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Aliases for NUBP1 Gene

Aliases for NUBP1 Gene

  • Nucleotide Binding Protein 1 2 3 5
  • Nucleotide Binding Protein 1 (MinD Homolog, E. Coli) 2 3
  • Nucleotide Binding Protein 1 (E.Coli MinD Like) 2 3
  • Nucleotide-Binding Protein 1 3 4
  • NBP 1 3 4
  • NBP1 3 4
  • NBP 3 4
  • Nucleotide Binding Protein (E.Coli MinD Like) 3
  • NBP35 3

External Ids for NUBP1 Gene

Previous HGNC Symbols for NUBP1 Gene

  • NBP1

Previous GeneCards Identifiers for NUBP1 Gene

  • GC16P010631
  • GC16P010988
  • GC16P010804
  • GC16P010745
  • GC16P010837
  • GC16P010756

Summaries for NUBP1 Gene

Entrez Gene Summary for NUBP1 Gene

  • NUBP1 is a member of the NUBP/MRP subfamily of ATP-binding proteins (Nakashima et al., 1999 [PubMed 10486206]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NUBP1 Gene

NUBP1 (Nucleotide Binding Protein 1) is a Protein Coding gene. Among its related pathways are Metabolism and Cytosolic iron-sulfur cluster assembly. GO annotations related to this gene include nucleotide binding and iron-sulfur cluster binding. An important paralog of this gene is NUBPL.

UniProtKB/Swiss-Prot for NUBP1 Gene

  • Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUBP1 Gene

Genomics for NUBP1 Gene

Regulatory Elements for NUBP1 Gene

Enhancers for NUBP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NUBP1 on UCSC Golden Path with GeneCards custom track

Promoters for NUBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NUBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NUBP1 Gene

Chromosome:
16
Start:
10,743,321 bp from pter
End:
10,769,351 bp from pter
Size:
26,031 bases
Orientation:
Plus strand

Genomic View for NUBP1 Gene

Genes around NUBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NUBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NUBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUBP1 Gene

Proteins for NUBP1 Gene

  • Protein details for NUBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53384-NUBP1_HUMAN
    Recommended name:
    Cytosolic Fe-S cluster assembly factor NUBP1
    Protein Accession:
    P53384
    Secondary Accessions:
    • Q32M30
    • Q498A9
    • Q53FS7

    Protein attributes for NUBP1 Gene

    Size:
    320 amino acids
    Molecular mass:
    34534 Da
    Cofactor:
    Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
    Quaternary structure:
    • Heterotetramer of 2 NUBP1 and 2 NUBP2 chains (By similarity). Interacts with KIFC1 (By similarity). Interacts with NUBP2 (PubMed:18573874). Interacts with the BBS/CCT complex subunit CCT1 (By similarity).

    Alternative splice isoforms for NUBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NUBP1 Gene

Proteomics data for NUBP1 Gene at MOPED

Post-translational modifications for NUBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for NUBP1

No data available for DME Specific Peptides for NUBP1 Gene

Domains & Families for NUBP1 Gene

Gene Families for NUBP1 Gene

Protein Domains for NUBP1 Gene

Suggested Antigen Peptide Sequences for NUBP1 Gene

Graphical View of Domain Structure for InterPro Entry

P53384

UniProtKB/Swiss-Prot:

NUBP1_HUMAN :
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
Family:
  • Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.
genes like me logo Genes that share domains with NUBP1: view

Function for NUBP1 Gene

Molecular function for NUBP1 Gene

GENATLAS Biochemistry:
nucleotide binding protein 1,homolog to the mrp gene of E. coli,MinD-like
UniProtKB/Swiss-Prot Function:
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity).

Gene Ontology (GO) - Molecular Function for NUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18573874
genes like me logo Genes that share ontologies with NUBP1: view

Phenotypes for NUBP1 Gene

genes like me logo Genes that share phenotypes with NUBP1: view

Animal Models for NUBP1 Gene

MGI Knock Outs for NUBP1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NUBP1 Gene

Localization for NUBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUBP1 Gene

Cytoplasm. Nucleus. Cell projection. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis. Localized at centrioles and in the nucleus at interphase. Colocalizes with nubp-2 at prometaphase. Specifically localizes to the axenome of motile cilia as opposed to primary non-motile cilia. Localization is independent of NUBP2 and KIFC1. {ECO:0000250 UniProtKB:Q9R060}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUBP1 Gene COMPARTMENTS Subcellular localization image for NUBP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
plasma membrane 5
nucleus 4

Gene Ontology (GO) - Cellular Components for NUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005814 centriole IEA --
genes like me logo Genes that share ontologies with NUBP1: view

Pathways & Interactions for NUBP1 Gene

genes like me logo Genes that share pathways with NUBP1: view

Pathways by source for NUBP1 Gene

2 Reactome pathways for NUBP1 Gene

Gene Ontology (GO) - Biological Process for NUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010826 negative regulation of centrosome duplication IEA --
GO:0016049 cell growth IMP 18573874
GO:0016226 iron-sulfur cluster assembly IMP 18573874
GO:0030030 cell projection organization IEA --
genes like me logo Genes that share ontologies with NUBP1: view

No data available for SIGNOR curated interactions for NUBP1 Gene

Drugs & Compounds for NUBP1 Gene

No Compound Related Data Available

Transcripts for NUBP1 Gene

Unigene Clusters for NUBP1 Gene

Nucleotide binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUBP1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: -
SP2:
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for NUBP1 Gene

GeneLoc Exon Structure for
NUBP1
ECgene alternative splicing isoforms for
NUBP1

Expression for NUBP1 Gene

mRNA expression in normal human tissues for NUBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NUBP1 Gene

This gene is overexpressed in Lymph node (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUBP1 Gene



SOURCE GeneReport for Unigene cluster for NUBP1 Gene Hs.81469

genes like me logo Genes that share expression patterns with NUBP1: view

Protein tissue co-expression partners for NUBP1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NUBP1 Gene

Orthologs for NUBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NUBP1 35
  • 86.98 (n)
  • 90.31 (a)
NUBP1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUBP1 35
  • 88.23 (n)
  • 90.94 (a)
NUBP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nubp1 35
  • 85.58 (n)
  • 89.34 (a)
Nubp1 16
Nubp1 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUBP1 35
  • 98.86 (n)
  • 98.63 (a)
NUBP1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nubp1 35
  • 86 (n)
  • 87.77 (a)
oppossum
(Monodelphis domestica)
Mammalia NUBP1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUBP1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUBP1 35
  • 74.42 (n)
  • 79.94 (a)
NUBP1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUBP1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nubp1 35
  • 74.59 (n)
  • 83.17 (a)
Str.1794 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16060 35
zebrafish
(Danio rerio)
Actinopterygii Dr.29399 35
nubp1 35
  • 72.08 (n)
  • 77.07 (a)
nubp1 36
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17904 37
  • 58 (a)
CG4858 37
  • 48 (a)
CG17904 35
  • 60.93 (n)
  • 59.5 (a)
CG17904 36
  • 54 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta NUBP1_ANOGA 35
  • 61.13 (n)
  • 60.47 (a)
worm
(Caenorhabditis elegans)
Secernentea F10G8.6 37
  • 50 (a)
F10G8.6 35
  • 57.79 (n)
  • 55.59 (a)
nubp-1 36
  • 52 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL060W 35
  • 58.86 (n)
  • 54.85 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E18987g 35
  • 56.44 (n)
  • 55.12 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NBP35 35
  • 53.89 (n)
  • 54.67 (a)
NBP35 36
  • 50 (a)
OneToMany
NBP35 38
thale cress
(Arabidopsis thaliana)
eudicotyledons NBP35 35
  • 60.44 (n)
  • 60.67 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2749 35
rice
(Oryza sativa)
Liliopsida Os.373 35
Os02g0601100 35
  • 52.6 (n)
  • 40.62 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14507 35
corn
(Zea mays)
Liliopsida Zm.2864 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1878 35
bread mold
(Neurospora crassa)
Ascomycetes NCU08825 35
  • 58.17 (n)
  • 58.72 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC637.08 35
  • 57.55 (n)
  • 60.26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToOne
Species with no ortholog for NUBP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NUBP1 Gene

ENSEMBL:
Gene Tree for NUBP1 (if available)
TreeFam:
Gene Tree for NUBP1 (if available)

Paralogs for NUBP1 Gene

Paralogs for NUBP1 Gene

(2) SIMAP similar genes for NUBP1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NUBP1 Gene

genes like me logo Genes that share paralogs with NUBP1: view

Variants for NUBP1 Gene

Sequence variations from dbSNP and Humsavar for NUBP1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_020359 -
rs8063715 -- 10,745,038(+) caggc(A/G)tgagc intron-variant
rs9673828 -- 10,752,134(+) GACTC(A/C)TGAAC intron-variant
rs4780323 -- 10,746,990(+) TATTT(C/G)TACCA intron-variant
rs4780993 -- 10,748,749(-) CCTTA(A/C/G/T)AGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUBP1 Gene

Variant ID Type Subtype PubMed ID
nsv833140 CNV Loss 17160897
esv2713967 CNV Deletion 23290073
esv2713968 CNV Deletion 23290073
esv2713969 CNV Deletion 23290073
esv988489 CNV Deletion 20482838
dgv367e201 CNV Deletion 23290073
dgv368e201 CNV Deletion 23290073

Variation tolerance for NUBP1 Gene

Residual Variation Intolerance Score: 65.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.87; 74.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NUBP1 Gene

Disorders for NUBP1 Gene

Relevant External Links for NUBP1

Genetic Association Database (GAD)
NUBP1
Human Genome Epidemiology (HuGE) Navigator
NUBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUBP1

No disorders were found for NUBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUBP1 Gene

Publications for NUBP1 Gene

  1. Cloning of a human cDNA encoding a putative nucleotide-binding protein related to Escherichia coli MinD. (PMID: 7926816) Shahrestanifar M. … Howells R.D. (Gene 1994) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3

Products for NUBP1 Gene

Sources for NUBP1 Gene

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