Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NTRK3 Gene

Aliases for NTRK3 Gene

  • Neurotrophic Tyrosine Kinase, Receptor, Type 3 2 3
  • TRKC 3 4 6
  • EC 4 63
  • GP145-TrkC 3 4
  • ETS Related Protein-Neurotrophic Receptor Tyrosine Kinase Fusion Protein 3
  • Neurotrophic Tyrosine Kinase Receptor Type 3 4
  • NT-3 Growth Factor Receptor 3
  • Tyrosine Kinase Receptor C 3
  • TrkC Tyrosine Kinase 4
  • ETV6-NTRK3 Fusion 3
  • Gp145(TrkC) 3
  • EC 2.7.10 63
  • Trk-C 4

External Ids for NTRK3 Gene

Previous GeneCards Identifiers for NTRK3 Gene

  • GC15M084556
  • GC15M081649
  • GC15M086007
  • GC15M086149
  • GC15M086221
  • GC15M088402
  • GC15M064532
  • GC15M088418

Summaries for NTRK3 Gene

Entrez Gene Summary for NTRK3 Gene

  • This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for NTRK3 Gene

NTRK3 (Neurotrophic Tyrosine Kinase, Receptor, Type 3) is a Protein Coding gene. Diseases associated with NTRK3 include fibrosarcoma and congenital mesoblastic nephroma. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include p53 binding and ephrin receptor binding. An important paralog of this gene is ALK.

UniProtKB/Swiss-Prot for NTRK3 Gene

  • Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties

Gene Wiki entry for NTRK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTRK3 Gene

Genomics for NTRK3 Gene

Regulatory Elements for NTRK3 Gene

Transcription factor binding sites by QIAGEN in the NTRK3 gene promoter:

Genomic Location for NTRK3 Gene

87,859,751 bp from pter
88,256,768 bp from pter
397,018 bases
Minus strand

Genomic View for NTRK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTRK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTRK3 Gene

Proteins for NTRK3 Gene

  • Protein details for NTRK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NT-3 growth factor receptor
    Protein Accession:
    Secondary Accessions:
    • B7Z4C5
    • E9PG56
    • H0YND1
    • O75682
    • Q12827
    • Q16289

    Protein attributes for NTRK3 Gene

    839 amino acids
    Molecular mass:
    94428 Da
    Quaternary structure:
    • Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NTRK3 Gene

    Alternative splice isoforms for NTRK3 Gene


neXtProt entry for NTRK3 Gene

Proteomics data for NTRK3 Gene at MOPED

Post-translational modifications for NTRK3 Gene

  • Ligand-mediated auto-phosphorylation
  • Glycosylation at Asn72, Asn79, Asn133, Asn163, Asn203, Asn218, Asn232, Asn259, Asn267, Asn272, Asn294, Asn375, and Asn388
  • Modification sites at PhosphoSitePlus

Domains for NTRK3 Gene

Gene Families for NTRK3 Gene

  • ISET :Immunoglobulin superfamily / I-set domain containing

Graphical View of Domain Structure for InterPro Entry



  • Q16288
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 LRRCT domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
  • Contains 2 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with NTRK3: view

Function for NTRK3 Gene

Molecular function for NTRK3 Gene

GENATLAS Biochemistry: receptor tyrosine kinase C,linking neurotrophin 3 (NTF3),containing a CGG repeat in 5utr,with a translocation t(12;15)(p13;q25) in congenital fibrosarcoma (CFS) and in congenital mesoblastic nephroma (CMN),involved in the survival and differentiation of nervous system and heart,and in tumour development
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties

Enzyme Numbers (IUBMB) for NTRK3 Gene

Gene Ontology (GO) - Molecular Function for NTRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 23027130
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA --
GO:0005030 neurotrophin receptor activity IDA 23027130
genes like me logo Genes that share ontologies with NTRK3: view
genes like me logo Genes that share phenotypes with NTRK3: view

Animal Models for NTRK3 Gene

MGI Knock Outs for NTRK3:

No data available for Transcription Factor Targeting and HOMER Transcription for NTRK3 Gene

Localization for NTRK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTRK3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for NTRK3 Gene COMPARTMENTS Subcellular localization image for NTRK3 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NTRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with NTRK3: view

Pathways for NTRK3 Gene

genes like me logo Genes that share pathways with NTRK3: view

Pathways by source for NTRK3 Gene

1 Cell Signaling Technology pathway for NTRK3 Gene
1 KEGG pathway for NTRK3 Gene
1 R&D Systems pathway for NTRK3 Gene
3 Tocris pathways for NTRK3 Gene

Gene Ontology (GO) - Biological Process for NTRK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 23027130
GO:0001764 neuron migration IEA --
GO:0001933 negative regulation of protein phosphorylation IDA 23027130
GO:0006468 protein phosphorylation --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA 23027130
genes like me logo Genes that share ontologies with NTRK3: view

Compounds for NTRK3 Gene

(2) HMDB Compounds for NTRK3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure

(1) IUPHAR Ligand for NTRK3 Gene

Ligand Type Action Affinity Pubmed IDs
neurotrophin-3 None None

(14) Novoseek inferred chemical compound relationships for NTRK3 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 81.2 125
k252a 73.3 1
imatinib 60.5 5
o-tyrosine 44.2 1
phosphatidylinositol 16.9 4
genes like me logo Genes that share compounds with NTRK3: view

Transcripts for NTRK3 Gene

Unigene Clusters for NTRK3 Gene

Neurotrophic tyrosine kinase, receptor, type 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTRK3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -

ExUns: 24b

Relevant External Links for NTRK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NTRK3 Gene

mRNA expression in normal human tissues for NTRK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTRK3 Gene

This gene is overexpressed in Artery - Tibial (6.0) and Artery - Coronary (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NTRK3 Gene

SOURCE GeneReport for Unigene cluster for NTRK3 Gene Hs.410969

mRNA Expression by UniProt/SwissProt for NTRK3 Gene

Tissue specificity: Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain
genes like me logo Genes that share expressions with NTRK3: view

Orthologs for NTRK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTRK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NTRK3 35
  • 99.39 (n)
  • 99.76 (a)
NTRK3 36
  • 100 (a)
(Bos Taurus)
Mammalia -- 36
  • 97 (a)
NTRK3 35
  • 92.98 (n)
  • 98.78 (a)
NTRK3 36
  • 97 (a)
(Canis familiaris)
Mammalia NTRK3 35
  • 91.45 (n)
  • 97.98 (a)
NTRK3 36
  • 98 (a)
(Mus musculus)
Mammalia Ntrk3 35
  • 91.03 (n)
  • 97.21 (a)
Ntrk3 16
Ntrk3 36
  • 97 (a)
(Monodelphis domestica)
Mammalia NTRK3 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
-- 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Ntrk3 35
  • 90.98 (n)
  • 97.26 (a)
(Gallus gallus)
Aves NTRK3 35
  • 82.12 (n)
  • 88.92 (a)
NTRK3 36
  • 86 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
-- 36
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ntrk3 35
  • 75.09 (n)
  • 85.18 (a)
(Danio rerio)
Actinopterygii ntrk1 35
ntrk3a 35
  • 71.42 (n)
  • 75.92 (a)
ntrk3a 36
  • 78 (a)
ntrk3b 36
  • 77 (a)
(Caenorhabditis elegans)
Secernentea trk-1 36
  • 22 (a)
Y69E1A.3 37
  • 33 (a)
Species with no ortholog for NTRK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTRK3 Gene

Gene Tree for NTRK3 (if available)
Gene Tree for NTRK3 (if available)

Paralogs for NTRK3 Gene

Paralogs for NTRK3 Gene

genes like me logo Genes that share paralogs with NTRK3: view

Variants for NTRK3 Gene

Sequence variations from dbSNP and Humsavar for NTRK3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs187828 -- 88,093,644(+) ATGAA(A/G)AACAT intron-variant
rs187829 -- 88,093,878(+) CATGT(G/T)GTTAT intron-variant
rs189716 -- 88,030,971(-) cttca(A/G)aacga intron-variant
rs190537 -- 88,093,603(+) CCATA(G/T)CATAC intron-variant
rs190538 -- 88,031,355(-) GTTTC(A/C)TAGGG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for NTRK3 Gene

Variant ID Type Subtype PubMed ID
nsv94255 CNV Loss 16902084
esv2749991 CNV Deletion 23290073
nsv527970 CNV Gain 19592680
esv2608620 CNV Deletion 19546169
esv271976 CNV Insertion 20981092
nsv904475 CNV Gain 21882294
nsv904476 CNV Gain 21882294
nsv827427 CNV Gain 20364138

Relevant External Links for NTRK3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTRK3 Gene

Disorders for NTRK3 Gene

(2) University of Copenhagen DISEASES for NTRK3 Gene

(48) Novoseek inferred disease relationships for NTRK3 Gene

Disease -log(P) Hits PubMed IDs
medulloblastoma 74.8 18
leukemia mast cell 69.8 2
medulloblastoma desmoplastic 64.8 1
gastrointestinal stromal tumor 62.9 10
mastocytoma 45 4

Relevant External Links for NTRK3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
genes like me logo Genes that share disorders with NTRK3: view

No data available for UniProtKB/Swiss-Prot for NTRK3 Gene

Publications for NTRK3 Gene

  1. Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant. (PMID: 7806211) McGregor L.M. … Nelkin B.D. (Genomics 1994) 2 3 4 23
  2. Genomic characterization of the human trkC gene. (PMID: 9778053) Ichaso N. … Gonzalez-Sarmiento R. (Oncogene 1998) 3 4 23
  3. Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. (PMID: 18293376) Marchetti A. … Buttitta F. (Hum. Mutat. 2008) 3 4 23
  4. Association of the neurotrophic tyrosine kinase receptor 3 (NTRK3) gene and childhood-onset mood disorders. (PMID: 18347002) Feng Y. … Barr C.L. (Am J Psychiatry 2008) 3 23 48
  5. Genetic susceptibility to obsessive-compulsive hoarding: the contribution of neurotrophic tyrosine kinase receptor type 3 gene. (PMID: 18616610) Alonso P. … Estivill X. (Genes Brain Behav. 2008) 3 23 48

Products for NTRK3 Gene

  • Addgene plasmids for NTRK3

Sources for NTRK3 Gene

Back to Top