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Aliases for NUBP1 Gene

Aliases for NUBP1 Gene

  • Nucleotide Binding Protein 1 2 3
  • NBP 3 4 6
  • Nucleotide Binding Protein 1 (MinD Homolog, E. Coli) 2 3
  • Nucleotide Binding Protein 1 (E.Coli MinD Like) 2 3
  • Nucleotide-Binding Protein 1 3 4
  • NBP 1 3 4
  • NBP1 3 4
  • Nucleotide Binding Protein (E.Coli MinD Like) 3
  • Cytosolic Fe-S Cluster Assembly Factor NUBP1 3
  • NBP35 3

External Ids for NUBP1 Gene

Previous Symbols for NUBP1 Gene

  • NBP1

Summaries for NUBP1 Gene

Entrez Gene Summary for NUBP1 Gene

  • NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NUBP1 Gene

NUBP1 (Nucleotide Binding Protein 1) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic Iron-sulfur Cluster Assembly. GO annotations related to this gene include nucleotide binding and 4 iron, 4 sulfur cluster binding. An important paralog of this gene is NUBPL.

UniProtKB/Swiss-Prot for NUBP1 Gene

  • Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUBP1 Gene

Genomics for NUBP1 Gene

Genomic Location for NUBP1 Gene

Start:
10,743,786 bp from pter
End:
10,769,351 bp from pter
Size:
25,566 bases
Orientation:
Plus strand

Genomic View for NUBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUBP1 Gene

Regulatory Elements for NUBP1 Gene

Proteins for NUBP1 Gene

  • Protein details for NUBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53384-NUBP1_HUMAN
    Recommended name:
    Cytosolic Fe-S cluster assembly factor NUBP1
    Protein Accession:
    P53384
    Secondary Accessions:
    • Q32M30
    • Q498A9
    • Q53FS7

    Protein attributes for NUBP1 Gene

    Size:
    320 amino acids
    Molecular mass:
    34534 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.;
    Quaternary structure:
    • Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1 (By similarity). Interacts with NUBP2.

    Alternative splice isoforms for NUBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUBP1 Gene

Proteomics data for NUBP1 Gene at MOPED

Post-translational modifications for NUBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUBP1 Gene

No data available for DME Specific Peptides for NUBP1 Gene

Domains for NUBP1 Gene

Protein Domains for NUBP1 Gene

UniProtKB/Swiss-Prot:

NUBP1_HUMAN
Family:
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.:
    • P53384
genes like me logo Genes that share domains with NUBP1: view

No data available for Gene Families for NUBP1 Gene

Function for NUBP1 Gene

Molecular function for NUBP1 Gene

GENATLAS Biochemistry: nucleotide binding protein 1,homolog to the mrp gene of E. coli,MinD-like
UniProtKB/Swiss-Prot Function: Implicated in the regulation of centrosome duplication (By similarity). Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.

Gene Ontology (GO) - Molecular Function for NUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding TAS 7926816
GO:0005515 protein binding IPI 18573874
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
GO:0051536 iron-sulfur cluster binding IDA 18573874
genes like me logo Genes that share ontologies with NUBP1: view
genes like me logo Genes that share phenotypes with NUBP1: view

miRNA for NUBP1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUBP1 Gene

Localization for NUBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUBP1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUBP1 Gene COMPARTMENTS Subcellular localization image for NUBP1 gene
Compartment Confidence
cytosol 5
plasma membrane 4
nucleus 1

Gene Ontology (GO) - Cellular Components for NUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IDA 18573874
GO:0005886 plasma membrane IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NUBP1: view

Pathways for NUBP1 Gene

genes like me logo Genes that share pathways with NUBP1: view

Pathways by source for NUBP1 Gene

2 Reactome pathways for NUBP1 Gene

Gene Ontology (GO) - Biological Process for NUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006879 cellular iron ion homeostasis IMP 18573874
GO:0010826 negative regulation of centrosome duplication IEA --
GO:0016049 cell growth IMP 18573874
GO:0016226 iron-sulfur cluster assembly IMP 18573874
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NUBP1: view

Transcripts for NUBP1 Gene

Unigene Clusters for NUBP1 Gene

Nucleotide binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: -
SP2:
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for NUBP1 Gene

GeneLoc Exon Structure for
NUBP1
ECgene alternative splicing isoforms for
NUBP1

Expression for NUBP1 Gene

mRNA expression in normal human tissues for NUBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUBP1 Gene

SOURCE GeneReport for Unigene cluster for NUBP1 Gene Hs.81469

genes like me logo Genes that share expressions with NUBP1: view

Orthologs for NUBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUBP1 36
  • 98.86 (n)
  • 98.63 (a)
NUBP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUBP1 36
  • 86.98 (n)
  • 90.31 (a)
NUBP1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUBP1 36
  • 88.23 (n)
  • 90.94 (a)
NUBP1 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nubp1 36
  • 85.58 (n)
  • 89.34 (a)
Nubp1 16
Nubp1 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUBP1 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUBP1 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nubp1 36
  • 86 (n)
  • 87.77 (a)
chicken
(Gallus gallus)
Aves NUBP1 36
  • 74.42 (n)
  • 79.94 (a)
NUBP1 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUBP1 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16060 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nubp1 36
  • 74.59 (n)
  • 83.17 (a)
Str.1794 36
zebrafish
(Danio rerio)
Actinopterygii Dr.29399 36
nubp1 36
  • 72.08 (n)
  • 77.07 (a)
nubp1 37
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NUBP1_ANOGA 36
  • 61.13 (n)
  • 60.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17904 36
  • 60.93 (n)
  • 59.5 (a)
CG17904 37
  • 54 (a)
OneToOne
CG17904 38
  • 58 (a)
CG4858 38
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea F10G8.6 36
  • 57.79 (n)
  • 55.59 (a)
nubp-1 37
  • 52 (a)
OneToOne
F10G8.6 38
  • 50 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL060W 36
  • 58.86 (n)
  • 54.85 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NBP35 36
  • 53.89 (n)
  • 54.67 (a)
NBP35 37
  • 50 (a)
OneToMany
NBP35 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18987g 36
  • 56.44 (n)
  • 55.12 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons NBP35 36
  • 60.44 (n)
  • 60.67 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2749 36
corn
(Zea mays)
Liliopsida Zm.2864 36
rice
(Oryza sativa)
Liliopsida Os.373 36
Os02g0601100 36
  • 52.6 (n)
  • 40.62 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14507 36
bread mold
(Neurospora crassa)
Ascomycetes NCU08825 36
  • 58.17 (n)
  • 58.72 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC637.08 36
  • 57.55 (n)
  • 60.26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1878 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 61 (a)
OneToOne
Species with no ortholog for NUBP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NUBP1 Gene

ENSEMBL:
Gene Tree for NUBP1 (if available)
TreeFam:
Gene Tree for NUBP1 (if available)

Paralogs for NUBP1 Gene

Paralogs for NUBP1 Gene

Selected SIMAP similar genes for NUBP1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NUBP1 Gene

genes like me logo Genes that share paralogs with NUBP1: view

Variants for NUBP1 Gene

Sequence variations from dbSNP and Humsavar for NUBP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1084546 -- 10,758,317(-) TTTAA(A/C)ATATT intron-variant
rs1084547 -- 10,757,503(-) tggtg(C/T)agaac intron-variant
rs1084552 -- 10,747,749(-) CTTGG(C/G)TAGGG intron-variant
rs1084553 -- 10,747,676(-) CCAAA(C/G)AGGCC intron-variant
rs1084561 -- 10,745,684(-) gccac(A/G)aggcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUBP1 Gene

Variant ID Type Subtype PubMed ID
nsv833140 CNV Loss 17160897
esv2713967 CNV Deletion 23290073
esv2713968 CNV Deletion 23290073
esv2713969 CNV Deletion 23290073
esv988489 CNV Deletion 20482838
dgv367e201 CNV Deletion 23290073
dgv368e201 CNV Deletion 23290073

Relevant External Links for NUBP1 Gene

HapMap Linkage Disequilibrium report
NUBP1

Disorders for NUBP1 Gene

(1) University of Copenhagen DISEASES for NUBP1 Gene

Relevant External Links for NUBP1

Genetic Association Database (GAD)
NUBP1
Human Genome Epidemiology (HuGE) Navigator
NUBP1
genes like me logo Genes that share disorders with NUBP1: view

No data available for UniProtKB/Swiss-Prot for NUBP1 Gene

Publications for NUBP1 Gene

  1. Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD. (PMID: 7926816) Shahrestanifar M. … Howells R.D. (Gene 1994) 2 3 4
  2. Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis. (PMID: 18573874) Stehling O. … Lill R. (Mol. Cell. Biol. 2008) 3 4
  3. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PMID: 18676680) Hosgood H.D. … Lan Q. (Carcinogenesis 2008) 3 49
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 49
  5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 49

Products for NUBP1 Gene

Sources for NUBP1 Gene

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