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NTSR1 Gene

protein-coding   GIFtS: 65
GCID: GC20P061340

Neurotensin Receptor 1 (High Affinity)

  See NTSR1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neurotensin Receptor 1 (High Affinity)1 2     NTRH2 3
High-Affinity Levocabastine-Insensitive Neurotensin Receptor2 3     NTR2
NT-R-12 3     Neurotensin Receptor Type 12
NTR12 3     NTRR3

External Ids:    HGNC: 80391   Entrez Gene: 49232   Ensembl: ENSG000001011887   OMIM: 1626515   UniProtKB: P309893   

Export aliases for NTSR1 gene to outside databases

Previous GC identifers: GC20P061217 GC20P062019 GC20P062066 GC20P060810 GC20P058057


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NTSR1 Gene:
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the
multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and
regulation of intestinal motility and secretion. (provided by RefSeq, Jul 2008)

GeneCards Summary for NTSR1 Gene:
NTSR1 (neurotensin receptor 1 (high affinity)) is a protein-coding gene. Diseases associated with NTSR1 include hyperglycemia. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled neurotensin receptor activity. An important paralog of this gene is GHSR.

UniProtKB/Swiss-Prot: NTR1_HUMAN, P30989
Function: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a
phosphatidylinositol-calcium second messenger system

summary for NTSR1 Gene:
Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin
receptors; the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single
transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including
modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the
digestive tract and hypothermic and analgesic effects. NTS1 is distributed widely throughout the brain and
gastrointestinal tract, whilst NTS2 is confined to areas of the brain involved in the descending control of
nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS1 and NTS2
receptors are located on chromosomes 20q13 and 2p25.1 respectively.

Gene Wiki entry for NTSR1 (Neurotensin receptor 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the NTSR1 gene promoter:
         GCNF   RelA   NF-kappaB   GATA-2   MEF-2A   POU2F1   GCNF-1   POU2F1a   aMEF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTSR1 promoter sequence
   Search Chromatin IP Primers for NTSR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13

NTSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTSR1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P061340:  view genomic region     (about GC identifiers)

Start:
61,340,189 bp from pter      End:
61,394,123 bp from pter
Size:
53,935 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NTR1_HUMAN, P30989 (See protein sequence)
Recommended Name: Neurotensin receptor type 1  
Size: 418 amino acids; 46259 Da
1 PDB 3D structure from and Proteopedia for NTSR1:
2LYW (3D)    
Secondary accessions: Q9H4H1 Q9H4T5

Explore the universe of human proteins at neXtProt for NTSR1: NX_P30989

Explore proteomics data for NTSR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4, Asn37, Asn41
  • Modification sites at PhosphoSitePlus

  • See NTSR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002522.2  
    ENSEMBL proteins: 
     ENSP00000359532  
    Reactome Protein details: P30989

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NTSR: GPCR / Class A : Neurotensin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: NTS1 receptor
    Neurotensin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003985 NT1_rcpt
     IPR003984 NT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30989

    ProtoNet protein and cluster: P30989

    2 Blocks protein domains:
    IPB003984 Neurotensin receptor signature
    IPB003985 Neurotensin type 1 receptor signature


    UniProtKB/Swiss-Prot: NTR1_HUMAN, P30989
    Similarity: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1
    sub-subfamily


    Find genes that share domains with NTSR1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTR1_HUMAN, P30989
    Function: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a
    phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for NTSR1:
    neurotensin receptor 1,expressed in central and peripheral nervous system,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS8381365
    GO:0005515protein binding IPI--
    GO:0016492G-protein coupled neurotensin receptor activity IMP8381365
         
    Find genes that share ontologies with NTSR1           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ntsr1):
     adipose tissue  behavior/neurological  digestive/alimentary  growth/size/body  homeostasis/metabolism 
     integument  nervous system  normal 

    Find genes that share phenotypes with NTSR1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for NTSR1: Ntsr1tm1Hmno Ntsr1tm1Pang Ntsr1tm2Pang Ntsr1tm2Dgen

       genOway: Develop your customized and physiologically relevant rodent model for NTSR1

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    SwitchGear 3'UTR luciferase reporter plasmidNTSR1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NTR1_HUMAN, P30989: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum4
    golgi apparatus4
    nucleus2
    chloroplast1
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9763490
    GO:0005794Golgi apparatus TAS9763490
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IMP8381365
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with NTSR1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NTSR1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5GPCRs, Other
    GPCRs, Other


    Find genes that share SuperPaths with NTSR1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for NTSR1
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for NTSR1
        Peptide ligand-binding receptors
    G alpha (q) signalling events


    2 Kegg Pathways  (Kegg details for NTSR1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NTSR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NTSR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NTSR1 (P309893 ENSP000003595324) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTSP309903, ENSP000002560104I2D: score=2 STRING: ENSP00000256010
    ARRB2P321213, ENSP000002692604I2D: score=1 STRING: ENSP00000269260
    APPENSP000002849814STRING: ENSP00000284981
    AVPR1AENSP000002991784STRING: ENSP00000299178
    CASRENSP000002961544STRING: ENSP00000296154
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS8381365
    GO:0007218neuropeptide signaling pathway IMP8381365
    GO:0007268synaptic transmission TAS9763490
    GO:0008344adult locomotory behavior IEA--

    Find genes that share ontologies with NTSR1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Compounds for NTSR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JMV 449Potent neurotensin receptor agonist[139026-66-7]
    SR 48692Selective nonpeptide NTS1 antagonist[146362-70-1]
    SR 142948Highly potent NT receptor antagonist[184162-64-9]
    Xenin 8Neurotensin-like peptide; potentiates insulin and glucagon secretion[117442-28-1]
    NeurotensinEndogenous neurotransmitter and endocrine modulator[39379-15-2]

    1 HMDB Compound for NTSR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for NTSR1 (NTS1 receptor) (see all 13)    About this table
    LigandTypeActionAffinityPubmed IDs
    neurotensin
    AgonistFull agonist8.3 - 9.711723247 10930533
    SR142948A
    AntagonistAntagonist8.99023294
    JMV458
    AgonistFull agonist8.811723247
    large neurotensin
    AgonistFull agonist8.711811984
    SR48692
    AntagonistAntagonist8.411723247
    KH28
    AgonistFull agonist7.9216095636
    Thr10contulakin-G
    AgonistFull agonist7.610318778
    large neuromedin N
    AgonistFull agonist7.411811984
    contulakin-G
    AgonistFull agonist610318778
    JMV457
    AgonistFull agonist5.811723247

    7 Novoseek inferred chemical compound relationships for NTSR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sr48692 89.7 6 10533985 (1), 9706144 (1), 18063561 (1), 19195889 (1)
    levocabastine 76.5 4 11304684 (1), 11723247 (1)
    dopamine 10.7 2 10196181 (1), 11890761 (1)
    thymidine 0 1 8047978 (1)
    sodium 0 4 9927610 (3)
    lipid 0 1 16406549 (1)
    calcium 0 2 9706144 (1), 14570823 (1)



    Find genes that share compounds with NTSR1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NTSR1 gene: 
    NM_002531.2  

    Unigene Cluster for NTSR1:

    Neurotensin receptor 1 (high affinity)
    Hs.590869  [show with all ESTs]
    Unigene Representative Sequence: NM_002531
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370501(uc002ydf.3) ENST00000482259
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    Additional mRNA sequence: 

    AY429106.1 BC040711.1 X70070.1 

    1 DOTS entry:

    DT.108187 

    Selected AceView cDNA sequences (see all 29):

    BM759646 BM738353 AY429106 X70070 NM_002531 BX280020 BQ639483 BM757283 
    BQ422484 BM757252 BE292807 BG469552 BE872844 BI915623 BM738161 BC040711 
    AA157908 AL537553 AA078742 U47726 AA079834 AL537552 AA157852 BM738078 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NTSR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTCCGGAG
    NTSR1 Expression
    About this image


    NTSR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Pancreas (Endocrine System)
    NTSR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NTSR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.590869

    UniProtKB/Swiss-Prot: NTR1_HUMAN, P30989
    Tissue specificity: Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear
    cells. Detected at very low levels in brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NTSR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NTSR1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntsr11 , 5 neurotensin receptor 11, 5 84.81(n)1
    86.09(a)1
      2 (103.04 cM)5
    182161  NM_018766.21  NP_061236.11 
     1804999765 
    chicken
    (Gallus gallus)
    Aves NTSR11 neurotensin receptor 1 (high affinity) 73.62(n)
    71.61(a)
      428149  NM_001245982.1  NP_001232911.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTSR16
    neurotensin receptor 1 (high affinity)
    66(a)
    1 ↔ 1
    4(152137996-152285374)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017352971 neurotensin receptor type 1-like 65.43(n)
    56.61(a)
      101735297  XM_004914847.1  XP_004914904.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5693441 neurotensin receptor type 1-like 67.3(n)
    62.26(a)
      569344  XM_692724.5  XP_697816.4 


    ENSEMBL Gene Tree for NTSR1 (if available)
    TreeFam Gene Tree for NTSR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NTSR1 gene
    GHSR2  GPR392  NMUR12  MLNR2  NMUR22  TRHR2  NTSR22  
    6 SIMAP similar genes for NTSR1 using alignment to 1 protein entry:     NTR1_HUMAN:
    NTSR2    GHSR    NMUR1    NMUR2    GPR39    MLNR

    Find genes that share paralogs with NTSR1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NTSR1 (see all 1529)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs615727191,2
    --61338252(+) TTAACC/TGGTGA 1 -- us2k10--------
    rs743790891,2
    C,F--61338260(+) TGAATC/TGTGTC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1872241781,2
    --61338361(+) TCCCCA/GTGGAG 1 -- us2k10--------
    rs48092961,2
    C,F--61338388(+) CCTGCC/TCTTCA 1 -- us2k19Minor allele frequency- T:0.24NA WA CSA EA 370
    rs1916823721,2
    --61338401(+) CAGCCA/GCTATT 1 -- us2k10--------
    rs1478325461,2
    --61338429(+) TCAATC/TGAGGC 1 -- us2k10--------
    rs1838693251,2
    C--61338443(+) GAGACA/GCTAAG 1 -- us2k10--------
    rs1414136711,2
    --61338464(+) CAAATA/GTGAAG 1 -- us2k10--------
    rs1470019101,2
    --61338494(+) TCCTAC/TCTACT 1 -- us2k10--------
    rs1177736771,2
    C,F--61338544(+) CAAGAT/CTTCTA 1 -- us2k11Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for NTSR1 (61340189 - 61394123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NTSR1 (see all 37):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv797e199CNV Deletion23128226
    esv1917595CNV Deletion18987734
    esv2722831CNV Deletion23290073
    esv2722833CNV Deletion23290073
    esv2722828CNV Deletion23290073
    esv2645365CNV Deletion19546169
    esv2658201CNV Deletion23128226
    esv2658283CNV Deletion23128226
    esv2722832CNV Deletion23290073
    esv4782CNV Deletion18987735

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162651    OMIM disorders: --

    1 disease for NTSR1:    
    About MalaCards
    hyperglycemia


    Find genes that share disorders with NTSR1           About GenesLikeMe

    10 Novoseek inferred disease relationships for NTSR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 33.2 9 10690540 (5), 10769634 (1), 10816627 (1)
    colon cancer 31.7 6 18541341 (2), 1329682 (1), 9706144 (1), 9935189 (1) (see all 5)
    colon adenocarcinoma 31.6 2 17094477 (1), 16854083 (1)
    adenocarcinoma 23.4 10 18541341 (5), 10816627 (2), 10720480 (1), 9092553 (1)
    prostate cancer 17.7 1 20048080 (1)
    tumors 6.06 21 17094477 (3), 12852770 (3), 18541341 (2), 11786277 (2) (see all 11)
    cancer 0.395 8 10690540 (3), 10769634 (2), 18661521 (1), 10816627 (1)
    schizophrenia 0 6 11032391 (3), 10435199 (2)
    inflammation 0 2 15247267 (1)
    carcinoma 0 2 10690540 (1), 15313463 (1)

    Genetic Association Database (GAD): NTSR1
    Human Genome Epidemiology (HuGE) Navigator: NTSR1 (9 documents)

    Export disorders for NTSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NTSR1 gene, integrated from 10 sources (see all 129):
    (articles sorted by number of sources associating them with NTSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. (PubMed id 20048080)1, 2, 9 Swift S.L....Maitland N.J. (Cancer Res. 2010)
    2. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    4. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PubMed id 20398908)1, 4 Saus E....Estivill X. (J Psychiatr Res 2010)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    8. Chromosomal localization of mouse and human neurotensin receptor genes. (PubMed id 8075503)1, 3 Laurent P....Rostene W. (Mamm. Genome 1994)
    9. Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. (PubMed id 8381365)1, 2 Vita N.... Caput D. (FEBS Lett. 1993)
    10. Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease. (PubMed id 10690540)1, 9 Wang L....BA1chler M.W. (Clin. Cancer Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4923 HGNC: 8039 AceView: NTSR1 Ensembl:ENSG00000101188 euGenes: HUgn4923
    ECgene: NTSR1 Kegg: 4923 H-InvDB: NTSR1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NTSR1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Neurotensin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NTSR1 gene:
    Search GeneIP for patents involving NTSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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