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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NUB1 Gene

protein-coding GIFtS: 55
GCID: GC07P151038

negative regulator of ubiquitin-like proteins 1

Explore 11 diseases affiliated with
NUB1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Negative Regulator Of Ubiquitin-Like Proteins 1¹ ² ³		NUB1L²
NYREN18¹ ² ³		NEDD8 Ultimate Buster 1²
BS4¹ ²		NEDD8 Ultimate Buster-1²
Renal Carcinoma Antigen NY-REN-18² ³

External Ids:	HGNC: 17623¹	Entrez Gene: 51667²	Ensembl: ENSG00000013374⁷	OMIM: 607981⁵	UniProtKB: Q9Y5A7³

Export aliases for NUB1 gene to outside databases

Previous GC identifers: GC07P150669 GC07P144850

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUB1:

This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates

with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates

the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for

degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital

amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may

contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and

dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal

accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple

transcript variants. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: NUB1_HUMAN, Q9Y5A7

Function: Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the

proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2

Gene Wiki entry for NUB1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NUB1 gene promoter:
ER-alpha STAT1 Pbx1a Pax-5 STAT1beta GATA-1 c-Ets-1 GATA-2 STAT1alpha IRF-7A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NUB1 promoter sequence

Search SABiosciences Chromatin IP Primers for NUB1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUB1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36

NUB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUB1 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P151038: view genomic region (about GC identifiers)

Start:	151,038,785 bp from pter	End:	151,075,535 bp from pter
Size:	36,751 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 150,368,365-150,404,899

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NUB1_HUMAN, Q9Y5A7 (See protein sequence)

Recommended Name: NEDD8 ultimate buster 1

Size: 615 amino acids; 70538 Da

Subunit: Directly interacts with NEDD8 and PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome. Isoform

1 binds to NEDD8 more efficiently than isoform 2. Interacts with AIPL1. The interaction with UBD via UBA domains

facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates UBD degradation and

that of its conjugates

Subcellular location: Nucleus. Note=Predominantly nuclear

Sequence caution: Sequence=AAD42865.1; Type=Frameshift; Positions=365, 393;

1 PDB 3D structure from and Proteopedia for NUB1:

1WJU (3D)

Secondary accessions: O95422 Q75MR9 Q8IX22 Q9BXR2

Alternative splicing: 2 isoforms: Q9Y5A7-1 Q9Y5A7-2

Explore the universe of human proteins at neXtProt for NUB1: NX_Q9Y5A7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y5A7

NUB1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001230280.1 NP_057202.3

ENSEMBL proteins:

ENSP00000398644 ENSP00000454264 ENSP00000420638 ENSP00000418234 ENSP00000420086

ENSP00000420023 ENSP00000420344 ENSP00000419679 ENSP00000348110 ENSP00000457628

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	Uscn Proteins for NUB1

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

NUB1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NUB1 for domains About GeneDecksing

3 InterPro domains/families:

IPR009060 UBA-like

IPR000449 UBA/transl_elong_EF1B_N

IPR015940 UBA/transl_elong_EF1B_N_euk

Graphical View of Domain Structure for InterPro Entry Q9Y5A7

ProtoNet protein and cluster: Q9Y5A7

1 Blocks protein family: IPB000449 Ubiquitin-associated domain

UniProtKB/Swiss-Prot: NUB1_HUMAN, Q9Y5A7

Similarity: Contains 3 UBA domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NUB1_HUMAN, Q9Y5A7

Function: Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the

proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2

Induction: By TNF, IFNG/IFN-gamma and IFNB1/IFN-beta

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In Situ Assay
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16707496

NUB1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NUB1:

Synthetic lethal with Ras

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NUB1

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

5/21 Interacting proteins for NUB1 (Q9Y5A7^{2, 3} ENSP00000398644⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NEDD8	Q15843²^,³, ENSP00000250495⁴	MINT-50774 MINT-50772 MINT-50773 I2D: score=1 STRING: ENSP00000250495
FANCA	O15360³, ENSP00000373952⁴	I2D: score=1 STRING: ENSP00000373952
PSMD4	P55036³, ENSP00000357879⁴	I2D: score=1 STRING: ENSP00000357879
TP53	P04637³, ENSP00000269305⁴	I2D: score=1 STRING: ENSP00000269305
AIPL1	Q9NZN9³, ENSP00000370521⁴	I2D: score=2 STRING: ENSP00000370521

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006511	ubiquitin-dependent protein catabolic process	IMP	16707496
GO:0016567	protein ubiquitination	IMP	16707496
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	16707496
GO:0034341	response to interferon-gamma	IEP	16707496
GO:0034612	response to tumor necrosis factor	IEP	16707496

NUB1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NUB1
Search CenterWatch for drugs/clinical trials and news about NUB1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NUB1 gene (2 alternative transcripts):

NM_001243351.1 NM_016118.4

Unigene Cluster for NUB1:

Negative regulator of ubiquitin-like proteins 1

Hs.647082 [show with all ESTs]

Unigene Representative Sequence: NM_001243351

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000413040(uc022aqc.1 uc003wjw.3) ENST00000568733(uc003wjx.3)

ENST00000468404(uc003wjy.3 uc011kvj.1) ENST00000470229 ENST00000483358

ENST00000470316 ENST00000493588 ENST00000480907 ENST00000477666 ENST00000497987

ENST00000460712 ENST00000480714 ENST00000355851 ENST00000566856

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		hsa-miR-890 hsa-miR-2355-5p
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Additional cDNA sequence:

AF155099.1 AF300717.1 AF459743.1 AK026433.1 AK056624.1 AK127717.1 AK293159.1 AY129295.1

BC034716.2 BC046354.2

12 DOTS entries:

DT.40223582 DT.100832633 DT.214240 DT.100819293 DT.100819291 DT.95258505 DT.97778788 DT.97826153

DT.95310268 DT.95107575 DT.92414583 DT.91923860

24/285 AceView cDNA sequences (see all 285):

CF264851 AI434747 AL559393 BE885906 CR593223 BM967025 F28955 CR592734

CR611732 AI222845 AA336508 BM751744 AA723820 AI285088 CR626423 BM475611

BM791647 AA357542 AI318418 CR607018 BF916597 AA386312 AI340165 BG754814

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NUB1 (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b
SP1:									-		-
SP2:									-		-										-
SP3:					-				-		-
SP4:
SP5:																											-

ECgene alternative splicing isoforms for NUB1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NUB1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGAGCCGGC

About this image

NUB1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Cerebral Cortex

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NUB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NUB1

SOURCE GeneReport for Unigene cluster: Hs.647082

UniProtKB/Swiss-Prot: NUB1_HUMAN, Q9Y5A7

Tissue specificity: Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver,

prostate and skeletal muscle for isoform 2

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUB1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUB1 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nub1^{1 , 5}	negative regulator of ubiquitin-like proteins 1^{1, 5}	82.97(n)¹ 87.31(a)¹		5 (11.93 cM)⁵ 53312¹ NM_016736.2¹ NP_058016.2¹ 24685815⁵
chicken (Gallus gallus)	Aves	NUB1¹	negative regulator of ubiquitin-like proteins 1	67.46(n) 65.48(a)		420433 XM_418538.3 XP_418538.2
lizard (Anolis carolinensis)	Reptilia	NUB1⁶	--	62(a)	1 ↔ 1	6(3850462-3862411)
zebrafish (Danio rerio)	Actinopterygii	nub1¹	negative regulator of ubiquitin-like proteins 1	51.45(n) 40.97(a)		557021 NM_001113580.1 NP_001107052.1
fruit fly (Drosophila melanogaster)	Insecta	CG15445¹	CG15445	43.62(n) 31.56(a)		33094 NM_134592.2 NP_608436.3
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G12550¹	ubiquitin-associated (UBA)/TS-N domain-containing protein	42.06(n) 27.92(a)		815729 NM_126895.3 NP_178939.2
rice (Oryza sativa)	Liliopsida	--	UBA/TS-N domain containing protein, expressed	21(a)	1 ↔ 1	4(32603602-32609055)

ENSEMBL Gene Tree for NUB1 (if available)
TreeFam Gene Tree for NUB1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs367357^1,2	C,F	--	144860669(+)	`GTAAAT/Acacac`	2	--	int¹		1		EA	1486
rs115425022^1,2	C,F,	--	150366817(+)	`AAAATG/TTCAGA`	2	--	us2k¹		1		WA	118
rs2429249^1,2	C,F,H,	--	150366876(-)	`AAAAGC/TCCGTT`	2	--	us2k¹		7		NS NA WA	1010
rs112679882^1,2		--	150367416(+)	`ATTCAT/AGAATC`	2	--	us2k¹		1		CSA	2
rs77891615^1,2		--	150367588(+)	`GTGGTG/ATGTCC`	2	--	us2k¹		3		CSA WA	120
rs73472479^1,2	C,	--	150367898(+)	`GCAGCC/TTAATT`	2	--	us2k¹		2		WA	120
rs59356301^1,2		--	150367957(+)	`CCGCTC/GGTTTA`	2	--	us2k¹		0	--	--	--	--
rs113920358^1,2	C,	--	150368394(+)	`GCTGCC/TGCATC`	4	R C	mis¹		4		NA CSA EA	243
rs10085614^1,2	C,	--	150368528(+)	`TCTCCT/CGGCCA`	2	--	int¹		5		NA EA MN	524
rs62490272^1,2	C,	--	150368686(+)	`GGGTAT/CTTAAA`	2	--	int¹		3		NA EA	242

HapMap Linkage Disequilibrium report for NUB1 (151038785 - 151075535 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NUB1
2 Indels: 28492 41941

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NUB1

DNA2.0 Custom Variant and Variant Library Synthesis for NUB1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NUB1 for disorders           About GeneDecksing

OMIM gene information: 607981    OMIM disorders: --

11 diseases for NUB1:    About MalaCards

leber congenital amaurosis renal carcinoma multiple system atrophy parkinson's disease

carcinoma dementia fanconi's anemia renal cell carcinoma

anemia blindness prostatitis

1 disease from the University of Copenhagen DISEASES database for NUB1:

Leber congenital amaurosis

1 Novoseek disease relationship for NUB1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lebers congenital amaurosis	90.2	3	15081406 (1), 15347646 (1)

Export disorders for NUB1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NUB1 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with NUB1)

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NUB1, a NEDD8-interacting protein, is induced by interferon and down- regulates the NEDD8 expression. (PubMed id 11259415)^{1, 2, 3, 9} Kito K.... Kamitani T. (2001)
Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)^{1, 2, 3} Scanlan M.J....Old L.J. (1999)
The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1. (PubMed id 12374762)^{1, 2, 9} Akey D.T....Sohocki M.M. (2002)
The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10. (PubMed id 16707496)^{1, 2} Schmidtke G....Groettrup M. (2006)
NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation. (PubMed id 14757770)^{1, 2} Hipp M.S....Schmidtke G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L. (PubMed id 12816948)^{1, 2} Tanaka T.... Kamitani T. (2003)
Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1. (PubMed id 11585840)^{1, 2} Kamitani T.... Yeh E.T.H. (2001)
The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments. (PubMed id 15347646)^{1, 9} van der Spuy J. and Cheetham M.E. (2004)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51667	HGNC: 17623	AceView: NYREN18	Ensembl:ENSG00000013374	euGenes: HUgn51667
ECgene: NUB1	H-InvDB: NUB1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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PharmGKB entry for NUB1	Pharmacogenomics, SNPs, Pathways

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negative regulator of ubiquitin-like proteins 1

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negative regulator of ubiquitin-like proteins 1

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