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Aliases for NTPCR Gene

Aliases for NTPCR Gene

  • Nucleoside-Triphosphatase, Cancer-Related 2 3 5
  • Nucleoside Triphosphate Phosphohydrolase 3 4
  • Human Cancer-Related NTPase 2 3
  • C1orf57 3 4
  • Cancer-Related Nucleoside-Triphosphatase 3
  • Chromosome 1 Open Reading Frame 57 2
  • Nucleoside-Triphosphatase C1orf57 3
  • EC 3.6.1.15 4
  • HCR-NTPase 3
  • NTPase 4

External Ids for NTPCR Gene

Previous HGNC Symbols for NTPCR Gene

  • C1orf57

Previous GeneCards Identifiers for NTPCR Gene

  • GC01P233087

Summaries for NTPCR Gene

Entrez Gene Summary for NTPCR Gene

  • The protein encoded by this gene is a non-specific nucleoside triphosphatase that is slow-acting in vitro. This gene is overexpressed in many tumor tissues, and while it is not essential for the cell, overexpression is cytotoxic. However, the cytotoxicity is not related to its triphosphatase activity. [provided by RefSeq, Jul 2016]

GeneCards Summary for NTPCR Gene

NTPCR (Nucleoside-Triphosphatase, Cancer-Related) is a Protein Coding gene. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and Purine metabolism (KEGG). GO annotations related to this gene include poly(A) RNA binding and nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot for NTPCR Gene

  • Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTPCR Gene

Genomics for NTPCR Gene

Regulatory Elements for NTPCR Gene

Enhancers for NTPCR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F232949 0.5 ENCODE 48.5 +0.2 199 2.1 HDGF ATF1 PKNOX1 SIN3A ZNF2 ETS1 YY1 GLIS2 ELK1 FOS NTPCR MAP10 GC01M232948 GC01M232977
GH01F232943 1 Ensembl ENCODE 47.2 -6.6 -6564 0.3 ZFHX2 IKZF1 ASH2L EGR2 NTPCR LOC105373201
GH01F232977 0.8 Ensembl ENCODE 47 +27.9 27885 1.3 ZNF133 SIN3A FEZF1 ZNF2 ZNF766 GATA2 FOS ZNF263 MAFF ETV4 NTPCR RNU6-1211P GC01M232977 GC01M232948
GH01F232937 0.7 Ensembl 45.8 -12.5 -12469 0.7 TBP HDAC1 LEF1 ATF1 TAL1 MAX GATA2 TRIM24 NR2F6 SMARCE1 NTPCR RNU6-1211P LOC105373201
GH01F232924 0.2 ENCODE 45.8 -24.8 -24778 1.6 NTPCR LOC105373201
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NTPCR on UCSC Golden Path with GeneCards custom track

Promoters for NTPCR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083627 264 2001 HDGF PKNOX1 SIN3A ZNF2 ETS1 YY1 GLIS2 ELK1 FOS KLF13

Genomic Location for NTPCR Gene

Chromosome:
1
Start:
232,950,536 bp from pter
End:
232,983,882 bp from pter
Size:
33,347 bases
Orientation:
Plus strand

Genomic View for NTPCR Gene

Genes around NTPCR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTPCR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTPCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTPCR Gene

Proteins for NTPCR Gene

  • Protein details for NTPCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSD7-NTPCR_HUMAN
    Recommended name:
    Cancer-related nucleoside-triphosphatase
    Protein Accession:
    Q9BSD7

    Protein attributes for NTPCR Gene

    Size:
    190 amino acids
    Molecular mass:
    20713 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NTPCR Gene

neXtProt entry for NTPCR Gene

Post-translational modifications for NTPCR Gene

  • Ubiquitination at Lys 21
  • Modification sites at PhosphoSitePlus

Other Protein References for NTPCR Gene

No data available for DME Specific Peptides for NTPCR Gene

Domains & Families for NTPCR Gene

Protein Domains for NTPCR Gene

Suggested Antigen Peptide Sequences for NTPCR Gene

Graphical View of Domain Structure for InterPro Entry

Q9BSD7

UniProtKB/Swiss-Prot:

NTPCR_HUMAN :
  • Belongs to the THEP1 NTPase family.
Family:
  • Belongs to the THEP1 NTPase family.
genes like me logo Genes that share domains with NTPCR: view

No data available for Gene Families for NTPCR Gene

Function for NTPCR Gene

Molecular function for NTPCR Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=5 uM for ATP {ECO:0000269 PubMed:17291528}; KM=46 uM for ADP {ECO:0000269 PubMed:17291528}; KM=4 uM for GTP {ECO:0000269 PubMed:17291528}; KM=6 uM for CTP {ECO:0000269 PubMed:17291528}; KM=7 uM for TTP {ECO:0000269 PubMed:17291528};
UniProtKB/Swiss-Prot CatalyticActivity:
NTP + H(2)O = NDP + phosphate.
UniProtKB/Swiss-Prot Function:
Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.

Enzyme Numbers (IUBMB) for NTPCR Gene

Gene Ontology (GO) - Molecular Function for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
GO:0017111 nucleoside-triphosphatase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0098519 nucleotide phosphatase activity, acting on free nucleotides IEA --
genes like me logo Genes that share ontologies with NTPCR: view

Phenotypes for NTPCR Gene

genes like me logo Genes that share phenotypes with NTPCR: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NTPCR

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NTPCR Gene

Localization for NTPCR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTPCR Gene COMPARTMENTS Subcellular localization image for NTPCR gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NTPCR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NTPCR Gene

Pathways & Interactions for NTPCR Gene

genes like me logo Genes that share pathways with NTPCR: view

Gene Ontology (GO) - Biological Process for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NTPCR: view

No data available for SIGNOR curated interactions for NTPCR Gene

Drugs & Compounds for NTPCR Gene

(4) Drugs for NTPCR Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
thiamin diphosphate Experimental Pharma 0

(3) Additional Compounds for NTPCR Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
NTP
thiamine monophosphate
  • Aneurin-monophosphorsaeureester
  • Aneurine monophosphate
  • Monofosfotiamina
  • Monophosphoric ester of thiamine
  • Monophosphothiamine
495-23-8
genes like me logo Genes that share compounds with NTPCR: view

Transcripts for NTPCR Gene

Unigene Clusters for NTPCR Gene

Nucleoside-triphosphatase, cancer-related:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for NTPCR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTPCR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - -
SP7: - - - - - - -
SP8:
SP9: -

Relevant External Links for NTPCR Gene

GeneLoc Exon Structure for
NTPCR
ECgene alternative splicing isoforms for
NTPCR

Expression for NTPCR Gene

mRNA expression in normal human tissues for NTPCR Gene

Protein differential expression in normal tissues from HIPED for NTPCR Gene

This gene is overexpressed in Tlymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NTPCR Gene



Protein tissue co-expression partners for NTPCR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NTPCR Gene:

NTPCR

SOURCE GeneReport for Unigene cluster for NTPCR Gene:

Hs.642715
genes like me logo Genes that share expression patterns with NTPCR: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NTPCR Gene

Orthologs for NTPCR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NTPCR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTPCR 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia NTPCR 34 35
  • 85 (n)
cow
(Bos Taurus)
Mammalia NTPCR 34 35
  • 83.33 (n)
oppossum
(Monodelphis domestica)
Mammalia NTPCR 35
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntpcr 34 16 35
  • 79.72 (n)
rat
(Rattus norvegicus)
Mammalia Ntpcr 34
  • 79.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NTPCR 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves NTPCR 34 35
  • 71.75 (n)
lizard
(Anolis carolinensis)
Reptilia NTPCR 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntpcr 34
  • 61.58 (n)
zebrafish
(Danio rerio)
Actinopterygii ntpcr 34 35
  • 60.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10581 34 35
  • 49.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005921 34
  • 43.65 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G66005 34
  • 48.08 (n)
Species where no ortholog for NTPCR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTPCR Gene

ENSEMBL:
Gene Tree for NTPCR (if available)
TreeFam:
Gene Tree for NTPCR (if available)

Paralogs for NTPCR Gene

(1) SIMAP similar genes for NTPCR Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NTPCR Gene

genes like me logo Genes that share paralogs with NTPCR: view

No data available for Paralogs for NTPCR Gene

Variants for NTPCR Gene

Sequence variations from dbSNP and Humsavar for NTPCR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10429825 -- 232,961,185(+) TGTTG(A/G)GCATT intron-variant
rs1045158 -- 232,978,081(+) CAGGC(G/T)TTTCT intron-variant
rs10797597 -- 232,952,064(+) AAACC(A/T)GTCCT intron-variant, upstream-variant-2KB
rs111288060 -- 232,953,566(+) CGGCA(-/T)ATTTT intron-variant
rs111431354 -- 232,950,862(+) AAGTT(A/C)CCAAT intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NTPCR Gene

Variant ID Type Subtype PubMed ID
esv2750829 CNV gain 17911159
esv3578476 CNV loss 25503493

Variation tolerance for NTPCR Gene

Residual Variation Intolerance Score: 68.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTPCR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTPCR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTPCR Gene

Disorders for NTPCR Gene

Relevant External Links for NTPCR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NTPCR

No disorders were found for NTPCR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NTPCR Gene

Publications for NTPCR Gene

  1. NMR structure and functional characterization of a human cancer- related nucleoside triphosphatase. (PMID: 17291528) Placzek W.J. … Wuethrich K. (J. Mol. Biol. 2007) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for NTPCR Gene

Sources for NTPCR Gene

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