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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTPCR Gene

protein-coding   GIFtS: 49
GCID: GC01P233087

Nucleoside-Triphosphatase, Cancer-Related

(Previous name: chromosome 1 open reading frame 57)
(Previous symbol: C1orf57)
  Search for NTPCR
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Nucleoside-Triphosphatase, Cancer-Related1 2     HCR-NTPase2
C1orf571 2 3     RP4-678E16.22
Human Cancer-Related NTPase1 2     Cancer-Related Nucleoside-Triphosphatase2
Nucleoside Triphosphate Phosphohydrolase2 3     Nucleoside-Triphosphatase C1orf572
NTPase2 3     EC 3.6.1.153
Chromosome 1 Open Reading Frame 571     

External Ids:    HGNC: 282041   Entrez Gene: 842842   Ensembl: ENSG000001357787   UniProtKB: Q9BSD73   

Export aliases for NTPCR gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NTPCR Gene: 
NTPCR (nucleoside-triphosphatase, cancer-related) is a protein-coding gene. Among its related super-pathways are pyrimidine deoxyribonucleotides biosynthesis from CTP and UTP and CTP dephosphorylation II. GO annotations related to this gene include nucleoside-triphosphatase activity and nucleotide phosphatase activity.

UniProtKB/Swiss-Prot: NTPCR_HUMAN, Q9BSD7
Function: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside
diphosphates with lower efficiency




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_167186.1  NC_018912.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NTPCR
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NTPCR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTPCR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.2   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.2

NTPCR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTPCR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P233087:  view genomic region     (about GC identifiers)

Start:
233,086,351 bp from pter      End:
233,114,548 bp from pter
Size:
28,198 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NTPCR_HUMAN, Q9BSD7 (See protein sequence)
Recommended Name: Cancer-related nucleoside-triphosphatase  
Size: 190 amino acids; 20713 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for NTPCR:
2I3B (3D)    

Explore the universe of human proteins at neXtProt for NTPCR: NX_Q9BSD7

Explore proteomics data for NTPCR at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BSD7

  • NTPCR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NTPCR Protein Expression
    REFSEQ proteins: NP_115700.1  
    ENSEMBL proteins: 
     ENSP00000355587   ENSP00000355586  

    Human Recombinant Protein Products for NTPCR: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NTPCR
    OriGene Protein Over-expression Lysate for NTPCR
    OriGene MassSpec for NTPCR 
    OriGene Custom Protein Services for NTPCR
    GenScript Custom Purified and Recombinant Proteins Services for NTPCR
    Novus Biologicals NTPCR Proteins
    Novus Biologicals NTPCR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NTPCR 


    NTPCR Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals NTPCR Antibodies
    Abcam antibodies for NTPCR
    Cloud-Clone Corp. Antibodies for NTPCR 
    ThermoFisher Antibodies for NTPCR
    LSBio Antibodies in human, mouse, rat for NTPCR 

    Assay Products for NTPCR: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NTPCR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NTPCR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NTPCR 
    Cloud-Clone Corp. CLIAs for NTPCR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR004948 Nuc-triphosphatase_THEP1
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q9BSD7

    ProtoNet protein and cluster: Q9BSD7

    1 Blocks protein domain: IPB004948 Protein of unknown function DUF265

    UniProtKB/Swiss-Prot: NTPCR_HUMAN, Q9BSD7
    Similarity: Belongs to the THEP1 NTPase family


    NTPCR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTPCR_HUMAN, Q9BSD7
    Function: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside
    diphosphates with lower efficiency
    Catalytic activity: NTP + H(2)O = NDP + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=5 uM for ATP; KM=46 uM for ADP; KM=4 uM for GTP; KM=6 uM for
    CTP; KM=7 uM for TTP;

         Enzyme Number (IUBMB): EC 3.6.1.151

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:0016740transferase activity IEA--
    GO:0016887ATPase activity ----
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    NTPCR for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NTPCR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NTPCR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTPCR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTPCR 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTPCR
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NTPCR:
    hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidNTPCR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NTPCR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTPCR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NTPCR
    Sirion Biotech Customized adenovirus for overexpression of NTPCR

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for NTPCR (see all 7)
    OriGene ORF clones in mouse, rat for NTPCR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NTPCR (NM_032324)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTPCR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTPCR
    Sirion Biotech Customized lentivirus for stable overexpression of NTPCR 
                         Customized lentivirus expression plasmids for stable overexpression of NTPCR 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for NTPCR
    Search LifeMap BioReagents cell lines for NTPCR
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTPCR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NTPCR About                                                                                                See pathways by source

    SuperPathContained pathways About
    1superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
    pyrimidine deoxyribonucleotides de novo biosynthesis I0.88
    pyrimidine deoxyribonucleotides biosynthesis from CTP0.88
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)0.88
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.71
    2UTP and CTP dephosphorylation II
    UTP and CTP dephosphorylation I0.40
    3Metabolism
    Metabolic pathways0.40
    4Purine metabolism
    Purine metabolism0.38
    5Vitamin B1 (thiamin) metabolism
    Thiamine metabolism0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for NTPCR
        superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli)
    UTP and CTP dephosphorylation I
    pyrimidine deoxyribonucleotides de novo biosynthesis I
    pyrimidine deoxyribonucleotides biosynthesis from CTP


    3         Kegg Pathways  (Kegg details for NTPCR):
        Purine metabolism
    Thiamine metabolism
    Metabolic pathways


    NTPCR for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NTPCR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/80 Interacting proteins for NTPCR (Q9BSD73 ENSP000003555874) via UniProtKB, MINT, STRING, and/or I2D (see all 80)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    RUVBL1Q9Y2653, ENSP000003182974I2D: score=1 STRING: ENSP00000318297
    ATG10Q9H0Y03I2D: score=1 
    ATG2AQ2TAZ03I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NTPCR

    Search CenterWatch for drugs/clinical trials and news about NTPCR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NTPCR gene: 
    NM_032324.1  

    Unigene Cluster for NTPCR:

    Nucleoside-triphosphatase, cancer-related
    Hs.642715  [show with all ESTs]
    Unigene Representative Sequence: BX537541
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494689(uc009xft.1) ENST00000490807 ENST00000366628(uc001hvj.1)
    ENST00000496662 ENST00000366627 ENST00000479125 ENST00000487953 ENST00000490098

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTPCR
    1 QIAGEN miScript miRNA Assays for microRNA that regulate NTPCR:
    hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidNTPCR 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NTPCR
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTPCR
    Clone
    Products:
         
    OriGene clones in human, mouse for NTPCR (see all 7)
    OriGene ORF clones in mouse, rat for NTPCR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NTPCR (NM_032324)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTPCR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTPCR
    Sirion Biotech Customized lentivirus for stable overexpression of NTPCR 
                         Customized lentivirus expression plasmids for stable overexpression of NTPCR 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NTPCR
    OriGene qSTAR qPCR primer pairs in human, mouse for NTPCR
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NTPCR
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTPCR
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTPCR

    Additional mRNA sequence: 

    AF416713.1 AK311229.1 AK316591.1 BC005102.1 BX537541.1 

    14 DOTS entries:

    DT.454481  DT.120874  DT.75171536  DT.86678871  DT.100784449  DT.100028817  DT.95169971  DT.100784443 
    DT.100784444  DT.121411557  DT.121613639  DT.92433812  DT.95169972  DT.442371 

    24/224 AceView cDNA sequences (see all 224):

    BQ447356 Z41359 BQ776384 R10337 BU169653 AA485043 BX509963 AI339805 
    AI333484 AA927412 N62846 BC005102 AA576915 AW516745 CR612278 AA829780 
    BM990438 AA632073 AA813248 BQ001389 AA482362 BG681831 W80670 BQ286550 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NTPCR (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:                          -                       -     -           -                                       
    SP2:                          -     -     -           -     -           -                                       
    SP3:                          -                       -     -     -     -                                       
    SP4:                          -     -     -           -     -           -                                       
    SP5:                                                  -     -                                                   


    ECgene alternative splicing isoforms for NTPCR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTPCR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATTAAAT
    NTPCR Expression
    About this image


    See NTPCR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTPCR

    SOURCE GeneReport for Unigene cluster: Hs.642715
        SABiosciences Custom PCR Arrays for NTPCR
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTPCR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTPCR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NTPCR gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntpcr1 , 5 nucleoside-triphosphatase, cancer-related1, 5 79.72(n)1
    82.01(a)1
      8 (73.65 cM)5
    665661  NM_025636.51  NP_079912.11 
     1257299635 
    chicken
    (Gallus gallus)
    Aves NTPCR1 nucleoside-triphosphatase, cancer-related 71.75(n)
    70(a)
      428588  NM_001031523.1  NP_001026694.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTPCR6
    Uncharacterized protein
    59(a)
    1 ↔ 1
    1(220845891-220864879)
    zebrafish
    (Danio rerio)
    Actinopterygii ntpcr1 nucleoside-triphosphatase, cancer-related 60.87(n)
    64.67(a)
      445069  NM_001003463.1  NP_001003463.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105811 CG10581 50(n)
    48.24(a)
      40326  NM_141022.4  NP_649279.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G660051 hypothetical protein 48.08(n)
    41.21(a)
      2746218  NM_001037080.2  NP_001032157.1 


    ENSEMBL Gene Tree for NTPCR (if available)
    TreeFam Gene Tree for NTPCR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTPCR gene
    1 SIMAP similar gene for NTPCR using alignment to 2 protein entries:     NTPCR_HUMAN (see all proteins):
    C1orf57

    NTPCR for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NTPCR
    PGOHUM00000235773


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/559 SNPs in NTPCR are shown (see all 559)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127300711,2
    C,F--233084465(+) ATACAG/AGAAAC 1 -- us2k12Minor allele frequency- A:0.03CSA WA 120
    rs1177545011,2
    F--233084469(+) AGGAAA/TCTGTA 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1842551911,2
    C--233084540(+) AAATAA/GTTCAT 1 -- us2k10--------
    rs1878385861,2
    --233084651(+) ACTGAC/TGCCAG 1 -- us2k10--------
    rs38201241,2
    C,F,A,H--233084744(-) ATCAGA/GTAGCA 1 -- us2k127Minor allele frequency- G:0.27NS EA NA CSA WA 2908
    rs37953781,2
    C,F,A,H--233084852(-) ATACAG/ATGAAA 1 -- us2k124Minor allele frequency- A:0.27NA EA NS CSA WA 2561
    rs1404876111,2
    C--233084914(+) AGTTGC/GGATAA 1 -- us2k10--------
    rs1504219961,2
    --233085011(+) GTTTTC/TTTAGA 1 -- us2k10--------
    rs1923523001,2
    --233085104(+) TCACTG/TAACTG 1 -- us2k10--------
    rs788609291,2
    F--233085221(+) CGTTGA/GCCGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NTPCR (233086351 - 233114548 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NTPCR:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv873306CNV Gain21882294
    esv2750829CNV Gain17911159

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing NTPCR
    DNA2.0 Custom Variant and Variant Library Synthesis for NTPCR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTPCR gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with NTPCR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NMR structure and functional characterization of a human cancer- related nucleoside triphosphatase. (PubMed id 17291528)1, 2, 3 Placzek W.J.... Wuethrich K. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    4. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (2013)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84284 HGNC: 28204 AceView: MGC13186 Ensembl:ENSG00000135778 euGenes: HUgn84284
    ECgene: NTPCR Kegg: 84284 H-InvDB: NTPCR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTPCR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NTPCR gene:
    Search GeneIP for patents involving NTPCR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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