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Aliases for NTNG1 Gene

Aliases for NTNG1 Gene

  • Netrin G1 2 3
  • Lmnt1 3 4
  • Axon Guidance Molecule 3
  • Netrin G1f 2
  • Netrin-G1 2
  • Laminet 1 3
  • Laminet-1 4
  • KIAA0976 4

External Ids for NTNG1 Gene

Previous GeneCards Identifiers for NTNG1 Gene

  • GC00U990862
  • GC09P128391
  • GC01P107038
  • GC01P107395
  • GC01P107484
  • GC01P107682
  • GC01P105628

Summaries for NTNG1 Gene

Entrez Gene Summary for NTNG1 Gene

  • This gene encodes a preproprotein that is processed into a secreted protein containing eukaroytic growth factor (EGF)-like domains. This protein acts to guide axon growth during neuronal development. Polymorphisms in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2015]

GeneCards Summary for NTNG1 Gene

NTNG1 (Netrin G1) is a Protein Coding gene. Diseases associated with NTNG1 include partial fetal alcohol syndrome and rett syndrome. Among its related pathways are Axon guidance and Cell adhesion molecules (CAMs). An important paralog of this gene is NTN3.

UniProtKB/Swiss-Prot for NTNG1 Gene

  • Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Gene Wiki entry for NTNG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTNG1 Gene

Genomics for NTNG1 Gene

Regulatory Elements for NTNG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NTNG1 Gene

Chromosome:
1
Start:
107,139,918 bp from pter
End:
107,484,899 bp from pter
Size:
344,982 bases
Orientation:
Plus strand

Genomic View for NTNG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTNG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTNG1 Gene

Proteins for NTNG1 Gene

  • Protein details for NTNG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2I2-NTNG1_HUMAN
    Recommended name:
    Netrin-G1
    Protein Accession:
    Q9Y2I2
    Secondary Accessions:
    • Q5VU86
    • Q5VU87
    • Q5VU89
    • Q5VU90
    • Q5VU91
    • Q7Z2Y3
    • Q8N633

    Protein attributes for NTNG1 Gene

    Size:
    539 amino acids
    Molecular mass:
    60541 Da
    Quaternary structure:
    • Interacts with NGL1.
    SequenceCaution:
    • Sequence=BAA76820.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NTNG1 Gene

    Alternative splice isoforms for NTNG1 Gene

neXtProt entry for NTNG1 Gene

Proteomics data for NTNG1 Gene at MOPED

Post-translational modifications for NTNG1 Gene

Antibody Products

No data available for DME Specific Peptides for NTNG1 Gene

Domains & Families for NTNG1 Gene

Gene Families for NTNG1 Gene

Protein Domains for NTNG1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2I2

UniProtKB/Swiss-Prot:

NTNG1_HUMAN :
  • The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains
Domain:
  • The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains
  • Contains 3 laminin EGF-like domains.
  • Contains 1 laminin N-terminal domain.
genes like me logo Genes that share domains with NTNG1: view

Function for NTNG1 Gene

Molecular function for NTNG1 Gene

UniProtKB/Swiss-Prot Function:
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.

Gene Ontology (GO) - Molecular Function for NTNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14595443
genes like me logo Genes that share ontologies with NTNG1: view

Phenotypes for NTNG1 Gene

genes like me logo Genes that share phenotypes with NTNG1: view

Animal Model Products

miRNA for NTNG1 Gene

miRTarBase miRNAs that target NTNG1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NTNG1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NTNG1 Gene

Localization for NTNG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTNG1 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTNG1 Gene COMPARTMENTS Subcellular localization image for NTNG1 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for NTNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0046658 anchored component of plasma membrane ISS --
genes like me logo Genes that share ontologies with NTNG1: view

Pathways & Interactions for NTNG1 Gene

genes like me logo Genes that share pathways with NTNG1: view

Pathways by source for NTNG1 Gene

2 KEGG pathways for NTNG1 Gene

Gene Ontology (GO) - Biological Process for NTNG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007409 axonogenesis ISS --
genes like me logo Genes that share ontologies with NTNG1: view

No data available for SIGNOR curated interactions for NTNG1 Gene

Drugs & Compounds for NTNG1 Gene

No Compound Related Data Available

Transcripts for NTNG1 Gene

Unigene Clusters for NTNG1 Gene

Netrin G1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NTNG1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTNG1 Gene

No ASD Table

Relevant External Links for NTNG1 Gene

GeneLoc Exon Structure for
NTNG1
ECgene alternative splicing isoforms for
NTNG1

Expression for NTNG1 Gene

mRNA expression in normal human tissues for NTNG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTNG1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.8) and Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for NTNG1 Gene

This gene is overexpressed in Cerebrospinal fluid (37.4), Vitreous humor (22.3), and Fetal Brain (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NTNG1 Gene



SOURCE GeneReport for Unigene cluster for NTNG1 Gene Hs.732535

mRNA Expression by UniProt/SwissProt for NTNG1 Gene

Q9Y2I2-NTNG1_HUMAN
Tissue specificity: Highly expressed in the thalamus, with very low expression, if any, in other tissues.
genes like me logo Genes that share expression patterns with NTNG1: view

Protein tissue co-expression partners for NTNG1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for NTNG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTNG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NTNG1 35
  • 85.7 (n)
  • 87.53 (a)
MGC139448 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTNG1 35
  • 89.94 (n)
  • 91.53 (a)
NTNG1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntng1 35
  • 92.15 (n)
  • 96.47 (a)
Ntng1 16
Ntng1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NTNG1 35
  • 99.88 (n)
  • 100 (a)
NTNG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntng1 35
  • 92.76 (n)
  • 98.14 (a)
oppossum
(Monodelphis domestica)
Mammalia NTNG1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTNG1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves NTNG1 35
  • 83.82 (n)
  • 88.44 (a)
NTNG1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTNG1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntng1 35
  • 71.89 (n)
  • 73.39 (a)
zebrafish
(Danio rerio)
Actinopterygii ntng1 35
  • 70.12 (n)
  • 74.21 (a)
ntng1a 36
  • 71 (a)
OneToMany
vav3b 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta NetA 36
  • 19 (a)
ManyToMany
NetB 36
  • 18 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea unc-6 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for NTNG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTNG1 Gene

ENSEMBL:
Gene Tree for NTNG1 (if available)
TreeFam:
Gene Tree for NTNG1 (if available)

Paralogs for NTNG1 Gene

Paralogs for NTNG1 Gene

genes like me logo Genes that share paralogs with NTNG1: view

Variants for NTNG1 Gene

Sequence variations from dbSNP and Humsavar for NTNG1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs96501 -- 107,476,225(+) AGCAT(C/T)CTTTA intron-variant
rs479497 -- 107,415,373(+) TCATA(C/T)ATACA intron-variant
rs480392 -- 107,436,774(+) CCGGG(A/C)AATTC reference, synonymous-codon, intron-variant
rs482474 -- 107,415,730(+) GTTGA(C/T)GTATT intron-variant
rs483206 -- 107,437,057(+) ACCCG(G/T)CCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTNG1 Gene

Variant ID Type Subtype PubMed ID
dgv82e1 CNV Complex 17122850
nsv830982 CNV Gain 17160897
essv24194 CNV CNV 17122850
essv19382 CNV CNV 17122850
esv2678975 CNV Deletion 23128226
esv2674592 CNV Deletion 23128226
nsv508033 CNV Loss 20534489
nsv521184 CNV Loss 19592680
esv2676966 CNV Deletion 23128226
nsv830993 CNV Gain 17160897

Variation tolerance for NTNG1 Gene

Residual Variation Intolerance Score: 26.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTNG1 Gene

HapMap Linkage Disequilibrium report
NTNG1
Human Gene Mutation Database (HGMD)
NTNG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTNG1 Gene

Disorders for NTNG1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NTNG1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
partial fetal alcohol syndrome
rett syndrome
  • rett syndrome, preserved speech variant
schizophrenia
  • schizophrenia 12
- elite association
Search NTNG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NTNG1

Genetic Association Database (GAD)
NTNG1
Human Genome Epidemiology (HuGE) Navigator
NTNG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NTNG1
genes like me logo Genes that share disorders with NTNG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NTNG1 Gene

Publications for NTNG1 Gene

  1. Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. (PMID: 17507910) Eastwood S.L. … Harrison P.J. (Neuropsychopharmacology 2008) 23 67
  2. Human netrin-G1 isoforms show evidence of differential expression. (PMID: 15901489) Meerabux J.M. … Yoshikawa T. (Genomics 2005) 23 67
  3. A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia. (PMID: 15705354) Aoki-Suzuki M. … Yoshikawa T. (Biol. Psychiatry 2005) 23 67
  4. Disruption of Netrin G1 by a balanced chromosome translocation in a girl with Rett syndrome. (PMID: 15870826) Borg I. … Kalscheuer V.M. (Eur. J. Hum. Genet. 2005) 23 67
  5. Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. (PMID: 10964959) Nakashiba T. … Itohara S. (J. Neurosci. 2000) 2 67

Products for NTNG1 Gene

Sources for NTNG1 Gene

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