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NTNG2 Gene

protein-coding   GIFtS: 59
GCID: GC09P135037

Netrin G2

(Previous name: netrin G1)
(Previous symbol: NTNG1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Netrin G21 2     BA479K20.1 (Novel Protein)2
NTNG11 2     Laminet 22
Netrin G11 2     laminet-22
Netrin-G21     netrin-G22
LHLL93812     KIAA18573
Lmnt22     LMNT23
bA479K20.12     Laminet-23

External Ids:    HGNC: 142881   Entrez Gene: 846282   Ensembl: ENSG000001963587   UniProtKB: Q96CW93   

Export aliases for NTNG2 gene to outside databases

Previous GC identifers: GC09P130318 GC09P132066 GC09P134026 GC09P104523


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NTNG2 Gene:
NTNG2 (netrin G2) is a protein-coding gene. Diseases associated with NTNG2 include rett syndrome, and temporal lobe epilepsy. An important paralog of this gene is NTN1.

UniProtKB/Swiss-Prot: NTNG2_HUMAN, Q96CW9
Function: Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular
and synaptic levels. Promotes neurite outgrowth of both axons and dendrites

Gene Wiki entry for NTNG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NTNG2 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   C/EBPalpha   AREB6   CHOP-10   E2F   E2F-1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for NTNG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTNG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.13   HGNC cytogenetic band: 9q34

NTNG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTNG2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P135037:  view genomic region     (about GC identifiers)

Start:
135,037,334 bp from pter      End:
135,119,921 bp from pter
Size:
82,588 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NTNG2_HUMAN, Q96CW9 (See protein sequence)
Recommended Name: Netrin-G2 precursor  
Size: 530 amino acids; 59799 Da
Subunit: Interacts with LRRC4 (By similarity)
Sequence caution: Sequence=BAB47486.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for NTNG2:
3TBD (3D)        3ZYG (3D)        3ZYI (3D)    
Secondary accessions: Q5JUJ2 Q6UXY0 Q96JH0
Alternative splicing: 2 isoforms:  Q96CW9-1   Q96CW9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NTNG2: NX_Q96CW9

Explore proteomics data for NTNG2 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Glycosylation2 at Asn122, Asn128, Asn310, Asn395, Asn422
  • Modification sites at PhosphoSitePlus

  • See NTNG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115925.2  
    ENSEMBL proteins: 
     ENSP00000376921   ENSP00000353888   ENSP00000376920   ENSP00000361252  

    NTNG2 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NTNG2
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    Novus Biologicals NTNG2 Protein
    Novus Biologicals NTNG2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    NTNG2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    NTNG2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NTN: Netrins

    4 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR008211 Laminin_N
     IPR013032 EGF-like_CS
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry Q96CW9

    ProtoNet protein and cluster: Q96CW9

    1 Blocks protein domain: IPB002049 Laminin-type EGF-like domain

    UniProtKB/Swiss-Prot: NTNG2_HUMAN, Q96CW9
    Domain: The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three
    NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR
    repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface
    subdomains
    Similarity: Contains 3 laminin EGF-like domains
    Similarity: Contains 1 laminin N-terminal domain


    NTNG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTNG2_HUMAN, Q96CW9
    Function: Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular
    and synaptic levels. Promotes neurite outgrowth of both axons and dendrites

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI--
         
    NTNG2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NTNG2:
     Decreased viability with pacli 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ntng2):
     behavior/neurological  hearing/vestibular/ear  mortality/aging 

    NTNG2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NTNG2: Ntng2tm1Ito Ntng2tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NTNG2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NTNG2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTNG2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTNG2

    miRNA
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    miRTarBase miRNAs that target NTNG2:
    hsa-mir-26b-5p (MIRT029912)

    Block miRNA regulation of human, mouse, rat NTNG2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate NTNG2:
    hsa-miR-148b* hsa-miR-3168 hsa-miR-629* hsa-miR-2117
    SwitchGear 3'UTR luciferase reporter plasmidNTNG2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NTNG2
    Predesigned siRNA for gene silencing in human, mouse, rat NTNG2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: NTNG2 (NM_032536)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTNG2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NTNG2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTNG2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NTNG2_HUMAN, Q96CW9: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytosol1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0046658anchored component of plasma membrane ISS--

    NTNG2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NTNG2 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)
    2Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for NTNG2):
        Axon guidance
    Cell adhesion molecules (CAMs)


    NTNG2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NTNG2
    Interactions:

        Search GeneGlobe Interaction Network for NTNG2

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for NTNG2 (Q96CW91, 2, 3 ENSP000003769214) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRRC4CQ9HCJ21, 2EBI-750795,EBI-3925442 MINT-8300885 MINT-8300842
    LRRC4Q9HBW11, 2, ENSP000002493634EBI-750795,EBI-7444327 MINT-8300800 MINT-8300766 MINT-8300722 MINT-8300489 STRING: ENSP00000249363
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    SHCBP1Q8NEM23I2D: score=1 
    --Q96MX43I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007409axonogenesis ISS--

    NTNG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NTNG2

    1 Novoseek inferred chemical compound relationship for NTNG2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nmda 39.6 1 16502428 (1)



    NTNG2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NTNG2 gene: 
    NM_032536.2  

    Unigene Cluster for NTNG2:

    Netrin G2
    Hs.163642  [show with all ESTs]
    Unigene Representative Sequence: AY358165
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393229(uc004cbh.2) ENST00000490694 ENST00000483055 ENST00000360670
    ENST00000393228 ENST00000372179
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NTNG2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate NTNG2:
    hsa-miR-148b* hsa-miR-3168 hsa-miR-629* hsa-miR-2117
    SwitchGear 3'UTR luciferase reporter plasmidNTNG2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NTNG2
    Predesigned siRNA for gene silencing in human, mouse, rat NTNG2
    Clone
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    GenScript: all cDNA clones in your preferred vector: NTNG2 (NM_032536)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTNG2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTNG2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NTNG2
    OriGene qSTAR qPCR primer pairs in human, mouse for NTNG2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat NTNG2
      QuantiTect SYBR Green Assays in human, mouse, rat NTNG2
      QuantiFast Probe-based Assays in human, mouse, rat NTNG2

    Additional mRNA sequence: 

    AB058760.2 AF131842.1 AY358165.1 BC013770.1 

    4 DOTS entries:

    DT.75141862  DT.100747266  DT.97835561  DT.97813455 

    Selected AceView cDNA sequences (see all 37):

    BX279957 BF930108 BX281558 BM930930 BM126382 AB058760 BQ894522 BX099434 
    AY358165 BM053055 NM_032536 T11457 BM547925 CK903969 BI031197 BC013770 
    BU159259 BM684442 AF131842 BF338562 BM932044 H83980 BF791911 CA393159 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NTNG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTCTCCCAA
    NTNG2 Expression
    About this image


    NTNG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
             Floor plate-like cells
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Eye (Sensory Organs)
    NTNG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NTNG2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.163642
        Custom PCR Arrays for NTNG2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTNG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NTNG2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntng21 , 5 netrin G21, 5 87.98(n)1
    93.57(a)1
      2 (19.57 cM)5
    1711711  NM_133501.11  NP_598008.11 
     291945415 
    chicken
    (Gallus gallus)
    Aves NTNG21 netrin G2 81.39(n)
    84.22(a)
      417171  XM_004945906.1  XP_004945963.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTNG26
    netrin G2
    70(a)
    1 ↔ 1
    GL343812.1(183231-201709)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87292 Xenopus laevis transcribed sequence with weak similarity more 81.53(n)    AW159335.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntng2a1 netrin g2a 70.13(n)
    70.47(a)
      560014  XM_683405.3  XP_688497.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta NetA6
    NetB6
    Netrin-B
    18(a)
    16(a)
    many ↔ many
    many ↔ many
    X(14498045-14547864)
    X(14580071-14643409)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-66
    Protein UNC-6 (unc-6) mRNA, complete cds
    21(a)
    1 → many
    X(6889689-6897140) WBGene00006746


    ENSEMBL Gene Tree for NTNG2 (if available)
    TreeFam Gene Tree for NTNG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NTNG2 gene
    NTN12  NTNG12  NTN32  LAMB32  NTN42  NTN52  
    1 SIMAP similar gene for NTNG2 using alignment to 3 protein entries:     NTNG2_HUMAN (see all proteins):
    NTNG1

    NTNG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NTNG2 (see all 1824)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112436491,2
    F,H--135035376(+) GCTGAG/ATGCTT 1 -- us2k15Minor allele frequency- A:0.24NS EA WA 496
    rs112436501,2
    C,F,H--135035602(+) TCTCAC/TATATG 1 -- us2k111Minor allele frequency- T:0.05NS EA NA CSA WA 1206
    rs735592721,2
    C,F--135035637(+) TGGGCG/CGTGTT 1 -- us2k11Minor allele frequency- C:0.50WA 2
    rs1886103481,2
    C--135035710(+) TCCCCA/GGCCAC 1 -- us2k10--------
    rs2016882131,2
    --135035874(+) AAATA-/TATTATTA 1 -- us2k10--------
    rs1927167511,2
    --135035971(+) ACTCCA/GTCTCC 1 -- us2k10--------
    rs795417141,2
    C,F--135035994(+) AGCTGA/GGAACA 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs665800361,2
    C,F--135036019(+) TGGAGG/ATGAAG 1 -- us2k16Minor allele frequency- A:0.15NA CSA WA EA 364
    rs1507674661,2
    --135036050(+) CTGAGA/GTGCCA 1 -- us2k10--------
    rs787651261,2
    C,F--135036320(+) TGCCGG/AATATG 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for NTNG2 (135037334 - 135119921 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NTNG2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2739125CNV Deletion23290073
    nsv416829CNV Insertion16902084
    nsv6739CNV Insertion18451855
    nsv509328CNV Insertion20534489
    esv1610785CNV Insertion17803354
    nsv6740CNV Insertion18451855
    nsv416962CNV Insertion16902084
    nsv469904CNV Loss18288195
    dgv8318n71CNV Loss21882294
    nsv894019CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NTNG2
    DNA2.0 Custom Variant and Variant Library Synthesis for NTNG2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    8 diseases for NTNG2:    
    About MalaCards
    rett syndrome    temporal lobe epilepsy    bipolar disorder    schizophrenia
    systemic lupus erythematosus    lupus erythematosus    cerebritis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for NTNG2:
    Rett syndrome

    NTNG2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NTNG2
    Human Genome Epidemiology (HuGE) Navigator: NTNG2 (1 document)

    Export disorders for NTNG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NTNG2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with NTNG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of the ligand binding domain of netrin G2. (PubMed id 22041449)1, 2 Brasch J.... Shapiro L. (J. Mol. Biol. 2011)
    2. Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. (PubMed id 18204098)1, 4 Hom G....Behrens T.W. (N. Engl. J. Med. 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    6. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    7. Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. (PubMed id 17507910)1, 9 Eastwood S.L. and Harrison P.J. (Neuropsychopharmacology 2008)
    8. A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. (PubMed id 15705354)1, 9 Aoki-Suzuki M....Yoshikawa T. (Biol. Psychiatry 2005)
    9. Topography of Gng2- and NetrinG2-expression suggests an insular origin of the human claustrum. (PubMed id 22957104)1 Pirone A....Castagna M. (PLoS ONE 2012)
    10. Structural basis for cell surface patterning through NetrinG-NGL interactions. (PubMed id 21946559)2 Seiradake E.... Jones E.Y. (EMBO J. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84628 HGNC: 14288 AceView: NTNG2 Ensembl:ENSG00000196358 euGenes: HUgn84628
    ECgene: NTNG2 Kegg: 84628 H-InvDB: NTNG2

    (According to HUGE)
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    HUGE: KIAA1857

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NTNG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NTNG2 gene:
    Search GeneIP for patents involving NTNG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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