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Aliases for NTS Gene

Aliases for NTS Gene

  • Neurotensin 2 3 5
  • Pro-Neurotensin/Neuromedin 2 3
  • Neurotensin/Neuromedin N 3
  • Neuromedin N 2
  • NMN-125 3
  • NT/N 3
  • NTS1 3
  • NT 3
  • NN 3

External Ids for NTS Gene

Previous GeneCards Identifiers for NTS Gene

  • GC12P086784
  • GC12P086201
  • GC12P084770
  • GC12P083324

Summaries for NTS Gene

Entrez Gene Summary for NTS Gene

  • This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]

GeneCards Summary for NTS Gene

NTS (Neurotensin) is a Protein Coding gene. Diseases associated with NTS include Duodenogastric Reflux and Dumping Syndrome. Among its related pathways are Peptide ligand-binding receptors and RET signaling. GO annotations related to this gene include neuropeptide hormone activity.

UniProtKB/Swiss-Prot for NTS Gene

  • Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

Tocris Summary for NTS Gene

  • Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1).

Gene Wiki entry for NTS Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTS Gene

Genomics for NTS Gene

Regulatory Elements for NTS Gene

Enhancers for NTS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G085947 0.5 ENCODE 12.3 +74.4 74390 2.5 POU5F1 CHD7 ETS1 MGAT4C NTS ENSG00000258178
GH12G085873 1 Ensembl ENCODE 0.7 +0.0 41 0.9 CTCF ZBTB21 ZSCAN4 POLR2A ZNF366 ZBTB48 PATZ1 ZNF600 PRDM10 KLF8 MGAT4C ENSG00000258178 NTS
GH12G085867 0.6 ENCODE 0.4 -7.0 -6968 0.1 CTCF PKNOX1 ZNF654 TRIM22 ZNF2 RAD21 SMC3 FOS FOXP2 RASSF9 NTS
GH12G085843 0.5 ENCODE 0.3 -30.2 -30174 0.9 ZNF680 GABPB1 HNF4A MGAT4C RASSF9 NTS
GH12G085951 0.6 ENCODE 0.2 +77.8 77762 0.2 CTCF ZNF654 GATA3 SMC3 CHD7 RAD21 RFX5 ENSG00000258178 NTS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NTS on UCSC Golden Path with GeneCards custom track

Genomic Location for NTS Gene

Chromosome:
12
Start:
85,874,295 bp from pter
End:
85,882,992 bp from pter
Size:
8,698 bases
Orientation:
Plus strand

Genomic View for NTS Gene

Genes around NTS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTS Gene

Proteins for NTS Gene

  • Protein details for NTS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30990-NEUT_HUMAN
    Recommended name:
    Neurotensin/neuromedin N
    Protein Accession:
    P30990

    Protein attributes for NTS Gene

    Size:
    170 amino acids
    Molecular mass:
    19795 Da
    Quaternary structure:
    • Interacts with NTSR1. Interacts with SORT1.

    Three dimensional structures from OCA and Proteopedia for NTS Gene

neXtProt entry for NTS Gene

Post-translational modifications for NTS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NTS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NTS Gene

Domains & Families for NTS Gene

Gene Families for NTS Gene

Protein Domains for NTS Gene

Suggested Antigen Peptide Sequences for NTS Gene

Graphical View of Domain Structure for InterPro Entry

P30990

UniProtKB/Swiss-Prot:

NEUT_HUMAN :
  • Belongs to the neurotensin family.
Family:
  • Belongs to the neurotensin family.
genes like me logo Genes that share domains with NTS: view

Function for NTS Gene

Molecular function for NTS Gene

GENATLAS Biochemistry:
neurotensin,19.7kDa,tridecapeptide expressed in various brain regions,modulating dopaminergic neuronal activity,and released from the N cells of small intestine,responsible for regulatory and trophic effets,including gut motility
UniProtKB/Swiss-Prot Function:
Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.

Gene Ontology (GO) - Molecular Function for NTS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005184 neuropeptide hormone activity IBA --
genes like me logo Genes that share ontologies with NTS: view
genes like me logo Genes that share phenotypes with NTS: view

Animal Models for NTS Gene

MGI Knock Outs for NTS:

Animal Model Products

CRISPR Products

miRNA for NTS Gene

miRTarBase miRNAs that target NTS

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NTS

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTS Gene

Localization for NTS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTS Gene

Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Packaged within secretory vesicles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTS gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytoskeleton 2
cytosol 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for NTS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0043679 axon terminus IBA --
genes like me logo Genes that share ontologies with NTS: view

Pathways & Interactions for NTS Gene

genes like me logo Genes that share pathways with NTS: view

SIGNOR curated interactions for NTS Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for NTS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 8954810
GO:0050880 regulation of blood vessel size IEA --
genes like me logo Genes that share ontologies with NTS: view

Drugs & Compounds for NTS Gene

(90) Drugs for NTS Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
JMV 449 Pharma Potent neurotensin receptor agonist 0
Neurotensin Pharma Full agonist, Agonist NTR1 activator, Endogenous neurotransmitter and endocrine modulator 0
SR 142948 Pharma Highly potent NT receptor antagonist 0
SR 48692 Pharma nonpeptide neurotensin antagonist, Selective non-peptide NTS1 antagonist 0

(50) Additional Compounds for NTS Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NTRC 824
1623002-61-8

(5) Tocris Compounds for NTS Gene

Compound Action Cas Number
JMV 449 Potent neurotensin receptor agonist 139026-66-7
Neurotensin Endogenous neurotransmitter and endocrine modulator 39379-15-2
NTRC 824 Potent and selective non-peptide NTS2 antagonist 1623002-61-8
SR 142948 Highly potent NT receptor antagonist 184162-64-9
SR 48692 Selective non-peptide NTS1 antagonist 146362-70-1
genes like me logo Genes that share compounds with NTS: view

Transcripts for NTS Gene

mRNA/cDNA for NTS Gene

Unigene Clusters for NTS Gene

Neurotensin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NTS

Alternative Splicing Database (ASD) splice patterns (SP) for NTS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for NTS Gene

GeneLoc Exon Structure for
NTS
ECgene alternative splicing isoforms for
NTS

Expression for NTS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTS Gene

This gene is overexpressed in Pituitary (x13.7), Brain - Hypothalamus (x10.3), Small Intestine - Terminal Ileum (x8.6), and Brain - Hippocampus (x4.1).

Protein differential expression in normal tissues from HIPED for NTS Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NTS Gene



Protein tissue co-expression partners for NTS Gene

NURSA nuclear receptor signaling pathways regulating expression of NTS Gene:

NTS

SOURCE GeneReport for Unigene cluster for NTS Gene:

Hs.80962

Evidence on tissue expression from TISSUES for NTS Gene

  • Nervous system(4.8)
  • Intestine(3.1)
  • Stomach(3)
  • Blood(2.3)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with NTS: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NTS Gene

Orthologs for NTS Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTS 34 35
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia NTS 34 35
  • 92.16 (n)
cow
(Bos Taurus)
Mammalia NTS 34 35
  • 91.18 (n)
mouse
(Mus musculus)
Mammalia Nts 34 16 35
  • 83.04 (n)
rat
(Rattus norvegicus)
Mammalia Nts 34
  • 80.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NTS 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTS 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves NTS 34 35
  • 75.81 (n)
lizard
(Anolis carolinensis)
Reptilia NTS 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nts 34
  • 71.89 (n)
zebrafish
(Danio rerio)
Actinopterygii nts 35
  • 30 (a)
OneToOne
Species where no ortholog for NTS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTS Gene

ENSEMBL:
Gene Tree for NTS (if available)
TreeFam:
Gene Tree for NTS (if available)

Paralogs for NTS Gene

No data available for Paralogs for NTS Gene

Variants for NTS Gene

Sequence variations from dbSNP and Humsavar for NTS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs869025243 Uncertain significance 85,878,394(+) TGTTT(A/G)CAGTC reference, missense
rs1000086228 -- 85,880,929(+) CCTGG(C/G)CGACA intron-variant
rs1000168927 -- 85,880,799(+) TACAA(A/G)AAATT intron-variant
rs1000418544 -- 85,881,276(+) TGGTT(A/G)TAAGA intron-variant
rs1000706589 -- 85,873,878(+) GATTT(A/C)ATGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NTS Gene

Variant ID Type Subtype PubMed ID
dgv1539n100 CNV gain 25217958
esv1042104 CNV insertion 17803354
esv3630250 CNV loss 21293372
esv3892241 CNV gain 25118596
esv3892242 CNV loss 25118596
nsv1049179 CNV gain 25217958

Variation tolerance for NTS Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTS Gene

Human Gene Mutation Database (HGMD)
NTS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTS Gene

Disorders for NTS Gene

MalaCards: The human disease database

(32) MalaCards diseases for NTS Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
duodenogastric reflux
dumping syndrome
  • dumping syndrome
vipoma
  • malignant vasoactive intestinal peptide-secreting tumor
postgastrectomy syndrome
  • postgastric surgery syndrome
oropouche fever
  • oropouche virus disease
- elite association - COSMIC cancer census association via MalaCards
Search NTS in MalaCards View complete list of genes associated with diseases

Relevant External Links for NTS

Genetic Association Database (GAD)
NTS
Human Genome Epidemiology (HuGE) Navigator
NTS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NTS
genes like me logo Genes that share disorders with NTS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTS Gene

Publications for NTS Gene

  1. Genetic association studies of neurotensin gene and restless legs syndrome in French Canadians. (PMID: 17644423) Xiong L. … Rouleau G.A. (Sleep Med. 2008) 3 22 46 64
  2. Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls. (PMID: 1436492) Bean A.J. … Dobner P.R. (Neuroscience 1992) 3 4 22 64
  3. Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor. (PMID: 23140271) Da Costa G. … Monti J.P. (J. Biomol. Struct. Dyn. 2013) 3 4 64
  4. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  5. The regulatory role of neurotensin on the hypothalamic-anterior pituitary axons: emphasis on the control of thyroid-related functions. (PMID: 19878995) Stolakis V. … Liapi C. (Neuropeptides 2010) 3 22 64

Products for NTS Gene

Sources for NTS Gene

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