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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NTRK3 Gene

protein-coding GIFtS: 74
GCID: GC15M088402

neurotrophic tyrosine kinase, receptor, type 3

Explore 77 diseases affiliated with
NTRK3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neurotrophic Tyrosine Kinase, Receptor, Type 3¹ ²		NT-3 Growth Factor Receptor²
TRKC¹ ² ³ ⁵		Tyrosine Kinase Receptor C²
GP145-TrkC² ³		Trk-C³
EC 2.7.10.1³ ⁸		Neurotrophic Tyrosine Kinase Receptor Type 3³
ETS Related Protein-Neurotrophic Receptor Tyrosine Kinase Fusion Protein²		TrkC Tyrosine Kinase³
ETV6-NTRK3 Fusion²		EC 2.7.10⁸
Gp145(TrkC)¹

External Ids:	HGNC: 8033¹	Entrez Gene: 4916²	Ensembl: ENSG00000140538⁷	OMIM: 191316⁵	UniProtKB: Q16288³

Export aliases for NTRK3 gene to outside databases

Previous GC identifers: GC15M084556 GC15M081649 GC15M086007 GC15M086149 GC15M086221 GC15M064532

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTRK3:

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound

receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through

this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense

body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and

other cancers. Several transcript variants encoding different isoforms have been found for this gene. (provided by

RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288

Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk

receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties

Gene Wiki entry for NTRK3 (TrkC receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NTRK3 gene promoter:
ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NTRK3 promoter sequence

Search SABiosciences Chromatin IP Primers for NTRK3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTRK3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25 Ensembl cytogenetic band: 15q25.3 HGNC cytogenetic band: 15q24-q25

NTRK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTRK3 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M088402: view genomic region (about GC identifiers)

Start:	88,402,982 bp from pter	End:	88,799,999 bp from pter
Size:	397,018 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288 (See protein sequence)

Recommended Name: NT-3 growth factor receptor precursor

Size: 839 amino acids; 94428 Da

Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds

SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

2 PDB 3D structures from and Proteopedia for NTRK3:

1WWC (3D)

3V5Q (3D)

Secondary accessions: O75682 Q12827 Q16289

Alternative splicing: 4 isoforms: Q16288-1 Q16288-2 Q16288-3 Q16288-4

Explore the universe of human proteins at neXtProt for NTRK3: NX_Q16288

Post-translational modifications:

Ligand-mediated auto-phosphorylation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q16288

4/32 DME Specific Peptides for NTRK3 (Q16288) (see all 32)

YTLIAKN

CPKEVYD

RLNIKEI

TCNGSGS

NTRK3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001007157.1 NP_001012338.1 NP_001230030.1 NP_002521.2

ENSEMBL proteins:

ENSP00000377990 ENSP00000453959 ENSP00000437773 ENSP00000453511 ENSP00000444673

ENSP00000453624 ENSP00000354207 ENSP00000350356 ENSP00000347397 ENSP00000318328

Human Recombinant Protein Products for NTRK3:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for NTRK3 (TrkC)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 3): NTRK3 OriGene Protein Over-expression Lysate (see all 2): NTRK3 OriGene Custom Protein Services for NTRK3
	GenScript Custom Purified and Recombinant Proteins Services for NTRK3
	Novus Biologicals NTRK3 Proteins Novus Biologicals NTRK3 Lysates
	Sino Biological Recombinant Protein for NTRK3
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NTRK3

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	--	--
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	--	--
GO:0005887	integral to plasma membrane	IEA	--

NTRK3 for ontologies About GeneDecksing

NTRK3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NTRK3
	R&D Systems Antibodies for NTRK3 (TrkC)
	Cell Signaling Technology (CST) Antibodies for NTRK3 (TrkC)
	OriGene Antibodies (see all 4): NTRK3 OriGene Custom Antibody Services for NTRK3
	GenScript Custom Superior Antibodies Services for NTRK3
	Novus Biologicals NTRK3 Antibodies
	Abcam antibodies for NTRK3
	Uscn Antibodies for NTRK3
	ThermoFisher Antibody for NTRK3

Assay Products for NTRK3:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for NTRK3 (TrkC) (see all)
	GenScript Custom Assay Services for NTRK3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NTRK3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NTRK3 for domains About GeneDecksing

5/17 InterPro domains/families (see all 17):

IPR020446 Tyr_kin_neurotrophic_rcpt_3

IPR017441 Protein_kinase_ATP_BS

IPR000483 Cys-rich_flank_reg_C

IPR001611 Leu-rich_rpt

IPR013098 Ig_I-set

Graphical View of Domain Structure for InterPro Entry Q16288

ProtoNet protein and cluster: Q16288

5 Blocks protein families:

IPB000372 Cysteine-rich flanking region

IPB000483 Cysteine-rich flanking region

IPB002011 Receptor tyrosine kinase

IPB003599 Immunoglobulin subtype

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 2 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRCT domain

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NTRK3_HUMAN, Q16288

Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk

receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Genatlas biochemistry entry for NTRK3:

receptor tyrosine kinase C,linking neurotrophin 3 (NTF3),containing a CGG repeat in 5'utr,with a translocation

t(12;15)(p13;q25) in congenital fibrosarcoma (CFS) and in congenital mesoblastic nephroma (CMN),involved in the

survival and differentiation of nervous system and heart,and in tumour development

Enzyme Numbers (IUBMB): EC 2.7.10.1¹ ² EC 2.7.10²

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002039	p53 binding	IPI	--
GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	--
GO:0005030	neurotrophin receptor activity	IDA	--
GO:0005515	protein binding	--	--
GO:0005524	ATP binding	IEA	--

NTRK3 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for NTRK3:

Decreased focal adhesion (FA)

Increased cell number in G1, a

Increased mitotic index

10 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Ntrk3):

behavior/neurological	cardiovascular system	growth/size	hearing/vestibular/ear	mortality/aging
nervous system	no phenotypic analysis	normal	respiratory system	vision/eye

NTRK3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for NTRK3: Ntrk3^tm1Par Ntrk3^tm1Bbd Ntrk3^tm1.1Tes

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NTRK3

miRNA Products:		miRTarBase miRNAs that target NTRK3: hsa-mir-509-3p (MIRT004915), hsa-mir-9 (MIRT003323), hsa-mir-198 (MIRT004911), hsa-mir-128 (MIRT000340), hsa-mir-765 (MIRT000030), hsa-mir-384 (MIRT004909), hsa-mir-345 (MIRT004882), hsa-mir-617 (MIRT004881), hsa-mir-185 (MIRT005963), hsa-mir-330-3p (MIRT004910), hsa-mir-625 (MIRT004914), hsa-mir-485-3p (MIRT000045), hsa-mir-125a-5p (MIRT003755), hsa-mir-151-3p (MIRT005962)

		OriGene 3'-UTR Clone (see all 3): NTRK3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTRK3
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate NTRK3 (see all 54):
		hsa-miR-142-5p hsa-let-7d hsa-miR-106a hsa-miR-765 hsa-miR-128 hsa-miR-3653 hsa-let-7g hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: NTRK3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTRK3 (see all 7) OriGene shRNA RFP: NTRK3 OriGene siRNA: NTRK3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTRK3
		Sirion Biotech Custom design and validation of potent shRNA sequences against NTRK3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NTRK3
			Sirion Biotech Customized adenovirus for overexpression of NTRK3 Sirion Biotech Customized adenovirus for potent knockdown of NTRK3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTRK3 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTRK3 (see all 6) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): NTRK3 (NM_001007156)
		Sino Biological Human cDNA Clone for NTRK3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTRK3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTRK3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NTRK3
		Search LifeMap BioReagents cell lines for NTRK3
		Sirion Biotech Customized stable knockdown cell line services for NTRK3 Sirion Biotech Customized inducible knockdown cell line services for NTRK3 Sirion Biotech Customized stable overexpressing cell line services for NTRK3 Sirion Biotech Customized inducible overexpressing cell line services for NTRK3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTRK3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/13 pathways (see all 13)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58	P2Y Receptor Signaling	0.38

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Apoptosis Pathway

	Apoptosis Pathway	1.00			Akt Pathway	0.39
	NF-kappaB Pathway	0.45

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for NTRK3

	Development Neurotrophin family signaling
	Development MAG-dependent inhibition of neurite outgrowth

5/55 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NTRK3 (see all 55)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

1 Cell Signaling Technology (CST) Pathway for NTRK3

Neuroscience

3 Tocris Bioscience Pathways for NTRK3

	Akt Pathway
	Apoptosis Pathway
	NF-kappaB Pathway

2 GeneGo (Thomson Reuters) Pathways for NTRK3

	Development Neurotrophin family signaling
	Development MAG-dependent inhibition of neurite outgrowth

1 BioSystems Pathway for NTRK3

Neurotrophic factor-mediated Trk receptor signaling

1 Kegg Pathway (Kegg details for NTRK3):

Neurotrophin signaling pathway

NTRK3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NTRK3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/33 Interacting proteins for NTRK3 (Q16288^{2, 3} ENSP00000354207⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 33)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PTPN1	P18031²^,³, ENSP00000360683⁴	MINT-6793957 I2D: score=4 STRING: ENSP00000360683
NTF3	P20783³, ENSP00000397297⁴	I2D: score=3 STRING: ENSP00000397297
PLCG1	P19174³, ENSP00000244007⁴	I2D: score=2 STRING: ENSP00000244007
SHC1	P29353³, ENSP00000401303⁴	I2D: score=2 STRING: ENSP00000401303
SQSTM1	Q13501³, ENSP00000374455⁴	I2D: score=2 STRING: ENSP00000374455

About this table

Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IDA	--
GO:0001764	neuron migration	IEA	--
GO:0001933	negative regulation of protein phosphorylation	IDA	--
GO:0006950	response to stress	--	--
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IDA	--

NTRK3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NTRK3 for compounds About GeneDecksing

EMD Millipore small molecules for NTRK3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NTRK3

2 HMDB Compounds for NTRK3 About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--

10/14 Novoseek chemical compound relationships for NTRK3 gene (see all 14) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	81.2	208	7657612 (5), 12210087 (3), 7536501 (2), 17942918 (2) (see all 99)
k252a	73.3	2	1312698 (1)
imatinib	60.5	6	19369884 (1), 16779792 (1), 15044924 (1), 12389876 (1) (see all 5)
o-tyrosine	44.2	1	11279608 (1)
phosphatidylinositol	16.9	4	17991742 (1), 11751416 (1), 12393643 (1), 15654360 (1)
retinoic acid	14.3	4	11520943 (1), 10051769 (1), 16996685 (1)
threonine	0	2	9125498 (1)
proline	0	1	10854035 (1)
matrigel	0	1	9786961 (1)
aspartate	0	3	7536501 (1), 12393643 (1)

Search CenterWatch for drugs/clinical trials and news about NTRK3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NTRK3 gene (4 alternative transcripts):

NM_001007156.2 NM_001012338.2 NM_001243101.1 NM_002530.3

Unigene Cluster for NTRK3:

Neurotrophic tyrosine kinase, receptor, type 3

Hs.410969 [show with all ESTs]

Unigene Representative Sequence: NM_001007156

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000394480(uc002bmh.2 uc002bme.2 uc002bmf.2 uc021sua.1)

ENST00000557856 ENST00000558576 ENST00000542733(uc010upl.1) ENST00000558676(uc010bnh.1)

ENST00000559680 ENST00000560201 ENST00000558306 ENST00000540489 ENST00000537300

ENST00000560739 ENST00000560017 ENST00000557897 ENST00000559764 ENST00000559188

ENST00000560988 ENST00000559067 ENST00000360948

miRNA Products:		OriGene 3'-UTR Clone (see all 3): NTRK3 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTRK3
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate NTRK3 (see all 54):
		hsa-miR-142-5p hsa-let-7d hsa-miR-106a hsa-miR-765 hsa-miR-128 hsa-miR-3653 hsa-let-7g hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: NTRK3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTRK3 (see all 7) OriGene shRNA RFP: NTRK3 OriGene siRNA: NTRK3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTRK3
		Sirion Biotech Custom design and validation of potent shRNA sequences against NTRK3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTRK3 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTRK3 (see all 6) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): NTRK3 (NM_001007156)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTRK3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTRK3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTRK3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NTRK3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTRK3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTRK3

Additional cDNA sequence:

AF052184.1 AF058389.1 AF058390.1 AF125808.1 AF125809.1 AK297160.1 AK302504.1 AK309695.1

AK313646.1 AY065844.1 BC013693.1 BC128249.1 BT007291.1 DQ323596.1 S76475.1 S76476.1

U05012.1

11 DOTS entries:

DT.86854416 DT.92421160 DT.102828288 DT.100755429 DT.92421154 DT.75137184 DT.86854418 DT.95348504

DT.451766 DT.100703241 DT.92421158

24/86 AceView cDNA sequences (see all 86):

AI368629 BP347900 CD172131 BF512741 CD370531 AW090568 AF052184 AA700335

AF058390 AI140305 AF058389 AI953850 CK903552 AW013956 CA391718 AY065844

BI966722 AA371187 BM887782 CD723536 BE047716 BC013693 BI962878 NM_002530

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NTRK3 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21	^	22	^	23	^	24a	·
SP1:																													-		-		-				-		-								-
SP2:																													-		-		-				-		-
SP3:																													-		-		-
SP4:																							-						-		-		-
SP5:

ExUns:	24b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for NTRK3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NTRK3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGGCTGTT

About this image

NTRK3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

8 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Reproductive System

Interscapular Brown Adipose Depot

Adipose

Thoracic Perivascular Adipose

Adipose

Brain

Brain

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See NTRK3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NTRK3

SOURCE GeneReport for Unigene cluster: Hs.410969

UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288

Tissue specificity: Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult

brain than in fetal brain

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for NTRK3 gene from 4/14 species (see all 14) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NTRK3¹	neurotrophic tyrosine kinase, receptor, type 3	82.12(n) 88.92(a)		396081 NM_205169.1 NP_990500.1
lizard (Anolis carolinensis)	Reptilia	--	--	98(a)	1 ↔ 1	GL343641.1(57497-139607)
zebrafish (Danio rerio)	Actinopterygii	ntrk1²	neurotrophic tyrosine kinase, receptor, type 1	76.81(n)		30546 S78348.1
honey bee (Apis mellifera)	Insecta	--	--	25(a)	1 → many	GroupUn.109(136008-146827)

ENSEMBL Gene Tree for NTRK3 (if available)
TreeFam Gene Tree for NTRK3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NTRK3 gene

INSR² ROR1² ROS1² LTK² NTRK2² IGF1R² DDR1² ROR2²

INSRR² DDR2² MUSK² ALK² NTRK1²

18/33 SIMAP similar genes for NTRK3 using alignment to 9 protein entries: NTRK3_HUMAN (see all proteins) (see all similar genes):

EPHA4 BTK FLT4 tec TXK NTRK2

DDR1 EPHA2 NTRK1 MET ABL1 BTK kinase deficient isoform 6

FRK PTK7 FGR BTK kinase deficient isoform 2 AURKC DKFZp434L0319

NTRK3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77623785^1,2	F	--	64531933(+)	`AGCAGC/TGACTG`	3	--	ds500¹		1		EA	120
rs28707236^1,2	C,F	--	64532320(+)	`ATGTTC/TGCTTC`	3	--	ut3¹		1		WA	118
rs1046440^1,2	C	--	64532334(-)	`TTCCAT/GCCTTG`	3	--	ut3¹ ese³		2		NA	4
rs112494064^1,2	F	--	64532362(+)	`GGGAGG/ATGTGA`	3	--	ut3¹		2		CSA	4
rs113691188^1,2	F	--	64532393(+)	`CAGAGG/TATGAA`	3	--	ut3¹		2		CSA	4
rs78821883^1,2	C	--	64532496(+)	`GTTCAA/CCCGCT`	6	V L	mis¹		0	--	--	--	--
rs78443344^1,2		--	64532705(+)	`TTCTAG/TGCAGA`	3	--	int¹		0	--	--	--	--
rs78975701^1,2	F	--	64532714(+)	`GAGCCG/AAGGCT`	3	--	int¹		1		EA	120
rs112578820^1,2		--	64532718(+)	`CGAGGC/TTCTCA`	3	--	int¹		1		CSA	2
rs77500422^1,2		--	64533020(+)	`AAACTG/CCCATG`	3	--	int¹		3		CSA WA EA	240

HapMap Linkage Disequilibrium report for NTRK3 (88402982 - 88652982 bp, first 250kb of NTRK3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for NTRK3
3 CNVs: 5802 102155 87828
4 Indels: 87830 77060 87829 77061
Human Gene Mutation Database (HGMD): NTRK3

4 SABiosciences Cancer Mutation PCR Assays for NTRK3:

Cosmic Id	AA Change
21232	p.L336Q
12890	p.H677Y
21214	p.V307L
79006	p.E556*

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NTRK3

DNA2.0 Custom Variant and Variant Library Synthesis for NTRK3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NTRK3 for disorders           About GeneDecksing

OMIM gene information: 191316    OMIM disorders: --

20/77 diseases for NTRK3 (see all 77):    About MalaCards

medulloblastoma polymorphous low-grade adenocarcinoma breast carcinoma congenital mesoblastic nephroma

carcinoma attention deficit hyperactivity disorder perivascular epithelioid cell tumor mesoblastic nephroma

gastrointestinal stromal tumor primitive neuroectodermal tumor soft tissue sarcoma thymic epithelial tumor

mastocytosis premature ovarian failure myeloproliferative disorder myeloid leukemia

neuroectodermal tumors hirschsprung's disease tetralogy of fallot cutaneous malignant melanoma

2 diseases from the University of Copenhagen DISEASES database for NTRK3:

Fibrosarcoma Congenital mesoblastic nephroma

10/48 Novoseek disease relationships for NTRK3 gene (see all 48) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
medulloblastoma	74.8	21	16077909 (3), 9560008 (2), 15198123 (2), 8817419 (1) (see all 14)
leukemia mast cell	69.8	3	7536501 (1), 9209403 (1)
medulloblastoma desmoplastic	64.8	1	12471454 (1)
gastrointestinal stromal tumor	62.9	10	12738950 (1), 16101174 (1), 19369884 (1), 11914627 (1) (see all 10)
mastocytoma	45	6	7536501 (2), 7513208 (1), 9209403 (1)
tumors	39	56	10994550 (2), 17942918 (2), 7604872 (2), 8552397 (2) (see all 36)
sarcoma spindle cell	37.7	1	14668342 (1)
pediatric solid tumor	36.3	1	11751416 (1)
fibrosarcoma	36.1	4	11751416 (1), 12210087 (1), 9778053 (1)
mastocytosis	36.1	2	11914627 (1), 12393643 (1)

Genetic Association Database (GAD): NTRK3
Human Genome Epidemiology (HuGE) Navigator: NTRK3 (21 documents)
Tumor Gene Database (TGDB): NTRK3

Export disorders for NTRK3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NTRK3 gene, integrated from 9 sources (see all 438):
(articles sorted by number of sources associating them with NTRK3)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant. (PubMed id 7806211)^{1, 2, 3, 9} McGregor L.M.... Nelkin B.D. (1994)
Genomic characterization of the human trkC gene. (PubMed id 9778053)^{1, 2, 9} Ichaso N.... Gonzalez-Sarmiento R. (1998)
Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. (PubMed id 18293376)^{1, 2, 9} Marchetti A.... Buttitta F. (2008)
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. (PubMed id 7823156)^{1, 2, 9} Shelton D.L.... Levinson A.D. (1995)
Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PubMed id 15167446)^{1, 4} Iwai N....Shioji K. (2004)
5' UTR-region SNP in the NTRK3 gene is associated with panic disorder. (PubMed id 12399943)^{1, 4} Armengol L....Estivill X. (2002)
Gene expression of TrkC (NTRK3) in human soft tissue tumours. (PubMed id 12210087)^{1, 9} Hisaoka M....Hashimoto H. (2002)
Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling. (PubMed id 7657612)^{1, 9} Guiton M....Tavare J.M. (1995)
Decreased expression of neurotrophic tyrosine receptor kinase 3 is associated with the outflow tract defect of human tetralogy of Fallot. (PubMed id 19187638)^{1, 9} Kong B....LA1 X.D. (2009)
Association of the neurotrophic tyrosine kinase receptor 3 (NTRK3) gene and childhood-onset mood disorders. (PubMed id 18347002)^{1, 9} Feng Y....Barr C.L. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4916	HGNC: 8033	AceView: NTRK3	Ensembl:ENSG00000140538	euGenes: HUgn4916
ECgene: NTRK3	Kegg: 4916	H-InvDB: NTRK3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NTRK3	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for NTRK3	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for NTRK3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NTRK3 gene:
Search GeneIP for patents involving NTRK3

GeneCards and IP:
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neurotrophic tyrosine kinase, receptor, type 3

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NTRK3 Gene

neurotrophic tyrosine kinase, receptor, type 3

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