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Aliases for NUAK2 Gene

Aliases for NUAK2 Gene

  • NUAK Family, SNF1-Like Kinase, 2 2 3
  • SNF1/AMP Activated Protein Kinase 2 3
  • SNF1/AMP Kinase-Related Kinase 3 4
  • Omphalocele Kinase 2 3 4
  • EC 2.7.11.1 4 63
  • SNARK 3 4
  • EC 2.7.11 63
  • OMPHK2 4

External Ids for NUAK2 Gene

Previous GeneCards Identifiers for NUAK2 Gene

  • GC01M202003
  • GC01M203537
  • GC01M205271
  • GC01M176436

Summaries for NUAK2 Gene

GeneCards Summary for NUAK2 Gene

NUAK2 (NUAK Family, SNF1-Like Kinase, 2) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Glucose / Energy Metabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is NUAK1.

UniProtKB/Swiss-Prot for NUAK2 Gene

  • Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate Ser-464 of LATS1.

Gene Wiki entry for NUAK2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUAK2 Gene

Genomics for NUAK2 Gene

Regulatory Elements for NUAK2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NUAK2 Gene

Chromosome:
1
Start:
205,302,059 bp from pter
End:
205,321,791 bp from pter
Size:
19,733 bases
Orientation:
Minus strand

Genomic View for NUAK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUAK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUAK2 Gene

Proteins for NUAK2 Gene

  • Protein details for NUAK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H093-NUAK2_HUMAN
    Recommended name:
    NUAK family SNF1-like kinase 2
    Protein Accession:
    Q9H093

    Protein attributes for NUAK2 Gene

    Size:
    628 amino acids
    Molecular mass:
    69612 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NUAK2 Gene

Proteomics data for NUAK2 Gene at MOPED

Post-translational modifications for NUAK2 Gene

  • Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylated in vitro.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NUAK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NUAK2 (NuaK2)

Domains & Families for NUAK2 Gene

Gene Families for NUAK2 Gene

Suggested Antigen Peptide Sequences for NUAK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H093

UniProtKB/Swiss-Prot:

NUAK2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.
genes like me logo Genes that share domains with NUAK2: view

Function for NUAK2 Gene

Molecular function for NUAK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation on Thr-208.
UniProtKB/Swiss-Prot Function:
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate Ser-464 of LATS1.

Enzyme Numbers (IUBMB) for NUAK2 Gene

Gene Ontology (GO) - Molecular Function for NUAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14976552
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 14976552
GO:0005515 protein binding IPI 19927127
GO:0005524 ATP binding IDA 14976552
genes like me logo Genes that share ontologies with NUAK2: view
genes like me logo Genes that share phenotypes with NUAK2: view

Animal Models for NUAK2 Gene

MGI Knock Outs for NUAK2:

Animal Model Products

No data available for Transcription Factor Targets and HOMER Transcription for NUAK2 Gene

Localization for NUAK2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUAK2 Gene COMPARTMENTS Subcellular localization image for NUAK2 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for NUAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0031588 AMP-activated protein kinase complex IBA --
genes like me logo Genes that share ontologies with NUAK2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NUAK2 Gene

Pathways & Interactions for NUAK2 Gene

genes like me logo Genes that share pathways with NUAK2: view

Pathways by source for NUAK2 Gene

3 Cell Signaling Technology pathways for NUAK2 Gene

SIGNOR curated interactions for NUAK2 Gene

Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for NUAK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 14976552
GO:0006915 apoptotic process IEA --
GO:0030036 actin cytoskeleton organization IDA 14575707
GO:0032007 negative regulation of TOR signaling IBA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with NUAK2: view

Drugs & Compounds for NUAK2 Gene

(3) Drugs for NUAK2 Gene - From: HMDB and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
WZ4003 Pharma 0
Magnesium Nutra 0

(1) Additional Compounds for NUAK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with NUAK2: view

Transcripts for NUAK2 Gene

mRNA/cDNA for NUAK2 Gene

Unigene Clusters for NUAK2 Gene

NUAK family, SNF1-like kinase, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUAK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1:
SP2:
SP3:
SP4: - -

Relevant External Links for NUAK2 Gene

GeneLoc Exon Structure for
NUAK2
ECgene alternative splicing isoforms for
NUAK2

Expression for NUAK2 Gene

mRNA expression in normal human tissues for NUAK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NUAK2 Gene

This gene is overexpressed in Whole Blood (x9.6), Esophagus - Mucosa (x5.9), Vagina (x5.2), and Cervix - Ectocervix (x4.3).

Protein differential expression in normal tissues from HIPED for NUAK2 Gene

This gene is overexpressed in Heart (66.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NUAK2 Gene



SOURCE GeneReport for Unigene cluster for NUAK2 Gene Hs.497512

genes like me logo Genes that share expression patterns with NUAK2: view

Protein tissue co-expression partners for NUAK2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NUAK2 Gene

Orthologs for NUAK2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NUAK2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NUAK2 35
  • 87.69 (n)
  • 87.91 (a)
NUAK2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nuak2 35
  • 84.78 (n)
  • 87.18 (a)
Nuak2 16
Nuak2 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NUAK2 35
  • 98.83 (n)
  • 98.25 (a)
NUAK2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nuak2 35
  • 84.32 (n)
  • 86.52 (a)
cow
(Bos Taurus)
Mammalia NUAK2 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUAK2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUAK2 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves NUAK2 35
  • 70.24 (n)
  • 68.84 (a)
NUAK2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUAK2 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nuak2 35
  • 62.16 (n)
  • 63.23 (a)
Str.4072 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8315 35
zebrafish
(Danio rerio)
Actinopterygii nuak2 35
  • 64.28 (n)
  • 65.32 (a)
nuak2 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG43143 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-82 36
  • 14 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNF1 36
  • 23 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.464 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 56 (a)
OneToMany
Species with no ortholog for NUAK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NUAK2 Gene

ENSEMBL:
Gene Tree for NUAK2 (if available)
TreeFam:
Gene Tree for NUAK2 (if available)

Paralogs for NUAK2 Gene

Paralogs for NUAK2 Gene

(10) SIMAP similar genes for NUAK2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NUAK2: view

Variants for NUAK2 Gene

Sequence variations from dbSNP and Humsavar for NUAK2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1105231 -- 205,310,691(-) tgtgt(A/G)tatat intron-variant
rs1106201 -- 205,303,798(+) AGCTC(C/G/T)AAGGC synonymous-codon, missense, reference
rs1106202 -- 205,303,855(+) AGGAG(C/G)AGCCC synonymous-codon, reference
rs1110303 -- 205,306,844(+) ACCTC(A/G)TGATA intron-variant, upstream-variant-2KB
rs1110304 -- 205,306,897(+) ACCAC(A/G)TAAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NUAK2 Gene

Variant ID Type Subtype PubMed ID
nsv832381 CNV Gain 17160897

Variation tolerance for NUAK2 Gene

Residual Variation Intolerance Score: 35.87% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.41; 71.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NUAK2 Gene

HapMap Linkage Disequilibrium report
NUAK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NUAK2 Gene

Disorders for NUAK2 Gene

Relevant External Links for NUAK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NUAK2
genes like me logo Genes that share disorders with NUAK2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NUAK2 Gene

Publications for NUAK2 Gene

  1. Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes. (PMID: 19652946) Rune A. … Zierath J.R. (Diabetologia 2009) 23 67
  2. Identification of a novel substrate for TNFalpha-induced kinase NUAK2. (PMID: 18023418) Yamamoto H. … Kitakaze M. (Biochem. Biophys. Res. Commun. 2008) 23 67
  3. Identification of SNF1/AMP kinase-related kinase as an NF-kappaB- regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness. (PMID: 15345718) Legembre P. … Peter M.E. (J. Biol. Chem. 2004) 23 67
  4. Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. (PMID: 14575707) Suzuki A. … Esumi H. (Biochem. Biophys. Res. Commun. 2003) 23 67
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 67

Products for NUAK2 Gene

  • Addgene plasmids for NUAK2

Sources for NUAK2 Gene

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