Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NTN1 Gene

protein-coding   GIFtS: 64
GCID: GC17P008924

Netrin 1

  Search for NTN1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Netrin 11 2
NTN1L2 3 5
Epididymis Tissue Protein Li 131P2 3
Netrin-11
Netrin 1, Mouse, Homolog Of2
netrin-12

External Ids:    HGNC: 80291   Entrez Gene: 94232   Ensembl: ENSG000000653207   OMIM: 6016145   UniProtKB: O956313   

Export aliases for NTN1 gene to outside databases

Previous GC identifers: GC17P009272 GC17P010016 GC17P008867 GC17P009125 GC17P008865


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for NTN1 Gene:
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been
defined; however, netrin is thought to be involved in axon guidance and cell migration during development.
Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer
development. (provided by RefSeq, Jul 2008)

GeneCards Summary for NTN1 Gene:
NTN1 (netrin 1) is a protein-coding gene. An important paralog of this gene is NTNG1.

UniProtKB/Swiss-Prot: NET1_HUMAN, O95631
Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with
either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a
survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in
tumorigenesis by regulating apoptosis

Gene Wiki entry for NTN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NTN1 gene promoter:
         ER-alpha   Elk-1   LHX3b/Lhx3b   NF-1   Pax-5   p53   Lmo2   Nkx2-5   C/EBPalpha   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NTN1 promoter sequence
   Search Chromatin IP Primers for NTN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13-p12   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13-p12

NTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTN1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P008924:  view genomic region     (about GC identifiers)

Start:
8,924,859 bp from pter      End:
9,147,317 bp from pter
Size:
222,459 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NET1_HUMAN, O95631 (See protein sequence)
Recommended Name: Netrin-1 precursor  
Size: 604 amino acids; 67748 Da
Subunit: Binds to its receptors; DCC, DSCAM, UNC5A, UNC5B, UNC5C and probably UNC5D
Secondary accessions: E9KL51

Explore the universe of human proteins at neXtProt for NTN1: NX_O95631

Explore proteomics data for NTN1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn95, Asn116, Asn131, Asn417, Thr460, Thr461
  • Modification sites at PhosphoSitePlus

  • See NTN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004813.2  
    ENSEMBL proteins: 
     ENSP00000173229   ENSP00000389375   ENSP00000443259   ENSP00000441611  
    Reactome Protein details: O95631

    NTN1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for NTN1 (Netrin-1)
    Enzo Life Sciences proteins for NTN1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for NTN1
    GenScript Custom Purified and Recombinant Proteins Services for NTN1
    Novus Biologicals NTN1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for NTN1 

    NTN1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for NTN1 (Netrin-1)
    OriGene Antibodies for NTN1
    OriGene Custom Antibody Services for NTN1
    Novus Biologicals NTN1 Antibodies
    Abcam antibodies for NTN1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for NTN1
    LSBio Antibodies in human, mouse, rat for NTN1

    NTN1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NTN1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NTN1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for NTN1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    NTN: Netrins

    Selected InterPro protein domains (see all 7):
     IPR008993 TIMP-like_OB-fold
     IPR008211 Laminin_N
     IPR013032 EGF-like_CS
     IPR001134 Netrin_domain
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry O95631

    ProtoNet protein and cluster: O95631

    3 Blocks protein domains:
    IPB001134 Netrin
    IPB002049 Laminin-type EGF-like domain
    IPB008212 Laminin


    UniProtKB/Swiss-Prot: NET1_HUMAN, O95631
    Similarity: Contains 3 laminin EGF-like domains
    Similarity: Contains 1 laminin N-terminal domain
    Similarity: Contains 1 NTR domain


    Find genes that share domains with NTN1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NET1_HUMAN, O95631
    Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with
    either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a
    survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in
    tumorigenesis by regulating apoptosis

         Genatlas biochemistry entry for NTN1:
    netrin 1,axon outgrow-promoting protein with homology to chicken ntn and C elegans UNC-6,ubiquitously
    expressed,interacting with DCC,mediated by cytoplasmic Ca2+ signals,markedly reduced in brain tumors and
    neuroblastomas

         Summary: 
    During embryonic development, NTN1 as signaling molecule affects the following cells:
    Brain: Fetal Dopaminergic Neurons (Substantia Nigra pars Compacta), Fetal Dopaminergic Neurons (Ventral Tegmental Area)       to see all 2 cells
    Endothelium: Endothelial Tip Cells (Arteries)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10102268
         
    Find genes that share ontologies with NTN1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for NTN1:
     Decreased G3BP1 protein expres 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ntn1):
     behavior/neurological  cellular  endocrine/exocrine gland  hearing/vestibular/ear  integument 
     mortality/aging  nervous system 

    Find genes that share phenotypes with NTN1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NTN1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NTN1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTN1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTN1

    miRNA
    Products:
        
    miRTarBase miRNAs that target NTN1:
    hsa-mir-148b-3p (MIRT019443), hsa-mir-1296-5p (MIRT036113), hsa-mir-423-3p (MIRT042477)

    Block miRNA regulation of human, mouse, rat NTN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NTN1 (see all 90):
    hsa-miR-323-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-374a hsa-miR-93 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-3148
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NTN1
    Predesigned siRNA for gene silencing in human, mouse, rat NTN1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NTN1

    Clone
    Products:
         
    OriGene clones in human, mouse for NTN1 (see all 6)
    OriGene ORF clones in mouse, rat for NTN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NTN1 (NM_001843)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTN1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NTN1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NTN1
    Browse ESI BIO Cell Lines and PureStem Progenitors for NTN1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NET1_HUMAN, O95631: Secreted, extracellular space, extracellular matrix (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytoskeleton1
    endoplasmic reticulum1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with NTN1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for NTN1 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Netrin-1 signaling
    Netrin-1 signaling
    Netrin mediated repulsion signals0.00
    DCC mediated attractive signaling0.00
    Role of second messengers in netrin-1 signaling0.00
    2Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    3Cell junction organization
    Cell-Cell communication0.64
    DSCAM interactions0.00
    4L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    5Spinal Cord Injury
    Spinal Cord Injury


    Find genes that share SuperPaths with NTN1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NTN1
        Notch Signaling Pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NTN1
        PKA Signaling
    Guidance Cues and Growth Cone Motility
    Netrin Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    2 BioSystems Pathways for NTN1
        Spinal Cord Injury
    Alpha6-Beta4 Integrin Signaling Pathway

    5 Reactome Pathways for NTN1
        Netrin mediated repulsion signals
    Netrin-1 signaling
    Role of second messengers in netrin-1 signaling
    DCC mediated attractive signaling
    DSCAM interactions


    1 Kegg Pathway  (Kegg details for NTN1):
        Axon guidance

        Pathway & Disease-focused RT2 Profiler PCR Array including NTN1: 
              Neurogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NTN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NTN1 (O956313 ENSP000001732294) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEO1Q928593, ENSP000002619084I2D: score=1 STRING: ENSP00000261908
    UNC5AQ6ZN443, ENSP000003327374I2D: score=1 STRING: ENSP00000332737
    DCCP431463, ENSP000003891404I2D: score=4 STRING: ENSP00000389140
    UNC5CO951853, ENSP000004060224I2D: score=1 STRING: ENSP00000406022
    ADORA2BP292753, ENSP000003045014I2D: score=1 STRING: ENSP00000304501
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006915apoptotic process IEA--
    GO:0007409axonogenesis ----
    GO:0007411axon guidance TAS--
    GO:0008284positive regulation of cell proliferation IEA--

    Find genes that share ontologies with NTN1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NTN1 (NET1)

    9 Novoseek inferred chemical compound relationships for NTN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alar 32.1 1 8982157 (1)
    matrigel 22 2 18461079 (1), 19570425 (1), 17459228 (1)
    heparan sulfate 9.78 1 9341129 (1)
    tyrosine 5.28 6 18253061 (2), 15494732 (1), 16321979 (1), 18616430 (1) (see all 5)
    cyclic amp 5.17 2 12352982 (2)
    cholesterol 0 1 15066264 (1)
    lipid 0 5 18616430 (2), 15066264 (1)
    calcium 0 9 10638760 (4), 16014732 (2), 19650914 (1)
    heparin 0 3 9341129 (1), 10799289 (1)



    Find genes that share compounds with NTN1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NTN1 gene: 
    NM_004822.2  

    Unigene Cluster for NTN1:

    Netrin 1
    Hs.660885  [show with all ESTs]
    Unigene Representative Sequence: NM_004822
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000173229(uc002glw.4) ENST00000436734 ENST00000538852 ENST00000546090

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NTN1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NTN1 (see all 90):
    hsa-miR-323-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-374a hsa-miR-93 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-3148
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NTN1
    Predesigned siRNA for gene silencing in human, mouse, rat NTN1
    Clone
    Products:
         
    OriGene clones in human, mouse for NTN1 (see all 6)
    OriGene ORF clones in mouse, rat for NTN1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NTN1 (NM_001843)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTN1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NTN1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for NTN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NTN1
      QuantiTect SYBR Green Assays in human, mouse, rat NTN1
      QuantiFast Probe-based Assays in human, mouse, rat NTN1

    Additional mRNA sequence: 

    BC092429.1 GU727649.1 U75586.1 

    3 DOTS entries:

    DT.406274  DT.91691298  DT.75185888 

    6 AceView cDNA sequences:

    NM_004822 BX109597 U75586 BM924774 AI634709 BF033805 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NTN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGAACTAA
    NTN1 Expression
    About this image


    NTN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 11 entries
             Late Floor Plate Cells Mesencephalic Floor Plate
             Metencephalon
             Floor plate-like cells
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Early Caudal Floor Plate Cells Diencephalic Floor Plate
             Cerebellum
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
    NTN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NTN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.660885

    UniProtKB/Swiss-Prot: NET1_HUMAN, O95631
    Tissue specificity: Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon,
    liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein
    level)

        Pathway & Disease-focused RT2 Profiler PCR Array including NTN1: 
              Neurogenesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for NTN1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NTN1
    QuantiTect SYBR Green Assays in human, mouse, rat NTN1
    QuantiFast Probe-based Assays in human, mouse, rat NTN1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for NTN1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntn11 , 5 netrin 11, 5 92.55(n)1
    99.17(a)1
      11 (41.45 cM)5
    182081  NM_008744.21  NP_032770.21 
     682093645 
    chicken
    (Gallus gallus)
    Aves NTN11 netrin 1 87.42(n)
    89.54(a)
      396389  NM_205419.1  NP_990750.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTN16
    netrin 1
    81(a)
    1 ↔ 1
    2(105387248-105536162)
    African clawed frog
    (Xenopus laevis)
    Amphibia ntn1-A2 netrin 1 76.21(n)    AF033341.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntn12 netrin 1 78.75(n)   30192  AF017420.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NetA3
    NetB1
    axon guidance3
    Netrin-B1
    51(a)
    (best of 2)3
    61.65(n)1
    59.53(a)1
      324001  NM_078600.41  NP_511155.11 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-61 , 3 Expression: P lineage, sheath_cells,
    head, neurons, more3
    unc-61
    51(a)3
    54.55(n)1
    54.37(a)1
      X(6925001-6931889)3
    1809611  NM_076764.31  NP_509165.11 


    ENSEMBL Gene Tree for NTN1 (if available)
    TreeFam Gene Tree for NTN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NTN1 gene
    NTNG12  NTN32  LAMB32  NTN42  NTN52  NTNG22  
    10 SIMAP similar genes for NTN1 using alignment to 2 protein entries:     NET1_HUMAN (see all proteins):
    NTN3    LAMC3    LAMA3    LAMB4    NTNG1    LAMA5
    LAMA1    LAMB1    NTN5    unknown

    Find genes that share paralogs with NTN1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NTN1 (see all 5142)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790275541,2
    C,F--8922897(+) CTATAA/CTATTC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs763535471,2
    F--8923029(+) ACCCAG/CGTACC 1 -- us2k13Minor allele frequency- C:0.05CSA WA 120
    rs1923392581,2
    --8923102(+) CAGGTC/TACCAT 1 -- us2k10--------
    rs1411797581,2
    --8923114(+) GTTAAC/TCATTT 1 -- us2k10--------
    rs1450082381,2
    C--8923195(+) GAAATC/TCTTTC 1 -- us2k10--------
    rs1483123811,2
    --8923204(+) TCTGCC/TACAAG 1 -- us2k10--------
    rs1414729471,2
    --8923244(+) AGTGTA/GGTAAA 1 -- us2k10--------
    rs1504398281,2
    C--8923289(+) GGGTAA/GGAAGA 1 -- us2k10--------
    rs781921431,2
    F--8923325(+) ATGGAT/CTTATT 1 -- us2k13Minor allele frequency- C:0.05CSA WA 120
    rs1844536231,2
    --8923562(+) CTTTTA/CATCCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NTN1 (8924859 - 9147317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NTN1 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1003228CNV Deletion20482838
    esv2715627CNV Deletion23290073
    esv2715625CNV Deletion23290073
    esv2715630CNV Deletion23290073
    esv2715626CNV Deletion23290073
    esv2675061CNV Deletion23128226
    esv2670723CNV Deletion23128226
    esv2715628CNV Deletion23290073
    nsv1971CNV Insertion18451855
    esv25265CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NTN1
    DNA2.0 Custom Variant and Variant Library Synthesis for NTN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601614    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for NTN1:
    Colorectal cancer

    Find genes that share disorders with NTN1           About GenesLikeMe

    5 Novoseek inferred disease relationships for NTN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 69.6 41 19721007 (3), 19858080 (2), 15811950 (1), 15956977 (1) (see all 28)
    colorectal carcinoma 42.1 3 17549567 (1), 20431009 (1), 16762451 (1)
    cancer 11.5 11 17334389 (3), 15491747 (2), 19543238 (1), 19934758 (1) (see all 7)
    tumors 0.621 35 18353983 (4), 19543238 (3), 17549567 (3), 18922894 (3) (see all 10)
    neovascularization 0 2 18461079 (2)

    Genetic Association Database (GAD): NTN1
    Human Genome Epidemiology (HuGE) Navigator: NTN1 (1 document)

    Export disorders for NTN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NTN1 gene, integrated from 10 sources (see all 175):
    (articles sorted by number of sources associating them with NTN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. (PubMed id 9950216)1, 2, 3, 9 Meyerhardt J.A.... Fearon E.R. (Cell Growth Differ. 1999)
    2. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (Mol. Cell. Proteomics 2010)
    3. DSCAM functions as a netrin receptor in commissural axon pathfinding. (PubMed id 19196994)1, 2 Liu G.... Wu J.Y. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    4. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. (PubMed id 15343335)1, 2 Mazelin L.... Mehlen P. (Nature 2004)
    5. Interference with netrin-1 and tumor cell death in non-small cell lung cancer. (PubMed id 19211441)1, 9 Delloye-Bourgeois C....Bernet A. (J. Natl. Cancer Inst. 2009)
    6. Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1. (PubMed id 18653556)1, 9 Moore S.W....Kennedy T.E. (Development 2008)
    7. Netrin-1 inhibits sprouting angiogenesis in developing avian embryos. (PubMed id 18439993)1, 9 BouvrAce K....Pardanaud L. (Dev. Biol. 2008)
    8. Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor. (PubMed id 18922894)1, 9 Roperch J.P....Gespach C. (Cancer Res. 2008)
    9. Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis. (PubMed id 15491747)1, 9 Kato H.D....Wake N. (Gynecol. Oncol. 2004)
    10. Netrin-1 dampens pulmonary inflammation during acute lung injury. (PubMed id 20075388)1, 9 Mirakaj V....Rosenberger P. (Am. J. Respir. Crit. Care Med. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9423 HGNC: 8029 AceView: NTN1 Ensembl:ENSG00000065320 euGenes: HUgn9423
    ECgene: NTN1 Kegg: 9423 H-InvDB: NTN1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NTN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NTN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NTN1 gene:
    Search GeneIP for patents involving NTN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for NTN1 (Netrin-1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for NTN1 (Netrin-1)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for NTN1   OriGene RNAi products in human, mouse, rat for NTN1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for NTN1  
     OriGene qSTAR qPCR primer pairs in human, mouse for NTN1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for NTN1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NTN1   OriGene Custom Protein Services for NTN1  

     
     
     Block miRNA regulation of human, mouse, rat NTN1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NTN1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTN1 Predesigned siRNA for gene silencing in human, mouse, rat NTN1
     QuantiFast Probe-based Assays in human, mouse, rat NTN1 QuantiTect SYBR Green Assays in human, mouse, rat NTN1
     PCR Arrays including human, mouse, rat NTN1 Search Chromatin IP Primers for NTN1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NTN1  GeneGlobe Interaction Network for NTN1
     Regulatory tfbs in NTN1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for NTN1 GenScript cDNA clones with any tag delivered in your preferred vector for NTN1
     GenScript Custom Assay Services for NTN1 GenScript Custom overexpressing Cell Line Services for NTN1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NTN1 (NET1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for NTN1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NTN1 antibodies
     NTN1 proteins
     Antibodies for NTN1
     See all of Abcam's Antibodies, Kits and Proteins for NTN1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for NTN1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NTN1
     SwitchGear Promoter luciferase reporter plasmids for NTN1
     ThermoFisher Antibodies for NTN1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NTN1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NTN1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NTN1
     LSBio Antibodies in human, mouse, rat for NTN1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for NTN1
      Search eBioscience for proteins for NTN1
      Search eBioscience for elisas for NTN1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NTN1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4