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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTRK2 Gene

protein-coding   GIFtS: 74
GCID: GC09P087283

Neurotrophic Tyrosine Kinase, Receptor, Type 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Neurotrophic Tyrosine Kinase, Receptor, Type 21 2     BDNF/NT-3 Growth Factors Receptor2
TRKB2 3 5     trk-B2
TrkB Tyrosine Kinase2 3     Tyrosine Kinase Receptor B2
Tropomyosin-Related Kinase B2 3     Trk-B3
GP145-TrkB2 3     Neurotrophic Tyrosine Kinase Receptor Type 23
EC 2.7.10.13 8     EC 2.7.108
BDNF-Tropomyosine Receptor Kinase B2     

External Ids:    HGNC: 80321   Entrez Gene: 49152   Ensembl: ENSG000001480537   OMIM: 6004565   UniProtKB: Q166203   

Export aliases for NTRK2 gene to outside databases

Previous GC identifers: GC09P078328 GC09P079138 GC09P080839 GC09P082741 GC09P084514 GC09P086473 GC09P057108


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTRK2 Gene:
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a
membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.
Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with
obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for NTRK2 Gene: 
NTRK2 (neurotrophic tyrosine kinase, receptor, type 2) is a protein-coding gene. Diseases associated with NTRK2 include obesity hyperphagia and developmental delay, and mood disorder, and among its related super-pathways are Development Neurotrophin family signaling and Rac1 Pathway. GO annotations related to this gene include neurotrophin binding and protein homodimerization activity. An important paralog of this gene is ROR1.

UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620
Function: Receptor tyrosine kinase involved in the development and the maturation of the central and the
peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and
synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4.
Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates
neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and
activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1,
SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates
the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth.
Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and
survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity.
Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term
potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival.
Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also
play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons
and glia

summary for NTRK2 Gene:
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase
activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling
pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.
p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds
different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is
involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in
neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is
involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by
neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors
with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as
an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NTRK2 (TrkB receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NTRK2 gene promoter:
         AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTRK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for NTRK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTRK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.1   Ensembl cytogenetic band:  9q21.33   HGNC cytogenetic band: 9q22.1

NTRK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTRK2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P087283:  view genomic region     (about GC identifiers)

Start:
87,283,466 bp from pter      End:
87,638,505 bp from pter
Size:
355,040 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620 (See protein sequence)
Recommended Name: BDNF/NT-3 growth factors receptor precursor  
Size: 822 amino acids; 91999 Da
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures.
Interacts (phosphorylated upon activation by BDNF) with SHC1; mediates SHC1 phosphorylation and activation.
Interacts (phosphorylated upon activation by BDNF) with PLCG1 and/or PLCG2; mediates PLCG1 phosphorylation and
activation. Interacts with SH2B1 and SH2B2. Interacts with NGFR; may regulate the ligand specificity of the
receptor. Interacts (phosphorylated upon ligand-binding) with SH2D1A; regulates NTRK2. Interacts with SQSTM1 and
KIDINS220 (By similarity). Interacts (phosphorylated upon ligand-binding) with FRS2; activates the MAPK signaling
pathway
Subcellular location: Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I
membrane protein (By similarity). Note=Internalized to endosomes upon ligand-binding (By similarity)
Developmental stage: Widely expressed in fetal brain
Miscellaneous: Trk also stands for tropomyosin-related kinase since the first Trk was isolated as an oncogenic
protein which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1
6 PDB 3D structures from and Proteopedia for NTRK2:
1HCF (3D)        1WWB (3D)        4ASZ (3D)        4AT3 (3D)        4AT4 (3D)        4AT5 (3D)    
Secondary accessions: B1ANZ4 B4DFV9 Q16675 Q59GJ1 Q8WXJ5 Q8WXJ6 Q8WXJ7
Alternative splicing: 7 isoforms:  Q16620-1   Q16620-2   Q16620-3   Q16620-4   Q16620-5   Q16620-6   Q16620-7   (Non-catalytic isoform)

Explore the universe of human proteins at neXtProt for NTRK2: NX_Q16620

Explore proteomics data for NTRK2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1
    and other downstream effectors. Isoform TrkB-T-Shc is not phosphorylated
  • UniProtKB: Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the
    internalization of the receptor (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16620

  • 4/17 DME Specific Peptides for NTRK2 (Q16620) (see all 17)
     YTLIAKN  GVVLWEI  HHWCIPF  FVHRDLA 

    NTRK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NTRK2 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001007098.1  NP_001018074.1  NP_001018075.1  NP_001018076.1  NP_006171.2  

    ENSEMBL proteins: 
     ENSP00000365381   ENSP00000306167   ENSP00000277120   ENSP00000314586   ENSP00000352906  
     ENSP00000365387   ENSP00000365386   ENSP00000379221   ENSP00000379207  
    Reactome Protein details: Q16620
    Human Recombinant Protein Products for NTRK2: 
    EMD Millipore Purified and/or Recombinant NTRK2 Protein
    R&D Systems Recombinant & Natural Proteins for NTRK2 (TrkB)
    Enzo Life Sciences proteins for NTRK2
    OriGene Purified Proteins for NTRK2
    OriGene Protein Over-expression Lysate for NTRK2
    OriGene MassSpec for NTRK2 
    OriGene Custom Protein Services for NTRK2
    GenScript Custom Purified and Recombinant Proteins Services for NTRK2
    Novus Biologicals NTRK2 Proteins
    Novus Biologicals NTRK2 Lysates
    Sino Biological Recombinant Protein for NTRK2
    Sino Biological Cell Lysate for NTRK2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NTRK2 

    Gene Ontology (GO): 5/16 cellular component terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane ----
    GO:0005887integral to plasma membrane IDA15494731
    GO:0009986cell surface IEA--
    GO:0010008endosome membrane IEA--

    NTRK2 for ontologies           About GeneDecksing



    NTRK2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NTRK2
    R&D Systems Antibodies for NTRK2 (TrkB)
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    OriGene Custom Antibody Services for NTRK2
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    Novus Biologicals NTRK2 Antibodies
    Abcam antibodies for NTRK2
    Cloud-Clone Corp. Antibodies for NTRK2 
    ThermoFisher Antibodies for NTRK2
    LSBio Antibodies in human, mouse, rat for NTRK2 

    Assay Products for NTRK2: 
    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for NTRK2 (TrkB)         (see all)
    GenScript NTRK2-Activity-based Kinase Assay for Compound Screening
    Cell Signaling Technology (CST) Sandwich ELISA Kits for NTRK2 (TrkB)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NTRK2 
    Cloud-Clone Corp. CLIAs for NTRK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: neurotrophic tyrosine kinase, receptor, type 2 
    Neurotrophin receptor/Trk family

    5/15 InterPro protein domains (see all 15):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR017441 Protein_kinase_ATP_BS
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N

    Graphical View of Domain Structure for InterPro Entry Q16620

    ProtoNet protein and cluster: Q16620

    5 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB002011 Receptor tyrosine kinase
    IPB003598 Immunoglobulin C-2 type
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain
    Similarity: Contains 1 protein kinase domain


    NTRK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTRK2_HUMAN, Q16620
    Function: Receptor tyrosine kinase involved in the development and the maturation of the central and the
    peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and
    synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4.
    Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates
    neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and
    activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1,
    SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates
    the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth.
    Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and
    survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity.
    Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term
    potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival.
    Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also
    play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons
    and glia
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: The neuronal activity and the influx of calcium positively regulate the kinase activity and the
    internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control
    the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4.
    SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream
    effectors and signaling cascades. The formation of active receptors dimers able to fully transduce the
    ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the
    non-catalytic isoforms (By similarity)

         Genatlas biochemistry entry for NTRK2:
    receptor tyrosine kinase B,linking brain derived neurotrophic factor (BDNF),neurotrophin (NTF4)

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity ----
    GO:0005030neurotrophin receptor activity ----
    GO:0005515protein binding ----
         
    NTRK2 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for NTRK2:
     Decreased viability of wild-ty  Decreased viability with cispl  Increased cell death HMECs cel  Increased mitotic index 
     Synthetic lethal with c-Myc af 

         12 MGI mutant phenotypes (inferred from 16 alleles(MGI details for Ntrk2):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size  hearing/vestibular/ear 
     homeostasis/metabolism  mortality/aging  nervous system  normal  reproductive system 
     respiratory system  vision/eye 

    NTRK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NTRK2: Ntrk2tm1Bbd Ntrk2tm1Lfp Ntrk2tm1.1Tes Ntrk2tm1Rohr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NTRK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NTRK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTRK2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTRK2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTRK2
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate NTRK2 (see all 34):
    hsa-miR-3678-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-3142 hsa-miR-149 hsa-miR-654-5p hsa-miR-298 hsa-miR-200b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NTRK2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTRK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NTRK2
    Sirion Biotech Customized adenovirus for overexpression of NTRK2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NTRK2 (see all 29)
    OriGene ORF clones in mouse, rat for NTRK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): NTRK2 (NM_006180)
    Sino Biological Human cDNA Clone for NTRK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTRK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTRK2
    Sirion Biotech Customized lentivirus for stable overexpression of NTRK2 
                         Customized lentivirus expression plasmids for stable overexpression of NTRK2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTRK2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NTRK2 About   (see all 34)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Actin-Based Motility by Rho Family GTPases0.62
    Apoptotic Pathways in Synovial Fibroblasts0.84
    ERK5 Signaling0.61
    p53 Mediated Apoptosis0.84
    eIF2 Pathway0.60
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58
    5Nanog in Mammalian ESC Pluripotency
    Nanog in Mammalian ESC Pluripotency0.61
    14-3-3 Induced Intracellular Signaling0.59
    GSK3 Signaling0.61
    eNOS Signaling0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for NTRK2
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    1 R&D Systems Pathway for NTRK2
        Akt Signaling Pathway

    5/58 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NTRK2 (see all 58)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for NTRK2
        Neuroscience
    Tyrosine Kinases / Adaptors

    3 Tocris Bioscience Pathways for NTRK2
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway

    2 GeneGo (Thomson Reuters) Pathways for NTRK2
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    3 BioSystems Pathways for NTRK2
        SIDS Susceptibility Pathways
    BDNF signaling pathway
    Neurotrophic factor-mediated Trk receptor signaling


    5        Reactome Pathways for NTRK2
        Activation of TRKA receptors
    Signal Transduction
    Signalling by NGF
    NGF signalling via TRKA from the plasma membrane
    NGF-independant TRKA activation


    3         Kegg Pathways  (Kegg details for NTRK2):
        MAPK signaling pathway
    Neurotrophin signaling pathway
    Alcoholism


    NTRK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NTRK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for NTRK2 (Q166203 ENSP000002771204) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NTF3P207833, ENSP000003972974I2D: score=3 STRING: ENSP00000397297
    PLCG1P191743, ENSP000002440074I2D: score=3 STRING: ENSP00000244007
    PTPN11Q061243, ENSP000003409444I2D: score=3 STRING: ENSP00000340944
    BDNFP235603, ENSP000004143034I2D: score=2 STRING: ENSP00000414303
    DYNLL1P631673, ENSP000002425774I2D: score=2 STRING: ENSP00000242577
    About this table

    Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001570vasculogenesis IEA--
    GO:0001764neuron migration ISS--
    GO:0006468protein phosphorylation ----
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS--
    GO:0007190activation of adenylate cyclase activity TAS--

    NTRK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NTRK2 for compounds           About GeneDecksing

    EMD Millipore small molecules for NTRK2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for NTRK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BDNF (human)Activates TrkB and p75 receptors[218441-99-7]
    ANA 12TrkB receptor antagonist[219766-25-3]
    GNF 5837 Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC [1033769-28-6]
    TLQP 21VGF-derived peptide[869988-94-3]
    7,8-Dihydroxyflavone TrkB agonist[38183-03-8]

    2 HMDB Compounds for NTRK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    1 DrugBank Compound for NTRK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    AmitriptylineAmitriprolidine (see all 5)50-48-6targetagonist19549602

    10/53 Novoseek inferred chemical compound relationships for NTRK2 gene (see all 53)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    k252a 88.8 22 18959266 (3), 17880937 (2), 16790237 (1), 19390590 (1) (see all 16)
    tyrosine 82.5 320 14581459 (5), 7671810 (3), 11432792 (3), 11095525 (3) (see all 99)
    lestaurtinib 75 1 17611677 (1)
    liga 20 67.1 3 12388556 (1), 16477610 (1)
    nmda 46.2 22 9792641 (3), 17079678 (2), 14720220 (2), 11355310 (1) (see all 13)
    retinoic acid 44 31 8394722 (5), 15024057 (2), 12927207 (2), 10347207 (2) (see all 12)
    phosphatidylinositol 42.6 9 12438277 (2), 20186705 (1), 15169782 (1), 18201274 (1) (see all 6)
    ly294002 41.2 2 12438277 (1), 19711359 (1)
    pd 98,059 31.9 1 12438277 (1)
    glutamate 31.4 12 12470709 (1), 15183516 (1), 15650750 (1), 9765296 (1) (see all 9)

    1 PharmGKB related drug/compound annotation for NTRK2 gene    About this table
    Drug/compound PharmGKB Annotation
    methadoneCA  

    Search CenterWatch for drugs/clinical trials and news about NTRK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NTRK2 gene (5 alternative transcripts): 
    NM_001007097.1  NM_001018064.1  NM_001018065.2  NM_001018066.2  NM_006180.3  

    Unigene Cluster for NTRK2:

    Neurotrophic tyrosine kinase, receptor, type 2
    Hs.494312  [show with all ESTs]
    Unigene Representative Sequence: NM_001018065
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000376208(uc011lta.2 uc004aoc.3) ENST00000304053(uc011lsz.2)
    ENST00000277120 ENST00000323115 ENST00000359847 ENST00000376214(uc004anz.1)
    ENST00000376213(uc004any.1 uc004aoa.1) ENST00000395882(uc004anv.1 uc004aob.1 uc011ltb.1)
    ENST00000395866

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    hsa-miR-3678-3p hsa-miR-429 hsa-miR-513a-5p hsa-miR-3142 hsa-miR-149 hsa-miR-654-5p hsa-miR-298 hsa-miR-200b
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    Additional mRNA sequence: 

    AB209118.1 AF086101.1 AF400441.1 AF410898.1 AF410899.1 AF410900.1 AF410901.1 AF508964.1 
    AJ420458.1 AK092267.1 AK123824.1 AK289904.1 AK294285.1 AL713745.1 AL833196.1 BC031309.2 
    BC031835.1 BC075804.1 BX649001.1 S76473.1 S76474.1 U12140.1 X75958.1 

    24/25 DOTS entries (see all 25):

    DT.91747295  DT.448703  DT.121204490  DT.100740853  DT.121204472  DT.214737  DT.121204415  DT.410237 
    DT.97844809  DT.121204487  DT.91932613  DT.100815740  DT.121204437  DT.121204432  DT.121204436  DT.92029358 
    DT.95148701  DT.100735567  DT.100815737  DT.100735568  DT.121204427  DT.121204451  DT.121204492  DT.91746504 

    24/292 AceView cDNA sequences (see all 292):

    AW770836 F07084 F02972 AI341407 BQ188874 BF195143 AA457077 AI589649 
    AI263387 F02789 F11078 AA041195 AL603196 AF400441 BM931197 BQ575614 
    AA041432 BP346852 BX106263 CK824574 AW292267 CB154756 AA347011 AA456968 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NTRK2 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                                      -     -                                                                                         -           -         
    SP2:                                      -     -                                                                                         -     -     -         
    SP3:                                                                                                                                      -     -     -         
    SP4:                                      -     -                                                                                         -           -         
    SP5:                                      -     -                                                                                         -     -     -         

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b
    SP1:  -                       -     -                     
    SP2:  -                                                   
    SP3:  -                       -     -                     
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for NTRK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTRK2 expression in normal human tissues (normalized intensities)      NTRK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTGTTTTT
    NTRK2 Expression
    About this image


    NTRK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 32 entries
             Oligodendrocyte Precursor Cells Forebrain White Matter
             Thalamus
             Globus Pallidus   
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Gonad
             Primary Oocyte Primordial Follicle
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Normal Human Articular chondrocytes (NHAC)   
     
     Spinal Cord (Nervous System)
             Dorsal Horn   

    See NTRK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTRK2

    SOURCE GeneReport for Unigene cluster: Hs.494312

    UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620
    Tissue specificity: Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous
    system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular
    layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many
    cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary
    glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other
    tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including NTRK2 (see all 8): 
              Parkinson's Disease in human mouse rat
              Angiogenic Growth Factors in human mouse rat
              WNT Signaling Targets in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NTRK2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntrk21 , 5 neurotrophic tyrosine kinase, receptor, type 21, 5 87.62(n)1
    94.03(a)1
      13 (31.20 cM)5
    182121  NM_001025074.11  NP_001020245.11 
     588065965 
    chicken
    (Gallus gallus)
    Aves NTRK21 neurotrophic tyrosine kinase, receptor, type 2 76.98(n)
    78(a)
      396157  NM_205231.1  NP_990562.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTRK26
    neurotrophic tyrosine kinase, receptor, type 2
    70(a)
    1 ↔ 1
    2(42153883-42342079)
    African clawed frog
    (Xenopus laevis)
    Amphibia trkb-B-prov2 neurotrophin receptor B xTrkB-alpha 74.63(n)    U39670.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntrk2a1 neurotrophic tyrosine kinase, receptor, type 2a 65.71(n)
    66.84(a)
      65090  XM_003199145.1  XP_003199193.1 


    ENSEMBL Gene Tree for NTRK2 (if available)
    TreeFam Gene Tree for NTRK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTRK2 gene
    ROR12  INSR2  ROS12  LTK2  IGF1R2  PTK72  DDR12  NTRK32  
    INSRR2  ROR22  DDR22  MUSK2  ALK2  NTRK12  
    4 SIMAP similar genes for NTRK2 using alignment to 5 protein entries:     NTRK2_HUMAN (see all proteins):
    EPHA2    NTRK3    NTRK1    FRK

    NTRK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7909 SNPs in NTRK2 are shown (see all 7909)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0658904
    Obesity hyperphagia and developmental delay (OHPDD)4--see VAR_0658902 Y C mis40--------
    VAR_0465184
    A lung carcinoma sample4--see VAR_0465182 M I mis40--------
    VAR_0465204
    A lung carcinoma sample4--see VAR_0465202 R C mis40--------
    VAR_0465194
    A lung carcinoma sample4--see VAR_0465192 R G mis40--------
    VAR_0414704
    A lung adenocarcinoma sample4--see VAR_0414702 L F mis40--------
    VAR_0163204
    ----see VAR_0163202 G R mis40--------
    rs577280391,2
    C--57160273(+) AAAAA-/A/AA  
            
    GGGAG
    5 -- int11NA 2
    rs38245181,2
    C,F,H--57169688(+) CAAACA/GTGACT 5 -- int110Minor allele frequency- G:0.04NS EA NA 972
    rs2013914311,2
    --57233186(+) AACTC-/TGAGCTA 5 -- int10--------
    rs3690208971,2
    C--57233663(+) AAAAAA/-TTGCC 5 -- int11Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for NTRK2 (87283466 - 87533466 bp, first 250kb of NTRK2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for NTRK2 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1009365CNV Deletion20482838
    esv2738670CNV Deletion23290073
    esv2214442CNV Deletion18987734
    esv2424316CNV Deletion19546169
    esv2667995CNV Deletion23128226
    esv1919120CNV Deletion18987734
    esv2738671CNV Deletion23290073
    esv2738672CNV Deletion23290073
    esv2434739CNV Deletion19546169
    esv2662088CNV Deletion23128226


    Human Gene Mutation Database (HGMD): NTRK2
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600456    OMIM disorders: --

    UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620
  • Obesity hyperphagia and developmental delay (OHPDD) [MIM:613886]: A disorder characterized by early-onset
    obesity, hyperphagia, and severe developmental delay in motor function, speech, and language. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 20/87 diseases for NTRK2 (see all 87):    About MalaCards
    obesity hyperphagia and developmental delay    mood disorder    dysautonomia    olfactory neuroblastoma
    ganglioneuroma    hereditary sensory neuropathy    ganglioglioma    thymic epithelial tumor
    endometriosis    eating disorder    obesity    ovarian endometriosis
    phaeochromocytoma    obsessive-compulsive disorder    nicotine dependence    status epilepticus
    adenomyosis    nephroblastoma    paraganglioma    open-angle glaucoma

    1 disease from the University of Copenhagen DISEASES database for NTRK2:
    Nicotine dependence

    NTRK2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/49 Novoseek inferred disease relationships for NTRK2 gene (see all 49)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sensory neuropathy hereditary 50.1 1 8895241 (1)
    neurodegenerative diseases 45.7 1 9692719 (1)
    medulloblastoma 41.3 5 9560008 (2), 10994550 (1), 8774147 (1)
    ganglioneuroma 34.2 3 8264643 (1), 10217562 (1)
    dysautonomia familial 33.3 4 7759111 (2), 8895241 (1)
    major depression 31.3 15 11041531 (4), 16905274 (2), 20202475 (2), 20014955 (2) (see all 7)
    alzheimers disease 30 13 15726264 (2), 17069877 (1), 8931004 (1), 16023301 (1) (see all 8)
    ganglioglioma 29.7 1 9625303 (1)
    myeloma 23.3 7 16409727 (3), 15657181 (1), 17889702 (1)
    tumors 22.4 70 20101235 (3), 10200298 (2), 11355310 (2), 12438277 (2) (see all 43)

    Genetic Association Database (GAD): NTRK2
    Human Genome Epidemiology (HuGE) Navigator: NTRK2 (44 documents)
    Tumor Gene Database (TGDB): NTRK2

    Export disorders for NTRK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTRK2 gene, integrated from 9 sources (see all 657):
    (articles sorted by number of sources associating them with NTRK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2). (PubMed id 7789988)1, 2, 3, 9 Nakagawara A.... Brodeur G.M. (1995)
    2. Gene-gene interactions of the brain-derived neurotrop hic-factor and neurotrophic tyrosine kinase receptor 2 genes in geriatric depre ssion. (PubMed id 20014955)1, 4, 9 Lin E....Tsai S.J. (2009)
    3. Genetic analysis of the TrkB gene and schizophrenia in the Japanese population: Juntendo University Schizophrenia Projects (JUSP). (PubMed id 17720314)1, 4, 9 Higashi M....Arai H. (2007)
    4. Genetic association of neurotrophic tyrosine kinase receptor type 2 (NTRK2) With Alzheimer's disease. (PubMed id 17918233)1, 4, 9 Chen Z....Go R.C. (2008)
    5. Gene-Gene Interactions Among CHRNA4, CHRNB2, BDNF, and NTRK2 in Nicotine Dependence. (PubMed id 18534558)1, 4, 9 Li M.D....Elston R.C. (2008)
    6. Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, harm avoidance and minimum body mass index. (PubMed id 15838534)1, 4, 9 Ribases M....Estivill X. (2005)
    7. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant r esponse in Mexican-Americans. (PubMed id 19844206)1, 4, 9 Dong C....Licinio J. (2009)
    8. Extensive genotyping of the BDNF and NTRK2 genes define protective haplotypes against obsessive-compulsive disorder. (PubMed id 17884018)1, 4, 9 Alonso P....Estivill X. (2008)
    9. Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. (PubMed id 18293376)1, 2, 9 Marchetti A.... Buttitta F. (2008)
    10. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. (PubMed id 15494731)1, 2, 9 Yeo G.S....Farooqi I.S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4915 HGNC: 8032 AceView: NTRK2 Ensembl:ENSG00000148053 euGenes: HUgn4915
    ECgene: NTRK2 Kegg: 4915 H-InvDB: NTRK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTRK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NTRK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NTRK2 gene:
    Search GeneIP for patents involving NTRK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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