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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUAK2 Gene

protein-coding   GIFtS: 53
GCID: GC01M205271

NUAK family, SNF1-like kinase, 2
 Explore 2 diseases affiliated with
NUAK2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NUAK2    

Aliases
for NUAK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NUAK Family, SNF1-Like Kinase, 21 2     FLJ903491
SNARK1 2 3     NUAK Family SNF1-Like Kinase 22
Omphalocele Kinase 22 3     SNF1/AMP Activated Protein Kinase2
SNF1/AMP Kinase-Related Kinase2 3     OMPHK23
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 295581   Entrez Gene: 817882   Ensembl: ENSG000001635457   OMIM: 6081315   UniProtKB: Q9H0933   

Export aliases for NUAK2 gene to outside databases

Previous GC identifers: GC01M202003 GC01M203537 GC01M176436


Summaries
for NUAK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NUAK2_HUMAN, Q9H093
Function: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by
increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells
from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor
cells. Able to phosphorylate 'Ser-464' of LATS1

Gene Wiki entry for NUAK2


Genomic Views
for NUAK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUAK2 gene promoter:
         AhR   ER-alpha   AML1a   Arnt   c-Ets-1   HEN1   AREB6   Nkx6-1   HSF2   FOXO4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NUAK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUAK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

NUAK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUAK2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M205271:  view genomic region     (about GC identifiers)

Start:
 205,271,187 bp from pter      End:
 205,290,883 bp from pter
Size:
 19,697 bases      Orientation:
 minus strand

Proteins
for NUAK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NUAK2_HUMAN, Q9H093 (See protein sequence)
Recommended Name: NUAK family SNF1-like kinase 2  
Size: 628 amino acids; 69612 Da
Cofactor: Magnesium

Explore the universe of human proteins at neXtProt for NUAK2: NX_Q9H093

Post-translational modifications:

  • Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
    • Autophosphorylated in vitro1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H093

    • 4/18 DME Specific Peptides for NUAK2 (Q9H093) (see all 18)
     FRQIVSA  IMSSLNH  VVHRDLK  RQIVSAV 

    NUAK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_112214.1  
    ENSEMBL proteins: 
     ENSP00000356125  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant NUAK2 Protein
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    Uscn Proteins for NUAK2


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    Uscn ELISAs and CLIAs for NUAK2

    Protein Domains /
    Families
    for NUAK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NUAK2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9H093

    ProtoNet protein and cluster: Q9H093

    UniProtKB/Swiss-Prot: NUAK2_HUMAN, Q9H093
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for NUAK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NUAK2_HUMAN, Q9H093
    Function: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by
    increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells
    from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor
    cells. Able to phosphorylate 'Ser-464' of LATS1
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-208

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUAK2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate NUAK2 (see all 18):
    hsa-miR-498 hsa-miR-29b-1* hsa-miR-570 hsa-miR-1297 hsa-miR-23a hsa-miR-296-5p hsa-miR-548c-3p hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmid: NUAK2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUAK2 (see all 6)
    OriGene siRNA: NUAK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUAK2

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NUAK2 

    Cell Line
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    Search LifeMap BioReagents cell lines for NUAK2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUAK2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14976552
    GO:0004674protein serine/threonine kinase activity IDA19927127
    GO:0005515protein binding IPI19927127
    GO:0005524ATP binding IDA14976552


    NUAK2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NUAK2:
     Decreased Hepatitis C virus re 

    Animal Models:
         Mouse knock-out Nuak2tm1Esu for NUAK2
         12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nuak2):
     craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size 
     homeostasis/metabolism  mortality/aging  nervous system  no phenotypic analysis  pigmentation 
     tumorigenesis  vision/eye 

    NUAK2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NUAK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00
    2Apoptosis and Autophagy
    		Apoptosis and Autophagy1.00
    3Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for NUAK2
        Apoptosis and Autophagy
    Cytoskeletal Signaling
    Glucose / Energy Metabolism



    NUAK2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUAK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/14 Interacting proteins for NUAK2 (Q9H0933 ENSP000003561254) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACVR1Q047713, ENSP000002636404I2D: score=3 STRING: ENSP00000263640
    SMAD2Q157963, ENSP000002621604I2D: score=3 STRING: ENSP00000262160
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    CDC37Q165433, ENSP000002220054I2D: score=1 STRING: ENSP00000222005
    HSP90AA1P079003, ENSP000003351534I2D: score=1 STRING: ENSP00000335153
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA14976552
    GO:0006915apoptotic process IEA--
    GO:0030036actin cytoskeleton organization IDA14575707
    GO:0042149cellular response to glucose starvation IDA14575707
    GO:0043066negative regulation of apoptotic process IDA15345718


    NUAK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NUAK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NUAK2

    3 HMDB Compounds for NUAK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about NUAK2 

    Transcripts
    for NUAK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NUAK2 gene: 
    NM_030952.1  

    Unigene Cluster for NUAK2:

    NUAK family, SNF1-like kinase, 2
    Hs.497512  [show with all ESTs]
    Unigene Representative Sequence: CR749209
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367157(uc009xbj.1 uc001hce.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUAK2
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate NUAK2 (see all 18):
    hsa-miR-498 hsa-miR-29b-1* hsa-miR-570 hsa-miR-1297 hsa-miR-23a hsa-miR-296-5p hsa-miR-548c-3p hsa-miR-26b
    SwitchGear 3'UTR luciferase reporter plasmid: NUAK2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NUAK2 (see all 6)
    OriGene siRNA: NUAK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NUAK2
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NUAK2
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    Additional cDNA sequence: 

    AK074830.1 AK303577.1 AK309520.1 AL136891.1 BC017306.2 BX537564.1 CR749209.1 

    4 DOTS entries:

    DT.95158344  DT.102830485  DT.92025857  DT.97806362 

    24/79 AceView cDNA sequences (see all 79):

    AA227872 BQ060729 BM909401 NM_030952 BQ065997 BQ882468 CO247869 BQ064231 
    BQ057240 BQ056806 BQ065633 BQ056490 AL136891 AW134994 AI302354 BC017306 
    AA627217 BQ055919 BE747923 BP350165 AL710447 CD632909 CD101707 BQ059508 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NUAK2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:                                                                              
    SP2:                                                                              
    SP3:                                                                              
    SP4:                    -     -                                                   


    ECgene alternative splicing isoforms for NUAK2

    Expression
    for NUAK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUAK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NUAK2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See NUAK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUAK2

    SOURCE GeneReport for Unigene cluster: Hs.497512
        SABiosciences Custom PCR Arrays for NUAK2
    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for NUAK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NUAK2 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NUAK21 NUAK family, SNF1-like kinase, 2 70.22(n)
    68.87(a)    		   419828  XM_417962.3  XP_417962.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NUAK26
    		 --
    		 62(a)
    		 1 ↔ 1
    		 4(115983519-116001811)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.83152 Xenopus laevis transcribed sequence with moderate similarity more 74.95(n)    BX845529.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii nuak21 NUAK family, SNF1-like kinase, 2 64.46(n)
    65.32(a)    		   560275  XM_683672.5  XP_688764.3 
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-826
    		 UNCoordinated family member (unc-82)
    		 13(a)
    		 1 → many
    		 IV(7424485-7444651)
    barley
    (Hordeum vulgare)    		 Liliopsida Hv.4642 Transcribed sequence with weak similarity to protein more 71.01(n)    AL504913.1 


    ENSEMBL Gene Tree for NUAK2 (if available)
    TreeFam Gene Tree for NUAK2 (if available) 

    Paralogs
    for NUAK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUAK2 gene
    BRSK12  NUAK12  MARK12  BRSK22  SIK32  SNRK2  SIK22  MARK22  
    NIM12  SIK12  MARK42  MARK32  
    11 SIMAP similar genes for NUAK2 using alignment to 1 protein entry:     NUAK2_HUMAN:
    DKFZp686F01113    NUAK1    MARK3    MARK1    TSSK3    PIM3
    PRKAA2    Par1b    MARK2    NEK7    MARK4

    NUAK2 for paralogs           About GeneDecksing



    Genomic Variants
    for NUAK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/418 NCBI SNPs in NUAK2 are shown (see all 418)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2015708531,2
    		--205270696(+) TCTGC-/AAGGGG 1 -- int10--------
    rs1832286281,2
    		--205270725(+) CGGTGC/GGGGTG 1 -- int10--------
    rs1875503221,2
    		--205270796(+) AGCTGC/TCCAGC 1 -- int10--------
    rs121236471,2
    		C,F,H,--205270815(+) AAAGGG/AGATTT 1 -- int110Minor allele frequency- A:0.06NS EA NA 962
    rs1909286901,2
    		--205270851(+) TGGGGC/GTGTCT 1 -- int10--------
    rs1827653791,2
    		--205270861(+) TTTACA/GCAGCA 1 -- int10--------
    rs1168064851,2
    		C,--205270976(+) AGGCCA/GGAAGA 1 -- int10--------
    rs1150057771,2
    		C,--205270982(+) GAAGAC/GCAACT 1 -- int10--------
    rs747861621,2
    		C,F,--205271007(+) AGGGCC/TTTCCC 1 -- int12Minor allele frequency- T:0.04WA NA 238
    rs1884620001,2
    		--205271010(+) GCCTTC/TCCACC 1 -- int10--------

    HapMap Linkage Disequilibrium report for NUAK2 (205271187 - 205290883 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NUAK2: --

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    Disorders / Diseases
    for NUAK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NUAK2 for disorders           About GeneDecksing

    OMIM gene information: 608131    OMIM disorders: --

    2 diseases for NUAK2:    About MalaCards
    melanoma    alcoholism


    Export disorders for NUAK2 gene to outside databases

    Publications
    for NUAK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUAK2 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with NUAK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. (PubMed id 14575707)1, 2, 9 Suzuki A.... Esumi H. (2003)
    3. Identification of SNF1/AMP kinase-related kinase as an NF-kappaB- regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness. (PubMed id 15345718)1, 2, 9 Legembre P.... Peter M.E. (2004)
    4. Regulation of ploidy and senescence by the AMPK-relat ed kinase NUAK1. (PubMed id 19927127)1, 2 Humbert N....Bernard D. (2010)
    5. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Identification and characterization of a novel sucrose-non-fermenting protein kinase/AMP-activated protein kinase-related protein kinase, SNARK. (PubMed id 11284715)1, 9 Lefebvre D.L....Rosen C.F. (2001)
    9. Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes. (PubMed id 19652946)1, 9 Rune A....Zierath J.R. (2009)
    10. Identification of a novel substrate for TNFalpha-induced kinase NUAK2. (PubMed id 18023418)1, 9 Yamamoto H....Kitakaze M. (2008)

    External Searches for NUAK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NUAK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81788 HGNC: 29558 AceView: SNARK Ensembl:ENSG00000163545 euGenes: HUgn81788
    ECgene: NUAK2 H-InvDB: NUAK2

    Other Databases showing NUAK2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NUAK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUAK2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NUAK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NUAK2 gene:
    Search GeneIP for patents involving NUAK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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