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Aliases for NTM Gene

Aliases for NTM Gene

  • Neurotrimin 2 3 2
  • IgLON Family Member 2 2 3 4
  • IGLON2 3 4
  • HNT 3 4
  • NTRI 3
  • NT 4

External Ids for NTM Gene

Previous GeneCards Identifiers for NTM Gene

  • GC11P130746
  • GC11P131240
  • GC11P127736

Summaries for NTM Gene

Entrez Gene Summary for NTM Gene

  • This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

GeneCards Summary for NTM Gene

NTM (Neurotrimin) is a Protein Coding gene. An important paralog of this gene is LSAMP.

UniProtKB/Swiss-Prot for NTM Gene

  • Neural cell adhesion molecule

Gene Wiki entry for NTM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTM Gene

Genomics for NTM Gene

Regulatory Elements for NTM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NTM Gene

131,370,361 bp from pter
132,336,822 bp from pter
966,462 bases
Plus strand

Genomic View for NTM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTM Gene

Proteins for NTM Gene

  • Protein details for NTM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A0MTT2
    • Q6UXJ3
    • Q86VJ9

    Protein attributes for NTM Gene

    344 amino acids
    Molecular mass:
    37971 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NTM Gene


neXtProt entry for NTM Gene

Proteomics data for NTM Gene at MOPED

Post-translational modifications for NTM Gene

  • Glycosylation at Asn 44, Asn 70, Asn 152, Asn 284, Asn 292, Asn 305, and Asn 321
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for NTM Gene

Domains & Families for NTM Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. IgLON family.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. IgLON family.
genes like me logo Genes that share domains with NTM: view

Function for NTM Gene

Molecular function for NTM Gene

UniProtKB/Swiss-Prot Function:
Neural cell adhesion molecule

Gene Ontology (GO) - Molecular Function for NTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with NTM: view

Phenotypes for NTM Gene

GenomeRNAi human phenotypes for NTM:
genes like me logo Genes that share phenotypes with NTM: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NTM

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for NTM Gene

Localization for NTM Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTM Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for NTM Gene COMPARTMENTS Subcellular localization image for NTM gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for NTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0005911 cell-cell junction IBA --
GO:0009986 cell surface IBA --
GO:0031225 anchored component of membrane IEA --
GO:0043005 neuron projection IBA --
genes like me logo Genes that share ontologies with NTM: view

Pathways & Interactions for NTM Gene

SuperPathways for NTM Gene

No Data Available

Gene Ontology (GO) - Biological Process for NTM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion NAS 7891157
GO:0008038 neuron recognition TAS 7891157
GO:0016337 single organismal cell-cell adhesion IBA --
GO:0050767 regulation of neurogenesis IBA --
genes like me logo Genes that share ontologies with NTM: view

No data available for Pathways by source and SIGNOR curated interactions for NTM Gene

Drugs & Compounds for NTM Gene

(1) Drugs for NTM Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Clarithromycin Approved Pharma 230
genes like me logo Genes that share compounds with NTM: view

Transcripts for NTM Gene

Unigene Clusters for NTM Gene

Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NTM

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTM Gene

No ASD Table

Relevant External Links for NTM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NTM Gene

mRNA expression in normal human tissues for NTM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTM Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.9), Brain - Cerebellum (x5.7), Brain - Cortex (x4.1), and Brain - Frontal Cortex (BA9) (x4.1).

Protein differential expression in normal tissues from HIPED for NTM Gene

This gene is overexpressed in Cerebrospinal fluid (27.6), Fetal Brain (16.5), Frontal cortex (9.6), and Retina (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NTM Gene

SOURCE GeneReport for Unigene cluster for NTM Gene Hs.504352

genes like me logo Genes that share expression patterns with NTM: view

Protein tissue co-expression partners for NTM Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for NTM Gene

Orthologs for NTM Gene

This gene was present in the common ancestor of animals.

Orthologs for NTM Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NTM 35
  • 91.08 (n)
  • 98.78 (a)
NTM 36
  • 98 (a)
(Canis familiaris)
Mammalia NTM 35
  • 92.77 (n)
  • 98.31 (a)
NTM 36
  • 99 (a)
(Mus musculus)
Mammalia Ntm 35
  • 87.69 (n)
  • 94.29 (a)
Ntm 16
Ntm 36
  • 91 (a)
(Pan troglodytes)
Mammalia NTM 35
  • 99.11 (n)
  • 99 (a)
NTM 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Ntm 35
  • 90.99 (n)
  • 97.67 (a)
(Monodelphis domestica)
Mammalia NTM 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia NTM 36
  • 89 (a)
(Gallus gallus)
Aves NTM 35
  • 78.93 (n)
  • 82.07 (a)
NTM 36
  • 74 (a)
(Anolis carolinensis)
Reptilia NTM 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ntm 35
  • 71.37 (n)
  • 74.17 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26284 35
(Danio rerio)
Actinopterygii opcml 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009965 35
  • 44.66 (n)
  • 31.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31708 35
  • 47.86 (n)
  • 35.53 (a)
Ama 36
  • 23 (a)
CG11320 36
  • 24 (a)
CG14010 36
  • 22 (a)
CG14521 36
  • 23 (a)
CG31646 36
  • 17 (a)
CG31708 36
  • 19 (a)
CG31814 36
  • 16 (a)
CG32791 36
  • 17 (a)
CG34353 36
  • 16 (a)
CG34391 36
  • 20 (a)
CG40378 36
  • 24 (a)
CG42343 36
  • 18 (a)
CG42368 36
  • 22 (a)
CG7166 36
  • 17 (a)
klg 36
  • 16 (a)
Lac 36
  • 21 (a)
wrapper 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea rig-5 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for NTM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NTM Gene

Gene Tree for NTM (if available)
Gene Tree for NTM (if available)

Paralogs for NTM Gene

Paralogs for NTM Gene

(6) SIMAP similar genes for NTM Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with NTM: view

Variants for NTM Gene

Sequence variations from dbSNP and Humsavar for NTM Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2706 -- 132,335,612(-) CCGTG(G/T)TGGCA utr-variant-3-prime
rs3345 -- 131,971,675(-) ACATA(C/T)AGata intron-variant
rs7974 -- 132,336,283(-) TAGAA(A/G)ATCAA utr-variant-3-prime
rs8894 -- 132,335,321(-) AAACT(C/T)TTTTC utr-variant-3-prime
rs11634 -- 132,335,500(-) TCCAC(A/G)TGGGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NTM Gene

Variant ID Type Subtype PubMed ID
nsv898465 CNV Gain 21882294
esv1006260 CNV Insertion 20482838
esv2745268 CNV Deletion 23290073
esv269102 CNV Insertion 20981092
esv9451 CNV Gain 19470904
esv268386 CNV Insertion 20981092
esv272292 CNV Insertion 20981092
esv275372 CNV Gain+Loss 21479260
dgv448e1 CNV Complex 17122850
nsv428266 CNV Gain 18775914
nsv519866 CNV Loss 19592680
nsv826135 CNV Loss 20364138
esv2666803 CNV Deletion 23128226
dgv1325n71 CNV Loss 21882294
nsv526844 CNV Gain 19592680
nsv553 CNV Insertion 18451855
esv2745269 CNV Deletion 23290073
esv2745270 CNV Deletion 23290073
esv2517835 CNV Insertion 19546169
esv1144589 CNV Insertion 17803354
esv1243815 CNV Insertion 17803354
nsv499166 CNV Gain 21111241
esv1673449 CNV Insertion 17803354
esv1453063 CNV Deletion 17803354
esv27663 CNV Gain 19812545
nsv821528 CNV Deletion 20802225
esv2745271 CNV Deletion 23290073
nsv898468 CNV Gain 21882294
esv2677132 CNV Deletion 23128226
esv21641 CNV Loss 19812545
nsv510281 CNV Loss 20534489
nsv468898 CNV Gain 19166990
nsv517550 CNV Gain+Loss 19592680
esv2632966 CNV Deletion 19546169
esv2141370 CNV Deletion 18987734
esv2745272 CNV Deletion 23290073
esv2675610 CNV Deletion 23128226
esv1515834 CNV Deletion 17803354
esv2745273 CNV Deletion 23290073
esv2745274 CNV Deletion 23290073
esv1008024 CNV Deletion 20482838
esv2745276 CNV Deletion 23290073
nsv522510 CNV Loss 19592680
nsv554 CNV Insertion 18451855
dgv252n67 CNV Gain 20364138
esv24689 CNV Gain 19812545
nsv513747 CNV Insertion 21212237
nsv898469 CNV Gain 21882294
nsv898470 CNV Loss 21882294
esv25603 CNV Loss 19812545
esv2672347 CNV Deletion 23128226
esv2745277 CNV Deletion 23290073
esv1186595 CNV Deletion 17803354
esv2745278 CNV Deletion 23290073
esv2745279 CNV Deletion 23290073
nsv512244 CNV Loss 21212237
esv2745280 CNV Deletion 23290073
esv2745281 CNV Deletion 23290073
esv1589319 CNV Insertion 17803354
esv2745282 CNV Deletion 23290073
nsv428267 CNV Loss 18775914
nsv832296 CNV Gain 17160897
esv2659747 CNV Deletion 23128226
esv26341 CNV Loss 19812545
esv2745283 CNV Deletion 23290073
nsv556 CNV Loss 18451855
nsv39518 CNV Insertion 16902084
esv2674917 CNV Deletion 23128226
esv2652259 CNV Deletion 19546169
esv1929334 CNV Deletion 18987734
esv2745284 CNV Deletion 23290073
esv2668524 CNV Deletion 23128226
esv8607 CNV Loss 19470904
esv993815 CNV Deletion 20482838

Variation tolerance for NTM Gene

Residual Variation Intolerance Score: 22.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 36.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTM Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTM Gene

Disorders for NTM Gene

Relevant External Links for NTM

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NTM: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NTM Gene

Publications for NTM Gene

  1. IgLON cell adhesion molecules regulate synaptogenesis in hippocampal neurons. (PMID: 19711485) Hashimoto T. … Miyata S. (Cell Biochem. Funct. 2009) 23 67
  2. A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. (PMID: 17564960) Liu F. … van Duijn C.M. (Am. J. Hum. Genet. 2007) 23 67
  3. Expression of neurotrimin in the normal and injured adult human spinal cord. (PMID: 16172623) Grijalva I. … Levi A.D. (Spinal Cord 2006) 23 67
  4. Diglons are heterodimeric proteins composed of IgLON subunits, and Diglon-CO inhibits neurite outgrowth from cerebellar granule cells. (PMID: 15265982) Reed J. … Moss D. (J. Cell. Sci. 2004) 23 67
  5. The cloning and preliminarily functional analysis of the human neurotrimin gene. (PMID: 15379248) Liu J. … Yuan J. (Sci. China, C, Life Sci. 2004) 23 67

Products for NTM Gene

Sources for NTM Gene

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