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Aliases for NTN4 Gene

Aliases for NTN4 Gene

  • Netrin 4 2 3
  • Beta-Netrin 2 3 4
  • Hepar-Derived Netrin-Like Protein 3 4
  • Netrin-4 2 3
  • PRO3091 3

External Ids for NTN4 Gene

Previous GeneCards Identifiers for NTN4 Gene

  • GC12M095483
  • GC12M096415
  • GC12M095984
  • GC12M094554
  • GC12M093118

Summaries for NTN4 Gene

Entrez Gene Summary for NTN4 Gene

  • NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. (2000) [PubMed 11038171].[supplied by OMIM, Mar 2008]

GeneCards Summary for NTN4 Gene

NTN4 (Netrin 4) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Degradation of the extracellular matrix. GO annotations related to this gene include laminin-1 binding. An important paralog of this gene is NTN3.

UniProtKB/Swiss-Prot for NTN4 Gene

  • May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTN4 Gene

Genomics for NTN4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NTN4 Gene

95,657,807 bp from pter
95,791,152 bp from pter
133,346 bases
Minus strand

Genomic View for NTN4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTN4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTN4 Gene

Proteins for NTN4 Gene

  • Protein details for NTN4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2RNC2
    • Q658K9
    • Q7L3F1
    • Q7L9D6
    • Q7Z5B6
    • Q9BZP1
    • Q9NT44
    • Q9P133

    Protein attributes for NTN4 Gene

    628 amino acids
    Molecular mass:
    70071 Da
    Quaternary structure:
    • May form a homodimer

    Alternative splice isoforms for NTN4 Gene


neXtProt entry for NTN4 Gene

Proteomics data for NTN4 Gene at MOPED

Post-translational modifications for NTN4 Gene

  • Glycosylation at Asn56, Asn163, Asn353, and Asn483
  • Modification sites at PhosphoSitePlus

Other Protein References for NTN4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NTN4 Gene

Domains for NTN4 Gene

Gene Families for NTN4 Gene


Protein Domains for NTN4 Gene

Suggested Antigen Peptide Sequences for NTN4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9HB63
  • Contains 3 laminin EGF-like domains.
  • Contains 1 laminin N-terminal domain.
  • Contains 1 NTR domain.
genes like me logo Genes that share domains with NTN4: view

Function for NTN4 Gene

Molecular function for NTN4 Gene

UniProtKB/Swiss-Prot Function: May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants.

Gene Ontology (GO) - Molecular Function for NTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0043237 laminin-1 binding IEA --
genes like me logo Genes that share ontologies with NTN4: view
genes like me logo Genes that share phenotypes with NTN4: view

Animal Models for NTN4 Gene

MGI Knock Outs for NTN4:

Animal Model Products

miRNA for NTN4 Gene

miRTarBase miRNAs that target NTN4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NTN4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NTN4 Gene

Localization for NTN4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTN4 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Subcellular locations from

Jensen Localization Image for NTN4 Gene COMPARTMENTS Subcellular localization image for NTN4 gene
Compartment Confidence
extracellular 5
plasma membrane 4

Gene Ontology (GO) - Cellular Components for NTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005604 basement membrane IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with NTN4: view

Pathways for NTN4 Gene

genes like me logo Genes that share pathways with NTN4: view

Pathways by source for NTN4 Gene

Gene Ontology (GO) - Biological Process for NTN4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance TAS --
GO:0016322 neuron remodeling IEA --
GO:0030198 extracellular matrix organization TAS --
GO:0060668 regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling IEA --
genes like me logo Genes that share ontologies with NTN4: view

Transcripts for NTN4 Gene

Unigene Clusters for NTN4 Gene

Netrin 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NTN4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NTN4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTN4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: -
SP2: - -

Relevant External Links for NTN4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NTN4 Gene

mRNA expression in normal human tissues for NTN4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTN4 Gene

This gene is overexpressed in Spleen (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NTN4 Gene

SOURCE GeneReport for Unigene cluster for NTN4 Gene Hs.201034

mRNA Expression by UniProt/SwissProt for NTN4 Gene

Tissue specificity: Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen.
genes like me logo Genes that share expressions with NTN4: view

In Situ Assay Products

Orthologs for NTN4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTN4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NTN4 35
  • 99.49 (n)
  • 99.32 (a)
NTN4 36
  • 99 (a)
(Bos Taurus)
Mammalia NTN4 35
  • 90.32 (n)
  • 91.39 (a)
NTN4 36
  • 91 (a)
(Canis familiaris)
Mammalia NTN4 35
  • 91.4 (n)
  • 92.2 (a)
NTN4 36
  • 92 (a)
(Mus musculus)
Mammalia Ntn4 35
  • 85.33 (n)
  • 89.95 (a)
Ntn4 16
Ntn4 36
  • 90 (a)
(Monodelphis domestica)
Mammalia NTN4 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia NTN4 36
  • 78 (a)
(Rattus norvegicus)
Mammalia Ntn4 35
  • 85.7 (n)
  • 89.79 (a)
(Gallus gallus)
Aves NTN4 35
  • 72.39 (n)
  • 75.12 (a)
NTN4 36
  • 74 (a)
(Anolis carolinensis)
Reptilia NTN4 36
  • 74 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32478 35
(Danio rerio)
Actinopterygii ntn4 35
  • 59.12 (n)
  • 56.34 (a)
ntn4 36
  • 48 (a)
Species with no ortholog for NTN4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTN4 Gene

Gene Tree for NTN4 (if available)
Gene Tree for NTN4 (if available)

Paralogs for NTN4 Gene

Paralogs for NTN4 Gene

Selected SIMAP similar genes for NTN4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NTN4: view

Variants for NTN4 Gene

Sequence variations from dbSNP and Humsavar for NTN4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs719722 -- 95,688,616(+) ACCCA(A/G)TGGCA intron-variant
rs728661 -- 95,677,544(+) AATCC(C/T)AAGCA intron-variant
rs877312 -- 95,674,680(-) TCCCA(C/T)AAGTT intron-variant
rs933632 -- 95,684,424(-) ctact(C/T)gggag intron-variant
rs1345539 -- 95,675,741(-) AAAGC(A/G)GACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTN4 Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv455692 CNV Gain 19166990
nsv526022 CNV Loss 19592680
nsv833 CNV Insertion 18451855

Relevant External Links for NTN4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTN4 Gene

Disorders for NTN4 Gene

Relevant External Links for NTN4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NTN4: view

No data available for UniProtKB/Swiss-Prot for NTN4 Gene

Publications for NTN4 Gene

  1. A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin. Identification, expression, and functional characterization. (PMID: 11038171) Koch M. … Burgeson R.E. (J. Cell Biol. 2000) 2 3 4 23
  2. Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain. (PMID: 15519678) Zhang C. … He F. (Brain Res. Mol. Brain Res. 2004) 3 23
  3. Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. (PMID: 17174565) Qin S. … Zhang C. (Mol. Cell. Neurosci. 2007) 3 23
  4. Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. (PMID: 17545519) Esseghir S. … Isacke C.M. (Clin. Cancer Res. 2007) 3 23
  5. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. (PMID: 18719102) Lejmi E. … PlouAt J. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23

Products for NTN4 Gene

Sources for NTN4 Gene

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