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Aliases for NUBP2 Gene

Aliases for NUBP2 Gene

  • Nucleotide Binding Protein 2 2 3 5
  • Nucleotide Binding Protein 2 (MinD Homolog, E. Coli) 2 3
  • NBP 2 3 4
  • Homolog Of Yeast Cytosolic Fe-S Cluster Deficient 1 3
  • Nucleotide Binding Protein 2 (E.Coli MinD Like) 2
  • Nucleotide-Binding Protein 2 4
  • NUBP1 3
  • CFD1 3

External Ids for NUBP2 Gene

Previous GeneCards Identifiers for NUBP2 Gene

  • GC16P001850
  • GC16P001772
  • GC16P001832

Summaries for NUBP2 Gene

Entrez Gene Summary for NUBP2 Gene

  • This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

GeneCards Summary for NUBP2 Gene

NUBP2 (Nucleotide Binding Protein 2) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. GO annotations related to this gene include nucleotide binding and 4 iron, 4 sulfur cluster binding.

UniProtKB/Swiss-Prot for NUBP2 Gene

  • Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.

Gene Wiki entry for NUBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUBP2 Gene

Genomics for NUBP2 Gene

Regulatory Elements for NUBP2 Gene

Promoters for NUBP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUBP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUBP2 Gene

Chromosome:
16
Start:
1,782,901 bp from pter
End:
1,789,191 bp from pter
Size:
6,291 bases
Orientation:
Plus strand

Genomic View for NUBP2 Gene

Genes around NUBP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUBP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUBP2 Gene

Proteins for NUBP2 Gene

  • Protein details for NUBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y2-NUBP2_HUMAN
    Recommended name:
    Cytosolic Fe-S cluster assembly factor NUBP2
    Protein Accession:
    Q9Y5Y2
    Secondary Accessions:
    • D3DU80
    • Q9NWB2

    Protein attributes for NUBP2 Gene

    Size:
    271 amino acids
    Molecular mass:
    28825 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Heterotetramer of 2 NUBP1 and 2 NUBP2 chains (By similarity). Interacts with KIFC1 (By similarity). Interacts with NUBP1 (PubMed:18573874).

neXtProt entry for NUBP2 Gene

Proteomics data for NUBP2 Gene at MOPED

Post-translational modifications for NUBP2 Gene

  • Ubiquitination at Lys 45 and Lys 98
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUBP2 Gene

Domains & Families for NUBP2 Gene

Gene Families for NUBP2 Gene

Protein Domains for NUBP2 Gene

Suggested Antigen Peptide Sequences for NUBP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y2

UniProtKB/Swiss-Prot:

NUBP2_HUMAN :
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Family:
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
genes like me logo Genes that share domains with NUBP2: view

Function for NUBP2 Gene

Molecular function for NUBP2 Gene

GENATLAS Biochemistry:
nucleotide-binding protein 2,ubiquitously expressed,predominantly in a adult skeletal muscle,homolog to the mrp gene of E.coli,MinD like
UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure.

Gene Ontology (GO) - Molecular Function for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 18573874
genes like me logo Genes that share ontologies with NUBP2: view
genes like me logo Genes that share phenotypes with NUBP2: view

Animal Model Products

miRNA for NUBP2 Gene

miRTarBase miRNAs that target NUBP2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NUBP2 Gene

Localization for NUBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUBP2 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center. Note=Enriched at the centrosomes during mitosis. Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis (By similarity). Localized at centrioles and in the nucleus at interphase (By similarity). Colocalizes with nubp-1 at prometaphase (By similarity). {ECO:0000250 UniProtKB:Q9R061, ECO:0000255 HAMAP-Rule:MF_03039}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUBP2 Gene COMPARTMENTS Subcellular localization image for NUBP2 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 2
mitochondrion 2
extracellular 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IEA --
GO:0031616 spindle pole centrosome IEA --
genes like me logo Genes that share ontologies with NUBP2: view

Pathways & Interactions for NUBP2 Gene

genes like me logo Genes that share pathways with NUBP2: view

Pathways by source for NUBP2 Gene

2 Reactome pathways for NUBP2 Gene

Gene Ontology (GO) - Biological Process for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NUBP2: view

No data available for SIGNOR curated interactions for NUBP2 Gene

Drugs & Compounds for NUBP2 Gene

No Compound Related Data Available

Transcripts for NUBP2 Gene

Unigene Clusters for NUBP2 Gene

Nucleotide binding protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUBP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - - - -
SP14: - - - - - - -
SP15: - - - - - -

ExUns: 10a · 10b · 10c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for NUBP2 Gene

GeneLoc Exon Structure for
NUBP2
ECgene alternative splicing isoforms for
NUBP2

Expression for NUBP2 Gene

mRNA expression in normal human tissues for NUBP2 Gene

Protein differential expression in normal tissues from HIPED for NUBP2 Gene

This gene is overexpressed in Bone (24.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUBP2 Gene



SOURCE GeneReport for Unigene cluster for NUBP2 Gene Hs.256549

mRNA Expression by UniProt/SwissProt for NUBP2 Gene

Q9Y5Y2-NUBP2_HUMAN
Tissue specificity: Widely expressed with highest expression in skeletal muscle.
genes like me logo Genes that share expression patterns with NUBP2: view

Protein tissue co-expression partners for NUBP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NUBP2 Gene

Orthologs for NUBP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUBP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUBP2 35
  • 87.53 (n)
  • 87.04 (a)
NUBP2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUBP2 35
  • 84.81 (n)
  • 85.56 (a)
NUBP2 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nubp2 35
  • 81.72 (n)
  • 85.07 (a)
Nubp2 16
Nubp2 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUBP2 35
  • 99.02 (n)
  • 99.26 (a)
NUBP2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nubp2 35
  • 82.21 (n)
  • 86.57 (a)
oppossum
(Monodelphis domestica)
Mammalia NUBP2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUBP2 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUBP2 35
  • 77.82 (n)
  • 81.37 (a)
NUBP2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nubp2 35
  • 71.16 (n)
  • 76.52 (a)
Str.3565 35
zebrafish
(Danio rerio)
Actinopterygii nubp2 35
  • 67.82 (n)
  • 69.35 (a)
nubp2 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4858 37
  • 55 (a)
CG4858 35
  • 57.18 (n)
  • 54.94 (a)
CG4858 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NUBP2_ANOGA 35
  • 61 (n)
  • 55.73 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL006W 35
  • 57.41 (n)
  • 54.75 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13970g 35
  • 50.7 (n)
  • 52.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFD1 35
  • 52.46 (n)
  • 54.85 (a)
CFD1 36
  • 45 (a)
OneToOne
CFD1 38
bread mold
(Neurospora crassa)
Ascomycetes NCU01084 35
  • 59.36 (n)
  • 57.77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC806.02c 35
  • 53.33 (n)
  • 57.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for NUBP2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUBP2 Gene

ENSEMBL:
Gene Tree for NUBP2 (if available)
TreeFam:
Gene Tree for NUBP2 (if available)

Paralogs for NUBP2 Gene

genes like me logo Genes that share paralogs with NUBP2: view

No data available for Paralogs for NUBP2 Gene

Variants for NUBP2 Gene

Sequence variations from dbSNP and Humsavar for NUBP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs35030308 - 1,788,646(-) GGCGG(A/G)GCTCC nc-transcript-variant, reference, missense
rs34028164 - 1,788,695(+) CGCGA(C/T)GCCCG nc-transcript-variant, reference, synonymous-codon, missense
rs57822546 - 1,788,049(+) ACTGC(A/G/T)CGGTG nc-transcript-variant, reference, missense
rs182939 -- 1,789,376(+) ACAGC(C/T)GGCCC downstream-variant-500B
rs344357 -- 1,786,254(+) CCCTT(C/G)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUBP2 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904954 CNV Loss 21882294
nsv905017 CNV Loss 21882294
nsv518641 CNV Loss 19592680
nsv457335 CNV Loss 19166990
dgv2538n71 CNV Loss 21882294
nsv517196 CNV Gain+Loss 19592680
nsv905023 CNV Gain 21882294
dgv2539n71 CNV Loss 21882294
dgv2540n71 CNV Loss 21882294
nsv457336 CNV Loss 19166990
nsv471069 CNV Loss 18288195
dgv2541n71 CNV Loss 21882294
nsv905031 CNV Gain+Loss 21882294
dgv2542n71 CNV Loss 21882294
nsv905034 CNV Loss 21882294
nsv827500 CNV Gain 20364138
dgv2543n71 CNV Loss 21882294
nsv905042 CNV Loss 21882294

Variation tolerance for NUBP2 Gene

Residual Variation Intolerance Score: 91.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.37; 42.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUBP2 Gene

HapMap Linkage Disequilibrium report
NUBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUBP2 Gene

Disorders for NUBP2 Gene

Relevant External Links for NUBP2

Genetic Association Database (GAD)
NUBP2
Human Genome Epidemiology (HuGE) Navigator
NUBP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUBP2

No disorders were found for NUBP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUBP2 Gene

Publications for NUBP2 Gene

  1. Two novel mouse genes -- Nubp2, mapped to the T-complex on chromosome 17, and Nubp1, mapped to chromosome 16 -- establish a new gene family of nucleotide-binding proteins in eukaryotes. (PMID: 10486206) Nakashima H. … Ko M.S.H. (Genomics 1999) 2 3 4 23 67
  2. Comparison of intracellular localization of Nubp1 and Nubp2 using GFP fusion proteins. (PMID: 19263241) Okuno T. … Kogure K. (Mol. Biol. Rep. 2010) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. (PMID: 24797263) Tong J. … Moran M.F. (Mol. Cell Proteomics 2014) 3

Products for NUBP2 Gene

Sources for NUBP2 Gene

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