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Aliases for NTSR1 Gene

Aliases for NTSR1 Gene

  • Neurotensin Receptor 1 (High Affinity) 2 3
  • High-Affinity Levocabastine-Insensitive Neurotensin Receptor 3 4
  • NT-R-1 3 4
  • NTR1 3 4
  • NTRH 3 4
  • NTRR 4
  • NTR 3

External Ids for NTSR1 Gene

Previous GeneCards Identifiers for NTSR1 Gene

  • GC20P061217
  • GC20P062019
  • GC20P062066
  • GC20P060810
  • GC20P061340
  • GC20P058057

Summaries for NTSR1 Gene

Entrez Gene Summary for NTSR1 Gene

  • Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTSR1 Gene

NTSR1 (Neurotensin Receptor 1 (High Affinity)) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled neurotensin receptor activity. An important paralog of this gene is GPR39.

UniProtKB/Swiss-Prot for NTSR1 Gene

  • G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.

Tocris Summary for NTSR1 Gene

  • Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1).

Gene Wiki entry for NTSR1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTSR1 Gene

Genomics for NTSR1 Gene

Regulatory Elements for NTSR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NTSR1 Gene

Chromosome:
20
Start:
62,708,783 bp from pter
End:
62,762,771 bp from pter
Size:
53,989 bases
Orientation:
Plus strand

Genomic View for NTSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTSR1 Gene

Proteins for NTSR1 Gene

  • Protein details for NTSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30989-NTR1_HUMAN
    Recommended name:
    Neurotensin receptor type 1
    Protein Accession:
    P30989
    Secondary Accessions:
    • Q9H4H1
    • Q9H4T5

    Protein attributes for NTSR1 Gene

    Size:
    418 amino acids
    Molecular mass:
    46259 Da
    Quaternary structure:
    • Interacts (palmitoylated form) with GNA11.

    Three dimensional structures from OCA and Proteopedia for NTSR1 Gene

neXtProt entry for NTSR1 Gene

Proteomics data for NTSR1 Gene at MOPED

Post-translational modifications for NTSR1 Gene

  • N-gycosylated
  • Palmitoylated; this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment.
  • Glycosylation at Asn 4, Asn 37, and Asn 41
  • Modification sites at PhosphoSitePlus

Other Protein References for NTSR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NTSR1 Gene

Domains & Families for NTSR1 Gene

Gene Families for NTSR1 Gene

Suggested Antigen Peptide Sequences for NTSR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P30989

UniProtKB/Swiss-Prot:

NTR1_HUMAN :
  • The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembranes TM6 and TM7.
  • Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.
Domain:
  • The ligand binding pocket consists mainly of extracellular loops ECL2 and ECL3, as well as transmembranes TM6 and TM7.
Family:
  • Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR1 sub-subfamily.
genes like me logo Genes that share domains with NTSR1: view

Function for NTSR1 Gene

Molecular function for NTSR1 Gene

GENATLAS Biochemistry:
neurotensin receptor 1,expressed in central and peripheral nervous system,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.

Gene Ontology (GO) - Molecular Function for NTSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 8381365
GO:0005515 protein binding IPI 23597562
GO:0016492 G-protein coupled neurotensin receptor activity IMP 8381365
GO:0042803 protein homodimerization activity IEA --
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with NTSR1: view
genes like me logo Genes that share phenotypes with NTSR1: view

Animal Models for NTSR1 Gene

MGI Knock Outs for NTSR1:

Animal Model Products

CRISPR Products

miRNA for NTSR1 Gene

miRTarBase miRNAs that target NTSR1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NTSR1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NTSR1 Gene

Localization for NTSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTSR1 Gene

Cell membrane; Multi-pass membrane protein. Membrane raft. Note=Palmitoylation is required for localization at CAV1-enriched membrane rafts.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTSR1 Gene COMPARTMENTS Subcellular localization image for NTSR1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 4
chloroplast 2
mitochondrion 2
nucleus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for NTSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with NTSR1: view

Pathways & Interactions for NTSR1 Gene

genes like me logo Genes that share pathways with NTSR1: view

PCR Array Products

SIGNOR curated interactions for NTSR1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for NTSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001659 temperature homeostasis IEA --
GO:0003085 negative regulation of systemic arterial blood pressure IEA --
GO:0003254 regulation of membrane depolarization IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 8381365
GO:0007218 neuropeptide signaling pathway IDA 21725197
genes like me logo Genes that share ontologies with NTSR1: view

Drugs & Compounds for NTSR1 Gene

(16) Drugs for NTSR1 Gene - From: NovoSeek, IUPHAR, DGIdb, Tocris, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dopamine Approved Pharma Full agonist, Agonist 2814
Levocabastine Approved Pharma Full agonist, Agonist 4
thymidine Experimental Pharma 0
neurotensin Pharma Full agonist, Agonist Endogenous neurotransmitter and endocrine modulator 0
contulakin-G Pharma Full agonist, Agonist 0

(8) Additional Compounds for NTSR1 Gene - From: IUPHAR, NovoSeek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
SR48692
Full agonist, Agonist
JMV449
Full agonist, Agonist
JMV 449
139026-66-7
Kinetensin (human)
103131-69-7
Neuromedin N (rat, mouse, porcine, canine)
92169-45-4
genes like me logo Genes that share compounds with NTSR1: view

Transcripts for NTSR1 Gene

mRNA/cDNA for NTSR1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(29) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NTSR1 Gene

Neurotensin receptor 1 (high affinity):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NTSR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTSR1 Gene

No ASD Table

Relevant External Links for NTSR1 Gene

GeneLoc Exon Structure for
NTSR1
ECgene alternative splicing isoforms for
NTSR1

Expression for NTSR1 Gene

mRNA expression in normal human tissues for NTSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTSR1 Gene

This gene is overexpressed in Colon - Sigmoid (x24.7), Whole Blood (x6.6), and Colon - Transverse (x4.9).

SOURCE GeneReport for Unigene cluster for NTSR1 Gene Hs.590869

mRNA Expression by UniProt/SwissProt for NTSR1 Gene

P30989-NTR1_HUMAN
Tissue specificity: Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain.
genes like me logo Genes that share expression patterns with NTSR1: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for NTSR1 Gene

Orthologs for NTSR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTSR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NTSR1 35
  • 87.96 (n)
  • 86.84 (a)
NTSR1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTSR1 35
  • 89.07 (n)
  • 85.89 (a)
NTSR1 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntsr1 35
  • 84.81 (n)
  • 86.09 (a)
Ntsr1 16
Ntsr1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntsr1 35
  • 83.89 (n)
  • 84.69 (a)
oppossum
(Monodelphis domestica)
Mammalia NTSR1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTSR1 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NTSR1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves NTSR1 35
  • 73.62 (n)
  • 71.61 (a)
NTSR1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTSR1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735297 35
  • 65.43 (n)
  • 56.61 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC569344 35
  • 67.3 (n)
  • 62.26 (a)
ntsr1 36
  • 59 (a)
OneToOne
Species with no ortholog for NTSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTSR1 Gene

ENSEMBL:
Gene Tree for NTSR1 (if available)
TreeFam:
Gene Tree for NTSR1 (if available)

Paralogs for NTSR1 Gene

Paralogs for NTSR1 Gene

(6) SIMAP similar genes for NTSR1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NTSR1: view

Variants for NTSR1 Gene

Sequence variations from dbSNP and Humsavar for NTSR1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs702120 -- 62,761,876(+) AGAAC(A/G)GGGCC utr-variant-3-prime
rs746192 -- 62,760,625(-) AGCAC(A/C)TTTCA utr-variant-3-prime
rs856933 -- 62,751,745(+) GCCAG(C/T)GGGAT intron-variant
rs856934 -- 62,752,691(+) GTGTT(A/G)GATAC intron-variant
rs856935 -- 62,754,266(+) CCACA(A/G)GACGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTSR1 Gene

Variant ID Type Subtype PubMed ID
dgv4603n71 CNV Loss 21882294
nsv459065 CNV Gain 19166990
nsv913073 CNV Loss 21882294
dgv1343e1 CNV Complex 17122850
nsv428380 CNV Loss 18775914
nsv834026 CNV Loss 17160897
nsv913106 CNV Loss 21882294
nsv913108 CNV Loss 21882294
nsv3442 CNV Insertion 18451855
nsv913109 CNV Loss 21882294
dgv4613n71 CNV Loss 21882294
dgv4614n71 CNV Loss 21882294
nsv470558 CNV Loss 18288195
dgv4615n71 CNV Loss 21882294
nsv834027 CNV Loss 17160897
esv2658283 CNV Deletion 23128226
dgv4616n71 CNV Loss 21882294
nsv521375 CNV Loss 19592680
nsv515840 CNV Loss 19592680
dgv797e199 CNV Deletion 23128226
esv25803 CNV Loss 19812545
dgv708n67 CNV Loss 20364138
nsv9823 CNV Loss 18304495
esv2722828 CNV Deletion 23290073
esv4782 CNV Deletion 18987735
esv2676431 CNV Deletion 23128226
esv9171 CNV Loss 19470904
nsv828789 CNV Loss 20364138
nsv828790 CNV Loss 20364138
esv2645365 CNV Deletion 19546169
esv1917595 CNV Deletion 18987734
esv2658201 CNV Deletion 23128226
esv2722830 CNV Deletion 23290073
nsv516618 CNV Loss 19592680
esv2722831 CNV Deletion 23290073
esv2722832 CNV Deletion 23290073
esv2722833 CNV Deletion 23290073

Variation tolerance for NTSR1 Gene

Residual Variation Intolerance Score: 73.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.03; 60.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTSR1 Gene

HapMap Linkage Disequilibrium report
NTSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTSR1 Gene

Disorders for NTSR1 Gene

Relevant External Links for NTSR1

Genetic Association Database (GAD)
NTSR1
Human Genome Epidemiology (HuGE) Navigator
NTSR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NTSR1
genes like me logo Genes that share disorders with NTSR1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NTSR1 Gene

Publications for NTSR1 Gene

  1. Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer. (PMID: 20048080) Swift S.L. … Maitland N.J. (Cancer Res. 2010) 23 67
  2. Synthesis of neurotensin(8-13)-phosphopeptide heterodimers via click chemistry. (PMID: 20452768) Richter S. … Wuest F. (Bioorg. Med. Chem. Lett. 2010) 23 67
  3. Sensorimotor gating in neurotensin-1 receptor null mice. (PMID: 19596359) Feifel D. … Button D. (Neuropharmacology 2010) 23 67
  4. Neurotensin expression and outcome of malignant pleural mesothelioma. (PMID: 19932148) Alifano M. … Forgez P. (Biochimie 2010) 23 67
  5. Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors. (PMID: 19968961) Hwang J.R. … Seong J.Y. (Biochem. Biophys. Res. Commun. 2010) 23 67

Products for NTSR1 Gene

Sources for NTSR1 Gene

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