Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NUBP1 Gene

protein-coding   GIFtS: 63
GCID: GC16P010837

Nucleotide Binding Protein 1

(Previous names: nucleotide binding protein 1 (E.coli MinD like), nucleotide...)
(Previous symbol: NBP1)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Nucleotide Binding Protein 11 2     Nucleotide-Binding Protein 12 3
NBP11 2 3     NBP 12 3
NBP2 3 5     NBP352
Nucleotide Binding Protein 1 (E.Coli MinD Like)1 2     Cytosolic Fe-S Cluster Assembly Factor NUBP12
Nucleotide Binding Protein 1 (MinD Homolog, E. Coli)1 2     Nucleotide Binding Protein (E.Coli MinD Like)2

External Ids:    HGNC: 80411   Entrez Gene: 46822   Ensembl: ENSG000001032747   OMIM: 6002805   UniProtKB: P533843   

Export aliases for NUBP1 gene to outside databases

Previous GC identifers: GC16P010631 GC16P010988 GC16P010804 GC16P010745 GC16P010756


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NUBP1 Gene:
NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 (PubMed
10486206)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NUBP1 Gene:
NUBP1 (nucleotide binding protein 1) is a protein-coding gene. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and nucleotide binding. An important paralog of this gene is NUBPL.

UniProtKB/Swiss-Prot: NUBP1_HUMAN, P53384
Function: Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic
iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins.
The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster
and its transfer to target apoproteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUBP1 gene promoter:
         Egr-3   STAT1   C/EBPbeta   AML1a   STAT1beta   STAT5A   STAT1alpha   GATA-1   Egr-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUBP1 promoter sequence
   Search Chromatin IP Primers for NUBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.13   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13.13

NUBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUBP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P010837:  view genomic region     (about GC identifiers)

Start:
10,837,643 bp from pter      End:
10,863,208 bp from pter
Size:
25,566 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NUBP1_HUMAN, P53384 (See protein sequence)
Recommended Name: Cytosolic Fe-S cluster assembly factor NUBP1  
Size: 320 amino acids; 34534 Da
Cofactor: Binds 4 4Fe-4S clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and
two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer (By similarity)
Subunit: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1 (By similarity). Interacts with NUBP2
Secondary accessions: Q32M30 Q498A9 Q53FS7
Alternative splicing: 2 isoforms:  P53384-1   P53384-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUBP1: NX_P53384

Explore proteomics data for NUBP1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NUBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265435.1  NP_002475.2  

    ENSEMBL proteins: 
     ENSP00000461746   ENSP00000283027   ENSP00000409654   ENSP00000460288   ENSP00000461723  
    Reactome Protein details: P53384

    NUBP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NUBP1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NUBP1
    GenScript Custom Purified and Recombinant Proteins Services for NUBP1
    Novus Biologicals NUBP1 Proteins
    Novus Biologicals NUBP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUBP1

     
    Search eBioscience for Proteins for NUBP1 

     
    antibodies-online proteins for NUBP1 (8 products) 

     
    antibodies-online peptides for NUBP1

    NUBP1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NUBP1
    Novus Biologicals NUBP1 Antibodies
    Abcam antibodies for NUBP1
    Cloud-Clone Corp. Antibodies for NUBP1
    Search ThermoFisher Antibodies for NUBP1
    antibodies-online antibodies for NUBP1 (28 products) 

    NUBP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NUBP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NUBP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NUBP1
    Cloud-Clone Corp. CLIAs for NUBP1
    Search eBioscience for ELISAs for NUBP1 
    antibodies-online kits for NUBP1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR025723 Anion-transp_ATPase-like_dom
     IPR019591 ATPase-like_ParA/MinD
     IPR000808 Mrp_CS
     IPR028601 NUBP1/Nbp35
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P53384

    ProtoNet protein and cluster: P53384

    1 Blocks protein domain: IPB000808 Mrp family

    UniProtKB/Swiss-Prot: NUBP1_HUMAN, P53384
    Similarity: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily


    Find genes that share domains with NUBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUBP1_HUMAN, P53384
    Function: Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic
    iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins.
    The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster
    and its transfer to target apoproteins

         Genatlas biochemistry entry for NUBP1:
    nucleotide binding protein 1,homolog to the mrp gene of E. coli,MinD-like

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS7926816
    GO:0005515protein binding IPI18573874
    GO:0005524ATP binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with NUBP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NUBP1:
     Decreased number of cells in m 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nubp1):
     limbs/digits/tail  mortality/aging  respiratory system  vision/eye 

    Find genes that share phenotypes with NUBP1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NUBP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NUBP1:
    hsa-mir-106b-5p (MIRT020454), hsa-mir-423-3p (MIRT042522), hsa-mir-93-5p (MIRT048800), hsa-mir-615-3p (MIRT039853)

    Block miRNA regulation of human, mouse, rat NUBP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NUBP1:
    hsa-miR-593
    SwitchGear 3'UTR luciferase reporter plasmidNUBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NUBP1
    Predesigned siRNA for gene silencing in human, mouse, rat NUBP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NUBP1

    Clone
    Products:
         
    OriGene clones in human, mouse for NUBP1 (see all 6)
    OriGene ORF clones in mouse, rat for NUBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUBP1 (NM_002484)
    Sino Biological Human cDNA Clone for NUBP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUBP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NUBP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NUBP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NUBP1_HUMAN, P53384: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane4
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA18573874
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with NUBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NUBP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.38
    2Cytosolic Iron-sulfur Cluster Assembly
    Cytosolic Iron-sulfur Cluster Assembly


    Find genes that share SuperPaths with NUBP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for NUBP1
        Cytosolic iron-sulfur cluster assembly


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUBP1
    Interactions:

        Search GeneGlobe Interaction Network for NUBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NUBP1 (P533842, 3 ENSP000002830274) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPRY2O435972, 3, ENSP000003663064MINT-8272039 I2D: score=2 STRING: ENSP00000366306
    NDNQ996083, ENSP000003326434I2D: score=2 STRING: ENSP00000332643
    NARFLQ9H6Q43, ENSP000002515884I2D: score=1 STRING: ENSP00000251588
    FRYLO949153, ENSP000003511134I2D: score=4 STRING: ENSP00000351113
    NUBP2Q9Y5Y23I2D: score=7 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006879cellular iron ion homeostasis IMP18573874
    GO:0010826negative regulation of centrosome duplication IEA--
    GO:0016049cell growth IMP18573874
    GO:0016226iron-sulfur cluster assembly IMP18573874
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with NUBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUBP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NUBP1 gene (2 alternative transcripts): 
    NM_001278506.1  NM_002484.3  

    Unigene Cluster for NUBP1:

    Nucleotide binding protein 1
    Hs.81469  [show with all ESTs]
    Unigene Representative Sequence: NM_002484
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574334 ENST00000571790 ENST00000574137(uc010bum.1) ENST00000283027(uc002daa.1 uc002dab.1)
    ENST00000433392 ENST00000571175 ENST00000574691 ENST00000573663
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NUBP1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NUBP1:
    hsa-miR-593
    SwitchGear 3'UTR luciferase reporter plasmidNUBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NUBP1
    Predesigned siRNA for gene silencing in human, mouse, rat NUBP1
    Clone
    Products:
         
    OriGene clones in human, mouse for NUBP1 (see all 6)
    OriGene ORF clones in mouse, rat for NUBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NUBP1 (NM_002484)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NUBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUBP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NUBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for NUBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUBP1
      QuantiTect SYBR Green Assays in human, mouse, rat NUBP1
      QuantiFast Probe-based Assays in human, mouse, rat NUBP1

    Additional mRNA sequence: 

    AK223204.1 AK307148.1 AK310089.1 BC100290.1 BC109322.1 BC109323.1 U01833.1 

    10 DOTS entries:

    DT.444422  DT.100785305  DT.92427553  DT.95084779  DT.75160830  DT.92427552  DT.120682833  DT.101979088 
    DT.91976080  DT.95084766 

    Selected AceView cDNA sequences (see all 135):

    BQ889231 AA369782 CB528598 AL552009 BQ009418 BX415664 BX094774 AL524488 
    CR601815 CR622882 CB529463 CD742985 AL551846 BQ063177 CR600910 BU507248 
    BM799495 BM423429 BM826703 CR613650 CD366483 AW404659 AI733196 AA937737 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUBP1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                                                                    -         
    SP2:                                                                              
    SP3:                                -                                             
    SP4:                          -                                                   
    SP5:                          -                                                   


    ECgene alternative splicing isoforms for NUBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NUBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCAGGACT
    NUBP1 Expression
    About this image


    NUBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    NUBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.81469
        Custom PCR Arrays for NUBP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NUBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for NUBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUBP1
    QuantiTect SYBR Green Assays in human, mouse, rat NUBP1
    QuantiFast Probe-based Assays in human, mouse, rat NUBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUBP1 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nubp11 , 5 nucleotide binding protein 11, 5 85.58(n)1
    89.34(a)1
      16 (5.61 cM)5
    264251  NM_011955.21  NP_036085.11 
     104119485 
    chicken
    (Gallus gallus)
    Aves NUBP11 nucleotide binding protein 1 74.42(n)
    79.94(a)
      416634  NM_001198641.1  NP_001185570.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUBP16
    nucleotide binding protein 1
    77(a)
    1 ↔ 1
    GL343592.1(308887-319617)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.160602 Xenopus laevis transcribed sequence with moderate similarity more 76.88(n)    CF547019.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.293992 Danio rerio cDNA clone IMAGE6794953, partial cds 78.58(n)    BC064668.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG179041 , 3 nucleotide binding3
    CG179041
    58(a)
    (best of 2)3
    60.93(n)1
    59.5(a)1
      36A123
    350001  NM_135961.41  NP_609805.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F10G8.61 , 3 nucleotide binding protein3
    F10G8.61
    50(a)3
    57.79(n)1
    55.59(a)1
      I(10054503-10055928)3
    1728681  NM_060252.41  NP_492653.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NBP35(YGL091C)4
    NBP351
    Essential iron-sulfur cluster binding protein localized more4
    NBP351
    53.89(n)1
    54.67(a)1
      7(343042-342056)4
    8527891, 4  NP_011424.31  NP_011424.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NBP351 NBP35 60.44(n)
    60.67(a)
      835169  NM_124475.4  NP_568748.1 
    rice
    (Oryza sativa)
    Liliopsida Os.3732 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.5(n)    AK120649.1 


    ENSEMBL Gene Tree for NUBP1 (if available)
    TreeFam Gene Tree for NUBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NUBP1 gene
    NUBPL2  
    2 SIMAP similar genes for NUBP1 using alignment to 5 protein entries:     NUBP1_HUMAN (see all proteins):
    NUBP2    NUBPL

    Find genes that share paralogs with NUBP1           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for NUBP1
    PGOHUM00000262178 PGOHUM00000251336


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NUBP1 (see all 650)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71933481,2
    C,F--10835701(+) taaaaA/Tcccag 1 -- us2k13Minor allele frequency- T:0.31WA CSA 122
    rs740075291,2
    C,F--10835759(+) CCATCT/GTATCA 1 -- us2k13Minor allele frequency- G:0.18WA CSA 122
    rs1873467231,2
    --10835833(+) CTTTGC/TTGATG 1 -- us2k10--------
    rs1414444211,2
    --10835864(+) TCTCCC/TGACCA 1 -- us2k10--------
    rs1906665291,2
    --10835868(+) CCGACC/TAGACT 1 -- us2k10--------
    rs1835915761,2
    --10836025(+) CTCGGA/GAAAGT 1 -- us2k10--------
    rs1881860781,2
    --10836032(+) AAGTAA/GTTTAC 1 -- us2k10--------
    rs11094461,2
    C,F--10836079(-) CATAGT/CCCtac 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1927770091,2
    --10836097(+) ATAAAC/TTAGGT 1 -- us2k10--------
    rs1826874541,2
    --10836109(+) ATTCAC/TATGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NUBP1 (10837643 - 10863208 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NUBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv368e201CNV Deletion23290073
    dgv367e201CNV Deletion23290073
    esv2713968CNV Deletion23290073
    esv2713967CNV Deletion23290073
    esv2713969CNV Deletion23290073
    esv988489CNV Deletion20482838
    nsv833140CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for NUBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 600280    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NUBP1:
    Syndactyly

    Find genes that share disorders with NUBP1           About GenesLikeMe

    Genetic Association Database (GAD): NUBP1
    Human Genome Epidemiology (HuGE) Navigator: NUBP1 (4 documents)

    Export disorders for NUBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NUBP1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with NUBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD. (PubMed id 7926816)1, 2, 3 Shahrestanifar M.... Howells R.D. (Gene 1994)
    2. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    3. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    4. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    5. Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis. (PubMed id 18573874)1, 2 Stehling O.... Lill R. (Mol. Cell. Biol. 2008)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4682 HGNC: 8041 AceView: NUBP1 Ensembl:ENSG00000103274 euGenes: HUgn4682
    ECgene: NUBP1 H-InvDB: NUBP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NUBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NUBP1 gene:
    Search GeneIP for patents involving NUBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NUBP1  
     OriGene qPCR primer pairs and template standards for NUBP1   OriGene Protein Over-expression Lysate for NUBP1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NUBP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NUBP1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NUBP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NUBP1   OriGene Custom Protein Services for NUBP1  

     
     
     Block miRNA regulation of human, mouse, rat NUBP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NUBP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUBP1 Predesigned siRNA for gene silencing in human, mouse, rat NUBP1
     QuantiFast Probe-based Assays in human, mouse, rat NUBP1 QuantiTect SYBR Green Assays in human, mouse, rat NUBP1
     Custom PCR Arrays for NUBP1 Search Chromatin IP Primers for NUBP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUBP1  Search GeneGlobe Interaction Network for NUBP1
     Regulatory tfbs in NUBP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NUBP1 GenScript cDNA clones with any tag delivered in your preferred vector for NUBP1
     GenScript Custom Assay Services for NUBP1 GenScript Custom overexpressing Cell Line Services for NUBP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NUBP1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for NUBP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NUBP1 antibodies
     NUBP1 proteins
     NUBP1 lysates
     Antibodies for NUBP1
     See all of Abcam's Antibodies, Kits and Proteins for NUBP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NUBP1
     Antibodies for NUBP1
     ELISAs for NUBP1
     CLIAs for NUBP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for NUBP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUBP1
     SwitchGear 3'UTR luciferase reporter plasmids for NUBP1
     SwitchGear Promoter luciferase reporter plasmids for NUBP1
     Search ThermoFisher Antibodies for NUBP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUBP1
     Browse compounds at ApexBio
     Search Addgene for plasmids for NUBP1
      Search eBioscience for proteins for NUBP1
      Search eBioscience for elisas for NUBP1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for NUBP1
     antibodies-online antibodies for NUBP1 (28 products)
     antibodies-online kits for NUBP1 (8 products)
     antibodies-online peptides for NUBP1
     antibodies-online proteins for NUBP1 (8 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NUBP1 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4