Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NTS Gene

Aliases for NTS Gene

  • Neurotensin 2 3
  • Pro-Neurotensin/Neuromedin 2 3
  • Neurotensin/Neuromedin N 3
  • Neuromedin N 2
  • NMN-125 3
  • NT/N 3
  • NTS1 3
  • NT 3
  • NN 3

External Ids for NTS Gene

Previous GeneCards Identifiers for NTS Gene

  • GC12P086784
  • GC12P086201
  • GC12P084770
  • GC12P083324

Summaries for NTS Gene

Entrez Gene Summary for NTS Gene

  • This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. Neurotensin is a secreted tridecapeptide, which is widely distributed throughout the central nervous system, and may function as a neurotransmitter or a neuromodulator. It may be involved in dopamine-associated pathophysiological events, in the maintenance of gut structure and function, and in the regulation of fat metabolism. Neurotensin also exhibits antimicrobial activity against bacteria and fungi. Tissue-specific processing may lead to the formation in some tissues of larger forms of neuromedin N and neurotensin. The large forms may represent more stable peptides that are also biologically active. [provided by RefSeq, Oct 2014]

GeneCards Summary for NTS Gene

NTS (Neurotensin) is a Protein Coding gene. Diseases associated with NTS include duodenogastric reflux and dumping syndrome. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neuropeptide hormone activity.

UniProtKB/Swiss-Prot for NTS Gene

  • Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle

Tocris Summary for NTS Gene

  • Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors; the G-protein-coupled receptors NTS1 (high affinity) and NTS2 (low affinity) and the single transmembrane receptor NTS3 (Sortilin 1). These receptors have many central and peripheral actions including modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the digestive tract and hypothermic and analgesic effects.

Gene Wiki entry for NTS Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTS Gene

Genomics for NTS Gene

Regulatory Elements for NTS Gene

Genomic Location for NTS Gene

Start:
85,874,295 bp from pter
End:
85,882,992 bp from pter
Size:
8,698 bases
Orientation:
Plus strand

Genomic View for NTS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTS Gene

Proteins for NTS Gene

  • Protein details for NTS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30990-NEUT_HUMAN
    Recommended name:
    Neurotensin/neuromedin N
    Protein Accession:
    P30990
    Secondary Accessions:

    Protein attributes for NTS Gene

    Size:
    170 amino acids
    Molecular mass:
    19795 Da
    Quaternary structure:
    • Interacts with NTSR1. Interacts with SORT1.

    Three dimensional structures from OCA and Proteopedia for NTS Gene

neXtProt entry for NTS Gene

Proteomics data for NTS Gene at MOPED

Post-translational modifications for NTS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NTS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NTS Gene

Domains for NTS Gene

Gene Families for NTS Gene

HGNC:

Protein Domains for NTS Gene

Suggested Antigen Peptide Sequences for NTS Gene

Graphical View of Domain Structure for InterPro Entry

P30990

UniProtKB/Swiss-Prot:

NEUT_HUMAN :
  • P30990
Family:
  • Belongs to the neurotensin family.
genes like me logo Genes that share domains with NTS: view

Function for NTS Gene

Molecular function for NTS Gene

GENATLAS Biochemistry: neurotensin,19.7kDa,tridecapeptide expressed in various brain regions,modulating dopaminergic neuronal activity,and released from the N cells of small intestine,responsible for regulatory and trophic effets,including gut motility
UniProtKB/Swiss-Prot Function: Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle

Gene Ontology (GO) - Molecular Function for NTS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005184 neuropeptide hormone activity IEA --
GO:0005515 protein binding IPI 23597562
genes like me logo Genes that share ontologies with NTS: view
genes like me logo Genes that share phenotypes with NTS: view

Animal Models for NTS Gene

MGI Knock Outs for NTS:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for NTS Gene

Localization for NTS Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTS Gene

Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Packaged within secretory vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTS Gene COMPARTMENTS Subcellular localization image for NTS gene
Compartment Confidence
extracellular 5
nucleus 3
cytoskeleton 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NTS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0030133 transport vesicle IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with NTS: view

Pathways for NTS Gene

genes like me logo Genes that share pathways with NTS: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for NTS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 8954810
GO:0050880 regulation of blood vessel size IEA --
genes like me logo Genes that share ontologies with NTS: view

Compounds for NTS Gene

(5) Tocris Compounds for NTS Gene

Compound Action Cas Number
JMV 449 Potent neurotensin receptor agonist [139026-66-7]
Neurotensin Endogenous neurotransmitter and endocrine modulator [39379-15-2]
SR 142948 Highly potent NT receptor antagonist [184162-64-9]
SR 48692 Selective nonpeptide NTS1 antagonist [146362-70-1]
Xenin 8 Neurotensin-like peptide; potentiates insulin and glucagon secretion [117442-28-1]

(135) Novoseek inferred chemical compound relationships for NTS Gene

Compound -log(P) Hits PubMed IDs
sr48692 90.9 17
sr142948a 83.8 8
nt69l 83.6 7
kinetensin 81.4 4
levocabastine 79.1 9
genes like me logo Genes that share compounds with NTS: view

Transcripts for NTS Gene

mRNA/cDNA for NTS Gene

Unigene Clusters for NTS Gene

Neurotensin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NTS

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NTS

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for NTS Gene

GeneLoc Exon Structure for
NTS
ECgene alternative splicing isoforms for
NTS

Expression for NTS Gene

mRNA expression in normal human tissues for NTS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTS Gene

This gene is overexpressed in Pituitary (13.7), Brain - Hypothalamus (10.3), Small Intestine - Terminal Ileum (8.6), and Brain - Hippocampus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NTS Gene

SOURCE GeneReport for Unigene cluster for NTS Gene Hs.80962

genes like me logo Genes that share expressions with NTS: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NTS Gene

Orthologs for NTS Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTS 35
  • 99.22 (n)
  • 98.82 (a)
NTS 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NTS 35
  • 91.18 (n)
  • 90.59 (a)
NTS 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTS 35
  • 92.16 (n)
  • 90 (a)
NTS 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nts 35
  • 83.04 (n)
  • 81.66 (a)
Nts 16
Nts 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTS 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTS 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nts 35
  • 80.47 (n)
  • 77.51 (a)
chicken
(Gallus gallus)
Aves NTS 35
  • 75.81 (n)
  • 67.07 (a)
NTS 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTS 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nts 35
  • 71.89 (n)
  • 62.65 (a)
zebrafish
(Danio rerio)
Actinopterygii nts 36
  • 30 (a)
OneToOne
Species with no ortholog for NTS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTS Gene

ENSEMBL:
Gene Tree for NTS (if available)
TreeFam:
Gene Tree for NTS (if available)

Paralogs for NTS Gene

No data available for Paralogs for NTS Gene

Variants for NTS Gene

Sequence variations from dbSNP and Humsavar for NTS Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1050926 -- 85,882,522(+) TAATA(G/T)AAATT utr-variant-3-prime
rs1800832 -- 85,874,401(+) GCTGA(A/G)AGATG utr-variant-5-prime
rs2234762 -- 85,874,237(+) CTGTA(C/G)AATCA upstream-variant-2KB
rs3764039 -- 85,873,672(-) AAAAA(G/T)AAATA upstream-variant-2KB
rs3764040 -- 85,872,347(-) TTCAT(C/T)TTAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NTS Gene

Variant ID Type Subtype PubMed ID
esv1042104 CNV Insertion 17803354

Relevant External Links for NTS Gene

HapMap Linkage Disequilibrium report
NTS
Human Gene Mutation Database (HGMD)
NTS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTS Gene

Disorders for NTS Gene

MalaCards: The human disease database

MalaCards: The human disease database. (15) Diseases for NTS Gene including...

Search for NTS Gene in MalaCards »

(5) University of Copenhagen DISEASES for NTS Gene

(92) Novoseek inferred disease relationships for NTS Gene

Disease -log(P) Hits PubMed IDs
neuroendocrine tumors 53.2 2
carcinoid 48.6 16
schizophrenia 47.1 39
pancreatic cancer 44.3 26
motility disorder 39.6 2

Relevant External Links for NTS

Genetic Association Database (GAD)
NTS
Human Genome Epidemiology (HuGE) Navigator
NTS
genes like me logo Genes that share disorders with NTS: view

No data available for UniProtKB/Swiss-Prot for NTS Gene

Publications for NTS Gene

  1. Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls. (PMID: 1436492) Bean A.J. … Dobner P.R. (Neuroscience 1992) 3 4 23
  2. Genetic association studies of neurotensin gene and restless legs syndrome in French Canadians. (PMID: 17644423) Xiong L. … Rouleau G.A. (Sleep Med. 2008) 3 23 48
  3. Neurotensin phosphorylates GSK-3alpha/beta through the activation of PKC in human colon cancer cells. (PMID: 16984735) Wang Q. … Evers B.M. (Neoplasia 2006) 3 23
  4. PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells. (PMID: 17570131) Yuan J. … Rozengurt E. (J. Cell. Biochem. 2008) 3 23
  5. Cyclic adenosine 5'-monophosphate-stimulated neurotensin secretion is mediated through Rap1 downstream of both Epac and protein kinase A signaling pathways. (PMID: 17068197) Li J. … Evers B.M. (Mol. Endocrinol. 2007) 3 23

Products for NTS Gene

Sources for NTS Gene

Back to Top

Content