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Aliases for NTNG2 Gene

Aliases for NTNG2 Gene

  • Netrin G2 2 3 5
  • Netrin G1 2 3
  • Laminet-2 3 4
  • Lmnt2 3 4
  • BA479K20.1 (Novel Protein) 3
  • BA479K20.1 3
  • Netrin-G2 2
  • Laminet 2 3
  • LHLL9381 3
  • KIAA1857 4
  • NTNG1 3

External Ids for NTNG2 Gene

Previous HGNC Symbols for NTNG2 Gene

  • NTNG1

Previous GeneCards Identifiers for NTNG2 Gene

  • GC09P130318
  • GC09P132066
  • GC09P134026
  • GC09P135037
  • GC09P104523

Summaries for NTNG2 Gene

GeneCards Summary for NTNG2 Gene

NTNG2 (Netrin G2) is a Protein Coding gene. Diseases associated with NTNG2 include partial fetal alcohol syndrome and rett syndrome. Among its related pathways are Axon guidance and Cell adhesion molecules (CAMs). An important paralog of this gene is NTN3.

UniProtKB/Swiss-Prot for NTNG2 Gene

  • Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Gene Wiki entry for NTNG2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTNG2 Gene

Genomics for NTNG2 Gene

Regulatory Elements for NTNG2 Gene

Promoters for NTNG2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NTNG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NTNG2 Gene

Chromosome:
9
Start:
132,161,652 bp from pter
End:
132,244,534 bp from pter
Size:
82,883 bases
Orientation:
Plus strand

Genomic View for NTNG2 Gene

Genes around NTNG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTNG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTNG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTNG2 Gene

Proteins for NTNG2 Gene

  • Protein details for NTNG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CW9-NTNG2_HUMAN
    Recommended name:
    Netrin-G2
    Protein Accession:
    Q96CW9
    Secondary Accessions:
    • Q5JUJ2
    • Q6UXY0
    • Q96JH0

    Protein attributes for NTNG2 Gene

    Size:
    530 amino acids
    Molecular mass:
    59799 Da
    Quaternary structure:
    • Interacts with LRRC4.
    SequenceCaution:
    • Sequence=BAB47486.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NTNG2 Gene

    Alternative splice isoforms for NTNG2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTNG2 Gene

Proteomics data for NTNG2 Gene at MOPED

Post-translational modifications for NTNG2 Gene

Other Protein References for NTNG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NTNG2 Gene

Domains & Families for NTNG2 Gene

Gene Families for NTNG2 Gene

Protein Domains for NTNG2 Gene

Suggested Antigen Peptide Sequences for NTNG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CW9

UniProtKB/Swiss-Prot:

NTNG2_HUMAN :
  • The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.
Domain:
  • The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.
  • Contains 3 laminin EGF-like domains.
  • Contains 1 laminin N-terminal domain.
genes like me logo Genes that share domains with NTNG2: view

Function for NTNG2 Gene

Molecular function for NTNG2 Gene

UniProtKB/Swiss-Prot Function:
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.
genes like me logo Genes that share phenotypes with NTNG2: view

Animal Models for NTNG2 Gene

MGI Knock Outs for NTNG2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NTNG2

miRNA for NTNG2 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTNG2 Gene

Localization for NTNG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTNG2 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTNG2 Gene COMPARTMENTS Subcellular localization image for NTNG2 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NTNG2 Gene

Pathways & Interactions for NTNG2 Gene

genes like me logo Genes that share pathways with NTNG2: view

Pathways by source for NTNG2 Gene

2 KEGG pathways for NTNG2 Gene

Gene Ontology (GO) - Biological Process for NTNG2 Gene

None

No data available for SIGNOR curated interactions for NTNG2 Gene

Drugs & Compounds for NTNG2 Gene

(1) Drugs for NTNG2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with NTNG2: view

Transcripts for NTNG2 Gene

Unigene Clusters for NTNG2 Gene

Netrin G2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTNG2 Gene

No ASD Table

Relevant External Links for NTNG2 Gene

GeneLoc Exon Structure for
NTNG2
ECgene alternative splicing isoforms for
NTNG2

Expression for NTNG2 Gene

mRNA expression in normal human tissues for NTNG2 Gene

mRNA differential expression in normal tissues according to GTEx for NTNG2 Gene

This gene is overexpressed in Whole Blood (x11.1), Brain - Amygdala (x5.1), Brain - Cortex (x4.3), and Brain - Hippocampus (x4.2).

Protein differential expression in normal tissues from HIPED for NTNG2 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NTNG2 Gene



SOURCE GeneReport for Unigene cluster for NTNG2 Gene Hs.163642

genes like me logo Genes that share expression patterns with NTNG2: view

Protein tissue co-expression partners for NTNG2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NTNG2 Gene

Orthologs for NTNG2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTNG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTNG2 36
  • 100 (a)
OneToOne
NTNG2 35
  • 98.7 (n)
  • 98.82 (a)
cow
(Bos Taurus)
Mammalia NTNG2 36
  • 85 (a)
OneToOne
NTNG2 35
  • 93.52 (n)
  • 96.39 (a)
dog
(Canis familiaris)
Mammalia NTNG2 35
  • 94.17 (n)
  • 96.85 (a)
NTNG2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntng2 36
  • 85 (a)
OneToOne
Ntng2 16
Ntng2 35
  • 87.98 (n)
  • 93.57 (a)
oppossum
(Monodelphis domestica)
Mammalia NTNG2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTNG2 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntng2 35
  • 89.08 (n)
  • 95.13 (a)
chicken
(Gallus gallus)
Aves NTNG2 35
  • 81.39 (n)
  • 84.22 (a)
NTNG2 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTNG2 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8729 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ntng2 35
  • 71.42 (n)
  • 75.8 (a)
zebrafish
(Danio rerio)
Actinopterygii ntng2a 36
  • 28 (a)
OneToOne
ntng2a 35
  • 70.13 (n)
  • 70.47 (a)
fruit fly
(Drosophila melanogaster)
Insecta NetA 36
  • 18 (a)
ManyToMany
NetB 36
  • 16 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea unc-6 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for NTNG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTNG2 Gene

ENSEMBL:
Gene Tree for NTNG2 (if available)
TreeFam:
Gene Tree for NTNG2 (if available)

Paralogs for NTNG2 Gene

Paralogs for NTNG2 Gene

(1) SIMAP similar genes for NTNG2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NTNG2: view

Variants for NTNG2 Gene

Sequence variations from dbSNP and Humsavar for NTNG2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs4962173 - 132,230,577(+) GTGCC(A/G)CTGCA upstream-variant-2KB, reference, missense
rs869497 -- 132,163,667(+) CCTCC(C/G)GTGCC intron-variant, upstream-variant-2KB
rs876952 -- 132,244,085(+) CAGGA(C/G)TGATG utr-variant-3-prime
rs876953 -- 132,244,197(+) CCTCT(A/G)CTCTT utr-variant-3-prime
rs1111393 -- 132,239,006(+) CAGGG(A/C/G)CGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTNG2 Gene

Variant ID Type Subtype PubMed ID
nsv509328 CNV Insertion 20534489
dgv8318n71 CNV Loss 21882294
nsv6739 CNV Insertion 18451855
dgv8319n71 CNV Loss 21882294
nsv825134 CNV Gain 20364138
nsv519872 CNV Loss 19592680
nsv416829 CNV Insertion 16902084
esv1610785 CNV Insertion 17803354
nsv416962 CNV Insertion 16902084
esv2739125 CNV Deletion 23290073
nsv894018 CNV Gain 21882294
nsv894019 CNV Loss 21882294
esv5554 CNV Gain 19470904
nsv528270 CNV Loss 19592680
nsv527281 CNV Loss 19592680
nsv528123 CNV Loss 19592680
nsv6740 CNV Insertion 18451855
nsv469904 CNV Loss 18288195

Variation tolerance for NTNG2 Gene

Residual Variation Intolerance Score: 11.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.84; 34.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTNG2 Gene

HapMap Linkage Disequilibrium report
NTNG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTNG2 Gene

Disorders for NTNG2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NTNG2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
partial fetal alcohol syndrome
rett syndrome
  • rett syndrome, preserved speech variant
- elite association - COSMIC cancer census association via MalaCards
Search NTNG2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NTNG2

Genetic Association Database (GAD)
NTNG2
Human Genome Epidemiology (HuGE) Navigator
NTNG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NTNG2
genes like me logo Genes that share disorders with NTNG2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTNG2 Gene

Publications for NTNG2 Gene

  1. Structural basis for cell surface patterning through NetrinG-NGL interactions. (PMID: 21946559) Seiradake E. … Jones E.Y. (EMBO J. 2011) 3 4 67
  2. Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. (PMID: 17507910) Eastwood S.L. … Harrison P.J. (Neuropsychopharmacology 2008) 3 23
  3. A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. (PMID: 15705354) Aoki-Suzuki M. … Yoshikawa T. (Biol. Psychiatry 2005) 3 23
  4. Topography of Gng2- and NetrinG2-expression suggests an insular origin of the human claustrum. (PMID: 22957104) Pirone A. … Castagna M. (PLoS ONE 2012) 3
  5. Crystal structure of the ligand binding domain of netrin G2. (PMID: 22041449) Brasch J. … Shapiro L. (J. Mol. Biol. 2011) 3

Products for NTNG2 Gene

Sources for NTNG2 Gene

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