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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTN1 Gene

protein-coding   GIFtS: 62
GCID: GC17P008924

netrin 1
 Explore 25 diseases affiliated with
NTN1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NTN1    

Aliases
for NTN1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Netrin 11 2
NTN1L1 2 3
Epididymis Tissue Protein Li 131P2 3
Netrin 1, Mouse, Homolog Of2
Netrin-11

External Ids:    HGNC: 80291   Entrez Gene: 94232   Ensembl: ENSG000000653207   OMIM: 6016145   UniProtKB: O956313   

Export aliases for NTN1 gene to outside databases

Previous GC identifers: GC17P009272 GC17P010016 GC17P008867 GC17P009125 GC17P008865


Summaries
for NTN1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NTN1:
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been
defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations
and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NET1_HUMAN, O95631
Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC
or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via
its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating
apoptosis

Gene Wiki entry for NTN1


Genomic Views
for NTN1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NTN1 gene promoter:
         ER-alpha   Elk-1   LHX3b/Lhx3b   NF-1   Pax-5   p53   Lmo2   Nkx2-5   C/EBPalpha   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NTN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NTN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13-p12   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13-p12

NTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTN1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P008924:  view genomic region     (about GC identifiers)

Start:
 8,924,859 bp from pter      End:
 9,147,317 bp from pter
Size:
 222,459 bases      Orientation:
 plus strand

Proteins
for NTN1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NET1_HUMAN, O95631 (See protein sequence)
Recommended Name: Netrin-1 precursor  
Size: 604 amino acids; 67748 Da
Subunit: Binds to its receptors; DCC, DSCAM, UNC5A, UNC5B, UNC5C and probably UNC5D
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: E9KL51

Explore the universe of human proteins at neXtProt for NTN1: NX_O95631

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95631

    • NTN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004813.2  
    ENSEMBL proteins: 
     ENSP00000173229   ENSP00000389375   ENSP00000443259   ENSP00000441611  
    Reactome Protein details: O95631
    Human Recombinant Protein Products: 
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    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005604basement membrane IEA--
    GO:0005737cytoplasm IEA--


    NTN1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for NTN1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NTN1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR008993 TIMP-like_OB-fold
     IPR008211 Laminin_N
     IPR013032 EGF-like_CS
     IPR001134 Netrin_domain
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry O95631

    ProtoNet protein and cluster: O95631

    3 Blocks protein families:
    IPB001134 Netrin
    IPB002049 Laminin-type EGF-like domain
    IPB008212 Laminin


    UniProtKB/Swiss-Prot: NET1_HUMAN, O95631
    Similarity: Contains 3 laminin EGF-like domains
    Similarity: Contains 1 laminin N-terminal domain
    Similarity: Contains 1 NTR domain


    Function
    for NTN1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NET1_HUMAN, O95631
    Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC
    or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via
    its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating
    apoptosis

         Genatlas biochemistry entry for NTN1:
    netrin 1,axon outgrow-promoting protein with homology to chicken ntn and C elegans UNC-6,ubiquitously
    expressed,interacting with DCC,mediated by cytoplasmic Ca2+ signals,markedly reduced in brain tumors and
    neuroblastomas

         Summary:  
    During embryonic development, NTN1 as signaling molecule
    affects the following cells: Embryonic Dopaminergic Neurons in Substantia Nigra pars Compacta, Embryonic Dopaminergic Neurons in Ventral Tegmental Area (see all 3).

    miRNA
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    hsa-miR-323-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-374a hsa-miR-93 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-3148
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19196994


    NTN1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NTN1:
     Decreased G3BP1 protein expres 

    Animal Models:
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ntn1):
     behavior/neurological  cellular  endocrine/exocrine gland  hearing/vestibular/ear  integument 
     mortality/aging  nervous system 

    NTN1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NTN1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Activation of cAMP-Dependent PKA
    		Activation of cAMP-Dependent PKA1.00
    		PKA Signaling0.56
    		cAMP Pathway0.77
    2Role of second messengers in netrin-1 signaling
    		Role of second messengers in netrin-1 signaling1.00
    		Phosphorylation of PLCgamma by Netrin-10.40
    3Axon guidance
    		Axon guidance1.00
    		Developmental Biology0.69
    4Netrin-1 signaling
    		Netrin-1 signaling1.00
    		DCC mediated attractive signaling0.33
    5Netrin mediated repulsion signals
    		Netrin mediated repulsion signals1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for NTN1
        Selected targets of Oct-3/4

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NTN1
        PKA Signaling
    Guidance Cues and Growth Cone Motility
    Netrin Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    1 BioSystems Pathway for NTN1 
        Alpha6-Beta4 Integrin Signaling Pathway

    5/9        Reactome Pathways for NTN1 (see all 9)
        Developmental Biology
    Phosphorylation of PLCgamma by Netrin-1
    DSCAM interactions
    Netrin mediated repulsion signals
    Netrin-1 signaling


    1         Kegg Pathway  (Kegg details for NTN1):
        Axon guidance


    NTN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NTN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for NTN1 (O956313 ENSP000001732294) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEO1Q928593, ENSP000002619084I2D: score=1 STRING: ENSP00000261908
    UNC5AQ6ZN443, ENSP000003327374I2D: score=1 STRING: ENSP00000332737
    DCCP431463, ENSP000003891404I2D: score=4 STRING: ENSP00000389140
    UNC5CO951853, ENSP000004060224I2D: score=1 STRING: ENSP00000406022
    ADORA2BP292753, ENSP000003045014I2D: score=1 STRING: ENSP00000304501
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006915apoptotic process IEA--
    GO:0007409axonogenesis ----
    GO:0007411axon guidance TAS--
    GO:0008284positive regulation of cell proliferation IEA--


    NTN1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NTN1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NTN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NTN1
    9 Novoseek chemical compound relationships for NTN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alar 32.1 1 8982157 (1)
    matrigel 22 2 18461079 (1), 19570425 (1), 17459228 (1)
    heparan sulfate 9.78 1 9341129 (1)
    tyrosine 5.28 6 18253061 (2), 15494732 (1), 16321979 (1), 18616430 (1) (see all 5)
    cyclic amp 5.17 2 12352982 (2)
    cholesterol 0 1 15066264 (1)
    lipid 0 5 18616430 (2), 15066264 (1)
    calcium 0 9 10638760 (4), 16014732 (2), 19650914 (1)
    heparin 0 3 9341129 (1), 10799289 (1)

    Search CenterWatch for drugs/clinical trials and news about NTN1 / NET1 

    Transcripts
    for NTN1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NTN1 gene: 
    NM_004822.2  

    Unigene Cluster for NTN1:

    Netrin 1
    Hs.660885  [show with all ESTs]
    Unigene Representative Sequence: NM_004822
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000173229(uc002glw.4) ENST00000436734 ENST00000538852 ENST00000546090


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    hsa-miR-323-3p hsa-miR-106a hsa-miR-218-1* hsa-miR-374a hsa-miR-93 hsa-miR-3613-3p hsa-miR-3116 hsa-miR-3148
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    BC092429.1 GU727649.1 U75586.1 

    3 DOTS entries:

    DT.406274  DT.91691298  DT.75185888 

    6 AceView cDNA sequences:

    NM_004822 U75586 BM924774 BX109597 AI634709 BF033805 

    GeneLoc Exon Structure


    Expression
    for NTN1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATAGAACTAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NTN1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/17 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 17) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural TubeDiencephalic Floor PlateEarly Caudal Floor Plate CellsNeural Ectoderm
    Neural TubeDiencephalic Floor PlateLate Caudal Floor Plate CellsNeural Ectoderm
    Neural TubeMesencephalic Floor PlateEarly Floor Plate CellsNeural Ectoderm
    Neural TubeMesencephalic Floor PlateLate Floor Plate CellsNeural Ectoderm
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    LungLung BudLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Definitive endoderm-like cells (A scalable, suspensi...)

    See NTN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTN1

    SOURCE GeneReport for Unigene cluster: Hs.660885

    UniProtKB/Swiss-Prot: NET1_HUMAN, O95631
    Tissue specificity: Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon,
    liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level)

        SABiosciences Expression via Pathway-Focused PCR Array including NTN1: 
              Neurogenesis in human mouse rat

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    In Situ
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    Orthologs
    for NTN1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for NTN1 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves NTN11 netrin 1 86.86(n)
    88.59(a)    		   396389  NM_205419.1  NP_990750.1 
    lizard
    (Anolis carolinensis)    		 Reptilia NTN16
    		 --
    		 88(a)
    		 1 ↔ 1
    		 2(105387905-105536162)
    African clawed frog
    (Xenopus laevis)    		 Amphibia ntn1-A2 netrin 1 76.21(n)    AF033341.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ntn12 netrin 1 78.75(n)   30192  AF017420.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta NetA3
    NetB1    		 axon guidance3
    Netrin-B1    		 51(a)
    (best of 2)3
    59.87(n)1
    56.51(a)1    		   324001  NM_001169282.11  NP_001162753.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-61 , 3 Expression: P lineage, sheath_cells, head,
    neurons, more3
    Protein UNC-61    		 51(a)3
    54.4(n)1
    54.23(a)1    		   X(6925001-6931889)3
    1809611  NM_076764.21  NP_509165.11 


    ENSEMBL Gene Tree for NTN1 (if available)
    TreeFam Gene Tree for NTN1 (if available) 

    Paralogs
    for NTN1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTN1 gene
    NTN42  LAMA12  NTN52  LAMA32  LAMA22  LAMB22  LAMC12  LAMC22  
    LAMA52  NTN32  LAMB32  LAMC32  LAMA42  NTNG12  USH2A2  LAMB42  
    LAMB12  NTNG22  
    12 SIMAP similar genes for NTN1 using alignment to 2 protein entries:     NET1_HUMAN (see all proteins):
    NTN3    LAMC3    LAMA3    LAMB4    NTNG1    LAMA5
    LAMA1    LAMB1    NTN5    unknown    LAMA2    LAMB2

    NTN1 for paralogs           About GeneDecksing



    Genomic Variants
    for NTN1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4427 NCBI SNPs in NTN1 are shown (see all 4427)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs350234271,2
    		C,--8829169(+) CTCTT-/AATGGT 1 -- int13Minor allele frequency- A:0.17NA CSA 6
    rs790275541,2
    		C,F,--8922897(+) CTATAA/CTATTC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs763535471,2
    		--8923029(+) ACCCAG/CGTACC 1 -- us2k13Minor allele frequency- C:0.05CSA WA 120
    rs1923392581,2
    		--8923102(+) CAGGTC/TACCAT 1 -- us2k10--------
    rs1411797581,2
    		--8923114(+) GTTAAC/TCATTT 1 -- us2k10--------
    rs1450082381,2
    		--8923195(+) GAAATC/TCTTTC 1 -- us2k10--------
    rs1483123811,2
    		--8923204(+) TCTGCC/TACAAG 1 -- us2k10--------
    rs1414729471,2
    		--8923244(+) AGTGTA/GGTAAA 1 -- us2k10--------
    rs1504398281,2
    		--8923289(+) GGGTAA/GGAAGA 1 -- us2k10--------
    rs781921431,2
    		--8923325(+) ATGGAT/CTTATT 1 -- us2k13Minor allele frequency- C:0.05CSA WA 120

    HapMap Linkage Disequilibrium report for NTN1 (8924859 - 9147317 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for NTN1
         2 CNVs: 67130 49947
         1 Indel: 11872

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    Disorders / Diseases
    for NTN1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NTN1 for disorders           About GeneDecksing

    OMIM gene information: 601614    OMIM disorders: --

    20/25 diseases for NTN1 (see all 25):    About MalaCards
    pre-eclampsia    inflammatory bowel disease    eclampsia    embryonal carcinoma
    rheumatoid arthritis    epididymitis    colorectal cancer    colon cancer
    arthritis    osteoarthritis    lung cancer    breast cancer
    ischemia    glioblastoma    carcinoma    cervicitis
    cholesterol    hypoxia    neuroblastoma    retinitis

    1 disease from the University of Copenhagen DISEASES database for NTN1:
    Colorectal cancer

    5 Novoseek disease relationships for NTN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 69.6 41 19721007 (3), 19858080 (2), 15811950 (1), 15956977 (1) (see all 28)
    colorectal carcinoma 42.1 3 17549567 (1), 20431009 (1), 16762451 (1)
    cancer 11.5 11 17334389 (3), 15491747 (2), 19543238 (1), 19934758 (1) (see all 7)
    tumors 0.621 35 18353983 (4), 19543238 (3), 17549567 (3), 18922894 (3) (see all 10)
    neovascularization 0 2 18461079 (2)

    Human Genome Epidemiology (HuGE) Navigator: NTN1 (1 document)

    Export disorders for NTN1 gene to outside databases

    Publications
    for NTN1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTN1 gene, integrated from 9 sources (see all 161):
    (articles sorted by number of sources associating them with NTN1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. (PubMed id 9950216)1, 2, 3, 9 Meyerhardt J.A.... Fearon E.R. (1999)
    2. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (2010)
    3. DSCAM functions as a netrin receptor in commissural axon pathfinding. (PubMed id 19196994)1, 2 Liu G.... Wu J.Y. (2009)
    4. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. (PubMed id 15343335)1, 2 Mazelin L.... Mehlen P. (2004)
    5. Interference with netrin-1 and tumor cell death in non-small cell lung cancer. (PubMed id 19211441)1, 9 Delloye-Bourgeois C....Bernet A. (2009)
    6. Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1. (PubMed id 18653556)1, 9 Moore S.W....Kennedy T.E. (2008)
    7. Netrin-1 inhibits sprouting angiogenesis in developing avian embryos. (PubMed id 18439993)1, 9 Bouvree K....Pardanaud L. (2008)
    8. Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor. (PubMed id 18922894)1, 9 Roperch J.P....Gespach C. (2008)
    9. Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis. (PubMed id 15491747)1, 9 Kato H.D....Wake N. (2004)
    10. Netrin-1 dampens pulmonary inflammation during acute lung injury. (PubMed id 20075388)1, 9 Mirakaj V....Rosenberger P. (2010)

    External Searches for NTN1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NTN1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9423 HGNC: 8029 AceView: NTN1 Ensembl:ENSG00000065320 euGenes: HUgn9423
    ECgene: NTN1 Kegg: 9423 H-InvDB: NTN1

    Other Databases showing NTN1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NTN1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NTN1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for NTN1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NTN1 gene:
    Search GeneIP for patents involving NTN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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