NTNG1 Gene

Aliases
for NTNG1 gene

Previous GC identifers: GC00U990862 GC09P128391 GC01P107038 GC01P107395 GC01P107484 GC01P105628

Summaries
for NTNG1 gene

Genomic Views
for NTNG1 gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_032977.9  

SwitchGear Promoter luciferase reporter plasmid: NTNG1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTNG1

NTNG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P107682:  view genomic region     (about GC identifiers)

Proteins
for NTNG1 gene

1 PDB 3D structure from and Proteopedia for NTNG1:

3ZYJ (3D)    

Explore the universe of human proteins at neXtProt for NTNG1: NX_Q9Y2I2

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: NTNG1 OriGene Custom Protein Services for NTNG1
	GenScript Custom Purified and Recombinant Proteins Services for NTNG1
	Novus Biologicals NTNG1 Protein Novus Biologicals NTNG1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for NTNG1 (Netrin-G1a)
	Browse OriGene Antibodies OriGene Custom Antibody Services for NTNG1
	GenScript Custom Superior Antibodies Services for NTNG1
	Novus Biologicals NTNG1 Antibodies
	Search for Antibodies for NTNG1 at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for NTNG1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NTNG1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for NTNG1 gene

ProtoNet protein and cluster: Q9Y2I2

Function
for NTNG1 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): NTNG1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTNG1
		8/43 QIAGEN miScript miRNA Assays for microRNAs that regulate NTNG1 (see all 43):
		hsa-miR-411* hsa-miR-579 hsa-miR-3194-5p hsa-miR-379* hsa-miR-30d hsa-miR-219-5p hsa-miR-632 hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: NTNG1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTNG1 (see all 7) OriGene shRNA RFP: NTNG1 OriGene siRNA: NTNG1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTNG1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for NTNG1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTNG1 (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTNG1 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): NTNG1 (NM_001113228)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTNG1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTNG1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NTNG1
		Search LifeMap BioReagents cell lines for NTNG1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTNG1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Ntng1)

Pathways & Interactions
for NTNG1 gene

	Super-pathway	contained gene-specific pathways
1	Axon guidance	Axon guidance 1.00

1         Kegg Pathway  (Kegg details for NTNG1)

Axon guidance

Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

Drugs & Compounds
for NTNG1 gene

Transcripts
for NTNG1 gene

Expression
for NTNG1 gene

NTNG1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

8 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells			Cartilage
	CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells			Cartilage
	CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells			Cartilage
	CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus Cells			Cartilage
	OvaryPrimary FollicleGranulosa Cells			Ovary
	OvaryPrimordial FolliclePre-Granulosa Cells			Ovary
	BoneMandibular Process			Bone
	CartilageLumbar Intervertebral Disc			Cartilage
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 3 LifeMap Cells
	Name			Category
	PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	PureStem™ progenitor F15 (Embryonic Progenitor Cell)
	N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTNG1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NTNG1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTNG1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTNG1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTNG1

Orthologs
for NTNG1 gene

Paralogs
for NTNG1 gene

Paralogs for NTNG1 gene

NTN4²  LAMA1²  NTN5²  LAMA3²  LAMA2²  LAMB2²  LAMC1²  LAMC2²  

LAMA5²  NTN3²  LAMB3²  LAMC3²  LAMA4²  NTN1²  USH2A²  LAMB4²  

LAMB1²  NTNG2²  

5 SIMAP similar genes for NTNG1 using alignment to 14 protein entries:     NTNG1_HUMAN (see all proteins):

NTNG2    VWDE    NELL1    NTN1    CRB1

NTNG1 for paralogs           About GeneDecksing

Genomic Variants
for NTNG1 gene

10/5761 NCBI SNPs in NTNG1 are shown (see all 5761)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1148723071,2	C,F,	--	107680699(+)	AAGCTG/CGTTTA	2	--	us2k1		1		WA	118
rs1403650921,2		--	107680775(+)	CCTTAC/TCACCT	3	--	us2k1		0	--	--	--	--
rs1812230681,2		--	107680792(+)	TGCTGA/GAGGAG	3	--	us2k1		0	--	--	--	--
rs1157502871,2		--	107681070(+)	TGATAC/TAGGAA	3	--	us2k1		1		WA	118
rs45422381,2	H	--	107681102(+)	CAAGAT/CTTTGA	3	--	us2k1		4		NS EA	420
rs1435521261,2		--	107681166(+)	GTATAC/TTCCAG	3	--	us2k1		0	--	--	--	--
rs1140898751,2		--	107681202(+)	GATTTA/GTTTTA	3	--	us2k1		1		NA	120
rs127508681,2	C,H	--	107681314(+)	TGAGAA/CCTGTC	3	--	us2k1		4		NS EA	420
rs1853663421,2		--	107681329(+)	TTTCAA/GGATCT	3	--	us2k1		0	--	--	--	--
rs127299091,2	H	--	107681364(+)	AGAAGG/CCCACT	3	--	us2k1		4		NS EA	418

HapMap Linkage Disequilibrium report for NTNG1 (107682629 - 107932629 bp, first 250kb of NTNG1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NTNG1
     3 CNVs: 2318 48074 3304
Human Gene Mutation Database (HGMD): NTNG1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NTNG1

DNA2.0 Custom Variant and Variant Library Synthesis for NTNG1

Disorders / Diseases
for NTNG1 gene

Publications
for NTNG1 gene

PubMed articles for NTNG1 gene, integrated from 9 sources (see all 28): (articles sorted by number of sources associating them with NTNG1)

Utopia: connect your pdf to the dynamic world of online information

1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
2. Case-control association study of human netrin G1 gene in Japanese schizophrenia. (PubMed id 15508520)^{1, 4} Fukasawa M....Yoshikawa T. (2004)
3. Fc receptor gamma subunit polymorphisms and systemic lupus erythematosus. (PubMed id 15494819)^{1, 4} Alansari A....Hajeer A.H. (2004)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
6. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
7. The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. (PubMed id 14595443)^{1, 2} Lin J.C.... Rosenthal A. (2003)
8. Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. (PubMed id 10964959)^{1, 3} Nakashiba T....Itohara S. (2000)
9. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10231032)^{1, 2} Nagase T.... Ohara O. (1999)
10. Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. (PubMed id 17507910)^{1, 9} Eastwood S.L. and Harrison P.J. (2008)

External Searches for NTNG1 gene

Genome Databases showing NTNG1 gene

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Specialized Databases showing NTNG1 gene

Products
for NTNG1 gene