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Aliases for NTSR2 Gene

Aliases for NTSR2 Gene

  • Neurotensin Receptor 2 2 3
  • Levocabastine-Sensitive Neurotensin Receptor 3 4
  • NT-R-2 3 4
  • NTR2 3 4
  • Neurotensin Receptor, Type 2 3
  • Neurotensin Receptor Type 2 3

External Ids for NTSR2 Gene

Previous GeneCards Identifiers for NTSR2 Gene

  • GC02M011583
  • GC02M011849
  • GC02M011820
  • GC02M011748
  • GC02M011715
  • GC02M011798

Summaries for NTSR2 Gene

Entrez Gene Summary for NTSR2 Gene

  • The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTSR2 Gene

NTSR2 (Neurotensin Receptor 2) is a Protein Coding gene. Diseases associated with NTSR2 include alcohol dependence. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled neurotensin receptor activity. An important paralog of this gene is GPR39.

UniProtKB/Swiss-Prot for NTSR2 Gene

  • Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system

Tocris Summary for NTSR2 Gene

  • Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors; the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the digestive tract and hypothermic and analgesic effects. NTS1 is distributed widely throughout the brain and gastrointestinal tract, whilst NTS2 is confined to areas of the brain involved in the descending control of nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS1 and NTS2 receptors are located on chromosomes 20q13 and 2p25.1 respectively.

Gene Wiki entry for NTSR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTSR2 Gene

Genomics for NTSR2 Gene

Regulatory Elements for NTSR2 Gene

Genomic Location for NTSR2 Gene

11,658,178 bp from pter
11,670,203 bp from pter
12,026 bases
Minus strand

Genomic View for NTSR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTSR2 Gene

Proteins for NTSR2 Gene

  • Protein details for NTSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neurotensin receptor type 2
    Protein Accession:
    Secondary Accessions:
    • Q53QQ5
    • Q57Z87
    • Q8IY58
    • Q8TBH6

    Protein attributes for NTSR2 Gene

    410 amino acids
    Molecular mass:
    45385 Da
    Quaternary structure:
    No Data Available
    • Sequence=EAX00924.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for NTSR2 Gene

Proteomics data for NTSR2 Gene at MOPED

Post-translational modifications for NTSR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NTSR2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NTSR2 Gene

Domains for NTSR2 Gene

Gene Families for NTSR2 Gene

  • NTSR :GPCR / Class A : Neurotensin receptors

Suggested Antigen Peptide Sequences for NTSR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O95665
  • Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.
genes like me logo Genes that share domains with NTSR2: view

Function for NTSR2 Gene

Molecular function for NTSR2 Gene

UniProtKB/Swiss-Prot Function: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system

Gene Ontology (GO) - Molecular Function for NTSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 9851594
GO:0016492 G-protein coupled neurotensin receptor activity IEA --
genes like me logo Genes that share ontologies with NTSR2: view

Phenotypes for NTSR2 Gene

genes like me logo Genes that share phenotypes with NTSR2: view

Animal Models for NTSR2 Gene

MGI Knock Outs for NTSR2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NTSR2 Gene

Localization for NTSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTSR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for NTSR2 Gene COMPARTMENTS Subcellular localization image for NTSR2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for NTSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9851594
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NTSR2: view

Pathways for NTSR2 Gene

genes like me logo Genes that share pathways with NTSR2: view

Gene Ontology (GO) - Biological Process for NTSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 9851594
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007600 sensory perception TAS 8795617
genes like me logo Genes that share ontologies with NTSR2: view

Compounds for NTSR2 Gene

(5) Tocris Compounds for NTSR2 Gene

Compound Action Cas Number
JMV 449 Potent neurotensin receptor agonist [139026-66-7]
Neurotensin Endogenous neurotransmitter and endocrine modulator [39379-15-2]
SR 142948 Highly potent NT receptor antagonist [184162-64-9]
SR 48692 Selective nonpeptide NTS1 antagonist [146362-70-1]
Xenin 8 Neurotensin-like peptide; potentiates insulin and glucagon secretion [117442-28-1]

(1) HMDB Compounds for NTSR2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Drugbank Compounds for NTSR2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • Levocabastin
79516-68-0 target partial antagonist

(7) IUPHAR Ligand for NTSR2 Gene

Ligand Type Action Affinity Pubmed IDs
neurotensin Agonist Full agonist 8.8
JMV458 Agonist Full agonist 8.7
JMV2004 Agonist Full agonist 7.2
JMV431 Agonist Full agonist 7
levocabastine Agonist Full agonist 6.8
JMV457 Agonist Full agonist 6.8
SR48692 Agonist Full agonist 6.4

(1) Novoseek inferred chemical compound relationships for NTSR2 Gene

Compound -log(P) Hits PubMed IDs
levocabastine 79.5 2
genes like me logo Genes that share compounds with NTSR2: view

Transcripts for NTSR2 Gene

mRNA/cDNA for NTSR2 Gene

Unigene Clusters for NTSR2 Gene

Neurotensin receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTSR2 Gene

No ASD Table

Relevant External Links for NTSR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NTSR2 Gene

mRNA expression in normal human tissues for NTSR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTSR2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (8.8), Brain - Caudate (basal ganglia) (7.4), Brain - Putamen (basal ganglia) (6.9), Brain - Amygdala (6.1), and Brain - Substantia nigra (5.5).

SOURCE GeneReport for Unigene cluster for NTSR2 Gene Hs.131138

mRNA Expression by UniProt/SwissProt for NTSR2 Gene

Tissue specificity: Expressed in prostate (at protein level).
genes like me logo Genes that share expressions with NTSR2: view

No data available for Protein expression for NTSR2 Gene

Orthologs for NTSR2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NTSR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NTSR2 35
  • 99.19 (n)
  • 98.54 (a)
NTSR2 36
  • 98 (a)
(Bos Taurus)
Mammalia NTSR2 35
  • 86.58 (n)
  • 82.08 (a)
NTSR2 36
  • 78 (a)
(Canis familiaris)
Mammalia NTSR2 35
  • 86.63 (n)
  • 80.22 (a)
NTSR2 36
  • 79 (a)
(Mus musculus)
Mammalia Ntsr2 35
  • 82.22 (n)
  • 80 (a)
Ntsr2 16
Ntsr2 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Ntsr2 35
  • 82.55 (n)
  • 79.75 (a)
Species with no ortholog for NTSR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NTSR2 Gene

Gene Tree for NTSR2 (if available)
Gene Tree for NTSR2 (if available)

Paralogs for NTSR2 Gene

Paralogs for NTSR2 Gene

Selected SIMAP similar genes for NTSR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NTSR2: view

Variants for NTSR2 Gene

Sequence variations from dbSNP and Humsavar for NTSR2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs4233895 -- 11,665,619(+) CTATG(C/T)AACTC intron-variant
rs4233896 -- 11,671,727(+) caccc(A/G)cctca upstream-variant-2KB
rs4578832 -- 11,669,387(+) AACTT(A/G)CTGGG intron-variant
rs4669764 -- 11,662,760(+) tgggc(A/G)acaga intron-variant
rs4669765 -- 11,668,528(+) TAAAC(G/T)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTSR2 Gene

Variant ID Type Subtype PubMed ID
nsv469449 CNV Loss 19166990

Relevant External Links for NTSR2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTSR2 Gene

Disorders for NTSR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for NTSR2 Gene including...

Search for NTSR2 Gene in MalaCards »

Relevant External Links for NTSR2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NTSR2: view

No data available for UniProtKB/Swiss-Prot for NTSR2 Gene

Publications for NTSR2 Gene

  1. Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. (PMID: 9851594) Vita N. … Ferrara P. (Eur. J. Pharmacol. 1998) 2 3 4
  2. Molecular cloning of a levocabastine-sensitive neurotensin binding site. (PMID: 8647296) Chalon P. … Caput D. (FEBS Lett. 1996) 2 3 25
  3. Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue. (PMID: 11801734) Martin S. … Mazella J. (J. Cell. Sci. 2002) 3 23
  4. Expression of neurotensin and its receptors in pituitary adenomas. (PMID: 18624930) Giorgi R.R. … CorrA-a-Giannella M.L. (J. Neuroendocrinol. 2008) 3 23
  5. Common structural basis for constitutive activity of the ghrelin receptor family. (PMID: 15383539) Holst B. … Schwartz T.W. (J. Biol. Chem. 2004) 3 23

Products for NTSR2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NTSR2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NTSR2
    • Block miRNA regulation of NTSR2 using miScript Target Protectors

    Sources for NTSR2 Gene

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