Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NTN4 Gene

Aliases for NTN4 Gene

  • Netrin 4 2 3 5
  • Beta-Netrin 2 3 4
  • Hepar-Derived Netrin-Like Protein 3 4
  • Netrin-4 2
  • PRO3091 3

External Ids for NTN4 Gene

Previous GeneCards Identifiers for NTN4 Gene

  • GC12M095483
  • GC12M096415
  • GC12M095984
  • GC12M094554
  • GC12M093118

Summaries for NTN4 Gene

Entrez Gene Summary for NTN4 Gene

  • NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. (2000) [PubMed 11038171].[supplied by OMIM, Mar 2008]

GeneCards Summary for NTN4 Gene

NTN4 (Netrin 4) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Developmental Biology. GO annotations related to this gene include laminin-1 binding. An important paralog of this gene is LAMC2.

UniProtKB/Swiss-Prot for NTN4 Gene

  • May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTN4 Gene

Genomics for NTN4 Gene

Regulatory Elements for NTN4 Gene

Promoters for NTN4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NTN4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NTN4 Gene

Chromosome:
12
Start:
95,657,807 bp from pter
End:
95,791,152 bp from pter
Size:
133,346 bases
Orientation:
Minus strand

Genomic View for NTN4 Gene

Genes around NTN4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTN4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTN4 Gene

Proteins for NTN4 Gene

  • Protein details for NTN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB63-NET4_HUMAN
    Recommended name:
    Netrin-4
    Protein Accession:
    Q9HB63
    Secondary Accessions:
    • B2RNC2
    • Q658K9
    • Q7L3F1
    • Q7L9D6
    • Q7Z5B6
    • Q9BZP1
    • Q9NT44
    • Q9P133

    Protein attributes for NTN4 Gene

    Size:
    628 amino acids
    Molecular mass:
    70071 Da
    Quaternary structure:
    • May form a homodimer.

    Alternative splice isoforms for NTN4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTN4 Gene

Proteomics data for NTN4 Gene at MOPED

Post-translational modifications for NTN4 Gene

  • Glycosylation at Asn 56, Asn 163, Asn 353, and Asn 483
  • Modification sites at PhosphoSitePlus

Other Protein References for NTN4 Gene

Antibody Products

No data available for DME Specific Peptides for NTN4 Gene

Domains & Families for NTN4 Gene

Gene Families for NTN4 Gene

Protein Domains for NTN4 Gene

Suggested Antigen Peptide Sequences for NTN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HB63

UniProtKB/Swiss-Prot:

NET4_HUMAN :
  • Contains 3 laminin EGF-like domains.
Domain:
  • Contains 3 laminin EGF-like domains.
  • Contains 1 laminin N-terminal domain.
  • Contains 1 NTR domain.
genes like me logo Genes that share domains with NTN4: view

Function for NTN4 Gene

Molecular function for NTN4 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.

Gene Ontology (GO) - Molecular Function for NTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043237 laminin-1 binding IEA --
genes like me logo Genes that share ontologies with NTN4: view
genes like me logo Genes that share phenotypes with NTN4: view

Animal Models for NTN4 Gene

MGI Knock Outs for NTN4:

Animal Model Products

  • Taconic Biosciences Mouse Models for NTN4

miRNA for NTN4 Gene

miRTarBase miRNAs that target NTN4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NTN4 Gene

Localization for NTN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTN4 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTN4 Gene COMPARTMENTS Subcellular localization image for NTN4 gene
Compartment Confidence
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for NTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
genes like me logo Genes that share ontologies with NTN4: view

Pathways & Interactions for NTN4 Gene

genes like me logo Genes that share pathways with NTN4: view

Pathways by source for NTN4 Gene

SIGNOR curated interactions for NTN4 Gene

Activates:

Gene Ontology (GO) - Biological Process for NTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016322 neuron remodeling IEA --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with NTN4: view

Drugs & Compounds for NTN4 Gene

No Compound Related Data Available

Transcripts for NTN4 Gene

Unigene Clusters for NTN4 Gene

Netrin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTN4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -
SP3:

Relevant External Links for NTN4 Gene

GeneLoc Exon Structure for
NTN4
ECgene alternative splicing isoforms for
NTN4

Expression for NTN4 Gene

mRNA expression in normal human tissues for NTN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTN4 Gene

This gene is overexpressed in Spleen (x5.1).

Protein differential expression in normal tissues from HIPED for NTN4 Gene

This gene is overexpressed in Lung (26.6), Testis (9.8), Gallbladder (8.9), and Islet of Langerhans (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NTN4 Gene



SOURCE GeneReport for Unigene cluster for NTN4 Gene Hs.201034

mRNA Expression by UniProt/SwissProt for NTN4 Gene

Q9HB63-NET4_HUMAN
Tissue specificity: Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen.
genes like me logo Genes that share expression patterns with NTN4: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for NTN4 Gene

Orthologs for NTN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTN4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTN4 35
  • 99.49 (n)
  • 99.32 (a)
NTN4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NTN4 36
  • 91 (a)
OneToOne
NTN4 35
  • 90.32 (n)
  • 91.39 (a)
dog
(Canis familiaris)
Mammalia NTN4 35
  • 91.4 (n)
  • 92.2 (a)
NTN4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntn4 16
Ntn4 36
  • 90 (a)
OneToOne
Ntn4 35
  • 85.33 (n)
  • 89.95 (a)
oppossum
(Monodelphis domestica)
Mammalia NTN4 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTN4 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntn4 35
  • 85.7 (n)
  • 89.79 (a)
chicken
(Gallus gallus)
Aves NTN4 36
  • 74 (a)
OneToOne
NTN4 35
  • 72.39 (n)
  • 75.12 (a)
lizard
(Anolis carolinensis)
Reptilia NTN4 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32478 35
zebrafish
(Danio rerio)
Actinopterygii ntn4 36
  • 48 (a)
OneToOne
ntn4 35
  • 59.12 (n)
  • 56.34 (a)
Species with no ortholog for NTN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTN4 Gene

ENSEMBL:
Gene Tree for NTN4 (if available)
TreeFam:
Gene Tree for NTN4 (if available)

Paralogs for NTN4 Gene

Paralogs for NTN4 Gene

(5) SIMAP similar genes for NTN4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NTN4: view

Variants for NTN4 Gene

Sequence variations from dbSNP and Humsavar for NTN4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_023548 -
rs728661 -- 95,677,544(+) AATCC(C/T)AAGCA intron-variant
rs2468358 -- 95,705,700(-) GTTAC(A/G)GAGTG intron-variant
rs2468359 -- 95,705,673(-) AGAGG(A/G)GCAGT intron-variant
rs2468360 -- 95,701,888(-) AATAC(G/T)TACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTN4 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv455692 CNV Gain 19166990
nsv526022 CNV Loss 19592680
nsv833 CNV Insertion 18451855

Variation tolerance for NTN4 Gene

Residual Variation Intolerance Score: 41.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.39; 63.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTN4 Gene

HapMap Linkage Disequilibrium report
NTN4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTN4 Gene

Disorders for NTN4 Gene

Relevant External Links for NTN4

Genetic Association Database (GAD)
NTN4
Human Genome Epidemiology (HuGE) Navigator
NTN4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NTN4

No disorders were found for NTN4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NTN4 Gene

Publications for NTN4 Gene

  1. A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin. Identification, expression, and functional characterization. (PMID: 11038171) Koch M. … Burgeson R.E. (J. Cell Biol. 2000) 2 3 4 23 67
  2. Netrin-4 regulates angiogenic responses and tumor cell growth. (PMID: 19094984) Nacht M. … Jiang Y. (Exp. Cell Res. 2009) 3 23
  3. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. (PMID: 18719102) Lejmi E. … PlouAt J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  4. Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. (PMID: 17174565) Qin S. … Zhang C. (Mol. Cell. Neurosci. 2007) 3 23
  5. Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. (PMID: 17545519) Esseghir S. … Isacke C.M. (Clin. Cancer Res. 2007) 3 23

Products for NTN4 Gene

Sources for NTN4 Gene

Back to Top

Content