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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTN1 Gene

protein-coding   GIFtS: 63
GCID: GC17P008924

Netrin 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Netrin 11 2
Epididymis Tissue Protein Li 131P2 3
NTN1L2 3
Netrin-11
Netrin 1, Mouse, Homolog Of2
netrin-12

External Ids:    HGNC: 80291   Entrez Gene: 94232   Ensembl: ENSG000000653207   OMIM: 6016145   UniProtKB: O956313   

Export aliases for NTN1 gene to outside databases

Previous GC identifers: GC17P009272 GC17P010016 GC17P008867 GC17P009125 GC17P008865


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTN1 Gene:
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been
defined; however, netrin is thought to be involved in axon guidance and cell migration during development.
Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer
development. (provided by RefSeq, Jul 2008)

GeneCards Summary for NTN1 Gene: 
NTN1 (netrin 1) is a protein-coding gene. Diseases associated with NTN1 include epididymitis, and cleft palate, and among its related super-pathways are Activation of cAMP-Dependent PKA and Axon guidance. GO annotations related to this gene include protein binding. An important paralog of this gene is LAMC1.

UniProtKB/Swiss-Prot: NET1_HUMAN, O95631
Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with
either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a
survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in
tumorigenesis by regulating apoptosis

Gene Wiki entry for NTN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NTN1 gene promoter:
         ER-alpha   Elk-1   LHX3b/Lhx3b   NF-1   Pax-5   p53   Lmo2   Nkx2-5   C/EBPalpha   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): NTN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NTN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13-p12   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13-p12

NTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTN1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P008924:  view genomic region     (about GC identifiers)

Start:
8,924,859 bp from pter      End:
9,147,317 bp from pter
Size:
222,459 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NET1_HUMAN, O95631 (See protein sequence)
Recommended Name: Netrin-1 precursor  
Size: 604 amino acids; 67748 Da
Subunit: Binds to its receptors; DCC, DSCAM, UNC5A, UNC5B, UNC5C and probably UNC5D
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Secondary accessions: E9KL51

Explore the universe of human proteins at neXtProt for NTN1: NX_O95631

Explore proteomics data for NTN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95631

  • NTN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NTN1 Protein Expression
    REFSEQ proteins: NP_004813.2  
    ENSEMBL proteins: 
     ENSP00000173229   ENSP00000389375   ENSP00000443259   ENSP00000441611  
    Reactome Protein details: O95631
    Human Recombinant Protein Products for NTN1: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IEA--
    GO:0005737cytoplasm IEA--

    NTN1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    NTN: Netrins

    5/7 InterPro protein domains (see all 7):
     IPR008993 TIMP-like_OB-fold
     IPR008211 Laminin_N
     IPR013032 EGF-like_CS
     IPR001134 Netrin_domain
     IPR002049 EGF_laminin

    Graphical View of Domain Structure for InterPro Entry O95631

    ProtoNet protein and cluster: O95631

    3 Blocks protein domains:
    IPB001134 Netrin
    IPB002049 Laminin-type EGF-like domain
    IPB008212 Laminin


    UniProtKB/Swiss-Prot: NET1_HUMAN, O95631
    Similarity: Contains 3 laminin EGF-like domains
    Similarity: Contains 1 laminin N-terminal domain
    Similarity: Contains 1 NTR domain


    NTN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NET1_HUMAN, O95631
    Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with
    either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a
    survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in
    tumorigenesis by regulating apoptosis

         Genatlas biochemistry entry for NTN1:
    netrin 1,axon outgrow-promoting protein with homology to chicken ntn and C elegans UNC-6,ubiquitously
    expressed,interacting with DCC,mediated by cytoplasmic Ca2+ signals,markedly reduced in brain tumors and
    neuroblastomas

         Summary:
    During embryonic development, NTN1 as signaling molecule
    affects the following cells: Embryonic Dopaminergic Neurons in Ventral Tegmental Area, Embryonic Dopaminergic Neurons in Substantia Nigra pars Compacta (see all 3).

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10102268
         
    NTN1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NTN1:
     Decreased G3BP1 protein expres 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ntn1):
     behavior/neurological  cellular  endocrine/exocrine gland  hearing/vestibular/ear  integument 
     mortality/aging  nervous system 

    NTN1 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NTN1 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    PKA Signaling0.56
    cAMP Pathway0.77
    2Axon guidance
    Axon guidance0.69
    Developmental Biology0.69
    3Netrin-1 signaling
    DCC mediated attractive signaling0.33
    Netrin-1 signaling0.33
    4Cell-cell junction organization
    Cell-Cell communication0.64
    5Spinal Cord Injury
    Spinal Cord Injury

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NTN1
        Selected targets of Oct-3/4

    1 R&D Systems Pathway for NTN1
        Notch Signaling Pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NTN1
        PKA Signaling
    Guidance Cues and Growth Cone Motility
    Netrin Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA

    2 BioSystems Pathways for NTN1
        Spinal Cord Injury
    Alpha6-Beta4 Integrin Signaling Pathway

    5/8        Reactome Pathways for NTN1 (see all 8)
        Developmental Biology
    DSCAM interactions
    Netrin mediated repulsion signals
    Netrin-1 signaling
    Role of second messengers in netrin-1 signaling


    1         Kegg Pathway  (Kegg details for NTN1):
        Axon guidance


    NTN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NTN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for NTN1 (O956313 ENSP000001732294) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEO1Q928593, ENSP000002619084I2D: score=1 STRING: ENSP00000261908
    UNC5AQ6ZN443, ENSP000003327374I2D: score=1 STRING: ENSP00000332737
    DCCP431463, ENSP000003891404I2D: score=4 STRING: ENSP00000389140
    UNC5CO951853, ENSP000004060224I2D: score=1 STRING: ENSP00000406022
    ADORA2BP292753, ENSP000003045014I2D: score=1 STRING: ENSP00000304501
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006915apoptotic process IEA--
    GO:0007409axonogenesis ----
    GO:0007411axon guidance TAS--
    GO:0008284positive regulation of cell proliferation IEA--

    NTN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NTN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for NTN1 (NET1)

    9 Novoseek inferred chemical compound relationships for NTN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alar 32.1 1 8982157 (1)
    matrigel 22 2 18461079 (1), 19570425 (1), 17459228 (1)
    heparan sulfate 9.78 1 9341129 (1)
    tyrosine 5.28 6 18253061 (2), 15494732 (1), 16321979 (1), 18616430 (1) (see all 5)
    cyclic amp 5.17 2 12352982 (2)
    cholesterol 0 1 15066264 (1)
    lipid 0 5 18616430 (2), 15066264 (1)
    calcium 0 9 10638760 (4), 16014732 (2), 19650914 (1)
    heparin 0 3 9341129 (1), 10799289 (1)

    Search CenterWatch for drugs/clinical trials and news about NTN1 / NET1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NTN1 gene: 
    NM_004822.2  

    Unigene Cluster for NTN1:

    Netrin 1
    Hs.660885  [show with all ESTs]
    Unigene Representative Sequence: NM_004822
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000173229(uc002glw.4) ENST00000436734 ENST00000538852 ENST00000546090

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    Additional mRNA sequence: 

    BC092429.1 GU727649.1 U75586.1 

    3 DOTS entries:

    DT.406274  DT.91691298  DT.75185888 

    6 AceView cDNA sequences:

    BM924774 U75586 BX109597 NM_004822 AI634709 BF033805 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTN1 expression in normal human tissues (normalized intensities)      NTN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGAACTAA
    NTN1 Expression
    About this image


    NTN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Early Caudal Floor Plate Cells Diencephalic Floor Plate
             Globus Pallidus
             Human Hippocampal Astrocytes   
             Septum   
     
     Neural Tube (Nervous System)    fully expand to see all 12 entries
             Late Floor Plate Cells Mesencephalic Floor Plate
             Telencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             visceral organ/metanephros/renal cortex   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

    See NTN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTN1

    SOURCE GeneReport for Unigene cluster: Hs.660885

    UniProtKB/Swiss-Prot: NET1_HUMAN, O95631
    Tissue specificity: Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon,
    liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein
    level)

        SABiosciences Expression via Pathway-Focused PCR Array including NTN1: 
              Neurogenesis in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTN1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NTN1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntn11 , 5 netrin 11, 5 92.55(n)1
    99.17(a)1
      11 (41.45 cM)5
    182081  NM_008744.21  NP_032770.21 
     682093645 
    chicken
    (Gallus gallus)
    Aves NTN11 netrin 1 86.86(n)
    88.59(a)
      396389  NM_205419.1  NP_990750.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTN16
    NTN56
    Uncharacterized protein
    81(a)
    50(a)
    1 ↔ 1
    possible ortholog
    2(105387248-105536162)
    GL343279.1(1053114-1093318)
    African clawed frog
    (Xenopus laevis)
    Amphibia ntn1-A2 netrin 1 76.21(n)    AF033341.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntn12 netrin 1 78.75(n)   30192  AF017420.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta NetA3
    NetB1
    axon guidance3
    Netrin-B1
    51(a)
    (best of 2)3
    59.87(n)1
    56.51(a)1
      324001  NM_001169282.11  NP_001162753.11 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-61 , 3 Expression: P lineage, sheath_cells,
    head, neurons, more3
    Protein UNC-61
    51(a)3
    54.4(n)1
    54.23(a)1
      X(6925001-6931889)3
    1809611  NM_076764.21  NP_509165.11 


    ENSEMBL Gene Tree for NTN1 (if available)
    TreeFam Gene Tree for NTN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTN1 gene
    LAMC12  LAMC22  NTN32  NTN42  LAMB32  NTN52  LAMC32  NTNG12  
    USH2A2  NTNG22  LAMB42  LAMB22  LAMB12  
    10 SIMAP similar genes for NTN1 using alignment to 2 protein entries:     NET1_HUMAN (see all proteins):
    NTN3    LAMC3    LAMA3    LAMB4    NTNG1    LAMA5
    LAMA1    LAMB1    NTN5    unknown

    NTN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5142 SNPs in NTN1 are shown (see all 5142)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0142804
    ----see VAR_0142802 K E mis40--------
    VAR_0142794
    ----see VAR_0142792 R H mis40--------
    rs790275541,2
    C,F--8922897(+) CTATAA/CTATTC 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs763535471,2
    F--8923029(+) ACCCAG/CGTACC 1 -- us2k13Minor allele frequency- C:0.05CSA WA 120
    rs1923392581,2
    --8923102(+) CAGGTC/TACCAT 1 -- us2k10--------
    rs1411797581,2
    --8923114(+) GTTAAC/TCATTT 1 -- us2k10--------
    rs1450082381,2
    C--8923195(+) GAAATC/TCTTTC 1 -- us2k10--------
    rs1483123811,2
    --8923204(+) TCTGCC/TACAAG 1 -- us2k10--------
    rs1414729471,2
    --8923244(+) AGTGTA/GGTAAA 1 -- us2k10--------
    rs1504398281,2
    C--8923289(+) GGGTAA/GGAAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NTN1 (8924859 - 9147317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for NTN1 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1003228CNV Deletion20482838
    esv2715627CNV Deletion23290073
    esv2715625CNV Deletion23290073
    esv2715630CNV Deletion23290073
    esv2715626CNV Deletion23290073
    esv2675061CNV Deletion23128226
    esv2670723CNV Deletion23128226
    esv2715628CNV Deletion23290073
    nsv1971CNV Insertion18451855
    esv25265CNV Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601614    OMIM disorders: --

    20/27 diseases for NTN1 (see all 27):    About MalaCards
    epididymitis    cleft palate    eclampsia    cleft lip
    pre-eclampsia    colorectal cancer    osteoarthritis    down syndrome
    inflammatory bowel disease    ischemia    neuroblastoma    glioblastoma
    hypoxia    rheumatoid arthritis    colon cancer    retinitis
    arthritis    cervicitis    melanoma    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for NTN1:
    Colorectal cancer

    NTN1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for NTN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 69.6 41 19721007 (3), 19858080 (2), 15811950 (1), 15956977 (1) (see all 28)
    colorectal carcinoma 42.1 3 17549567 (1), 20431009 (1), 16762451 (1)
    cancer 11.5 11 17334389 (3), 15491747 (2), 19543238 (1), 19934758 (1) (see all 7)
    tumors 0.621 35 18353983 (4), 19543238 (3), 17549567 (3), 18922894 (3) (see all 10)
    neovascularization 0 2 18461079 (2)

    Genetic Association Database (GAD): NTN1
    Human Genome Epidemiology (HuGE) Navigator: NTN1 (1 document)

    Export disorders for NTN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTN1 gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with NTN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. (PubMed id 9950216)1, 2, 3, 9 Meyerhardt J.A.... Fearon E.R. (1999)
    2. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (2010)
    3. DSCAM functions as a netrin receptor in commissural axon pathfinding. (PubMed id 19196994)1, 2 Liu G.... Wu J.Y. (2009)
    4. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. (PubMed id 15343335)1, 2 Mazelin L.... Mehlen P. (2004)
    5. Interference with netrin-1 and tumor cell death in non-small cell lung cancer. (PubMed id 19211441)1, 9 Delloye-Bourgeois C....Bernet A. (2009)
    6. Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1. (PubMed id 18653556)1, 9 Moore S.W....Kennedy T.E. (2008)
    7. Netrin-1 inhibits sprouting angiogenesis in developing avian embryos. (PubMed id 18439993)1, 9 Bouvree K....Pardanaud L. (2008)
    8. Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor. (PubMed id 18922894)1, 9 Roperch J.P....Gespach C. (2008)
    9. Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis. (PubMed id 15491747)1, 9 Kato H.D....Wake N. (2004)
    10. Netrin-1 dampens pulmonary inflammation during acute lung injury. (PubMed id 20075388)1, 9 Mirakaj V....Rosenberger P. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9423 HGNC: 8029 AceView: NTN1 Ensembl:ENSG00000065320 euGenes: HUgn9423
    ECgene: NTN1 Kegg: 9423 H-InvDB: NTN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for NTN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NTN1 gene:
    Search GeneIP for patents involving NTN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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