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Aliases for NTSR1 Gene

Aliases for NTSR1 Gene

  • Neurotensin Receptor 1 (High Affinity) 2 3
  • High-Affinity Levocabastine-Insensitive Neurotensin Receptor 3 4
  • NT-R-1 3 4
  • NTR1 3 4
  • NTRH 3 4
  • Neurotensin Receptor Type 1 3
  • NTRR 4
  • NTR 3

External Ids for NTSR1 Gene

Summaries for NTSR1 Gene

Entrez Gene Summary for NTSR1 Gene

  • Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTSR1 Gene

NTSR1 (Neurotensin Receptor 1 (High Affinity)) is a Protein Coding gene. Diseases associated with NTSR1 include hyperglycemia. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled neurotensin receptor activity. An important paralog of this gene is GPR39.

UniProtKB/Swiss-Prot for NTSR1 Gene

  • G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.

Tocris Summary for NTSR1 Gene

  • Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors; the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the digestive tract and hypothermic and analgesic effects. NTS1 is distributed widely throughout the brain and gastrointestinal tract, whilst NTS2 is confined to areas of the brain involved in the descending control of nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS1 and NTS2 receptors are located on chromosomes 20q13 and 2p25.1 respectively.

Gene Wiki entry for NTSR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTSR1 Gene

Genomics for NTSR1 Gene

Genomic Location for NTSR1 Gene

Start:
62,708,837 bp from pter
End:
62,762,771 bp from pter
Size:
53,935 bases
Orientation:
Plus strand

Genomic View for NTSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTSR1 Gene

Regulatory Elements for NTSR1 Gene

Proteins for NTSR1 Gene

  • Protein details for NTSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30989-NTR1_HUMAN
    Recommended name:
    Neurotensin receptor type 1
    Protein Accession:
    P30989
    Secondary Accessions:
    • Q9H4H1
    • Q9H4T5

    Protein attributes for NTSR1 Gene

    Size:
    418 amino acids
    Molecular mass:
    46259 Da
    Quaternary structure:
    • Interacts (palmitoylated form) with GNA11.

    Three dimensional structures from OCA and Proteopedia for NTSR1 Gene

neXtProt entry for NTSR1 Gene

Proteomics data for NTSR1 Gene at MOPED

Post-translational modifications for NTSR1 Gene

  • N-gycosylated
  • Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn4, Asn37, and Asn41

Other Protein References for NTSR1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NTSR1 Gene

Domains for NTSR1 Gene

Gene Families for NTSR1 Gene

HGNC:
  • NTSR :GPCR / Class A : Neurotensin receptors
IUPHAR :

UniProtKB/Swiss-Prot:

NTR1_HUMAN
Domain:
  • The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembranes TM6 and TM7.:
    • P30989
Family:
  • Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.:
    • P30989
genes like me logo Genes that share domains with NTSR1: view

Function for NTSR1 Gene

Molecular function for NTSR1 Gene

GENATLAS Biochemistry: neurotensin receptor 1,expressed in central and peripheral nervous system,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.

Gene Ontology (GO) - Molecular Function for NTSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 8381365
GO:0005515 protein binding IPI 23597562
GO:0016492 G-protein coupled neurotensin receptor activity IMP 8381365
genes like me logo Genes that share ontologies with NTSR1: view
genes like me logo Genes that share phenotypes with NTSR1: view

Animal Models for NTSR1 Gene

MGI Knock Outs for NTSR1:

miRNA for NTSR1 Gene

miRTarBase miRNAs that target NTSR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NTSR1 Gene

Localization for NTSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTSR1 Gene

Cell membrane; Multi-pass membrane protein. Membrane raft. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTSR1 Gene COMPARTMENTS Subcellular localization image for NTSR1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 4
nucleus 2
chloroplast 1
extracellular 1

Gene Ontology (GO) - Cellular Components for NTSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9763490
GO:0005794 Golgi apparatus TAS 9763490
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IMP 8381365
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with NTSR1: view

Pathways for NTSR1 Gene

genes like me logo Genes that share pathways with NTSR1: view

Gene Ontology (GO) - Biological Process for NTSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway TAS 8381365
GO:0007218 neuropeptide signaling pathway IDA 21725197
GO:0007268 synaptic transmission TAS 9763490
GO:0008344 adult locomotory behavior IEA --
GO:0043066 negative regulation of apoptotic process IMP 21725197
genes like me logo Genes that share ontologies with NTSR1: view

Compounds for NTSR1 Gene

(5) Tocris Compounds for NTSR1 Gene

Compound Action Cas Number
JMV 449 Potent neurotensin receptor agonist [139026-66-7]
Neurotensin Endogenous neurotransmitter and endocrine modulator [39379-15-2]
SR 142948 Highly potent NT receptor antagonist [184162-64-9]
SR 48692 Selective nonpeptide NTS1 antagonist [146362-70-1]
Xenin 8 Neurotensin-like peptide; potentiates insulin and glucagon secretion [117442-28-1]

(1) HMDB Compounds for NTSR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(13) IUPHAR Ligand for NTSR1 Gene

Ligand Type Action Affinity Pubmed IDs
SR142948A Antagonist Antagonist 8.9
neurotensin Agonist Full agonist 8.8
JMV458 Agonist Full agonist 8.7
large neurotensin Agonist Full agonist 8.7
KH28 Agonist Full agonist 7.92
Thr10contulakin-G Agonist Full agonist 7.6
large neuromedin N Agonist Full agonist 7.4
JMV2004 Agonist Full agonist 7.2
JMV431 Agonist Full agonist 7
JMV457 Agonist Full agonist 6.8
SR48692 Agonist Full agonist 6.4
contulakin-G Agonist Full agonist 6
JMV449 Agonist Full agonist

(7) Novoseek inferred chemical compound relationships for NTSR1 Gene

Compound -log(P) Hits PubMed IDs
sr48692 89.7 4
levocabastine 76.5 2
dopamine 10.7 2
thymidine 0 1
sodium 0 3
genes like me logo Genes that share compounds with NTSR1: view

Transcripts for NTSR1 Gene

mRNA/cDNA for NTSR1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NTSR1 Gene

Neurotensin receptor 1 (high affinity):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTSR1 Gene

No ASD Table

Relevant External Links for NTSR1 Gene

GeneLoc Exon Structure for
NTSR1
ECgene alternative splicing isoforms for
NTSR1

Expression for NTSR1 Gene

mRNA expression in normal human tissues for NTSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTSR1 Gene

This gene is overexpressed in Colon - Sigmoid (24.7), Whole Blood (6.6), and Colon - Transverse (4.9).

SOURCE GeneReport for Unigene cluster for NTSR1 Gene Hs.590869

mRNA Expression by UniProt/SwissProt for NTSR1 Gene

P30989-NTR1_HUMAN
Tissue specificity: Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain.
genes like me logo Genes that share expressions with NTSR1: view

Orthologs for NTSR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTSR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTSR1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NTSR1 36
  • 87.96 (n)
  • 86.84 (a)
NTSR1 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTSR1 36
  • 89.07 (n)
  • 85.89 (a)
NTSR1 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntsr1 36
  • 84.81 (n)
  • 86.09 (a)
Ntsr1 16
Ntsr1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTSR1 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTSR1 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntsr1 36
  • 83.89 (n)
  • 84.69 (a)
chicken
(Gallus gallus)
Aves NTSR1 36
  • 73.62 (n)
  • 71.61 (a)
NTSR1 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTSR1 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735297 36
  • 65.43 (n)
  • 56.61 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC569344 36
  • 67.3 (n)
  • 62.26 (a)
ntsr1 37
  • 59 (a)
OneToOne
Species with no ortholog for NTSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTSR1 Gene

ENSEMBL:
Gene Tree for NTSR1 (if available)
TreeFam:
Gene Tree for NTSR1 (if available)

Paralogs for NTSR1 Gene

Paralogs for NTSR1 Gene

Selected SIMAP similar genes for NTSR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NTSR1: view

Variants for NTSR1 Gene

Sequence variations from dbSNP and Humsavar for NTSR1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs702120 -- 62,761,876(+) AGAAC(A/G)GGGCC utr-variant-3-prime
rs746192 -- 62,760,625(-) AGCAC(A/C)TTTCA utr-variant-3-prime
rs856933 -- 62,751,745(+) GCCAG(C/T)GGGAT intron-variant
rs856934 -- 62,752,691(+) GTGTT(A/G)GATAC intron-variant
rs856935 -- 62,754,266(+) CCACA(A/G)GACGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTSR1 Gene

Variant ID Type Subtype PubMed ID
dgv4603n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913073 CNV Loss 21882294
dgv1343e1 CNV Complex 17122850
nsv428380 CNV Loss 18775914
nsv834026 CNV Loss 17160897
nsv913106 CNV Loss 21882294
nsv913108 CNV Loss 21882294
nsv3442 CNV Insertion 18451855
nsv913109 CNV Loss 21882294
dgv4613n71 CNV Loss 21882294
dgv4614n71 CNV Loss 21882294
nsv470558 CNV Loss 18288195
dgv4615n71 CNV Loss 21882294
nsv834027 CNV Loss 17160897
esv2658283 CNV Deletion 23128226
dgv4616n71 CNV Loss 21882294
nsv521375 CNV Loss 19592680
nsv515840 CNV Loss 19592680
dgv797e199 CNV Deletion 23128226
esv25803 CNV Loss 19812545
dgv708n67 CNV Loss 20364138
nsv9823 CNV Loss 18304495
esv2722828 CNV Deletion 23290073
esv4782 CNV Deletion 18987735
esv2676431 CNV Deletion 23128226
esv9171 CNV Loss 19470904
nsv828789 CNV Loss 20364138
nsv828790 CNV Loss 20364138
esv2645365 CNV Deletion 19546169
esv1917595 CNV Deletion 18987734
esv2658201 CNV Deletion 23128226
esv2722830 CNV Deletion 23290073
nsv516618 CNV Loss 19592680
esv2722831 CNV Deletion 23290073
esv2722832 CNV Deletion 23290073
esv2722833 CNV Deletion 23290073

Relevant External Links for NTSR1 Gene

HapMap Linkage Disequilibrium report
NTSR1

Disorders for NTSR1 Gene

(1) MalaCards Diseases for NTSR1 Gene

Search for NTSR1 Gene in MalaCards »

(10) Novoseek inferred disease relationships for NTSR1 Gene

Disease -log(P) Hits PubMed IDs
pancreatic cancer 33.2 7
colon cancer 31.7 6
colon adenocarcinoma 31.6 2
adenocarcinoma 23.4 9
prostate cancer 17.7 1

Relevant External Links for NTSR1

Genetic Association Database (GAD)
NTSR1
Human Genome Epidemiology (HuGE) Navigator
NTSR1
genes like me logo Genes that share disorders with NTSR1: view

No data available for UniProtKB/Swiss-Prot for NTSR1 Gene

Publications for NTSR1 Gene

  1. Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. (PMID: 20048080) Swift S.L. … Maitland N.J. (Cancer Res. 2010) 3 4 23
  2. Neurotensin receptor 1 immunoreactivity in the peripheral ganglia and carotid body. (PMID: 19864207) Porzionato A. … De Caro R. (Eur J Histochem 2009) 3 23
  3. Chromosomal localization of mouse and human neurotensin receptor genes. (PMID: 8075503) Laurent P. … Rostene W. (Mamm. Genome 1994) 2 3
  4. Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. (PMID: 8381365) Vita N. … Caput D. (FEBS Lett. 1993) 3 4
  5. Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensin receptor 1. (PMID: 18809332) HAorterich S. … Gmeiner P. (Bioorg. Med. Chem. 2008) 3 23

Products for NTSR1 Gene

  • Addgene plasmids for NTSR1

Sources for NTSR1 Gene

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