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NTRK2 Gene

protein-coding GIFtS: 71

GC09P086473

neurotrophic tyrosine kinase, receptor, type 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 2.7.10.1 ^³
GP145-TrkB ^², ³
OTTHUMP00000021573 ^²
OTTHUMP00000021574 ^²
OTTHUMP00000021575 ^²
OTTHUMP00000021576 ^²
OTTHUMP00000021577 ^²
TRKB ^¹, ², ³, ⁵
Trk-B ^³

Descriptions
BDNF/NT-3 growth factors receptor ^²
Neurotrophic tyrosine kinase receptor type 2 ^³
TrkB tyrosine kinase ^³
neurotrophic tyrosine kinase, receptor, type 2 ^²
tyrosine kinase receptor B ^²

External Ids
HGNC: 8032¹
Entrez Gene: 4915²
UniProtKB: Q16620³
Ensembl: ENSG00000148053⁷

Search outside databases for aliases for NTRK2 gene

Previous GC identifers: GC09P078328 GC09P079138 GC09P080839 GC09P082741 GC09P084514

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for NTRK2:

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase

is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of

the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this

gene have been associated with obesity and mood disorders. Alternate transcriptional splice

variants encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620

Function: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and

neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance

of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK

receptors are SHC1, PI-3 kinase, and PLC-gamma-1

Gene Wiki entry for NTRK2 (TrkB)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the NTRK2 gene

Entrez Gene cytogenetic band: 9q22.1 Ensembl cytogenetic band: 9q21.33 HGNC cytogenetic band: 9q22.1

NTRK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P086473: (about GC identifiers)

Start:	86,473,286 bp from pter
End:	86,828,325 bp from pter
Size:	355,040 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_023935.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620 (See protein sequence)

Recommended Name: BDNF/NT-3 growth factors receptor precursor

Size: 822 amino acids; 91999 Da

Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high

affinity) structures. Binds SH2B2. Interacts with SQSTM1 and KIDINS220 (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structure from and Proteopedia :

1HCF (3D)

1WWB (3D)

Secondary accessions: Q16675 Q8WXJ6

Alternative splicing: 3 isoforms: Q16620-1 Q16620-2 Q16620-3 (Additional isoforms seem to exist)

Post-translational modifications:

Ligand-mediated auto-phosphorylation¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_001007098.1 NP_001018074.1 NP_001018075.1 NP_001018076.1 NP_006171.2

ENSEMBL proteins:

ENSP00000352906 ENSP00000365381 ENSP00000379207 ENSP00000379221 ENSP00000306167 ENSP00000379211

ENSP00000314586 ENSP00000365385 ENSP00000277120 ENSP00000365387 ENSP00000365386

Human Recombinant Proteins

	Invitrogen human recombinant proteins for NTRK2
	Millipore Purified and/or Recombinant NTRK2 Protein
	Sigma-Aldrich Proteins for NTRK2
	R&D Systems Recombinant & Natural Proteins for NTRK2 (TrkB)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TRKA+B, TrkB, Pan Trk)
	Human Recombinant Proteins from Abnova (NTRK2)

OriGene Purified Recombinant Human Proteins (see all 2): NTRK2

5/12 Gene Ontology (GO) cellular component terms (links to tree view) (see all 12 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	1710174
GO:0009986	cell surface	IEA	--
GO:0014069	postsynaptic density	IEA	--

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Antibodies for NTRK2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of NTRK2
	Sigma-Aldrich Antibodies for NTRK2
	R&D Systems Antibodies for NTRK2 (TrkB)
	Cell Signaling Technology (CST) Antibodies for NTRK2 (TrkB)
	Antibodies from Abcam (TRKA+B, TrkB, Pan Trk), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (NTRK2)
	Novus Biologicals Antibodies for NTRK2

Assays for NTRK2:

	Invitrogen Assays for NTRK2
	Millipore Kits and Assays for the Analysis of NTRK2
	R&D Systems ELISAs for NTRK2 (TrkB) (see all)
	Cell Signaling Technology (CST) Sandwich ELISA Kits for NTRK2 (TrkB)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q16620

ProtoNet protein and cluster: Q16620

5 Blocks protein families:

IPB000372 Cysteine-rich flanking region

IPB000483 Cysteine-rich flanking region

IPB002011 Receptor tyrosine kinase

IPB003598 Immunoglobulin C-2 type

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor

subfamily

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 2 LRR (leucine-rich) repeats

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NTRK2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NTRK2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001007097

Applied Biosystems Silencer® siRNAs for NTRK2

Sigma-Aldrich siRNA and siRNA Panels for NTRK2

Sigma-Aldrich shRNA Panels and shRNA for NTRK2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for NTRK2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001007097
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001007097
untagged cDNA clones in CMV expression vector (see all 5): NM_001007097

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006180

UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620

Function: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and

neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance

of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK

receptors are SHC1, PI-3 kinase, and PLC-gamma-1

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.1

Genatlas biochemistry entry for NTRK2:

receptor tyrosine kinase B,linking brain derived neurotrophic factor (BDNF),neurotrophin (NTF4)

12 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Ntrk2):

behavior/neurological	endocrine/exocrine gland	growth/size	hearing/vestibular/ear	homeostasis/metabolism
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system	normal
reproductive system	vision/eye

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004714	transmembrane receptor protein tyrosine kinase activity	IEA	--
GO:0005030	neurotrophin receptor activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/6 Sigma-Aldrich "Your Favorite Gene" Pathways for NTRK2 (Your Favorite Gene powered by Ingenuity) (see all 6 )

CDK5 Signaling
Human Embryonic Stem Cell Pluripotency
Neurotrophin/TRK Signaling
Thyroid Cancer Signaling
Neuropathic Pain Signaling In Dorsal Horn Neurons

GeneDecks NTRK2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for NTRK2

5/64 Interacting proteins for NTRK2 (ENSP00000365387³) via UniProtKB, MINT, and/or STRING (see all 64 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BDNF	ENSP00000320002³	STRING (score=.999)
NGFR	ENSP00000172229³	STRING (score=.999)
NTF3	ENSP00000328738³	STRING (score=.999)
NTF4	ENSP00000301411³	STRING (score=.999)
GIPC1	ENSP00000340698³	STRING (score=.998)

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5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001570	vasculogenesis	IEA	--
GO:0007190	activation of adenylate cyclase activity	EXP	16805430
GO:0007275	multicellular organismal development	IEA	--
GO:0007399	nervous system development	IEA	--
GO:0007631	feeding behavior	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for NTRK2 available from Tocris Bioscience

Compound	Action	CAS number
BDNF (human)	Activates TrkB and p75 receptors	[218441-99-7]

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10/23 Novoseek chemical compound relationships for NTRK2 gene (see all 23 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	82.72	303	14581459 (5), 7671810 (3), 11432792 (3), 11095525 (3) (see all 99)
lestaurtinib	78.74	1	17611677 (1)
liga 20	68.10	3	12388556 (1), 16477610 (1)
phosphatidylinositol	40.73	7	12438277 (2), 15169782 (1), 18201274 (1), 15781614 (1) (see all 5)
pd 98,059	30.82	1	12438277 (1)
phosphotyrosine	20.39	2	18590375 (1), 8632056 (1)
matrigel	17.46	1	19087522 (1)
phenylalanine	14.57	2	10196222 (1)
quinolinic acid	8.72	1	11716553 (1)
threonine	5.54	1	9579409 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (NTRK2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (NTRK2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_001007097

Sigma-Aldrich siRNA and siRNA Panels for NTRK2

Sigma-Aldrich shRNA Panels and shRNA for NTRK2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001007097 NM_001018064 NM_001018065 NM_001018066 NM_006180

REFSEQ mRNAs for NTRK2 gene (5 alternative transcripts):

NM_001007097.1 NM_001018064.1 NM_001018065.2 NM_001018066.2 NM_006180.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001007097 NM_001018064 NM_001018065 NM_001018066 NM_006180

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001007097
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001007097
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001007097

Additional cDNA sequence:

AB209118.1 AF086101.1 AF400441.1 AF410898.1 AF410899.1 AF410900.1 AF410901.1 AF508964.1

AJ420458.1 AK092267.1 AK123824.1 AK289904.1 AK294285.1 AL713745.1 AL833196.1 BC031309.2

BC031835.1 BC075804.1 BX649001.1 S76473.1 S76474.1 U12140.1 X75958.1

24/25 DOTS entries (see all 25 ):

DT.91747295 DT.448703 DT.121204490 DT.100740853 DT.214737 DT.121204472 DT.121204415 DT.97844809

DT.410237 DT.121204487 DT.91932613 DT.92029358 DT.100815740 DT.121204437 DT.121204432 DT.121204436

DT.95148701 DT.100735567 DT.100815737 DT.100735568 DT.121204427 DT.121204451 DT.121204492 DT.91746504

24/292 AceView cDNA sequences (see all 292 ):

F02789 AF410898 BM931197 F11078 AF410900 BQ575614 AI857938 AI081305

AL708131 CK824574 AI654620 AW770836 AW292267 AL833196 AF410901 AI655270

AI880198 AA041195 AL603196 AA041432 AK092267 R20491 AA347011 BM263376

highest scoring ESTs for NTRK2:

U12140 AF400441 AF410899 AI018523 AI346341 AW950822 BX649001 H08619 S76473 T08952

Unigene Cluster for NTRK2:

Neurotrophic tyrosine kinase, receptor, type 2

Hs.494312 [show with all ESTs]

Unigene Representative Sequence: NM_001018065

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NTRK2 (see all 10 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	·	5c	·	5d	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^
SP1:													-		-																														-				-
SP2:													-		-																														-		-		-
SP3:																																													-		-		-
SP4:													-		-																														-				-
SP5:													-		-																														-		-		-

ExUns:	20	^	21	^	22	^	23a	·	23b	^	24	^	25	^	26a	·	26b
SP1:	-								-		-
SP2:	-
SP3:	-								-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for NTRK2

11 Ensembl transcripts including schematic representations:

ENST00000359847 ENST00000376208 ENST00000395866 ENST00000395882 ENST00000304053 ENST00000395870

ENST00000323115 ENST00000376212 ENST00000277120 ENST00000376214 ENST00000376213

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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NTRK2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for NTRK2

¹ / ² / ³

22 probe-sets matching NTRK2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1354_at²^{, 3}	U95-A	1	1.00	1.00	-0.17	0.87	U12140	1.00	1.00	1.00	1
38280_s_at²^{, 3}	U95-A	1	1.00	1.00	0.93	0.98	W28432	0.60	1.00	0.82	1
1355_g_at²^{, 3}	U95-A	1	1.00	1.00	0.18	0.76	U12140	1.00	1.00	1.00	1
62942_at²^{, 3}	U95-C	1	1.00	1.00	0.91	1.52	AI346341	0.80	1.00	0.91	1
36042_at²^{, 3}	U95-A	1	1.00	1.00	0.84	0.67	X75958	0.80	1.00	0.91	1
33182_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.34	AI018523	0.80	1.00	0.91	1
47469_at²^{, 3}	U95-B	1	1.00	1.00	0.93	0.89	AI654620	0.60	1.00	0.82	1
45522_at²^{, 3}	U95-B	1	0.94	1.00	0.92	1.62	R41958	0.40	1.00	0.76	1
60443_at²^{, 3}	U95-C	1	0.88	1.00	0.89	1.21	N75139	0.60	1.00	0.82	1
85052_at²^{, 3}	U95-E	1	0.56	1.00	0.53	0.67	H08619	0.80	1.00	0.91	1
214680_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF674712	0.60	1.00	0.82	1
207152_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006180	0.60	1.00	0.82	1
236095_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE858459	0.60	1.00	0.82	1
221796_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA707199	0.60	1.00	0.82	1
229463_at²^{, 3}	U133-B	1	1.00	1.00	--	--	R39159	0.40	1.00	0.76	1
221795_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI346341	0.80	1.00	0.91	1
214680_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207152_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
236095_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221796_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
229463_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221795_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks NTRK2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCTGTTTTT

SOURCE GeneReport for Unigene cluster: Hs.494312
Expression variation in blood from EXPOLDB for NTRK2
UniProtKB/Swiss-Prot: NTRK2_HUMAN, Q16620
Tissue specificity: Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS,
expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular
layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is
expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial
structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in
multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly
expressed in brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NTRK2 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NTRK2¹	--	neurotrophic tyrosine kinase, receptor, type 2	92.74(n) 98.3(a)	484147 XM_851329.1 XP_856422.1
chimpanzee (Pan troglodytes)	NTRK2¹	--	neurotrophic tyrosine kinase, receptor, type 2	99.55(n) 100(a)	735394 XM_001135401.1 XP_001135401.1
cow (Bos taurus)	NTRK2¹	--	neurotrophic tyrosine kinase, receptor, type 2	91.9(n) 93.12(a)	505824 NM_001075225.1 NP_001068693.1
rat (Rattus norvegicus)	Ntrk2¹	--	neurotrophic tyrosine kinase, receptor, type 2	87.58(n) 93.67(a)	25054 NM_012731.1 NP_036863.1
mouse (Mus musculus)	Ntrk2^{1, 5}	13 (36.00 cM)⁵	neurotrophic tyrosine kinase, receptor, type 2^{1, 5}	87.62(n)¹ 94.03(a)¹	18212¹ NM_001025074.1¹ NP_001020245.1¹ AB377224⁵ AB377225⁵ (see all 25)

About this table Species with no ortholog for NTRK2

ENSEMBL Gene Tree for NTRK2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NTRK2 gene

MUSK² NTRK1² NTRK3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1906 NCBI SNPs in NTRK2 are shown (see all 1906 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 669)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2013566^1,2	A,C,F,H,O	86616118(+)	`ATTTAA/GGTTAG`	5	--	int¹ ut3¹		12	MN NA EU EA WA	1166
	rs1187321^1,2	A,C,F,H,O	86472851(+)	`TAATAA/TTTAAC`	5	--	ng5¹ tfbs³		9	MN EU EA WA	1020
	rs1490403^1,2	A,C,F,H,O	86828326(-)	`TTTTTT/AAAATC`	2	--	ng3¹		15	EU EA WA NA	1336
	rs1624327^1,2	A,C,F,H,O	86619110(-)	`CATTAC/TGCTCT`	5	--	int¹ ut3¹ ese³		10	MN EA EU WA NA	2460
	rs7816^1,2	A,C,F,H	86620341(-)	`TAAAAT/ATTTTT`	5	--	ut3¹ int¹		5	MN EU EA WA	602
	rs10780691^1,2	A,C,F,H	86681073(+)	`GATGGC/TACCAC`	4	--	int¹ ut3¹ ese³		8	NA EA EU WA	774
	rs3780634^1,2	A,C,F,H	86678538(+)	`CACCCA/GAGTAT`	4	--	int¹ ut3¹ ese³		5	EA EU WA	1344
	rs1212171^1,2	A,C,F,H	86472347(+)	`TTAGAT/CTCTTC`	4	--	ng5¹		12	EU EA WA NA	2578
--	rs9969765^1,2	A,C,F,H	86679605(+)	`GACTGC/GAATGA`	4	--	int¹ ut3¹ ese³		4	EU EA WA	412
	rs3739570^1,2	A,C,F,H	86827398(-)	`AGTGTC/TTGCAC`	2	--	ut3¹ ese³		13	EA EU WA NA	2516

About this table

HapMap Linkage Disequilibrium images for NTRK2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600456

10/48 Novoseek disease relationships for NTRK2 gene (see all 48 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sensory neuropathy hereditary	51.81	1	8895241 (1)
neurodegenerative diseases	43.80	1	9692719 (1)
medulloblastoma	37.39	5	9560008 (2), 10994550 (1), 8774147 (1)
ganglioneuroma	36.42	3	8264643 (1), 10217562 (1)
dysautonomia familial	35.90	4	7759111 (2), 8895241 (1)
ganglioglioma	32.14	1	9625303 (1)
alzheimers disease	32.04	13	15726264 (2), 17069877 (1), 8931004 (1), 16023301 (1) (see all 8)
tumors	21.05	62	10200298 (2), 11355310 (2), 12438277 (2), 8264643 (2) (see all 38)
wilms tumor	19.10	3	11528553 (1), 17008023 (1)
myeloma	17.50	7	16409727 (3), 15657181 (1), 17889702 (1)

About this table

Human Gene Mutation Database: NTRK2
Genetic Association Database: NTRK2
Human Genome Epidemiology Navigator: NTRK2 (21 documents)
Tumor Gene Database: NTRK2

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/500 PubMed articles for NTRK2 gene (see all 500 ):

Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2). (PubMed id 7789988)^{1, 2, 3, 4} Nakagawara A.... Brodeur G.M. (1995)
Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, harm avoidance and minimum body mass index. (PubMed id 15838534)^{1, 3, 6} Ribases M....Estivill X. (2005)
Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain. (PubMed id 7936202)^{1, 3, 4} Allen S.J.... Macgowan S.H. (1994)
Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung. (PubMed id 18293376)^{1, 3, 4} Marchetti A.... Buttitta F. (2008)
Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC. (PubMed id 10388563)^{1, 3, 4} Ultsch M.H.... de Vos A.M. (1999)
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. (PubMed id 7823156)^{1, 3, 4} Shelton D.L.... Levinson A.D. (1995)
Association study of neurotrophic tyrosine kinase receptor type 2 (NTRK2) and childhood-onset mood disorders. (PubMed id 15389758)^{3, 6} Adams J.H....Barr C.L. (2005)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Analysis of the human TrkB gene genomic organization reveals novel TrkB isoforms, unusual gene length, and splicing mechanism. (PubMed id 11798182)^{3, 4} Stoilov P.... Stamm S. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 4915	HGNC: 8032	AceView: NTRK2	Ensembl:ENSG00000148053	euGenes: HUgn4915
ECgene: NTRK2	H-InvDB: NTRK2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for NTRK2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for NTRK2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for NTRK2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for NTRK2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NTRK2		Antibodies for NTRK2
	Explore super-pooled esiRNAs		Proteins for NTRK2
	Lentivirus-delivered shRNAs for NTRK2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (NTRK2)
	Antibodies (NTRK2)
	Chimera RNAi (NTRK2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for NTRK2 (TrkB)

	Recombinant Proteins (TRKA+B, TrkB, Pan Trk)
	Antibodies (TRKA+B, TrkB, Pan Trk)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Tocris compounds for NTRK2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for NTRK2

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NTRK2 Gene

protein-coding GIFtS: 71

Aliases &
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for NTRK2

Summaries
for NTRK2

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for NTRK2

Proteins
for NTRK2

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for NTRK2

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for NTRK2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

NTRK2 Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor NTRK2

Summariesfor NTRK2

Genomic Locationfor NTRK2

Proteinsfor NTRK2

Protein Domains/Familiesfor NTRK2

Gene Functionfor NTRK2

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Genome Databases showing NTRK2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for NTRK2

Summaries
for NTRK2

Genomic Location
for NTRK2

Proteins
for NTRK2

Protein Domains/
Families
for NTRK2

Gene Function
for NTRK2

Pathways & Interactions
for NTRK2

Drugs & Compounds
for NTRK2

Transcripts
for NTRK2

Expression
for NTRK2

Orthologs
for NTRK2

Paralogs
for NTRK2

SNPs/Variants
for NTRK2

Disorders & Mutations
for NTRK2

Medical News
for NTRK2

Publications
for NTRK2

Licensable Technologies
for NTRK2

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for NTRK2