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Aliases for NTPCR Gene

Aliases for NTPCR Gene

  • Nucleoside-Triphosphatase, Cancer-Related 2 3 5
  • Nucleoside Triphosphate Phosphohydrolase 3 4
  • Human Cancer-Related NTPase 2 3
  • C1orf57 3 4
  • NTPase 3 4
  • Chromosome 1 Open Reading Frame 57 2
  • Nucleoside-Triphosphatase C1orf57 3
  • EC 4
  • HCR-NTPase 3

External Ids for NTPCR Gene

Previous HGNC Symbols for NTPCR Gene

  • C1orf57

Previous GeneCards Identifiers for NTPCR Gene

  • GC01P233087

Summaries for NTPCR Gene

GeneCards Summary for NTPCR Gene

NTPCR (Nucleoside-Triphosphatase, Cancer-Related) is a Protein Coding gene. Among its related pathways are Metabolism and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis. GO annotations related to this gene include poly(A) RNA binding and nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot for NTPCR Gene

  • Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTPCR Gene

Genomics for NTPCR Gene

Regulatory Elements for NTPCR Gene

Enhancers for NTPCR Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NTPCR on UCSC Golden Path with GeneCards custom track

Promoters for NTPCR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NTPCR on UCSC Golden Path with GeneCards custom track

Genomic Location for NTPCR Gene

232,950,536 bp from pter
232,983,882 bp from pter
33,347 bases
Plus strand

Genomic View for NTPCR Gene

Genes around NTPCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTPCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTPCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTPCR Gene

Proteins for NTPCR Gene

  • Protein details for NTPCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cancer-related nucleoside-triphosphatase
    Protein Accession:

    Protein attributes for NTPCR Gene

    190 amino acids
    Molecular mass:
    20713 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NTPCR Gene

neXtProt entry for NTPCR Gene

Proteomics data for NTPCR Gene at MOPED

Post-translational modifications for NTPCR Gene

  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

Other Protein References for NTPCR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NTPCR Gene

Domains & Families for NTPCR Gene

Protein Domains for NTPCR Gene

Suggested Antigen Peptide Sequences for NTPCR Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the THEP1 NTPase family.
  • Belongs to the THEP1 NTPase family.
genes like me logo Genes that share domains with NTPCR: view

No data available for Gene Families for NTPCR Gene

Function for NTPCR Gene

Molecular function for NTPCR Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5 uM for ATP {ECO:0000269 PubMed:17291528}; KM=46 uM for ADP {ECO:0000269 PubMed:17291528}; KM=4 uM for GTP {ECO:0000269 PubMed:17291528}; KM=6 uM for CTP {ECO:0000269 PubMed:17291528}; KM=7 uM for TTP {ECO:0000269 PubMed:17291528};
UniProtKB/Swiss-Prot CatalyticActivity:
NTP + H(2)O = NDP + phosphate.
UniProtKB/Swiss-Prot Function:
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.

Enzyme Numbers (IUBMB) for NTPCR Gene

Gene Ontology (GO) - Molecular Function for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0017111 nucleoside-triphosphatase activity IEA --
GO:0098519 nucleotide phosphatase activity, acting on free nucleotides IEA --
genes like me logo Genes that share ontologies with NTPCR: view

Phenotypes for NTPCR Gene

GenomeRNAi human phenotypes for NTPCR:
genes like me logo Genes that share phenotypes with NTPCR: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NTPCR Gene

Localization for NTPCR Gene

Subcellular locations from

Jensen Localization Image for NTPCR Gene COMPARTMENTS Subcellular localization image for NTPCR gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NTPCR Gene

Pathways & Interactions for NTPCR Gene

genes like me logo Genes that share pathways with NTPCR: view

Gene Ontology (GO) - Biological Process for NTPCR Gene


No data available for SIGNOR curated interactions for NTPCR Gene

Drugs & Compounds for NTPCR Gene

(3) Drugs for NTPCR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
thiamin diphosphate Experimental Pharma 0
Thiamin Phosphate Experimental Pharma 0

(4) Additional Compounds for NTPCR Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with NTPCR: view

Transcripts for NTPCR Gene

Unigene Clusters for NTPCR Gene

Nucleoside-triphosphatase, cancer-related:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTPCR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - -
SP7: - - - - - - -
SP9: -

Relevant External Links for NTPCR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NTPCR Gene

mRNA expression in normal human tissues for NTPCR Gene

Protein differential expression in normal tissues from HIPED for NTPCR Gene

This gene is overexpressed in Tlymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NTPCR Gene

SOURCE GeneReport for Unigene cluster for NTPCR Gene Hs.642715

genes like me logo Genes that share expression patterns with NTPCR: view

Protein tissue co-expression partners for NTPCR Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NTPCR Gene

Orthologs for NTPCR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NTPCR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NTPCR 35
  • 83.33 (n)
  • 87.37 (a)
  • 88 (a)
(Canis familiaris)
Mammalia NTPCR 35
  • 85 (n)
  • 86.11 (a)
  • 48 (a)
(Mus musculus)
Mammalia Ntpcr 35
  • 79.72 (n)
  • 82.01 (a)
Ntpcr 16
Ntpcr 36
  • 81 (a)
(Pan troglodytes)
Mammalia NTPCR 35
  • 100 (n)
  • 100 (a)
  • 74 (a)
(Rattus norvegicus)
Mammalia Ntpcr 35
  • 79.72 (n)
  • 79.37 (a)
(Monodelphis domestica)
Mammalia NTPCR 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia NTPCR 36
  • 50 (a)
(Gallus gallus)
Aves NTPCR 35
  • 71.75 (n)
  • 70 (a)
  • 70 (a)
(Anolis carolinensis)
Reptilia NTPCR 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ntpcr 35
  • 61.58 (n)
  • 62.15 (a)
(Danio rerio)
Actinopterygii ntpcr 35
  • 60.69 (n)
  • 64.67 (a)
ntpcr 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005921 35
  • 43.65 (n)
  • 39.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10581 35
  • 49.8 (n)
  • 48.24 (a)
CG10581 36
  • 42 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G66005 35
  • 48.08 (n)
  • 41.21 (a)
Species with no ortholog for NTPCR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTPCR Gene

Gene Tree for NTPCR (if available)
Gene Tree for NTPCR (if available)

Paralogs for NTPCR Gene

(1) SIMAP similar genes for NTPCR Gene using alignment to 2 proteins: Pseudogenes for NTPCR Gene

genes like me logo Genes that share paralogs with NTPCR: view

No data available for Paralogs for NTPCR Gene

Variants for NTPCR Gene

Sequence variations from dbSNP and Humsavar for NTPCR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12123482 - 232,969,931(+) CCCAG(A/G)GCAAA intron-variant, reference, missense
rs13381 -- 232,950,710(+) ACCAG(A/C/G/T)ATGGC utr-variant-5-prime
rs743198 -- 232,951,136(-) AGGAA(A/G)TACCT intron-variant
rs743199 -- 232,951,203(-) TCGCT(C/G)TCCTC intron-variant
rs1045158 -- 232,978,081(+) CAGGC(G/T)TTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTPCR Gene

Variant ID Type Subtype PubMed ID
esv2750829 CNV Gain 17911159
nsv873306 CNV Gain 21882294

Variation tolerance for NTPCR Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NTPCR Gene

Disorders for NTPCR Gene

Relevant External Links for NTPCR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NTPCR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NTPCR Gene

Publications for NTPCR Gene

  1. NMR structure and functional characterization of a human cancer- related nucleoside triphosphatase. (PMID: 17291528) Placzek W.J. … Wuethrich K. (J. Mol. Biol. 2007) 2 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3

Products for NTPCR Gene

Sources for NTPCR Gene