NTN5 Gene
protein-coding GIFtS: 41
GCID: GC19M049164
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netrin 5
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Aliases
for NTN5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Netrin 51 2 | | Netrin-1-Like Protein2 3 | | Netrin-51 | | CNB25 |
Export aliases for NTN5 gene to outside databasesPrevious GC identifers: GC19M053857 GC19M045544 |
Summaries
for NTN5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NTN5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NTN5 gene promoter:
Bach1 AhR Elk-1 Spz1 Tal-1 p53 HTF E47 Max SRY
Other transcription factors
Search SABiosciences Chromatin IP Primers for NTN5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTN5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.33 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.33NTN5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M049164: view genomic region
(about GC identifiers)
Start:
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49,164,664 bp from pter |
End:
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49,176,264 bp from pter |
Size:
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11,601 bases |
Orientation:
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minus strand |
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Proteins
for NTN5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NET5_HUMAN, Q8WTR8 (See
protein sequence)Recommended Name: Netrin-5 precursor Size: 489 amino acids; 53174 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q8N4X9 Q8WU63Alternative splicing: 2 isoforms: Q8WTR8-1 Q8WTR8-2 Explore the universe of human proteins at neXtProt for NTN5: NX_Q8WTR8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WTR8
NTN5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_665806.1
ENSEMBL proteins: ENSP00000270235
Human Recombinant Protein Products for NTN5:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
NTN5 for ontologies About GeneDecksing
NTN5 Antibody Products:
Assay Products for NTN5: |
Protein
Domains /
Families
for NTN5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NTN5 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WTR8ProtoNet protein and cluster: Q8WTR8 1 Blocks protein family: IPB002049 Laminin-type EGF-like domain
UniProtKB/Swiss-Prot: NET5_HUMAN, Q8WTR8Similarity: Contains 3 laminin EGF-like domainsSimilarity: Contains 1 NTR domain |
Function
for NTN5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTN5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTN5 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): NTN5 (NM_175566) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NTN5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTN5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN5 |
|
Pathways & Interactions
for NTN5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NTN5
|
Drugs & Compounds
for NTN5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NTN5
Search CenterWatch for drugs/clinical trials and news about NTN5 / NET5
|
Transcripts
for NTN5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NTN5 gene: NM_145807.1 Unigene Cluster for NTN5: Netrin 5 Hs.326217 [show with all ESTs]Unigene Representative Sequence: BC0212101 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000270235(uc002pkb.3 uc002pkc.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTN5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTN5 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): NTN5 (NM_175566) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NTN5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTN5 |
Additional cDNA sequence: BC018654.2 BC018697.2 BC021210.2 BC033207.1 3 DOTS entries: DT.86857092 DT.97833296 DT.100021778 24/27 AceView cDNA sequences (see all 27): BC021210 BX283519 AW410201 BG826960 BE270224 AW409817 BG825494 BC033207 BE270309 BC018654 BC018697 NM_145807 AW411433 BF309789 BF307277 BE298601 BG826066 BF205793 BF307017 BG827394 AW410548 AW409705 BI004259 AW410200
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for NTN5 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for NTN5
|
Expression
for NTN5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NTN5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGCCGCGC
About this image
See NTN5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NTN5
SOURCE GeneReport for Unigene cluster: Hs.326217
SABiosciences Custom PCR Arrays for NTN5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTN5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NTN5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTN5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTN5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN5 |
Orthologs
for NTN5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NTN5 gene from 3/14 species (see all 14) About this table
ENSEMBL Gene Tree for NTN5 (if available)
TreeFam Gene Tree for NTN5 (if available) |
Paralogs
for NTN5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NTN5 gene
- NTN42 LAMA12 LAMA32 LAMA22 LAMB22 LAMC12 LAMC22 LAMA52
- NTN32 LAMB32 LAMC32 LAMA42 NTN12 NTNG12 USH2A2 LAMB42
- NTNG22 LAMB12
1 SIMAP similar gene for NTN5 using alignment to 2 protein entries: NET5_HUMAN (see all proteins):NTN1
NTN5 for paralogs About GeneDecksing
|
Genomic Variants
for NTN5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NTN5 (49164664 - 49176264 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NTN5
1 CNV: 32261 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NTN5 |
|
Disorders
/ Diseases
for NTN5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NTN5 for disorders About GeneDecksing
OMIM gene information: 607219
OMIM disorders: --
1  disease for NTN5: About MalaCardsneuronitis
Export disorders for NTN5 gene to outside databases
|
Publications
for NTN5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NTN5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NTN5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for NTN5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NTN5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NTN5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NTN5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NTN5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NTN5 gene:
Search GeneIP for patents involving NTN5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NTN5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NTN5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTN5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTN5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NTN5 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTN5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTN5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NTN5 | | OriGene Custom Protein Services for NTN5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NTN5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NTN5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTN5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTN5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTN5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTN5 |
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 |  |  |  | |
| | | | Search Tocris compounds for NTN5 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN5 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for NTN5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTN5 |
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