Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NTN1 Gene

Aliases for NTN1 Gene

  • Netrin 1 2 3
  • NTN1L 3 4 6
  • Epididymis Tissue Protein Li 131P 3 4
  • Netrin-1 2 3
  • Netrin 1, Mouse, Homolog Of 3

External Ids for NTN1 Gene

Summaries for NTN1 Gene

Entrez Gene Summary for NTN1 Gene

  • Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTN1 Gene

NTN1 (Netrin 1) is a Protein Coding gene. Diseases associated with NTN1 include semicircular canal dehiscence syndrome. Among its related pathways are L1CAM interactions and Activation of cAMP-Dependent PKA. An important paralog of this gene is NTN3.

UniProtKB/Swiss-Prot for NTN1 Gene

  • Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

Gene Wiki entry for NTN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTN1 Gene

Genomics for NTN1 Gene

Genomic Location for NTN1 Gene

Start:
9,021,542 bp from pter
End:
9,244,000 bp from pter
Size:
222,459 bases
Orientation:
Plus strand

Genomic View for NTN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTN1 Gene

Regulatory Elements for NTN1 Gene

Proteins for NTN1 Gene

  • Protein details for NTN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95631-NET1_HUMAN
    Recommended name:
    Netrin-1
    Protein Accession:
    O95631
    Secondary Accessions:
    • E9KL51

    Protein attributes for NTN1 Gene

    Size:
    604 amino acids
    Molecular mass:
    67748 Da
    Quaternary structure:
    • Binds to its receptors; DCC, DSCAM, UNC5A, UNC5B, UNC5C and probably UNC5D

    Three dimensional structures from OCA and Proteopedia for NTN1 Gene

neXtProt entry for NTN1 Gene

Proteomics data for NTN1 Gene at MOPED

Post-translational modifications for NTN1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn95, Asn116, Asn131, Asn417, Thr460, and Thr461

Other Protein References for NTN1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NTN1 Gene

Domains for NTN1 Gene

Gene Families for NTN1 Gene

HGNC:

Suggested Antigen Peptide Sequences for NTN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95631

UniProtKB/Swiss-Prot:

NET1_HUMAN
Domain:
  • Contains 3 laminin EGF-like domains.:
    • O95631
  • Contains 1 laminin N-terminal domain.:
    • O95631
  • Contains 1 NTR domain.:
    • O95631
genes like me logo Genes that share domains with NTN1: view

Function for NTN1 Gene

Molecular function for NTN1 Gene

GENATLAS Biochemistry: netrin 1,axon outgrow-promoting protein with homology to chicken ntn and C elegans UNC-6,ubiquitously expressed,interacting with DCC,mediated by cytoplasmic Ca2+ signals,markedly reduced in brain tumors and neuroblastomas
UniProtKB/Swiss-Prot Function: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

Gene Ontology (GO) - Molecular Function for NTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10102268
genes like me logo Genes that share ontologies with NTN1: view
genes like me logo Genes that share phenotypes with NTN1: view

miRNA for NTN1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NTN1 Gene

Localization for NTN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTN1 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTN1 Gene COMPARTMENTS Subcellular localization image for NTN1 gene
Compartment Confidence
extracellular 4
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005604 basement membrane IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NTN1: view

Pathways for NTN1 Gene

genes like me logo Genes that share pathways with NTN1: view

Gene Ontology (GO) - Biological Process for NTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006915 apoptotic process IEA --
GO:0007409 axonogenesis --
GO:0007411 axon guidance TAS --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with NTN1: view

Compounds for NTN1 Gene

(9) Novoseek inferred chemical compound relationships for NTN1 Gene

Compound -log(P) Hits PubMed IDs
alar 32.1 1
matrigel 22 3
heparan sulfate 9.78 1
tyrosine 5.28 6
cyclic amp 5.17 2
genes like me logo Genes that share compounds with NTN1: view

Transcripts for NTN1 Gene

mRNA/cDNA for NTN1 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NTN1 Gene

Netrin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTN1 Gene

No ASD Table

Relevant External Links for NTN1 Gene

GeneLoc Exon Structure for
NTN1
ECgene alternative splicing isoforms for
NTN1

Expression for NTN1 Gene

mRNA expression in normal human tissues for NTN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTN1 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (7.4), Esophagus - Muscularis (7.1), Heart - Atrial Appendage (6.5), and Artery - Aorta (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NTN1 Gene

SOURCE GeneReport for Unigene cluster for NTN1 Gene Hs.660885

mRNA Expression by UniProt/SwissProt for NTN1 Gene

O95631-NET1_HUMAN
Tissue specificity: Widely expressed in normal adult tissues with highest levels in heart, small intestine, colon, liver and prostate. Reduced expression in brain tumors and neuroblastomas. Expressed in epididymis (at protein level).
genes like me logo Genes that share expressions with NTN1: view

Orthologs for NTN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NTN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTN1 35
  • 99.56 (n)
  • 99.67 (a)
NTN1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NTN1 35
  • 95.74 (n)
  • 99.67 (a)
NTN1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTN1 35
  • 96.58 (n)
  • 99.34 (a)
NTN1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntn1 35
  • 92.55 (n)
  • 99.17 (a)
Ntn1 16
Ntn1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTN1 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NTN1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntn1 35
  • 92.27 (n)
  • 99.01 (a)
chicken
(Gallus gallus)
Aves NTN1 35
  • 87.42 (n)
  • 89.54 (a)
NTN1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTN1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ntn1-A 35
zebrafish
(Danio rerio)
Actinopterygii ntn1 35
ntn1a 35
  • 77.85 (n)
  • 88.98 (a)
ntn1a 36
  • 87 (a)
OneToMany
ntn1b 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000228 35
  • 65.58 (n)
  • 56.16 (a)
fruit fly
(Drosophila melanogaster)
Insecta NetA 36
  • 43 (a)
ManyToMany
NetB 35
  • 61.65 (n)
  • 59.53 (a)
NetB 36
  • 40 (a)
ManyToMany
NetB 37
  • 45 (a)
NetA 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-6 35
  • 54.55 (n)
  • 54.37 (a)
unc-6 36
  • 50 (a)
OneToMany
unc-6 37
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7467 36
  • 37 (a)
ManyToMany
Species with no ortholog for NTN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NTN1 Gene

ENSEMBL:
Gene Tree for NTN1 (if available)
TreeFam:
Gene Tree for NTN1 (if available)

Paralogs for NTN1 Gene

Paralogs for NTN1 Gene

Selected SIMAP similar genes for NTN1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NTN1: view

Variants for NTN1 Gene

Sequence variations from dbSNP and Humsavar for NTN1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs718097 -- 9,212,088(+) AGGCA(A/G)GTAGG intron-variant
rs726598 -- 9,156,171(+) GCAGT(A/G)CCTGT intron-variant
rs733532 -- 9,223,195(+) TTGCA(A/G)TTACT intron-variant
rs734515 -- 9,208,983(-) GCCAG(C/T)GGGAA intron-variant
rs740640 -- 9,170,113(-) TTCCA(C/T)GCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NTN1 Gene

Variant ID Type Subtype PubMed ID
nsv833354 CNV Loss 17160897
nsv827882 CNV Gain 20364138
nsv7289 OTHER Inversion 18451855
nsv516433 CNV Loss 19592680
esv25265 CNV Loss 19812545
nsv833355 CNV Loss 17160897
nsv1971 CNV Insertion 18451855
nsv519212 CNV Gain 19592680
esv2715625 CNV Deletion 23290073
esv1003228 CNV Deletion 20482838
esv2675061 CNV Deletion 23128226
nsv111830 CNV Loss 16902084
nsv907669 CNV Loss 21882294
dgv3058n71 CNV Loss 21882294
nsv519249 CNV Loss 19592680
esv2715626 CNV Deletion 23290073
esv2715627 CNV Deletion 23290073
nsv521247 CNV Loss 19592680
esv2715628 CNV Deletion 23290073
esv2715630 CNV Deletion 23290073
esv2670723 CNV Deletion 23128226

Relevant External Links for NTN1 Gene

HapMap Linkage Disequilibrium report
NTN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTN1 Gene

Disorders for NTN1 Gene

(1) University of Copenhagen DISEASES for NTN1 Gene

(5) Novoseek inferred disease relationships for NTN1 Gene

Disease -log(P) Hits PubMed IDs
colorectal cancer 69.6 31
colorectal carcinoma 42.1 3
cancer 11.5 10
tumors 0.621 25
neovascularization 0 2

Relevant External Links for NTN1

Genetic Association Database (GAD)
NTN1
Human Genome Epidemiology (HuGE) Navigator
NTN1
genes like me logo Genes that share disorders with NTN1: view

No data available for UniProtKB/Swiss-Prot for NTN1 Gene

Publications for NTN1 Gene

  1. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. (PMID: 9950216) Meyerhardt J.A. … Fearon E.R. (Cell Growth Differ. 1999) 2 3 4 23
  2. The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism. (PMID: 12149262) Li X. … Lamarche-Vane N. (J. Biol. Chem. 2002) 3 23
  3. Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. (PMID: 12636918) Srinivasan K. … Hinck L. (Dev. Cell 2003) 3 23
  4. Expression of DCC and netrin-1 in normal human endometrium and its implication in endometrial carcinogenesis. (PMID: 15491747) Kato H.D. … Wake N. (Gynecol. Oncol. 2004) 3 23
  5. DCC association with lipid rafts is required for netrin-1-mediated axon guidance. (PMID: 15811950) HAcrincs Z. … Mehlen P. (J. Cell. Sci. 2005) 3 23

Products for NTN1 Gene

Sources for NTN1 Gene

Back to Top

Content