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NTSR2 Gene

protein-coding   GIFtS: 63
GCID: GC02M011798

Neurotensin Receptor 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neurotensin Receptor 21 2
Levocabastine-Sensitive Neurotensin Receptor2 3
NT-R-22 3
NTR22 3
Neurotensin Receptor Type 22
Neurotensin Receptor, Type 22

External Ids:    HGNC: 80401   Entrez Gene: 236202   Ensembl: ENSG000001690067   OMIM: 6055385   UniProtKB: O956653   

Export aliases for NTSR2 gene to outside databases

Previous GC identifers: GC02M011583 GC02M011849 GC02M011820 GC02M011748 GC02M011715 GC02M011649


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NTSR2 Gene:
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a
phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this
receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor.
However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor
antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities
suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may
exist. (provided by RefSeq, Jul 2008)

GeneCards Summary for NTSR2 Gene:
NTSR2 (neurotensin receptor 2) is a protein-coding gene. Diseases associated with NTSR2 include conduct disorder, and alveolar soft part sarcoma. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled neurotensin receptor activity. An important paralog of this gene is GHSR.

UniProtKB/Swiss-Prot: NTR2_HUMAN, O95665
Function: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a
phosphatidylinositol-calcium second messenger system

summary for NTSR2 Gene:
Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin
receptors; the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single
transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including
modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the
digestive tract and hypothermic and analgesic effects. NTS1 is distributed widely throughout the brain and
gastrointestinal tract, whilst NTS2 is confined to areas of the brain involved in the descending control of
nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS1 and NTS2
receptors are located on chromosomes 20q13 and 2p25.1 respectively.

Gene Wiki entry for NTSR2 (Neurotensin receptor 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005334.17  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NTSR2 gene promoter:
         CRE-BP1   Brachyury   ATF-2   NRSF form 1   NRSF form 2   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTSR2 promoter sequence
   Search Chromatin IP Primers for NTSR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTSR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.1   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25.1

NTSR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTSR2 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M011798:  view genomic region     (about GC identifiers)

Start:
11,798,304 bp from pter      End:
11,810,329 bp from pter
Size:
12,026 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NTR2_HUMAN, O95665 (See protein sequence)
Recommended Name: Neurotensin receptor type 2  
Size: 410 amino acids; 45385 Da
Sequence caution: Sequence=EAX00924.1; Type=Erroneous gene model prediction;
Secondary accessions: Q53QQ5 Q57Z87 Q8IY58 Q8TBH6

Explore the universe of human proteins at neXtProt for NTSR2: NX_O95665

Explore proteomics data for NTSR2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NTSR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036476.1  
    ENSEMBL proteins: 
     ENSP00000303686  
    Reactome Protein details: O95665

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NTSR: GPCR / Class A : Neurotensin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: NTS2 receptor
    Neurotensin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003986 NT2_rcpt
     IPR003984 NT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry O95665

    ProtoNet protein and cluster: O95665

    2 Blocks protein domains:
    IPB003984 Neurotensin receptor signature
    IPB003986 Neurotensin type 2 receptor signature


    UniProtKB/Swiss-Prot: NTR2_HUMAN, O95665
    Similarity: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2
    sub-subfamily


    NTSR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTR2_HUMAN, O95665
    Function: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a
    phosphatidylinositol-calcium second messenger system

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS9851594
    GO:0016492G-protein coupled neurotensin receptor activity IEA--
         
    NTSR2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NTSR2:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ntsr2):
     behavior/neurological  integument  nervous system 

    NTSR2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NTSR2: Ntsr2tm1Dafe Ntsr2tm1Hmno

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NTSR2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTSR2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NTR2_HUMAN, O95665: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9851594
    GO:0016020membrane ----
    GO:0016021integral component of membrane ----

    NTSR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NTSR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for NTSR2
        GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for NTSR2
        Peptide ligand-binding receptors
    G alpha (q) signalling events


    1 Kegg Pathway  (Kegg details for NTSR2):
        Neuroactive ligand-receptor interaction


    NTSR2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NTSR2: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NTSR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NTSR2 (O956653 ENSP000003036864) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTSP309903, ENSP000002560104I2D: score=1 STRING: ENSP00000256010
    ADRA1DENSP000003687664STRING: ENSP00000368766
    AVPR1AENSP000002991784STRING: ENSP00000299178
    AVPR1BENSP000003560944STRING: ENSP00000356094
    CCKENSP000003356574STRING: ENSP00000335657
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS9851594
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007600sensory perception TAS8795617
    GO:0042391regulation of membrane potential IEA--

    NTSR2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for NTSR2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JMV 449Potent neurotensin receptor agonist[139026-66-7]
    SR 48692Selective nonpeptide NTS1 antagonist[146362-70-1]
    SR 142948Highly potent NT receptor antagonist[184162-64-9]
    Xenin 8Neurotensin-like peptide; potentiates insulin and glucagon secretion[117442-28-1]
    NeurotensinEndogenous neurotransmitter and endocrine modulator[39379-15-2]

    1 HMDB Compound for NTSR2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for NTSR2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    LevocabastineLevocabastin (see all 3)79516-68-0targetpartial antagonist9080465 8647296 11723247

    7 IUPHAR Ligands for NTSR2 (NTS2 receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    neurotensin
    AgonistFull agonist8.811723247
    JMV458
    AgonistFull agonist8.711723247
    JMV2004
    AgonistFull agonist7.211723247
    JMV431
    AgonistFull agonist711723247
    levocabastine
    AgonistFull agonist6.811723247 8795617
    JMV457
    AgonistFull agonist6.811723247
    SR48692
    AgonistFull agonist6.411723247

    1 Novoseek inferred chemical compound relationship for NTSR2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    levocabastine 79.5 3 11304684 (1), 11723247 (1)



    NTSR2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NTSR2 gene: 
    NM_012344.3  

    Unigene Cluster for NTSR2:

    Neurotensin receptor 2
    Hs.131138  [show with all ESTs]
    Unigene Representative Sequence: NM_012344
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000306928(uc002rbq.4)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat NTSR2

    Additional mRNA sequence: 

    AY429107.1 BC022501.1 BC037776.2 Y10148.1 

    2 DOTS entries:

    DT.454934  DT.92070126 

    Selected AceView cDNA sequences (see all 25):

    CB154463 AY429107 BI758259 Y10148 BI757121 BM808829 BC037776 BM543497 
    BG714306 BX099585 AW204669 BM925480 BC022501 NM_012344 AI017154 BI597845 
    AW665722 BG707447 BG702632 BM546496 BI600170 BM172271 AV726310 AA912308 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NTSR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCGGTTAC
    NTSR2 Expression
    About this image


    NTSR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Adult Endothelial Cells Blood Brain Barrier
             caudate nucleus   
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
    NTSR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NTSR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131138

    UniProtKB/Swiss-Prot: NTR2_HUMAN, O95665
    Tissue specificity: Expressed in prostate (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NTSR2: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTSR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for NTSR2 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntsr21 , 5 neurotensin receptor 21, 5 82.22(n)1
    80(a)1
      12 (7.98 cM)5
    182171  NM_008747.21  NP_032773.21 
     166534705 


    ENSEMBL Gene Tree for NTSR2 (if available)
    TreeFam Gene Tree for NTSR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NTSR2 gene
    GHSR2  NTSR12  GPR392  NMUR12  MLNR2  NMUR22  TRHR2  
    1 SIMAP similar gene for NTSR2 using alignment to 1 protein entry:     NTR2_HUMAN:
    NTSR1

    NTSR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NTSR2 (see all 367)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs67417471,2
    C--11649342(+) CACCAT/CTGCTC 1 -- ds50013Minor allele frequency- C:0.15CSA WA EA 240
    rs1854627441,2
    --11649366(+) CTTACC/TGCCTC 1 -- ds50010--------
    rs1902216031,2
    --11649453(+) ACTCTC/TGTCCA 1 -- ds50010--------
    rs1832865471,2
    --11649466(+) ATTGCG/TCTGGC 1 -- ds50010--------
    rs731774511,2
    C,F--11649640(+) CTGGGA/GGAGAA 1 -- ds50012Minor allele frequency- G:0.09WA 120
    rs731774531,2
    C--11649669(+) CTCACG/TTGAGG 1 -- ds50012Minor allele frequency- T:0.09WA 120
    rs1414519761,2
    C--11649678(+) GGCACC/TGATTT 1 -- ds50010--------
    rs134230361,2
    C--11649749(+) TAAAAC/TTACAG 1 -- ds50011Minor allele frequency- T:0.00NA 2
    rs1882113751,2
    C--11649813(+) ACAACA/GGTAAC 1 -- ds50010--------
    rs1469978541,2
    --11649860(+) TACTAC/TGCACC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for NTSR2 (11798304 - 11810329 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NTSR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469449CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NTSR2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605538    OMIM disorders: --

    15 diseases for NTSR2:    
    About MalaCards
    conduct disorder    alveolar soft part sarcoma    cutaneous t cell lymphoma    pituitary adenoma
    alcohol dependence    adenoma    sarcoma    cerebritis
    lung cancer    squamous cell carcinoma    prostate cancer    prostatitis
    breast cancer    neuronitis    endotheliitis


    NTSR2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NTSR2
    Human Genome Epidemiology (HuGE) Navigator: NTSR2 (5 documents)

    Export disorders for NTSR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NTSR2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with NTSR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. (PubMed id 9851594)1, 2, 3 Vita N.... Ferrara P. (Eur. J. Pharmacol. 1998)
    2. Molecular cloning of a levocabastine-sensitive neurotensin binding site. (PubMed id 8647296)1, 3, 7 Chalon P....Caput D. (FEBS Lett. 1996)
    3. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1, 4 Dick D.M....Bierut L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    4. Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. (PubMed id 20048080)1, 2 Swift S.L....Maitland N.J. (Cancer Res. 2010)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2. (PubMed id 11723247)7, 9 Richard F....Kitabgi P. (Mol. Pharmacol. 2001)
    9. Common structural basis for constitutive activity of the ghrelin receptor family. (PubMed id 15383539)1, 9 Holst B....Schwartz T.W. (J. Biol. Chem. 2004)
    10. Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue. (PubMed id 11801734)1, 9 Martin S....Mazella J. (J. Cell. Sci. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23620 HGNC: 8040 AceView: NTSR2 Ensembl:ENSG00000169006 euGenes: HUgn23620
    ECgene: NTSR2 Kegg: 23620 H-InvDB: NTSR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NTSR2 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Neurotensin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NTSR2 gene:
    Search GeneIP for patents involving NTSR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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