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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUBP1 Gene

protein-coding   GIFtS: 63
GCID: GC16P010837

Nucleotide Binding Protein 1

(Previous names: nucleotide binding protein 1 (E.coli MinD like), nucleotide...)
(Previous symbol: NBP1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nucleotide Binding Protein 11 2     Nucleotide-Binding Protein 12 3
NBP11 2 3     NBP 12 3
NBP2 3 5     Cytosolic Fe-S Cluster Assembly Factor NUBP12
Nucleotide Binding Protein 1 (E.Coli MinD Like)1 2     Nucleotide Binding Protein (E.Coli MinD Like)2
Nucleotide Binding Protein 1 (MinD Homolog, E. Coli)1 2     

External Ids:    HGNC: 80411   Entrez Gene: 46822   Ensembl: ENSG000001032747   OMIM: 6002805   UniProtKB: P533843   

Export aliases for NUBP1 gene to outside databases

Previous GC identifers: GC16P010631 GC16P010988 GC16P010804 GC16P010745 GC16P010756


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUBP1 Gene:
NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 (PubMed
10486206)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NUBP1 Gene: 
NUBP1 (nucleotide binding protein 1) is a protein-coding gene. Diseases associated with NUBP1 include syndactyly, and tuberculosis, and among its related super-pathways are Metabolic pathways. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and nucleotide binding. An important paralog of this gene is NUBPL.

UniProtKB/Swiss-Prot: NUBP1_HUMAN, P53384
Function: Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic
iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins.
The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster
and its transfer to target apoproteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUBP1 gene promoter:
         Egr-3   STAT1   C/EBPbeta   AML1a   STAT1beta   STAT5A   STAT1alpha   GATA-1   Egr-2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNUBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.13   Ensembl cytogenetic band:  16p13.13   HGNC cytogenetic band: 16p13.13

NUBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUBP1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P010837:  view genomic region     (about GC identifiers)

Start:
10,837,643 bp from pter      End:
10,863,208 bp from pter
Size:
25,566 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NUBP1_HUMAN, P53384 (See protein sequence)
Recommended Name: Cytosolic Fe-S cluster assembly factor NUBP1  
Size: 320 amino acids; 34534 Da
Cofactor: Binds 4 4Fe-4S clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and
two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer (By similarity)
Subunit: Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1 (By similarity). Interacts with NUBP2
Subcellular location: Cytoplasm
Secondary accessions: Q32M30 Q498A9 Q53FS7
Alternative splicing: 2 isoforms:  P53384-1   P53384-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUBP1: NX_P53384

Explore proteomics data for NUBP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P53384

  • NUBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NUBP1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001265435.1  NP_002475.2  

    ENSEMBL proteins: 
     ENSP00000461746   ENSP00000283027   ENSP00000409654   ENSP00000460288   ENSP00000461723  
    Reactome Protein details: P53384
    Human Recombinant Protein Products for NUBP1: 
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    Novus Biologicals NUBP1 Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NUBP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IDA18573874
    GO:0005886plasma membrane IDA--

    NUBP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR025723 Anion-transp_ATPase-like_dom
     IPR019591 ATPase-like_ParA/MinD
     IPR000808 Mrp_CS
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry P53384

    ProtoNet protein and cluster: P53384

    1 Blocks protein domain: IPB000808 Mrp family

    UniProtKB/Swiss-Prot: NUBP1_HUMAN, P53384
    Similarity: Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily


    NUBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUBP1_HUMAN, P53384
    Function: Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic
    iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins.
    The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster
    and its transfer to target apoproteins

         Genatlas biochemistry entry for NUBP1:
    nucleotide binding protein 1,homolog to the mrp gene of E. coli,MinD-like

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding TAS7926816
    GO:0005515protein binding IPI18573874
    GO:0005524ATP binding IEA--
    GO:0017111nucleoside-triphosphatase activity IEA--
    GO:0046872metal ion binding IEA--
         
    NUBP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NUBP1:
     Decreased number of cells in m 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nubp1):
     limbs/digits/tail  mortality/aging  respiratory system  vision/eye 

    NUBP1 for phenotypes           About GeneDecksing

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUBP1 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NUBP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    2Cytosolic Iron-sulfur Cluster Assembly
    Cytosolic Iron-sulfur Cluster Assembly

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2        Reactome Pathways for NUBP1
        Cytosolic Iron-sulfur Cluster Assembly
    Metabolism



    NUBP1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/16 Interacting proteins for NUBP1 (P533842, 3 ENSP000002830274) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPRY2O435972, 3, ENSP000003663064MINT-8272039 I2D: score=2 STRING: ENSP00000366306
    NUBP2Q9Y5Y23, ENSP000002623024I2D: score=7 STRING: ENSP00000262302
    NDNQ996083, ENSP000003326434I2D: score=2 STRING: ENSP00000332643
    NARFLQ9H6Q43, ENSP000002515884I2D: score=1 STRING: ENSP00000251588
    FRYLO949153I2D: score=4 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006879cellular iron ion homeostasis IMP18573874
    GO:0016049cell growth IMP18573874
    GO:0016226iron-sulfur cluster assembly IMP18573874
    GO:0044281small molecule metabolic process TAS--

    NUBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUBP1

    Search CenterWatch for drugs/clinical trials and news about NUBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NUBP1 gene (2 alternative transcripts): 
    NM_001278506.1  NM_002484.3  

    Unigene Cluster for NUBP1:

    Nucleotide binding protein 1
    Hs.81469  [show with all ESTs]
    Unigene Representative Sequence: NM_002484
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000574334 ENST00000571790 ENST00000574137(uc010bum.1) ENST00000283027(uc002daa.1 uc002dab.1)
    ENST00000433392 ENST00000571175 ENST00000574691 ENST00000573663
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate NUBP1:
    hsa-miR-593
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUBP1
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    Additional mRNA sequence: 

    AK223204.1 AK307148.1 AK310089.1 BC100290.1 BC109322.1 BC109323.1 U01833.1 

    10 DOTS entries:

    DT.444422  DT.100785305  DT.92427553  DT.95084779  DT.75160830  DT.92427552  DT.120682833  DT.101979088 
    DT.91976080  DT.95084766 

    24/135 AceView cDNA sequences (see all 135):

    CR622882 AA937737 AW404659 CB529463 AI733196 AL552009 BM799495 BQ063177 
    CB528598 CB142931 CD742985 AL551846 BX094774 CR600910 AL524488 BQ889231 
    CR613650 BX415664 BM423429 CR601815 CD366483 BU507248 AA369782 BM826703 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NUBP1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
    SP1:                                                                    -         
    SP2:                                                                              
    SP3:                                -                                             
    SP4:                          -                                                   
    SP5:                          -                                                   


    ECgene alternative splicing isoforms for NUBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUBP1 expression in normal human tissues (normalized intensities)      NUBP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCAGGACT
    NUBP1 Expression
    About this image


    NUBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             colon ; peripheral nerve/ganglion   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   

    See NUBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUBP1

    SOURCE GeneReport for Unigene cluster: Hs.81469
        SABiosciences Custom PCR Arrays for NUBP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUBP1 gene from 10/27 species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nubp11 , 5 nucleotide binding protein 11, 5 85.58(n)1
    89.34(a)1
      16 (5.61 cM)5
    264251  NM_011955.21  NP_036085.11 
     104119485 
    chicken
    (Gallus gallus)
    Aves NUBP11 nucleotide binding protein 1 74.42(n)
    79.94(a)
      416634  NM_001198641.1  NP_001185570.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUBP16
    nucleotide binding protein 1
    77(a)
    1 ↔ 1
    GL343592.1(308887-319617)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.160602 Xenopus laevis transcribed sequence with moderate similarity more 76.88(n)    CF547019.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.293992 Danio rerio cDNA clone IMAGE6794953, partial cds 78.58(n)    BC064668.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG179041 , 3 nucleotide binding3
    CG179041
    58(a)
    (best of 2)3
    61.01(n)1
    59.93(a)1
      36A123
    350001  NM_135961.31  NP_609805.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F10G8.61 , 3 nucleotide binding protein3
    Protein F10G8.61
    50(a)3
    57.89(n)1
    55.59(a)1
      I(10054503-10055928)3
    1728681  NM_060252.31  NP_492653.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NBP35(YGL091C)4
    NBP351
    Essential iron-sulfur cluster binding protein localized more4
    Nbp35p1
    53.89(n)1
    54.67(a)1
      7(343042-342056)4
    8527891, 4  NP_011424.31  NP_011424.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons NBP351 nucleotide binding protein 35 60.44(n)
    60.67(a)
      835169  NM_124475.4  NP_568748.1 
    rice
    (Oryza sativa)
    Liliopsida Os.3732 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 73.5(n)    AK120649.1 


    ENSEMBL Gene Tree for NUBP1 (if available)
    TreeFam Gene Tree for NUBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUBP1 gene
    NUBPL2  
    2 SIMAP similar genes for NUBP1 using alignment to 5 protein entries:     NUBP1_HUMAN (see all proteins):
    NUBP2    NUBPL

    NUBP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NUBP1
    PGOHUM00000262178 PGOHUM00000251336


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/650 SNPs in NUBP1 are shown (see all 650)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71933481,2
    C,F--10835701(+) taaaaA/Tcccag 1 -- us2k13Minor allele frequency- T:0.31WA CSA 122
    rs740075291,2
    C,F--10835759(+) CCATCT/GTATCA 1 -- us2k13Minor allele frequency- G:0.18WA CSA 122
    rs1873467231,2
    --10835833(+) CTTTGC/TTGATG 1 -- us2k10--------
    rs1414444211,2
    --10835864(+) TCTCCC/TGACCA 1 -- us2k10--------
    rs1906665291,2
    --10835868(+) CCGACC/TAGACT 1 -- us2k10--------
    rs1835915761,2
    --10836025(+) CTCGGA/GAAAGT 1 -- us2k10--------
    rs1881860781,2
    --10836032(+) AAGTAA/GTTTAC 1 -- us2k10--------
    rs11094461,2
    C,F--10836079(-) CATAGT/CCCtac 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1927770091,2
    --10836097(+) ATAAAC/TTAGGT 1 -- us2k10--------
    rs1826874541,2
    --10836109(+) ATTCAC/TATGAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NUBP1 (10837643 - 10863208 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for NUBP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv368e201CNV Deletion23290073
    dgv367e201CNV Deletion23290073
    esv2713968CNV Deletion23290073
    esv2713967CNV Deletion23290073
    esv2713969CNV Deletion23290073
    esv988489CNV Deletion20482838
    nsv833140CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600280    OMIM disorders: --

    5 diseases for NUBP1:    About MalaCards
    syndactyly    tuberculosis    colon cancer    lung cancer
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NUBP1:
    Syndactyly

    NUBP1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NUBP1
    Human Genome Epidemiology (HuGE) Navigator: NUBP1 (4 documents)

    Export disorders for NUBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUBP1 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with NUBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD. (PubMed id 7926816)1, 2, 3 Shahrestanifar M.... Howells R.D. (1994)
    2. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (2009)
    3. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    4. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (2008)
    5. Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis. (PubMed id 18573874)1, 2 Stehling O....Lill R. (2008)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4682 HGNC: 8041 AceView: NUBP1 Ensembl:ENSG00000103274 euGenes: HUgn4682
    ECgene: NUBP1 H-InvDB: NUBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NUBP1 gene:
    Search GeneIP for patents involving NUBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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