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Aliases for NUBP2 Gene

Aliases for NUBP2 Gene

  • Nucleotide Binding Protein 2 2 3 5
  • Nucleotide Binding Protein 2 (MinD Homolog, E. Coli) 2 3
  • NBP 2 3 4
  • Homolog Of Yeast Cytosolic Fe-S Cluster Deficient 1 3
  • Nucleotide Binding Protein 2 (E.Coli MinD Like) 2
  • Cytosolic Fe-S Cluster Assembly Factor NUBP2 3
  • Nucleotide-Binding Protein 2 4
  • NUBP1 3
  • CFD1 3

External Ids for NUBP2 Gene

Previous GeneCards Identifiers for NUBP2 Gene

  • GC16P001850
  • GC16P001772
  • GC16P001832

Summaries for NUBP2 Gene

Entrez Gene Summary for NUBP2 Gene

  • This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

GeneCards Summary for NUBP2 Gene

NUBP2 (Nucleotide Binding Protein 2) is a Protein Coding gene. Diseases associated with NUBP2 include Autonomic Nervous System Neoplasm and Peripheral Nervous System Neoplasm. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. GO annotations related to this gene include nucleotide binding and 4 iron, 4 sulfur cluster binding.

UniProtKB/Swiss-Prot for NUBP2 Gene

  • Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.

Gene Wiki entry for NUBP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUBP2 Gene

Genomics for NUBP2 Gene

Regulatory Elements for NUBP2 Gene

Enhancers for NUBP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G002121 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.1 +342.7 342664 8.2 HDGF ATF1 PKNOX1 AGO1 SIN3A FEZF1 ZNF2 ZNF121 GLIS2 KLF7 ENSG00000261123 MLST8 ENSG00000261240 TSC2 NME3 DNASE1L2 NUBP2 NTHL1 SLC9A3R2 TBL3
GH16G001530 1.4 FANTOM5 ENCODE dbSUPER 2.3 -247.7 -247678 10.0 CTCF LEF1 TAF1 MAX ZIC2 ZNF2 RAD21 GATA3 ZFHX2 POLR2A TMEM204 TELO2 FAHD1 PTX4 IFT140 CCDC154 NME3 TSR3 FBXL16 CLCN7
GH16G001928 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.2 +146.8 146823 1.8 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 ZNF143 IFT140 CCDC154 ERVK13-1 FAHD1 EME2 NME3 JPT2 ENSG00000260447 SNHG19 HAGH
GH16G001777 1.2 ENCODE 0.7 -4.8 -4818 2.1 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 ZNF143 ZNF548 ZNF263 SP3 ENSG00000261505 HAGH ENSG00000261123 ENSG00000260646 SNORA64 ENSG00000260954 ENSG00000255513 ENSG00000260051 JPT2 LOC105371049
GH16G001781 1.1 ENCODE 0.7 -0.4 -430 2.9 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 SIN3A ARID4B DMAP1 FAHD1 EME2 HAGH NUBP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NUBP2 on UCSC Golden Path with GeneCards custom track

Promoters for NUBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082386 -101 2401 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 SIN3A ARID4B DMAP1

Genomic Location for NUBP2 Gene

Chromosome:
16
Start:
1,782,901 bp from pter
End:
1,789,191 bp from pter
Size:
6,291 bases
Orientation:
Plus strand

Genomic View for NUBP2 Gene

Genes around NUBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUBP2 Gene

Proteins for NUBP2 Gene

  • Protein details for NUBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y2-NUBP2_HUMAN
    Recommended name:
    Cytosolic Fe-S cluster assembly factor NUBP2
    Protein Accession:
    Q9Y5Y2
    Secondary Accessions:
    • D3DU80
    • Q9NWB2

    Protein attributes for NUBP2 Gene

    Size:
    271 amino acids
    Molecular mass:
    28825 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Heterotetramer of 2 NUBP1 and 2 NUBP2 chains (By similarity). Interacts with KIFC1 (By similarity). Interacts with NUBP1 (PubMed:18573874).

neXtProt entry for NUBP2 Gene

Post-translational modifications for NUBP2 Gene

  • Ubiquitination at Lys45 and posLast=9898
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUBP2 Gene

Domains & Families for NUBP2 Gene

Gene Families for NUBP2 Gene

Protein Domains for NUBP2 Gene

Suggested Antigen Peptide Sequences for NUBP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y2

UniProtKB/Swiss-Prot:

NUBP2_HUMAN :
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Family:
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
genes like me logo Genes that share domains with NUBP2: view

Function for NUBP2 Gene

Molecular function for NUBP2 Gene

GENATLAS Biochemistry:
nucleotide-binding protein 2,ubiquitously expressed,predominantly in a adult skeletal muscle,homolog to the mrp gene of E.coli,MinD like
UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.

Gene Ontology (GO) - Molecular Function for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 10486206
GO:0005515 protein binding IPI 18573874
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with NUBP2: view
genes like me logo Genes that share phenotypes with NUBP2: view

Animal Model Products

CRISPR Products

miRNA for NUBP2 Gene

miRTarBase miRNAs that target NUBP2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUBP2 Gene

Localization for NUBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUBP2 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Enriched at the centrosomes during mitosis. Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis (By similarity). Localized at centrioles and in the nucleus at interphase (By similarity). Colocalizes with nubp-1 at prometaphase (By similarity). {ECO:0000250 UniProtKB:Q9R061, ECO:0000255 HAMAP-Rule:MF_03039}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NUBP2 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
mitochondrion 2
cytosol 2
plasma membrane 1
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005814 centriole IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NUBP2: view

Pathways & Interactions for NUBP2 Gene

genes like me logo Genes that share pathways with NUBP2: view

Pathways by source for NUBP2 Gene

2 Reactome pathways for NUBP2 Gene

Gene Ontology (GO) - Biological Process for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016226 iron-sulfur cluster assembly IEA --
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with NUBP2: view

No data available for SIGNOR curated interactions for NUBP2 Gene

Drugs & Compounds for NUBP2 Gene

No Compound Related Data Available

Transcripts for NUBP2 Gene

Unigene Clusters for NUBP2 Gene

Nucleotide binding protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUBP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - - - -
SP14: - - - - - - -
SP15: - - - - - -

ExUns: 10a · 10b · 10c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for NUBP2 Gene

GeneLoc Exon Structure for
NUBP2
ECgene alternative splicing isoforms for
NUBP2

Expression for NUBP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NUBP2 Gene

Protein differential expression in normal tissues from HIPED for NUBP2 Gene

This gene is overexpressed in Bone (24.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NUBP2 Gene



Protein tissue co-expression partners for NUBP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NUBP2 Gene:

NUBP2

SOURCE GeneReport for Unigene cluster for NUBP2 Gene:

Hs.256549

mRNA Expression by UniProt/SwissProt for NUBP2 Gene:

Q9Y5Y2-NUBP2_HUMAN
Tissue specificity: Widely expressed with highest expression in skeletal muscle.

Evidence on tissue expression from TISSUES for NUBP2 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with NUBP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NUBP2 Gene

Orthologs for NUBP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUBP2 34 35
  • 99.02 (n)
cow
(Bos Taurus)
Mammalia NUBP2 34 35
  • 87.53 (n)
dog
(Canis familiaris)
Mammalia NUBP2 34 35
  • 84.81 (n)
rat
(Rattus norvegicus)
Mammalia Nubp2 34
  • 82.21 (n)
mouse
(Mus musculus)
Mammalia Nubp2 34 16 35
  • 81.72 (n)
oppossum
(Monodelphis domestica)
Mammalia NUBP2 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUBP2 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUBP2 34 35
  • 77.82 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia nubp2 34
  • 71.16 (n)
Str.3565 34
zebrafish
(Danio rerio)
Actinopterygii nubp2 34 35
  • 67.82 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta NUBP2_ANOGA 34
  • 61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4858 36 34 35
  • 57.18 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL006W 34
  • 57.41 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFD1 35 37 34
  • 52.46 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13970g 34
  • 50.7 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01084 34
  • 59.36 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC806.02c 34
  • 53.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToOne
Species where no ortholog for NUBP2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUBP2 Gene

ENSEMBL:
Gene Tree for NUBP2 (if available)
TreeFam:
Gene Tree for NUBP2 (if available)

Paralogs for NUBP2 Gene

genes like me logo Genes that share paralogs with NUBP2: view

No data available for Paralogs for NUBP2 Gene

Variants for NUBP2 Gene

Sequence variations from dbSNP and Humsavar for NUBP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000588840 -- 1,789,289(+) TCCGT(C/T)GTCAA downstream-variant-500B
rs1000740118 -- 1,787,956(+) TGGGG(A/G)ACGTG nc-transcript-variant, reference, missense
rs1001138988 -- 1,784,052(+) CAGGA(C/T)GGATT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001367563 -- 1,787,796(+) CCTAC(C/T)AGCCC nc-transcript-variant, reference, stop-gained
rs1001400199 -- 1,787,990(+) AAGAC(-/G)GGGCT nc-transcript-variant, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for NUBP2 Gene

Variant ID Type Subtype PubMed ID
dgv4856n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1042986 CNV loss 25217958
nsv1051692 CNV loss 25217958
nsv1160328 CNV deletion 26073780
nsv457335 CNV loss 19166990
nsv457336 CNV loss 19166990
nsv471069 CNV loss 18288195
nsv517196 CNV gain+loss 19592680
nsv518641 CNV loss 19592680
nsv571169 CNV loss 21841781
nsv571170 CNV loss 21841781
nsv571171 CNV gain+loss 21841781
nsv571172 CNV loss 21841781
nsv827500 CNV gain 20364138
nsv952900 CNV deletion 24416366

Variation tolerance for NUBP2 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUBP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NUBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUBP2 Gene

Disorders for NUBP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NUBP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
autonomic nervous system neoplasm
  • tumor of autonomic nervous system
peripheral nervous system neoplasm
  • neoplasm of peripheral nerve
- elite association - COSMIC cancer census association via MalaCards
Search NUBP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NUBP2

Genetic Association Database (GAD)
NUBP2
Human Genome Epidemiology (HuGE) Navigator
NUBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUBP2
genes like me logo Genes that share disorders with NUBP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NUBP2 Gene

Publications for NUBP2 Gene

  1. Two novel mouse genes -- Nubp2, mapped to the T-complex on chromosome 17, and Nubp1, mapped to chromosome 16 -- establish a new gene family of nucleotide-binding proteins in eukaryotes. (PMID: 10486206) Nakashima H. … Ko M.S.H. (Genomics 1999) 2 3 4 22 64
  2. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PMID: 21216879) Kaplan R.C. … Wallaschofski H. (Hum. Mol. Genet. 2011) 3 46 64
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  4. Comparison of intracellular localization of Nubp1 and Nubp2 using GFP fusion proteins. (PMID: 19263241) Okuno T. … Kogure K. (Mol. Biol. Rep. 2010) 3 22 64
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 46 64

Products for NUBP2 Gene

Sources for NUBP2 Gene

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