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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTRK2 Gene

protein-coding   GIFtS: 74
GCID: GC09P087283

neurotrophic tyrosine kinase, receptor, type 2
 Explore 95 diseases affiliated with
NTRK2 via
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 Human Malady Compendium 
Biological research products
for NTRK2    

Aliases
for NTRK2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neurotrophic Tyrosine Kinase, Receptor, Type 21 2     BDNF/NT-3 Growth Factors Receptor2
TRKB1 2 3 5     Trk-B3
TrkB Tyrosine Kinase2 3     Tyrosine Kinase Receptor B2
Tropomyosin-Related Kinase B2 3     Trk-B3
GP145-TrkB2 3     Neurotrophic Tyrosine Kinase Receptor Type 23
EC 2.7.10.13 8     EC 2.7.108
BDNF-Tropomyosine Receptor Kinase B2     

External Ids:    HGNC: 80321   Entrez Gene: 49152   Ensembl: ENSG000001480537   OMIM: 6004565   UniProtKB: Q166203   

Export aliases for NTRK2 gene to outside databases

Previous GC identifers: GC09P078328 GC09P079138 GC09P080839 GC09P082741 GC09P084514 GC09P086473 GC09P057108


Summaries
for NTRK2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NTRK2:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound
receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through
this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood
disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620
Function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral
nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse
formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively
can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival
through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits,
phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that
regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade
that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls
the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream
protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by
regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and
the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting
from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells
and mediate communication between neurons and glia

summary for NTRK2:
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase
activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling
pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.
p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds
different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is
involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in
neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is
involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by
neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors
with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as
an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NTRK2 (TrkB receptor)


Genomic Views
for NTRK2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NTRK2 gene promoter:
         AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NTRK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NTRK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTRK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1   Ensembl cytogenetic band:  9q21.33   HGNC cytogenetic band: 9q22.1

NTRK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTRK2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P087283:  view genomic region     (about GC identifiers)

Start:
 87,283,466 bp from pter      End:
 87,638,505 bp from pter
Size:
 355,040 bases      Orientation:
 plus strand

Proteins
for NTRK2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620 (See protein sequence)
Recommended Name: BDNF/NT-3 growth factors receptor precursor  
Size: 822 amino acids; 91999 Da
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures.
Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation. Interacts
(phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and activation.
Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the receptor. Interacts
(phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and KIDINS220 (By
similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling pathway
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I
membrane protein (By similarity). Note=Internalized to endosomes upon ligand-binding (By similarity)
Developmental stage: Widely expressed in fetal brain
Miscellaneous: Trk also stands for tropomyosin-related kinase since the first Trk was isolated as an oncogenic protein
which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1
6 PDB 3D structures from and Proteopedia for NTRK2:
1HCF (3D)        1WWB (3D)        4ASZ (3D)        4AT3 (3D)        4AT4 (3D)        4AT5 (3D)    
Secondary accessions: B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7
Alternative splicing: 7 isoforms:  Q16620-1   Q16620-2   Q16620-3   Q16620-4   Q16620-5   Q16620-6   Q16620-7   (Non-catalytic isoform)

Explore the universe of human proteins at neXtProt for NTRK2: NX_Q16620

Post-translational modifications:

  • Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and
    • other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated1
  • Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the
    • internalization of the receptor (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16620

    • 4/17 DME Specific Peptides for NTRK2 (Q16620) (see all 17)
     YTLIAKN  GVVLWEI  HHWCIPF  FVHRDLA 

    NTRK2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001007098.1  NP_001018074.1  NP_001018075.1  NP_001018076.1  NP_006171.2  

    ENSEMBL proteins: 
     ENSP00000365381   ENSP00000306167   ENSP00000277120   ENSP00000314586   ENSP00000352906  
     ENSP00000365387   ENSP00000365386   ENSP00000379221   ENSP00000379207  
    Reactome Protein details: Q16620
    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant NTRK2 Protein
    R&D Systems Recombinant & Natural Proteins for NTRK2 (TrkB)
    Enzo Life Sciences proteins for NTRK2
    OriGene Purified Proteins (see all 2): NTRK2
    OriGene Protein Over-expression Lysate (see all 6): NTRK2
    OriGene Custom Protein Services for NTRK2 
    GenScript Custom Purified and Recombinant Proteins Services for NTRK2
    Novus Biologicals NTRK2 Proteins
    Novus Biologicals NTRK2 Lysates
    Sino Biological Recombinant Protein for NTRK2
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NTRK2

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ----
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane IDA15494731
    GO:0009986cell surface IEA--


    NTRK2 for ontologies           About GeneDecksing



    NTRK2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NTRK2
    R&D Systems Antibodies for NTRK2 (TrkB)
    Cell Signaling Technology (CST) Antibodies for NTRK2  (TrkB)
    OriGene Antibodies (see all 3): NTRK2
    OriGene Custom Antibody Services for NTRK2 
    GenScript Custom Superior Antibodies Services for NTRK2
    Novus Biologicals NTRK2 Antibodies
    Abcam antibodies for NTRK2 
    Uscn Antibodies for NTRK2
    ThermoFisher Antibodies for NTRK2

    Assay Products for NTRK2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    R&D Systems ELISAs for NTRK2 (TrkB)         (see all)
    GenScript NTRK2-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for NTRK2 (TrkB)
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NTRK2

    Protein Domains /
    Families
    for NTRK2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NTRK2 for domains           About GeneDecksing

    5/15 InterPro domains/families (see all 15):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR017441 Protein_kinase_ATP_BS
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry Q16620

    ProtoNet protein and cluster: Q16620

    5 Blocks protein families:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB002011 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain
    Similarity: Contains 1 protein kinase domain


    Function
    for NTRK2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620
    Function: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral
    nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse
    formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively
    can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival
    through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits,
    phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that
    regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade
    that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls
    the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream
    protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by
    regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and
    the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting
    from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells
    and mediate communication between neurons and glia
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: The neuronal activity and the influx of calcium positively regulate the kinase activity and the
    internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the
    internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A
    inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors
    and signaling cascades. The formation of active receptors dimers able to fully transduce the ligand-mediated signal,
    may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms (By similarity)

         Genatlas biochemistry entry for NTRK2:
    receptor tyrosine kinase B,linking brain derived neurotrophic factor (BDNF),neurotrophin (NTF4)

    Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 5): NTRK2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTRK2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate NTRK2 (see all 34):
    hsa-miR-3678-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-3142 hsa-miR-149 hsa-miR-654-5p hsa-miR-298 hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTRK2 (see all 7)
    OriGene shRNA RFP: NTRK2
    OriGene siRNA: NTRK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTRK2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NTRK2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTRK2 (see all 9)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTRK2 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): NTRK2 (NM_006180)
    Sino Biological Human cDNA Clone for NTRK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTRK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTRK2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for NTRK2
    Search LifeMap BioReagents cell lines for NTRK2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTRK2

    Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0005030neurotrophin receptor activity ----
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0042803protein homodimerization activity ISS--


    NTRK2 for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for NTRK2:
     Decreased viability of wild-ty  Decreased viability with cispl  Increased cell death HMECs cel  Increased mitotic index 
     Synthetic lethal with c-Myc af 

    Animal Models:
         Mouse knock-outs for NTRK2: Ntrk2tm1Bbd Ntrk2tm1Lfp Ntrk2tm1.1Tes Ntrk2tm1Rohr
         12 MGI mutant phenotypes (inferred from 14 alleles) (MGI details for Ntrk2):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hearing/vestibular/ear 
     homeostasis/metabolism  mortality/aging  nervous system  normal  reproductive system 
     respiratory system  vision/eye 

    NTRK2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NTRK2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/31 super-pathways (see all 31) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Apoptotic Pathways in Synovial Fibroblasts
    8/13 pathways (see all 13)
    		Apoptotic Pathways in Synovial Fibroblasts1.00
    		ERK5 Signaling0.61
    		p53 Mediated Apoptosis0.84
    		eIF2 Pathway0.60
    		Mitochondrial Apoptosis0.73
    		Rac1 Pathway0.58
    		Telomerase Components in Cell Signaling0.72
    		Nuclear Receptor Activation by Vitamin-A0.57
    2GPCR Pathway
    		GPCR Pathway1.00
    		Estrogen Pathway0.55
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    		Breast Cancer Regulation by Stathmin10.58
    		Paxillin Interactions0.53
    		NFAT in Immune Response0.58
    		P2Y Receptor Signaling0.38
    3Rho Family GTPases
    		Rho Family GTPases1.00
    		MAPK Signaling0.51
    		ERK Signaling0.61
    		ILK Signaling0.45
    		Molecular Mechanisms of Cancer0.51
    4Nanog in Mammalian ESC Pluripotency
    		Nanog in Mammalian ESC Pluripotency1.00
    		14-3-3 Induced Intracellular Signaling0.59
    		GSK3 Signaling0.61
    		eNOS Signaling0.48
    5Apoptosis Pathway
    		Apoptosis Pathway1.00
    		Akt Pathway0.39
    		NF-kappaB Pathway0.45

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for NTRK2
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    5/58 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NTRK2 (see all 58)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for NTRK2
        Neuroscience
    Tyrosine Kinases / Adaptors

    3 Tocris Bioscience Pathways for NTRK2
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway

    2 GeneGo (Thomson Reuters) Pathways for NTRK2
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    2 BioSystems Pathways for NTRK2 
        SIDS Susceptibility Pathways
    Neurotrophic factor-mediated Trk receptor signaling

    5        Reactome Pathways for NTRK2
        Activation of TRKA receptors
    Signal Transduction
    Signalling by NGF
    NGF signalling via TRKA from the plasma membrane
    NGF-independant TRKA activation


    2         Kegg Pathways  (Kegg details for NTRK2):
        MAPK signaling pathway
    Neurotrophin signaling pathway


    NTRK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NTRK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for NTRK2 (Q166203 ENSP000002771204) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTF3P207833, ENSP000003972974I2D: score=3 STRING: ENSP00000397297
    PLCG1P191743, ENSP000002440074I2D: score=3 STRING: ENSP00000244007
    PTPN11Q061243, ENSP000003409444I2D: score=3 STRING: ENSP00000340944
    BDNFP235603, ENSP000004143034I2D: score=2 STRING: ENSP00000414303
    DYNLL1P631673, ENSP000002425774I2D: score=2 STRING: ENSP00000242577
    About this table

    Gene Ontology (GO): 5/36 biological process terms (GO ID links to tree view) (see all 36):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001764neuron migration ISS--
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS--
    GO:0007190activation of adenylate cyclase activity TAS--
    GO:0007568aging IEA--


    NTRK2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NTRK2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NTRK2 for compounds           About GeneDecksing

    EMD Millipore small molecules for NTRK2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NTRK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BDNF (human)Activates TrkB and p75 receptors[218441-99-7]
    7,8-Dihydroxyflavone TrkB agonist[38183-03-8]

    2 HMDB Compounds for NTRK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for NTRK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AmitriptylineAmitriprolidine (see all 7)50-48-6targetagonist19549602

    10/53 Novoseek chemical compound relationships for NTRK2 gene (see all 53)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    k252a 88.8 22 18959266 (3), 17880937 (2), 16790237 (1), 19390590 (1) (see all 16)
    tyrosine 82.5 320 14581459 (5), 7671810 (3), 11432792 (3), 11095525 (3) (see all 99)
    lestaurtinib 75 1 17611677 (1)
    liga 20 67.1 3 12388556 (1), 16477610 (1)
    nmda 46.2 22 9792641 (3), 17079678 (2), 14720220 (2), 11355310 (1) (see all 13)
    retinoic acid 44 31 8394722 (5), 15024057 (2), 12927207 (2), 10347207 (2) (see all 12)
    phosphatidylinositol 42.6 9 12438277 (2), 20186705 (1), 15169782 (1), 18201274 (1) (see all 6)
    ly294002 41.2 2 12438277 (1), 19711359 (1)
    pd 98,059 31.9 1 12438277 (1)
    glutamate 31.4 12 12470709 (1), 15183516 (1), 15650750 (1), 9765296 (1) (see all 9)

    Search CenterWatch for drugs/clinical trials and news about NTRK2 

    Transcripts
    for NTRK2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NTRK2 gene (5 alternative transcripts): 
    NM_001007097.1  NM_001018064.1  NM_001018065.2  NM_001018066.2  NM_006180.3  

    Unigene Cluster for NTRK2:

    Neurotrophic tyrosine kinase, receptor, type 2
    Hs.494312  [show with all ESTs]
    Unigene Representative Sequence: NM_001018065
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376208(uc011lta.2 uc004aoc.3) ENST00000304053(uc011lsz.2)
    ENST00000277120 ENST00000323115 ENST00000359847 ENST00000376214(uc004anz.1)
    ENST00000376213(uc004any.1 uc004aoa.1) ENST00000395882(uc004anv.1 uc004aob.1 uc011ltb.1)
    ENST00000395866

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 5): NTRK2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTRK2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate NTRK2 (see all 34):
    hsa-miR-3678-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-3142 hsa-miR-149 hsa-miR-654-5p hsa-miR-298 hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTRK2 (see all 7)
    OriGene shRNA RFP: NTRK2
    OriGene siRNA: NTRK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTRK2
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTRK2 (see all 9)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTRK2 (see all 5)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): NTRK2 (NM_006180)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTRK2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTRK2
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTRK2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTRK2

    Additional cDNA sequence: 

    AB209118.1 AF086101.1 AF400441.1 AF410898.1 AF410899.1 AF410900.1 AF410901.1 AF508964.1 
    AJ420458.1 AK092267.1 AK123824.1 AK289904.1 AK294285.1 AL713745.1 AL833196.1 BC031309.2 
    BC031835.1 BC075804.1 BX649001.1 S76473.1 S76474.1 U12140.1 X75958.1 

    24/25 DOTS entries (see all 25):

    DT.91747295  DT.448703  DT.121204490  DT.100740853  DT.121204472  DT.214737  DT.121204415  DT.410237 
    DT.97844809  DT.121204487  DT.91932613  DT.100815740  DT.121204437  DT.121204432  DT.121204436  DT.92029358 
    DT.95148701  DT.100735567  DT.100815737  DT.100735568  DT.121204427  DT.121204451  DT.121204492  DT.91746504 

    24/292 AceView cDNA sequences (see all 292):

    AI341407 BP346852 AL603196 AI589649 BF195143 AI263387 BQ575614 BF432231 
    AI880198 F11078 AI081305 AA041195 AW770836 AW292267 AI857927 AI569710 
    BM931197 AF410901 C00423 AI655270 BX106263 AI654620 AL134306 AI867454 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NTRK2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                      -     -                                                                                         -           -         
    SP2:                                      -     -                                                                                         -     -     -         
    SP3:                                                                                                                                      -     -     -         
    SP4:                                      -     -                                                                                         -           -         
    SP5:                                      -     -                                                                                         -     -     -         

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b
    SP1:  -                       -     -                     
    SP2:  -                                                   
    SP3:  -                       -     -                     
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for NTRK2

    Expression
    for NTRK2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTRK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCCTGTTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NTRK2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryPrimary FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    OvaryPrimordial FolliclePrimary OocyteFemale Gametocytes, Germ Cells
    Skeletal MuscleHyoid Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMuscle Progenitor CellsSkeletal Muscle
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)
    Beating cell clusters (Spontaneous differen...)

    See NTRK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTRK2

    SOURCE GeneReport for Unigene cluster: Hs.494312

    UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620
    Tissue specificity: Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous
    system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of
    the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial
    ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal
    root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas,
    kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including NTRK2 (see all 8): 
              Parkinson's Disease in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for NTRK2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NTRK2 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NTRK21 neurotrophic tyrosine kinase, receptor, type 2 76.98(n)
    78(a)    		   396157  NM_205231.1  NP_990562.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NTRK26
    		 --
    		 77(a)
    		 1 ↔ 1
    		 2(42153883-42312813)
    African clawed frog
    (Xenopus laevis)    		 Amphibia trkb-B-prov2 neurotrophin receptor B xTrkB-alpha 74.63(n)    U39670.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ntrk2a1 neurotrophic tyrosine kinase, receptor, type 2a 65.71(n)
    66.84(a)    		   65090  XM_003199145.1  XP_003199193.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 25(a)
    		 1 → many
    		 GroupUn.109(136008-146827)


    ENSEMBL Gene Tree for NTRK2 (if available)
    TreeFam Gene Tree for NTRK2 (if available) 

    Paralogs
    for NTRK2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTRK2 gene
    INSR2  ROR12  ROS12  LTK2  IGF1R2  DDR12  NTRK32  ROR22  
    INSRR2  DDR22  MUSK2  ALK2  NTRK12  
    4 SIMAP similar genes for NTRK2 using alignment to 5 protein entries:     NTRK2_HUMAN (see all proteins):
    EPHA2    NTRK3    NTRK1    FRK

    NTRK2 for paralogs           About GeneDecksing



    Genomic Variants
    for NTRK2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6912 NCBI SNPs in NTRK2 are shown (see all 6912)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs78716431,2
    		C,F,--57106862(+) ggatcA/Gtggtc 2 -- us2k11Minor allele frequency- G:0.03WA 118
    rs800636101,2
    		C,F,--57108311(+) CTATAT/CTTTGA 5 -- us2k11Minor allele frequency- C:0.15WA 118
    rs111407241,2
    		--57108360(+) TTGCCC/TGCCTT 5 -- us2k10--------
    rs1117769231,2
    		C,--57108415(+) CGGCCG/AGGCAG 5 -- us2k12Minor allele frequency- A:0.18NA 122
    rs1887906171,2
    		C,--57108741(+) CCCGGA/GTCGCC 5 -- ut51 us2k10--------
    rs1132099571,2
    		C,--57108927(+) GGTGGG/ACATCG 5 -- int1 us2k12Minor allele frequency- A:0.05WA 120
    rs1815669281,2
    		C,--57109731(+) GTGTTA/GTGGGT 5 -- int1 us2k10--------
    rs734806001,2
    		C,F,--57109829(+) ACTTCG/TCCAGC 5 -- ut511Minor allele frequency- T:0.04WA 118
    rs1860565571,2
    		C,--57109883(+) CAGGAA/GCCTCG 5 -- ut510--------
    rs775629291,2
    		C,--57110548(+) CCGCCG/TGTCGG 5 -- ut510--------

    HapMap Linkage Disequilibrium report for NTRK2 (87283466 - 87533466 bp, first 250kb of NTRK2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 13 variations for NTRK2
         2 CNVs: 100686 100685
         10 Indels: 62920 96158 96159 83085 65435 47742 42194 70746 100687 47743
         1 Inversion: 29497
    Human Gene Mutation Database (HGMD): NTRK2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NTRK2
    DNA2.0 Custom Variant and Variant Library Synthesis for NTRK2

    Disorders / Diseases
    for NTRK2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NTRK2 for disorders           About GeneDecksing

    OMIM gene information: 600456    OMIM disorders: --

    UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620
  • Defects in NTRK2 are the cause of obesity hyperphagia and developmental delay (OHPDD) [MIM:613886]. OHPDD is a
    • disorder characterized by early-onset obesity, hyperphagia, and severe developmental delay in motor function, speech,
    and language

    20/95 diseases for NTRK2 (see all 95):    About MalaCards
    mood disorder    obesity, hyperphagia, and developmental delay    open-angle glaucoma    thyroid carcinoma
    obesity    obsessive-compulsive disorder    primary open angle glaucoma    attention deficit hyperactivity disorder
    carcinoma    amyotrophic lateral sclerosis    thyroiditis    temporal lobe epilepsy
    hereditary sensory neuropathy    primitive neuroectodermal tumor    status epilepticus    eating disorder
    major depressive disorder    thymic epithelial tumor    neuronitis    lateral sclerosis

    1 disease from the University of Copenhagen DISEASES database for NTRK2:
    Nicotine dependence

    10/49 Novoseek disease relationships for NTRK2 gene (see all 49)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sensory neuropathy hereditary 50.1 1 8895241 (1)
    neurodegenerative diseases 45.7 1 9692719 (1)
    medulloblastoma 41.3 5 9560008 (2), 10994550 (1), 8774147 (1)
    ganglioneuroma 34.2 3 8264643 (1), 10217562 (1)
    dysautonomia familial 33.3 4 7759111 (2), 8895241 (1)
    major depression 31.3 15 11041531 (4), 16905274 (2), 20202475 (2), 20014955 (2) (see all 7)
    alzheimers disease 30 13 15726264 (2), 17069877 (1), 8931004 (1), 16023301 (1) (see all 8)
    ganglioglioma 29.7 1 9625303 (1)
    myeloma 23.3 7 16409727 (3), 15657181 (1), 17889702 (1)
    tumors 22.4 70 20101235 (3), 10200298 (2), 11355310 (2), 12438277 (2) (see all 43)

    Genetic Association Database (GAD): NTRK2
    Human Genome Epidemiology (HuGE) Navigator: NTRK2 (44 documents)
    Tumor Gene Database (TGDB): NTRK2

    Export disorders for NTRK2 gene to outside databases

    Publications
    for NTRK2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTRK2 gene, integrated from 9 sources (see all 637):
    (articles sorted by number of sources associating them with NTRK2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2). (PubMed id 7789988)1, 2, 3, 9 Nakagawara A.... Brodeur G.M. (1995)
    2. Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, harm avoidance and minimum body mass index. (PubMed id 15838534)1, 4, 9 Ribases M....Estivill X. (2005)
    3. Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. (PubMed id 18293376)1, 2, 9 Marchetti A.... Buttitta F. (2008)
    4. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. (PubMed id 15494731)1, 2, 9 Yeo G.S....Farooqi I.S. (2004)
    5. Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC. (PubMed id 10388563)1, 2, 9 Ultsch M.H.... de Vos A.M. (1999)
    6. Human TrkB gene: novel alternative transcripts, prote in isoforms and expression pattern in the prefrontal cerebral cortex during pos tnatal development. (PubMed id 20193039)1, 2, 9 Luberg K....Timmusk T. (2010)
    7. Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. (PubMed id 7823156)1, 2, 9 Shelton D.L.... Levinson A.D. (1995)
    8. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    9. Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood-onset mood disorders. (PubMed id 15389758)1, 4 Adams J.H....Barr C.L. (2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    External Searches for NTRK2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NTRK2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4915 HGNC: 8032 AceView: NTRK2 Ensembl:ENSG00000148053 euGenes: HUgn4915
    ECgene: NTRK2 Kegg: 4915 H-InvDB: NTRK2

    Other Databases showing NTRK2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NTRK2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTRK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NTRK2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NTRK2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NTRK2 gene:
    Search GeneIP for patents involving NTRK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NTRK2 gene

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    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of NTRK2
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     NTRK2 Proteins, Antibodies, CLIAs, and ELISAs
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