Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NTMT1 Gene

Aliases for NTMT1 Gene

  • N-Terminal Xaa-Pro-Lys N-Methyltransferase 1 2 3
  • X-Pro-Lys N-Terminal Protein Methyltransferase 1A 3 4
  • Alpha N-Terminal Protein Methyltransferase 1A 3 4
  • Methyltransferase-Like Protein 11A 3 4
  • N-Terminal RCC1 Methyltransferase 3 4
  • METTL11A 3 4
  • C9orf32 3 4
  • NTM1A 3 4
  • NRMT 3 4
  • Chromosome 9 Open Reading Frame 32 2
  • Methyltransferase Like 11A 2
  • EC 2.1.1.244 4
  • AD-003 3
  • HOMT1A 3
  • NRMT1 4

External Ids for NTMT1 Gene

Previous Symbols for NTMT1 Gene

  • C9orf32
  • METTL11A

Summaries for NTMT1 Gene

Entrez Gene Summary for NTMT1 Gene

  • The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]

GeneCards Summary for NTMT1 Gene

NTMT1 (N-Terminal Xaa-Pro-Lys N-Methyltransferase 1) is a Protein Coding gene. GO annotations related to this gene include protein methyltransferase activity. An important paralog of this gene is METTL11B.

UniProtKB/Swiss-Prot for NTMT1 Gene

  • Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTMT1 Gene

Genomics for NTMT1 Gene

Genomic Location for NTMT1 Gene

Start:
129,608,884 bp from pter
End:
129,636,131 bp from pter
Size:
27,248 bases
Orientation:
Plus strand

Genomic View for NTMT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTMT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTMT1 Gene

No data available for Regulatory Elements for NTMT1 Gene

Proteins for NTMT1 Gene

  • Protein details for NTMT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BV86-NTM1A_HUMAN
    Recommended name:
    N-terminal Xaa-Pro-Lys N-methyltransferase 1
    Protein Accession:
    Q9BV86
    Secondary Accessions:
    • A8K4J2
    • A8K8G7
    • Q5SZB9
    • Q9UI28

    Protein attributes for NTMT1 Gene

    Size:
    223 amino acids
    Molecular mass:
    25387 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NTMT1 Gene

    Alternative splice isoforms for NTMT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTMT1 Gene

Proteomics data for NTMT1 Gene at MOPED

Post-translational modifications for NTMT1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys10, Lys59, and Lys101

No data available for DME Specific Peptides for NTMT1 Gene

Domains for NTMT1 Gene

Protein Domains for NTMT1 Gene

UniProtKB/Swiss-Prot:

NTM1A_HUMAN
Family:
  • Belongs to the methyltransferase superfamily. NTM1 family.:
    • Q9BV86
genes like me logo Genes that share domains with NTMT1: view

No data available for Gene Families for NTMT1 Gene

Function for NTMT1 Gene

Molecular function for NTMT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N-(A,S)PK-[protein]
UniProtKB/Swiss-Prot CatalyticActivity: 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl-L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein]
UniProtKB/Swiss-Prot Function: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1.

Enzyme Numbers (IUBMB) for NTMT1 Gene

Gene Ontology (GO) - Molecular Function for NTMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity --
GO:0008171 O-methyltransferase activity --
GO:0008276 protein methyltransferase activity IDA 20481588
GO:0071885 N-terminal protein N-methyltransferase activity IBA --
genes like me logo Genes that share ontologies with NTMT1: view

miRNA for NTMT1 Gene

miRTarBase miRNAs that target NTMT1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NTMT1 Gene

Localization for NTMT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTMT1 Gene

Nucleus. Note=Predominantly nuclear.

Gene Ontology (GO) - Cellular Components for NTMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20668449
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with NTMT1: view

Pathways for NTMT1 Gene

SuperPathways for NTMT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NTMT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007051 spindle organization IMP 20668449
GO:0007059 chromosome segregation IMP 20668449
GO:0008152 metabolic process --
GO:0018011 N-terminal peptidyl-alanine methylation IBA --
GO:0018012 N-terminal peptidyl-alanine trimethylation IEA --
genes like me logo Genes that share ontologies with NTMT1: view

No data available for Pathways by source for NTMT1 Gene

Transcripts for NTMT1 Gene

Unigene Clusters for NTMT1 Gene

N-terminal Xaa-Pro-Lys N-methyltransferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTMT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for NTMT1 Gene

GeneLoc Exon Structure for
NTMT1
ECgene alternative splicing isoforms for
NTMT1

Expression for NTMT1 Gene

mRNA expression in normal human tissues for NTMT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NTMT1 Gene

SOURCE GeneReport for Unigene cluster for NTMT1 Gene Hs.744027

genes like me logo Genes that share expressions with NTMT1: view

Orthologs for NTMT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NTMT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia METTL11A 37
  • 100 (a)
OneToOne
NTMT1 36
  • 99.4 (n)
  • 99.55 (a)
cow
(Bos Taurus)
Mammalia NTMT1 36
  • 87.89 (n)
  • 91.03 (a)
NTMT1 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTMT1 36
  • 88.49 (n)
  • 92.38 (a)
NTMT1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntmt1 36
  • 89.99 (n)
  • 94.17 (a)
Ntmt1 16
Ntmt1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTMT1 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntmt1 36
  • 88.79 (n)
  • 94.17 (a)
chicken
(Gallus gallus)
Aves METTL11A 36
  • 79.82 (n)
  • 82.96 (a)
METTL11A 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25348 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ntmt1 36
  • 71.15 (n)
  • 74.44 (a)
zebrafish
(Danio rerio)
Actinopterygii ntmt1 36
  • 71.15 (n)
  • 71.75 (a)
ntmt1 37
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010397 36
  • 50.08 (n)
  • 45.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ntmt 36
  • 50.62 (n)
  • 43.06 (a)
Ntmt 37
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea homt-1 36
  • 45.51 (n)
  • 40.18 (a)
homt-1 37
  • 37 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR615W 36
  • 52.7 (n)
  • 41.9 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAE1 36
  • 47.58 (n)
  • 39.55 (a)
TAE1 37
  • 37 (a)
OneToMany
TAE1 39
TAE1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02101g 36
  • 49.76 (n)
  • 45.37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G44450 36
  • 48.13 (n)
  • 43.93 (a)
rice
(Oryza sativa)
Liliopsida Os03g0780900 36
  • 49.84 (n)
  • 42.38 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01114 36
  • 49.51 (n)
  • 36.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tae1 36
  • 46.76 (n)
  • 40.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToMany
Species with no ortholog for NTMT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTMT1 Gene

ENSEMBL:
Gene Tree for NTMT1 (if available)
TreeFam:
Gene Tree for NTMT1 (if available)

Paralogs for NTMT1 Gene

Paralogs for NTMT1 Gene

Selected SIMAP similar genes for NTMT1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NTMT1: view

Variants for NTMT1 Gene

Sequence variations from dbSNP and Humsavar for NTMT1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1237374 -- 129,608,952(-) GGAAG(C/G)CCCGT utr-variant-5-prime
rs1238143 -- 129,609,054(-) GGTTG(C/T)TGGGG utr-variant-5-prime
rs1310538 -- 129,611,051(-) CTAGG(C/G)TTAGT intron-variant
rs1311220 -- 129,609,829(-) GGTCA(C/T)CTGCT intron-variant
rs1861782 -- 129,627,960(-) CCAAG(A/G)TGTTC intron-variant

Relevant External Links for NTMT1 Gene

HapMap Linkage Disequilibrium report
NTMT1

No data available for Structural Variations from Database of Genomic Variants (DGV) for NTMT1 Gene

Disorders for NTMT1 Gene

No disorders were found for NTMT1 Gene.

No data available for UniProtKB/Swiss-Prot for NTMT1 Gene

Publications for NTMT1 Gene

  1. Identification of protein N-terminal methyltransferases in yeast and humans. (PMID: 20481588) Webb K.J. … Clarke S.G. (Biochemistry 2010) 2 3 4
  2. NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. (PMID: 20668449) Tooley C.E. … Macara I.G. (Nature 2010) 3 4
  3. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for NTMT1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate NTMT1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for NTMT1
    • Block miRNA regulation of NTMT1 using miScript Target Protectors

    Sources for NTMT1 Gene

    Back to Top

    Content