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Aliases for NTNG2 Gene

Aliases for NTNG2 Gene

  • Netrin G2 2 3 5
  • Netrin G1 2 3
  • Netrin-G2 2 3
  • Lmnt2 3 4
  • BA479K20.1 (Novel Protein) 3
  • BA479K20.1 3
  • Laminet 2 3
  • Laminet-2 4
  • LHLL9381 3
  • KIAA1857 4
  • NTNG1 3

External Ids for NTNG2 Gene

Previous HGNC Symbols for NTNG2 Gene

  • NTNG1

Previous GeneCards Identifiers for NTNG2 Gene

  • GC09P130318
  • GC09P132066
  • GC09P134026
  • GC09P135037
  • GC09P104523

Summaries for NTNG2 Gene

GeneCards Summary for NTNG2 Gene

NTNG2 (Netrin G2) is a Protein Coding gene. Diseases associated with NTNG2 include Rett Syndrome. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is NTNG1.

UniProtKB/Swiss-Prot for NTNG2 Gene

  • Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Gene Wiki entry for NTNG2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTNG2 Gene

Genomics for NTNG2 Gene

Regulatory Elements for NTNG2 Gene

Enhancers for NTNG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F132005 1 FANTOM5 Ensembl ENCODE 12 -153.8 -153800 4.1 TBP PKNOX1 TBL1XR1 ZNF133 FEZF1 RFX5 RCOR1 ETV6 FOS CREM NTNG2 MED27 SETX PIR57956
GH09F132126 0.6 Ensembl 11.7 -35.2 -35152 0.2 NTNG2 LOC105376302
GH09F132125 0.5 ENCODE 11.7 -36.1 -36124 0.2 CBX3 ZNF280D ZNF518A ZNF610 ZNF26 ZSCAN29 MAFK TRIM28 ZNF558 NTNG2 ENSG00000246851 LOC105376302
GH09F131774 0.7 ENCODE 11.1 -387.4 -387424 0.2 MXI1 ZNF146 USF1 ZNF792 KLF17 ZSCAN9 HBP1 NFYB ZNF143 RCOR1 RAPGEF1 NTNG2 EIF4A1P3
GH09F132259 1.2 Ensembl ENCODE 10.7 +97.7 97749 0.8 CBX3 SIN3A RAD21 ZNF143 RCOR1 CREM KLF13 DEK EGR2 THAP11 NTNG2 TTF1 RNU5D-2P MED27 SETX GC09M132284
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NTNG2 on UCSC Golden Path with GeneCards custom track

Promoters for NTNG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001316532 448 1801 SUZ12 ZNF223 ZIC2 ZNF2 ZFHX2 POLR2A PATZ1 PRDM10 CREM ZBTB20

Genomic Location for NTNG2 Gene

Chromosome:
9
Start:
132,161,652 bp from pter
End:
132,244,534 bp from pter
Size:
82,883 bases
Orientation:
Plus strand

Genomic View for NTNG2 Gene

Genes around NTNG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTNG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTNG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTNG2 Gene

Proteins for NTNG2 Gene

  • Protein details for NTNG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CW9-NTNG2_HUMAN
    Recommended name:
    Netrin-G2
    Protein Accession:
    Q96CW9
    Secondary Accessions:
    • Q5JUJ2
    • Q6UXY0
    • Q96JH0

    Protein attributes for NTNG2 Gene

    Size:
    530 amino acids
    Molecular mass:
    59799 Da
    Quaternary structure:
    • Interacts with LRRC4.
    SequenceCaution:
    • Sequence=BAB47486.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NTNG2 Gene

    Alternative splice isoforms for NTNG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTNG2 Gene

Post-translational modifications for NTNG2 Gene

No data available for DME Specific Peptides for NTNG2 Gene

Domains & Families for NTNG2 Gene

Gene Families for NTNG2 Gene

Protein Domains for NTNG2 Gene

Suggested Antigen Peptide Sequences for NTNG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CW9

UniProtKB/Swiss-Prot:

NTNG2_HUMAN :
  • The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.
Domain:
  • The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.
  • Contains 3 laminin EGF-like domains.
  • Contains 1 laminin N-terminal domain.
genes like me logo Genes that share domains with NTNG2: view

Function for NTNG2 Gene

Molecular function for NTNG2 Gene

UniProtKB/Swiss-Prot Function:
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Gene Ontology (GO) - Molecular Function for NTNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21946559
genes like me logo Genes that share ontologies with NTNG2: view
genes like me logo Genes that share phenotypes with NTNG2: view

Animal Models for NTNG2 Gene

MGI Knock Outs for NTNG2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NTNG2

miRNA for NTNG2 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTNG2 Gene

Localization for NTNG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTNG2 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTNG2 Gene COMPARTMENTS Subcellular localization image for NTNG2 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for NTNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0030424 axon IEA --
GO:0031225 anchored component of membrane IEA --
GO:0046658 anchored component of plasma membrane ISS --
genes like me logo Genes that share ontologies with NTNG2: view

Pathways & Interactions for NTNG2 Gene

genes like me logo Genes that share pathways with NTNG2: view

Gene Ontology (GO) - Biological Process for NTNG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0007409 axonogenesis ISS --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with NTNG2: view

No data available for SIGNOR curated interactions for NTNG2 Gene

Drugs & Compounds for NTNG2 Gene

(1) Drugs for NTNG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NTNG2: view

Transcripts for NTNG2 Gene

Unigene Clusters for NTNG2 Gene

Netrin G2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTNG2 Gene

No ASD Table

Relevant External Links for NTNG2 Gene

GeneLoc Exon Structure for
NTNG2
ECgene alternative splicing isoforms for
NTNG2

Expression for NTNG2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NTNG2 Gene

mRNA differential expression in normal tissues according to GTEx for NTNG2 Gene

This gene is overexpressed in Whole Blood (x11.1), Brain - Amygdala (x5.1), Brain - Cortex (x4.3), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for NTNG2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NTNG2 Gene



Protein tissue co-expression partners for NTNG2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NTNG2 Gene:

NTNG2

SOURCE GeneReport for Unigene cluster for NTNG2 Gene:

Hs.163642
genes like me logo Genes that share expression patterns with NTNG2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for NTNG2 Gene

Orthologs for NTNG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTNG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTNG2 34 35
  • 98.7 (n)
dog
(Canis familiaris)
Mammalia NTNG2 34 35
  • 94.17 (n)
cow
(Bos Taurus)
Mammalia NTNG2 34 35
  • 93.52 (n)
rat
(Rattus norvegicus)
Mammalia Ntng2 34
  • 89.08 (n)
mouse
(Mus musculus)
Mammalia Ntng2 34 16 35
  • 87.98 (n)
oppossum
(Monodelphis domestica)
Mammalia NTNG2 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTNG2 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves NTNG2 34 35
  • 81.39 (n)
lizard
(Anolis carolinensis)
Reptilia NTNG2 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntng2 34
  • 71.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8729 34
zebrafish
(Danio rerio)
Actinopterygii ntng2a 34 35
  • 70.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta NetA 35
  • 18 (a)
ManyToMany
NetB 35
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea unc-6 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 28 (a)
OneToMany
Species where no ortholog for NTNG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTNG2 Gene

ENSEMBL:
Gene Tree for NTNG2 (if available)
TreeFam:
Gene Tree for NTNG2 (if available)

Paralogs for NTNG2 Gene

Paralogs for NTNG2 Gene

(1) SIMAP similar genes for NTNG2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NTNG2: view

Variants for NTNG2 Gene

Sequence variations from dbSNP and Humsavar for NTNG2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10114567 -- 132,181,604(+) GCCAC(C/T)GTGCC intron-variant
rs10116734 -- 132,180,304(+) CCTCC(A/G)CCAAG intron-variant
rs10116759 -- 132,180,427(+) CTGTT(A/C)ATCCA intron-variant
rs10117408 -- 132,180,497(+) AGTTC(C/T)GGGGC intron-variant
rs10117460 -- 132,189,749(+) attct(C/T)gtgcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTNG2 Gene

Variant ID Type Subtype PubMed ID
esv1610785 CNV insertion 17803354
esv2739125 CNV deletion 23290073
esv5554 CNV gain 19470904
nsv1035219 CNV gain 25217958
nsv1041246 CNV gain 25217958
nsv1049356 CNV gain 25217958
nsv1132985 CNV insertion 24896259
nsv1161912 CNV deletion 26073780
nsv416829 CNV insertion 16902084
nsv416962 CNV insertion 16902084
nsv469904 CNV loss 18288195
nsv509328 CNV insertion 20534489
nsv519872 CNV loss 19592680
nsv527281 CNV loss 19592680
nsv528123 CNV loss 19592680
nsv528270 CNV loss 19592680
nsv615571 CNV loss 21841781
nsv615572 CNV gain 21841781
nsv6739 CNV insertion 18451855
nsv6740 CNV insertion 18451855
nsv825134 CNV gain 20364138
nsv951793 CNV deletion 24416366
nsv951794 CNV deletion 24416366

Variation tolerance for NTNG2 Gene

Residual Variation Intolerance Score: 11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTNG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NTNG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTNG2 Gene

Disorders for NTNG2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NTNG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rett syndrome
  • rett syndrome, preserved speech variant
- elite association - COSMIC cancer census association via MalaCards
Search NTNG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NTNG2

Genetic Association Database (GAD)
NTNG2
Human Genome Epidemiology (HuGE) Navigator
NTNG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NTNG2
genes like me logo Genes that share disorders with NTNG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTNG2 Gene

Publications for NTNG2 Gene

  1. Structural basis for cell surface patterning through NetrinG-NGL interactions. (PMID: 21946559) Seiradake E. … Jones E.Y. (EMBO J. 2011) 3 4 64
  2. Crystal structure of the ligand binding domain of netrin G2. (PMID: 22041449) Brasch J. … Shapiro L. (J. Mol. Biol. 2011) 3 4 64
  3. Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. (PMID: 17507910) Eastwood S.L. … Harrison P.J. (Neuropsychopharmacology 2008) 3 22 64
  4. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. (PMID: 18204098) Hom G. … Behrens T.W. (N. Engl. J. Med. 2008) 3 46 64
  5. A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. (PMID: 15705354) Aoki-Suzuki M. … Yoshikawa T. (Biol. Psychiatry 2005) 3 22 64

Products for NTNG2 Gene

Sources for NTNG2 Gene

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