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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTMT1 Gene

protein-coding   GIFtS: 45
GCID: GC09P132372

N-Terminal Xaa-Pro-Lys N-Methyltransferase 1

(Previous names: chromosome 9 open reading frame 32, methyltransferase like...)
(Previous symbols: C9orf32, METTL11A)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
N-Terminal Xaa-Pro-Lys N-Methyltransferase 11 2     NTM1A2 3
C9orf321 2 3     N-Terminal RCC1 Methyltransferase2 3
METTL11A1 2 3     X-Pro-Lys N-Terminal Protein Methyltransferase 1A2 3
Methyltransferase Like 11A1 2     Chromosome 9 Open Reading Frame 321
Alpha N-Terminal Protein Methyltransferase 1A2 3     AD-0032
Methyltransferase-Like Protein 11A2 3     HOMT1A2
NRMT2 3     EC 2.1.1.2443

External Ids:    HGNC: 233731   Entrez Gene: 289892   Ensembl: ENSG000001483357   OMIM: 6135605   UniProtKB: Q9BV863   

Export aliases for NTMT1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTMT1 Gene:
The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange
factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other
protein targets such as SET (MIM 600960) and RB (MIM 180200).(supplied by OMIM, Nov 2010)

GeneCards Summary for NTMT1 Gene: 
NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1) is a protein-coding gene. Diseases associated with NTMT1 include retinoblastoma. GO annotations related to this gene include protein methyltransferase activity. An important paralog of this gene is METTL11B.

UniProtKB/Swiss-Prot: NTM1A_HUMAN, Q9BV86
Function: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal
motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or
tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or
di-methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3,
RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome
segregation via its action on RCC1




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NTMT1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTMT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NTMT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTMT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.2

NTMT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTMT1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P132372:  view genomic region     (about GC identifiers)

Start:
132,371,163 bp from pter      End:
132,398,209 bp from pter
Size:
27,047 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NTM1A_HUMAN, Q9BV86 (See protein sequence)
Recommended Name: N-terminal Xaa-Pro-Lys N-methyltransferase 1  
Size: 223 amino acids; 25387 Da
Subcellular location: Nucleus. Note=Predominantly nuclear
1 PDB 3D structure from and Proteopedia for NTMT1:
2EX4 (3D)    
Secondary accessions: A8K4J2 A8K8G7 Q5SZB9 Q9UI28
Alternative splicing: 2 isoforms:  Q9BV86-1   Q9BV86-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NTMT1: NX_Q9BV86

Explore proteomics data for NTMT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BV86

  • NTMT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NTMT1 Protein Expression
    REFSEQ proteins: NP_054783.2  
    ENSEMBL proteins: 
     ENSP00000361564   ENSP00000361561   ENSP00000473916   ENSP00000474445   ENSP00000473900  
     ENSP00000361559   ENSP00000361558  

    Human Recombinant Protein Products for NTMT1: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene MassSpec for NTMT1 
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    Novus Biologicals NTMT1 Protein
    Novus Biologicals NTMT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    NTMT1 for ontologies           About GeneDecksing



    NTMT1 Antibody Products: 
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    Abcam antibodies for NTMT1
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    LSBio Antibodies in human, mouse, rat for NTMT1 

    Assay Products for NTMT1: 
    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008576 DUF858_MeTrfase_lik

    Graphical View of Domain Structure for InterPro Entry Q9BV86

    ProtoNet protein and cluster: Q9BV86

    1 Blocks protein domain: IPB013216 Methyltransferase type 11

    UniProtKB/Swiss-Prot: NTM1A_HUMAN, Q9BV86
    Similarity: Belongs to the methyltransferase superfamily. NTM1 family


    NTMT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTM1A_HUMAN, Q9BV86
    Function: Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal
    motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or
    tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or
    di-methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3,
    RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome
    segregation via its action on RCC1
    Catalytic activity: 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine +
    N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein]
    Catalytic activity: 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl-L-homocysteine +
    N-terminal-N,N-dimethyl-N-PPK-[protein]

         Enzyme Number (IUBMB): EC 2.1.1.2441

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity ----
    GO:0008171O-methyltransferase activity ----
    GO:0008276protein methyltransferase activity IDA--
         
    NTMT1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NTMT1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTMT1 
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    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTMT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NTMT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for NTMT1 (Q9BV861, 3 ENSP000003615584) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL9P329693, ENSP000003460224I2D: score=1 STRING: ENSP00000346022
    RPL9P7P329693I2D: score=1 
    RPL9P8P329693I2D: score=1 
    RPL9P9P329693I2D: score=1 
    DIS3Q9Y2L11, 3, ENSP000003669974EBI-373016,EBI-373539 I2D: score=1 STRING: ENSP00000366997
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007051spindle organization IMP--
    GO:0007059chromosome segregation IMP--
    GO:0008152metabolic process ----
    GO:0018012N-terminal peptidyl-alanine trimethylation IEA--
    GO:0018016N-terminal peptidyl-proline dimethylation IDA--

    NTMT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NTMT1 (NTM1A)

    Search CenterWatch for drugs/clinical trials and news about NTMT1 / NTM1A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NTMT1 gene: 
    NM_014064.2  

    Unigene Cluster for NTMT1:

    N-terminal Xaa-Pro-Lys N-methyltransferase 1
    Hs.744027  [show with all ESTs]
    Unigene Representative Sequence: AK298840
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372486 ENST00000372483(uc004byd.1 uc011mbs.1 uc010myw.1)
    ENST00000481189 ENST00000459968 ENST00000482347 ENST00000372481 ENST00000372480
    ENST00000486391
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for NTMT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTMT1
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                         Customized lentivirus expression plasmids for stable overexpression of NTMT1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTMT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTMT1

    Additional mRNA sequence: 

    AF110776.1 AK290957.1 AK292332.1 AK298840.1 AK307056.1 AK313829.1 BC001396.2 BC033234.1 

    14 DOTS entries:

    DT.446030  DT.87012862  DT.91889663  DT.92453551  DT.95255586  DT.40132163  DT.75103880  DT.92453539 
    DT.100817843  DT.101985432  DT.95159180  DT.95159200  DT.97859447  DT.100751546 

    24/158 AceView cDNA sequences (see all 158):

    BM712495 BM909502 BU682643 BM927413 AA974686 BM887977 BQ083423 CF529599 
    BM009597 BM554138 AJ572109 F29109 AA084995 BU186604 BQ940794 BM916567 
    BM781855 BQ689083 AW157326 CA421004 AI147433 BM915354 BI083998 D12039 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for NTMT1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
    SP1:              -     -                 -                     
    SP2:              -     -           -     -                     
    SP3:                    -                 -                     
    SP4:              -     -                                       
    SP5:                                                            


    ECgene alternative splicing isoforms for NTMT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTMT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NTMT1 Expression
    About this image


    See NTMT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTMT1

    SOURCE GeneReport for Unigene cluster: Hs.744027
        SABiosciences Custom PCR Arrays for NTMT1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTMT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NTMT1 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntmt11 , 5 methyltransferase like 11A5
    N-terminal Xaa-Pro-Lys N-methyltransferase 11
    89.99(n)1
    94.17(a)1
      2 (21.74 cM)5
    666171  NM_170592.21  NP_733480.11 
     308078265 
    chicken
    (Gallus gallus)
    Aves METTL11A1 methyltransferase like 11A 80.12(n)
    82.96(a)
      425539  XM_003642297.1  XP_003642345.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.253482 Xenopus laevis transcribed sequence with moderate similarity more 72.69(n)    BX848741.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570453622   -- 72.34(n)    57045362 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG16751 CG1675 50.77(n)
    43.06(a)
      36022  NM_136684.2  NP_610528.1 
    worm
    (Caenorhabditis elegans)
    Secernentea homt-11 Protein HOMT-1 45.51(n)
    40.18(a)
      171590  NM_058260.3  NP_490660.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAE1(YBR261C)4
    TAE11
    AdoMet-dependent proline methyltransferase; catalyzes more4
    Tae1p1
    47.27(n)1
    39.55(a)1
      2(735530-734832)4
    8525641, 4  NP_009820.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G444501 methyltransferase 48.27(n)
    44.34(a)
      834472  NM_123812.4  NP_199258.3 
    rice
    (Oryza sativa)
    Liliopsida Os03g07809001 hypothetical protein 49.84(n)
    42.38(a)
      4334312  NM_001057989.1  NP_001051454.1 


    ENSEMBL Gene Tree for NTMT1 (if available)
    TreeFam Gene Tree for NTMT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTMT1 gene
    METTL11B2  
    1 SIMAP similar gene for NTMT1 using alignment to 1 protein entry:     NTM1A_HUMAN:
    METTL11B

    NTMT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/201 SNPs in NTMT1 are shown (see all 201)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753651901,2
    C--132386442(+) CTATGC/TGCTAG 1 -- us2k10--------
    rs1463311531,2
    --132386487(+) TCAGGG/TAGCCG 1 -- us2k10--------
    rs1842028741,2
    --132386516(+) TTGGAA/GCGTGG 1 -- us2k10--------
    rs1888282511,2
    --132386525(+) GGCTGC/TGGGGA 1 -- us2k10--------
    rs1815356261,2
    --132386539(+) GGCTTA/GCTCTT 1 -- us2k10--------
    rs1853117261,2
    --132386583(+) TAGGCA/CTACAG 1 -- us2k10--------
    rs1905091141,2
    --132386726(+) CAGTTA/GTGACC 1 -- us2k10--------
    rs45094421,2
    C,F,H--132386835(+) TTTCAG/ACACAT 1 -- us2k132Minor allele frequency- A:0.06NA NS EA WA CSA 2906
    rs1382429641,2
    --132386844(+) ATTTAA/GAGCAA 1 -- us2k10--------
    rs70376861,2
    C,F,H--132386966(+) agcaaT/Cggcgc 1 -- us2k14Minor allele frequency- C:0.00NS EA 416

    HapMap Linkage Disequilibrium report for NTMT1 (132371163 - 132398209 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NTMT1: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613560    OMIM disorders: --

    2 diseases for NTMT1:    About MalaCards
    retinoblastoma    


    NTMT1 for disorders           About GeneDecksing


    Export disorders for NTMT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTMT1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with NTMT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of protein N-terminal methyltransferases in yeast and humans. (PubMed id 20481588)1, 2, 3 Webb K.J.... Clarke S.G. (2010)
    2. NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. (PubMed id 20668449)1, 2 Tooley C.E.... Macara I.G. (2010)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Substrate specificity of mammalian N-terminal a-amino methyltransferase NRMT. (PubMed id 22769851)1 Petkowski J.J....Macara I.G. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28989 HGNC: 23373 AceView: AD-003 Ensembl:ENSG00000148335 euGenes: HUgn28989
    ECgene: NTMT1 H-InvDB: NTMT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTMT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NTMT1 gene:
    Search GeneIP for patents involving NTMT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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