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Aliases for NTSR2 Gene

Aliases for NTSR2 Gene

  • Neurotensin Receptor 2 2 3 5
  • Levocabastine-Sensitive Neurotensin Receptor 3 4
  • NT-R-2 3 4
  • NTR2 3 4
  • Neurotensin Receptor, Type 2 3
  • Neurotensin Receptor Type 2 3

External Ids for NTSR2 Gene

Previous GeneCards Identifiers for NTSR2 Gene

  • GC02M011583
  • GC02M011849
  • GC02M011820
  • GC02M011748
  • GC02M011715
  • GC02M011798

Summaries for NTSR2 Gene

Entrez Gene Summary for NTSR2 Gene

  • The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTSR2 Gene

NTSR2 (Neurotensin Receptor 2) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and G-protein coupled neurotensin receptor activity. An important paralog of this gene is NTSR1.

UniProtKB/Swiss-Prot for NTSR2 Gene

  • Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Tocris Summary for NTSR2 Gene

  • Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1).

Gene Wiki entry for NTSR2 Gene

Additional gene information for NTSR2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTSR2 Gene

Genomics for NTSR2 Gene

GeneHancer (GH) Regulatory Elements for NTSR2 Gene

Promoters and enhancers for NTSR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I011670 Promoter 0.9 EPDnew 550.8 0.0 -12 0.1 MXI1 ZNF3 NFYC MIER2 DMAP1 REST KLF4 SMARCB1 DNMT3B TGIF2 NTSR2 ENSG00000276411
GH02I011669 Enhancer 0.9 ENCODE 550.8 +0.2 233 0.2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF143 SP5 NFYC ZHX2 NTSR2 CDK8P1
GH02I011696 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -27.9 -27867 3.6 ELF3 FOXA2 ARID4B DMAP1 RCOR1 FOS MXD4 ELF1 KAT8 TGIF2 LPIN1 LOC101929752 ENSG00000230790 NTSR2 CDK8P1 E2F6 LOC100506405
GH02I011391 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +278.2 278206 1.6 BCOR ELF3 MXI1 SAP130 MAX ARID4B ZMYM3 SIN3A BMI1 ZNF48 LINC00570 ENSG00000231403 ROCK2 NTSR2 C2orf50 KCNF1 GC02M011344
GH02I011701 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11 -31.7 -31729 1.3 HDGF ATF1 MAX ZNF48 ATF2 POLR2A IKZF1 HMBOX1 CREB1 ATF7 LPIN1 LOC101929752 ENSG00000230790 LOC100506405 NTSR2 CDK8P1 E2F6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NTSR2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NTSR2 gene promoter:

Genomic Locations for NTSR2 Gene

Genomic Locations for NTSR2 Gene
chr2:11,658,178-11,670,203
(GRCh38/hg38)
Size:
12,026 bases
Orientation:
Minus strand
chr2:11,798,304-11,810,329
(GRCh37/hg19)

Genomic View for NTSR2 Gene

Genes around NTSR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTSR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTSR2 Gene

Proteins for NTSR2 Gene

  • Protein details for NTSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95665-NTR2_HUMAN
    Recommended name:
    Neurotensin receptor type 2
    Protein Accession:
    O95665
    Secondary Accessions:
    • Q53QQ5
    • Q57Z87
    • Q8IY58
    • Q8TBH6

    Protein attributes for NTSR2 Gene

    Size:
    410 amino acids
    Molecular mass:
    45385 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=EAX00924.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for NTSR2 Gene

Post-translational modifications for NTSR2 Gene

No Post-translational modifications

Other Protein References for NTSR2 Gene

No data available for DME Specific Peptides for NTSR2 Gene

Domains & Families for NTSR2 Gene

Gene Families for NTSR2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for NTSR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95665

UniProtKB/Swiss-Prot:

NTR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.
genes like me logo Genes that share domains with NTSR2: view

Function for NTSR2 Gene

Molecular function for NTSR2 Gene

UniProtKB/Swiss-Prot Function:
Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Gene Ontology (GO) - Molecular Function for NTSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 9851594
GO:0016492 G-protein coupled neurotensin receptor activity IEA --
genes like me logo Genes that share ontologies with NTSR2: view
genes like me logo Genes that share phenotypes with NTSR2: view

Animal Models for NTSR2 Gene

MGI Knock Outs for NTSR2:

Clone Products

  • Addgene plasmids for NTSR2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NTSR2 Gene

Localization for NTSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTSR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTSR2 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for NTSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9851594
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NTSR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NTSR2 Gene

Pathways & Interactions for NTSR2 Gene

genes like me logo Genes that share pathways with NTSR2: view

SIGNOR curated interactions for NTSR2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for NTSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway TAS 9851594
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IEA --
genes like me logo Genes that share ontologies with NTSR2: view

Drugs & Compounds for NTSR2 Gene

(13) Drugs for NTSR2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levocabastine Approved, Investigational Pharma Full agonist, Agonist, Target, partial antagonist, antagonist 4
calcium Approved Nutra 0
Neurotensin Pharma Full agonist, Agonist NTR1 activator, Endogenous neurotransmitter and endocrine modulator 0
JMV 449 Pharma Potent neurotensin receptor agonist 0
JMV2004 Pharma Full agonist, Agonist 0

(2) Additional Compounds for NTSR2 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR48692
Antagonist

(5) Tocris Compounds for NTSR2 Gene

Compound Action Cas Number
JMV 449 Potent neurotensin receptor agonist 139026-66-7
Kinetensin (human) Neurotensin-like peptide 103131-69-7
Neuromedin N (rat, mouse, porcine, canine) Neurotensin-like peptide 92169-45-4
Neurotensin Endogenous neurotransmitter and endocrine modulator 39379-15-2
Xenin 8 Neurotensin-like peptide; potentiates insulin and glucagon secretion 117442-28-1

(5) ApexBio Compounds for NTSR2 Gene

Compound Action Cas Number
JMV 449 139026-66-7
Kinetensin (human) 103131-69-7
SR 142948 184162-64-9
SR 48692 nonpeptide neurotensin antagonist 146362-70-1
Xenin 8 117442-28-1
genes like me logo Genes that share compounds with NTSR2: view

Drug Products

Transcripts for NTSR2 Gene

mRNA/cDNA for NTSR2 Gene

Unigene Clusters for NTSR2 Gene

Neurotensin receptor 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for NTSR2

Alternative Splicing Database (ASD) splice patterns (SP) for NTSR2 Gene

No ASD Table

Relevant External Links for NTSR2 Gene

GeneLoc Exon Structure for
NTSR2
ECgene alternative splicing isoforms for
NTSR2

Expression for NTSR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTSR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTSR2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.8), Brain - Caudate (basal ganglia) (x7.4), Brain - Putamen (basal ganglia) (x6.9), Brain - Amygdala (x6.1), and Brain - Substantia nigra (x5.5).

NURSA nuclear receptor signaling pathways regulating expression of NTSR2 Gene:

NTSR2

SOURCE GeneReport for Unigene cluster for NTSR2 Gene:

Hs.131138

mRNA Expression by UniProt/SwissProt for NTSR2 Gene:

O95665-NTR2_HUMAN
Tissue specificity: Expressed in prostate (at protein level).

Evidence on tissue expression from TISSUES for NTSR2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with NTSR2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTSR2 Gene

Orthologs for NTSR2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for NTSR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTSR2 33 34
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia NTSR2 33 34
  • 86.63 (n)
cow
(Bos Taurus)
Mammalia NTSR2 33 34
  • 86.58 (n)
rat
(Rattus norvegicus)
Mammalia Ntsr2 33
  • 82.55 (n)
mouse
(Mus musculus)
Mammalia Ntsr2 33 16 34
  • 82.22 (n)
Species where no ortholog for NTSR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NTSR2 Gene

ENSEMBL:
Gene Tree for NTSR2 (if available)
TreeFam:
Gene Tree for NTSR2 (if available)

Paralogs for NTSR2 Gene

Paralogs for NTSR2 Gene

(1) SIMAP similar genes for NTSR2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NTSR2: view

Variants for NTSR2 Gene

Sequence variations from dbSNP and Humsavar for NTSR2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000167119 -- 11,667,774(-) A/G intron_variant
rs1000498784 -- 11,669,048(-) A/C intron_variant
rs1000783701 -- 11,658,341(-) G/C 3_prime_UTR_variant
rs1000794305 -- 11,661,185(-) G/A intron_variant
rs1000825604 -- 11,660,965(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NTSR2 Gene

Variant ID Type Subtype PubMed ID
nsv469449 CNV loss 19166990
nsv580972 CNV loss 21841781

Variation tolerance for NTSR2 Gene

Residual Variation Intolerance Score: 84.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.98; 49.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NTSR2 Gene

Human Gene Mutation Database (HGMD)
NTSR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTSR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTSR2 Gene

Disorders for NTSR2 Gene

Additional Disease Information for NTSR2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NTSR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NTSR2 Gene

Publications for NTSR2 Gene

  1. Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. (PMID: 9851594) Vita N … Ferrara P (European journal of pharmacology 1998) 2 3 4 58
  2. Molecular cloning of a levocabastine-sensitive neurotensin binding site. (PMID: 8647296) Chalon P … Caput D (FEBS letters 1996) 2 3 25 58
  3. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick DM … Bierut L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 44 58
  4. Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors. (PMID: 19968961) Hwang JR … Seong JY (Biochemical and biophysical research communications 2010) 3 22 58
  5. Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. (PMID: 20048080) Swift SL … Maitland NJ (Cancer research 2010) 3 4 58

Products for NTSR2 Gene

  • Addgene plasmids for NTSR2

Sources for NTSR2 Gene

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