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NUBP2 Gene

protein-coding   GIFtS: 60
GCID: GC16P001832

Nucleotide Binding Protein 2

(Previous names: nucleotide binding protein 2 (E.coli MinD like), nucleotide...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Nucleotide Binding Protein 21 2     NUBP12
Nucleotide Binding Protein 2 (MinD Homolog, E. Coli)1 2     C447E6.1 (Nucleotide Binding Protein 1 (E.Coli MinD Like) )2
NBP 22 3     Cytosolic Fe-S Cluster Assembly Factor NUBP22
CFD12 5     Homolog Of Yeast Cytosolic Fe-S Cluster Deficient 12
Nucleotide Binding Protein 2 (E.Coli MinD Like)1     Nucleotide-Binding Protein 23

External Ids:    HGNC: 80421   Entrez Gene: 101012   Ensembl: ENSG000000959067   OMIM: 6107795   UniProtKB: Q9Y5Y23   

Export aliases for NUBP2 gene to outside databases

Previous GC identifers: GC16P001850 GC16P001772


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUBP2 Gene:
This gene encodes an adenosine triphosphate (ATP) and metal-binding protein that is required for the assembly of
cyotosolic iron-sulfur proteins. The encoded protein functions in a heterotetramer with nucleotide-binding
protein 1 (NUBP1). Alternative splicing results in multiple transcript variants. (provided by RefSeq, Oct 2013)

GeneCards Summary for NUBP2 Gene:
NUBP2 (nucleotide binding protein 2) is a protein-coding gene. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and nucleotide binding.

UniProtKB/Swiss-Prot: NUBP2_HUMAN, Q9Y5Y2
Function: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation
of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the
de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity)

Gene Wiki entry for NUBP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUBP2 gene promoter:
         USF1   Tal-1   Pax-5   Olf-1   YY1   E47   Roaz   CP2   USF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUBP2 promoter sequence
   Search Chromatin IP Primers for NUBP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUBP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

NUBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUBP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P001832:  view genomic region     (about GC identifiers)

Start:
1,832,902 bp from pter      End:
1,839,192 bp from pter
Size:
6,291 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUBP2_HUMAN, Q9Y5Y2 (See protein sequence)
Recommended Name: Cytosolic Fe-S cluster assembly factor NUBP2  
Size: 271 amino acids; 28825 Da
Cofactor: Binds 4 4Fe-4S clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and
two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer (By similarity)
Subunit: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1 (By similarity). Interacts with NUBP1
Developmental stage: Expressed in fetal brain, lung, liver and kidney
Secondary accessions: D3DU80 Q9NWB2

Explore the universe of human proteins at neXtProt for NUBP2: NX_Q9Y5Y2

Explore proteomics data for NUBP2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys45, Lys98
  • Modification sites at PhosphoSitePlus

  • See NUBP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001271430.1  NP_001271431.1  NP_036357.1  

    ENSEMBL proteins: 
     ENSP00000262302   ENSP00000456928   ENSP00000454576   ENSP00000455896   ENSP00000454982  
     ENSP00000456284   ENSP00000454815   ENSP00000455739   ENSP00000456199   ENSP00000460079  
     ENSP00000437763  
    Reactome Protein details: Q9Y5Y2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028600 NUBP2/Cfd1_eukaryotes
     IPR019591 ATPase-like_ParA/MinD
     IPR000808 Mrp_CS
     IPR027417 P-loop_NTPase
     IPR025669 AAA_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y5Y2

    ProtoNet protein and cluster: Q9Y5Y2

    1 Blocks protein domain: IPB000808 Mrp family

    UniProtKB/Swiss-Prot: NUBP2_HUMAN, Q9Y5Y2
    Similarity: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily


    Find genes that share domains with NUBP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUBP2_HUMAN, Q9Y5Y2
    Function: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation
    of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the
    de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity)

         Genatlas biochemistry entry for NUBP2:
    nucleotide-binding protein 2,ubiquitously expressed,predominantly in a adult skeletal muscle,homolog to the mrp
    gene of E.coli,MinD like

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS10486206
    GO:0005515protein binding IPI18573874
    GO:0005524ATP binding IEA--
    GO:0046872metal ion binding IEA--
    GO:00515394 iron, 4 sulfur cluster binding IEA--
         
    Find genes that share ontologies with NUBP2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for NUBP2:
     Decreased Wnt reporter activit  Increased gamma-H2AX phosphory 

    Animal Models:
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    hsa-let-7b-5p (MIRT032194), hsa-mir-26b-5p (MIRT028953)

    Block miRNA regulation of human, mouse, rat NUBP2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NUBP2:
    hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidNUBP2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUBP2_HUMAN, Q9Y5Y2: Nucleus (By similarity). Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    (By similarity). Note=Enriched at the centrosomes during mitosis (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    mitochondrion2
    nucleus2
    cytosol1
    extracellular1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center ----
    GO:0031616spindle pole centrosome IEA--

    Find genes that share ontologies with NUBP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUBP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    2Cytosolic Iron-sulfur Cluster Assembly
    Cytosolic Iron-sulfur Cluster Assembly


    Find genes that share SuperPaths with NUBP2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NUBP2
        Cytosolic iron-sulfur cluster assembly


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUBP2
    Interactions:

        Search GeneGlobe Interaction Network for NUBP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NUBP2 (Q9Y5Y23 ENSP000002623024) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIAO1O760713, ENSP000004182874I2D: score=1 STRING: ENSP00000418287
    PHLDA3Q9Y5J53, ENSP000003562784I2D: score=1 STRING: ENSP00000356278
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    NARFLQ9H6Q43, ENSP000002515884I2D: score=1 STRING: ENSP00000251588
    NUBP1P533843I2D: score=7 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016226iron-sulfur cluster assembly IEA--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with NUBP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for NUBP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUBP2 gene (3 alternative transcripts): 
    NM_001284501.1  NM_001284502.1  NM_012225.3  

    Unigene Cluster for NUBP2:

    Nucleotide binding protein 2
    Hs.256549  [show with all ESTs]
    Unigene Representative Sequence: AK124460
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262302(uc002cmw.4 uc002cmx.4) ENST00000566447 ENST00000568834
    ENST00000567700 ENST00000566090 ENST00000563136 ENST00000565987 ENST00000568287
    ENST00000565603 ENST00000569898 ENST00000565134 ENST00000564227 ENST00000562263
    ENST00000568706 ENST00000568610 ENST00000563821 ENST00000543305
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    1 qRT-PCR Assays for microRNA that regulate NUBP2:
    hsa-miR-544b
    SwitchGear 3'UTR luciferase reporter plasmidNUBP2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NUBP2
      QuantiFast Probe-based Assays in human, mouse, rat NUBP2

    Additional mRNA sequence: 

    AF118394.1 AK001023.1 AK093593.1 AK124460.1 AK300696.1 AK315611.1 BC002768.2 BC008005.1 
    BX648907.1 Z36821.1 

    19 DOTS entries:

    DT.448601  DT.101965058  DT.95243848  DT.100721594  DT.92440514  DT.97847650  DT.120716714  DT.120716768 
    DT.120716861  DT.92440513  DT.95243840  DT.120716867  DT.100813710  DT.92440515  DT.95243854  DT.100813713 
    DT.100813716  DT.120716734  DT.95258934 

    Selected AceView cDNA sequences (see all 299):

    AA349876 BU688268 BM913997 BF972798 CR590570 R53313 BF439443 BQ949274 
    CA495403 CR618786 BU845069 N99453 BE266149 BU845241 CF456724 BE741159 
    CR616284 CR597386 CR619719 BI908727 BM921386 BM984790 AI811247 BG491104 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUBP2 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^
    SP1:                                            -     -     -     -     -     -           -                 -     -                                             
    SP2:                                            -     -     -     -     -     -           -                 -     -                             -               
    SP3:                                            -     -     -     -     -     -           -     -     -     -     -                                             
    SP4:                                                                    -     -           -     -     -     -     -                                             
    SP5:                                            -     -     -     -     -     -                                                                                 

    ExUns: 10a · 10b · 10c
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for NUBP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUBP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTTGTAACT
    NUBP2 Expression
    About this image

    NUBP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUBP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.256549

    UniProtKB/Swiss-Prot: NUBP2_HUMAN, Q9Y5Y2
    Tissue specificity: Widely expressed with highest expression in skeletal muscle

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NUBP2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nubp21 , 5 nucleotide binding protein 21, 5 81.72(n)1
    85.07(a)1
      17 (12.53 cM)5
    264261  NM_011956.31  NP_036086.11 
     248826115 
    chicken
    (Gallus gallus)
    Aves NUBP21 nucleotide binding protein 2 77.82(n)
    81.37(a)
      416402  NM_001007833.2  NP_001007834.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BX845930.12   -- 71.72(n)    BX845930.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BM890137.12   -- 76.42(n)    BM890137.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG48581 , 3 nucleotide binding3
    CG48581
    55(a)3
    57.18(n)1
    54.94(a)1
      77C73
    402821  NM_140986.31  NP_649243.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CFD1(YIL003W)4
    CFD11
    Highly conserved, iron-sulfur cluster binding protein more4
    CFD11
    52.46(n)1
    54.85(a)1
      9(349122-350003)4
    8548141, 4  NP_012263.11, 4 


    ENSEMBL Gene Tree for NUBP2 (if available)
    TreeFam Gene Tree for NUBP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUBP2 gene
    2 SIMAP similar genes for NUBP2 using alignment to 10 protein entries:     NUBP2_HUMAN (see all proteins):
    NUBP1    NUBPL

    Find genes that share paralogs with NUBP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUBP2 (see all 246)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs121497771,2
    C,F,H--1834724(+) TAAACA/GGGGAA 1 -- int122Minor allele frequency- G:0.49NS EA NA WA CSA 2342
    rs2008976221,2
    --1834874(+) CTACG-/AAAAAA 1 -- int10--------
    rs24734651,2
    C--1834882(+) AAAAAA/TAAAAA 1 -- int16Minor allele frequency- T:0.00NA WA 12
    rs1996055531,2
    C--1834882(+) AAAAA-/TAAAAA 1 -- int10--------
    rs1413162891,2
    --1835010(+) ATTGCA/GCCACT 1 -- int10--------
    rs1450435301,2
    --1835159(+) AGAGCG/TCACTC 1 -- int10--------
    rs1509962551,2
    --1835226(+) CCACCC/GGGCAG 1 -- int10--------
    rs27451701,2
    C,F,H--1835231(+) CGGCAG/TGCTCA 1 -- int122Minor allele frequency- T:0.50NS EA NA WA CSA 2346
    rs25753521,2
    C,F,H--1835393(-) GGGAAC/TGGTGC 1 -- int124Minor allele frequency- T:0.17NS EA NA WA CSA 2342
    rs1897893131,2
    C--1835409(+) TCTGCC/TAACGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for NUBP2 (1832902 - 1839192 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NUBP2 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv904954CNV Loss21882294
    dgv2541n71CNV Loss21882294
    nsv457336CNV Loss19166990
    dgv2540n71CNV Loss21882294
    nsv905017CNV Loss21882294
    dgv2539n71CNV Loss21882294
    nsv905034CNV Loss21882294
    nsv518641CNV Loss19592680
    dgv2542n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUBP2
    DNA2.0 Custom Variant and Variant Library Synthesis for NUBP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610779    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NUBP2:
    Syndactyly

    Find genes that share disorders with NUBP2           About GenesLikeMe

    Genetic Association Database (GAD): NUBP2
    Human Genome Epidemiology (HuGE) Navigator: NUBP2 (4 documents)

    Export disorders for NUBP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUBP2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with NUBP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two novel mouse genes -- Nubp2, mapped to the T-complex on chromosome 17, and Nubp1, mapped to chromosome 16 -- establish a new gene family of nucleotide-binding proteins in eukaryotes. (PubMed id 10486206)1, 2, 3, 9 Nakashima H.... Ko M.S.H. (Genomics 1999)
    2. A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3. (PubMed id 21216879)1, 4 Kaplan R.C....Wallaschofski H. (Hum. Mol. Genet. 2011)
    3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    6. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    7. Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis. (PubMed id 18573874)1, 2 Stehling O.... Lill R. (Mol. Cell. Biol. 2008)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Comparison of intracellular localization of Nubp1 and Nubp2 using GFP fusion proteins. (PubMed id 19263241)1, 9 Okuno T....Kogure K. (Mol. Biol. Rep. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10101 HGNC: 8042 AceView: NUBP2 Ensembl:ENSG00000095906 euGenes: HUgn10101
    ECgene: NUBP2 H-InvDB: NUBP2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUBP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUBP2 gene:
    Search GeneIP for patents involving NUBP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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