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NTRK3 Gene

protein-coding   GIFtS: 75
GCID: GC15M088418

Neurotrophic Tyrosine Kinase, Receptor, Type 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neurotrophic Tyrosine Kinase, Receptor, Type 31 2     NT-3 Growth Factor Receptor2
TRKC2 3 5     Tyrosine Kinase Receptor C2
GP145-TrkC2 3     Trk-C3
EC 2.7.10.13 8     Neurotrophic Tyrosine Kinase Receptor Type 33
ETS Related Protein-Neurotrophic Receptor Tyrosine Kinase Fusion Protein2     TrkC Tyrosine Kinase3
ETV6-NTRK3 Fusion2     EC 2.7.108
gp145(trkC)2     

External Ids:    HGNC: 80331   Entrez Gene: 49162   Ensembl: ENSG000001405387   OMIM: 1913165   UniProtKB: Q162883   

Export aliases for NTRK3 gene to outside databases

Previous GC identifers: GC15M084556 GC15M081649 GC15M086007 GC15M086149 GC15M086221 GC15M088402 GC15M064532


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NTRK3 Gene:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a
membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.
Signalling through this kinase leads to cell differentiation and may play a role in the development of
proprioceptive neurons that sense body position. Mutations in this gene have been associated with
medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2011)

GeneCards Summary for NTRK3 Gene:
NTRK3 (neurotrophic tyrosine kinase, receptor, type 3) is a protein-coding gene. Diseases associated with NTRK3 include congenital mesoblastic nephroma, and fibrosarcoma. GO annotations related to this gene include ephrin receptor binding and p53 binding. An important paralog of this gene is ROR1.

UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288
Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the
trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties

Gene Wiki entry for NTRK3 (TrkC receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NTRK3 gene promoter:
         ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTRK3 promoter sequence
   Search Chromatin IP Primers for NTRK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTRK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25   Ensembl cytogenetic band:  15q25.3   HGNC cytogenetic band: 15q24-q25

NTRK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTRK3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M088418:  view genomic region     (about GC identifiers)

Start:
88,418,230 bp from pter      End:
88,799,999 bp from pter
Size:
381,770 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288 (See protein sequence)
Recommended Name: NT-3 growth factor receptor precursor  
Size: 839 amino acids; 94428 Da
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures.
Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity)
2 PDB 3D structures from and Proteopedia for NTRK3:
1WWC (3D)        3V5Q (3D)    
Secondary accessions: B7Z4C5 E9PG56 H0YND1 O75682 Q12827 Q16289
Alternative splicing: 5 isoforms:  Q16288-1   Q16288-2   Q16288-3   Q16288-4   Q16288-5   (No experimental confirmation)

Explore the universe of human proteins at neXtProt for NTRK3: NX_Q16288

Explore proteomics data for NTRK3 at MOPED

Post-translational modifications: 

  • Ligand-mediated auto-phosphorylation1
  • Glycosylation2 at Asn72, Asn79, Asn133, Asn163, Asn203, Asn218, Asn232, Asn259, Asn267, Asn272,
                                 Asn294, Asn375, Asn388
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NTRK3 (Q16288) (see all 32)
     YTLIAKN  CPKEVYD  RLNIKEI  TCNGSGS 


    See NTRK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001007157.1  NP_001012338.1  NP_001230030.1  NP_002521.2  

    ENSEMBL proteins: 
     ENSP00000377990   ENSP00000453959   ENSP00000473315   ENSP00000437773   ENSP00000453511  
     ENSP00000444673   ENSP00000473475   ENSP00000473656   ENSP00000354207   ENSP00000350356  
     ENSP00000347397   ENSP00000318328  

    NTRK3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NTRK3 (TrkC)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for NTRK3
    OriGene Protein Over-expression Lysate for NTRK3
    OriGene MassSpec for NTRK3
    OriGene Custom Protein Services for NTRK3
    GenScript Custom Purified and Recombinant Proteins Services for NTRK3
    Novus Biologicals NTRK3 Proteins
    Novus Biologicals NTRK3 Lysates
    Sino Biological Recombinant Protein for NTRK3
    Sino Biological Cell Lysate for NTRK3
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NTRK3

    NTRK3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NTRK3
    R&D Systems Antibodies for NTRK3 (TrkC)
    Cell Signaling Technology (CST) Antibodies for NTRK3  (TrkC)
    OriGene Antibodies for NTRK3
    OriGene Custom Antibody Services for NTRK3
    Novus Biologicals NTRK3 Antibodies
    Abcam antibodies for NTRK3
    Cloud-Clone Corp. Antibodies for NTRK3
    ThermoFisher Antibody for NTRK3
    LSBio Antibodies in human, mouse, rat for NTRK3

    NTRK3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NTRK3
    R&D Systems ELISAs for NTRK3 (TrkC)         (see all)
    GenScript Custom Assay Services for NTRK3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NTRK3
    Cloud-Clone Corp. CLIAs for NTRK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: neurotrophic tyrosine kinase, receptor, type 3
    Neurotrophin receptor/Trk family

    Selected InterPro protein domains (see all 17):
     IPR020446 Tyr_kin_neurotrophic_rcpt_3
     IPR017441 Protein_kinase_ATP_BS
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR013098 Ig_I-set

    Graphical View of Domain Structure for InterPro Entry Q16288

    ProtoNet protein and cluster: Q16288

    5 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB002011 Receptor tyrosine kinase
    IPB003599 Immunoglobulin subtype
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 protein kinase domain


    NTRK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTRK3_HUMAN, Q16288
    Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the
    trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

         Genatlas biochemistry entry for NTRK3:
    receptor tyrosine kinase C,linking neurotrophin 3 (NTF3),containing a CGG repeat in 5'utr,with a translocation
    t(12;15)(p13;q25) in congenital fibrosarcoma (CFS) and in congenital mesoblastic nephroma (CMN),involved in the
    survival and differentiation of nervous system and heart,and in tumour development

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI--
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IEA--
    GO:0005030neurotrophin receptor activity IDA--
         
    NTRK3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NTRK3:
     Decreased focal adhesion (FA)   Increased cell number in G1, a  Increased mitotic index 

         10 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ntrk3):
     behavior/neurological  cardiovascular system  growth/size/body  hearing/vestibular/ear  mortality/aging 
     nervous system  no phenotypic analysis  normal  respiratory system  vision/eye 

    NTRK3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NTRK3: Ntrk3tm1Par Ntrk3tm1Bbd Ntrk3tm1.1Tes

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NTRK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NTRK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTRK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTRK3

    miRNA
    Products:
        
    miRTarBase miRNAs that target NTRK3:
    hsa-mir-9-5p (MIRT003323), hsa-mir-198 (MIRT004911), hsa-mir-128-3p (MIRT000340), hsa-mir-765 (MIRT000030), hsa-mir-185-5p (MIRT005963), hsa-mir-625-5p (MIRT004914), hsa-mir-509-3p (MIRT004915), hsa-mir-384 (MIRT004909), hsa-mir-615-3p (MIRT040195), hsa-mir-617 (MIRT004881), hsa-mir-345-5p (MIRT004882), hsa-mir-125b-5p (MIRT003754), hsa-mir-330-3p (MIRT004910), hsa-mir-485-3p (MIRT000045), hsa-mir-125a-5p (MIRT003755), hsa-mir-151a-3p (MIRT005962), hsa-mir-768-5p (MIRT006599)

    Block miRNA regulation of human, mouse, rat NTRK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NTRK3 (see all 54):
    hsa-miR-142-5p hsa-let-7d hsa-miR-106a hsa-miR-765 hsa-miR-128 hsa-miR-3653 hsa-let-7g hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidNTRK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NTRK3
    Predesigned siRNA for gene silencing in human, mouse, rat NTRK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NTRK3

    Clone
    Products:
         
    OriGene clones in human, mouse for NTRK3 (see all 21)
    OriGene ORF clones in mouse, rat for NTRK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NTRK3 (NM_001007156)
    Sino Biological Human cDNA Clone for NTRK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTRK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTRK3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NTRK3
    Browse ESI BIO Cell Lines and PureStem Progenitors for NTRK3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTRK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NTRK3_HUMAN, Q16288: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0043235receptor complex IDA--

    NTRK3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NTRK3 About   (see all 24)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Actin-Based Motility by Rho Family GTPases0.62
    Apoptotic Pathways in Synovial Fibroblasts0.84
    ERK5 Signaling0.61
    p53 Mediated Apoptosis0.84
    eIF2 Pathway0.60
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NTRK3
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NTRK3 (see all 55)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for NTRK3
        Neuroscience

    3 Tocris Bioscience Pathways for NTRK3
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway

    2 GeneGo (Thomson Reuters) Pathways for NTRK3
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    2 BioSystems Pathways for NTRK3
        BDNF signaling pathway
    Neurotrophic factor-mediated Trk receptor signaling



    1 Kegg Pathway  (Kegg details for NTRK3):
        Neurotrophin signaling pathway


    NTRK3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NTRK3
    Interactions:

        GeneGlobe Interaction Network for NTRK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NTRK3 (Q162882, 3 ENSP000003542074) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN1P180312, 3, ENSP000003606834MINT-6793957 I2D: score=4 STRING: ENSP00000360683
    NTF3P207833, ENSP000003972974I2D: score=3 STRING: ENSP00000397297
    PLCG1P191743, ENSP000002440074I2D: score=2 STRING: ENSP00000244007
    SHC1P293533, ENSP000004013034I2D: score=2 STRING: ENSP00000401303
    SQSTM1Q135013, ENSP000003744554I2D: score=2 STRING: ENSP00000374455
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA--
    GO:0001764neuron migration IEA--
    GO:0001933negative regulation of protein phosphorylation IDA--
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IDA--

    NTRK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NTRK3

    2 HMDB Compounds for NTRK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 IUPHAR Ligand for NTRK3 (neurotrophic tyrosine kinase, receptor, type 3)    About this table
    LigandTypeActionAffinityPubmed IDs
    neurotrophin-3
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for NTRK3 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 81.2 208 7657612 (5), 12210087 (3), 7536501 (2), 17942918 (2) (see all 99)
    k252a 73.3 2 1312698 (1)
    imatinib 60.5 6 19369884 (1), 16779792 (1), 15044924 (1), 12389876 (1) (see all 5)
    o-tyrosine 44.2 1 11279608 (1)
    phosphatidylinositol 16.9 4 17991742 (1), 11751416 (1), 12393643 (1), 15654360 (1)
    retinoic acid 14.3 4 11520943 (1), 10051769 (1), 16996685 (1)
    threonine 0 2 9125498 (1)
    proline 0 1 10854035 (1)
    matrigel 0 1 9786961 (1)
    aspartate 0 3 7536501 (1), 12393643 (1)



    NTRK3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NTRK3 gene (4 alternative transcripts): 
    NM_001007156.2  NM_001012338.2  NM_001243101.1  NM_002530.3  

    Unigene Cluster for NTRK3:

    Neurotrophic tyrosine kinase, receptor, type 3
    Hs.410969  [show with all ESTs]
    Unigene Representative Sequence: NM_001007156
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000394480(uc002bmh.2 uc002bme.2 uc002bmf.2 uc021sua.1)
    ENST00000557856 ENST00000558576 ENST00000542733(uc010upl.1) ENST00000558676(uc010bnh.1)
    ENST00000559680 ENST00000560201 ENST00000558306 ENST00000540489 ENST00000537300
    ENST00000560739 ENST00000560017 ENST00000557897 ENST00000559764 ENST00000559188
    ENST00000559067 ENST00000360948 ENST00000357724
    miRNA
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    Block miRNA regulation of human, mouse, rat NTRK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NTRK3 (see all 54):
    hsa-miR-142-5p hsa-let-7d hsa-miR-106a hsa-miR-765 hsa-miR-128 hsa-miR-3653 hsa-let-7g hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidNTRK3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): NTRK3 (NM_001007156)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTRK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTRK3
    Primer
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    OriGene qPCR primer pairs and template standards for NTRK3
    OriGene qSTAR qPCR primer pairs in human, mouse for NTRK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NTRK3
      QuantiTect SYBR Green Assays in human, mouse, rat NTRK3
      QuantiFast Probe-based Assays in human, mouse, rat NTRK3

    Additional mRNA sequence: 

    AF052184.1 AF058389.1 AF058390.1 AF125808.1 AF125809.1 AK297160.1 AK302504.1 AK309695.1 
    AK313646.1 AY065844.1 BC013693.1 BC128249.1 BT007291.1 DQ323596.1 S76475.1 S76476.1 
    U05012.1 

    11 DOTS entries:

    DT.86854416  DT.92421160  DT.102828288  DT.100755429  DT.92421154  DT.75137184  DT.86854418  DT.95348504 
    DT.451766  DT.100703241  DT.92421158 

    Selected AceView cDNA sequences (see all 86):

    AW013956 CK903552 AF058389 BE047716 AF058390 AF052184 BC013693 AA700335 
    BF512741 BI966722 AI140305 CD723536 CD370531 BM887782 AI953850 CD172131 
    CA391718 AA371187 BP347900 AI368629 AW090568 AY065844 BE466711 BT007291 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NTRK3 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a ·
    SP1:                                                                                      -     -     -           -     -                       -               
    SP2:                                                                                      -     -     -           -     -                                       
    SP3:                                                                                      -     -     -                                                         
    SP4:                                                                    -                 -     -     -                                                         
    SP5:                                                                                                                                                            

    ExUns: 24b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for NTRK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NTRK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGGCTGTT
    NTRK3 Expression
    About this image


    NTRK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Perivascular Adipose
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
    NTRK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NTRK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.410969

    UniProtKB/Swiss-Prot: NTRK3_HUMAN, Q16288
    Tissue specificity: Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in
    adult brain than in fetal brain

        Custom PCR Arrays for NTRK3
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NTRK3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntrk31 , 5 neurotrophic tyrosine kinase, receptor, type 31, 5 91.03(n)1
    97.21(a)1
      7 (44.01 cM)5
    182131  NM_008746.51  NP_032772.31 
     781923625 
    chicken
    (Gallus gallus)
    Aves NTRK31 neurotrophic tyrosine kinase, receptor, type 3 82.12(n)
    88.92(a)
      396081  NM_205169.1  NP_990500.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    90(a)
    73(a)
    1 ↔ many
    1 ↔ many
    GL343641.1(57495-139618)
    GL343389.1(474956-985764)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ntrk31 neurotrophic tyrosine kinase, receptor, type 3 75.09(n)
    85.18(a)
      100487541  XM_004912650.1  XP_004912707.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntrk12 neurotrophic tyrosine kinase, receptor, type 1 76.81(n)   30546  S78348.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y69E1A.33 Eukaryotic protein kinase domain 33(a)   IV(10952641-10954803)   --


    ENSEMBL Gene Tree for NTRK3 (if available)
    TreeFam Gene Tree for NTRK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NTRK3 gene
    ROR12  INSR2  ROS12  NTRK22  LTK2  IGF1R2  DDR12  INSRR2  
    ROR22  DDR22  MUSK2  ALK2  NTRK12  
    14 SIMAP similar genes for NTRK3 using alignment to 9 protein entries:     NTRK3_HUMAN (see all proteins):
    ABL1    FGFR1    RET    DDR1    TYK2    TXK
    NTRK2    EPHA2    NTRK1    RYK    AURKC    trk2
    DKFZp686M05208    trk4

    NTRK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NTRK3 (see all 8601)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0414754
    A lung adenocarcinoma sample4--see VAR_0414752 H Y mis40--------
    VAR_0465244
    A lung carcinoma sample4--see VAR_0465242 Y F mis40--------
    VAR_0467704
    A lung large cell carcinoma sample4--see VAR_0467702 R F mis40--------
    VAR_0465214
    A lung carcinoma sample4--see VAR_0465212 A S mis40--------
    VAR_0465234
    A lung carcinoma sample4--see VAR_0465232 R P mis40--------
    VAR_0414714
    A gastric adenocarcinoma sample4--see VAR_0414712 T R mis40--------
    VAR_0414734
    A lung adenocarcinoma sample4--see VAR_0414732 V L mis40--------
    VAR_0414744
    A lung adenocarcinoma sample4--see VAR_0414742 L Q mis40--------
    VAR_0465224
    A lung carcinoma sample4--see VAR_0465222 W C mis40--------
    rs341471131,2
    C--64545442(+) TTTCC-/ATTT  
            
    ATTTA
    3 -- int10--------

    HapMap Linkage Disequilibrium report for NTRK3 (88418230 - 88668230 bp, first 250kb of NTRK3)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NTRK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749991CNV Deletion23290073
    esv2608620CNV Deletion19546169
    esv271976CNV Insertion20981092
    nsv94255CNV Loss16902084
    nsv904476CNV Gain21882294
    nsv904475CNV Gain21882294
    nsv827427CNV Gain20364138
    nsv527970CNV Gain19592680

    Human Gene Mutation Database (HGMD): NTRK3
    4 Site Specific Mutation Identification with PCR Assays for NTRK3:
    Cosmic IdAA Change
    21232p.L336Q
    12890p.H677Y
    21214p.V307L
    79006p.E556*
    SeqTarget long-range PCR primers for resequencing NTRK3
    DNA2.0 Custom Variant and Variant Library Synthesis for NTRK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191316    OMIM disorders: --

    Selected diseases for NTRK3 (see all 77):    
    About MalaCards
    congenital mesoblastic nephroma    fibrosarcoma    congenital fibrosarcoma    medulloblastoma
    mesoblastic nephroma    polymorphous low-grade adenocarcinoma    perivascular epithelioid cell tumor    mastocytosis
    thymic epithelial tumor    gastrointestinal stromal tumor    phyllode tumor    hirschsprung's disease
    childhood medulloblastoma    ganglioneuroma    systemic mastocytosis    anxiety disorder
    tuberous sclerosis complex    tetralogy of fallot    phaeochromocytoma    myeloproliferative disorder

    2 diseases from the University of Copenhagen DISEASES database for NTRK3:
    Fibrosarcoma     Congenital mesoblastic nephroma

    NTRK3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NTRK3 gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    medulloblastoma 74.8 21 16077909 (3), 9560008 (2), 15198123 (2), 8817419 (1) (see all 14)
    leukemia mast cell 69.8 3 7536501 (1), 9209403 (1)
    medulloblastoma desmoplastic 64.8 1 12471454 (1)
    gastrointestinal stromal tumor 62.9 10 12738950 (1), 16101174 (1), 19369884 (1), 11914627 (1) (see all 10)
    mastocytoma 45 6 7536501 (2), 7513208 (1), 9209403 (1)
    tumors 39 56 10994550 (2), 17942918 (2), 7604872 (2), 8552397 (2) (see all 36)
    sarcoma spindle cell 37.7 1 14668342 (1)
    pediatric solid tumor 36.3 1 11751416 (1)
    fibrosarcoma 36.1 4 11751416 (1), 12210087 (1), 9778053 (1)
    mastocytosis 36.1 2 11914627 (1), 12393643 (1)

    Genetic Association Database (GAD): NTRK3
    Human Genome Epidemiology (HuGE) Navigator: NTRK3 (21 documents)
    Tumor Gene Database (TGDB): NTRK3

    Export disorders for NTRK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NTRK3 gene, integrated from 10 sources (see all 453):
    (articles sorted by number of sources associating them with NTRK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant. (PubMed id 7806211)1, 2, 3, 9 McGregor L.M.... Nelkin B.D. (Genomics 1994)
    2. Association of the neurotrophic tyrosine kinase receptor 3 (NTRK3) gene and childhood-onset mood disorders. (PubMed id 18347002)1, 4, 9 Feng Y....Barr C.L. (Am J Psychiatry 2008)
    3. Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. (PubMed id 19370765)1, 4, 9 MuiA+os-Gimeno M....Espinosa-Parrilla Y. (Hum. Mutat. 2009)
    4. A novel point variant in NTRK3, R645C, suggests a role of this gene in the pathogenesis of Hirschsprung disease. (PubMed id 19040714)1, 4, 9 FernA!ndez R.M....Borrego S. (Ann. Hum. Genet. 2009)
    5. Evidence for a possible association of neurotrophin receptor (NTRK-3) gene polymorphisms with hippocampal function and schizophrenia. (PubMed id 19344762)1, 4, 9 Otnaess M.K....Andreassen O.A. (Neurobiol. Dis. 2009)
    6. Genetic susceptibility to obsessive-compulsive hoarding: the contribution of neurotrophic tyrosine kinase receptor type 3 gene. (PubMed id 18616610)1, 4, 9 Alonso P....Estivill X. (Genes Brain Behav. 2008)
    7. Genomic characterization of the human trkC gene. (PubMed id 9778053)1, 2, 9 Ichaso N.... Gonzalez-Sarmiento R. (Oncogene 1998)
    8. Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. (PubMed id 18293376)1, 2, 9 Marchetti A.... Buttitta F. (Hum. Mutat. 2008)
    9. Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. (PubMed id 18428117)1, 4, 9 Conner A.C....Thome J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    10. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. (PubMed id 7823156)1, 2, 9 Shelton D.L.... Levinson A.D. (J. Neurosci. 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4916 HGNC: 8033 AceView: NTRK3 Ensembl:ENSG00000140538 euGenes: HUgn4916
    ECgene: NTRK3 Kegg: 4916 H-InvDB: NTRK3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NTRK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NTRK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NTRK3 gene:
    Search GeneIP for patents involving NTRK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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