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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTS Gene

protein-coding   GIFtS: 61
GCID: GC12P086201

Neurotensin

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
neurotensin1 2     NT2
pro-neurotensin/neuromedin1 2     NT/N2
Neuromedin N1     NTS12
NMN-1252     Neurotensin/Neuromedin N2
NN2     

External Ids:    HGNC: 80381   Entrez Gene: 49222   Ensembl: ENSG000001336367   OMIM: 1626505   UniProtKB: P309903   

Export aliases for NTS gene to outside databases

Previous GC identifers: GC12P085876 GC12P086784 GC12P084770 GC12P083324


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTS Gene:
This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted
tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a
neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the
maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing
may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may
represent more stable peptides that are also biologically active. (provided by RefSeq, Jul 2008)

GeneCards Summary for NTS Gene: 
NTS (neurotensin) is a protein-coding gene. Diseases associated with NTS include dumping syndrome, and duodenogastric reflux, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding. GO annotations related to this gene include neuropeptide hormone activity.

UniProtKB/Swiss-Prot: NEUT_HUMAN, P30990
Function: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes
contraction of smooth muscle

summary for NTS Gene:
Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin
receptors; the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single
transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including
modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the
digestive tract and hypothermic and analgesic effects.

Gene Wiki entry for NTS (Neurotensin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NTS gene promoter:
         LHX3b/Lhx3b   Bach2   FOXD1   MyoD   Nkx2-5   CREB   deltaCREB   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTS promoter sequence
   Search SABiosciences Chromatin IP Primers for NTS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21   Ensembl cytogenetic band:  12q21.31   HGNC cytogenetic band: 12q21.31

NTS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTS gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P086201:  view genomic region     (about GC identifiers)

Start:
86,268,073 bp from pter      End:
86,276,770 bp from pter
Size:
8,698 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEUT_HUMAN, P30990 (See protein sequence)
Recommended Name: Neurotensin/neuromedin N precursor  
Size: 170 amino acids; 19795 Da
Subcellular location: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Packaged within secretory vesicles
5 PDB 3D structures from and Proteopedia for NTS:
2LNE (3D)        2LNF (3D)        2LNG (3D)        2LYW (3D)        3F6K (3D)    

Explore the universe of human proteins at neXtProt for NTS: NX_P30990

Explore proteomics data for NTS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30990

  • NTS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NTS Protein Expression
    REFSEQ proteins: NP_006174.1  
    ENSEMBL proteins: 
     ENSP00000448328   ENSP00000256010  
    Reactome Protein details: P30990
    Human Recombinant Protein Products for NTS: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NTS
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for NTS
    GenScript Custom Purified and Recombinant Proteins Services for NTS
    Novus Biologicals NTS Proteins
    Novus Biologicals NTS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NTS
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0030133transport vesicle IEA--

    NTS for ontologies           About GeneDecksing



    NTS Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NTS
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    Abcam antibodies for NTS
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibodies for NTS
    LSBio Antibodies in human, mouse, rat for NTS 

    Assay Products for NTS: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for NTS
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR008055 NeurotensiN

    Graphical View of Domain Structure for InterPro Entry P30990

    ProtoNet protein and cluster: P30990

    1 Blocks protein domain: IPB008055 Neurotensin/neuromedin N precursor signature

    UniProtKB/Swiss-Prot: NEUT_HUMAN, P30990
    Similarity: Belongs to the neurotensin family


    NTS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NEUT_HUMAN, P30990
    Function: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes
    contraction of smooth muscle

         Genatlas biochemistry entry for NTS:
    neurotensin,19.7kDa,tridecapeptide expressed in various brain regions,modulating dopaminergic neuronal
    activity,and released from the N cells of small intestine,responsible for regulatory and trophic effets,including
    gut motility

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005184neuropeptide hormone activity IEA--
    GO:0005515protein binding IPI--
         
    NTS for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Nts):
     adipose tissue  behavior/neurological  growth/size  homeostasis/metabolism  nervous system 
     no phenotypic analysis 

    NTS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ntstm1Dob for NTS

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NTS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NTS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTS 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTS
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate NTS:
    hsa-miR-130a* hsa-miR-23c hsa-miR-570 hsa-miR-23b hsa-miR-377 hsa-miR-23a hsa-miR-548c-3p hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidNTS 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NTS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTS

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of NTS

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NTS (see all 6)
    OriGene ORF clones in mouse, rat for NTS
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    GenScript: all cDNA clones in your preferred vector: NTS (NM_006183)
    Sino Biological Human cDNA Clone for NTS
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTS
    Sirion Biotech Customized lentivirus for stable overexpression of NTS 
                         Customized lentivirus expression plasmids for stable overexpression of NTS 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NTS About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    3G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/8        Reactome Pathways for NTS (see all 8)
        GPCR downstream signaling
    Peptide ligand-binding receptors
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    GPCR ligand binding



    NTS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NTS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/132 Interacting proteins for NTS (P309903 ENSP000002560104) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTSR1P309893, ENSP000003595324I2D: score=2 STRING: ENSP00000359532
    ACE2Q9BYF13, ENSP000002525194I2D: score=1 STRING: ENSP00000252519
    ARRB2P321213, ENSP000002692604I2D: score=1 STRING: ENSP00000269260
    NLNQ9BYT83, ENSP000003703724I2D: score=1 STRING: ENSP00000370372
    PREPP481473, ENSP000003581064I2D: score=1 STRING: ENSP00000358106
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS8954810
    GO:0050880regulation of blood vessel size IEA--

    NTS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NTS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NTS available from Tocris Bioscience    About this table
    CompoundAction CAS #
    JMV 449Potent neurotensin receptor agonist[139026-66-7]
    SR 48692Selective nonpeptide NTS1 antagonist[146362-70-1]
    SR 142948Highly potent NT receptor antagonist[184162-64-9]
    Xenin 8Neurotensin-like peptide; potentiates insulin and glucagon secretion[117442-28-1]
    NeurotensinEndogenous neurotransmitter and endocrine modulator[39379-15-2]

    10/135 Novoseek inferred chemical compound relationships for NTS gene (see all 135)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sr48692 90.9 27 9128997 (5), 9692718 (2), 9167771 (2), 8528577 (1) (see all 11)
    sr142948a 83.8 9 12379249 (2), 18838494 (2), 10579568 (2), 9554803 (1) (see all 5)
    nt69l 83.6 11 11525773 (2), 11430916 (1), 14511764 (1), 19800922 (1) (see all 6)
    kinetensin 81.4 10 1800960 (2), 1309362 (1), 7748196 (1)
    levocabastine 79.1 13 10579568 (2), 7516053 (1), 7852427 (1), 9851594 (1) (see all 8)
    oxyntomodulin 77.7 14 2293569 (2), 8359644 (2), 8418694 (2), 11091116 (1) (see all 10)
    dopamine 61.5 200 1776128 (9), 10095083 (7), 1328532 (7), 1655979 (6) (see all 66)
    alpha msh 57.3 3 9751493 (1), 10657511 (1), 14500581 (1)
    thimet 57.1 4 11355859 (1), 17251185 (1), 9735321 (1)
    cyclo(his-pro) 48 2 1728838 (1), 8489134 (1)

    Search CenterWatch for drugs/clinical trials and news about NTS / NEUT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NTS gene: 
    NM_006183.4  

    Unigene Cluster for NTS:

    Neurotensin
    Hs.80962  [show with all ESTs]
    Unigene Representative Sequence: BF698911
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000551529 ENST00000256010(uc001tag.3) ENST00000550879

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTS
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate NTS:
    hsa-miR-130a* hsa-miR-23c hsa-miR-570 hsa-miR-23b hsa-miR-377 hsa-miR-23a hsa-miR-548c-3p hsa-miR-497*
    SwitchGear 3'UTR luciferase reporter plasmidNTS 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NTS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTS
    Clone
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    OriGene clones in human, mouse for NTS (see all 6)
    OriGene ORF clones in mouse, rat for NTS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NTS (NM_006183)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTS
    Sirion Biotech Customized lentivirus for stable overexpression of NTS 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTS

    Additional mRNA sequence: 

    AF157682.1 AK312066.1 BC010918.1 CR541936.1 U91618.1 

    7 DOTS entries:

    DT.91778734  DT.121200057  DT.100748881  DT.95369432  DT.121200070  DT.40129576  DT.95369427 

    24/223 AceView cDNA sequences (see all 223):

    BC010918 BX112463 BM798822 AA928656 AW103921 AW340829 NM_006183 BM782021 
    BM762353 AU076817 AW571577 AU100456 BG195493 AF157682 BQ007059 BM782067 
    BM564579 BM782065 CR541936 BG192398 BM839862 BG199052 BM798654 BG611702 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for NTS    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for NTS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTS expression in normal human tissues (normalized intensities)      NTS embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTGTGAT
    NTS Expression
    About this image


    NTS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 26 entries
             Globus Pallidus
             Substantia Nigra   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 12 entries
             Line H7 (WA07)
             ESI-017   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Interstitial Stroma
             visceral organ/metanephros/renal medulla   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Human corneal endothelial cells
             blood vessel   

    See NTS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTS

    SOURCE GeneReport for Unigene cluster: Hs.80962
        SABiosciences Expression via Pathway-Focused PCR Array including NTS: 
              Obesity in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NTS gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nts1 , 5 neurotensin1, 5 83.04(n)1
    81.66(a)1
      10 (53.56 cM)5
    674051  NM_024435.21  NP_077755.11 
     1024817605 
    chicken
    (Gallus gallus)
    Aves NTS1 neurotensin 75.61(n)
    67.07(a)
      417883  XM_416126.3  XP_416126.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTS6
    Uncharacterized protein
    64(a)
    1 ↔ 1
    5(34417679-34441717)
    zebrafish
    (Danio rerio)
    Actinopterygii nts6
    neurotensin
    32(a)
    1 ↔ 1
    18(15989139-15998685)


    ENSEMBL Gene Tree for NTS (if available)
    TreeFam Gene Tree for NTS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/262 SNPs in NTS are shown (see all 262)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37640401,2
    C,F,A,H--86266125(-) TTCATT/CTTAAA 1 -- us2k120Minor allele frequency- C:0.30NS EA NA WA CSA 2320
    rs582103871,2
    --86266149(+) TTCTCC/TCCCTT 1 -- us2k10--------
    rs1862238131,2
    --86266244(+) TTAGAC/TTGCTA 1 -- us2k10--------
    rs714521231,2
    C,F--86266247(+) GACTGC/TTATCA 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs1908560561,2
    --86266341(+) ATTTTC/TCCGAT 1 -- us2k10--------
    rs1382186591,2
    --86266343(+) TTTCCC/GGATTT 1 -- us2k10--------
    rs1834535151,2
    --86266351(+) TTTGTC/TAATCA 1 -- us2k10--------
    rs1877774441,2
    --86266642(+) TTTCTG/TGTATT 1 -- us2k10--------
    rs1919261571,2
    --86266643(+) TTCTGA/GTATTA 1 -- us2k10--------
    rs1829446951,2
    --86266804(+) TGTTAC/TTACAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NTS (86268073 - 86276770 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for NTS:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1042104CNV Insertion17803354


    Human Gene Mutation Database (HGMD): NTS
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NTS
    DNA2.0 Custom Variant and Variant Library Synthesis for NTS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 162650    OMIM disorders: --

    20/99 diseases for NTS (see all 99):    About MalaCards
    dumping syndrome    duodenogastric reflux    hypochondriasis    thyroid medullary carcinoma
    vipoma    short bowel syndrome    pain agnosia    ileus
    gastroesophageal reflux disease    pancreatic islet cell tumors    nicotine addiction    pancreatic ductal carcinoma
    zollinger-ellison syndrome    restless legs syndrome    carcinoid syndrome    islet cell tumor
    obstructive jaundice    colon adenocarcinoma    sudden infant death syndrome    dyspepsia

    5 diseases from the University of Copenhagen DISEASES database for NTS:
    Schizophrenia     Pain agnosia     Dumping syndrome     Neuroblastoma
    Parkinson's disease

    NTS for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/92 Novoseek inferred disease relationships for NTS gene (see all 92)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neuroendocrine tumors 53.2 2 17426390 (1), 15706438 (1)
    carcinoid 48.6 17 1659338 (2), 7720675 (2), 15358593 (2), 16338793 (2) (see all 12)
    schizophrenia 47.1 54 15006494 (4), 11032391 (4), 11743941 (3), 17190526 (3) (see all 25)
    pancreatic cancer 44.3 51 8387763 (3), 14613990 (3), 9061071 (3), 12768332 (2) (see all 15)
    motility disorder 39.6 2 15637765 (1), 18019689 (1)
    dumping syndrome 37.6 1 9403815 (1)
    vipoma 32.8 1 8128360 (1)
    adenocarcinoma 31.6 23 10209952 (2), 17870207 (2), 9353137 (1), 12150975 (1) (see all 15)
    porphyria hepatic 31.1 1 10225763 (1)
    pancreatic carcinoma 31 6 15389644 (1), 10365121 (1), 11912133 (1), 12750255 (1)

    Genetic Association Database (GAD): NTS
    Human Genome Epidemiology (HuGE) Navigator: NTS (8 documents)

    Export disorders for NTS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTS gene, integrated from 9 sources (see all 780):
    (articles sorted by number of sources associating them with NTS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls. (PubMed id 1436492)1, 2, 9 Bean A.J.... Dobner P.R. (1992)
    2. Genetic association studies of neurotensin gene and restless legs syndrome in French Canadians. (PubMed id 17644423)1, 4, 9 Xiong L....Rouleau G.A. (2008)
    3. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. DNA methylation contributes to expression of the human neurotensin/neuromedin N gene. (PubMed id 9530155)1, 2 Dong Z.... Evers B.M. (1998)
    7. Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity. (PubMed id 11811984)1, 9 Friry C....Rovere C. (2002)
    8. Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways. (PubMed id 17068197)1, 9 Li J....Evers B.M. (2007)
    9. Over-expression of neurotensin high-affinity receptor 1 (NTS1) in relation with its ligand neurotensin (NT) and nuclear beta-catenin in inflammatory bowel disease-related oncogenesis. (PubMed id 17870207)1, 9 Bossard C....Laboisse C.L. (2007)
    10. Neurotensin expression and outcome of malignant pleur al mesothelioma. (PubMed id 19932148)1, 9 Alifano M....Forgez P. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4922 HGNC: 8038 AceView: NTS Ensembl:ENSG00000133636 euGenes: HUgn4922
    ECgene: NTS H-InvDB: NTS

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTS Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Neurotensin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NTS gene:
    Search GeneIP for patents involving NTS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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