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Aliases for NUBP2 Gene

Aliases for NUBP2 Gene

  • Nucleotide Binding Protein 2 2 3
  • Nucleotide Binding Protein 2 (MinD Homolog, E. Coli) 2 3
  • NBP 2 3 4
  • CFD1 3 6
  • C447E6.1 (Nucleotide Binding Protein 1 (E.Coli MinD Like) ) 3
  • Homolog Of Yeast Cytosolic Fe-S Cluster Deficient 1 3
  • Nucleotide Binding Protein 2 (E.Coli MinD Like) 2
  • Cytosolic Fe-S Cluster Assembly Factor NUBP2 3
  • Nucleotide-Binding Protein 2 4
  • NUBP1 3

External Ids for NUBP2 Gene

Previous GeneCards Identifiers for NUBP2 Gene

  • GC16P001850
  • GC16P001772
  • GC16P001832

Summaries for NUBP2 Gene

Entrez Gene Summary for NUBP2 Gene

  • This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]

GeneCards Summary for NUBP2 Gene

NUBP2 (Nucleotide Binding Protein 2) is a Protein Coding gene. Diseases associated with NUBP2 include lung cancer. Among its related pathways are Metabolism and Cytosolic Iron-sulfur Cluster Assembly. GO annotations related to this gene include nucleotide binding and 4 iron, 4 sulfur cluster binding.

UniProtKB/Swiss-Prot for NUBP2 Gene

  • Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.

Gene Wiki entry for NUBP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUBP2 Gene

Genomics for NUBP2 Gene

Regulatory Elements for NUBP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUBP2 Gene

Start:
1,782,901 bp from pter
End:
1,789,191 bp from pter
Size:
6,291 bases
Orientation:
Plus strand

Genomic View for NUBP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUBP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUBP2 Gene

Proteins for NUBP2 Gene

  • Protein details for NUBP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5Y2-NUBP2_HUMAN
    Recommended name:
    Cytosolic Fe-S cluster assembly factor NUBP2
    Protein Accession:
    Q9Y5Y2
    Secondary Accessions:
    • D3DU80
    • Q9NWB2

    Protein attributes for NUBP2 Gene

    Size:
    271 amino acids
    Molecular mass:
    28825 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.;
    Quaternary structure:
    • Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1 (By similarity). Interacts with NUBP1.

neXtProt entry for NUBP2 Gene

Proteomics data for NUBP2 Gene at MOPED

Post-translational modifications for NUBP2 Gene

  • Ubiquitination at Lys45 and Lys98
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NUBP2 Gene

Domains for NUBP2 Gene

Protein Domains for NUBP2 Gene

Suggested Antigen Peptide Sequences for NUBP2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5Y2

UniProtKB/Swiss-Prot:

NUBP2_HUMAN :
  • Q9Y5Y2
Family:
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
genes like me logo Genes that share domains with NUBP2: view

No data available for Gene Families for NUBP2 Gene

Function for NUBP2 Gene

Molecular function for NUBP2 Gene

GENATLAS Biochemistry: nucleotide-binding protein 2,ubiquitously expressed,predominantly in a adult skeletal muscle,homolog to the mrp gene of E.coli,MinD like
UniProtKB/Swiss-Prot Function: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.

Gene Ontology (GO) - Molecular Function for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 10486206
GO:0005515 protein binding IPI 18573874
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051539 4 iron, 4 sulfur cluster binding IEA --
genes like me logo Genes that share ontologies with NUBP2: view

Phenotypes for NUBP2 Gene

genes like me logo Genes that share phenotypes with NUBP2: view

Animal Model Products

CRISPR Products

miRNA for NUBP2 Gene

miRTarBase miRNAs that target NUBP2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUBP2 Gene

Localization for NUBP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUBP2 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Enriched at the centrosomes during mitosis. {ECO:0000255 HAMAP-Rule:MF_03039}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUBP2 Gene COMPARTMENTS Subcellular localization image for NUBP2 gene
Compartment Confidence
cytoskeleton 2
mitochondrion 2
nucleus 2
cytosol 1
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0031616 spindle pole centrosome IEA --
genes like me logo Genes that share ontologies with NUBP2: view

Pathways for NUBP2 Gene

genes like me logo Genes that share pathways with NUBP2: view

Pathways by source for NUBP2 Gene

2 Reactome pathways for NUBP2 Gene

Gene Ontology (GO) - Biological Process for NUBP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016226 iron-sulfur cluster assembly IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NUBP2: view

Transcripts for NUBP2 Gene

Unigene Clusters for NUBP2 Gene

Nucleotide binding protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NUBP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NUBP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10: - - - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - - - -
SP14: - - - - - - -
SP15: - - - - - -

ExUns: 10a · 10b · 10c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for NUBP2 Gene

GeneLoc Exon Structure for
NUBP2
ECgene alternative splicing isoforms for
NUBP2

Expression for NUBP2 Gene

mRNA expression in normal human tissues for NUBP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUBP2 Gene

SOURCE GeneReport for Unigene cluster for NUBP2 Gene Hs.256549

mRNA Expression by UniProt/SwissProt for NUBP2 Gene

Q9Y5Y2-NUBP2_HUMAN
Tissue specificity: Widely expressed with highest expression in skeletal muscle
genes like me logo Genes that share expressions with NUBP2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NUBP2 Gene

Orthologs for NUBP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NUBP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUBP2 35
  • 99.02 (n)
  • 99.26 (a)
NUBP2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUBP2 35
  • 87.53 (n)
  • 87.04 (a)
NUBP2 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUBP2 35
  • 84.81 (n)
  • 85.56 (a)
NUBP2 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nubp2 35
  • 81.72 (n)
  • 85.07 (a)
Nubp2 16
Nubp2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUBP2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUBP2 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nubp2 35
  • 82.21 (n)
  • 86.57 (a)
chicken
(Gallus gallus)
Aves NUBP2 35
  • 77.82 (n)
  • 81.37 (a)
NUBP2 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nubp2 35
  • 71.16 (n)
  • 76.52 (a)
Str.3565 35
zebrafish
(Danio rerio)
Actinopterygii nubp2 35
  • 67.82 (n)
  • 69.35 (a)
nubp2 36
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NUBP2_ANOGA 35
  • 61 (n)
  • 55.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4858 35
  • 57.18 (n)
  • 54.94 (a)
CG4858 36
  • 53 (a)
OneToOne
CG4858 37
  • 55 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL006W 35
  • 57.41 (n)
  • 54.75 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFD1 35
  • 52.46 (n)
  • 54.85 (a)
CFD1 36
  • 45 (a)
OneToOne
CFD1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D13970g 35
  • 50.7 (n)
  • 52.09 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01084 35
  • 59.36 (n)
  • 57.77 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC806.02c 35
  • 53.33 (n)
  • 57.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for NUBP2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUBP2 Gene

ENSEMBL:
Gene Tree for NUBP2 (if available)
TreeFam:
Gene Tree for NUBP2 (if available)

Paralogs for NUBP2 Gene

Selected SIMAP similar genes for NUBP2 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with NUBP2: view

No data available for Paralogs for NUBP2 Gene

Variants for NUBP2 Gene

Sequence variations from dbSNP and Humsavar for NUBP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs182939 -- 1,789,376(+) ACAGC(C/T)GGCCC downstream-variant-500B
rs344357 -- 1,786,254(+) CCCTT(C/G)CACAC intron-variant
rs344358 -- 1,787,899(+) CCTGC(C/T)GGTGC intron-variant
rs344359 -- 1,788,639(+) TTCCC(C/T)GGGAG synonymous-codon, reference, missense, nc-transcript-variant
rs344360 -- 1,789,220(+) CGGGG(C/T)CAGAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NUBP2 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904954 CNV Loss 21882294
nsv905017 CNV Loss 21882294
nsv518641 CNV Loss 19592680
nsv457335 CNV Loss 19166990
dgv2538n71 CNV Loss 21882294
nsv517196 CNV Gain+Loss 19592680
nsv905023 CNV Gain 21882294
dgv2539n71 CNV Loss 21882294
dgv2540n71 CNV Loss 21882294
nsv457336 CNV Loss 19166990
nsv471069 CNV Loss 18288195
dgv2541n71 CNV Loss 21882294
nsv905031 CNV Gain+Loss 21882294
dgv2542n71 CNV Loss 21882294
nsv905034 CNV Loss 21882294
nsv827500 CNV Gain 20364138
dgv2543n71 CNV Loss 21882294
nsv905042 CNV Loss 21882294

Relevant External Links for NUBP2 Gene

HapMap Linkage Disequilibrium report
NUBP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUBP2 Gene

Disorders for NUBP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NUBP2 Gene including...

Search for NUBP2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for NUBP2 Gene

Relevant External Links for NUBP2

Genetic Association Database (GAD)
NUBP2
Human Genome Epidemiology (HuGE) Navigator
NUBP2
genes like me logo Genes that share disorders with NUBP2: view

No data available for UniProtKB/Swiss-Prot for NUBP2 Gene

Publications for NUBP2 Gene

  1. Two novel mouse genes -- Nubp2, mapped to the T-complex on chromosome 17, and Nubp1, mapped to chromosome 16 -- establish a new gene family of nucleotide-binding proteins in eukaryotes. (PMID: 10486206) Nakashima H. … Ko M.S.H. (Genomics 1999) 2 3 4 23
  2. Comparison of intracellular localization of Nubp1 and Nubp2 using GFP fusion proteins. (PMID: 19263241) Okuno T. … Kogure K. (Mol. Biol. Rep. 2010) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis. (PMID: 18573874) Stehling O. … Lill R. (Mol. Cell. Biol. 2008) 3 4

Products for NUBP2 Gene

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