Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTSR1 Gene

protein-coding   GIFtS: 64
GCID: GC20P061340

Neurotensin Receptor 1 (High Affinity)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neurotensin Receptor 1 (High Affinity)1 2     NTRH2 3
High-Affinity Levocabastine-Insensitive Neurotensin Receptor2 3     NTR2
NT-R-12 3     Neurotensin Receptor Type 12
NTR12 3     NTRR3

External Ids:    HGNC: 80391   Entrez Gene: 49232   Ensembl: ENSG000001011887   OMIM: 1626515   UniProtKB: P309893   

Export aliases for NTSR1 gene to outside databases

Previous GC identifers: GC20P061217 GC20P062019 GC20P062066 GC20P060810 GC20P058057


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTSR1 Gene:
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the
multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and
regulation of intestinal motility and secretion. (provided by RefSeq, Jul 2008)

GeneCards Summary for NTSR1 Gene: 
NTSR1 (neurotensin receptor 1 (high affinity)) is a protein-coding gene. Diseases associated with NTSR1 include western equine encephalitis, and pancreatic ductal carcinoma, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Peptide GPCRs. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled neurotensin receptor activity. An important paralog of this gene is GHSR.

UniProtKB/Swiss-Prot: NTR1_HUMAN, P30989
Function: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a
phosphatidylinositol-calcium second messenger system

summary for NTSR1 Gene:
Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin
receptors; the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single
transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including
modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the
digestive tract and hypothermic and analgesic effects. NTS1 is distributed widely throughout the brain and
gastrointestinal tract, whilst NTS2 is confined to areas of the brain involved in the descending control of
nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS1 and NTS2
receptors are located on chromosomes 20q13 and 2p25.1 respectively.

Gene Wiki entry for NTSR1 (Neurotensin receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011333.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NTSR1 gene promoter:
         GCNF   RelA   NF-kappaB   GATA-2   MEF-2A   POU2F1   GCNF-1   POU2F1a   aMEF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTSR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NTSR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13

NTSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTSR1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P061340:  view genomic region     (about GC identifiers)

Start:
61,340,189 bp from pter      End:
61,394,123 bp from pter
Size:
53,935 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NTR1_HUMAN, P30989 (See protein sequence)
Recommended Name: Neurotensin receptor type 1  
Size: 418 amino acids; 46259 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for NTSR1:
2LYW (3D)    
Secondary accessions: Q9H4H1 Q9H4T5

Explore the universe of human proteins at neXtProt for NTSR1: NX_P30989

Explore proteomics data for NTSR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30989

  • NTSR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NTSR1 Protein Expression
    REFSEQ proteins: NP_002522.2  
    ENSEMBL proteins: 
     ENSP00000359532  
    Reactome Protein details: P30989
    Human Recombinant Protein Products for NTSR1: 
    EMD Millipore Purified and/or Recombinant NTSR1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NTSR1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NTSR1
    GenScript Custom Purified and Recombinant Proteins Services for NTSR1
    Novus Biologicals NTSR1 Protein
    Novus Biologicals NTSR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NTSR1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9763490
    GO:0005794Golgi apparatus TAS9763490
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane IMP8381365
    GO:0016021integral to membrane ----

    NTSR1 for ontologies           About GeneDecksing



    NTSR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NTSR1
    GenScript Custom Superior Antibodies Services for NTSR1
    Novus Biologicals NTSR1 Antibodies
    Abcam antibodies for NTSR1
    Cloud-Clone Corp. Antibodies for NTSR1 
    ThermoFisher Antibody for NTSR1
    LSBio Antibodies in human, mouse, rat for NTSR1 

    Assay Products for NTSR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NTSR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NTSR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NTSR1 
    Cloud-Clone Corp. CLIAs for NTSR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NTSR: GPCR / Class A : Neurotensin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: NTS1 receptor 
    Neurotensin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003985 NT1_rcpt
     IPR003984 NT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30989

    ProtoNet protein and cluster: P30989

    2 Blocks protein domains:
    IPB003984 Neurotensin receptor signature
    IPB003985 Neurotensin type 1 receptor signature


    UniProtKB/Swiss-Prot: NTR1_HUMAN, P30989
    Similarity: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1
    sub-subfamily


    NTSR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTR1_HUMAN, P30989
    Function: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a
    phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for NTSR1:
    neurotensin receptor 1,expressed in central and peripheral nervous system,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS8381365
    GO:0005515protein binding IPI--
    GO:0016492G-protein coupled neurotensin receptor activity IMP8381365
         
    NTSR1 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ntsr1):
     adipose tissue  behavior/neurological  digestive/alimentary  growth/size  homeostasis/metabolism 
     integument  nervous system  normal 

    NTSR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NTSR1: Ntsr1tm1Hmno Ntsr1tm1Pang Ntsr1tm2Pang Ntsr1tm2Dgen

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NTSR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NTSR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTSR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTSR1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTSR1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate NTSR1:
    hsa-miR-579 hsa-miR-607 hsa-miR-2355-3p hsa-miR-885-5p hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidNTSR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NTSR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTSR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NTSR1
    Sirion Biotech Customized adenovirus for overexpression of NTSR1

    Clone
    Products:
         
    EMD Millipore Clones for the Expression of NTSR1
    OriGene clones in human, mouse for NTSR1 (see all 6)
    OriGene ORF clones in mouse, rat for NTSR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NTSR1 (NM_002531)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTSR1
    Sirion Biotech Customized lentivirus for stable overexpression of NTSR1 
                         Customized lentivirus expression plasmids for stable overexpression of NTSR1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NTSR1
    Search LifeMap BioReagents cell lines for NTSR1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTSR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NTSR1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q0.46
    Peptide GPCRs0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5GPCRs, Other
    GPCRs, Other

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NTSR1
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    3 BioSystems Pathways for NTSR1
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/8        Reactome Pathways for NTSR1 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding


    2         Kegg Pathways  (Kegg details for NTSR1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction


    NTSR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NTSR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/128 Interacting proteins for NTSR1 (P309893 ENSP000003595324) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTSP309903, ENSP000002560104I2D: score=2 STRING: ENSP00000256010
    ARRB2P321213, ENSP000002692604I2D: score=1 STRING: ENSP00000269260
    APPENSP000002849814STRING: ENSP00000284981
    CASRENSP000002961544STRING: ENSP00000296154
    CCKENSP000003356574STRING: ENSP00000335657
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS8381365
    GO:0007268synaptic transmission TAS9763490
    GO:0008344adult locomotory behavior IEA--

    NTSR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NTSR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NTSR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JMV 449Potent neurotensin receptor agonist[139026-66-7]
    SR 48692Selective nonpeptide NTS1 antagonist[146362-70-1]
    SR 142948Highly potent NT receptor antagonist[184162-64-9]
    Xenin 8Neurotensin-like peptide; potentiates insulin and glucagon secretion[117442-28-1]
    NeurotensinEndogenous neurotransmitter and endocrine modulator[39379-15-2]

    1 HMDB Compound for NTSR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    10/13 IUPHAR Ligands for NTSR1 (NTS1 receptor) (see all 13)    About this table 
    LigandTypeActionAffinityPubmed IDs
    neurotensin
    AgonistFull agonist8.3 - 9.711723247 10930533
    SR142948A
    AntagonistAntagonist8.99023294
    JMV458
    AgonistFull agonist8.811723247
    large neurotensin
    AgonistFull agonist8.711811984
    SR48692
    AntagonistAntagonist8.411723247
    KH28
    AgonistFull agonist7.9216095636
    Thr10contulakin-G
    AgonistFull agonist7.610318778
    large neuromedin N
    AgonistFull agonist7.411811984
    contulakin-G
    AgonistFull agonist610318778
    JMV457
    AgonistFull agonist5.811723247

    7 Novoseek inferred chemical compound relationships for NTSR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sr48692 89.7 6 10533985 (1), 9706144 (1), 18063561 (1), 19195889 (1)
    levocabastine 76.5 4 11304684 (1), 11723247 (1)
    dopamine 10.7 2 10196181 (1), 11890761 (1)
    thymidine 0 1 8047978 (1)
    sodium 0 4 9927610 (3)
    lipid 0 1 16406549 (1)
    calcium 0 2 9706144 (1), 14570823 (1)

    Search CenterWatch for drugs/clinical trials and news about NTSR1 / NTR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NTSR1 gene: 
    NM_002531.2  

    Unigene Cluster for NTSR1:

    Neurotensin receptor 1 (high affinity)
    Hs.590869  [show with all ESTs]
    Unigene Representative Sequence: NM_002531
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370501(uc002ydf.3) ENST00000482259
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTSR1
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate NTSR1:
    hsa-miR-579 hsa-miR-607 hsa-miR-2355-3p hsa-miR-885-5p hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidNTSR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NTSR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTSR1
    Clone
    Products:
         
    OriGene clones in human, mouse for NTSR1 (see all 6)
    OriGene ORF clones in mouse, rat for NTSR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NTSR1 (NM_002531)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTSR1
    Sirion Biotech Customized lentivirus for stable overexpression of NTSR1 
                         Customized lentivirus expression plasmids for stable overexpression of NTSR1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NTSR1
    OriGene qSTAR qPCR primer pairs in human, mouse for NTSR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NTSR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTSR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTSR1

    Additional mRNA sequence: 

    AY429106.1 BC040711.1 X70070.1 

    1 DOTS entry:

    DT.108187 

    24/29 AceView cDNA sequences (see all 29):

    BM759646 AY429106 BM738353 BE292807 BI915623 BM757252 BQ639483 BM757283 
    BX280020 BC040711 BE872844 BQ422484 NM_002531 BG469552 BM738161 X70070 
    U47726 AA157908 AA079834 AL537553 AA078742 BM738078 AA157852 AL537552 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTSR1 expression in normal human tissues (normalized intensities)      NTSR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTCCGGAG
    NTSR1 Expression
    About this image


    NTSR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 16 entries
             Thalamus
             Substantia Nigra   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Intestine
             Human Villous Mesenchymal Fibroblasts (HVMF)   
     
     Liver (Hepatobiliary System)
             Fetal Liver Stromal Cells   
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme

    See NTSR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTSR1

    SOURCE GeneReport for Unigene cluster: Hs.590869
        SABiosciences Expression via Pathway-Focused PCR Arrays including NTSR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NTSR1
    OriGene qSTAR qPCR primer pairs in human, mouse for NTSR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NTSR1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTSR1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTSR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NTSR1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntsr11 , 5 neurotensin receptor 11, 5 84.81(n)1
    86.09(a)1
      2 (103.04 cM)5
    182161  NM_018766.21  NP_061236.11 
     1804999765 
    chicken
    (Gallus gallus)
    Aves NTSR11 neurotensin receptor 1 (high affinity) 74.58(n)
    72.82(a)
      428149  NM_001245982.1  NP_001232911.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTSR16
    neurotensin receptor 1 (high affinity)
    64(a)
    1 ↔ 1
    4(152137996-152285374)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5693441 neurotensin receptor type 1-like 67.88(n)
    63.41(a)
      569344  XM_692724.4  XP_697816.4 


    ENSEMBL Gene Tree for NTSR1 (if available)
    TreeFam Gene Tree for NTSR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTSR1 gene
    GHSR2  GPR392  NMUR12  MLNR2  NMUR22  TRHR2  NTSR22  
    6 SIMAP similar genes for NTSR1 using alignment to 1 protein entry:     NTR1_HUMAN:
    NTSR2    GHSR    NMUR1    NMUR2    GPR39    MLNR

    NTSR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1529 SNPs in NTSR1 are shown (see all 1529)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs615727191,2
    --61338252(+) TTAACC/TGGTGA 1 -- us2k10--------
    rs743790891,2
    C,F--61338260(+) TGAATC/TGTGTC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1872241781,2
    --61338361(+) TCCCCA/GTGGAG 1 -- us2k10--------
    rs48092961,2
    C,F--61338388(+) CCTGCC/TCTTCA 1 -- us2k19Minor allele frequency- T:0.24NA WA CSA EA 370
    rs1916823721,2
    --61338401(+) CAGCCA/GCTATT 1 -- us2k10--------
    rs1478325461,2
    --61338429(+) TCAATC/TGAGGC 1 -- us2k10--------
    rs1838693251,2
    C--61338443(+) GAGACA/GCTAAG 1 -- us2k10--------
    rs1414136711,2
    --61338464(+) CAAATA/GTGAAG 1 -- us2k10--------
    rs1470019101,2
    --61338494(+) TCCTAC/TCTACT 1 -- us2k10--------
    rs1177736771,2
    C,F--61338544(+) CAAGAT/CTTCTA 1 -- us2k11Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for NTSR1 (61340189 - 61394123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/37 variations for NTSR1 (see all 37):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv797e199CNV Deletion23128226
    esv1917595CNV Deletion18987734
    esv2722831CNV Deletion23290073
    esv2722833CNV Deletion23290073
    esv2722828CNV Deletion23290073
    esv2645365CNV Deletion19546169
    esv2658201CNV Deletion23128226
    esv2658283CNV Deletion23128226
    esv2722832CNV Deletion23290073
    esv4782CNV Deletion18987735

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NTSR1
    DNA2.0 Custom Variant and Variant Library Synthesis for NTSR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 162651    OMIM disorders: --

    20/27 diseases for NTSR1 (see all 27):    About MalaCards
    western equine encephalitis    pancreatic ductal carcinoma    hyperglycemia    colon adenocarcinoma
    pancreatic diseases    hepatitis a    encephalitis    anorexia nervosa
    pancreatic cancer    colon cancer    hyperparathyroidism    pituitary adenoma
    schizophrenia    pancreatitis    adenocarcinoma    prostate cancer
    adenoma    glioblastoma    prostatitis    cerebritis


    NTSR1 for disorders           About GeneDecksing

    10 Novoseek inferred disease relationships for NTSR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 33.2 9 10690540 (5), 10769634 (1), 10816627 (1)
    colon cancer 31.7 6 18541341 (2), 1329682 (1), 9706144 (1), 9935189 (1) (see all 5)
    colon adenocarcinoma 31.6 2 17094477 (1), 16854083 (1)
    adenocarcinoma 23.4 10 18541341 (5), 10816627 (2), 10720480 (1), 9092553 (1)
    prostate cancer 17.7 1 20048080 (1)
    tumors 6.06 21 17094477 (3), 12852770 (3), 18541341 (2), 11786277 (2) (see all 11)
    cancer 0.395 8 10690540 (3), 10769634 (2), 18661521 (1), 10816627 (1)
    schizophrenia 0 6 11032391 (3), 10435199 (2)
    inflammation 0 2 15247267 (1)
    carcinoma 0 2 10690540 (1), 15313463 (1)

    Genetic Association Database (GAD): NTSR1
    Human Genome Epidemiology (HuGE) Navigator: NTSR1 (9 documents)

    Export disorders for NTSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTSR1 gene, integrated from 9 sources (see all 124):
    (articles sorted by number of sources associating them with NTSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    2. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    3. Comprehensive copy number variant (CNV) analysis of n euronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (2010)
    4. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (2009)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Chromosomal localization of mouse and human neurotensin receptor genes. (PubMed id 8075503)1, 3 Laurent P....Rostene W. (1994)
    8. Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. (PubMed id 8381365)1, 2 Vita N.... Caput D. (1993)
    9. Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease. (PubMed id 10690540)1, 9 Wang L....Buchler M.W. (2000)
    10. Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma. (PubMed id 18541341)1, 9 Gui X....Kadkol S.S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4923 HGNC: 8039 AceView: NTSR1 Ensembl:ENSG00000101188 euGenes: HUgn4923
    ECgene: NTSR1 Kegg: 4923 H-InvDB: NTSR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTSR1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Neurotensin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NTSR1 gene:
    Search GeneIP for patents involving NTSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Purified and/or Recombinant NTSR1 Protein
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Clones for the Expression of NTSR1
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     cDNA Clones for NTSR1 (NTS1/NTSR1)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NTSR1  
     OriGene qPCR primer pairs and template standards for NTSR1   OriGene Protein Over-expression Lysate for NTSR1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NTSR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NTSR1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NTSR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NTSR1   OriGene Custom Protein Services for NTSR1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NTSR1
     QIAGEN SeqTarget long-range PCR primers for resequencing NTSR1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTSR1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTSR1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTSR1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTSR1
     GenScript Custom Purified and Recombinant Proteins Services for NTSR1 GenScript cDNA clones with any tag delivered in your preferred vector for NTSR1
     GenScript Custom Assay Services for NTSR1 GenScript Custom Superior Antibodies Services for NTSR1
     GenScript Custom overexpressing Cell Line Services for NTSR1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NTSR1 promoter
     Search Chromatin IP Primers for NTSR1
     RT2 qPCR Primer Assay in human, mouse, rat NTSR1
     GNC Network for NTSR1
     SABiosciences PCR Arrays including human, mouse, rat NTSR1
     Tocris compounds for NTSR1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NTSR1 antibodies
     NTSR1 proteins
     NTSR1 lysates
     Antibodies for NTSR1
     See all of Abcam's Antibodies, Kits and Proteins for NTSR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for NTSR1
     Antibodies for NTSR1
     ELISAs for NTSR1
     CLIAs for NTSR1
     Search LifeMap BioReagents cell lines for NTSR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTSR1
     SwitchGear 3'UTR luciferase reporter plasmids for NTSR1
     SwitchGear Promoter luciferase reporter plasmids for NTSR1
     ThermoFisher Antibody for NTSR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTSR1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for NTSR1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NTSR1
    Customized:
     lentivirus for stable overexpression of NTSR1
     lentivirus expression plasmids for stable overexpression of NTSR1
     adenovirus for overexpression of NTSR1
     LSBio Antibodies in human, mouse, rat for NTSR1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NTSR1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4