NTN3 Gene
protein-coding GIFtS: 47
GCID: GC16P002521
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netrin 3(Previous names: netrin 2 (chicken)-like, netrin 2-like (chicken) )
(Previous symbol: NTN2L)
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Aliases
for NTN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Netrin 31 2 | | Netrin 2-Like (Chicken)1 | | NTN2L1 2 3 5 | | Netrin-2, Chicken, Homolog Of, Like2 | | Netrin-2-Like Protein2 3 | | Netrin-31 | | Netrin 2 (Chicken)-Like1 | | |
Export aliases for NTN3 gene to outside databasesPrevious GC identifer: GC16P002462 |
Summaries
for NTN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NET3_HUMAN, O00634Function: Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity)
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Genomic Views
for NTN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NTN3 gene promoter:
Elk-1 Pax-5 Pax-2a AP-4 Nkx2-5 Tal-1beta CREB AREB6 HSF2 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NTN3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTN3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3NTN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P002521: view genomic region
(about GC identifiers)
Start:
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2,521,500 bp from pter |
End:
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2,524,146 bp from pter |
Size:
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2,647 bases |
Orientation:
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plus strand |
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Proteins
for NTN3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NET3_HUMAN, O00634 (See
protein sequence)Recommended Name: Netrin-3 precursor Size: 580 amino acids; 61466 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)Explore the universe of human proteins at neXtProt for NTN3: NX_O00634
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O00634
NTN3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_006172.1
ENSEMBL proteins: ENSP00000293973 Reactome Protein details: O00634
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
NTN3 for ontologies About GeneDecksing
NTN3 Antibody Products:
Assay Products for NTN3: |
Protein
Domains /
Families
for NTN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NTN3 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O00634ProtoNet protein and cluster: O00634 3 Blocks protein families: IPB001134 Netrin IPB002049 Laminin-type EGF-like domain IPB008212 Laminin
UniProtKB/Swiss-Prot: NET3_HUMAN, O00634Similarity: Contains 3 laminin EGF-like domainsSimilarity: Contains 1 laminin N-terminal domainSimilarity: Contains 1 NTR domain |
Function
for NTN3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: NET3_HUMAN, O00634Function: Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTN3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: NTN3 (NM_006181) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005102 | receptor binding |
IEA | -- |
NTN3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for NTN3:
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Pathways & Interactions
for NTN3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of p38 alpha/beta MAPK | | | 2 | Axon guidance | | | 3 | Axon guidance | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for NTN3
1 
Kegg Pathway (Kegg details for NTN3):
NTN3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NTN3
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for NTN3 (O006343 ENSP000002939734) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
NTN3 for ontologies About GeneDecksing
|
Drugs & Compounds
for NTN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NTN3
Search CenterWatch for drugs/clinical trials and news about NTN3 / NET3
|
Transcripts
for NTN3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NTN3 gene: NM_006181.2 Unigene Cluster for NTN3: Netrin 3 Hs.158336 [show with all ESTs]Unigene Representative Sequence: NM_0061811 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000293973(uc002cqj.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTN3 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTN3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NTN3 (NM_006181) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NTN3 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NTN3 |
Additional cDNA sequence: U86759.1 1 DOTS entry: DT.404096 4 AceView cDNA sequences: BF512861 U86759 NM_006181 AI951694
GeneLoc Exon Structure
|
Expression
for NTN3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NTN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See NTN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NTN3
SOURCE GeneReport for Unigene cluster: Hs.158336
UniProtKB/Swiss-Prot: NET3_HUMAN, O00634Tissue specificity: Spinal cord
SABiosciences Expression via Pathway-Focused PCR Array including NTN3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTN3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NTN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTN3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN3 |
Orthologs
for NTN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for NTN3 gene from 5/19 species (see all 19) About this table
ENSEMBL Gene Tree for NTN3 (if available)
TreeFam Gene Tree for NTN3 (if available) |
Paralogs
for NTN3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NTN3 gene
- NTN42 LAMA12 NTN52 LAMA32 LAMA22 LAMB22 LAMC12 LAMC22
- LAMA52 LAMB32 LAMC32 LAMA42 NTN12 NTNG12 USH2A2 LAMB42
- LAMB12 NTNG22
2 SIMAP similar genes for NTN3 using alignment to 1 protein entry: NET3_HUMAN:NTN1 LAMC3
NTN3 for paralogs About GeneDecksing
|
Genomic Variants
for NTN3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NTN3 (2521500 - 2524146 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NTN3
3 CNVs: 72426 4918 5329 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for NTN3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NTN3 for disorders About GeneDecksing
OMIM gene information: 602349
OMIM disorders: --
10  diseases for NTN3: About MalaCardstuberous sclerosis, type 2 tuberous sclerosis mantle cell lymphoma polycystic kidney disease
chronic lymphocytic leukemia lymphocytic leukemia kidney disease leukemia
prostatitis neuronitis
Export disorders for NTN3 gene to outside databases
|
Publications
for NTN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NTN3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NTN3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The NTN2L gene encoding a novel human netrin maps to the autosomal dominant polycystic kidney disease region on chromosome 16p13.3. (PubMed id 9143507)1, 2, 3, 9 Van Raay T.J....Burn T.C. (1997)
- Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. (PubMed id 10366627)1, 3, 9 Wang H....Tessier-Lavigne M. (1999)
- Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3. (PubMed id 8828041)1, 2 Burn T.C.... Landes G.M. (1996)
- Autocrine netrin function inhibits glioma cell motili ty and promotes focal adhesion formation. (PubMed id 21980448)1 Jarjour A.A....Kennedy T.E. (2011)
- Close encounters: regulation of vertebrate skeletal m yogenesis by cell-cell contact. (PubMed id 15923648)1 Krauss R.S....Kang J.S. (2005)
- Quantification of expression of netrins, slits and their receptors in human prostate tumors. (PubMed id 12471613)1 Latil A....Cussenot O. (2003)
- Immunoglobulin V(H) gene mutational analysis suggests that blastic variant of mantle cell lymphoma derives from different stages of B-cell maturation. (PubMed id 10634642)1 Laszlo T....Matolcsy A. (2000)
- Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire. (PubMed id 9887257)1 de Wildt R.M....Winter G. (1999)
- Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. (PubMed id 10477713)1 Hamblin T.J....Stevenson F.K. (1999)
- Expression of mRNA for axon guidance molecules, such as semaphorin-III, netrins and neurotrophins, in human osteoblasts and osteoclasts. (PubMed id 10996153)9 Togari A....Koshihara Y. (2000)
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External Searches for NTN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing NTN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NTN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NTN3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NTN3 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NTN3 gene:
Search GeneIP for patents involving NTN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NTN3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for NTN3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTN3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTN3 | | | OriGene Protein Over-expression Lysate for NTN3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NTN3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTN3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTN3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NTN3 | | OriGene Custom Protein Services for NTN3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NTN3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NTN3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTN3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTN3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTN3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTN3 |
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 |  |  |  | |
| | | | Search Tocris compounds for NTN3 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN3 |
|  |  |  | | | | Search ThermoFisher Antibodies for NTN3 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NTN3 |
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