Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NTPCR Gene

protein-coding   GIFtS: 51
GCID: GC01P233087

Nucleoside-Triphosphatase, Cancer-Related

(Previous name: chromosome 1 open reading frame 57)
(Previous symbol: C1orf57)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Nucleoside-Triphosphatase, Cancer-Related1 2     Chromosome 1 Open Reading Frame 571
C1orf571 2 3     HCR-NTPase2
Human Cancer-Related NTPase1 2     Cancer-Related Nucleoside-Triphosphatase2
Nucleoside Triphosphate Phosphohydrolase2 3     Nucleoside-Triphosphatase C1orf572
NTPase2 3     EC 3.6.1.153

External Ids:    HGNC: 282041   Entrez Gene: 842842   Ensembl: ENSG000001357787   UniProtKB: Q9BSD73   
ORGUL members:         

Export aliases for NTPCR gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for NTPCR Gene:
NTPCR (nucleoside-triphosphatase, cancer-related) is a protein-coding gene. Diseases associated with NTPCR include neuroblastoma, and malaria. GO annotations related to this gene include nucleoside-triphosphatase activity and transferase activity.

UniProtKB/Swiss-Prot: NTPCR_HUMAN, Q9BSD7
Function: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside
diphosphates with lower efficiency




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_167186.2  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for NTPCR
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NTPCR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTPCR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.2   Ensembl cytogenetic band:  1q42.2   HGNC cytogenetic band: 1q42.2

NTPCR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTPCR gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P233087:  view genomic region     (about GC identifiers)

Start:
233,086,351 bp from pter      End:
233,119,628 bp from pter
Size:
33,278 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NTPCR_HUMAN, Q9BSD7 (See protein sequence)
Recommended Name: Cancer-related nucleoside-triphosphatase  
Size: 190 amino acids; 20713 Da
Subunit: Monomer
1 PDB 3D structure from and Proteopedia for NTPCR:
2I3B (3D)    

Explore the universe of human proteins at neXtProt for NTPCR: NX_Q9BSD7

Explore proteomics data for NTPCR at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21
  • Modification sites at PhosphoSitePlus

  • See NTPCR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115700.1  
    ENSEMBL proteins: 
     ENSP00000355587   ENSP00000355586  

    NTPCR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NTPCR
    OriGene Protein Over-expression Lysate for NTPCR
    OriGene MassSpec for NTPCR
    OriGene Custom Protein Services for NTPCR
    GenScript Custom Purified and Recombinant Proteins Services for NTPCR
    Novus Biologicals NTPCR Proteins
    Novus Biologicals NTPCR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NTPCR

    NTPCR Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for NTPCR
    OriGene Custom Antibody Services for NTPCR
    Novus Biologicals NTPCR Antibodies
    Abcam antibodies for NTPCR
    Cloud-Clone Corp. Antibodies for NTPCR
    ThermoFisher Antibodies for NTPCR
    LSBio Antibodies in human, mouse, rat for NTPCR

    NTPCR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NTPCR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NTPCR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NTPCR
    Cloud-Clone Corp. CLIAs for NTPCR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR004948 Nuc-triphosphatase_THEP1
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q9BSD7

    ProtoNet protein and cluster: Q9BSD7

    1 Blocks protein domain: IPB004948 Protein of unknown function DUF265

    UniProtKB/Swiss-Prot: NTPCR_HUMAN, Q9BSD7
    Similarity: Belongs to the THEP1 NTPase family


    NTPCR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTPCR_HUMAN, Q9BSD7
    Function: Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside
    diphosphates with lower efficiency
    Catalytic activity: NTP + H(2)O = NDP + phosphate
    Biophysicochemical properties: Kinetic parameters: KM=5 uM for ATP; KM=46 uM for ADP; KM=4 uM for GTP; KM=6 uM for
    CTP; KM=7 uM for TTP;

         Enzyme Number (IUBMB): EC 3.6.1.151

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005524ATP binding IEA--
    GO:0016887ATPase activity ----
    GO:0017111nucleoside-triphosphatase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    NTPCR for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NTPCR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NTPCR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTPCR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTPCR

    miRNA
    Products:
        
    miRTarBase miRNAs that target NTPCR:
    hsa-mir-92a-3p (MIRT049086)

    Block miRNA regulation of human, mouse, rat NTPCR using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NTPCR:
    hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidNTPCR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NTPCR
    Predesigned siRNA for gene silencing in human, mouse, rat NTPCR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NTPCR

    Clone
    Products:
         
    OriGene clones in human, mouse for NTPCR (see all 6)
    OriGene ORF clones in mouse, rat for NTPCR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NTPCR (NM_032324)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTPCR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTPCR

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NTPCR
    Browse ESI BIO Cell Lines and PureStem Progenitors for NTPCR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTPCR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus
      --

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NTPCR About    
    See pathways by source

    SuperPathContained pathways About
    1superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis0.52
    pyrimidine deoxyribonucleotides de novo biosynthesis0.00
    UTP and CTP dephosphorylation I0.00
    pyrimidine deoxyribonucleotides biosynthesis from CTP0.00
    2Purine metabolism (KEGG)
    Purine metabolism0.38
    3Metabolism
    Metabolic pathways0.38
    4Thiamine metabolism
    Thiamine metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for NTPCR
        superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    pyrimidine deoxyribonucleotides biosynthesis from CTP
    pyrimidine deoxyribonucleotides de novo biosynthesis
    UTP and CTP dephosphorylation I


    3 Kegg Pathways  (Kegg details for NTPCR):
        Purine metabolism
    Thiamine metabolism
    Metabolic pathways


    NTPCR for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NTPCR
    Interactions:

        Search GeneGlobe Interaction Network for NTPCR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NTPCR (Q9BSD73 ENSP000003555874) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    RUVBL2Q9Y2303, ENSP000002214134I2D: score=1 STRING: ENSP00000221413
    RUVBL1Q9Y2653, ENSP000003182974I2D: score=1 STRING: ENSP00000318297
    ATG10Q9H0Y03I2D: score=1 
    ATG2AQ2TAZ03I2D: score=1 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NTPCR



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NTPCR gene: 
    NM_032324.1  

    Unigene Cluster for NTPCR:

    Nucleoside-triphosphatase, cancer-related
    Hs.642715  [show with all ESTs]
    Unigene Representative Sequence: BX537541
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494689(uc009xft.1) ENST00000490807 ENST00000366628(uc001hvj.1)
    ENST00000496662 ENST00000366627 ENST00000479125 ENST00000487953 ENST00000490098

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NTPCR using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate NTPCR:
    hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidNTPCR 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NTPCR
    Predesigned siRNA for gene silencing in human, mouse, rat NTPCR
    Clone
    Products:
         
    OriGene clones in human, mouse for NTPCR (see all 6)
    OriGene ORF clones in mouse, rat for NTPCR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NTPCR (NM_032324)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTPCR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTPCR
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NTPCR
    OriGene qSTAR qPCR primer pairs in human, mouse for NTPCR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NTPCR
      QuantiTect SYBR Green Assays in human, mouse, rat NTPCR
      QuantiFast Probe-based Assays in human, mouse, rat NTPCR

    Additional mRNA sequence: 

    AF416713.1 AK311229.1 AK316591.1 BC005102.1 BX537541.1 

    14 DOTS entries:

    DT.454481  DT.120874  DT.75171536  DT.86678871  DT.100784449  DT.100028817  DT.95169971  DT.100784443 
    DT.100784444  DT.121411557  DT.121613639  DT.92433812  DT.95169972  DT.442371 

    Selected AceView cDNA sequences (see all 224):

    AI339805 AA719788 R10337 AI200074 BF593985 BU169653 AI161302 CA432100 
    AA826596 AA902514 CR610348 AA829780 AI242276 AA576915 BX509963 BQ778472 
    AI632878 BM809394 AI222458 W80670 AA434399 BQ447356 AA485043 BU076244 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NTPCR (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
    SP1:                          -                       -     -           -                                       
    SP2:                          -     -     -           -     -           -                                       
    SP3:                          -                       -     -     -     -                                       
    SP4:                          -     -     -           -     -           -                                       
    SP5:                                                  -     -                                                   


    ECgene alternative splicing isoforms for NTPCR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NTPCR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATTAAAT
    NTPCR Expression
    About this image

    NTPCR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NTPCR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.642715
        Custom PCR Arrays for NTPCR
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NTPCR
    OriGene qSTAR qPCR primer pairs in human, mouse for NTPCR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NTPCR
    QuantiTect SYBR Green Assays in human, mouse, rat NTPCR
    QuantiFast Probe-based Assays in human, mouse, rat NTPCR
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTPCR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NTPCR gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntpcr1 , 5 nucleoside-triphosphatase, cancer-related1, 5 79.72(n)1
    82.01(a)1
      8 (73.65 cM)5
    665661  NM_025636.51  NP_079912.11 
     1257299635 
    chicken
    (Gallus gallus)
    Aves NTPCR1 nucleoside-triphosphatase, cancer-related 71.75(n)
    70(a)
      428588  NM_001031523.1  NP_001026694.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTPCR6
    nucleoside-triphosphatase, cancer-related
    59(a)
    1 ↔ 1
    1(220845891-220864879)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ntpcr1 nucleoside-triphosphatase, cancer-related 61.58(n)
    62.15(a)
      100492066  XM_002935821.2  XP_002935867.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ntpcr1 nucleoside-triphosphatase, cancer-related 60.69(n)
    64.67(a)
      445069  NM_001003463.1  NP_001003463.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105811 CG10581 49.8(n)
    48.24(a)
      40326  NM_141022.4  NP_649279.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G660051 AT5G66005 48.08(n)
    41.21(a)
      2746218  NM_001037080.2  NP_001032157.1 


    ENSEMBL Gene Tree for NTPCR (if available)
    TreeFam Gene Tree for NTPCR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NTPCR gene
    1 SIMAP similar gene for NTPCR using alignment to 2 protein entries:     NTPCR_HUMAN (see all proteins):
    C1orf57

    NTPCR for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NTPCR
    PGOHUM00000235773


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NTPCR (see all 559)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127300711,2
    C,F--233084465(+) ATACAG/AGAAAC 1 -- us2k12Minor allele frequency- A:0.03CSA WA 120
    rs1177545011,2
    F--233084469(+) AGGAAA/TCTGTA 1 -- us2k11Minor allele frequency- T:0.02EA 120
    rs1842551911,2
    C--233084540(+) AAATAA/GTTCAT 1 -- us2k10--------
    rs1878385861,2
    --233084651(+) ACTGAC/TGCCAG 1 -- us2k10--------
    rs38201241,2
    C,F,A,H--233084744(-) ATCAGA/GTAGCA 1 -- us2k127Minor allele frequency- G:0.27NS EA NA CSA WA 2908
    rs37953781,2
    C,F,A,H--233084852(-) ATACAG/ATGAAA 1 -- us2k124Minor allele frequency- A:0.27NA EA NS CSA WA 2561
    rs1404876111,2
    C--233084914(+) AGTTGC/GGATAA 1 -- us2k10--------
    rs1504219961,2
    --233085011(+) GTTTTC/TTTAGA 1 -- us2k10--------
    rs1923523001,2
    --233085104(+) TCACTG/TAACTG 1 -- us2k10--------
    rs788609291,2
    F--233085221(+) CGTTGA/GCCGGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NTPCR (233086351 - 233119628 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NTPCR:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873306CNV Gain21882294
    esv2750829CNV Gain17911159

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NTPCR
    DNA2.0 Custom Variant and Variant Library Synthesis for NTPCR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    2 diseases for NTPCR:    
    About MalaCards
    neuroblastoma    malaria


    NTPCR for disorders           About GeneDecksing


    Export disorders for NTPCR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NTPCR gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with NTPCR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NMR structure and functional characterization of a human cancer- related nucleoside triphosphatase. (PubMed id 17291528)1, 2, 3 Placzek W.J.... Wuethrich K. (J. Mol. Biol. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    4. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    5. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    6. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    7. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 84284 HGNC: 28204 AceView: MGC13186 Ensembl:ENSG00000135778 euGenes: HUgn84284
    ECgene: NTPCR Kegg: 84284 H-InvDB: NTPCR

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NTPCR Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NTPCR gene:
    Search GeneIP for patents involving NTPCR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NTPCR   OriGene RNAi products in human, mouse, rat for NTPCR  
     OriGene qPCR primer pairs and template standards for NTPCR   OriGene Protein Over-expression Lysate for NTPCR  
     OriGene MassSpec something-or-other for NTPCR   OriGene clones in human, mouse for NTPCR  
     OriGene qSTAR qPCR primer pairs in human, mouse for NTPCR   OriGene Purified Protein for NTPCR  
     OriGene ORF clones in mouse, rat for NTPCR   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NTPCR   OriGene Custom Protein Services for NTPCR  

     
     
     Block miRNA regulation of human, mouse, rat NTPCR using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NTPCR
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTPCR Predesigned siRNA for gene silencing in human, mouse, rat NTPCR
     QuantiFast Probe-based Assays in human, mouse, rat NTPCR QuantiTect SYBR Green Assays in human, mouse, rat NTPCR
     Custom PCR Arrays for NTPCR Search Chromatin IP Primers for NTPCR
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NTPCR  Search GeneGlobe Interaction Network for NTPCR
     Search Regulatory tfbs for NTPCR
     GenScript Custom Purified and Recombinant Proteins Services for NTPCR GenScript cDNA clones with any tag delivered in your preferred vector for NTPCR
     GenScript Custom Assay Services for NTPCR GenScript Custom overexpressing Cell Line Services for NTPCR
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NTPCR
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NTPCR antibodies
     NTPCR proteins
     NTPCR lysates
     Antibodies for NTPCR
     See all of Abcam's Antibodies, Kits and Proteins for NTPCR
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NTPCR
     Antibodies for NTPCR
     ELISAs for NTPCR
     CLIAs for NTPCR



     Browse ESI BIO Cell Lines and PureStem Progenitors for NTPCR
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTPCR
     SwitchGear 3'UTR luciferase reporter plasmids for NTPCR
     Browse SwitchGear Promoter luciferase reporter plasmids for NTPCR
     ThermoFisher Antibodies for NTPCR
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTPCR
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NTPCR
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NTPCR
     LSBio Antibodies in human, mouse, rat for NTPCR
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NTPCR gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4