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NTNG1 Gene

protein-coding   GIFtS: 55
GCID: GC01P107682

Netrin G1

  See NTNG1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Netrin G11 2     YLSR5712
Netrin G1f1 2     Axon Guidance Molecule2
KIAA09763 5     Laminet 12
LMNT13 5     laminet-12
Netrin-G11     netrin-G12
Lmnt12     Laminet-13

External Ids:    HGNC: 233191   Entrez Gene: 228542   Ensembl: ENSG000001626317   OMIM: 6088185   UniProtKB: Q9Y2I23   

Export aliases for NTNG1 gene to outside databases

Previous GC identifers: GC00U990862 GC09P128391 GC01P107038 GC01P107395 GC01P107484 GC01P105628


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NTNG1 Gene:
Netrin G1 (NTNG1) belongs to a conserved family of proteins that act as axon guidance cues during vertebrate
nervous system development (Nakashiba et al., 2000 (PubMed 10964959)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NTNG1 Gene:
NTNG1 (netrin G1) is a protein-coding gene. Diseases associated with NTNG1 include epileptic encephalopathy, early infantile, 2, and atypical rett syndrome. An important paralog of this gene is NTN1.

UniProtKB/Swiss-Prot: NTNG1_HUMAN, Q9Y2I2
Function: Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular
and synaptic levels. Promotes neurite outgrowth of both axons and dendrites

Gene Wiki entry for NTNG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NTNG1 gene promoter:
         p53   NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTNG1 promoter sequence
   Search Chromatin IP Primers for NTNG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTNG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.2-p13.1

NTNG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTNG1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P107682:  view genomic region     (about GC identifiers)

Start:
107,682,629 bp from pter      End:
108,026,080 bp from pter
Size:
343,452 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: NTNG1_HUMAN, Q9Y2I2 (See protein sequence)
Recommended Name: Netrin-G1 precursor  
Size: 539 amino acids; 60541 Da
Subunit: Interacts with NGL1
Sequence caution: Sequence=BAA76820.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for NTNG1:
3ZYJ (3D)    
Secondary accessions: Q5VU86 Q5VU87 Q5VU89 Q5VU90 Q5VU91 Q7Z2Y3 Q8N633
Alternative splicing: 6 isoforms:  Q9Y2I2-3   Q9Y2I2-2   Q9Y2I2-1   Q9Y2I2-4   Q9Y2I2-5   Q9Y2I2-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NTNG1: NX_Q9Y2I2

Explore proteomics data for NTNG1 at MOPED

Post-translational modifications: 

  • N-glycosylated (By similarity)1
  • Modification sites at neXtProt

  • See NTNG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_055732.2  NP_001106697.1  NP_001106699.1  

    ENSEMBL proteins: 
     ENSP00000359091   ENSP00000359085   ENSP00000359084   ENSP00000359083   ENSP00000359082  
     ENSP00000359090   ENSP00000359088   ENSP00000440561   ENSP00000359078   ENSP00000359089  
     ENSP00000359087  

    NTNG1 Human Recombinant Protein Products:

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    Novus Biologicals NTNG1 Protein
    Novus Biologicals NTNG1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NTNG1 

     
    antibodies-online proteins for NTNG1 (4 products) 

     
    antibodies-online peptides for NTNG1

    NTNG1 Antibody Products:

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    antibodies-online antibodies for NTNG1 (11 products) 

    NTNG1 Assay Products:

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    antibodies-online kits for NTNG1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NTN: Netrins

    4 InterPro protein domains:
     IPR000742 EG-like_dom
     IPR008211 Laminin_N
     IPR013032 EGF-like_CS
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry Q9Y2I2

    ProtoNet protein and cluster: Q9Y2I2

    1 Blocks protein domain: IPB006210 Type I EGF

    UniProtKB/Swiss-Prot: NTNG1_HUMAN, Q9Y2I2
    Domain: The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three
    NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR
    repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface
    subdomains
    Similarity: Contains 3 laminin EGF-like domains
    Similarity: Contains 1 laminin N-terminal domain


    Find genes that share domains with NTNG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTNG1_HUMAN, Q9Y2I2
    Function: Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular
    and synaptic levels. Promotes neurite outgrowth of both axons and dendrites

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14595443
         
    Find genes that share ontologies with NTNG1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ntng1):
     mortality/aging  nervous system 

    Find genes that share phenotypes with NTNG1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for NTNG1

    miRNA
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    miRTarBase miRNAs that target NTNG1:
    hsa-mir-26b-5p (MIRT029912)

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    Selected qRT-PCR Assays for microRNAs that regulate NTNG1 (see all 43):
    hsa-miR-411* hsa-miR-579 hsa-miR-3194-5p hsa-miR-379* hsa-miR-30d hsa-miR-219-5p hsa-miR-632 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidNTNG1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for NTNG1
    Predesigned siRNA for gene silencing in human, mouse, rat NTNG1

    Gene Editing
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    OriGene ORF clones in mouse, rat for NTNG1
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    GenScript: all cDNA clones in your preferred vector (see all 3): NTNG1 (NM_001113228)
    Sino Biological Human cDNA Clone for NTNG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTNG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTNG1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NTNG1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTNG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NTNG1_HUMAN, Q9Y2I2: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2
    peroxisome2
    cytosol1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane ----
    GO:0046658anchored component of plasma membrane ISS--

    Find genes that share ontologies with NTNG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NTNG1 About    
    See pathways by source

    SuperPathContained pathways About
    1Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)
    2Axon guidance
    Axon guidance


    Find genes that share SuperPaths with NTNG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for NTNG1):
        Axon guidance
    Cell adhesion molecules (CAMs)

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NTNG1
    Interactions:

        Search GeneGlobe Interaction Network for NTNG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for NTNG1 (Q9Y2I21, 2, 3 ENSP000003590854) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRRC4CQ9HCJ21, 2, 3, ENSP000002781984EBI-7444396,EBI-3925442 MINT-8301036 MINT-8301082 MINT-8300711 MINT-8300986 I2D: score=2 STRING: ENSP00000278198
    LRRC4Q9HBW11, 2EBI-7444396,EBI-7444327 MINT-8301004 MINT-8301057
    SLC25A24ENSP000002641284STRING: ENSP00000264128
    TUBGCP2ENSP000002529364STRING: ENSP00000252936
    TUBGCP3ENSP000002619654STRING: ENSP00000261965
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007409axonogenesis ISS--

    Find genes that share ontologies with NTNG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NTNG1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NTNG1 gene (3 alternative transcripts): 
    NM_014917.2  NM_001113226.1  NM_001113228.1  

    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370074(uc009wem.3) ENST00000370068(uc001dvi.3 uc001dve.3 uc009wek.3)
    ENST00000294649(uc001dvd.1) ENST00000370067(uc001dvg.3) ENST00000462149
    ENST00000370076 ENST00000370066 ENST00000370065 ENST00000477948 ENST00000370073(uc001dvh.4 uc010out.2)
    ENST00000370071(uc001dvf.4 uc001dvc.4) ENST00000542803 ENST00000370061
    ENST00000370072 ENST00000370070
    miRNA
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    Block miRNA regulation of human, mouse, rat NTNG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NTNG1 (see all 43):
    hsa-miR-411* hsa-miR-579 hsa-miR-3194-5p hsa-miR-379* hsa-miR-30d hsa-miR-219-5p hsa-miR-632 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidNTNG1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NTNG1
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    Primer
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    OriGene qPCR primer pairs and template standards for NTNG1
    OriGene qSTAR qPCR primer pairs in human, mouse for NTNG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NTNG1
      QuantiTect SYBR Green Assays in human, mouse, rat NTNG1
      QuantiFast Probe-based Assays in human, mouse, rat NTNG1

    Selected AceView cDNA sequences (see all 51):

    AW241931 BX538348 BE699190 BC030220 AI435585 CR594836 BU728093 AW085292 
    BX105933 AA422028 CK299898 CA395310 AI140857 AY358365 BM983914 AI858128 
    BG217958 CB854263 AA621162 BX377397 AB023193 AI351769 AI742127 AI220610 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NTNG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NTNG1 Expression
    About this image


    NTNG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Mandibular Process
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
     
     Neural Tube (Nervous System)
             Floor plate-like cells
    NTNG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NTNG1 Protein Expression

    UniProtKB/Swiss-Prot: NTNG1_HUMAN, Q9Y2I2
    Tissue specificity: Highly expressed in the thalamus, with very low expression, if any, in other tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTNG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for NTNG1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntng11 , 5 netrin G11, 5 92.15(n)1
    96.47(a)1
      3 (48.47 cM)5
    808831  NM_030699.21  NP_109624.11 
     1097800405 
    chicken
    (Gallus gallus)
    Aves NTNG11 netrin G1 83.82(n)
    88.44(a)
      424336  XM_004943079.1  XP_004943136.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTNG16
    netrin G1
    86(a)
    1 ↔ 1
    4(83659320-83659949)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ntng11 netrin G1 71.89(n)
    73.39(a)
      100494090  XM_004913752.1  XP_004913809.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntng11 netrin G1 70.12(n)
    74.21(a)
      569075  XM_005162829.1  XP_005162886.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NetA6
    NetB6
    Netrin-B
    19(a)
    18(a)
    many ↔ many
    many ↔ many
    X(14498045-14547864)
    X(14580071-14643409)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-66
    Protein UNC-6 (unc-6) mRNA, complete cds
    24(a)
    1 → many
    X(6889689-6897140) WBGene00006746


    ENSEMBL Gene Tree for NTNG1 (if available)
    TreeFam Gene Tree for NTNG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NTNG1 gene
    NTN12  NTN32  LAMB32  NTN42  NTN52  NTNG22  
    5 SIMAP similar genes for NTNG1 using alignment to 14 protein entries:     NTNG1_HUMAN (see all proteins):
    NTNG2    VWDE    NELL1    NTN1    NOTCH3

    Find genes that share paralogs with NTNG1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NTNG1 (see all 6669)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1148723071,2
    C,F--107680699(+) AAGCTG/CGTTTA 2 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1403650921,2
    C--107680775(+) CCTTAC/TCACCT 3 -- us2k10--------
    rs1812230681,2
    --107680792(+) TGCTGA/GAGGAG 3 -- us2k10--------
    rs1157502871,2
    C,F--107681070(+) TGATAC/TAGGAA 3 -- us2k11Minor allele frequency- T:0.01WA 118
    rs45422381,2
    H--107681102(+) CAAGAT/CTTTGA 3 -- us2k14Minor allele frequency- C:0.00NS EA 420
    rs1435521261,2
    C--107681166(+) GTATAC/TTCCAG 3 -- us2k10--------
    rs1140898751,2
    C,F--107681202(+) GATTTA/GTTTTA 3 -- us2k11Minor allele frequency- G:0.01NA 120
    rs127508681,2
    C,H--107681314(+) TGAGAA/CCTGTC 3 -- us2k14Minor allele frequency- C:0.00NS EA 420
    rs1853663421,2
    --107681329(+) TTTCAA/GGATCT 3 -- us2k10--------
    rs127299091,2
    H--107681364(+) AGAAGG/CCCACT 3 -- us2k14Minor allele frequency- C:0.00NS EA 418

    HapMap Linkage Disequilibrium report for NTNG1 (107682629 - 107932629 bp, first 250kb of NTNG1)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for NTNG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678975CNV Deletion23128226
    esv2676966CNV Deletion23128226
    esv2674592CNV Deletion23128226
    nsv521184CNV Loss19592680
    nsv508033CNV Loss20534489
    nsv830982CNV Gain17160897
    nsv830993CNV Gain17160897
    essv19382CNV CNV17122850
    essv24194CNV CNV17122850
    dgv82e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): NTNG1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NTNG1
    DNA2.0 Custom Variant and Variant Library Synthesis for NTNG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608818    OMIM disorders: --

    2 diseases for NTNG1:    
    About MalaCards
    epileptic encephalopathy, early infantile, 2    atypical rett syndrome

    1 disease from the University of Copenhagen DISEASES database for NTNG1:
    Rett syndrome

    Find genes that share disorders with NTNG1           About GenesLikeMe

    Genetic Association Database (GAD): NTNG1
    Human Genome Epidemiology (HuGE) Navigator: NTNG1 (13 documents)

    Export disorders for NTNG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NTNG1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with NTNG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human netrin-G1 isoforms show evidence of differential expression. (PubMed id 15901489)1, 2, 9 Meerabux J.M.... Yoshikawa T. (Genomics 2005)
    2. A genome-wide association study on common SNPs and rare CNVs in anorexia nervosa. (PubMed id 21079607)1, 4 Wang K....Hakonarson H. (Mol. Psychiatry 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    6. Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease. (PubMed id 18628988)1, 4 Li Y....Hadjigeorgiou G. (PLoS ONE 2008)
    7. Association of polymorphisms in the haplotype block spanning the alternatively spliced exons of the NTNG1 gene at 1p13.3 with schizophrenia in Japanese populations. (PubMed id 18384956)1, 4 Ohtsuki T....Arinami T. (Neurosci. Lett. 2008)
    8. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    9. Case-control association study of human netrin G1 gene in Japanese schizophrenia. (PubMed id 15508520)1, 4 Fukasawa M....Yoshikawa T. (J. Med. Dent. Sci. 2004)
    10. Fc receptor gamma subunit polymorphisms and systemic lupus erythematosus. (PubMed id 15494819)1, 4 Alansari A....Hajeer A.H. (Saudi Med J 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22854 HGNC: 23319 AceView: NTNG1 Ensembl:ENSG00000162631 euGenes: HUgn22854
    ECgene: NTNG1 Kegg: 22854 H-InvDB: NTNG1

    (According to HUGE)
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    HUGE: KIAA0976

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NTNG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NTNG1 gene:
    Search GeneIP for patents involving NTNG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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