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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTRK3 Gene

protein-coding   GIFtS: 75
GCID: GC15M088402

Neurotrophic Tyrosine Kinase, Receptor, Type 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neurotrophic Tyrosine Kinase, Receptor, Type 31 2     NT-3 Growth Factor Receptor2
TRKC2 3 5     Tyrosine Kinase Receptor C2
GP145-TrkC2 3     Trk-C3
EC 2.7.10.13 8     Neurotrophic Tyrosine Kinase Receptor Type 33
ETS Related Protein-Neurotrophic Receptor Tyrosine Kinase Fusion Protein2     TrkC Tyrosine Kinase3
ETV6-NTRK3 Fusion2     EC 2.7.108
gp145(trkC)2     

External Ids:    HGNC: 80331   Entrez Gene: 49162   Ensembl: ENSG000001405387   OMIM: 1913165   UniProtKB: Q162883   

Export aliases for NTRK3 gene to outside databases

Previous GC identifers: GC15M084556 GC15M081649 GC15M086007 GC15M086149 GC15M086221 GC15M064532


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTRK3 Gene:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a
membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.
Signalling through this kinase leads to cell differentiation and may play a role in the development of
proprioceptive neurons that sense body position. Mutations in this gene have been associated with
medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2011)

GeneCards Summary for NTRK3 Gene: 
NTRK3 (neurotrophic tyrosine kinase, receptor, type 3) is a protein-coding gene. Diseases associated with NTRK3 include medulloblastoma, and congenital fibrosarcoma, and among its related super-pathways are Development Neurotrophin family signaling and Rac1 Pathway. GO annotations related to this gene include ephrin receptor binding and p53 binding. An important paralog of this gene is ROR1.

UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288
Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the
trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties

Gene Wiki entry for NTRK3 (TrkC receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010274.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NTRK3 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTRK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for NTRK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTRK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25   Ensembl cytogenetic band:  15q25.3   HGNC cytogenetic band: 15q24-q25

NTRK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTRK3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M088402:  view genomic region     (about GC identifiers)

Start:
88,402,982 bp from pter      End:
88,799,999 bp from pter
Size:
397,018 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288 (See protein sequence)
Recommended Name: NT-3 growth factor receptor precursor  
Size: 839 amino acids; 94428 Da
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures.
Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity)
Subcellular location: Membrane; Single-pass type I membrane protein
2 PDB 3D structures from and Proteopedia for NTRK3:
1WWC (3D)        3V5Q (3D)    
Secondary accessions: O75682 Q12827 Q16289
Alternative splicing: 4 isoforms:  Q16288-1   Q16288-2   Q16288-3   Q16288-4   

Explore the universe of human proteins at neXtProt for NTRK3: NX_Q16288

Explore proteomics data for NTRK3 at MOPED 

Post-translational modifications:

  • UniProtKB: Ligand-mediated auto-phosphorylation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16288

  • 4/32 DME Specific Peptides for NTRK3 (Q16288) (see all 32)
     YTLIAKN  CPKEVYD  RRDIVLK  VKFYGVC 

    NTRK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NTRK3 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001007157.1  NP_001012338.1  NP_001230030.1  NP_002521.2  

    ENSEMBL proteins: 
     ENSP00000377990   ENSP00000453959   ENSP00000473315   ENSP00000437773   ENSP00000453511  
     ENSP00000444673   ENSP00000473475   ENSP00000473656   ENSP00000354207   ENSP00000350356  
     ENSP00000347397   ENSP00000318328  

    Human Recombinant Protein Products for NTRK3: 
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    OriGene Purified Proteins for NTRK3
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    GenScript Custom Purified and Recombinant Proteins Services for NTRK3
    Novus Biologicals NTRK3 Proteins
    Novus Biologicals NTRK3 Lysates
    Sino Biological Recombinant Protein for NTRK3
    Sino Biological Cell Lysate for NTRK3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NTRK3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane IEA--
    GO:0016020membrane ----

    NTRK3 for ontologies           About GeneDecksing



    NTRK3 Antibody Products: 
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    Abcam antibodies for NTRK3
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    ThermoFisher Antibody for NTRK3
    LSBio Antibodies in human, mouse, rat for NTRK3 

    Assay Products for NTRK3: 
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NTRK3 
    Cloud-Clone Corp. CLIAs for NTRK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: neurotrophic tyrosine kinase, receptor, type 3 
    Neurotrophin receptor/Trk family

    5/17 InterPro protein domains (see all 17):
     IPR020446 Tyr_kin_neurotrophic_rcpt_3
     IPR017441 Protein_kinase_ATP_BS
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q16288

    ProtoNet protein and cluster: Q16288

    5 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB002011 Receptor tyrosine kinase
    IPB003599 Immunoglobulin subtype
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 protein kinase domain


    NTRK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTRK3_HUMAN, Q16288
    Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the
    trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for NTRK3:
    receptor tyrosine kinase C,linking neurotrophin 3 (NTF3),containing a CGG repeat in 5'utr,with a translocation
    t(12;15)(p13;q25) in congenital fibrosarcoma (CFS) and in congenital mesoblastic nephroma (CMN),involved in the
    survival and differentiation of nervous system and heart,and in tumour development

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI--
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0005030neurotrophin receptor activity IDA--
         
    NTRK3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NTRK3:
     Decreased focal adhesion (FA)   Increased cell number in G1, a  Increased mitotic index 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ntrk3):
     behavior/neurological  cardiovascular system  growth/size  hearing/vestibular/ear  mortality/aging 
     nervous system  no phenotypic analysis  normal  respiratory system  vision/eye 

    NTRK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NTRK3: Ntrk3tm1Par Ntrk3tm1Bbd Ntrk3tm1.1Tes

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NTRK3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NTRK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTRK3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTRK3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target NTRK3:
    hsa-mir-509-3p (MIRT004915), hsa-mir-9 (MIRT003323), hsa-mir-198 (MIRT004911), hsa-mir-128 (MIRT000340), hsa-mir-765 (MIRT000030), hsa-mir-384 (MIRT004909), hsa-mir-345 (MIRT004882), hsa-mir-617 (MIRT004881), hsa-mir-185 (MIRT005963), hsa-mir-330-3p (MIRT004910), hsa-mir-625 (MIRT004914), hsa-mir-485-3p (MIRT000045), hsa-mir-125a-5p (MIRT003755), hsa-mir-151-3p (MIRT005962)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTRK3
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate NTRK3 (see all 54):
    hsa-miR-142-5p hsa-let-7d hsa-miR-106a hsa-miR-765 hsa-miR-128 hsa-miR-3653 hsa-let-7g hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidNTRK3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of NTRK3

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    OriGene ORF clones in mouse, rat for NTRK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NTRK3 (NM_001007156)
    Sino Biological Human cDNA Clone for NTRK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTRK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTRK3
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                         Customized lentivirus expression plasmids for stable overexpression of NTRK3 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTRK3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NTRK3 About   (see all 24)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Actin-Based Motility by Rho Family GTPases0.62
    Apoptotic Pathways in Synovial Fibroblasts0.84
    ERK5 Signaling0.61
    p53 Mediated Apoptosis0.84
    eIF2 Pathway0.60
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for NTRK3
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    1 R&D Systems Pathway for NTRK3
        Akt Signaling Pathway

    5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NTRK3 (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for NTRK3
        Neuroscience

    3 Tocris Bioscience Pathways for NTRK3
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway

    2 GeneGo (Thomson Reuters) Pathways for NTRK3
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    2 BioSystems Pathways for NTRK3
        BDNF signaling pathway
    Neurotrophic factor-mediated Trk receptor signaling



    1         Kegg Pathway  (Kegg details for NTRK3):
        Neurotrophin signaling pathway


    NTRK3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NTRK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for NTRK3 (Q162882, 3 ENSP000003542074) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN1P180312, 3, ENSP000003606834MINT-6793957 I2D: score=4 STRING: ENSP00000360683
    NTF3P207833, ENSP000003972974I2D: score=3 STRING: ENSP00000397297
    PLCG1P191743, ENSP000002440074I2D: score=2 STRING: ENSP00000244007
    SHC1P293533, ENSP000004013034I2D: score=2 STRING: ENSP00000401303
    SQSTM1Q135013, ENSP000003744554I2D: score=2 STRING: ENSP00000374455
    About this table

    Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA--
    GO:0001764neuron migration IEA--
    GO:0001933negative regulation of protein phosphorylation IDA--
    GO:0006468protein phosphorylation ----
    GO:0006950response to stress ----

    NTRK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NTRK3 for compounds           About GeneDecksing

    EMD Millipore small molecules for NTRK3:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

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    2 HMDB Compounds for NTRK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 IUPHAR Ligand for NTRK3 (neurotrophic tyrosine kinase, receptor, type 3)    About this table 
    LigandTypeActionAffinityPubmed IDs
    neurotrophin-3
    NoneNone--

    10/14 Novoseek inferred chemical compound relationships for NTRK3 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 81.2 208 7657612 (5), 12210087 (3), 7536501 (2), 17942918 (2) (see all 99)
    k252a 73.3 2 1312698 (1)
    imatinib 60.5 6 19369884 (1), 16779792 (1), 15044924 (1), 12389876 (1) (see all 5)
    o-tyrosine 44.2 1 11279608 (1)
    phosphatidylinositol 16.9 4 17991742 (1), 11751416 (1), 12393643 (1), 15654360 (1)
    retinoic acid 14.3 4 11520943 (1), 10051769 (1), 16996685 (1)
    threonine 0 2 9125498 (1)
    proline 0 1 10854035 (1)
    matrigel 0 1 9786961 (1)
    aspartate 0 3 7536501 (1), 12393643 (1)

    Search CenterWatch for drugs/clinical trials and news about NTRK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NTRK3 gene (4 alternative transcripts): 
    NM_001007156.2  NM_001012338.2  NM_001243101.1  NM_002530.3  

    Unigene Cluster for NTRK3:

    Neurotrophic tyrosine kinase, receptor, type 3
    Hs.410969  [show with all ESTs]
    Unigene Representative Sequence: NM_001007156
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000394480(uc002bmh.2 uc002bme.2 uc002bmf.2 uc021sua.1)
    ENST00000557856 ENST00000558576 ENST00000542733(uc010upl.1) ENST00000558676(uc010bnh.1)
    ENST00000559680 ENST00000560201 ENST00000558306 ENST00000540489 ENST00000537300
    ENST00000560739 ENST00000560017 ENST00000557897 ENST00000559764 ENST00000559188
    ENST00000559067 ENST00000360948 ENST00000357724

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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTRK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTRK3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTRK3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTRK3

    Additional mRNA sequence: 

    AF052184.1 AF058389.1 AF058390.1 AF125808.1 AF125809.1 AK297160.1 AK302504.1 AK309695.1 
    AK313646.1 AY065844.1 BC013693.1 BC128249.1 BT007291.1 DQ323596.1 S76475.1 S76476.1 
    U05012.1 

    11 DOTS entries:

    DT.86854416  DT.92421160  DT.102828288  DT.100755429  DT.92421154  DT.75137184  DT.86854418  DT.95348504 
    DT.451766  DT.100703241  DT.92421158 

    24/86 AceView cDNA sequences (see all 86):

    AI140305 AF058389 AY065844 AW013956 CK903552 AA371187 BI966722 AW090568 
    BE047716 BP347900 CD723536 BF512741 AI953850 CA391718 BM887782 CD370531 
    AF058390 AI368629 BC013693 AA700335 AF052184 CD172131 AW270931 BI962878 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NTRK3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
    SP1:                                                                                      -     -     -           -     -                       -               
    SP2:                                                                                      -     -     -           -     -                                       
    SP3:                                                                                      -     -     -                                                         
    SP4:                                                                    -                 -     -     -                                                         
    SP5:                                                                                                                                                            

    ExUns: 24b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for NTRK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTRK3 expression in normal human tissues (normalized intensities)      NTRK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGGCTGTT
    NTRK3 Expression
    About this image


    NTRK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/25 selected tissues (see all 25) fully expand
     
     Brain (Nervous System)    fully expand to see all 23 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 5 entries
             Superior Cervical Ganglion   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Atrioventricular Node
             heart/atrium   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             spinal/ganglion/dorsal root ganglion   

    See NTRK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTRK3

    SOURCE GeneReport for Unigene cluster: Hs.410969

    UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288
    Tissue specificity: Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in
    adult brain than in fetal brain

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NTRK3 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntrk31 , 5 neurotrophic tyrosine kinase, receptor, type 31, 5 91.03(n)1
    97.21(a)1
      7 (44.01 cM)5
    182131  NM_008746.51  NP_032772.31 
     781923625 
    chicken
    (Gallus gallus)
    Aves NTRK31 neurotrophic tyrosine kinase, receptor, type 3 82.12(n)
    88.92(a)
      396081  NM_205169.1  NP_990500.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    90(a)
    71(a)
    1 ↔ many
    1 ↔ many
    GL343641.1(57495-139618)
    GL343389.1(474956-985764)
    zebrafish
    (Danio rerio)
    Actinopterygii ntrk12 neurotrophic tyrosine kinase, receptor, type 1 76.81(n)   30546  S78348.1 


    ENSEMBL Gene Tree for NTRK3 (if available)
    TreeFam Gene Tree for NTRK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTRK3 gene
    ROR12  INSR2  ROS12  NTRK22  LTK2  IGF1R2  PTK72  DDR12  
    INSRR2  ROR22  DDR22  MUSK2  ALK2  NTRK12  
    18/35 SIMAP similar genes for NTRK3 using alignment to 11 protein entries:     NTRK3_HUMAN (see all proteins) (see all similar genes):
    EPHA4    RET    BTK    DDR1    ABL1    FLT4
    TYK2    tec    TXK    NTRK2    EPHA2    NTRK1
    MET    BTK kinase deficient isoform 6    FRK    FGFR1    PTK7    FGR

    NTRK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8601 SNPs in NTRK3 are shown (see all 8601)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0414754
    A lung adenocarcinoma sample4--see VAR_0414752 H Y mis40--------
    VAR_0465244
    A lung carcinoma sample4--see VAR_0465242 Y F mis40--------
    VAR_0467704
    A lung large cell carcinoma sample4--see VAR_0467702 R F mis40--------
    VAR_0465214
    A lung carcinoma sample4--see VAR_0465212 A S mis40--------
    VAR_0465234
    A lung carcinoma sample4--see VAR_0465232 R P mis40--------
    VAR_0414714
    A gastric adenocarcinoma sample4--see VAR_0414712 T R mis40--------
    VAR_0414734
    A lung adenocarcinoma sample4--see VAR_0414732 V L mis40--------
    VAR_0414744
    A lung adenocarcinoma sample4--see VAR_0414742 L Q mis40--------
    VAR_0465224
    A lung carcinoma sample4--see VAR_0465222 W C mis40--------
    rs341471131,2
    C--64545442(+) TTTCC-/ATTT  
            
    ATTTA
    3 -- int10--------

    HapMap Linkage Disequilibrium report for NTRK3 (88402982 - 88652982 bp, first 250kb of NTRK3)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NTRK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749991CNV Deletion23290073
    esv2608620CNV Deletion19546169
    esv271976CNV Insertion20981092
    nsv94255CNV Loss16902084
    nsv904476CNV Gain21882294
    nsv904475CNV Gain21882294
    nsv827427CNV Gain20364138
    nsv527970CNV Gain19592680


    Human Gene Mutation Database (HGMD): NTRK3
    4 SABiosciences Cancer Mutation PCR Assays for NTRK3:
    Cosmic IdAA Change
    21232p.L336Q
    12890p.H677Y
    21214p.V307L
    79006p.E556*
    SeqTarget long-range PCR primers for resequencing NTRK3
    DNA2.0 Custom Variant and Variant Library Synthesis for NTRK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191316    OMIM disorders: --

    20/75 diseases for NTRK3 (see all 75):    About MalaCards
    medulloblastoma    congenital fibrosarcoma    fibrosarcoma    mesoblastic nephroma
    congenital mesoblastic nephroma    mastocytosis    polymorphous low-grade adenocarcinoma    perivascular epithelioid cell tumor
    thymic epithelial tumor    gastrointestinal stromal tumor    pancreatic cancer    phyllode tumor
    childhood medulloblastoma    systemic mastocytosis    hirschsprung's disease    ganglioneuroma
    anxiety disorder    tetralogy of fallot    phaeochromocytoma    tuberous sclerosis complex

    2 diseases from the University of Copenhagen DISEASES database for NTRK3:
    Fibrosarcoma     Congenital mesoblastic nephroma

    NTRK3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/48 Novoseek inferred disease relationships for NTRK3 gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    medulloblastoma 74.8 21 16077909 (3), 9560008 (2), 15198123 (2), 8817419 (1) (see all 14)
    leukemia mast cell 69.8 3 7536501 (1), 9209403 (1)
    medulloblastoma desmoplastic 64.8 1 12471454 (1)
    gastrointestinal stromal tumor 62.9 10 12738950 (1), 16101174 (1), 19369884 (1), 11914627 (1) (see all 10)
    mastocytoma 45 6 7536501 (2), 7513208 (1), 9209403 (1)
    tumors 39 56 10994550 (2), 17942918 (2), 7604872 (2), 8552397 (2) (see all 36)
    sarcoma spindle cell 37.7 1 14668342 (1)
    pediatric solid tumor 36.3 1 11751416 (1)
    fibrosarcoma 36.1 4 11751416 (1), 12210087 (1), 9778053 (1)
    mastocytosis 36.1 2 11914627 (1), 12393643 (1)

    Genetic Association Database (GAD): NTRK3
    Human Genome Epidemiology (HuGE) Navigator: NTRK3 (21 documents)
    Tumor Gene Database (TGDB): NTRK3

    Export disorders for NTRK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTRK3 gene, integrated from 9 sources (see all 445):
    (articles sorted by number of sources associating them with NTRK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant. (PubMed id 7806211)1, 2, 3, 9 McGregor L.M.... Nelkin B.D. (1994)
    2. Association of the neurotrophic tyrosine kinase receptor 3 (NTRK3) gene and childhood-onset mood disorders. (PubMed id 18347002)1, 4, 9 Feng Y....Barr C.L. (2008)
    3. Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. (PubMed id 19370765)1, 4, 9 MuiA+os-Gimeno M....Espinosa-Parrilla Y. (2009)
    4. A novel point variant in NTRK3, R645C, suggests a role of this gene in the pathogenesis of Hirschsprung disease. (PubMed id 19040714)1, 4, 9 FernA!ndez R.M....Borrego S. (2009)
    5. Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia. (PubMed id 19344762)1, 4, 9 Otnaess M.K....Andreassen O.A. (2009)
    6. Genetic susceptibility to obsessive-compulsive hoarding: the contribution of neurotrophic tyrosine kinase receptor type 3 (NTRK3) gene. (PubMed id 18616610)1, 4, 9 Alonso P....Estivill X. (2008)
    7. Genomic characterization of the human trkC gene. (PubMed id 9778053)1, 2, 9 Ichaso N.... Gonzalez-Sarmiento R. (1998)
    8. Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. (PubMed id 18293376)1, 2, 9 Marchetti A.... Buttitta F. (2008)
    9. Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. (PubMed id 18428117)1, 4, 9 Conner A.C....Thome J. (2008)
    10. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. (PubMed id 7823156)1, 2, 9 Shelton D.L.... Levinson A.D. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4916 HGNC: 8033 AceView: NTRK3 Ensembl:ENSG00000140538 euGenes: HUgn4916
    ECgene: NTRK3 Kegg: 4916 H-InvDB: NTRK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTRK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NTRK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NTRK3 gene:
    Search GeneIP for patents involving NTRK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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