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NTRK1 Gene

protein-coding   GIFtS: 77
GCID: GC01P156786

Neurotrophic Tyrosine Kinase, Receptor, Type 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Neurotrophic Tyrosine Kinase, Receptor, Type 11 2     p140-TrkA2 3
MTC2 3 5     TRK1-Transforming Tyrosine Kinase Protein2 3
TRKA2 3 5     EC 2.7.10.13 8
High Affinity Nerve Growth Factor Receptor1 2     TRK12
Tropomyosin-Related Kinase A2 3     Oncogene TRK2
Tyrosine Kinase Receptor A2 3     Neurotrophic Tyrosine Kinase Receptor Type 13
TRK2 3     Tyrosine Kinase Receptor3
Trk-A2 3     EC 2.7.108
gp140trk2 3     

External Ids:    HGNC: 80311   Entrez Gene: 49142   Ensembl: ENSG000001984007   OMIM: 1913155   UniProtKB: P046293   
ORGUL members:         

Export aliases for NTRK1 gene to outside databases

Previous GC identifers: GC01P154699 GC01P152595 GC01P153609 GC01P154047 GC01P153643 GC01P155052 GC01P128143


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NTRK1 Gene:
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a
membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.
The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron
subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis,
self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene
have been found, but only three have been characterized to date. (provided by RefSeq, Jul 2008)

GeneCards Summary for NTRK1 Gene:
NTRK1 (neurotrophic tyrosine kinase, receptor, type 1) is a protein-coding gene. Diseases associated with NTRK1 include familial medullary thyroid carcinoma, and anhidrosis. GO annotations related to this gene include ephrin receptor binding and protein homodimerization activity. An important paralog of this gene is ROR1.

UniProtKB/Swiss-Prot: NTRK1_HUMAN, P04629
Function: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral
nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous
neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by
NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron
survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation.
Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and
PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through
SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1
controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1
controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and
activation, may promote cell death, making the survival of neurons dependent on trophic factors
Function: Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to
activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes
neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when
overexpressed

summary for NTRK1 Gene:
Trk (neurotrophin) receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase
activity. Trk receptors are coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI 3-K and PLCgamma signaling
pathways. There are four members of the Trk family; TrkA, TrkB and TrkC and a related p75NTR receptor.
p75NTR lacks tyrosine kinase activity and signals via NF-kappaB activation. Each family member binds
different neurotrophins with varying affinities. TrkA potently binds nerve growth factor (NGF) and is
involved in differentiation and survival of neurons and in control of gene expression of enzymes involved in
neurotransmitter synthesis. TrkB has highest affinity for brain-derived neurotrophic factor (BDNF) and is
involved in neuronal plasticity, longterm potentiation and apoptosis of CNS neurons. TrkC is activated by
neurotrophin-3 (NT-3) and is found on proprioceptive sensory neurons. p75NTR binds neurotrophin precursors
with high affinity and retains low affinity to the mature cleaved forms. TrkA was originally identified as
an oncogene as it is commonly mutated in cancers, particularly colon and thyroid carcinomas.

Gene Wiki entry for NTRK1 (TrkA receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the NTRK1 gene promoter:
         c-Fos   CREB   p53   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NTRK1 promoter sequence
   Search Chromatin IP Primers for NTRK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTRK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21-q22

NTRK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTRK1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P156786:  view genomic region     (about GC identifiers)

Start:
156,785,432 bp from pter      End:
156,851,642 bp from pter
Size:
66,211 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NTRK1_HUMAN, P04629 (See protein sequence)
Recommended Name: High affinity nerve growth factor receptor precursor  
Size: 796 amino acids; 87497 Da
Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures.
Homodimerization is induced by binding of a NGF dimer. Interacts with SQSTM1; bridges NTRK1 to NGFR. Forms a
ternary complex with NGFR and KIDINS220; this complex is affected by the expression levels of KIDINS220 and an
increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity). Interacts
with SH2D1A; regulates NTRK1 (By similarity). Interacts (phosphorylated upon activation by NGF) with SHC1;
mediates SHC1 phosphorylation and activation. Interacts (phosphorylated upon activation by NGF) with PLCG1;
mediates PLCG1 phosphorylation and activation. Interacts (phosphorylated) with SH2B1 and SH2B2. Interacts with
GRB2. Interacts with PIK3R1. Interacts with FRS2. Interacts with SORT1; may regulate NTRK1 anterograde axonal
transport. Interacts with RAB7A (By similarity). Found in a complex, at least composed of KIDINS220, MAGI2, NTRK1
and RAPGEF2; the complex is mainly formed at late endosomes in a nerve growth factor (NGF)-dependent manner (By
similarity). Interacts with RAPGEF2; the interaction is strengthened after NGF stimulation (By similarity)
Miscellaneous: Trk also stands for tropomyosin-related kinase since it was first isolated as an oncogenic protein
which was the result of a fusion between the tropomyosin gene TPM3 and NTRK1
Sequence caution: Sequence=CAA27243.1; Type=Erroneous termination; Positions=786; Note=Translated as Gln;
Sequence=CAA27243.1; Type=Frameshift; Positions=769; Sequence=CAA27243.1; Type=Miscellaneous discrepancy;
Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=CAA29888.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
Sequence=CAA44719.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in
the N-terminal part; Sequence=CAA59936.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence
of unknown origin in the N-terminal part;
Selected PDB 3D structures from and Proteopedia for NTRK1 (see all 8):
1HE7 (3D)        1SHC (3D)        1WWA (3D)        1WWW (3D)        2IFG (3D)        4AOJ (3D)    
Secondary accessions: B2R6T5 B7ZM34 P08119 Q15655 Q15656 Q5D056 Q5VZS2 Q7Z5C3 Q9UIU7
Alternative splicing: 4 isoforms:  P04629-1   P04629-2   P04629-3   P04629-4   (Constitutively active. Does not bind NGF and does not interact with GRB2 and FRS2)

Explore the universe of human proteins at neXtProt for NTRK1: NX_P04629

Explore proteomics data for NTRK1 at MOPED

Post-translational modifications: 

  • Ligand-mediated autophosphorylation. Interaction with SQSTM1 is phosphotyrosine-dependent. Autophosphorylation at
    Tyr-496 mediates interaction and phosphorylation of SHC11
  • N-glycosylated (Probable). Isoform TrkA-I is N-glycosylated1
  • Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the
    internalization of the receptor (By similarity)1
  • Glycosylation2 at Asn67, Asn95, Asn121, Asn188, Asn202, Asn253, Asn262, Asn281, Asn318, Asn323,
                                 Asn338, Asn358, Asn401
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for NTRK1 (P04629) (see all 14)
     FVHRDLA  RRDIVLK  GVVLWEI  HHWCIPF 


    See NTRK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001007793.1  NP_001012331.1  NP_002520.2  

    ENSEMBL proteins: 
     ENSP00000376120   ENSP00000436804   ENSP00000357179   ENSP00000431418   ENSP00000351486  
    Reactome Protein details: P04629

    NTRK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant NTRK1 Protein
    R&D Systems Recombinant & Natural Proteins for NTRK1 (TrkA)
    Enzo Life Sciences proteins for NTRK1
    OriGene Purified Protein for NTRK1
    OriGene Protein Over-expression Lysate for NTRK1
    OriGene MassSpec for NTRK1
    OriGene Custom Protein Services for NTRK1
    GenScript Purified and Recombinant Proteins for NTRK1
    Novus Biologicals NTRK1 Proteins
    Novus Biologicals NTRK1 Lysates
    Sino Biological Recombinant Protein for NTRK1
    Sino Biological Cell Lysate for NTRK1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NTRK1

    NTRK1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NTRK1
    R&D Systems Antibodies for NTRK1 (TrkA)
    Cell Signaling Technology (CST) Antibodies for NTRK1  (TrkA)
    OriGene Antibodies for NTRK1
    OriGene Custom Antibody Services for NTRK1
    Novus Biologicals NTRK1 Antibodies
    Abcam antibodies for NTRK1 (Q16288, P04629)
    Cloud-Clone Corp. Antibodies for NTRK1
    ThermoFisher Antibody for NTRK1
    LSBio Antibodies in human, mouse, rat for NTRK1

    NTRK1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NTRK1
    R&D Systems ELISAs for NTRK1 (TrkA)         (see all)
    GenScript Custom Assay Services for NTRK1
    Cell Signaling Technology (CST) Sandwich ELISA Kits for NTRK1 (TrkA)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NTRK1
    Cloud-Clone Corp. CLIAs for NTRK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: neurotrophic tyrosine kinase, receptor, type 1
    Neurotrophin receptor/Trk family

    Selected InterPro protein domains (see all 13):
     IPR007110 Ig-like_dom
     IPR017441 Protein_kinase_ATP_BS
     IPR000483 Cys-rich_flank_reg_C
     IPR003599 Ig_sub
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P04629

    ProtoNet protein and cluster: P04629

    4 Blocks protein domains:
    IPB000483 Cysteine-rich flanking region
    IPB002011 Receptor tyrosine kinase
    IPB003599 Immunoglobulin subtype
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: NTRK1_HUMAN, P04629
    Domain: The transmembrane domain mediates interaction with KIDINS220 (By similarity)
    Domain: The extracellular domain mediates interaction with NGFR (By similarity)
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 protein kinase domain


    NTRK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTRK1_HUMAN, P04629
    Function: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral
    nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous
    neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by
    NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron
    survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation.
    Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and
    PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through
    SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1
    controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1
    controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and
    activation, may promote cell death, making the survival of neurons dependent on trophic factors
    Function: Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to
    activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes
    neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when
    overexpressed
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: The pro-survival signaling effect of NTRK1 in neurons requires its endocytosis into signaling
    early endosomes and its retrograde axonal transport. This is regulated by different proteins including CFL1, RAC1
    and SORT1. NTF3 is unable to induce this signaling probably due to the lability of the NTF3-NTRK1 complex in
    endosomes. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of
    downstream effectors and signaling cascades (By similarity). Regulated by NGFR (By similarity)
    Induction: Isoform TrkA-III is up-regulated upon hypoxia in cells normally expressing it

         Genatlas biochemistry entry for NTRK1:
    receptor tyrosine kinase A,binding nerve growth factor (NGFA,NGFB,NGFC),with high affinity,involved in the
    survival differentiation and maintenance of many neural and non neural cell types

         Enzyme Numbers (IUBMB): EC 2.7.10.11 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004714transmembrane receptor protein tyrosine kinase activity IDA15488758
    GO:0005030neurotrophin receptor activity ----
    GO:0005166neurotrophin p75 receptor binding IEA--
         
    NTRK1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for NTRK1:
     Decreased substrate adherent c  Decreased telomerase activity  Upregulation of Wnt/beta-caten 

         14 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Ntrk1):
     behavior/neurological  growth/size/body  hearing/vestibular/ear  hematopoietic system  immune system 
     integument  limbs/digits/tail  mortality/aging  muscle  nervous system 
     no phenotypic analysis  normal  pigmentation  vision/eye 

    NTRK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NTRK1: Ntrk1tm1Tes Ntrk1tm1Par Ntrk1tm1Bbd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NTRK1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NTRK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTRK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTRK1

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat NTRK1 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate NTRK1:
    hsa-miR-920 hsa-miR-4300 hsa-miR-302f
    SwitchGear 3'UTR luciferase reporter plasmidNTRK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NTRK1
    Predesigned siRNA for gene silencing in human, mouse, rat NTRK1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NTRK1

    Clone
    Products:
         
    OriGene clones in human, mouse for NTRK1 (see all 16)
    OriGene ORF clones in mouse, rat for NTRK1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): NTRK1 (NM_001007792)
    Sino Biological Human cDNA Clone for NTRK1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTRK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTRK1

    Cell Line
    Products:
         
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    ESI BIO PureStem Progenitor for NTRK1: 
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTRK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NTRK1_HUMAN, P04629: Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass
    type I membrane protein (By similarity). Late endosome membrane; Single-pass type I membrane protein (By
    similarity). Note=Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body
    via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor
    (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPGEF2 at late endosomes
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    endosome5
    nucleus5
    plasma membrane5
    cytosol1
    extracellular1
    golgi apparatus1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005768endosome TAS--
    GO:0005769early endosome ISS--
    GO:0005770late endosome ISS--
    GO:0005886plasma membrane TAS--

    NTRK1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NTRK1 About   (see all 41)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Apoptosis and survival NGF signaling pathway0.36
    Apoptosis and survival Role of CDK5 in neuronal death and survival0.37
    Neurotrophin signaling pathway0.36
    2Neurotrophic factor-mediated Trk receptor signaling
    Neurotrophic factor-mediated Trk receptor signaling
    Signalling to STAT30.00
    TRKA activation by NGF0.00
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Actin-Based Motility by Rho Family GTPases0.62
    Apoptotic Pathways in Synovial Fibroblasts0.84
    ERK5 Signaling0.61
    p53 Mediated Apoptosis0.84
    eIF2 Pathway0.60
    5GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    P2Y Receptor Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NTRK1
        Akt Signaling Pathway

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NTRK1 (see all 57)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 Cell Signaling Technology (CST) Pathways for NTRK1
        Neuroscience
    Tyrosine Kinases / Adaptors

    3 Tocris Bioscience Pathways for NTRK1
        Akt Pathway
    Apoptosis Pathway
    NF-kappaB Pathway

    4 GeneGo (Thomson Reuters) Pathways for NTRK1
        Apoptosis and survival Role of CDK5 in neuronal death and survival
    Development Neurotrophin family signaling
    Apoptosis and survival NGF signaling pathway
    Development MAG-dependent inhibition of neurite outgrowth

    4 BioSystems Pathways for NTRK1
        MAPK signaling pathway
    BDNF signaling pathway
    Integrated Pancreatic Cancer Pathway
    Neurotrophic factor-mediated Trk receptor signaling


    Selected Reactome Pathways for NTRK1 (see all 10)
        PLC-gamma1 signalling
    Frs2-mediated activation
    Signalling to RAS
    Retrograde neurotrophin signalling
    Signalling to p38 via RIT and RIN


    Selected Kegg Pathways  (Kegg details for NTRK1) (see all 8):
        MAPK signaling pathway
    Endocytosis
    Apoptosis
    Neurotrophin signaling pathway
    Inflammatory mediator regulation of TRP channels


    NTRK1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NTRK1: 
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat
              Alzheimer's Disease in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NTRK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NTRK1 (P046291, 2, 3 ENSP000003514864) via UniProtKB, MINT, STRING, and/or I2D (see all 120)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLCG1P191742, 3, ENSP000002440074MINT-8026079 MINT-8026064 I2D: score=3 STRING: ENSP00000244007
    KIDINS220Q9ULH02, 3, ENSP000002567074MINT-7188184 I2D: score=3 STRING: ENSP00000256707
    CBLP226811, 2, 3, ENSP000002640334EBI-1028226,EBI-518228 MINT-8173312 MINT-8173327 I2D: score=2 STRING: ENSP00000264033
    PTPN1P180311, 2, 3, ENSP000003606834EBI-1028226,EBI-968788 MINT-6793925 MINT-6793941 I2D: score=4 STRING: ENSP00000360683
    SHC1P293532, 3, ENSP000004013034MINT-8030681 MINT-8030666 I2D: score=6 STRING: ENSP00000401303
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 49):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity TAS--
    GO:0006468protein phosphorylation IDA15488758
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS--
    GO:0007190activation of adenylate cyclase activity TAS--
    GO:0007202activation of phospholipase C activity TAS--

    NTRK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for NTRK1
      Browse compounds at ApexBio 

    Compounds for NTRK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BDNF (human)Activates TrkB and p75 receptors[218441-99-7]
    ANA 12TrkB receptor antagonist[219766-25-3]
    GNF 5837 Potent Trk inhibitor; inhibits TrkA, TrkB and TrkC [1033769-28-6]
    TLQP 21VGF-derived peptide[869988-94-3]
    7,8-Dihydroxyflavone TrkB agonist[38183-03-8]

    2 HMDB Compounds for NTRK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    3 DrugBank Compounds for NTRK1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    ImatinibCGP-57148B (see all 4)152459-95-5targetantagonist17582306 16782438 15832750 16052979 17579194
    AmitriptylineAmitriprolidine (see all 5)50-48-6targetagonist19549602
    Regorafenib-- 755037-03-7targetinhibitor--

    Selected Novoseek inferred chemical compound relationships for NTRK1 gene (see all 74)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cipa 89.1 70 8696348 (4), 11668614 (3), 19618435 (3), 11139246 (3) (see all 25)
    k252a 88.5 53 1312698 (5), 11698603 (2), 11997324 (2), 7712490 (1) (see all 38)
    tyrosine 86.4 529 9275225 (3), 1837350 (3), 1831195 (3), 1312698 (3) (see all 99)
    ag 879 74.7 6 16940803 (1), 18775707 (1), 16809450 (1), 11154856 (1)
    asp-glu 68.3 4 14647472 (2), 10656690 (1)
    lestaurtinib 60.1 10 17596848 (2), 17611677 (1)
    phosphotyrosine 56.2 9 8563936 (3), 9166727 (1), 10708759 (1), 15513915 (1) (see all 6)
    dephostatin 51.3 1 16027232 (1)
    ceramide 45 8 15264216 (3), 9295291 (2), 11359788 (1), 11916364 (1) (see all 5)
    ganglioside 43.1 11 11201795 (2), 9166727 (1), 9748278 (1), 15312164 (1) (see all 5)

    1 PharmGKB related drug/compound annotation for NTRK1 gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  



    NTRK1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for NTRK1 gene (3 alternative transcripts): 
    NM_001007792.1  NM_001012331.1  NM_002529.3  

    Unigene Cluster for NTRK1:

    Neurotrophic tyrosine kinase, receptor, type 1
    Hs.406293  [show with all ESTs]
    Unigene Representative Sequence: CR936794
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000489021 ENST00000392302(uc001fqf.1) ENST00000497019(uc009wsi.1)
    ENST00000530298 ENST00000368196(uc001fqh.1 uc001fqi.1 uc009wsk.1)
    ENST00000524377 ENST00000358660 ENST00000533630 ENST00000534682 ENST00000531606

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    Additional mRNA sequence: 

    AK126428.1 AK290759.1 AK312704.1 BC062580.1 BC136554.1 BC144239.1 CR936794.1 M23102.1 
    X03541.1 X06710.1 

    5 DOTS entries:

    DT.91758586  DT.100719720  DT.121451163  DT.101982089  DT.121451130 

    Selected AceView cDNA sequences (see all 28):

    CR625585 BC062580 CD673237 BM685020 BX389843 BG110843 AK126428 BX350284 
    BM931980 BX340144 NM_002529 BQ716999 BV199110 BM727488 BI758018 M23102 
    X06704 BX340145 AL563691 AU144696 AL557329 BG120028 X62947 X85960 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NTRK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NTRK1 Expression
    About this image


    NTRK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Epithelial Cells
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Eye (Sensory Organs)    fully expand to see all 4 entries
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    NTRK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NTRK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406293

    UniProtKB/Swiss-Prot: NTRK1_HUMAN, P04629
    Tissue specificity: Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed
    in neuronal cells. TrkA-III is specifically expressed by pluripotent neural stem and neural crest progenitors

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NTRK1: 
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat
              Alzheimer's Disease in human mouse rat
              Apoptosis 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NTRK1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntrk11 , 5 neurotrophic tyrosine kinase, receptor, type 11, 5 85.47(n)1
    87.28(a)1
      3 (38.62 cM)5
    182111  NM_001033124.11  NP_001028296.11 
     877782445 
    chicken
    (Gallus gallus)
    Aves NTRK11 neurotrophic tyrosine kinase, receptor, type 1 68.09(n)
    63.73(a)
      396337  NM_205378.1  NP_990709.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTRK16
    neurotrophic tyrosine kinase, receptor, type 1
    56(a)
    1 ↔ 1
    GL343640.1(3197-125548)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ntrk11 neurotrophic tyrosine kinase, receptor, type 1 62.23(n)
    61.06(a)
      100489637  XM_002938989.2  XP_002939035.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntrk11 neurotrophic tyrosine kinase, receptor, type 1 58.33(n)
    54.43(a)
      30546  XM_692154.5  XP_697246.5 
    worm
    (Caenorhabditis elegans)
    Secernentea trk-16
    Protein TRK-1, isoform a (trk-1) mRNA, complete cd...
    22(a)
    1 → many
    X(8940849-8950978) WBGene00017039


    ENSEMBL Gene Tree for NTRK1 (if available)
    TreeFam Gene Tree for NTRK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NTRK1 gene
    ROR12  INSR2  ROS12  NTRK22  LTK2  IGF1R2  DDR12  NTRK32  
    INSRR2  ROR22  DDR22  MUSK2  ALK2  
    Selected SIMAP similar genes for NTRK1 using alignment to 3 protein entries:     NTRK1_HUMAN (see all proteins) (see all similar genes):
    trk2    EPHA4    trk4    RET    ABL1    DDR1
    BTK    EPHA2    TXK    DKFZp434L0319    DKFZp686M05208    FLT4
    NTRK2    PTK7    tec    NTRK3    FGR    MET

    NTRK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NTRK1 (see all 1981)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0096264
    Congenital insensitivity to pain with anhidrosis (CIPA)4--see VAR_0096262 G R mis40--------
    VAR_0096244
    Congenital insensitivity to pain with anhidrosis (CIPA)4--see VAR_0096242 L P mis40--------
    VAR_0096304
    Congenital insensitivity to pain with anhidrosis (CIPA)4--see VAR_0096302 R W mis40--------
    VAR_0684814
    Congenital insensitivity to pain with anhidrosis (CIPA)4--see VAR_0684812 Y C mis40--------
    VAR_0041034
    Congenital insensitivity to pain with anhidrosis (CIPA)4--see VAR_0041032 G R mis40--------
    VAR_0096254
    Congenital insensitivity to pain with anhidrosis (CIPA)4--see VAR_0096252 L P mis40--------
    VAR_0096344
    Congenital insensitivity to pain with anhidrosis (CIPA)4--see VAR_0096342 G S mis40--------
    VAR_0096334
    Congenital insensitivity to pain with anhidrosis (CIPA)4--see VAR_0096332 P L mis40--------
    VAR_0096274
    Congenital insensitivity to pain with anhidrosis (CIPA)4--see VAR_0096272 M V mis40--------
    VAR_0414624
    An ovarian serous carcinoma sample4--see VAR_0414622 A V mis40--------

    HapMap Linkage Disequilibrium report for NTRK1 (156785432 - 156851642 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NTRK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718462CNV Deletion23290073
    esv1637866CNV Deletion17803354
    dgv49e201CNV Deletion23290073
    esv2718451CNV Deletion23290073
    esv1010343CNV Deletion20482838
    esv1001917CNV Deletion20482838
    nsv831659CNV Loss17160897
    nsv831648CNV Loss17160897

    Human Gene Mutation Database (HGMD): NTRK1
    Locus Specific Mutation Databases (LSDB): NTRK1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NTRK1
    DNA2.0 Custom Variant and Variant Library Synthesis for NTRK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191315   
    OMIM disorders: 256800  155240  
    UniProtKB/Swiss-Prot: NTRK1_HUMAN, P04629
  • Congenital insensitivity to pain with anhidrosis (CIPA) [MIM:256800]: Characterized by a congenital
    insensitivity to pain, anhidrosis (absence of sweating), absence of reaction to noxious stimuli, self-mutilating
    behavior, and mental retardation. This rare autosomal recessive disorder is also known as congenital sensory
    neuropathy with anhidrosis or hereditary sensory and autonomic neuropathy type IV or familial dysautonomia type
    II. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an
    irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm
    characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered
    with a surface layer of neoplastic epithelial cells. Note=The gene represented in this entry is involved in
    disease pathogenesis. Chromosomal aberrations involving NTRK1 are found in thyroid papillary carcinomas.
    Translocation t(1;3)(q21;q11) with TFG generates the TRKT3 (TRK-T3) transcript by fusing TFG to the 3'-end of
    NTRK1; a rearrangement with TPM3 generates the TRK transcript by fusing TPM3 to the 3'-end of NTRK1; an
    intrachromosomal rearrangement that links the protein kinase domain of NTRK1 to the 5'-end of the TPR gene forms
    the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the C-terminus of the
    NTRK1 protein

  • Selected diseases for NTRK1 (see all 120):    
    About MalaCards
    familial medullary thyroid carcinoma    anhidrosis    ntrk1-related familial medullary thyroid carcinoma    hereditary sensory and autonomic neuropathy iv
    hereditary sensory and autonomic neuropathy type v    thyroid medullary carcinoma    askin's tumor    olfactory neuroblastoma
    autonomic neuropathy    chagas disease    relapsing fever    dysautonomia
    adrenal neuroblastoma    pyruvate kinase deficiency    granular cell tumor    thymic epithelial tumor
    thymic carcinoma    neuroaxonal dystrophy    ganglioneuroblastoma    differentiating neuroblastoma

    4 diseases from the University of Copenhagen DISEASES database for NTRK1:
    Anhidrosis     Peripheral neuropathy     Thyroid cancer     Neuroblastoma

    NTRK1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NTRK1 gene (see all 95)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    anhidrosis 85.6 50 12949319 (2), 16138253 (2), 11139246 (2), 11159935 (2) (see all 26)
    hsan iv 83.3 7 18077166 (2), 16373086 (1), 15695606 (1), 11139246 (1) (see all 5)
    thyroid papillary carcinoma 73 37 10646882 (3), 8626874 (2), 11114633 (2), 7590742 (2) (see all 27)
    sensory neuropathy hereditary 64.3 3 15319794 (1), 16373086 (1), 8895241 (1)
    ganglioneuroma 58.8 7 10217562 (3), 8481906 (1), 19519647 (1), 9099963 (1) (see all 5)
    stage neuroblastoma 58 2 1737399 (1), 8256848 (1)
    pheochromocytoma 57.2 14 10217562 (3), 9425001 (1), 7508936 (1), 11027214 (1) (see all 11)
    ganglioneuroblastoma 57 1 15386308 (1)
    medulloblastoma 53.7 26 9560008 (3), 10617652 (2), 16771171 (2), 18719857 (2) (see all 10)
    papillary thyroid cancer 52.5 2 19765726 (1), 15273715 (1)

    GeneTests: NTRK1
    GeneReviews: NTRK1
    Genetic Association Database (GAD): NTRK1
    Human Genome Epidemiology (HuGE) Navigator: NTRK1 (28 documents)

    Export disorders for NTRK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NTRK1 gene, integrated from 10 sources (see all 1000):
    (articles sorted by number of sources associating them with NTRK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. (PubMed id 2869410)1, 2, 3 Martin-Zanca D.... Barbacid M. (Nature 1986)
    2. Congenital insensitivity to pain with anhidrosis (CIPA): effect of TRKA (NTRK1) missense mutations on autophosphorylation of the receptor tyrosine kinase for nerve growth factor. (PubMed id 11159935)1, 2, 9 Mardy S.... Indo Y. (Hum. Mol. Genet. 2001)
    3. Congenital insensitivity to pain with anhidrosis: novel mutations in the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor. (PubMed id 10330344)1, 2, 9 Mardy S.... Indo Y. (Am. J. Hum. Genet. 1999)
    4. Structural and mechanistic insights into nerve growth factor interactions with the TrkA and p75 receptors. (PubMed id 17196528)1, 2, 9 Wehrman T.... Garcia K.C. (Neuron 2007)
    5. Methylation adjacent to negatively regulating AP-1 site reactivates TrkA gene expression during cancer progression. (PubMed id 15870692)1, 2, 9 Fujimoto M.... Kitazawa S. (Oncogene 2005)
    6. Mutation and polymorphism analysis of the TRKA (NTRK1) gene encoding a high-affinity receptor for nerve growth factor in congenital insensitivity to pain with anhidrosis (CIPA) families. (PubMed id 10982191)1, 2, 9 Miura Y.... Indo Y. (Hum. Genet. 2000)
    7. Mutation analysis reveals novel sequence variants in NTRK1 in sporadic human medullary thyroid carcinoma. (PubMed id 10443680)1, 2, 9 Gimm O.... Eng C. (J. Clin. Endocrinol. Metab. 1999)
    8. Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. (PubMed id 8696348)1, 2, 9 Indo Y.... Matsuda I. (Nat. Genet. 1996)
    9. The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. (PubMed id 11244088)1, 2, 9 Wooten M.W.... Moscat J. (J. Biol. Chem. 2001)
    10. Crystal structure of nerve growth factor in complex with the ligand- binding domain of the TrkA receptor. (PubMed id 10490030)1, 2, 9 Wiesmann C.... de Vos A.M. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4914 HGNC: 8031 AceView: NTRK1 Ensembl:ENSG00000198400 euGenes: HUgn4914
    ECgene: NTRK1 Kegg: 4914 H-InvDB: NTRK1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NTRK1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NTRK1 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=NTRK1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NTRK1 gene:
    Search GeneIP for patents involving NTRK1

    Licensable Technologies for NTRK1 gene:
    Weizmann Institute:Induction of Apoptosis in Neural Cancer Cells
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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