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NTN4 Gene

protein-coding   GIFtS: 59
GCID: GC12M095984

Netrin 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Netrin 41 2     PRO30912
beta-netrin1 2     netrin-42
Hepar-Derived Netrin-Like Protein2 3     Beta-netrin3
Netrin-41     

External Ids:    HGNC: 136581   Entrez Gene: 592772   Ensembl: ENSG000000745277   OMIM: 6104015   UniProtKB: Q9HB633   

Export aliases for NTN4 gene to outside databases

Previous GC identifers: GC12M095483 GC12M096415 GC12M094554 GC12M093118


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NTN4 Gene:
NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. (2000) (PubMed
11038171).(supplied by OMIM, Mar 2008)

GeneCards Summary for NTN4 Gene:
NTN4 (netrin 4) is a protein-coding gene. Diseases associated with NTN4 include endotheliitis, and colorectal cancer. GO annotations related to this gene include laminin-1 binding. An important paralog of this gene is NTN1.

UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63
Function: May play an important role in neural, kidney and vascular development. Promotes neurite elongation from
olfactory bulb explants




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the NTN4 gene promoter:
         Sox5   AML1a   Pax-2   Pax-2a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   AP-2gamma   POU3F2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTN4 promoter sequence
   Search Chromatin IP Primers for NTN4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q22

NTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTN4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M095984:  view genomic region     (about GC identifiers)

Start:
96,051,583 bp from pter      End:
96,184,930 bp from pter
Size:
133,348 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63 (See protein sequence)
Recommended Name: Netrin-4 precursor  
Size: 628 amino acids; 70071 Da
Subunit: May form a homodimer
Secondary accessions: B2RNC2 Q658K9 Q7L3F1 Q7L9D6 Q7Z5B6 Q9BZP1 Q9NT44 Q9P133
Alternative splicing: 3 isoforms:  Q9HB63-1   Q9HB63-2   Q9HB63-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NTN4: NX_Q9HB63

Explore proteomics data for NTN4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn56, Asn163, Asn353, Asn483

  • See NTN4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067052.2  
    ENSEMBL proteins: 
     ENSP00000340998   ENSP00000339436   ENSP00000444432   ENSP00000447292   ENSP00000447594  
    Reactome Protein details: Q9HB63

    NTN4 Human Recombinant Protein Products:

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    Novus Biologicals NTN4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    NTN4 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for NTN4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    NTN: Netrins

    5 InterPro protein domains:
     IPR008993 TIMP-like_OB-fold
     IPR008211 Laminin_N
     IPR001134 Netrin_domain
     IPR002049 EGF_laminin
     IPR018933 Netrin_module_non-TIMP

    Graphical View of Domain Structure for InterPro Entry Q9HB63

    ProtoNet protein and cluster: Q9HB63

    1 Blocks protein domain: IPB001134 Netrin

    UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63
    Similarity: Contains 3 laminin EGF-like domains
    Similarity: Contains 1 laminin N-terminal domain
    Similarity: Contains 1 NTR domain


    NTN4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NET4_HUMAN, Q9HB63
    Function: May play an important role in neural, kidney and vascular development. Promotes neurite elongation from
    olfactory bulb explants

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0043237laminin-1 binding IEA--
         
    NTN4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ntn4):
     cardiovascular system  cellular  nervous system  vision/eye 

    NTN4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ntn4tm1Wjbr for NTN4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NTN4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTN4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTN4

    miRNA
    Products:
        
    miRTarBase miRNAs that target NTN4:
    hsa-mir-335-5p (MIRT017325)

    Block miRNA regulation of human, mouse, rat NTN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NTN4 (see all 47):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-449a hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidNTN4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NTN4

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NTN4 (NM_021229)
    Sino Biological Human cDNA Clone for NTN4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTN4

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for NTN4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NET4_HUMAN, Q9HB63: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--
    GO:0005886plasma membrane TAS--

    NTN4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NTN4 About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    2Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.35
    3Degradation of the extracellular matrix
    Extracellular matrix organization0.34
    4Netrin-1 signaling
    Netrin-1 signaling
    5Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for NTN4
        Netrin-1 signaling
    Non-integrin membrane-ECM interactions


    1 Kegg Pathway  (Kegg details for NTN4):
        Axon guidance


    NTN4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NTN4
    Interactions:

        Search GeneGlobe Interaction Network for NTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for NTN4 (Q9HB632, 3 ENSP000003409984) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLSCR1O151622, 3, ENSP000003454944MINT-66345 I2D: score=5 STRING: ENSP00000345494
    ADAMTSL4Q6UY143, ENSP000002716434I2D: score=5 STRING: ENSP00000271643
    KRTAP5-9P263713I2D: score=1 
    MMS19ENSP000003598184STRING: ENSP00000359818
    RGS20ENSP000002973134STRING: ENSP00000297313
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007411axon guidance TAS--
    GO:0016322neuron remodeling IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0060668regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling IEA--

    NTN4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NTN4 (NET4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NTN4 gene: 
    NM_021229.3  

    Unigene Cluster for NTN4:

    Netrin 4
    Hs.201034  [show with all ESTs]
    Unigene Representative Sequence: NM_021229
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343702(uc001tei.3 uc009ztf.3) ENST00000344911(uc009ztg.3)
    ENST00000538383 ENST00000553059 ENST00000550074 ENST00000552603 ENST00000547980

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NTN4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NTN4 (see all 47):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-449a hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidNTN4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NTN4
    Predesigned siRNA for gene silencing in human, mouse, rat NTN4
    Clone
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    OriGene ORF clones in mouse, rat for NTN4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: NTN4 (NM_021229)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTN4
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for NTN4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NTN4
      QuantiTect SYBR Green Assays in human, mouse, rat NTN4
      QuantiFast Probe-based Assays in human, mouse, rat NTN4

    Additional mRNA sequence: 

    AF119916.3 AF278532.1 AF297711.1 AK024691.1 AK026833.1 AK226070.1 AK290591.1 AK315796.1 
    AL137540.1 AL833767.1 AY330211.1 BC013591.1 BC136798.1 BC136799.1 Z50158.1 

    9 DOTS entries:

    DT.415047  DT.95277496  DT.99945024  DT.121211282  DT.440466  DT.91719831  DT.40120268  DT.91868157 
    DT.40267537 

    Selected AceView cDNA sequences (see all 143):

    BU620432 D62343 CB305456 BM982445 AL137540 AA252946 BQ774632 AL833767 
    AI432592 R76614 AA342502 CD630787 BC013591 AA298498 BF112106 CD676656 
    AI702544 AU280152 AA513296 AF119916 BU683251 AI493056 AI927505 AI207710 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NTN4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:              -                                                                     
    SP2:              -                                               -                     
    SP3:                                                                                    


    ECgene alternative splicing isoforms for NTN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NTN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACACAGTGC
    NTN4 Expression
    About this image


    NTN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Paraxial Mesoderm (Gastrulation Derivatives)
             PureStem E15, Meso-prx/latp Progenitor
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    NTN4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NTN4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.201034

    UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63
    Tissue specificity: Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NTN4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntn41 , 5 netrin 41, 5 85.33(n)1
    89.95(a)1
      10 (48.59 cM)5
    577641  NM_021320.31  NP_067295.21 
     936406815 
    chicken
    (Gallus gallus)
    Aves NTN41 netrin 4 72.39(n)
    75.12(a)
      417914  XM_004937648.1  XP_004937705.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTN46
    netrin 4
    74(a)
    1 ↔ 1
    5(30687363-30728639)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.324782 Xenopus laevis transcribed sequence with weak similarity more 70.62(n)    BJ632828.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntn41 netrin 4 59.12(n)
    56.34(a)
      561440  NM_001037686.1  NP_001032775.1 


    ENSEMBL Gene Tree for NTN4 (if available)
    TreeFam Gene Tree for NTN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NTN4 gene
    NTN12  NTNG12  NTN32  LAMB32  NTN52  NTNG22  
    5 SIMAP similar genes for NTN4 using alignment to 3 protein entries:     NET4_HUMAN (see all proteins):
    LAMB3    LAMB4    unknown    LAMB1    LAMB2

    NTN4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NTN4 (see all 2522)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352451871,2
    C--95963198(+) AAAAAA/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1161396441,2
    C,F--96068345(+) TTTTGT/CTATTT 1 -- int11Minor allele frequency- C:0.03WA 118
    rs111081861,2
    C,F--96068352(+) ATTTAG/CGAAGT 1 -- int11Minor allele frequency- C:0.21EA 120
    rs764487151,2
    C,F--96068367(+) TTTTAC/TATCTG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1932535431,2
    --96068438(+) GAAAGC/TTGTTT 1 -- int10--------
    rs8773121,2
    F--96068456(-) TCCCAT/CAAGTT 1 -- int12Minor allele frequency- C:0.01MN WA 302
    rs1851453811,2
    --96068507(+) TTGTTC/GAAAAA 1 -- int10--------
    rs1500319421,2
    --96068568(+) TTCCTC/TAATCT 1 -- int10--------
    rs1890931541,2
    --96068576(+) TCTGGC/TGTTCA 1 -- int10--------
    rs111081871,2
    C,F--96068652(+) TCTGCA/CGTCAT 1 -- int11Minor allele frequency- C:0.22EA 120

    HapMap Linkage Disequilibrium report for NTN4 (96051583 - 96184930 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NTN4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833CNV Insertion18451855
    nsv526022CNV Loss19592680
    nsv455692CNV Gain19166990
    nsv7234OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NTN4
    DNA2.0 Custom Variant and Variant Library Synthesis for NTN4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610401    OMIM disorders: --

    5 diseases for NTN4:    
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    endotheliitis    colorectal cancer    breast cancer    prostatitis
    neuronitis


    NTN4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NTN4
    Human Genome Epidemiology (HuGE) Navigator: NTN4 (3 documents)

    Export disorders for NTN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NTN4 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with NTN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin. Identification, expression, and functional characterization. (PubMed id 11038171)1, 2, 3, 9 Koch M.... Burgeson R.E. (J. Cell Biol. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. (PubMed id 17174565)1, 9 Qin S....Zhang C. (Mol. Cell. Neurosci. 2007)
    5. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. (PubMed id 18719102)1, 9 Lejmi E....PlouAt J. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain. (PubMed id 15519678)1, 9 Zhang C....He F. (Brain Res. Mol. Brain Res. 2004)
    7. Netrin-4 regulates angiogenic responses and tumor cell growth. (PubMed id 19094984)1, 9 Nacht M....Jiang Y. (Exp. Cell Res. 2009)
    8. Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. (PubMed id 17545519)1, 9 Esseghir S....Isacke C.M. (Clin. Cancer Res. 2007)
    9. A genome-wide association study in Koreans identifies susceptibility loci for allergic nickel dermatitis. (PubMed id 23921680)1 Kim D.S....Lee M.G. (Int. Arch. Allergy Immunol. 2013)
    10. miR-196a targets netrin 4 and regulates cell proliferation and migration of cervical cancer cells. (PubMed id 24120501)1 Zhang J....Lu Q. (Biochem. Biophys. Res. Commun. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 59277 HGNC: 13658 AceView: NTN4 Ensembl:ENSG00000074527 euGenes: HUgn59277
    ECgene: NTN4 Kegg: 59277 H-InvDB: NTN4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NTN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NTN4 gene:
    Search GeneIP for patents involving NTN4

    Licensable Technologies for NTN4 gene:
     Tufts University:  Beta Netrin and uses thereof
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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