Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NTRK1 Gene

protein-coding GIFtS: 76
GCID: GC01P156786

neurotrophic tyrosine kinase, receptor, type 1

Explore 116 diseases affiliated with
NTRK1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neurotrophic Tyrosine Kinase, Receptor, Type 1¹ ²		TRK1-Transforming Tyrosine Kinase Protein² ³
MTC¹ ² ³ ⁵		EC 2.7.10.1³ ⁸
TRKA¹ ² ³ ⁵		TRK1²
TRK¹ ² ³		High Affinity Nerve Growth Factor Receptor²
Tropomyosin-Related Kinase A² ³		Oncogene TRK²
Tyrosine Kinase Receptor A² ³		Neurotrophic Tyrosine Kinase Receptor Type 1³
Trk-A² ³		Tyrosine Kinase Receptor³
Gp140trk¹		EC 2.7.10⁸
P140-TrkA¹

External Ids:	HGNC: 8031¹	Entrez Gene: 4914²	Ensembl: ENSG00000198400⁷	OMIM: 191315⁵	UniProtKB: P04629³

Export aliases for NTRK1 gene to outside databases

Previous GC identifers: GC01P154699 GC01P152595 GC01P153609 GC01P154047 GC01P153643 GC01P155052 GC01P128143

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTRK1:

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound

receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this

kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene

have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation

and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been

characterized to date. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NTRK1_HUMAN, P04629

Function: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous

systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High

affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3.

However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF

ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or

activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping

signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade

that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription

of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is

also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons

dependent on trophic factors

Function: Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate

the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal

precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed

summary for NTRK1:

Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase

activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling

pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.

p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds

different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is

involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in

neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is

involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by

neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors

with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as

an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NTRK1 (TrkA receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NTRK1 gene promoter:
c-Fos CREB p53 AP-1 deltaCREB ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NTRK1 promoter sequence

Search SABiosciences Chromatin IP Primers for NTRK1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTRK1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q21-q22

NTRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTRK1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P156786: view genomic region (about GC identifiers)

Start:	156,785,432 bp from pter	End:	156,851,642 bp from pter
Size:	66,211 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NTRK1_HUMAN, P04629 (See protein sequence)

Recommended Name: High affinity nerve growth factor receptor precursor

Size: 796 amino acids; 87497 Da

Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures.

Homodimerization is induced by binding of a NGF dimer. Interacts with SQSTM1; bridges NTRK1 to NGFR. Forms a ternary

complex with NGFR and KIDINS220; this complex is affected by the expression levels of KIDINS220 and an increase in

KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts with SH2D1A;

regulates NTRK1 (By similarity). Interacts (phosphorylated upon activation by NGF) with SHC1; mediates SHC1

phosphorylation and activation. Interacts (phosphorylated upon activation by NGF) with PLCG1; mediates PLCG1

phosphorylation and activation. Interacts (phosphorylated) with SH2B1 and SH2B2. Interacts with GRB2. Interacts with

PIK3R1. Interacts with FRS2. Interacts with SORT1; may regulate NTRK1 anterograde axonal transport. Interacts with

RAB7A (By similarity)

Subcellular location: Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I

membrane protein (By similarity). Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported

to the cell body via a retrograde axonal transport (By similarity)

Miscellaneous: Trk also stands for tropomyosin-related kinase since it was first isolated as an oncogenic protein which

was the result of a fusion between the tropomyosin gene TPM3 and NTRK1

Sequence caution: Sequence=CAA27243.1; Type=Erroneous termination; Positions=786; Note=Translated as Gln;

Sequence=CAA27243.1; Type=Frameshift; Positions=769; Sequence=CAA27243.1; Type=Miscellaneous discrepancy;

Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=CAA29888.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;

Sequence=CAA44719.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the

N-terminal part; Sequence=CAA59936.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown

origin in the N-terminal part;

6/8 PDB 3D structures from and Proteopedia for NTRK1 (see all 8):

1HE7 (3D)

1SHC (3D)

1WWA (3D)

1WWW (3D)

2IFG (3D)

4AOJ (3D)

Secondary accessions: B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7

Alternative splicing: 4 isoforms: P04629-1 P04629-2 P04629-3 P04629-4 (Constitutively active. Does not bind NGF and does not interact with GRB2 and FRS2)

Explore the universe of human proteins at neXtProt for NTRK1: NX_P04629

Post-translational modifications:

Ligand-mediated autophosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at

Tyr-496 mediates interaction and phosphorylation of SHC1¹

N-glycosylated (Probable). Isoform TrkA-I is N-glycosylated¹

Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the

internalization of the receptor (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P04629

4/14 DME Specific Peptides for NTRK1 (P04629) (see all 14)

FVHRDLA

RRDIVLK

GVVLWEI

HHWCIPF

NTRK1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001007793.1 NP_001012331.1 NP_002520.2

ENSEMBL proteins:

ENSP00000376120 ENSP00000436804 ENSP00000357179 ENSP00000431418 ENSP00000351486

Reactome Protein details: P04629
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant NTRK1 Protein
	R&D Systems Recombinant & Natural Proteins for NTRK1 (TrkA)
	Enzo Life Sciences proteins for NTRK1
	OriGene Purified Protein: NTRK1 OriGene Protein Over-expression Lysate (see all 3): NTRK1 OriGene Custom Protein Services for NTRK1
	GenScript Custom Purified and Recombinant Proteins Services for NTRK1
	Novus Biologicals NTRK1 Proteins Novus Biologicals NTRK1 Lysates
	Sino Biological Recombinant Protein for NTRK1
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NTRK1

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000139	Golgi membrane	--	--
GO:0005737	cytoplasm	--	--
GO:0005768	endosome	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	IDA	15488758

NTRK1 for ontologies About GeneDecksing

NTRK1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NTRK1
	R&D Systems Antibodies for NTRK1 (TrkA)
	Cell Signaling Technology (CST) Antibodies for NTRK1 (TrkA)
	OriGene Antibodies (see all 4): NTRK1 OriGene Custom Antibody Services for NTRK1
	GenScript Superior Antibodies for NTRK1
	Novus Biologicals NTRK1 Antibodies
	Abcam antibodies for NTRK1
	Uscn Antibodies for NTRK1
	ThermoFisher Antibody for NTRK1

Assay Products for NTRK1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for NTRK1 (TrkA) (see all)
	GenScript Custom Assay Services for NTRK1
	Cell Signaling Technology (CST) Sandwich ELISA Kits for NTRK1 (TrkA)
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NTRK1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NTRK1 for domains About GeneDecksing

5/13 InterPro domains/families (see all 13):

IPR007110 Ig-like_dom

IPR017441 Protein_kinase_ATP_BS

IPR000483 Cys-rich_flank_reg_C

IPR003599 Ig_sub

IPR001245 Ser-Thr/Tyr_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry P04629

ProtoNet protein and cluster: P04629

4 Blocks protein families:

IPB000483 Cysteine-rich flanking region

IPB002011 Receptor tyrosine kinase

IPB003599 Immunoglobulin subtype

IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: NTRK1_HUMAN, P04629

Domain: The transmembrane domain mediates interaction with KIDINS220 (By similarity)

Domain: The extracellular domain mediates interaction with NGFR (By similarity)

Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 2 LRR (leucine-rich) repeats

Similarity: Contains 1 LRRCT domain

Similarity: Contains 1 protein kinase domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: