 (a)
(Caenorhabditis elegans)
Secernentea nucb-1 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6711 36
  • 35 (a)
Species with no ortholog for NUCB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUCB1 Gene

Gene Tree for NUCB1 (if available)
Gene Tree for NUCB1 (if available)

Paralogs for NUCB1 Gene

Paralogs for NUCB1 Gene

Selected SIMAP similar genes for NUCB1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NUCB1: view

Variants for NUCB1 Gene

Sequence variations from dbSNP and Humsavar for NUCB1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7028 -- 48,922,842(-) TGGCC(C/T)GGAGC utr-variant-3-prime
rs1058483 -- 48,904,403(+) GAGAC(A/G)GATGG synonymous-codon, reference
rs1058487 -- 48,921,295(+) GCCGC(C/T)TGGAG reference, synonymous-codon
rs1058491 -- 48,922,581(+) CCCAG(A/G)TCCAC utr-variant-3-prime
rs1058594 -- 48,923,064(+) GACCT(C/T)TTGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NUCB1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833855 CNV Loss 17160897
nsv912245 CNV Loss 21882294
dgv3969n71 CNV Gain 21882294
nsv833856 CNV Loss 17160897
nsv470148 CNV Gain 18288195
esv2670526 CNV Deletion 23128226
nsv138250 CNV Loss 16902084
nsv833857 CNV Loss 17160897
nsv518164 CNV Loss 19592680

Relevant External Links for NUCB1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUCB1 Gene

Disorders for NUCB1 Gene

(1) Novoseek inferred disease relationships for NUCB1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 4

Relevant External Links for NUCB1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with NUCB1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for NUCB1 Gene

Publications for NUCB1 Gene

  1. Organization of the human gene for nucleobindin (NUC) and its chromosomal assignment to 19q13.2-q13.4. (PMID: 8661046) Miura K. … Kurosawa Y. (Genomics 1996) 2 3 4 23
  2. Molecular cloning of nucleobindin, a novel DNA-binding protein that contains both a signal peptide and a leucine zipper structure. (PMID: 1520323) Miura K. … Kanai Y. (Biochem. Biophys. Res. Commun. 1992) 3 4 23
  3. A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site. (PMID: 19656946) Tsukumo Y. … Tomida A. (J. Biol. Chem. 2009) 3 23
  4. Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation. (PMID: 17686766) Tsukumo Y. … Tsuruo T. (J. Biol. Chem. 2007) 3 23
  5. Modulation of nucleobindin-1 and nucleobindin-2 by caspases. (PMID: 18154733) Valencia C.A. … Liu R. (FEBS Lett. 2008) 3 23

Products for NUCB1 Gene

Sources for NUCB1 Gene

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