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NUAK2 Gene

protein-coding   GIFtS: 55
GCID: GC01M205271

NUAK Family, SNF1-Like Kinase, 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NUAK Family, SNF1-Like Kinase, 21 2     EC 2.7.11.13 8
SNARK2 3 5     NUAK Family SNF1-Like Kinase 22
SNF1/AMP Activated Protein Kinase1 2     OMPHK23
Omphalocele Kinase 22 3     EC 2.7.118
SNF1/AMP Kinase-Related Kinase2 3     

External Ids:    HGNC: 295581   Entrez Gene: 817882   Ensembl: ENSG000001635457   OMIM: 6081315   UniProtKB: Q9H0933   

Export aliases for NUAK2 gene to outside databases

Previous GC identifers: GC01M202003 GC01M203537 GC01M176436


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NUAK2 Gene:
NUAK2 (NUAK family, SNF1-like kinase, 2) is a protein-coding gene. Diseases associated with NUAK2 include omphalocele, and melanoma. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is STK40.

UniProtKB/Swiss-Prot: NUAK2_HUMAN, Q9H093
Function: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by
increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects
cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated
tumor cells. Able to phosphorylate 'Ser-464' of LATS1

Gene Wiki entry for NUAK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUAK2 gene promoter:
         AhR   ER-alpha   AML1a   Arnt   c-Ets-1   HEN1   AREB6   Nkx6-1   HSF2   FOXO4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NUAK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUAK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

NUAK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUAK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205271:  view genomic region     (about GC identifiers)

Start:
205,271,187 bp from pter      End:
205,290,883 bp from pter
Size:
19,697 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUAK2_HUMAN, Q9H093 (See protein sequence)
Recommended Name: NUAK family SNF1-like kinase 2  
Size: 628 amino acids; 69612 Da
Cofactor: Magnesium

Explore the universe of human proteins at neXtProt for NUAK2: NX_Q9H093

Explore proteomics data for NUAK2 at MOPED

Post-translational modifications: 

  • Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB39. Autophosphorylated in vitro1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NUAK2 (Q9H093) (see all 18)
     FRQIVSA  IMSSLNH  VVHRDLK  RQIVSAV 


    See NUAK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112214.1  
    ENSEMBL proteins: 
     ENSP00000356125  

    NUAK2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: NUAK family, SNF1-like kinase, 2
    NuaK subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9H093

    ProtoNet protein and cluster: Q9H093

    UniProtKB/Swiss-Prot: NUAK2_HUMAN, Q9H093
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 protein kinase domain


    NUAK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUAK2_HUMAN, Q9H093
    Function: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by
    increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects
    cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated
    tumor cells. Able to phosphorylate 'Ser-464' of LATS1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-208

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14976552
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14976552
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI19927127
         
    NUAK2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NUAK2:
     Decreased Hepatitis C virus re 

         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nuak2):
     craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  mortality/aging  nervous system  no phenotypic analysis  pigmentation 
     tumorigenesis  vision/eye 

    NUAK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Nuak2tm1Esu for NUAK2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NUAK2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NUAK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NUAK2

    miRNA
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    miRTarBase miRNAs that target NUAK2:
    hsa-mir-98-5p (MIRT027532)

    Block miRNA regulation of human, mouse, rat NUAK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUAK2 (see all 18):
    hsa-miR-498 hsa-miR-29b-1* hsa-miR-570 hsa-miR-1297 hsa-miR-23a hsa-miR-296-5p hsa-miR-548c-3p hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmidNUAK2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NUAK2

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    Sino Biological Human cDNA Clone for NUAK2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    mitochondrion1
    plasma membrane1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----

    NUAK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUAK2 About    
    See pathways by source

    SuperPathContained pathways About
    1Glucose / Energy Metabolism
    Glucose / Energy Metabolism
    2Cytoskeletal Signaling
    Cytoskeletal Signaling
    3Apoptosis and Autophagy
    Apoptosis and Autophagy

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for NUAK2
        Apoptosis and Autophagy
    Cytoskeletal Signaling
    Glucose / Energy Metabolism




    NUAK2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUAK2
    Interactions:

        Search GeneGlobe Interaction Network for NUAK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for NUAK2 (Q9H0933 ENSP000003561254) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    SMAD2Q157963, ENSP000002621604I2D: score=3 STRING: ENSP00000262160
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CDC37Q165433, ENSP000002220054I2D: score=1 STRING: ENSP00000222005
    HSP90AA1P079003, ENSP000003351534I2D: score=1 STRING: ENSP00000335153
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA14976552
    GO:0006915apoptotic process IEA--
    GO:0009103lipopolysaccharide biosynthetic process ----
    GO:0030036actin cytoskeleton organization IDA14575707
    GO:0042149cellular response to glucose starvation IDA14575707

    NUAK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NUAK2

    3 HMDB Compounds for NUAK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NUAK2 gene: 
    NM_030952.1  

    Unigene Cluster for NUAK2:

    NUAK family, SNF1-like kinase, 2
    Hs.497512  [show with all ESTs]
    Unigene Representative Sequence: CR749209
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367157(uc009xbj.1 uc001hce.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate NUAK2 (see all 18):
    hsa-miR-498 hsa-miR-29b-1* hsa-miR-570 hsa-miR-1297 hsa-miR-23a hsa-miR-296-5p hsa-miR-548c-3p hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmidNUAK2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NUAK2
      QuantiFast Probe-based Assays in human, mouse, rat NUAK2

    Additional mRNA sequence: 

    AK074830.1 AK303577.1 AK309520.1 AL136891.1 BC017306.2 BX537564.1 CR749209.1 

    4 DOTS entries:

    DT.95158344  DT.102830485  DT.92025857  DT.97806362 

    Selected AceView cDNA sequences (see all 79):

    AW134994 BQ064231 BQ056490 BC017306 AL136891 BQ065997 AA227872 BM909401 
    CO247869 AA627217 BQ060729 AI302354 BQ065633 BQ882468 BQ055919 BQ057240 
    BQ056806 NM_030952 BX537564 CR749209 BQ062868 AL710447 CA487493 BG753131 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NUAK2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                    -     -                                                   


    ECgene alternative splicing isoforms for NUAK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUAK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NUAK2 Expression
    About this image


    NUAK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Skeletal Muscle (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Somite (Muscoskeletal System)
             Muscle Progenitor Cells Thoracic Ventrolateral Dermomyotome Lip
     
     Lymph (Hematopoietic System)
    NUAK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUAK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.497512
        Custom PCR Arrays for NUAK2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUAK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUAK2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nuak21 , 5 NUAK family, SNF1-like kinase, 21, 5 84.78(n)1
    87.18(a)1
      1 (57.24 cM)5
    741371  NM_001195025.11  NP_001181954.11 
     1323161265 
    chicken
    (Gallus gallus)
    Aves NUAK21 NUAK family, SNF1-like kinase, 2 70.24(n)
    68.84(a)
      419828  XM_004934929.1  XP_004934986.1 
    lizard
    (Anolis carolinensis)
    Reptilia NUAK26
    NUAK family, SNF1-like kinase, 2
    62(a)
    1 ↔ 1
    4(115983297-116003834)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.83152 Xenopus laevis transcribed sequence with moderate similarity more 74.95(n)    BX845529.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nuak21 NUAK family, SNF1-like kinase, 2 64.28(n)
    65.32(a)
      560275  XM_683672.6  XP_688764.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG431436
    --
    11(a)
    1 → many
    3R(6090028-6133204)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-826
    Protein UNC-82, isoform e
    14(a)
    1 → many
    IV(7424496-7444662) WBGene00006814
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNF16
    AMP-activated serine/threonine protein kinase foun...
    23(a)
    1 → many
    IV(1412373-1414274) YDR477W
    barley
    (Hordeum vulgare)
    Liliopsida Hv.4642 Transcribed sequence with weak similarity to protein more 71.01(n)    AL504913.1 


    ENSEMBL Gene Tree for NUAK2 (if available)
    TreeFam Gene Tree for NUAK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUAK2 gene
    STK402  TRIB32  NUAK12  PRKAA22  HUNK2  TRIB12  PRKAA12  TRIB22  
    MELK2  
    10 SIMAP similar genes for NUAK2 using alignment to 1 protein entry:     NUAK2_HUMAN:
    DKFZp686F01113    NUAK1    MARK3    MARK1    TSSK3    PIM3
    PRKAA2    Par1b    MARK2    NEK7

    NUAK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUAK2 (see all 535)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0409684
    A breast pleomorphic lobular carcinoma sample4--see VAR_0409682 G E mis40--------
    VAR_0409664
    An ovarian Endometrioid carcinoma sample4--see VAR_0409662 K R mis40--------
    rs2015708531,2
    C--211808796(+) TCTGC-/AAGGGG 1 -- int10--------
    rs1832286281,2
    --211808825(+) CGGTGC/GGGGTG 1 -- int10--------
    rs1875503221,2
    --211808896(+) AGCTGC/TCCAGC 1 -- int10--------
    rs121236471,2
    C,F,H--211808915(+) AAAGGG/AGATTT 1 -- int110Minor allele frequency- A:0.06NS EA NA 962
    rs1909286901,2
    --211808951(+) TGGGGC/GTGTCT 1 -- int10--------
    rs1827653791,2
    --211808961(+) TTTACA/GCAGCA 1 -- int10--------
    rs1168064851,2
    C--211809076(+) AGGCCA/GGAAGA 1 -- int10--------
    rs1150057771,2
    C--211809082(+) GAAGAC/GCAACT 1 -- int10--------

    HapMap Linkage Disequilibrium report for NUAK2 (205271187 - 205290883 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NUAK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832381CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUAK2
    DNA2.0 Custom Variant and Variant Library Synthesis for NUAK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608131    OMIM disorders: --

    4 diseases for NUAK2:    
    About MalaCards
    omphalocele    melanoma    cervicitis    endotheliitis


    NUAK2 for disorders           About GeneDecksing


    Export disorders for NUAK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUAK2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with NUAK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. (PubMed id 14575707)1, 2, 9 Suzuki A.... Esumi H. (Biochem. Biophys. Res. Commun. 2003)
    3. Identification of SNF1/AMP kinase-related kinase as an NF-kappaB- regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness. (PubMed id 15345718)1, 2, 9 Legembre P.... Peter M.E. (J. Biol. Chem. 2004)
    4. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. (PubMed id 19927127)1, 2 Humbert N....Bernard D. (EMBO J. 2010)
    5. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (EMBO J. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. (PubMed id 11284715)1, 9 Lefebvre D.L....Rosen C.F. (Biochem. J. 2001)
    9. Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes. (PubMed id 19652946)1, 9 Rune A....Zierath J.R. (Diabetologia 2009)
    10. Identification of a novel substrate for TNFalpha-induced kinase NUAK2. (PubMed id 18023418)1, 9 Yamamoto H....Kitakaze M. (Biochem. Biophys. Res. Commun. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81788 HGNC: 29558 AceView: SNARK Ensembl:ENSG00000163545 euGenes: HUgn81788
    ECgene: NUAK2 H-InvDB: NUAK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NUAK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NUAK2 gene:
    Search GeneIP for patents involving NUAK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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