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Aliases for NTRK3 Gene

Aliases for NTRK3 Gene

  • Neurotrophic Receptor Tyrosine Kinase 3 2 3
  • Neurotrophic Tyrosine Kinase, Receptor, Type 3 2 3 5
  • EC 2.7.10.1 4 63
  • GP145-TrkC 3 4
  • TRKC 3 4
  • ETS Related Protein-Neurotrophic Receptor Tyrosine Kinase Fusion Protein 3
  • Neurotrophic Tyrosine Kinase Receptor Type 3 4
  • Tyrosine Kinase Receptor C 3
  • TrkC Tyrosine Kinase 4
  • ETV6-NTRK3 Fusion 3
  • Gp145(TrkC) 3
  • EC 2.7.10 63
  • Trk-C 4

External Ids for NTRK3 Gene

Previous GeneCards Identifiers for NTRK3 Gene

  • GC15M084556
  • GC15M081649
  • GC15M086007
  • GC15M086149
  • GC15M086221
  • GC15M088402
  • GC15M064532
  • GC15M088418

Summaries for NTRK3 Gene

Entrez Gene Summary for NTRK3 Gene

  • This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for NTRK3 Gene

NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3) is a Protein Coding gene. Diseases associated with NTRK3 include fibrosarcoma and congenital mesoblastic nephroma. Among its related pathways are Alzheimers Disease Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ALK.

UniProtKB/Swiss-Prot for NTRK3 Gene

  • Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

Gene Wiki entry for NTRK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTRK3 Gene

Genomics for NTRK3 Gene

Regulatory Elements for NTRK3 Gene

Promoters for NTRK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NTRK3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the NTRK3 gene promoter:

Genomic Location for NTRK3 Gene

Chromosome:
15
Start:
87,859,751 bp from pter
End:
88,256,796 bp from pter
Size:
397,046 bases
Orientation:
Minus strand

Genomic View for NTRK3 Gene

Genes around NTRK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTRK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTRK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTRK3 Gene

Proteins for NTRK3 Gene

  • Protein details for NTRK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16288-NTRK3_HUMAN
    Recommended name:
    NT-3 growth factor receptor
    Protein Accession:
    Q16288
    Secondary Accessions:
    • B7Z4C5
    • E9PG56
    • H0YND1
    • O75682
    • Q12827
    • Q16289

    Protein attributes for NTRK3 Gene

    Size:
    839 amino acids
    Molecular mass:
    94428 Da
    Quaternary structure:
    • Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NTRK3 Gene

    Alternative splice isoforms for NTRK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTRK3 Gene

Proteomics data for NTRK3 Gene at MOPED

Post-translational modifications for NTRK3 Gene

  • Ligand-mediated auto-phosphorylation.
  • Glycosylation at Asn 72, Asn 79, Asn 133, Asn 163, Asn 203, Asn 218, Asn 232, Asn 259, Asn 267, Asn 272, Asn 294, Asn 375, and Asn 388
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for NTRK3 (TrkC)
  • Cloud-Clone Corp. Antibodies for NTRK3

Domains & Families for NTRK3 Gene

Graphical View of Domain Structure for InterPro Entry

Q16288

UniProtKB/Swiss-Prot:

NTRK3_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
  • Contains 2 LRR (leucine-rich) repeats.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 LRRCT domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Similarity:
  • Contains 2 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NTRK3: view

Function for NTRK3 Gene

Molecular function for NTRK3 Gene

GENATLAS Biochemistry:
receptor tyrosine kinase C,linking neurotrophin 3 (NTF3),containing a CGG repeat in 5utr,with a translocation t(12;15)(p13;q25) in congenital fibrosarcoma (CFS) and in congenital mesoblastic nephroma (CMN),involved in the survival and differentiation of nervous system and heart,and in tumour development
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

Enzyme Numbers (IUBMB) for NTRK3 Gene

Gene Ontology (GO) - Molecular Function for NTRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA --
GO:0043121 neurotrophin binding TAS 7806211
genes like me logo Genes that share ontologies with NTRK3: view
genes like me logo Genes that share phenotypes with NTRK3: view

Human Phenotype Ontology for NTRK3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NTRK3 Gene

MGI Knock Outs for NTRK3:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for NTRK3 Gene

Localization for NTRK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTRK3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTRK3 Gene COMPARTMENTS Subcellular localization image for NTRK3 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
cytosol 3
nucleus 3
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for NTRK3 Gene

Pathways & Interactions for NTRK3 Gene

genes like me logo Genes that share pathways with NTRK3: view

SIGNOR curated interactions for NTRK3 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NTRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001933 negative regulation of protein phosphorylation IDA 23027130
GO:0001934 positive regulation of protein phosphorylation TAS 19036963
GO:0006468 protein phosphorylation IEA --
GO:0007507 heart development IMP 25196463
GO:0010628 positive regulation of gene expression IDA 23027130
genes like me logo Genes that share ontologies with NTRK3: view

Drugs & Compounds for NTRK3 Gene

(11) Drugs for NTRK3 Gene - From: IUPHAR, DGIdb, HMDB, Novoseek, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Crizotinib Approved Pharma C-MET/ALK inhibitor,potent and ATP-competitve, cMET Inhibitors, Kinase Inhibitors, Anaplastic lymphoma kinase (ALK) inhibitor, Potent c-MET/ALK inhibitor 92
Adenosine triphosphate Approved Nutra 0
neurotrophin-3 Pharma 0
tyrosine Nutra 596
AZD1332 Pharma 0

(9) Additional Compounds for NTRK3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with NTRK3: view

Transcripts for NTRK3 Gene

Unigene Clusters for NTRK3 Gene

Neurotrophic tyrosine kinase, receptor, type 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTRK3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6:

ExUns: 24b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for NTRK3 Gene

GeneLoc Exon Structure for
NTRK3
ECgene alternative splicing isoforms for
NTRK3

Expression for NTRK3 Gene

mRNA expression in normal human tissues for NTRK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTRK3 Gene

This gene is overexpressed in Artery - Tibial (x6.0) and Artery - Coronary (x4.2).

Protein differential expression in normal tissues from HIPED for NTRK3 Gene

This gene is overexpressed in Frontal cortex (29.9), Fetal Brain (17.7), and Brain (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NTRK3 Gene



SOURCE GeneReport for Unigene cluster for NTRK3 Gene Hs.410969

mRNA Expression by UniProt/SwissProt for NTRK3 Gene

Q16288-NTRK3_HUMAN
Tissue specificity: Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
genes like me logo Genes that share expression patterns with NTRK3: view

Protein tissue co-expression partners for NTRK3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NTRK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTRK3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NTRK3 35
  • 92.98 (n)
  • 98.78 (a)
-- 36
  • 97 (a)
OneToMany
NTRK3 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NTRK3 35
  • 91.45 (n)
  • 97.98 (a)
NTRK3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntrk3 35
  • 91.03 (n)
  • 97.21 (a)
Ntrk3 16
Ntrk3 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NTRK3 35
  • 99.39 (n)
  • 99.76 (a)
NTRK3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntrk3 35
  • 90.98 (n)
  • 97.26 (a)
oppossum
(Monodelphis domestica)
Mammalia NTRK3 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
chicken
(Gallus gallus)
Aves NTRK3 35
  • 82.12 (n)
  • 88.92 (a)
NTRK3 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ntrk3 35
  • 75.09 (n)
  • 85.18 (a)
zebrafish
(Danio rerio)
Actinopterygii ntrk1 35
ntrk3a 35
  • 71.42 (n)
  • 75.92 (a)
ntrk3a 36
  • 78 (a)
OneToMany
ntrk3b 36
  • 77 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y69E1A.3 37
  • 33 (a)
trk-1 36
  • 22 (a)
OneToMany
Species with no ortholog for NTRK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTRK3 Gene

ENSEMBL:
Gene Tree for NTRK3 (if available)
TreeFam:
Gene Tree for NTRK3 (if available)

Paralogs for NTRK3 Gene

Paralogs for NTRK3 Gene

genes like me logo Genes that share paralogs with NTRK3: view

Variants for NTRK3 Gene

Sequence variations from dbSNP and Humsavar for NTRK3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_041471 A gastric adenocarcinoma sample
rs56386352 - 88,135,389(+) CACAC(A/G)TGGGG nc-transcript-variant, reference, missense
VAR_041473 A lung adenocarcinoma sample
VAR_041474 A lung adenocarcinoma sample
VAR_041475 A lung adenocarcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for NTRK3 Gene

Variant ID Type Subtype PubMed ID
nsv94255 CNV Loss 16902084
esv2749991 CNV Deletion 23290073
nsv527970 CNV Gain 19592680
esv2608620 CNV Deletion 19546169
esv271976 CNV Insertion 20981092
nsv904475 CNV Gain 21882294
nsv904476 CNV Gain 21882294
nsv827427 CNV Gain 20364138

Variation tolerance for NTRK3 Gene

Residual Variation Intolerance Score: 3.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTRK3 Gene

HapMap Linkage Disequilibrium report
NTRK3
Human Gene Mutation Database (HGMD)
NTRK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTRK3 Gene

Disorders for NTRK3 Gene

MalaCards: The human disease database

(23) MalaCards diseases for NTRK3 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fibrosarcoma
  • fibrocytic tumor
congenital mesoblastic nephroma
  • nephroma, mesoblastic
differentiated thyroid carcinoma
  • papillary or follicular thyroid carcinoma
congenital fibrosarcoma
  • infantile fibrosarcoma
pediatric fibrosarcoma
  • childhood fibrosarcoma
- elite association - COSMIC cancer census association via MalaCards
Search NTRK3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

NTRK3_HUMAN
  • Note=Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations. {ECO:0000269 PubMed:25196463}.

Relevant External Links for NTRK3

Genetic Association Database (GAD)
NTRK3
Human Genome Epidemiology (HuGE) Navigator
NTRK3
Tumor Gene Database (TGDB):
NTRK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NTRK3
genes like me logo Genes that share disorders with NTRK3: view

No data available for Genatlas for NTRK3 Gene

Publications for NTRK3 Gene

  1. Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant. (PMID: 7806211) McGregor L.M. … Nelkin B.D. (Genomics 1994) 2 3 4 23 67
  2. NT-3 gene modified Schwann cells promote TrkC gene modified mesenchymal stem cells to differentiate into neuron-like cells in vitro. (PMID: 19680743) Zhang Y.Q. … Zeng Y.S. (Anat Sci Int 2010) 3 23
  3. Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis. (PMID: 20160348) Bouzas-Rodriguez J. … Mehlen P. (J. Clin. Invest. 2010) 3 23
  4. A novel point variant in NTRK3, R645C, suggests a role of this gene in the pathogenesis of Hirschsprung disease. (PMID: 19040714) FernA!ndez R.M. … Borrego S. (Ann. Hum. Genet. 2009) 3 23
  5. Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC. (PMID: 19179422) Weinkauf C. … Pereiraperrin M. (Infect. Immun. 2009) 3 23

Products for NTRK3 Gene

Sources for NTRK3 Gene

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