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Aliases for NTMT1 Gene

Aliases for NTMT1 Gene

  • N-Terminal Xaa-Pro-Lys N-Methyltransferase 1 2 3 5
  • X-Pro-Lys N-Terminal Protein Methyltransferase 1A 3 4
  • Alpha N-Terminal Protein Methyltransferase 1A 3 4
  • Methyltransferase-Like Protein 11A 3 4
  • N-Terminal RCC1 Methyltransferase 3 4
  • METTL11A 3 4
  • C9orf32 3 4
  • NTM1A 3 4
  • NRMT 3 4
  • Chromosome 9 Open Reading Frame 32 2
  • Methyltransferase Like 11A 2
  • EC 2.1.1.244 4
  • AD-003 3
  • HOMT1A 3
  • NRMT1 4

External Ids for NTMT1 Gene

Previous HGNC Symbols for NTMT1 Gene

  • C9orf32
  • METTL11A

Previous GeneCards Identifiers for NTMT1 Gene

  • GC09P132372

Summaries for NTMT1 Gene

Entrez Gene Summary for NTMT1 Gene

  • The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

GeneCards Summary for NTMT1 Gene

NTMT1 (N-Terminal Xaa-Pro-Lys N-Methyltransferase 1) is a Protein Coding gene. Among its related pathways are DNA Damage. GO annotations related to this gene include methyltransferase activity and O-methyltransferase activity. An important paralog of this gene is METTL11B.

UniProtKB/Swiss-Prot for NTMT1 Gene

  • Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTMT1 Gene

Genomics for NTMT1 Gene

Regulatory Elements for NTMT1 Gene

Enhancers for NTMT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NTMT1 on UCSC Golden Path with GeneCards custom track

Promoters for NTMT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NTMT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NTMT1 Gene

Chromosome:
9
Start:
129,608,884 bp from pter
End:
129,636,131 bp from pter
Size:
27,248 bases
Orientation:
Plus strand

Genomic View for NTMT1 Gene

Genes around NTMT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTMT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTMT1 Gene

Proteins for NTMT1 Gene

  • Protein details for NTMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV86-NTM1A_HUMAN
    Recommended name:
    N-terminal Xaa-Pro-Lys N-methyltransferase 1
    Protein Accession:
    Q9BV86
    Secondary Accessions:
    • A8K4J2
    • A8K8G7
    • Q5SZB9
    • Q9UI28

    Protein attributes for NTMT1 Gene

    Size:
    223 amino acids
    Molecular mass:
    25387 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NTMT1 Gene

    Alternative splice isoforms for NTMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTMT1 Gene

Proteomics data for NTMT1 Gene at MOPED

Post-translational modifications for NTMT1 Gene

  • Ubiquitination at Lys 59 and Lys 101
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for NTMT1 (alpha-N-terminal Methyltransferase 1A/METTL11A)
  • Cell Signaling Technology (CST) Antibodies for NTMT1 (METTL11A)

No data available for DME Specific Peptides for NTMT1 Gene

Domains & Families for NTMT1 Gene

Gene Families for NTMT1 Gene

Protein Domains for NTMT1 Gene

Suggested Antigen Peptide Sequences for NTMT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BV86

UniProtKB/Swiss-Prot:

NTM1A_HUMAN :
  • Belongs to the methyltransferase superfamily. NTM1 family.
Family:
  • Belongs to the methyltransferase superfamily. NTM1 family.
genes like me logo Genes that share domains with NTMT1: view

Function for NTMT1 Gene

Molecular function for NTMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein].
UniProtKB/Swiss-Prot CatalyticActivity:
2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein].
UniProtKB/Swiss-Prot Function:
Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Enzyme Numbers (IUBMB) for NTMT1 Gene

Gene Ontology (GO) - Molecular Function for NTMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0071885 N-terminal protein N-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with NTMT1: view

Phenotypes for NTMT1 Gene

genes like me logo Genes that share phenotypes with NTMT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NTMT1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NTMT1 Gene

Localization for NTMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTMT1 Gene

Nucleus. Note=Predominantly nuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTMT1 Gene COMPARTMENTS Subcellular localization image for NTMT1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for NTMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NTMT1: view

Pathways & Interactions for NTMT1 Gene

SuperPathways for NTMT1 Gene

Superpath Contained pathways
1 DNA Damage
genes like me logo Genes that share pathways with NTMT1: view

Pathways by source for NTMT1 Gene

1 Cell Signaling Technology pathway for NTMT1 Gene

Gene Ontology (GO) - Biological Process for NTMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006480 N-terminal protein amino acid methylation IEA --
GO:0007051 spindle organization IMP 20668449
GO:0007059 chromosome segregation IMP 20668449
GO:0018011 N-terminal peptidyl-alanine methylation IBA --
GO:0035573 N-terminal peptidyl-serine trimethylation IDA 20668449
genes like me logo Genes that share ontologies with NTMT1: view

No data available for SIGNOR curated interactions for NTMT1 Gene

Drugs & Compounds for NTMT1 Gene

(2) Drugs for NTMT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with NTMT1: view

Transcripts for NTMT1 Gene

Unigene Clusters for NTMT1 Gene

N-terminal Xaa-Pro-Lys N-methyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTMT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for NTMT1 Gene

GeneLoc Exon Structure for
NTMT1
ECgene alternative splicing isoforms for
NTMT1

Expression for NTMT1 Gene

mRNA expression in normal human tissues for NTMT1 Gene

Protein differential expression in normal tissues from HIPED for NTMT1 Gene

This gene is overexpressed in Adipocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NTMT1 Gene



SOURCE GeneReport for Unigene cluster for NTMT1 Gene Hs.744027

genes like me logo Genes that share expression patterns with NTMT1: view

Protein tissue co-expression partners for NTMT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NTMT1 Gene

Orthologs for NTMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NTMT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NTMT1 35
  • 87.89 (n)
  • 91.03 (a)
NTMT1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTMT1 35
  • 88.49 (n)
  • 92.38 (a)
NTMT1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntmt1 35
  • 89.99 (n)
  • 94.17 (a)
Ntmt1 16
Ntmt1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NTMT1 35
  • 99.4 (n)
  • 99.55 (a)
METTL11A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntmt1 35
  • 88.79 (n)
  • 94.17 (a)
oppossum
(Monodelphis domestica)
Mammalia NTMT1 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves METTL11A 35
  • 79.82 (n)
  • 82.96 (a)
METTL11A 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntmt1 35
  • 71.15 (n)
  • 74.44 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25348 35
zebrafish
(Danio rerio)
Actinopterygii ntmt1 35
  • 71.15 (n)
  • 71.75 (a)
ntmt1 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010397 35
  • 50.08 (n)
  • 45.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ntmt 35
  • 50.62 (n)
  • 43.06 (a)
Ntmt 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea homt-1 35
  • 45.51 (n)
  • 40.18 (a)
homt-1 36
  • 37 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR615W 35
  • 52.7 (n)
  • 41.9 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02101g 35
  • 49.76 (n)
  • 45.37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAE1 35
  • 47.58 (n)
  • 39.55 (a)
TAE1 36
  • 37 (a)
OneToMany
TAE1 38
TAE1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G44450 35
  • 48.13 (n)
  • 43.93 (a)
rice
(Oryza sativa)
Liliopsida Os03g0780900 35
  • 49.84 (n)
  • 42.38 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01114 35
  • 49.51 (n)
  • 36.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tae1 35
  • 46.76 (n)
  • 40.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for NTMT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTMT1 Gene

ENSEMBL:
Gene Tree for NTMT1 (if available)
TreeFam:
Gene Tree for NTMT1 (if available)

Paralogs for NTMT1 Gene

Paralogs for NTMT1 Gene

(1) SIMAP similar genes for NTMT1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NTMT1: view

Variants for NTMT1 Gene

Sequence variations from dbSNP and Humsavar for NTMT1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1237374 -- 129,608,952(-) GGAAG(C/G)CCCGT utr-variant-5-prime
rs1238143 -- 129,609,054(-) GGTTG(C/T)TGGGG utr-variant-5-prime
rs1310538 -- 129,611,051(-) CTAGG(A/C/G)TTAGT intron-variant
rs1311220 -- 129,609,829(-) GGTCA(C/T)CTGCT intron-variant
rs7856232 -- 129,631,498(+) TTTCT(A/C)GTTCT intron-variant

Variation tolerance for NTMT1 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTMT1 Gene

HapMap Linkage Disequilibrium report
NTMT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NTMT1 Gene

Disorders for NTMT1 Gene

Relevant External Links for NTMT1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NTMT1

No disorders were found for NTMT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NTMT1 Gene

Publications for NTMT1 Gene

  1. Identification of protein N-terminal methyltransferases in yeast and humans. (PMID: 20481588) Webb K.J. … Clarke S.G. (Biochemistry 2010) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Molecular basis for histone N-terminal methylation by NRMT1. (PMID: 26543159) Wu R. … Li H. (Genes Dev. 2015) 3

Products for NTMT1 Gene

Sources for NTMT1 Gene

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