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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTSR1 Gene

protein-coding   GIFtS: 62
GCID: GC20P061340

neurotensin receptor 1 (high affinity)

 Explore 25 diseases affiliated with
NTSR1 via our new
 Human Malady Compendium 
Biological research products
for NTSR1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Neurotensin Receptor 1 (High Affinity)1 2     NTR12 3
NTR1 2     NTRH2 3
High-Affinity Levocabastine-Insensitive Neurotensin Receptor2 3     Neurotensin Receptor Type 12
NT-R-12 3     NTRR3

External Ids:    HGNC: 80391   Entrez Gene: 49232   Ensembl: ENSG000001011887   OMIM: 1626515   UniProtKB: P309893   

Export aliases for NTSR1 gene to outside databases

Previous GC identifers: GC20P061217 GC20P062019 GC20P062066 GC20P060810 GC20P058057


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTSR1:
Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple
functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of
intestinal motility and secretion. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NTR1_HUMAN, P30989
Function: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a
phosphatidylinositol-calcium second messenger system

summary for NTSR1:
Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin
receptors; the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single
transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including
modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the
digestive tract and hypothermic and analgesic effects. NTS1 is distributed widely throughout the brain and
gastrointestinal tract, whilst NTS2 is confined to areas of the brain involved in the descending control of
nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS1 and NTS2
receptors are located on chromosomes 20q13 and 2p25.1 respectively.

Gene Wiki entry for NTSR1 (Neurotensin receptor 1)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011333.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NTSR1 gene promoter:
         GCNF   RelA   NF-kappaB   GATA-2   MEF-2A   POU2F1   GCNF-1   POU2F1a   aMEF-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTSR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NTSR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13

NTSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTSR1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P061340:  view genomic region     (about GC identifiers)

Start:
61,340,189 bp from pter      End:
61,394,123 bp from pter
Size:
53,935 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NTR1_HUMAN, P30989 (See protein sequence)
Recommended Name: Neurotensin receptor type 1  
Size: 418 amino acids; 46259 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for NTSR1:
2LYW (3D)    
Secondary accessions: Q9H4H1 Q9H4T5

Explore the universe of human proteins at neXtProt for NTSR1: NX_P30989

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30989

  • NTSR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002522.2  
    ENSEMBL proteins: 
     ENSP00000359532  
    Reactome Protein details: P30989
    Human Recombinant Protein Products: 
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    Uscn Proteins for NTSR1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9763490
    GO:0005794Golgi apparatus TAS9763490
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS8381365


    NTSR1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NTSR1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR003985 NT1_rcpt
     IPR003984 NT_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P30989

    ProtoNet protein and cluster: P30989

    2 Blocks protein families:
    IPB003984 Neurotensin receptor signature
    IPB003985 Neurotensin type 1 receptor signature


    UniProtKB/Swiss-Prot: NTR1_HUMAN, P30989
    Similarity: Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NTR1_HUMAN, P30989
    Function: Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a
    phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for NTSR1:
    neurotensin receptor 1,expressed in central and peripheral nervous system,G protein coupled receptor superfamily

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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate NTSR1:
    hsa-miR-579 hsa-miR-607 hsa-miR-2355-3p hsa-miR-885-5p hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidNTSR1 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS8381365
    GO:0016492G-protein coupled neurotensin receptor activity IEA--


    NTSR1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for NTSR1: Ntsr1tm1Hmno Ntsr1tm1Pang Ntsr1tm2Pang Ntsr1tm2Dgen
         8 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ntsr1):
     adipose tissue  behavior/neurological  digestive/alimentary  growth/size  homeostasis/metabolism 
     integument  nervous system  normal 

    NTSR1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)1.00
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.75
    Neuroactive ligand-receptor interaction0.38
    Peptide ligand-binding receptors0.61
    2Signaling by GPCR
    Signaling by GPCR1.00
    Signal Transduction0.56
    GPCR downstream signaling0.89
    3G alpha (q) signalling events
    G alpha (q) signalling events1.00
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    4Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q1.00
    Peptide GPCRs0.46
    5GPCRs, Other
    GPCRs, Other1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NTSR1
        Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q


    3 BioSystems Pathways for NTSR1 
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    5/8        Reactome Pathways for NTSR1 (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding


    2         Kegg Pathways  (Kegg details for NTSR1):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction


    NTSR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NTSR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/128 Interacting proteins for NTSR1 (P309893 ENSP000003595324) via UniProtKB, MINT, STRING, and/or I2D (see all 128)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTSP309903, ENSP000002560104I2D: score=2 STRING: ENSP00000256010
    ARRB2P321213, ENSP000002692604I2D: score=1 STRING: ENSP00000269260
    APPENSP000002849814STRING: ENSP00000284981
    CASRENSP000002961544STRING: ENSP00000296154
    CCKENSP000003356574STRING: ENSP00000335657
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS8381365
    GO:0007268synaptic transmission TAS9763490
    GO:0008344adult locomotory behavior IEA--


    NTSR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NTSR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NTSR1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JMV 449Potent neurotensin receptor agonist[139026-66-7]
    Neuromedin N (rat, mouse, porcine, canine) Neurotensin-like peptide[92169-45-4]
    SR 142948Highly potent NT receptor antagonist[184162-64-9]
    NeurotensinEndogenous neurotransmitter and endocrine modulator[39379-15-2]
    Leelamine hydrochlorideCB1 agonist[1446-61-3]

    1 HMDB Compound for NTSR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    7 Novoseek chemical compound relationships for NTSR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sr48692 89.7 6 10533985 (1), 9706144 (1), 18063561 (1), 19195889 (1)
    levocabastine 76.5 4 11304684 (1), 11723247 (1)
    dopamine 10.7 2 10196181 (1), 11890761 (1)
    thymidine 0 1 8047978 (1)
    sodium 0 4 9927610 (3)
    lipid 0 1 16406549 (1)
    calcium 0 2 9706144 (1), 14570823 (1)

    Search CenterWatch for drugs/clinical trials and news about NTSR1 / NTR1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NTSR1 gene: 
    NM_002531.2  

    Unigene Cluster for NTSR1:

    Neurotensin receptor 1 (high affinity)
    Hs.590869  [show with all ESTs]
    Unigene Representative Sequence: NM_002531
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370501(uc002ydf.3) ENST00000482259

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    Additional cDNA sequence: 

    AY429106.1 BC040711.1 X70070.1 

    1 DOTS entry:

    DT.108187 

    24/29 AceView cDNA sequences (see all 29):

    BM759646 AY429106 BM738353 X70070 BE292807 BI915623 BQ639483 BE872844 
    BG469552 BX280020 BM757252 NM_002531 BC040711 BQ422484 BM757283 BM738161 
    U47726 AA079834 AA078742 AL537553 AA157908 AA157852 BM738078 AL537552 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTSR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGTCCGGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NTSR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTSR1

    SOURCE GeneReport for Unigene cluster: Hs.590869
        SABiosciences Expression via Pathway-Focused PCR Arrays including NTSR1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NTSR1 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves NTSR11 neurotensin receptor 1 (high affinity) 74.58(n)
    72.82(a)
      428149  NM_001245982.1  NP_001232911.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTSR16
    --
    71(a)
    1 ↔ 1
    4(152137922-152138607)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5693441 neurotensin receptor type 1-like 67.88(n)
    63.41(a)
      569344  XM_692724.4  XP_697816.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Pk1r6
    capaR6
    (see all 4)
    capa receptor
    (see all 4)
    23(a)
    20(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    3R(9925554-9928844)
    3L(21552074-21555281)
    worm
    (Caenorhabditis elegans)
    Secernentea nmur-26
    nmur-36
    (see all 3)
    Protein NMUR-3, isoform a
    (see all 3)
    20(a)
    19(a)
    (see all 3)
    possible ortholog
    possible ortholog
    (see all 3)
    II(123339-125004)
    X(4466493-4468980)


    ENSEMBL Gene Tree for NTSR1 (if available)
    TreeFam Gene Tree for NTSR1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTSR1 gene
    GPR392  GHSR2  NMUR12  TRHR2  MLNR2  NMUR22  NTSR22  
    6 SIMAP similar genes for NTSR1 using alignment to 1 protein entry:     NTR1_HUMAN:
    NTSR2    GHSR    NMUR1    NMUR2    GPR39    MLNR

    NTSR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1322 NCBI SNPs in NTSR1 are shown (see all 1322    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs615727191,2
    --61338252(+) TTAACC/TGGTGA 1 -- us2k10--------
    rs743790891,2
    C,F,--61338260(+) TGAATC/TGTGTC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1872241781,2
    --61338361(+) TCCCCA/GTGGAG 1 -- us2k10--------
    rs48092961,2
    C,F,--61338388(+) CCTGCC/TCTTCA 1 -- us2k19Minor allele frequency- T:0.24NA WA CSA EA 370
    rs1916823721,2
    --61338401(+) CAGCCA/GCTATT 1 -- us2k10--------
    rs1478325461,2
    --61338429(+) TCAATC/TGAGGC 1 -- us2k10--------
    rs1838693251,2
    --61338443(+) GAGACA/GCTAAG 1 -- us2k10--------
    rs1414136711,2
    --61338464(+) CAAATA/GTGAAG 1 -- us2k10--------
    rs1470019101,2
    --61338494(+) TCCTAC/TCTACT 1 -- us2k10--------
    rs1177736771,2
    F,--61338544(+) CAAGAT/CTTCTA 1 -- us2k11Minor allele frequency- C:0.02EA 120

    HapMap Linkage Disequilibrium report for NTSR1 (61340189 - 61394123 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for NTSR1
         9 CNVs: 61937 43430 67735 50709 103025 50708 32428 4106 5144
         1 Indel: 46128

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NTSR1 for disorders           About GeneDecksing

    OMIM gene information: 162651    OMIM disorders: --

    20/25 diseases for NTSR1 (see all 25):    About MalaCards
    western equine encephalitis    hyperglycemia    anorexia nervosa    pancreatic ductal carcinoma
    pituitary adenoma    colon adenocarcinoma    hepatitis a    squamous cell carcinoma
    colon cancer    pancreatic cancer    pancreatitis    adenocarcinoma
    prostate cancer    encephalitis    adenoma    pancreatic diseases
    schizophrenia    carcinoma    lung cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for NTSR1:
    Western equine encephalitis

    10 Novoseek disease relationships for NTSR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic cancer 33.2 9 10690540 (5), 10769634 (1), 10816627 (1)
    colon cancer 31.7 6 18541341 (2), 1329682 (1), 9706144 (1), 9935189 (1) (see all 5)
    colon adenocarcinoma 31.6 2 17094477 (1), 16854083 (1)
    adenocarcinoma 23.4 10 18541341 (5), 10816627 (2), 10720480 (1), 9092553 (1)
    prostate cancer 17.7 1 20048080 (1)
    tumors 6.06 21 17094477 (3), 12852770 (3), 18541341 (2), 11786277 (2) (see all 11)
    cancer 0.395 8 10690540 (3), 10769634 (2), 18661521 (1), 10816627 (1)
    schizophrenia 0 6 11032391 (3), 10435199 (2)
    inflammation 0 2 15247267 (1)
    carcinoma 0 2 10690540 (1), 15313463 (1)

    Genetic Association Database (GAD): NTSR1
    Human Genome Epidemiology (HuGE) Navigator: NTSR1 (9 documents)

    Export disorders for NTSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTSR1 gene, integrated from 9 sources (see all 121):
    (articles sorted by number of sources associating them with NTSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    2. Chromosomal localization of mouse and human neurotensin receptor genes. (PubMed id 8075503)1, 3 Laurent P....Rostene W. (1994)
    3. Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. (PubMed id 8381365)1, 2 Vita N.... Caput D. (1993)
    4. Neurotensin receptor-1 mRNA analysis in normal pancreas and pancreatic disease. (PubMed id 10690540)1, 9 Wang L....Buchler M.W. (2000)
    5. Increased neurotensin receptor-1 expression during progression of colonic adenocarcinoma. (PubMed id 18541341)1, 9 Gui X....Kadkol S.S. (2008)
    6. The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression. (PubMed id 19156213)1, 9 Dupouy S....Forgez P. (2009)
    7. Neurotensin receptor 1 immunoreactivity in the periph eral ganglia and carotid body. (PubMed id 19864207)1, 9 Porzionato A....De Caro R. (2009)
    8. The high affinity neurotensin receptor gene (NTSR1): comparative sequencing and association studies in schizophrenia. (PubMed id 11032391)4, 9 Austin J....O'Donovan M.C. (2000)
    9. Intermolecular cross-talk between NTR1 and NTR2 neuro tensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors. (PubMed id 19968961)1, 9 Hwang J.R....Seong J.Y. (2010)
    10. Altered expression of neurotensin receptors is associ ated with the differentiation state of prostate cancer. (PubMed id 20048080)1, 9 Swift S.L....Maitland N.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4923 HGNC: 8039 AceView: NTSR1 Ensembl:ENSG00000101188 euGenes: HUgn4923
    ECgene: NTSR1 Kegg: 4923 H-InvDB: NTSR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTSR1 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Neurotensin_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NTSR1 gene:
    Search GeneIP for patents involving NTSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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