NTPCR Gene
protein-coding GIFtS: 47
GCID: GC01P233087
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nucleoside-triphosphatase, cancer-related(Previous name: chromosome 1 open reading frame 57 )
(Previous symbol: C1orf57)
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Aliases
for NTPCR gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Nucleoside-Triphosphatase, Cancer-Related1 2 | | Chromosome 1 Open Reading Frame 571 | | C1orf571 2 3 | | RP4-678E16.22 | | HCR-NTPase1 2 | | Cancer-Related Nucleoside-Triphosphatase2 | | Nucleoside Triphosphate Phosphohydrolase2 3 | | Human Cancer-Related NTPase2 | | NTPase2 3 | | Nucleoside-Triphosphatase C1orf572 | | MGC131861 | | EC 3.6.1.153 |
Export aliases for NTPCR gene to outside databases |
Summaries
for NTPCR gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NTPCR_HUMAN, Q9BSD7Function: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphateswith lower efficiency
|
Genomic Views
for NTPCR gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for NTPCR
Other transcription factors
Search SABiosciences Chromatin IP Primers for NTPCR
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTPCR |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.2 Ensembl cytogenetic band: 1q42.2 HGNC cytogenetic band: 1q42.2NTPCR Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P233087: view genomic region
(about GC identifiers)
Start:
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233,086,351 bp from pter |
End:
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233,114,548 bp from pter |
Size:
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28,198 bases |
Orientation:
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plus strand |
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Proteins
for NTPCR gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NTPCR_HUMAN, Q9BSD7 (See
protein sequence)Recommended Name: Cancer-related nucleoside-triphosphatase Size: 190 amino acids; 20713 Da
Subunit: Monomer
1 PDB 3D structure from  and Proteopedia  for NTPCR:2I3B (3D)
Explore the universe of human proteins at neXtProt for NTPCR: NX_Q9BSD7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BSD7
NTPCR Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115700.1
ENSEMBL proteins: ENSP00000355587 ENSP00000355586
Human Recombinant Protein Products:
NTPCR Antibody Products:
Assay Products for NTPCR: |
Protein
Domains /
Families
for NTPCR gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NTPCR for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BSD7ProtoNet protein and cluster: Q9BSD7 1 Blocks protein family: IPB004948 Protein of unknown function DUF265
UniProtKB/Swiss-Prot: NTPCR_HUMAN, Q9BSD7Similarity: Belongs to the THEP1 NTPase family |
Function
for NTPCR gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NTPCR_HUMAN, Q9BSD7Function: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphateswith lower efficiencyCatalytic activity: NTP + H(2)O = NDP + phosphateBiophysicochemical properties: Kinetic parameters: KM=5 uM for ATP; KM=46 uM for ADP; KM=4 uM for GTP; KM=6 uM for CTP;KM=7 uM for TTP;Enzyme Number (IUBMB): EC 3.6.1.151
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTPCR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTPCR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NTPCR (NM_032324) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NTPCR | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTPCR |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTPCR |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005524 | ATP binding |
IEA | -- | | GO:0016740 | transferase activity |
IEA | -- | | GO:0017111 | nucleoside-triphosphatase activity |
IEA | -- | | GO:0019204 | nucleotide phosphatase activity |
IEA | -- |
NTPCR for ontologies About GeneDecksing
|
Pathways & Interactions
for NTPCR gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Purine metabolism | | | 2 | Metabolism | | | 3 | Vitamin B1 (thiamin) metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Kegg Pathways (Kegg details for NTPCR):
NTPCR for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NTPCR
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/80 Interacting proteins for NTPCR (Q9BSD73 ENSP000003555874) via UniProtKB, MINT, STRING, and/or I2D (see all 80)About this table
|
Drugs & Compounds
for NTPCR gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NTPCR
Search CenterWatch for drugs/clinical trials and news about NTPCR
|
Transcripts
for NTPCR gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NTPCR gene: NM_032324.1 Unigene Cluster for NTPCR: Nucleoside-triphosphatase, cancer-related Hs.642715 [show with all ESTs]Unigene Representative Sequence: BX5375418 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000494689(uc009xft.1) ENST00000490807 ENST00000366628(uc001hvj.1)
ENST00000496662 ENST00000366627 ENST00000479125 ENST00000487953 ENST00000490098
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTPCR (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTPCR
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NTPCR (NM_032324) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NTPCR | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTPCR |
Additional cDNA sequence: AF416713.1 AK311229.1 AK316591.1 BC005102.1 BX537541.1 14 DOTS entries: DT.454481 DT.120874 DT.75171536 DT.86678871 DT.100784449 DT.100028817 DT.95169971 DT.100784443 DT.100784444 DT.121411557 DT.121613639 DT.92433812 DT.95169972 DT.442371 24/224 AceView cDNA sequences (see all 224): AA632104 Z45692 AI200074 CA428901 AA814024 AI084015 AI084094 BQ778472 AI161302 T32008 AI056152 AI085313 CA445498 AA482362 AI632878 CR620575 AA813248 BQ776384 AA829780 BC005102 CR610348 AW516745 AA927412 AA576915
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NTPCR (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f |
|---|
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| SP1: | | | | | | | | | - | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NTPCR
|
Expression
for NTPCR gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NTPCR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAATTAAAT
About this image
See NTPCR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NTPCR
SOURCE GeneReport for Unigene cluster: Hs.642715
SABiosciences Custom PCR Arrays for NTPCR
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTPCR
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NTPCR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTPCR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTPCR | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTPCR |
Orthologs
for NTPCR gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NTPCR gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for NTPCR (if available)
TreeFam Gene Tree for NTPCR (if available) |
Paralogs
for NTPCR gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NTPCR gene
1 SIMAP similar gene for NTPCR using alignment to 2 protein entries: NTPCR_HUMAN (see all proteins):C1orf57
NTPCR for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for NTPCR
PGOHUM00000235773
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Genomic Variants
for NTPCR gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NTPCR (233086351 - 233114548 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NTPCR: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NTPCR |
|
Disorders
/ Diseases
for NTPCR gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for NTPCR gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NTPCR gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with NTPCR) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- NMR structure and functional characterization of a human cancer- related nucleoside triphosphatase. (PubMed id 17291528)1, 2, 3 Placzek W.J.... Wuethrich K. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- On the cytotoxicity of HCR-NTPase in the neuroblastom a cell line SH-SY5Y. (PubMed id 19519914)1 Pasdziernik M....Kaufmann M. (2009)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
|
External Searches for NTPCR gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NTPCR gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NTPCR gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NTPCR gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NTPCR | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NTPCR gene:
Search GeneIP for patents involving NTPCR
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NTPCR gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NTPCR | | OriGene shRNA RFP for NTPCR | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTPCR | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTPCR | | | OriGene Protein Over-expression Lysate for NTPCR | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NTPCR | | OriGene 3'-UTR Clone for NTPCR | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTPCR | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTPCR | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NTPCR | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NTPCR | | OriGene Custom Protein Services for NTPCR | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NTPCR | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NTPCR | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTPCR | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTPCR | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTPCR | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTPCR |
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 |  |  |  | |
| | | | Search Tocris compounds for NTPCR |
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 | | | NTPCR Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTPCR |
|  |  |  | | | | ThermoFisher Antibodies for NTPCR |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTPCR |
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