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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NUAK1 Gene

protein-coding   GIFtS: 61
GCID: GC12M106457

NUAK family, SNF1-like kinase, 1
 Explore 5 diseases affiliated with
NUAK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NUAK1    

Aliases
for NUAK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NUAK Family, SNF1-Like Kinase, 11 2     NuaK11
ARK51 2 3     AMP-Activated Protein Kinase Family Member 52
KIAA05371 3     NUAK Family SNF1-Like Kinase 12
Omphalocele Kinase 12 3     OMPHK13
AMPK-Related Protein Kinase 52 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 143111   Entrez Gene: 98912   Ensembl: ENSG000000745907   OMIM: 6081305   UniProtKB: O602853   

Export aliases for NUAK1 gene to outside databases

Previous GC identifers: GC12M104960 GC12M103517


Summaries
for NUAK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NUAK1_HUMAN, O60285
Function: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell
ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and
p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of
LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein
phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated
PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be
involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1
promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor
by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced
apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent
cleavage of CFLAR

Gene Wiki entry for NUAK1


Genomic Views
for NUAK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NUAK1 gene promoter:
         E2F-3a   E2F-4   E2F-5   Pax-2   CUTL1   Pax-2a   E2F-2   E2F-1   E2F   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NUAK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NUAK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NUAK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

NUAK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUAK1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M106457:  view genomic region     (about GC identifiers)

Start:
 106,457,118 bp from pter      End:
 106,533,811 bp from pter
Size:
 76,694 bases      Orientation:
 minus strand

Proteins
for NUAK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NUAK1_HUMAN, O60285 (See protein sequence)
Recommended Name: NUAK family SNF1-like kinase 1  
Size: 661 amino acids; 74305 Da
Cofactor: Magnesium
Subunit: Interact (via GILK motif) with PPP1CB; the interaction is direct and bridges NUAK1 and PPP1R12A
Subcellular location: Nucleus. Cytoplasm
Sequence caution: Sequence=BAA25463.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7MD39 Q96KA8
Alternative splicing: 2 isoforms:  O60285-1   O60285-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUAK1: NX_O60285

Post-translational modifications:

  • Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation.
    • Deubiquitinated by USP9X1
  • Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.
    • Not dephosphorylated by the myosin PP1 complex when regulating its activity, due to the presence of PPP1R12A, which
    prevents myosin PP1 from dephosphorylating NUAK1. Phosphorylated by STK38L upon stimulation with IGF11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O60285

    • 4/15 DME Specific Peptides for NUAK1 (O60285) (see all 15)
     FRQIVSA  IMSSLNH  RDLKLEN  RLSERET 

    NUAK1 Protein expression data from MOPED and PaxDb:    About this image 
    NUAK1 Protein Expression
    REFSEQ proteins: NP_055655.1  
    ENSEMBL proteins: 
     ENSP00000261402   ENSP00000446873   ENSP00000449990   ENSP00000448288  

    Human Recombinant Protein Products for NUAK1: 
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    Novus Biologicals NUAK1 Lysates
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    Uscn Proteins for NUAK1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--

    NUAK1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for NUAK1

    Protein Domains /
    Families
    for NUAK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NUAK1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O60285

    ProtoNet protein and cluster: O60285

    UniProtKB/Swiss-Prot: NUAK1_HUMAN, O60285
    Domain: The GILK motif mediates interaction with PPP1CB
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 protein kinase domain


    Function
    for NUAK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUAK1_HUMAN, O60285
    Function: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell
    ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and
    p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of
    LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein
    phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated
    PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be
    involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1
    promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor
    by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced
    apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent
    cleavage of CFLAR
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-211. Activated by phosphorylation at Ser-600 AKT1 during glucose
    starvation; the relevance of such activation in normal cells is however unsure
    Induction: Transcriptionally regulated by members of the MAF family

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI--
    GO:0004674protein serine/threonine kinase activity IDA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    NUAK1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for NUAK1:
     Decreased homologous recombina  Decreased substrate adherent c  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

         9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Nuak1):
     craniofacial  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     muscle  nervous system  pigmentation  vision/eye 

    NUAK1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NUAK1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NUAK1
    8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate NUAK1 (see all 87):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-15a hsa-miR-605 hsa-miR-374a hsa-miR-30d hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NUAK1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
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    Pathways & Interactions
    for NUAK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glucose / Energy Metabolism
    		Glucose / Energy Metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NUAK1
        Glucose / Energy Metabolism



    NUAK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NUAK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/23 Interacting proteins for NUAK1 (O602851, 2, 3 ENSP000002614024) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LATS1O958352, 3, ENSP000002533394MINT-7717790 MINT-7717777 I2D: score=1 STRING: ENSP00000253339
    USP9XQ930083, ENSP000003163574I2D: score=3 STRING: ENSP00000316357
    PRKAR1AP106443, ENSP000003514104I2D: score=2 STRING: ENSP00000351410
    S100A8P051093, ENSP000003577214I2D: score=2 STRING: ENSP00000357721
    CASP6P552123, ENSP000002651644I2D: score=1 STRING: ENSP00000265164
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006974response to DNA damage stimulus IEA--
    GO:0007155cell adhesion IEA--
    GO:0030155regulation of cell adhesion IDA--
    GO:0035507regulation of myosin-light-chain-phosphatase activity IDA--
    GO:0042127regulation of cell proliferation TAS--

    NUAK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NUAK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NUAK1

    3 HMDB Compounds for NUAK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--
    Search CenterWatch for drugs/clinical trials and news about NUAK1 

    Transcripts
    for NUAK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NUAK1 gene: 
    NM_014840.2  

    Unigene Cluster for NUAK1:

    NUAK family, SNF1-like kinase, 1
    Hs.524692  [show with all ESTs]
    Unigene Representative Sequence: BC152462
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261402(uc001tlj.1) ENST00000553094 ENST00000549704 ENST00000548902


    miRNA
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    hsa-miR-576-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-15a hsa-miR-605 hsa-miR-374a hsa-miR-30d hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NUAK1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB011109.1 AK027302.1 AK289992.1 BC152462.1 

    9 DOTS entries:

    DT.97836976  DT.95262430  DT.95262431  DT.100724020  DT.216000  DT.92061181  DT.121177548  DT.91655862 
    DT.97798484 

    24/99 AceView cDNA sequences (see all 99):

    BM704220 CB052805 AA456415 AA350343 AA687911 AI671914 AW006690 NM_014840 
    AA588421 BU686994 BM990976 AA339571 AA351255 AI420620 AI128146 AA351254 
    AA148368 N64374 CA438346 AW243624 AI352421 AU125486 BQ016187 AI436157 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NUAK1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:              -           -                                             
    SP2:                          -                                             
    SP3:                                                                        
    SP4:                                      -     -     -                     


    ECgene alternative splicing isoforms for NUAK1

    Expression
    for NUAK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NUAK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTTTATGGCT
    NUAK1 Expression
    About this image

    NUAK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    EyeRetinaEye
    KidneyMetanephrosKidney
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See NUAK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NUAK1

    SOURCE GeneReport for Unigene cluster: Hs.524692

    UniProtKB/Swiss-Prot: NUAK1_HUMAN, O60285
    Tissue specificity: Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney, ovary,
    placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines

        SABiosciences Custom PCR Arrays for NUAK1
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    In Situ
    Assay Products:     
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    Orthologs
    for NUAK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NUAK1 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NUAK11 NUAK family, SNF1-like kinase, 1 77.71(n)
    83.44(a)    		   418074  XM_416310.3  XP_416310.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NUAK16
    		 --
    		 82(a)
    		 1 ↔ 1
    		 5(19036435-19094766)
    zebrafish
    (Danio rerio)    		 Actinopterygii nuak11 NUAK family, SNF1-like kinase, 1 67.07(n)
    69.59(a)    		   561496  XM_684898.1  XP_689990.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-826
    		 UNCoordinated family member (unc-82)
    		 13(a)
    		 1 → many
    		 IV(7424485-7444651)


    ENSEMBL Gene Tree for NUAK1 (if available)
    TreeFam Gene Tree for NUAK1 (if available) 

    Paralogs
    for NUAK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NUAK1 gene
    BRSK12  MARK12  BRSK22  SIK32  SNRK2  SIK22  NUAK22  MARK22  
    NIM12  SIK12  MARK42  MARK32  
    18/196 SIMAP similar genes for NUAK1 using alignment to 4 protein entries:     NUAK1_HUMAN (see all proteins) (see all similar genes):
    NUAK2    PRKAA1    BRSK2    DKFZp686F01113    MARK4    PRKAA2
    Par1b    CHEK1    MARK1    STK17A    KIAA0999    SIK1
    PHKG2    AKT2    CAMK1G    MARK2    PASK    PRKCI

    NUAK1 for paralogs           About GeneDecksing



    Genomic Variants
    for NUAK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1344 NCBI SNPs in NUAK1 are shown (see all 1344)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs796318781,2
    		--106456740(+) GTGTTA/GGCCTT 1 -- ds50010--------
    rs1174257371,2
    		--106456816(+) GAACAT/GGTAAA 1 -- ds50011Minor allele frequency- G:0.01EA 120
    rs593060161,2
    		--106456861(+) ACAATC/GAGAGA 1 -- ds50010--------
    rs72968701,2
    		C,F,A,H--106456921(+) GCAGAA/GAAGAG 1 -- ds500110Minor allele frequency- G:0.06NS EA WA NA 1208
    rs1826980691,2
    		--106457069(+) TGATTC/TTGTCA 1 -- ds50010--------
    rs72973511,2
    		C,F,H--106457242(+) TTTTTC/GCCCTG 1 -- ut31 ese3 trp312Minor allele frequency- G:0.07NS EA NA CSA WA 1486
    rs1151225461,2
    		F--106457263(+) TGGGCT/ACAAAC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs606610511,2
    		C--106457461(+) GTGGA-/TTTTTTT 1 -- ut310--------
    rs1866255761,2
    		--106457528(+) TGCCAA/GTAAAT 1 -- ut310--------
    rs1914794061,2
    		--106457646(+) TGCTCC/GCCATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NUAK1 (106457118 - 106533811 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NUAK1
         1 CNV: 71569
    Human Gene Mutation Database (HGMD): NUAK1

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    Disorders / Diseases
    for NUAK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NUAK1 for disorders           About GeneDecksing

    OMIM gene information: 608130    OMIM disorders: --

    5 diseases for NUAK1:    About MalaCards
    multiple myeloma    myeloma    colorectal cancer    hypoxia
    alcoholism

    Human Genome Epidemiology (HuGE) Navigator: NUAK1 (3 documents)

    Export disorders for NUAK1 gene to outside databases

    Publications
    for NUAK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NUAK1 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with NUAK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. (PubMed id 12409306)1, 2, 3 Suzuki A....Esumi H. (2003)
    2. ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. (PubMed id 16044163)1, 2, 9 Suzuki A....Esumi H. (2005)
    3. Regulation of caspase-6 and FLIP by the AMPK family member ARK5. (PubMed id 15273717)1, 2, 9 Suzuki A.... Esumi H. (2004)
    4. Regulation of ploidy and senescence by the AMPK-relat ed kinase NUAK1. (PubMed id 19927127)1, 2, 9 Humbert N....Bernard D. (2010)
    5. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. (PubMed id 18254724)1, 2, 9 Al-Hakim A.K....Alessi D.R. (2008)
    6. New roles for the LKB1-NUAK pathway in controlling my osin phosphatase complexes and cell adhesion. (PubMed id 20354225)1, 2, 9 ZagA^rska A....Alessi D.R. (2010)
    7. A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation. (PubMed id 21317932)1, 2 Hou X.... Sun Z.Y. (2011)
    8. NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. (PubMed id 16488889)1, 2 Suzuki A....Esumi H. (2006)
    9. ARK5 is a tumor invasion-associated factor downstream of Akt signaling. (PubMed id 15060171)1, 2 Suzuki A....Esumi H. (2004)
    10. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. (PubMed id 14976552)1, 2 Lizcano J.M....Alessi D.R. (2004)

    External Searches for NUAK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing NUAK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9891 HGNC: 14311 AceView: ARK5 Ensembl:ENSG00000074590 euGenes: HUgn9891
    ECgene: NUAK1 H-InvDB: NUAK1

    Other Databases showing NUAK1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0537

    Specialized Databases showing NUAK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NUAK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NUAK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NUAK1 gene:
    Search GeneIP for patents involving NUAK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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