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NUB1 Gene

protein-coding   GIFtS: 58
GCID: GC07P151038

Negative Regulator Of Ubiquitin-Like Proteins 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Negative Regulator Of Ubiquitin-Like Proteins 11 2 3     BS42
NEDD8 Ultimate Buster-11 2     NUB1L2
Renal Carcinoma Antigen NY-REN-182 3     NEDD8 Ultimate Buster 12
NYREN182 3     

External Ids:    HGNC: 176231   Entrez Gene: 516672   Ensembl: ENSG000000133747   OMIM: 6079815   UniProtKB: Q9Y5A73   

Export aliases for NUB1 gene to outside databases

Previous GC identifers: GC07P150669 GC07P144850


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NUB1 Gene:
This gene encodes a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that
conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this
gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the
proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with
Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with
this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies
in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system
atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of
this gene results in multiple transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for NUB1 Gene:
NUB1 (negative regulator of ubiquitin-like proteins 1) is a protein-coding gene. Diseases associated with NUB1 include multiple system atrophy, and dementia.

UniProtKB/Swiss-Prot: NUB1_HUMAN, Q9Y5A7
Function: Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to
the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2

Gene Wiki entry for NUB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUB1 gene promoter:
         ER-alpha   STAT1   Pbx1a   Pax-5   STAT1beta   GATA-1   c-Ets-1   GATA-2   STAT1alpha   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NUB1 promoter sequence
   Search Chromatin IP Primers for NUB1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36

NUB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUB1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P151038:  view genomic region     (about GC identifiers)

Start:
151,038,785 bp from pter      End:
151,075,535 bp from pter
Size:
36,751 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 150,368,365-150,404,899     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NUB1_HUMAN, Q9Y5A7 (See protein sequence)
Recommended Name: NEDD8 ultimate buster 1  
Size: 615 amino acids; 70538 Da
Subunit: Directly interacts with NEDD8 and PSMD4/S5a, a member of the regulatory subunit of the 26S proteasome.
Isoform 1 binds to NEDD8 more efficiently than isoform 2. Interacts with AIPL1. The interaction with UBD via UBA
domains facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates UBD
degradation and that of its conjugates
Sequence caution: Sequence=AAD42865.1; Type=Frameshift; Positions=365, 393;
1 PDB 3D structure from and Proteopedia for NUB1:
1WJU (3D)    
Secondary accessions: O95422 Q75MR9 Q8IX22 Q9BXR2
Alternative splicing: 2 isoforms:  Q9Y5A7-1   Q9Y5A7-2   

Explore the universe of human proteins at neXtProt for NUB1: NX_Q9Y5A7

Explore proteomics data for NUB1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys10, Lys167, Lys312, Lys371
  • Modification sites at PhosphoSitePlus

  • See NUB1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230280.1  NP_057202.3  

    ENSEMBL proteins: 
     ENSP00000398644   ENSP00000454264   ENSP00000420638   ENSP00000418234   ENSP00000420086  
     ENSP00000420023   ENSP00000420344   ENSP00000419679   ENSP00000348110   ENSP00000457628  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR009060 UBA-like
     IPR000449 UBA/Ts_N
     IPR015940 UBA/transl_elong_EF1B_N_euk

    Graphical View of Domain Structure for InterPro Entry Q9Y5A7

    ProtoNet protein and cluster: Q9Y5A7

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: NUB1_HUMAN, Q9Y5A7
    Similarity: Contains 3 UBA domains


    NUB1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUB1_HUMAN, Q9Y5A7
    Function: Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to
    the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2
    Induction: By TNF, IFNG/IFN-gamma and IFNB1/IFN-beta

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12374762
         
    NUB1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NUB1:
     Synthetic lethal with Ras 

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target NUB1:
    hsa-mir-10a-5p (MIRT047588), hsa-mir-124-3p (MIRT022286), hsa-mir-183-5p (MIRT025004)

    Block miRNA regulation of human, mouse, rat NUB1 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NUB1:
    hsa-miR-890 hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidNUB1 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for NUB1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUB1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUB1_HUMAN, Q9Y5A7: Nucleus. Note=Predominantly nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--

    NUB1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUB1
    Interactions:

        GeneGlobe Interaction Network for NUB1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for NUB1 (Q9Y5A71, 2, 3 ENSP000003986444) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEDD8Q158432, 3, ENSP000002504954MINT-50774 MINT-50772 MINT-50773 I2D: score=1 STRING: ENSP00000250495
    UBDO152053, ENSP000003662494I2D: score=1 STRING: ENSP00000366249
    ENSG00000206468O152053I2D: score=1 
    ENSG00000228913O152053I2D: score=1 
    ENSG00000231968O152053I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process IMP16707496
    GO:0016567protein ubiquitination IMP16707496
    GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP16707496
    GO:0034341response to interferon-gamma IEP16707496
    GO:0034612response to tumor necrosis factor IEP16707496

    NUB1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUB1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUB1 gene (2 alternative transcripts): 
    NM_001243351.1  NM_016118.4  

    Unigene Cluster for NUB1:

    Negative regulator of ubiquitin-like proteins 1
    Hs.647082  [show with all ESTs]
    Unigene Representative Sequence: NM_001243351
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413040(uc022aqc.1 uc003wjw.3) ENST00000568733(uc003wjx.3)
    ENST00000468404(uc003wjy.3 uc011kvj.1) ENST00000470229 ENST00000483358
    ENST00000470316 ENST00000493588 ENST00000480907 ENST00000477666 ENST00000497987
    ENST00000460712 ENST00000480714 ENST00000355851 ENST00000566856

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate NUB1:
    hsa-miR-890 hsa-miR-2355-5p
    SwitchGear 3'UTR luciferase reporter plasmidNUB1 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NUB1
      QuantiTect SYBR Green Assays in human, mouse, rat NUB1
      QuantiFast Probe-based Assays in human, mouse, rat NUB1

    Additional mRNA sequence: 

    AF155099.1 AF300717.1 AF459743.1 AK026433.1 AK056624.1 AK127717.1 AK293159.1 AY129295.1 
    BC034716.2 BC046354.2 

    12 DOTS entries:

    DT.40223582  DT.100832633  DT.214240  DT.100819293  DT.100819291  DT.95258505  DT.97778788  DT.97826153 
    DT.95310268  DT.95107575  DT.92414583  DT.91923860 

    Selected AceView cDNA sequences (see all 285):

    CK821467 AI288254 BP345243 AI201417 AI285088 AI436765 BM967025 AL558944 
    BE466694 AI580327 AI434747 CR608975 AI222845 BU543562 AL520244 AA723820 
    BM791647 BM475611 BG754814 AL520602 AI669302 CR606629 AI318418 AA357542 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NUB1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                          -     -                                                                           
    SP2:                          -     -                             -                                             
    SP3:              -           -     -                                                                           
    SP4:                                                                                                            
    SP5:                                                                                -                           


    ECgene alternative splicing isoforms for NUB1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUB1 expression in normal human tissues (normalized intensities)      NUB1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGAGCCGGC
    NUB1 Expression
    About this image


    NUB1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
     
     Spleen (Hematopoietic System)
    NUB1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUB1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647082

    UniProtKB/Swiss-Prot: NUB1_HUMAN, Q9Y5A7
    Tissue specificity: Widely expressed with lowest expression in the pancreas for isoform 1 and in leukocytes,
    liver, prostate and skeletal muscle for isoform 2

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUB1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUB1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nub11 , 5 negative regulator of ubiquitin-like proteins 11, 5 82.76(n)1
    86.95(a)1
      5 (11.93 cM)5
    533121  NM_016736.21  NP_058016.21 
     246858155 
    chicken
    (Gallus gallus)
    Aves NUB11 negative regulator of ubiquitin-like proteins 1 67.11(n)
    65.89(a)
      420433  NM_001277495.1  NP_001264424.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUB16
    negative regulator of ubiquitin-like proteins 1
    63(a)
    1 ↔ 1
    6(3842832-3864708)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nub11 negative regulator of ubiquitin-like proteins 1 61.76(n)
    59.2(a)
      549830  NM_001017076.3  NP_001017076.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nub11 negative regulator of ubiquitin-like proteins 1 52.36(n)
    42.73(a)
      557021  XM_005170646.1  XP_005170703.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG154451 CG15445 43.8(n)
    31.22(a)
      33094  NM_167729.2  NP_728390.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G125501 AT2G12550 41.74(n)
    27.29(a)
      815729  NM_126895.3  NP_178939.2 


    ENSEMBL Gene Tree for NUB1 (if available)
    TreeFam Gene Tree for NUB1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUB1 (see all 888)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3673571,2
    C,F--144860669(+) GTAAAT/Acacac 2 -- int11Minor allele frequency- A:0.24EA 1486
    rs284837981,2
    C--144865480(+) TGTTTG/TTTTTT 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1136995341,2
    C--150390886(+) AAAAC-/AAAAAA 2 -- int11Minor allele frequency- A:0.00CSA 2
    rs113541351,2
    C--150391785(+) TTTTT-/T/TT  
            
    GGCTG
    2 -- int1 trp31NA 2
    rs580781521,2
    C--151044504(+) AAAAA-/A/AA  
            
    GTATA
    2 -- int12NA CSA 4
    rs711987091,2
    C--151045656(-) GCCTC-/AAAA  
            
    AAAAA
    2 -- int11Minor allele frequency- AAAA:0.00NA 2
    rs38387061,2
    C,F--151049004(+) CACAC-/AC/ACAC/ACACAC/ACACACAC/
    ACACACACACAC
    /ACACACACACACAC
    GTTTG
    6 -- int1 cds12NA 4
    rs591192431,2
    C--151054287(+) TTTTT-/TTTGAGAT 2 -- int11Minor allele frequency- TTT:0.00NA 2
    rs3680602891,2
    C--151058008(+) GTGAGC/TGCTGT 2 -- int10--------
    rs1154241541,2
    C,F--151058061(+) GGGGTC/TTCCCT 2 -- int11Minor allele frequency- T:0.06WA 118

    HapMap Linkage Disequilibrium report for NUB1 (151038785 - 151075535 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NUB1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1609162CNV Deletion17803354
    esv2735400CNV Deletion23290073
    esv2735399CNV Deletion23290073
    esv2735398CNV Deletion23290073
    esv4189CNV Deletion18987735
    esv2674263CNV Deletion23128226
    nsv509225CNV Insertion20534489
    nsv889489CNV Loss21882294

    Human Gene Mutation Database (HGMD): NUB1
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing NUB1
    DNA2.0 Custom Variant and Variant Library Synthesis for NUB1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607981    OMIM disorders: --

    12 diseases for NUB1:    About MalaCards
    multiple system atrophy    dementia    parkinson's disease    leber congenital amaurosis
    fanconi's anemia    blindness    renal cell carcinoma    malaria
    cerebritis    thyroiditis    prostatitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NUB1:
    Leber congenital amaurosis

    NUB1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for NUB1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lebers congenital amaurosis 90.2 3 15081406 (1), 15347646 (1)


    Export disorders for NUB1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUB1 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with NUB1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NUB1, a NEDD8-interacting protein, is induced by interferon and down- regulates the NEDD8 expression. (PubMed id 11259415)1, 2, 3, 9 Kito K.... Kamitani T. (J. Biol. Chem. 2001)
    2. Antigens recognized by autologous antibody in patients with renal- cell carcinoma. (PubMed id 10508479)1, 2, 3 Scanlan M.J....Old L.J. (Int. J. Cancer 1999)
    3. The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1. (PubMed id 12374762)1, 2, 9 Akey D.T....Sohocki M.M. (Hum. Mol. Genet. 2002)
    4. The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10. (PubMed id 16707496)1, 2 Schmidtke G.... Groettrup M. (J. Biol. Chem. 2006)
    5. NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation. (PubMed id 14757770)1, 2 Hipp M.S.... Schmidtke G. (J. Biol. Chem. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L. (PubMed id 12816948)1, 2 Tanaka T.... Kamitani T. (J. Biol. Chem. 2003)
    9. Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1. (PubMed id 11585840)1, 2 Kamitani T.... Yeh E.T.H. (J. Biol. Chem. 2001)
    10. The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments. (PubMed id 15347646)1, 9 van der Spuy J. and Cheetham M.E. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51667 HGNC: 17623 AceView: NYREN18 Ensembl:ENSG00000013374 euGenes: HUgn51667
    ECgene: NUB1 H-InvDB: NUB1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUB1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NUB1 gene:
    Search GeneIP for patents involving NUB1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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