Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NTS Gene

protein-coding GIFtS: 60
GCID: GC12P086201

neurotensin

Explore 104 diseases affiliated with
NTS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neurotensin¹		NT/N²
NMN-125²		NTS1²
NN²		Neurotensin/Neuromedin N²
NT²

External Ids:	HGNC: 8038¹	Entrez Gene: 4922²	Ensembl: ENSG00000133636⁷	OMIM: 162650⁵	UniProtKB: P30990³

Export aliases for NTS gene to outside databases

Previous GC identifers: GC12P085876 GC12P086784 GC12P084770 GC12P083324

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTS:

This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted

tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a

neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the

maintenance of gut structure and function, and in the regulation of fat metabolism. Tissue-specific processing may

lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent

more stable peptides that are also biologically active. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NEUT_HUMAN, P30990

Function: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes

contraction of smooth muscle

summary for NTS:

Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin

receptors; the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single

transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including

modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the

digestive tract and hypothermic and analgesic effects.

Gene Wiki entry for NTS (Neurotensin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NTS gene promoter:
LHX3b/Lhx3b Bach2 FOXD1 MyoD Nkx2-5 CREB deltaCREB LHX3a/Lhx3a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NTS promoter sequence

Search SABiosciences Chromatin IP Primers for NTS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21 Ensembl cytogenetic band: 12q21.31 HGNC cytogenetic band: 12q21.31

NTS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTS gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P086201: view genomic region (about GC identifiers)

Start:	86,268,073 bp from pter	End:	86,276,767 bp from pter
Size:	8,695 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NEUT_HUMAN, P30990 (See protein sequence)

Recommended Name: Neurotensin/neuromedin N precursor

Size: 170 amino acids; 19795 Da

Subcellular location: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Packaged within secretory vesicles

5 PDB 3D structures from and Proteopedia for NTS:

2LNE (3D)

2LNF (3D)

2LNG (3D)

2LYW (3D)

3F6K (3D)

Explore the universe of human proteins at neXtProt for NTS: NX_P30990

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30990

NTS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006174.1

ENSEMBL proteins:

ENSP00000448328 ENSP00000256010 ENSP00000447659

Reactome Protein details: P30990
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: NTS OriGene Custom Protein Services for NTS
	GenScript Custom Purified and Recombinant Proteins Services for NTS
	Novus Biologicals NTS Proteins Novus Biologicals NTS Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NTS

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005625	soluble fraction	--	--
GO:0030133	transport vesicle	IEA	--

NTS for ontologies About GeneDecksing

NTS Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NTS
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for NTS
	GenScript Superior Antibodies for NTS
	Novus Biologicals NTS Antibodies
	Search for Antibodies for NTS at Abcam
	Uscn Antibodies for NTS
	ThermoFisher Antibodies for NTS

Assay Products for NTS:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NTS
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NTS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NTS for domains About GeneDecksing

1 InterPro domain/family:

IPR008055 NeurotensiN

Graphical View of Domain Structure for InterPro Entry P30990

ProtoNet protein and cluster: P30990

1 Blocks protein family: IPB008055 Neurotensin/neuromedin N precursor signature

UniProtKB/Swiss-Prot: NEUT_HUMAN, P30990

Similarity: Belongs to the neurotensin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NEUT_HUMAN, P30990

Function: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes

contraction of smooth muscle

Genatlas biochemistry entry for NTS:

neurotensin,19.7kDa,tridecapeptide expressed in various brain regions,modulating dopaminergic neuronal activity,and

released from the N cells of small intestine,responsible for regulatory and trophic effets,including gut motility

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTS
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate NTS:
		hsa-miR-130a* hsa-miR-23c hsa-miR-570 hsa-miR-23b hsa-miR-377 hsa-miR-23a hsa-miR-548c-3p hsa-miR-497*

		SwitchGear 3'UTR luciferase reporter plasmid: NTS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTS (see all 7) OriGene shRNA RFP: NTS OriGene siRNA: NTS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTS

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NTS

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTS (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTS OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NTS (NM_006183)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NTS
		Search LifeMap BioReagents cell lines for NTS

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTS

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005184	neuropeptide hormone activity	IEA	--

NTS for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Nts^tm1Dob for NTS
     6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Nts):

adipose tissue	behavior/neurological	growth/size	homeostasis/metabolism	nervous system
no phenotypic analysis

NTS for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

5/8 Reactome Pathways for NTS (see all 8)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	GPCR ligand binding

NTS for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NTS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/132 Interacting proteins for NTS (P30990³ ENSP00000256010⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 132)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NTSR1	P30989³, ENSP00000359532⁴	I2D: score=2 STRING: ENSP00000359532
ACE2	Q9BYF1³, ENSP00000252519⁴	I2D: score=1 STRING: ENSP00000252519
ARRB2	P32121³, ENSP00000269260⁴	I2D: score=1 STRING: ENSP00000269260
NLN	Q9BYT8³, ENSP00000370372⁴	I2D: score=1 STRING: ENSP00000370372
PREP	P48147³, ENSP00000358106⁴	I2D: score=1 STRING: ENSP00000358106

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	NAS	8954810
GO:0050880	regulation of blood vessel size	IEA	--

NTS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NTS for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for NTS available from Tocris Bioscience About this table

Compound	Action	CAS #
Xenin 8	Neurotensin-like peptide; potentiates insulin and glucagon secretion	[117442-28-1]
JMV 449	Potent neurotensin receptor agonist	[139026-66-7]
Neurotensin	Endogenous neurotransmitter and endocrine modulator	[39379-15-2]
Neuromedin N (rat, mouse, porcine, canine)	Neurotensin-like peptide	[92169-45-4]
SR 142948	Highly potent NT receptor antagonist	[184162-64-9]

10/135 Novoseek chemical compound relationships for NTS gene (see all 135) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sr48692	90.9	27	9128997 (5), 9692718 (2), 9167771 (2), 8528577 (1) (see all 11)
sr142948a	83.8	9	12379249 (2), 18838494 (2), 10579568 (2), 9554803 (1) (see all 5)
nt69l	83.6	11	11525773 (2), 11430916 (1), 14511764 (1), 19800922 (1) (see all 6)
kinetensin	81.4	10	1800960 (2), 1309362 (1), 7748196 (1)
levocabastine	79.1	13	10579568 (2), 7516053 (1), 7852427 (1), 9851594 (1) (see all 8)
oxyntomodulin	77.7	14	2293569 (2), 8359644 (2), 8418694 (2), 11091116 (1) (see all 10)
dopamine	61.5	200	1776128 (9), 10095083 (7), 1328532 (7), 1655979 (6) (see all 66)
alpha msh	57.3	3	9751493 (1), 10657511 (1), 14500581 (1)
thimet	57.1	4	11355859 (1), 17251185 (1), 9735321 (1)
cyclo(his-pro)	48	2	1728838 (1), 8489134 (1)

Search CenterWatch for drugs/clinical trials and news about NTS / NEUT

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NTS gene:

NM_006183.4

Unigene Cluster for NTS:

Neurotensin

Hs.80962 [show with all ESTs]

Unigene Representative Sequence: BF698911

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000551529 ENST00000256010(uc001tag.3) ENST00000550879

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTS
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate NTS:
		hsa-miR-130a* hsa-miR-23c hsa-miR-570 hsa-miR-23b hsa-miR-377 hsa-miR-23a hsa-miR-548c-3p hsa-miR-497*

		SwitchGear 3'UTR luciferase reporter plasmid: NTS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTS (see all 7) OriGene shRNA RFP: NTS OriGene siRNA: NTS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTS

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTS (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTS OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: NTS (NM_006183)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTS

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NTS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTS

Additional cDNA sequence:

AF157682.1 AK312066.1 BC010918.1 CR541936.1 U91618.1

7 DOTS entries:

DT.91778734 DT.121200057 DT.100748881 DT.95369432 DT.121200070 DT.40129576 DT.95369427

24/223 AceView cDNA sequences (see all 223):

AU076817 AA928656 BC010918 BM839862 BQ007059 BX112463 BM782067 BG199052

BM782065 BG195493 BM782021 AF157682 AW571577 BM798822 AU100456 BM564579

BM798654 BG192398 AW103921 NM_006183 CR541936 AW340829 BM762353 BG217930

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for NTS About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b
SP1:
SP2:					-

ECgene alternative splicing isoforms for NTS

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NTS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGATTGTGAT

About this image

NTS expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Mature Granulosa Cells

Ovary

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Adipose

Interscapular Brown Adipose Depot

Adipose

Brain

Kidney

Neural Tube

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H7 (WA07) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Ventral/hypothalamic-like neurons (Generation of midbra...)

See NTS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NTS

SOURCE GeneReport for Unigene cluster: Hs.80962

SABiosciences Expression via Pathway-Focused PCR Array including NTS:

Obesity in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NTS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTS

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NTS gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Nts^{1 , 5}	neurotensin^{1, 5}	83.04(n)¹ 81.66(a)¹		10 (53.56 cM)⁵ 67405¹ NM_024435.2¹ NP_077755.1¹ 102481760⁵
chicken (Gallus gallus)	Aves	NTS¹	neurotensin	75.61(n) 67.07(a)		417883 XM_416126.3 XP_416126.1
lizard (Anolis carolinensis)	Reptilia	NTS⁶	--	64(a)	1 ↔ 1	5(34420987-34440877)
zebrafish (Danio rerio)	Actinopterygii	nts⁶	neurotensin	33(a)	1 ↔ 1	18(15989139-15998685)

ENSEMBL Gene Tree for NTS (if available)
TreeFam Gene Tree for NTS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3764040^1,2	C,F,A,H,	--	86266125(-)	`TTCATT/CTTAAA`	1	--	us2k¹		20		NS EA NA WA CSA	2320
rs58210387^1,2		--	86266149(+)	`TTCTCC/TCCCTT`	1	--	us2k¹		0	--	--	--	--
rs186223813^1,2		--	86266244(+)	`TTAGAC/TTGCTA`	1	--	us2k¹		0	--	--	--	--
rs71452123^1,2	C,F,	--	86266247(+)	`GACTGC/TTATCA`	1	--	us2k¹		2		NA	4
rs190856056^1,2		--	86266341(+)	`ATTTTC/TCCGAT`	1	--	us2k¹		0	--	--	--	--
rs138218659^1,2		--	86266343(+)	`TTTCCC/GGATTT`	1	--	us2k¹		0	--	--	--	--
rs183453515^1,2		--	86266351(+)	`TTTGTC/TAATCA`	1	--	us2k¹		0	--	--	--	--
rs187777444^1,2		--	86266642(+)	`TTTCTG/TGTATT`	1	--	us2k¹		0	--	--	--	--
rs191926157^1,2		--	86266643(+)	`TTCTGA/GTATTA`	1	--	us2k¹		0	--	--	--	--
rs182944695^1,2		--	86266804(+)	`TGTTAC/TTACAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NTS (86268073 - 86276767 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NTS: --
Human Gene Mutation Database (HGMD): NTS

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NTS

DNA2.0 Custom Variant and Variant Library Synthesis for NTS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NTS for disorders           About GeneDecksing

OMIM gene information: 162650    OMIM disorders: --

20/104 diseases for NTS (see all 104):    About MalaCards

sudden infant death syndrome zollinger-ellison syndrome duodenogastric reflux gastroesophageal reflux disease

supranuclear palsy progressive supranuclear palsy islet cell tumor dumping syndrome

restless legs syndrome short bowel syndrome pancreatic islet cell tumors vipoma

eating disorder inflammatory bowel disease bulimia nervosa amyotrophic lateral sclerosis

hypochondriasis pituitary adenoma drug dependence essential hypertension

5 diseases from the University of Copenhagen DISEASES database for NTS:

Schizophrenia Pain agnosia Dumping syndrome Neuroblastoma

Parkinson's disease

10/92 Novoseek disease relationships for NTS gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neuroendocrine tumors	53.2	2	17426390 (1), 15706438 (1)
carcinoid	48.6	17	1659338 (2), 7720675 (2), 15358593 (2), 16338793 (2) (see all 12)
schizophrenia	47.1	54	15006494 (4), 11032391 (4), 11743941 (3), 17190526 (3) (see all 25)
pancreatic cancer	44.3	51	8387763 (3), 14613990 (3), 9061071 (3), 12768332 (2) (see all 15)
motility disorder	39.6	2	15637765 (1), 18019689 (1)
dumping syndrome	37.6	1	9403815 (1)
vipoma	32.8	1	8128360 (1)
adenocarcinoma	31.6	23	10209952 (2), 17870207 (2), 9353137 (1), 12150975 (1) (see all 15)
porphyria hepatic	31.1	1	10225763 (1)
pancreatic carcinoma	31	6	15389644 (1), 10365121 (1), 11912133 (1), 12750255 (1)

Genetic Association Database (GAD): NTS
Human Genome Epidemiology (HuGE) Navigator: NTS (8 documents)

Export disorders for NTS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NTS gene, integrated from 9 sources (see all 776):
(articles sorted by number of sources associating them with NTS)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls. (PubMed id 1436492)^{1, 2, 9} Bean A.J.... Dobner P.R. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
DNA methylation contributes to expression of the human neurotensin/neuromedin N gene. (PubMed id 9530155)^{1, 2} Dong Z.... Evers B.M. (1998)
Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity. (PubMed id 11811984)^{1, 9} Friry C....Rovere C. (2002)
Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways. (PubMed id 17068197)^{1, 9} Li J....Evers B.M. (2007)
Over-expression of neurotensin high-affinity receptor 1 (NTS1) in relation with its ligand neurotensin (NT) and nuclear beta-catenin in inflammatory bowel disease-related oncogenesis. (PubMed id 17870207)^{1, 9} Bossard C....Laboisse C.L. (2007)
Neurotensin expression and outcome of malignant pleur al mesothelioma. (PubMed id 19932148)^{1, 9} Alifano M....Forgez P. (2010)
Expression of neurotensin and its receptors in pituitary adenomas. (PubMed id 18624930)^{1, 9} Giorgi R.R....Correa-Giannella M.L. (2008)
Inhibition of mitochondrial gene transcription suppresses neurotensin secretion in the human carcinoid cell line BON. (PubMed id 15358593)^{1, 9} Li N....Evers B.M. (2005)
The role of protein kinase D in neurotensin secretion mediated by protein kinase C-alpha/-delta and Rho/Rho kinase. (PubMed id 15123666)^{1, 9} Li J....Evers B.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4922	HGNC: 8038	AceView: NTS	Ensembl:ENSG00000133636	euGenes: HUgn4922
ECgene: NTS	H-InvDB: NTS

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NTS	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Neurotensin

Intellectual Property for NTS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for NTS gene:
Search GeneIP for patents involving NTS

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of NTS
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for NTS
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTS		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTS
	OriGene Protein Over-expression Lysate for NTS		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for NTS		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTS		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTS
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for NTS		OriGene Custom Protein Services for NTS
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NTS
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NTS
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTS
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTS
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTS
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTS

	GenScript Custom Purified and Recombinant Proteins Services for NTS		GenScript cDNA clones with any tag delivered in your preferred vector for NTS
	GenScript Custom Assay Services for NTS		GenScript Superior Antibodies for NTS
	GenScript Custom overexpressing Cell Line Services for NTS		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in NTS promoter
	Search Chromatin IP Primers for NTS
	RT² qPCR Primer Assay in human, mouse, rat NTS
	GNC Network for NTS
	SABiosciences PCR Arrays including human, mouse, rat NTS

Tocris compounds for NTS

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	NTS antibodies
	NTS proteins
	NTS lysates

	Search for Antibodies for NTS at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for NTS
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

NTS Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for NTS

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTS

	SwitchGear 3'UTR luciferase reporter plasmids for NTS
	SwitchGear Promoter luciferase reporter plasmids for NTS

ThermoFisher Antibodies for NTS

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTS

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes NTS gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

NTS Gene

neurotensin

Aliases
for NTS gene

Summaries
for NTS gene

Genomic Views
for NTS gene

Proteins
for NTS gene

Protein Domains /
Families
for NTS gene

Function
for NTS gene

Pathways & Interactions
for NTS gene

Drugs & Compounds
for NTS gene

Transcripts
for NTS gene

Expression
for NTS gene

Orthologs
for NTS gene

Paralogs
for NTS gene

Genomic Variants
for NTS gene

Disorders / Diseases
for NTS gene

Publications
for NTS gene

External Searches for NTS gene

Genome Databases showing NTS gene

Other Databases showing NTS gene

Specialized Databases showing NTS gene

Intellectual Property
for NTS gene

Products
for NTS gene

View Random Gene

Gastroesophageal reflux disease
essential hypertension
Eating Disorders
Cystic Fibrosis
Lymphoma T-Cell
dysplasia
Colitis Ulcerative
aggressiveness
COLON CARCINOMA
Duodenogastric Reflux
Myocardial Ischemia
Ischemia
Breast Cancer
Hyperthyroidism
Esophagitis
NSCLC
primary tumor
Schizophrenia
Adenocarcinoma
Asthma
THYROID CARCINOMA MEDULLARY
Cancer
Hypotension
Porphyria Hepatic
Colorectal Carcinoma
Lymphoma
Pathological Processes
COLON ADENOCARCINOMA
Shock
motility disorder
Colorectal Cancer
Epilepsy
PANCREAS EXOCRINE
Inflammation
Vipoma
Insulinoma
Arrhythmia
immunodeficiency
psychiatric disorder
aqueous humor
prostate cancer
Tumors
Metastasis
Pheochromocytoma
prostatic adenocarcinoma
Necrosis
SMOKING HABIT
progressive disease
Senile Plaques
Parkinsonism
Huntington Disease
Neurodegenerative Diseases
Critically Ill
Colon Cancer
Neurological Disorders
Parkinson Disease
Pancreatic Insufficiency
Hyperplasia
Glioma
PITUITARY ADENOMA
Carcinoma
Sudden infant death syndrome
Astrocytoma
Leukemia
PROSTATE CARCINOMA
Alzheimers Disease
Short Bowel Syndrome
Carcinoid
Effects Cardiovascular
Pancreatic Cancer
Cancer Lung
chronic pancreatitis
small cell lung cancer
Inflammatory Bowel Diseases
Neuroendocrine Tumors
Drug Addiction
Meningioma
Adenoma
OBESITY
Ewings sarcoma
solid tumor
Gastritis
Dumping Syndrome
Atrophy
STROKE
PANCREATIC CARCINOMA
Diarrhea chronic
Cholera
NIDDM
Catalepsy
Psychotic
Renal Failure Chronic

Advanced Search

Export list of displayed genes

NTS Gene

neurotensin

Aliasesfor NTS gene

Summariesfor NTS gene

Genomic Viewsfor NTS gene

Proteinsfor NTS gene

Protein Domains /Familiesfor NTS gene

Functionfor NTS gene

Pathways & Interactionsfor NTS gene

Drugs & Compoundsfor NTS gene

Transcriptsfor NTS gene

Expression for NTS gene

Orthologsfor NTS gene

Paralogsfor NTS gene

Genomic Variantsfor NTS gene

Disorders / Diseasesfor NTS gene

Publicationsfor NTS gene

External Searches for NTS gene

Genome Databases showing NTS gene

Other Databases showing NTS gene

Specialized Databases showing NTS gene

Intellectual Propertyfor NTS gene

Productsfor NTS gene

View Random Gene

Aliases
for NTS gene

Summaries
for NTS gene

Genomic Views
for NTS gene

Proteins
for NTS gene

Protein Domains /
Families
for NTS gene

Function
for NTS gene

Pathways & Interactions
for NTS gene

Drugs & Compounds
for NTS gene

Transcripts
for NTS gene

Expression
for NTS gene

Orthologs
for NTS gene

Paralogs
for NTS gene

Genomic Variants
for NTS gene

Disorders / Diseases
for NTS gene

Publications
for NTS gene

Intellectual Property
for NTS gene

Products
for NTS gene