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NUAK1 Gene

protein-coding   GIFtS: 62
GCID: GC12M106457

NUAK Family, SNF1-Like Kinase, 1

  See NUAK1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NUAK Family, SNF1-Like Kinase, 11 2     EC 2.7.11.13 8
ARK52 3 5     KIAA05373 5
AMP-Activated Protein Kinase Family Member 51 2     NUAK Family SNF1-Like Kinase 12
Omphalocele Kinase 12 3     OMPHK13
AMPK-Related Protein Kinase 52 3     EC 2.7.118

External Ids:    HGNC: 143111   Entrez Gene: 98912   Ensembl: ENSG000000745907   OMIM: 6081305   UniProtKB: O602853   

Export aliases for NUAK1 gene to outside databases

Previous GC identifers: GC12M104960 GC12M103517


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NUAK1 Gene:
NUAK1 (NUAK family, SNF1-like kinase, 1) is a protein-coding gene. Diseases associated with NUAK1 include omphalocele. GO annotations related to this gene include protein serine/threonine kinase activity and p53 binding. An important paralog of this gene is STK40.

UniProtKB/Swiss-Prot: NUAK1_HUMAN, O60285
Function: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell
ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and
p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of
'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the
myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1:
phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin
PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited
to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor
malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by
AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation
of the caspase and the subsequent cleavage of CFLAR

Gene Wiki entry for NUAK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the NUAK1 gene promoter:
         E2F-3a   E2F-4   E2F-5   Pax-2   CUTL1   Pax-2a   E2F-2   E2F-1   E2F   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NUAK1 promoter sequence
   Search Chromatin IP Primers for NUAK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NUAK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

NUAK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUAK1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M106457:  view genomic region     (about GC identifiers)

Start:
106,457,118 bp from pter      End:
106,533,811 bp from pter
Size:
76,694 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NUAK1_HUMAN, O60285 (See protein sequence)
Recommended Name: NUAK family SNF1-like kinase 1  
Size: 661 amino acids; 74305 Da
Cofactor: Magnesium
Subunit: Interact (via GILK motif) with PPP1CB; the interaction is direct and bridges NUAK1 and PPP1R12A
Sequence caution: Sequence=BAA25463.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7MD39 Q96KA8
Alternative splicing: 2 isoforms:  O60285-1   O60285-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NUAK1: NX_O60285

Explore proteomics data for NUAK1 at MOPED

Post-translational modifications: 

  • Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated
    phosphorylation. Deubiquitinated by USP9X1
  • Phosphorylated at Thr-211 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and
    CAB39. Not dephosphorylated by the myosin PP1 complex when regulating its activity, due to the presence of
    PPP1R12A, which prevents myosin PP1 from dephosphorylating NUAK1. Phosphorylated by STK38L upon stimulation with
    IGF11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NUAK1 (O60285) (see all 15)
     FRQIVSA  IMSSLNH  RDLKLEN  RLSERET 


    See NUAK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055655.1  
    ENSEMBL proteins: 
     ENSP00000261402   ENSP00000446873   ENSP00000449990   ENSP00000448288  

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    NUAK1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: NUAK family, SNF1-like kinase, 1
    NuaK subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O60285

    ProtoNet protein and cluster: O60285

    UniProtKB/Swiss-Prot: NUAK1_HUMAN, O60285
    Domain: The GILK motif mediates interaction with PPP1CB
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with NUAK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NUAK1_HUMAN, O60285
    Function: Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell
    ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and
    p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of
    'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the
    myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1:
    phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin
    PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited
    to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor
    malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by
    AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation
    of the caspase and the subsequent cleavage of CFLAR
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by phosphorylation on Thr-211. Activated by phosphorylation at Ser-600 AKT1 during
    glucose starvation; the relevance of such activation in normal cells is however unsure
    Induction: Transcriptionally regulated by members of the MAF family

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI--
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA19927127
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI19927127
         
    Find genes that share ontologies with NUAK1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for NUAK1:
     Decreased homologous recombina  Decreased substrate adherent c  Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nuak1):
     craniofacial  embryogenesis  growth/size/body  homeostasis/metabolism  mortality/aging 
     muscle  nervous system  pigmentation  vision/eye 

    Find genes that share phenotypes with NUAK1           About GenesLikeMe

    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target NUAK1:
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    Block miRNA regulation of human, mouse, rat NUAK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NUAK1 (see all 87):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-3607-3p hsa-miR-15a hsa-miR-605 hsa-miR-374a hsa-miR-30d hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidNUAK1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NUAK1_HUMAN, O60285: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0015630microtubule cytoskeleton IDA--
    GO:0016020membrane ----

    Find genes that share ontologies with NUAK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NUAK1 About    
    See pathways by source

    SuperPathContained pathways About
    1Glucose / Energy Metabolism
    Glucose / Energy Metabolism


    Find genes that share SuperPaths with NUAK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for NUAK1
        Glucose / Energy Metabolism


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NUAK1
    Interactions:

        GeneGlobe Interaction Network for NUAK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for NUAK1 (O602851, 2, 3 ENSP000002614024) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LATS1O958351, 2, 3, ENSP000002533394EBI-1046789,EBI-444209 MINT-7717790 MINT-7717777 I2D: score=1 STRING: ENSP00000253339
    USP9XQ930083, ENSP000003163574I2D: score=3 STRING: ENSP00000316357
    PRKAR1AP106443, ENSP000003514104I2D: score=2 STRING: ENSP00000351410
    S100A8P051093, ENSP000003577214I2D: score=2 STRING: ENSP00000357721
    CASP6P552123, ENSP000002651644I2D: score=1 STRING: ENSP00000265164
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0006974cellular response to DNA damage stimulus IEA--
    GO:0007155cell adhesion IEA--
    GO:0009103lipopolysaccharide biosynthetic process ----
    GO:0030155regulation of cell adhesion IDA--

    Find genes that share ontologies with NUAK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NUAK1

    3 HMDB Compounds for NUAK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NUAK1 gene: 
    NM_014840.2  

    Unigene Cluster for NUAK1:

    NUAK family, SNF1-like kinase, 1
    Hs.524692  [show with all ESTs]
    Unigene Representative Sequence: BC152462
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261402(uc001tlj.1) ENST00000553094 ENST00000549704 ENST00000548902

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    Additional mRNA sequence: 

    AB011109.1 AK027302.1 AK289992.1 BC152462.1 

    9 DOTS entries:

    DT.97836976  DT.95262430  DT.95262431  DT.100724020  DT.216000  DT.92061181  DT.121177548  DT.91655862 
    DT.97798484 

    Selected AceView cDNA sequences (see all 99):

    BU686994 NM_014840 AI436157 BM990976 AA351255 AU125486 AA456415 CA438346 
    AA588421 BM704220 AW243624 AI352421 BQ016187 N64374 AI342877 AI468308 
    AA609845 AA148368 AI420620 AW006690 AA339571 CB052805 AI671914 AI128146 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for NUAK1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:              -           -                                             
    SP2:                          -                                             
    SP3:                                                                        
    SP4:                                      -     -     -                     


    ECgene alternative splicing isoforms for NUAK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NUAK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTATGGCT
    NUAK1 Expression
    About this image


    NUAK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             Oligodendrocyte-like cells
     
     Kidney (Urinary System)
             Metanephros
     
     Spinal Cord (Nervous System)
             Oligodendrocyte-like cells
     
     Eye (Sensory Organs)
             Retina
     
     Neural Tube (Nervous System)
             Telencephalon
    NUAK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NUAK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524692

    UniProtKB/Swiss-Prot: NUAK1_HUMAN, O60285
    Tissue specificity: Expressed at high levels in heart and brain, and at lower levels in skeletal muscle, kidney,
    ovary, placenta, lung and liver. Highly up-regulated in colorectal cancer cell lines

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NUAK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for NUAK1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nuak11 , 5 NUAK family, SNF1-like kinase, 11, 5 87.37(n)1
    91.48(a)1
      10 (41.42 cM)5
    779761  NM_001004363.11  NP_001004363.11 
     843709055 
    chicken
    (Gallus gallus)
    Aves NUAK11 NUAK family, SNF1-like kinase, 1 77.66(n)
    83.13(a)
      418074  XM_416310.4  XP_416310.2 
    lizard
    (Anolis carolinensis)
    Reptilia NUAK16
    NUAK family, SNF1-like kinase, 1
    79(a)
    1 ↔ 1
    5(19031585-19095789)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nuak11 NUAK family, SNF1-like kinase, 1 70.58(n)
    76.51(a)
      100491029  XM_002931629.2  XP_002931675.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nuak11 NUAK family, SNF1-like kinase, 1 67.18(n)
    69.24(a)
      561496  XM_684898.2  XP_689990.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG431436
    --
    11(a)
    1 → many
    3R(6090028-6133204)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-826
    Protein UNC-82, isoform e
    14(a)
    1 → many
    IV(7424496-7444662) WBGene00006814
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNF16
    AMP-activated serine/threonine protein kinase foun...
    23(a)
    1 → many
    IV(1412373-1414274) YDR477W


    ENSEMBL Gene Tree for NUAK1 (if available)
    TreeFam Gene Tree for NUAK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NUAK1 gene
    STK402  TRIB32  PRKAA22  HUNK2  TRIB12  NUAK22  PRKAA12  TRIB22  
    MELK2  
    Selected SIMAP similar genes for NUAK1 using alignment to 4 protein entries:     NUAK1_HUMAN (see all proteins) (see all similar genes):
    NUAK2    PRKAA1    BRSK2    DKFZp686F01113    MARK4    PRKAA2
    Par1b    CHEK1    MARK1    STK17A    KIAA0999    SIK1
    PHKG2    MARK2    CAMK1G    PASK    PRKCI    PRKCZ

    Find genes that share paralogs with NUAK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NUAK1 (see all 1612)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs796318781,2
    C--106456740(+) GTGTTA/GGCCTT 1 -- ds50010--------
    rs1174257371,2
    F--106456816(+) GAACAT/GGTAAA 1 -- ds50011Minor allele frequency- G:0.01EA 120
    rs593060161,2
    C--106456861(+) ACAATC/GAGAGA 1 -- ds50010--------
    rs72968701,2
    C,F,A,H--106456921(+) GCAGAA/GAAGAG 1 -- ds500110Minor allele frequency- G:0.06NS EA WA NA 1208
    rs1826980691,2
    --106457069(+) TGATTC/TTGTCA 1 -- ds50010--------
    rs72973511,2
    C,F,H--106457242(+) TTTTTC/GCCCTG 1 -- ut31 ese3 trp312Minor allele frequency- G:0.07NS EA NA CSA WA 1486
    rs1151225461,2
    C,F--106457263(+) TGGGCT/ACAAAC 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs357193921,2
    C--106457461(+) GTGGA-/T/TT  
            
    TTTTT
    2 -- ut312NA 4
    rs1866255761,2
    --106457528(+) TGCCAA/GTAAAT 1 -- ut310--------
    rs1914794061,2
    --106457646(+) TGCTCC/GCCATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NUAK1 (106457118 - 106533811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NUAK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2746333CNV Deletion23290073
    esv25105CNV Loss19812545
    nsv832509CNV Gain17160897

    Human Gene Mutation Database (HGMD): NUAK1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NUAK1
    DNA2.0 Custom Variant and Variant Library Synthesis for NUAK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608130    OMIM disorders: --

    1 disease for NUAK1:    
    About MalaCards
    omphalocele


    Find genes that share disorders with NUAK1           About GenesLikeMe

    Genetic Association Database (GAD): NUAK1
    Human Genome Epidemiology (HuGE) Navigator: NUAK1 (3 documents)

    Export disorders for NUAK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NUAK1 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with NUAK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. (PubMed id 12409306)1, 2, 3 Suzuki A....Esumi H. (J. Biol. Chem. 2003)
    2. ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma. (PubMed id 16044163)1, 2, 9 Suzuki A.... Esumi H. (Oncogene 2005)
    3. Regulation of caspase-6 and FLIP by the AMPK family member ARK5. (PubMed id 15273717)1, 2, 9 Suzuki A.... Esumi H. (Oncogene 2004)
    4. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. (PubMed id 19927127)1, 2, 9 Humbert N....Bernard D. (EMBO J. 2010)
    5. Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains. (PubMed id 18254724)1, 2, 9 Al-Hakim A.K....Alessi D.R. (Biochem. J. 2008)
    6. New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion. (PubMed id 20354225)1, 2, 9 Zagorska A.... Alessi D.R. (Sci. Signal. 2010)
    7. A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation. (PubMed id 21317932)1, 2 Hou X.... Sun Z.Y. (Oncogene 2011)
    8. NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. (PubMed id 16488889)1, 2 Suzuki A.... Esumi H. (J. Biol. Chem. 2006)
    9. ARK5 is a tumor invasion-associated factor downstream of Akt signaling. (PubMed id 15060171)1, 2 Suzuki A.... Esumi H. (Mol. Cell. Biol. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9891 HGNC: 14311 AceView: ARK5 Ensembl:ENSG00000074590 euGenes: HUgn9891
    ECgene: NUAK1 H-InvDB: NUAK1

    (According to HUGE)
    About This Section

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    HUGE: KIAA0537

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NUAK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NUAK1 gene:
    Search GeneIP for patents involving NUAK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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