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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTN4 Gene

protein-coding   GIFtS: 59
GCID: GC12M095984

Netrin 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Netrin 41 2     PRO30912
beta-netrin1 2     netrin-42
Hepar-Derived Netrin-Like Protein2 3     Beta-netrin3
Netrin-41     

External Ids:    HGNC: 136581   Entrez Gene: 592772   Ensembl: ENSG000000745277   OMIM: 6104015   UniProtKB: Q9HB633   

Export aliases for NTN4 gene to outside databases

Previous GC identifers: GC12M095483 GC12M096415 GC12M094554 GC12M093118


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTN4 Gene:
NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. (2000) (PubMed
11038171).(supplied by OMIM, Mar 2008)

GeneCards Summary for NTN4 Gene: 
NTN4 (netrin 4) is a protein-coding gene. Diseases associated with NTN4 include glioblastoma, and colorectal cancer, and among its related super-pathways are Axon guidance and Syndecan interactions. GO annotations related to this gene include laminin-1 binding. An important paralog of this gene is LAMC1.

UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63
Function: May play an important role in neural, kidney and vascular development. Promotes neurite elongation from
olfactory bulb explants




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NTN4 gene promoter:
         Sox5   AML1a   Pax-2   Pax-2a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   AP-2gamma   POU3F2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NTN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q22

NTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTN4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M095984:  view genomic region     (about GC identifiers)

Start:
96,051,583 bp from pter      End:
96,184,930 bp from pter
Size:
133,348 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63 (See protein sequence)
Recommended Name: Netrin-4 precursor  
Size: 628 amino acids; 70071 Da
Subunit: May form a homodimer
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component
Secondary accessions: B2RNC2 Q658K9 Q7L3F1 Q7L9D6 Q7Z5B6 Q9BZP1 Q9NT44 Q9P133
Alternative splicing: 3 isoforms:  Q9HB63-1   Q9HB63-2   Q9HB63-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NTN4: NX_Q9HB63

Explore proteomics data for NTN4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9HB63

  • NTN4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NTN4 Protein Expression
    REFSEQ proteins: NP_067052.2  
    ENSEMBL proteins: 
     ENSP00000340998   ENSP00000339436   ENSP00000444432   ENSP00000447292   ENSP00000447594  
    Reactome Protein details: Q9HB63
    Human Recombinant Protein Products for NTN4: 
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    Enzo Life Sciences proteins for NTN4
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for NTN4
    OriGene Custom MassSpec 
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    Novus Biologicals NTN4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--
    GO:0005886plasma membrane TAS--

    NTN4 for ontologies           About GeneDecksing



    NTN4 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NTN: Netrins

    5 InterPro protein domains:
     IPR008993 TIMP-like_OB-fold
     IPR008211 Laminin_N
     IPR001134 Netrin_domain
     IPR002049 EGF_laminin
     IPR018933 Netrin_module_non-TIMP

    Graphical View of Domain Structure for InterPro Entry Q9HB63

    ProtoNet protein and cluster: Q9HB63

    1 Blocks protein domain: IPB001134 Netrin

    UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63
    Similarity: Contains 3 laminin EGF-like domains
    Similarity: Contains 1 laminin N-terminal domain
    Similarity: Contains 1 NTR domain


    NTN4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NET4_HUMAN, Q9HB63
    Function: May play an important role in neural, kidney and vascular development. Promotes neurite elongation from
    olfactory bulb explants

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0043237laminin-1 binding IEA--
         
    NTN4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ntn4):
     cardiovascular system  cellular  nervous system  vision/eye 

    NTN4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ntn4tm1Wjbr for NTN4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for NTN4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NTN4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTN4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTN4 

    miRNA
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    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate NTN4 (see all 47):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-449a hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidNTN4 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NTN4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    2Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.44
    3Collagen biosynthesis and modifying enzymes
    Extracellular matrix organization0.39
    4Netrin-1 signaling
    Netrin-1 signaling0.33
    5Axon guidance
    Axon guidance

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5        Reactome Pathways for NTN4
        Developmental Biology
    Extracellular matrix organization
    Netrin-1 signaling
    Non-integrin membrane-ECM interactions
    Axon guidance


    1         Kegg Pathway  (Kegg details for NTN4):
        Axon guidance


    NTN4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for NTN4 (Q9HB632, 3 ENSP000003409984) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLSCR1O151622, 3, ENSP000003454944MINT-66345 I2D: score=5 STRING: ENSP00000345494
    ADAMTSL4Q6UY143, ENSP000002716434I2D: score=5 STRING: ENSP00000271643
    KRTAP5-9P263713I2D: score=1 
    MMS19ENSP000003598184STRING: ENSP00000359818
    RGS20ENSP000002973134STRING: ENSP00000297313
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007411axon guidance TAS--
    GO:0016322neuron remodeling IEA--
    GO:0030198extracellular matrix organization TAS--
    GO:0060668regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling IEA--

    NTN4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NTN4 (NET4)

    Search CenterWatch for drugs/clinical trials and news about NTN4 / NET4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NTN4 gene: 
    NM_021229.3  

    Unigene Cluster for NTN4:

    Netrin 4
    Hs.201034  [show with all ESTs]
    Unigene Representative Sequence: NM_021229
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343702(uc001tei.3 uc009ztf.3) ENST00000344911(uc009ztg.3)
    ENST00000538383 ENST00000553059 ENST00000550074 ENST00000552603 ENST00000547980

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTN4
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate NTN4 (see all 47):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-449a hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidNTN4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NTN4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTN4
    Clone
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    OriGene ORF clones in mouse, rat for NTN4
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTN4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTN4
    Sirion Biotech Customized lentivirus for stable overexpression of NTN4 
                         Customized lentivirus expression plasmids for stable overexpression of NTN4 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTN4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTN4

    Additional mRNA sequence: 

    AF119916.3 AF278532.1 AF297711.1 AK024691.1 AK026833.1 AK226070.1 AK290591.1 AK315796.1 
    AL137540.1 AL833767.1 AY330211.1 BC013591.1 BC136798.1 BC136799.1 Z50158.1 

    9 DOTS entries:

    DT.415047  DT.95277496  DT.99945024  DT.121211282  DT.440466  DT.91719831  DT.40120268  DT.91868157 
    DT.40267537 

    24/143 AceView cDNA sequences (see all 143):

    CB305456 R76614 BC013591 AL833767 CD676656 AI432592 AI702544 BF112106 
    BM982445 AI493056 AA513296 AI207710 AF119916 CD630787 AI927505 BU620432 
    AA342502 D62343 AU280152 AA252946 BU683251 AA298498 AL137540 BQ774632 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NTN4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:              -                                                                     
    SP2:              -                                               -                     
    SP3:                                                                                    


    ECgene alternative splicing isoforms for NTN4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTN4 expression in normal human tissues (normalized intensities)      NTN4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACACAGTGC
    NTN4 Expression
    About this image


    NTN4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 6 entries
             PureStem progenitor F15
     
     Endothelium (Cardiovascular System)    fully expand to see all 4 entries
             Human umbilical vein endothelial cells (HUVEC)
             CD31, CD144 positive cells ( Two-step protocol for endothelial differentiation by...
             Human Umbilical Vein Endothelial Cells (HUVEC) (ScienceCell)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Wharton's jelly-derived stem cells
             Human Umbilical Vein Endothelial Cells (HUVEC) (ScienceCell)   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Ectoderm (Gastrulation Derivatives)
             PureStem ES-210, Ecto-ntu Progenitor

    See NTN4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTN4

    SOURCE GeneReport for Unigene cluster: Hs.201034

    UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63
    Tissue specificity: Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen

        SABiosciences Custom PCR Arrays for NTN4
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTN4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NTN4 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntn41 , 5 netrin 41, 5 85.33(n)1
    89.95(a)1
      10 (48.59 cM)5
    577641  NM_021320.31  NP_067295.21 
     936406815 
    chicken
    (Gallus gallus)
    Aves NTN41 netrin 4 72.55(n)
    75.41(a)
      417914  XM_416155.2  XP_416155.2 
    lizard
    (Anolis carolinensis)
    Reptilia NTN46
    Uncharacterized protein
    74(a)
    1 ↔ 1
    5(30687363-30728639)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.324782 Xenopus laevis transcribed sequence with weak similarity more 70.62(n)    BJ632828.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntn41 netrin 4 59.16(n)
    56.41(a)
      561440  NM_001037686.1  NP_001032775.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta wb6
    wing blister
    5(a)
    1 → many
    2L(14263027-14328262)


    ENSEMBL Gene Tree for NTN4 (if available)
    TreeFam Gene Tree for NTN4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTN4 gene
    LAMC12  LAMC22  NTN32  LAMB32  NTN52  LAMC32  NTN12  NTNG12  
    USH2A2  NTNG22  LAMB42  LAMB22  LAMB12  
    5 SIMAP similar genes for NTN4 using alignment to 3 protein entries:     NET4_HUMAN (see all proteins):
    LAMB3    LAMB4    unknown    LAMB1    LAMB2

    NTN4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2522 SNPs in NTN4 are shown (see all 2522)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs352451871,2
    C--95963198(+) AAAAAA/-TTTTT 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1161396441,2
    C,F--96068345(+) TTTTGT/CTATTT 1 -- int11Minor allele frequency- C:0.03WA 118
    rs111081861,2
    C,F--96068352(+) ATTTAG/CGAAGT 1 -- int11Minor allele frequency- C:0.21EA 120
    rs764487151,2
    C,F--96068367(+) TTTTAC/TATCTG 1 -- int11Minor allele frequency- T:0.01NA 120
    rs1932535431,2
    --96068438(+) GAAAGC/TTGTTT 1 -- int10--------
    rs8773121,2
    F--96068456(-) TCCCAT/CAAGTT 1 -- int12Minor allele frequency- C:0.01MN WA 302
    rs1851453811,2
    --96068507(+) TTGTTC/GAAAAA 1 -- int10--------
    rs1500319421,2
    --96068568(+) TTCCTC/TAATCT 1 -- int10--------
    rs1890931541,2
    --96068576(+) TCTGGC/TGTTCA 1 -- int10--------
    rs111081871,2
    C,F--96068652(+) TCTGCA/CGTCAT 1 -- int11Minor allele frequency- C:0.22EA 120

    HapMap Linkage Disequilibrium report for NTN4 (96051583 - 96184930 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NTN4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833CNV Insertion18451855
    nsv526022CNV Loss19592680
    nsv455692CNV Gain19166990
    nsv7234OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610401    OMIM disorders: --

    6 diseases for NTN4:    About MalaCards
    glioblastoma    colorectal cancer    endotheliitis    breast cancer
    prostatitis    neuronitis


    NTN4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NTN4
    Human Genome Epidemiology (HuGE) Navigator: NTN4 (3 documents)

    Export disorders for NTN4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTN4 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with NTN4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin. Identification, expression, and functional characterization. (PubMed id 11038171)1, 2, 3, 9 Koch M.... Burgeson R.E. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. (PubMed id 17174565)1, 9 Qin S....Zhang C. (2007)
    5. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. (PubMed id 18719102)1, 9 Lejmi E....Plouet J. (2008)
    6. Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain. (PubMed id 15519678)1, 9 Zhang C....He F. (2004)
    7. Netrin-4 regulates angiogenic responses and tumor cell growth. (PubMed id 19094984)1, 9 Nacht M....Jiang Y. (2009)
    8. Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. (PubMed id 17545519)1, 9 Esseghir S....Isacke C.M. (2007)
    9. Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (2013)
    10. Genome-wide association studies identify four ER negat ive-specific breast cancer risk loci. (PubMed id 23535733)1 Garcia-Closas M....Kraft P. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59277 HGNC: 13658 AceView: NTN4 Ensembl:ENSG00000074527 euGenes: HUgn59277
    ECgene: NTN4 Kegg: 59277 H-InvDB: NTN4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTN4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NTN4 gene:
    Search GeneIP for patents involving NTN4

    Licensable Technologies for NTN4 gene:
     Tufts University:  Beta Netrin and uses thereof
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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