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Aliases for NUB1 Gene

Aliases for NUB1 Gene

  • Negative Regulator Of Ubiquitin-Like Proteins 1 2 3 4
  • Renal Carcinoma Antigen NY-REN-18 3 4
  • NEDD8 Ultimate Buster-1 2 3
  • NYREN18 3 4
  • NEDD8 Ultimate Buster 1 3
  • NUB1L 3
  • BS4 3

External Ids for NUB1 Gene

Summaries for NUB1 Gene

Entrez Gene Summary for NUB1 Gene

  • This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for NUB1 Gene

NUB1 (Negative Regulator Of Ubiquitin-Like Proteins 1) is a Protein Coding gene. Diseases associated with NUB1 include synucleinopathy and multiple system atrophy.

UniProtKB/Swiss-Prot for NUB1 Gene

  • Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.

Gene Wiki entry for NUB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUB1 Gene

Genomics for NUB1 Gene

Genomic Location for NUB1 Gene

151,341,699 bp from pter
151,378,461 bp from pter
36,763 bases
Plus strand

Genomic View for NUB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUB1 Gene

Regulatory Elements for NUB1 Gene

Proteins for NUB1 Gene

  • Protein details for NUB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NEDD8 ultimate buster 1
    Protein Accession:
    Secondary Accessions:
    • O95422
    • Q75MR9
    • Q8IX22
    • Q9BXR2

    Protein attributes for NUB1 Gene

    615 amino acids
    Molecular mass:
    70538 Da
    Quaternary structure:
    • Directly interacts with NEDD8 and PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome. Isoform 1 binds to NEDD8 more efficiently than isoform 2. Interacts with AIPL1. The interaction with UBD via UBA domains facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates UBD degradation and that of its conjugates.
    • Sequence=AAD42865.1; Type=Frameshift; Positions=365, 393; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUB1 Gene

    Alternative splice isoforms for NUB1 Gene


neXtProt entry for NUB1 Gene

Proteomics data for NUB1 Gene at MOPED

Post-translational modifications for NUB1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys10, Lys167, Lys312, and Lys371

No data available for DME Specific Peptides for NUB1 Gene

Domains for NUB1 Gene

Protein Domains for NUB1 Gene


  • Contains 3 UBA domains.:
    • Q9Y5A7
genes like me logo Genes that share domains with NUB1: view

No data available for Gene Families for NUB1 Gene

Function for NUB1 Gene

Molecular function for NUB1 Gene

UniProtKB/Swiss-Prot Function: Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.
UniProtKB/Swiss-Prot Induction: By TNF, IFNG/IFN-gamma and IFNB1/IFN-beta.

Gene Ontology (GO) - Molecular Function for NUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12374762
genes like me logo Genes that share ontologies with NUB1: view

Phenotypes for NUB1 Gene

GenomeRNAi human phenotypes for NUB1:
genes like me logo Genes that share phenotypes with NUB1: view

miRNA for NUB1 Gene

miRTarBase miRNAs that target NUB1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUB1 Gene

Localization for NUB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUB1 Gene

Nucleus. Note=Predominantly nuclear.

Subcellular locations from

Jensen Localization Image for NUB1 Gene COMPARTMENTS Subcellular localization image for NUB1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NUB1: view

Pathways for NUB1 Gene

SuperPathways for NUB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NUB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IMP 16707496
GO:0016567 protein ubiquitination IMP 16707496
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP 16707496
GO:0034341 response to interferon-gamma IEP 16707496
GO:0034612 response to tumor necrosis factor IEP 16707496
genes like me logo Genes that share ontologies with NUB1: view

No data available for Pathways by source for NUB1 Gene

Transcripts for NUB1 Gene

Unigene Clusters for NUB1 Gene

Negative regulator of ubiquitin-like proteins 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUB1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1: - -
SP2: - - -
SP3: - - -
SP5: -
SP7: -

Relevant External Links for NUB1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NUB1 Gene

mRNA expression in normal human tissues for NUB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NUB1 Gene

SOURCE GeneReport for Unigene cluster for NUB1 Gene Hs.647082

mRNA Expression by UniProt/SwissProt for NUB1 Gene

Tissue specificity: Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes, liver, prostate and skeletal muscle for isoform 2
genes like me logo Genes that share expressions with NUB1: view

Orthologs for NUB1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NUB1 36
  • 99.27 (n)
  • 99.37 (a)
NUB1 37
  • 100 (a)
(Bos Taurus)
Mammalia NUB1 36
  • 85.94 (n)
  • 86.97 (a)
NUB1 37
  • 87 (a)
(Canis familiaris)
Mammalia NUB1 36
  • 89.03 (n)
  • 92.83 (a)
NUB1 37
  • 92 (a)
(Mus musculus)
Mammalia Nub1 36
  • 82.76 (n)
  • 86.95 (a)
Nub1 16
Nub1 37
  • 87 (a)
(Monodelphis domestica)
Mammalia NUB1 37
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia NUB1 37
  • 75 (a)
(Rattus norvegicus)
Mammalia Nub1 36
  • 82.33 (n)
  • 87.6 (a)
(Gallus gallus)
Aves NUB1 36
  • 67.11 (n)
  • 65.89 (a)
NUB1 37
  • 64 (a)
(Anolis carolinensis)
Reptilia NUB1 37
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nub1 36
  • 61.76 (n)
  • 59.2 (a)
(Danio rerio)
Actinopterygii nub1 36
  • 52.36 (n)
  • 42.73 (a)
nub1 37
  • 42 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011519 36
  • 42.41 (n)
  • 31.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15445 36
  • 43.8 (n)
  • 31.22 (a)
CG15445 37
  • 28 (a)
CG5111 37
  • 27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G12550 36
  • 41.74 (n)
  • 27.29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
Species with no ortholog for NUB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUB1 Gene

Gene Tree for NUB1 (if available)
Gene Tree for NUB1 (if available)

Paralogs for NUB1 Gene

No data available for Paralogs for NUB1 Gene

Variants for NUB1 Gene

Sequence variations from dbSNP and Humsavar for NUB1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6747 -- 151,378,222(+) GGACC(A/G)CAGCA utr-variant-3-prime
rs14684 -- 151,378,278(-) AAGGG(A/G)GGGAA utr-variant-3-prime
rs365741 -- 151,345,691(-) TGATG(A/G)TATTA intron-variant
rs367357 -- 151,351,916(+) GTAAA(A/T)cacac intron-variant
rs367547 -- 151,353,072(-) ATAGA(A/G)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUB1 Gene

Variant ID Type Subtype PubMed ID
nsv509225 CNV Insertion 20534489
esv2735398 CNV Deletion 23290073
esv2735399 CNV Deletion 23290073
esv4189 CNV Deletion 18987735
esv2735400 CNV Deletion 23290073
esv2674263 CNV Deletion 23128226
esv1609162 CNV Deletion 17803354
nsv889489 CNV Loss 21882294

Relevant External Links for NUB1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for NUB1 Gene

(1) University of Copenhagen DISEASES for NUB1 Gene

(1) Novoseek inferred disease relationships for NUB1 Gene

Disease -log(P) Hits PubMed IDs
lebers congenital amaurosis 90.2 2
genes like me logo Genes that share disorders with NUB1: view

No data available for UniProtKB/Swiss-Prot for NUB1 Gene

Publications for NUB1 Gene

  1. NUB1, a NEDD8-interacting protein, is induced by interferon and down- regulates the NEDD8 expression. (PMID: 11259415) Kito K. … Kamitani T. (J. Biol. Chem. 2001) 2 3 4 23
  2. The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1. (PMID: 12374762) Akey D.T. … Sohocki M.M. (Hum. Mol. Genet. 2002) 3 4 23
  3. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PMID: 10508479) Scanlan M.J. … Old L.J. (Int. J. Cancer 1999) 2 3 4
  4. Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1. (PMID: 11585840) Kamitani T. … Yeh E.T.H. (J. Biol. Chem. 2001) 3 4
  5. Abolished interaction of NUB1 with mutant AIPL1 involved in Leber congenital amaurosis. (PMID: 15081406) Kanaya K. … Kamitani T. (Biochem. Biophys. Res. Commun. 2004) 3 23

Products for NUB1 Gene

Sources for NUB1 Gene

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