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Aliases for NTPCR Gene

Aliases for NTPCR Gene

  • Nucleoside-Triphosphatase, Cancer-Related 2 3
  • Nucleoside Triphosphate Phosphohydrolase 3 4
  • Human Cancer-Related NTPase 2 3
  • C1orf57 3 4
  • NTPase 3 4
  • Cancer-Related Nucleoside-Triphosphatase 3
  • Chromosome 1 Open Reading Frame 57 2
  • Nucleoside-Triphosphatase C1orf57 3
  • EC 3.6.1.15 4
  • HCR-NTPase 3

External Ids for NTPCR Gene

Previous Symbols for NTPCR Gene

  • C1orf57

Summaries for NTPCR Gene

GeneCards Summary for NTPCR Gene

NTPCR (Nucleoside-Triphosphatase, Cancer-Related) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (KEGG). GO annotations related to this gene include nucleoside-triphosphatase activity and transferase activity.

UniProtKB/Swiss-Prot for NTPCR Gene

  • Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTPCR Gene

Genomics for NTPCR Gene

Genomic Location for NTPCR Gene

Start:
232,950,531 bp from pter
End:
232,983,882 bp from pter
Size:
33,352 bases
Orientation:
Plus strand

Genomic View for NTPCR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTPCR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTPCR Gene

No data available for Regulatory Elements for NTPCR Gene

Proteins for NTPCR Gene

  • Protein details for NTPCR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSD7-NTPCR_HUMAN
    Recommended name:
    Cancer-related nucleoside-triphosphatase
    Protein Accession:
    Q9BSD7
    Secondary Accessions:

    Protein attributes for NTPCR Gene

    Size:
    190 amino acids
    Molecular mass:
    20713 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for NTPCR Gene

neXtProt entry for NTPCR Gene

Proteomics data for NTPCR Gene at MOPED

Post-translational modifications for NTPCR Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys21

Other Protein References for NTPCR Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NTPCR Gene

Domains for NTPCR Gene

Protein Domains for NTPCR Gene

UniProtKB/Swiss-Prot:

NTPCR_HUMAN
Family:
  • Belongs to the THEP1 NTPase family.:
    • Q9BSD7
genes like me logo Genes that share domains with NTPCR: view

No data available for Gene Families for NTPCR Gene

Function for NTPCR Gene

Molecular function for NTPCR Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=5 uM for ATP {ECO:0000269 PubMed:17291528}; KM=46 uM for ADP {ECO:0000269 PubMed:17291528}; KM=4 uM for GTP {ECO:0000269 PubMed:17291528}; KM=6 uM for CTP {ECO:0000269 PubMed:17291528}; KM=7 uM for TTP {ECO:0000269 PubMed:17291528};
UniProtKB/Swiss-Prot CatalyticActivity: NTP + H(2)O = NDP + phosphate
UniProtKB/Swiss-Prot Function: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency.

Enzyme Numbers (IUBMB) for NTPCR Gene

Gene Ontology (GO) - Molecular Function for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016887 ATPase activity --
GO:0017111 nucleoside-triphosphatase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
GO:0098519 nucleotide phosphatase activity, acting on free nucleotides IEA --
genes like me logo Genes that share ontologies with NTPCR: view

miRNA for NTPCR Gene

miRTarBase miRNAs that target NTPCR

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NTPCR Gene

Localization for NTPCR Gene

Gene Ontology (GO) - Cellular Components for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with NTPCR: view

Pathways for NTPCR Gene

genes like me logo Genes that share pathways with NTPCR: view

Gene Ontology (GO) - Biological Process for NTPCR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NTPCR: view

Transcripts for NTPCR Gene

Unigene Clusters for NTPCR Gene

Nucleoside-triphosphatase, cancer-related:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTPCR Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - - -
SP5: - -
SP6: - -
SP7: - - - - - - -
SP8:
SP9: -

Relevant External Links for NTPCR Gene

GeneLoc Exon Structure for
NTPCR
ECgene alternative splicing isoforms for
NTPCR

Expression for NTPCR Gene

mRNA expression in normal human tissues for NTPCR Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NTPCR Gene

SOURCE GeneReport for Unigene cluster for NTPCR Gene Hs.642715

genes like me logo Genes that share expressions with NTPCR: view

Orthologs for NTPCR Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NTPCR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTPCR 36
  • 100 (n)
  • 100 (a)
NTPCR 37
  • 74 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NTPCR 36
  • 83.33 (n)
  • 87.37 (a)
NTPCR 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTPCR 36
  • 85 (n)
  • 86.11 (a)
NTPCR 37
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntpcr 36
  • 79.72 (n)
  • 82.01 (a)
Ntpcr 16
Ntpcr 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTPCR 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTPCR 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntpcr 36
  • 79.72 (n)
  • 79.37 (a)
chicken
(Gallus gallus)
Aves NTPCR 36
  • 71.75 (n)
  • 70 (a)
NTPCR 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTPCR 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntpcr 36
  • 61.58 (n)
  • 62.15 (a)
zebrafish
(Danio rerio)
Actinopterygii ntpcr 36
  • 60.69 (n)
  • 64.67 (a)
ntpcr 37
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005921 36
  • 43.65 (n)
  • 39.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10581 36
  • 49.8 (n)
  • 48.24 (a)
CG10581 37
  • 42 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G66005 36
  • 48.08 (n)
  • 41.21 (a)
Species with no ortholog for NTPCR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTPCR Gene

ENSEMBL:
Gene Tree for NTPCR (if available)
TreeFam:
Gene Tree for NTPCR (if available)

Paralogs for NTPCR Gene

Selected SIMAP similar genes for NTPCR Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for NTPCR Gene

genes like me logo Genes that share paralogs with NTPCR: view

No data available for Paralogs for NTPCR Gene

Variants for NTPCR Gene

Sequence variations from dbSNP and Humsavar for NTPCR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13381 -- 232,950,710(+) ACCAG(A/C/G/T)ATGGC utr-variant-5-prime
rs743198 -- 232,951,136(-) AGGAA(A/G)TACCT intron-variant
rs743199 -- 232,951,203(-) TCGCT(C/G)TCCTC intron-variant
rs1045158 -- 232,978,081(+) CAGGC(G/T)TTTCT intron-variant
rs1885004 -- 232,976,205(+) TGCAT(A/G)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTPCR Gene

Variant ID Type Subtype PubMed ID
esv2750829 CNV Gain 17911159
nsv873306 CNV Gain 21882294

Relevant External Links for NTPCR Gene

HapMap Linkage Disequilibrium report
NTPCR

Disorders for NTPCR Gene

No disorders were found for NTPCR Gene.

No data available for UniProtKB/Swiss-Prot for NTPCR Gene

Publications for NTPCR Gene

  1. NMR structure and functional characterization of a human cancer- related nucleoside triphosphatase. (PMID: 17291528) Placzek W.J. … Wuethrich K. (J. Mol. Biol. 2007) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3
  5. On the cytotoxicity of HCR-NTPase in the neuroblastoma cell line SH-SY5Y. (PMID: 19519914) Pasdziernik M. … Kaufmann M. (BMC Res Notes 2009) 3

Products for NTPCR Gene

  • Addgene plasmids for NTPCR

Sources for NTPCR Gene

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