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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTN4 Gene

protein-coding   GIFtS: 57
GCID: GC12M095984

netrin 4
 Explore 6 diseases affiliated with
NTN4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NTN4    

Aliases
for NTN4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Netrin 41 2
Hepar-Derived Netrin-Like Protein2 3
PRO30912
Beta-Netrin1
Netrin-41
Beta-Netrin1

External Ids:    HGNC: 136581   Entrez Gene: 592772   Ensembl: ENSG000000745277   OMIM: 6104015   UniProtKB: Q9HB633   

Export aliases for NTN4 gene to outside databases

Previous GC identifers: GC12M095483 GC12M096415 GC12M094554 GC12M093118


Summaries
for NTN4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NTN4:
NTN4 belongs to a family of proteins related to laminins (see LAMA1, MIM 150320) Koch et al. (2000) (PubMed
11038171).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63
Function: May play an important role in neural, kidney and vascular development. Promotes neurite elongation from
olfactory bulb explants




Genomic Views
for NTN4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NTN4 gene promoter:
         Sox5   AML1a   Pax-2   Pax-2a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   AP-2gamma   POU3F2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NTN4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NTN4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTN4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q22   Ensembl cytogenetic band:  12q22   HGNC cytogenetic band: 12q22

NTN4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTN4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M095984:  view genomic region     (about GC identifiers)

Start:
 96,051,583 bp from pter      End:
 96,184,930 bp from pter
Size:
 133,348 bases      Orientation:
 minus strand

Proteins
for NTN4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63 (See protein sequence)
Recommended Name: Netrin-4 precursor  
Size: 628 amino acids; 70071 Da
Subunit: May form a homodimer
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component
Secondary accessions: B2RNC2 Q658K9 Q7L3F1 Q7L9D6 Q7Z5B6 Q9BZP1 Q9NT44 Q9P133
Alternative splicing: 3 isoforms:  Q9HB63-1   Q9HB63-2   Q9HB63-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NTN4: NX_Q9HB63

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9HB63

    • NTN4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_067052.2  
    ENSEMBL proteins: 
     ENSP00000340998   ENSP00000339436   ENSP00000444432   ENSP00000447292   ENSP00000447594  
    Reactome Protein details: Q9HB63
    Human Recombinant Protein Products: 
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    R&D Systems Recombinant & Natural Proteins for NTN4 (Netrin-4)
    Enzo Life Sciences proteins for NTN4
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: NTN4
    OriGene Custom Protein Services for NTN4 
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    Novus Biologicals NTN4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005604basement membrane IEA--
    GO:0005886plasma membrane TAS--


    NTN4 for ontologies           About GeneDecksing



    NTN4 Antibody Products: 
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    Protein Domains /
    Families
    for NTN4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NTN4 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR008993 TIMP-like_OB-fold
     IPR008211 Laminin_N
     IPR001134 Netrin_domain
     IPR002049 EGF_laminin
     IPR018933 Netrin_module_non-TIMP

    Graphical View of Domain Structure for InterPro Entry Q9HB63

    ProtoNet protein and cluster: Q9HB63

    1 Blocks protein family: IPB001134 Netrin

    UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63
    Similarity: Contains 3 laminin EGF-like domains
    Similarity: Contains 1 laminin N-terminal domain
    Similarity: Contains 1 NTR domain


    Function
    for NTN4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63
    Function: May play an important role in neural, kidney and vascular development. Promotes neurite elongation from
    olfactory bulb explants

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTN4
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate NTN4 (see all 47):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-449a hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: NTN4 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: NTN4
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NTN4

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTN4 (see all 3)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTN4 

    Cell Line
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    Search LifeMap BioReagents cell lines for NTN4

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN4

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043237laminin-1 binding IEA--


    NTN4 for ontologies           About GeneDecksing



    Pathways & Interactions
    for NTN4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    2Axon guidance
    		Axon guidance1.00
    3Netrin-1 signaling
    		Netrin-1 signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for NTN4
        Developmental Biology
    Netrin-1 signaling
    Axon guidance


    1         Kegg Pathway  (Kegg details for NTN4):
        Axon guidance


    NTN4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NTN4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/19 Interacting proteins for NTN4 (Q9HB632, 3 ENSP000003409984) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PLSCR1O151622, 3, ENSP000003454944MINT-66345 I2D: score=5 STRING: ENSP00000345494
    ADAMTSL4Q6UY143, ENSP000002716434I2D: score=5 STRING: ENSP00000271643
    KRTAP5-9P263713I2D: score=1 
    MMS19ENSP000003598184STRING: ENSP00000359818
    RGS20ENSP000002973134STRING: ENSP00000297313
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007411axon guidance TAS--
    GO:0016322neuron remodeling IEA--
    GO:0060668regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling IEA--


    NTN4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NTN4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NTN4
    Search CenterWatch for drugs/clinical trials and news about NTN4 / NET4 

    Transcripts
    for NTN4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NTN4 gene: 
    NM_021229.3  

    Unigene Cluster for NTN4:

    Netrin 4
    Hs.201034  [show with all ESTs]
    Unigene Representative Sequence: NM_021229
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343702(uc001tei.3 uc009ztf.3) ENST00000344911(uc009ztg.3)
    ENST00000538383 ENST00000553059 ENST00000550074 ENST00000552603 ENST00000547980


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTN4
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate NTN4 (see all 47):
    hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-106a hsa-miR-449a hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: NTN4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTN4 (see all 7)
    OriGene shRNA RFP: NTN4
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTN4
    Clone
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    GenScript: all cDNA clones in your preferred vector: NTN4 (NM_021229)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTN4 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTN4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTN4

    Additional cDNA sequence: 

    AF119916.3 AF278532.1 AF297711.1 AK024691.1 AK026833.1 AK226070.1 AK290591.1 AK315796.1 
    AL137540.1 AL833767.1 AY330211.1 BC013591.1 BC136798.1 BC136799.1 Z50158.1 

    9 DOTS entries:

    DT.415047  DT.95277496  DT.99945024  DT.121211282  DT.440466  DT.91719831  DT.40120268  DT.91868157 
    DT.40267537 

    24/143 AceView cDNA sequences (see all 143):

    AI207710 AI927505 AI493056 BU683251 AF119916 CD630787 BC013591 AA513296 
    AA298498 CD676656 BF112106 AI702544 AU280152 AL833767 BQ774632 AI432592 
    R76614 AA342502 CB305456 D62343 AL137540 BM982445 AA252946 BU620432 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NTN4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:              -                                                                     
    SP2:              -                                               -                     
    SP3:                                                                                    


    ECgene alternative splicing isoforms for NTN4

    Expression
    for NTN4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTN4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACACAGTGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NTN4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See NTN4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTN4

    SOURCE GeneReport for Unigene cluster: Hs.201034

    UniProtKB/Swiss-Prot: NET4_HUMAN, Q9HB63
    Tissue specificity: Expressed in kidney, spleen, mammary gland, aorta, heart, ovary, prostate and fetal spleen

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN4

    Orthologs
    for NTN4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NTN4 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NTN41 netrin 4 72.55(n)
    75.41(a)    		   417914  XM_416155.2  XP_416155.2 
    lizard
    (Anolis carolinensis)    		 Reptilia NTN46
    		 --
    		 74(a)
    		 1 ↔ 1
    		 5(30687363-30726237)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.324782 Xenopus laevis transcribed sequence with weak similarity more 70.62(n)    BJ632828.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ntn41 netrin 4 59.16(n)
    56.41(a)    		   561440  NM_001037686.1  NP_001032775.1 


    ENSEMBL Gene Tree for NTN4 (if available)
    TreeFam Gene Tree for NTN4 (if available) 

    Paralogs
    for NTN4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTN4 gene
    LAMA12  NTN52  LAMA32  LAMA22  LAMB22  LAMC12  LAMC22  LAMA52  
    NTN32  LAMB32  LAMC32  LAMA42  NTN12  NTNG12  USH2A2  LAMB42  
    NTNG22  LAMB12  
    5 SIMAP similar genes for NTN4 using alignment to 3 protein entries:     NET4_HUMAN (see all proteins):
    LAMB3    LAMB4    unknown    LAMB1    LAMB2

    NTN4 for paralogs           About GeneDecksing



    Genomic Variants
    for NTN4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2473 NCBI SNPs in NTN4 are shown (see all 2473)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs671979301,2
    		C,--93122575(+) AGAAT-/AAAAAA 1 -- int12Minor allele frequency- A:0.00NA CSA 4
    rs2022211271,2
    		C--93122575(-) TTTTTA/TANNNN 1 -- int10--------
    rs1860512911,2
    		--96051147(+) TGCAGA/GTGAAA 1 -- int10--------
    rs79597491,2
    		C,F,H,--96051177(+) ATGTTT/CAGTAT 1 -- int118Minor allele frequency- C:0.10NS EA NA CSA WA 2341
    rs47625961,2
    		C,F,A,H,--96051418(+) TACAGA/GAAATA 1 -- int122Minor allele frequency- G:0.37NS EA NA WA 2762
    rs1384546361,2
    		--96051463(+) ACCCCA/GGAGTA 1 -- int10--------
    rs1441118761,2
    		--96051617(+) AAATAC/TAAAAA 1 -- ut310--------
    rs1474252651,2
    		--96051638(+) AAGCA-/ATATATA 1 -- ut310--------
    rs2008861341,2
    		--96051676(+) CAGAG-/AAAAAA 1 -- ut310--------
    rs86991,2
    		C,F,A,H,--96051883(-) CAGTTT/CTCCTC 1 -- ut31 trp326Minor allele frequency- C:0.44MN NS EA NA WA CSA 2857

    HapMap Linkage Disequilibrium report for NTN4 (96051583 - 96184930 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NTN4
         1 Indel: 39925

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for NTN4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NTN4 for disorders           About GeneDecksing

    OMIM gene information: 610401    OMIM disorders: --

    6 diseases for NTN4:    About MalaCards
    breast carcinoma    colorectal cancer    breast cancer    carcinoma
    prostatitis    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: NTN4 (3 documents)

    Export disorders for NTN4 gene to outside databases

    Publications
    for NTN4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTN4 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with NTN4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin. Identification, expression, and functional characterization. (PubMed id 11038171)1, 2, 3, 9 Koch M.... Burgeson R.E. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. (PubMed id 17174565)1, 9 Qin S....Zhang C. (2007)
    5. Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. (PubMed id 18719102)1, 9 Lejmi E....Plouet J. (2008)
    6. Identification of a novel alternative splicing form of human netrin-4 and analyzing the expression patterns in adult rat brain. (PubMed id 15519678)1, 9 Zhang C....He F. (2004)
    7. Netrin-4 regulates angiogenic responses and tumor cell growth. (PubMed id 19094984)1, 9 Nacht M....Jiang Y. (2009)
    8. Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. (PubMed id 17545519)1, 9 Esseghir S....Isacke C.M. (2007)
    9. Identification and localization of netrin-4 and neogen in in human first trimester and term placenta. (PubMed id 22705235)1 Dakouane-Giudicelli M....de Mazancourt P. (2012)
    10. Netrin-4 promotes glioblastoma cell proliferation thro ugh integrin b4 signaling. (PubMed id 22496621)1 Hu Y....Hyytiainen M. (2012)

    External Searches for NTN4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing NTN4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 59277 HGNC: 13658 AceView: NTN4 Ensembl:ENSG00000074527 euGenes: HUgn59277
    ECgene: NTN4 Kegg: 59277 H-InvDB: NTN4

    Other Databases showing NTN4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NTN4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTN4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NTN4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NTN4 gene:
    Search GeneIP for patents involving NTN4

    Licensable Technologies for NTN4 gene:
     Tufts University:  Beta Netrin and uses thereof
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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