Aliases for NTHL1 Gene
Aliases for NTHL1 Gene
External Ids for NTHL1 Gene
- HGNC: 8028
- Entrez Gene: 4913
- Ensembl: ENSG00000065057
- OMIM: 602656
- UniProtKB: P78549
Previous GeneCards Identifiers for NTHL1 Gene
- GC16M002107
- GC16M002030
- GC16M002031
- GC16M002032
- GC16M002089
- GC16M002014
- GC16M002041
- GC16M002042
- GC16M002052
- GC16M002061
Summaries for NTHL1 Gene
-
The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. [provided by RefSeq, Oct 2008]
GeneCards Summary for NTHL1 Gene
NTHL1 (Nth Like DNA Glycosylase 1) is a Protein Coding gene. Diseases associated with NTHL1 include Familial Adenomatous Polyposis 3 and Periampullary Adenoma. Among its related pathways are Depyrimidination and Telomere C-strand (Lagging Strand) Synthesis. Gene Ontology (GO) annotations related to this gene include double-stranded DNA binding and 4 iron, 4 sulfur cluster binding.
UniProtKB/Swiss-Prot for NTHL1 Gene
-
Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3 to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Additional gene information for NTHL1 Gene
- Monarch Initiative
- Search for NTHL1 at DataMed
- Search for NTHL1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTHL1 Gene
Genomics for NTHL1 Gene
GeneHancer (GH) Regulatory Elements for NTHL1 Gene
Regulatory Element Products
Genomic Locations for NTHL1 Gene
- chr16:2,039,815-2,047,866
- (GRCh38/hg38)
- Size:
- 8,052 bases
- Orientation:
- Minus strand
- chr16:2,089,816-2,097,867
- (GRCh37/hg19)
Genomic View for NTHL1 Gene
- Cytogenetic band:
-
- 16p13.3 by Ensembl
- 16p13.3 by Entrez Gene
- 16p13.3 by HGNC


RefSeq DNA sequence for NTHL1 Gene
Proteins for NTHL1 Gene
-
Protein details for NTHL1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P78549-NTH_HUMAN
- Recommended name:
- Endonuclease III-like protein 1
- Protein Accession:
- P78549
- Q1MVR1
- Q99566
- Q99794
- Q9BPX2
Protein attributes for NTHL1 Gene
- Size:
- 312 amino acids
- Molecular mass:
- 34390 Da
- Cofactor:
- Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
- Quaternary structure:
-
- Interacts with YBX1.
Protein Expression for NTHL1 Gene
Post-translational modifications for NTHL1 Gene
Other Protein References for NTHL1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for NTHL1 (NTH1)
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Abcam antibodies for NTHL1
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Protein Products
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-
Abcam proteins for NTHL1
No data available for DME Specific Peptides for NTHL1 Gene
Domains & Families for NTHL1 Gene
Gene Families for NTHL1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for NTHL1 Gene
Suggested Antigen Peptide Sequences for NTHL1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P78549- Family:
-
- Belongs to the Nth/MutY family.
Function for NTHL1 Gene
Molecular function for NTHL1 Gene
- GENATLAS Biochemistry:
- nth (E coli endonuclease III)-like 1,34.3 kDa,with lyase activity,involved in the excision of damaged pyrimidines
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=371 nM for 5-hydroxy-6-hydrothymine containing duplex oligonucleotides (N-glycosylase activity) {ECO:0000269 PubMed:11380260, ECO:0000269 PubMed:9890904}; KM=1093 nM for 5-hydroxyuracil containing duplex oligonucleotides (N-glycosylase activity) {ECO:0000269 PubMed:11380260, ECO:0000269 PubMed:9890904}; KM=548 nM for 5-hydroxycytosine containing duplex oligonucleotides (N-glycosylase activity) {ECO:0000269 PubMed:11380260, ECO:0000269 PubMed:9890904}; KM=1101 nM for thymine glycol containing duplex oligonucleotides (N-glycosylase activity) {ECO:0000269 PubMed:11380260, ECO:0000269 PubMed:9890904}; KM=718 nM for 5,6-dihydroxycytosine containing duplex oligonucleotides (N-glycosylase activity) {ECO:0000269 PubMed:11380260, ECO:0000269 PubMed:9890904}; KM=0.05 nM for 5-hydroxycytosine-G containing duplex oligonucleotides (N-glycosylase activity) {ECO:0000269 PubMed:11380260, ECO:0000269 PubMed:9890904}; KM=0.2 nM for 5-hydroxycytosine-A containing duplex oligonucleotides (N-glycosylase activity) {ECO:0000269 PubMed:11380260, ECO:0000269 PubMed:9890904};
- UniProtKB/Swiss-Prot CatalyticActivity:
- The C-O-P bond 3 to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3-terminal unsaturated sugar and a product with a terminal 5-phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- APE1 displaces NTHL1 from the N-glycosylase-generated AP site in DNA, thereby increasing the turnover of the DNA N-glycosylase activity. AP lyase activity is stimulated by YBX1.
- UniProtKB/Swiss-Prot Function:
- Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3 to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.
Enzyme Numbers (IUBMB) for NTHL1 Gene
Phenotypes From GWAS Catalog for NTHL1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000703 | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity | TAS | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003690 | double-stranded DNA binding | IDA | 15358233 |
GO:0003824 | catalytic activity | IEA | -- |
GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity | IDA | 8990169 |
Phenotypes for NTHL1 Gene
- MGI mutant phenotypes for NTHL1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for NTHL1:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability ratio
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Decreased influenza A/WSN/33 replication
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased homologous recombination repair frequency
- Decreased viability after sindbis virus (SIN) dsTE12Q infection
- Decreased mitophagy mCherry-Parkin protein expression after carbonyl cyanide m-chlorphenylhydrazone (CCCP) stimulation
- Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization
- Decreased influenza A H1N1 (A/Hamburg/04/2009) virus numbers
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miRNA for NTHL1 Gene
- miRTarBase miRNAs that target NTHL1
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-
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for NTHL1
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No data available for Transcription Factor Targets and HOMER Transcription for NTHL1 Gene
Localization for NTHL1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NTHL1 Gene
- Nucleus. Mitochondrion.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IDA | 12531031 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005739 | mitochondrion | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NTHL1 Gene
Pathways & Interactions for NTHL1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Telomere C-strand (Lagging Strand) Synthesis | ||
2 | Depyrimidination | ||
3 | Chks in Checkpoint Regulation | ||
4 | DNA Double-Strand Break Repair |
.53
|
|
5 | DNA damage_Role of Brca1 and Brca2 in DNA repair |
Pathways by source for NTHL1 Gene
8 Reactome pathways for NTHL1 Gene
1 KEGG pathway for NTHL1 Gene
1 GeneGo (Thomson Reuters) pathway for NTHL1 Gene
1 Qiagen pathway for NTHL1 Gene
Interacting Proteins for NTHL1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006281 | DNA repair | IEA | -- |
GO:0006284 | base-excision repair | IEA | -- |
GO:0006285 | base-excision repair, AP site formation | IDA | 15358233 |
GO:0006296 | nucleotide-excision repair, DNA incision, 5-to lesion | IEA,IDA | 8990169 |
GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
No data available for SIGNOR curated interactions for NTHL1 Gene
Transcripts for NTHL1 Gene
mRNA/cDNA for NTHL1 Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (12) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NTHL1 Gene
CRISPR Products
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Vectors and viruses for KO, Activation, Repression, and more
-
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NTHL1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||||
SP6: |
Expression for NTHL1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NTHL1 Gene
NURSA nuclear receptor signaling pathways regulating expression of NTHL1 Gene:
NTHL1SOURCE GeneReport for Unigene cluster for NTHL1 Gene:
Hs.66196mRNA Expression by UniProt/SwissProt for NTHL1 Gene:
P78549-NTH_HUMANEvidence on tissue expression from TISSUES for NTHL1 Gene
- Liver(4.3)
- Bone marrow(4.2)
- Lung(4.2)
- Spleen(4.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for NTHL1 Gene
- ectoderm
- mesoderm
- integumentary
- reproductive
- skeletal muscle
- breast
- skin
Primer Products
-
OriGene qPCR primer pairs for NTHL1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for NTHL1 Gene
Orthologs for NTHL1 Gene
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | NTHL1 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | NTHL1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | NTHL1 33 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Nthl1 33 |
|
||
mouse (Mus musculus) |
Mammalia | Nthl1 33 16 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | NTHL1 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | NTHL1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | NTHL1 33 |
|
||
CHNTHL1 34 |
|
OneToOne | |||
lizard (Anolis carolinensis) |
Reptilia | NTHL1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | nthl1 33 |
|
||
Str.11448 33 |
|
||||
zebrafish (Danio rerio) |
Actinopterygii | nthl1 33 34 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG9272 35 33 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | nth-1 33 34 |
|
||
R10E4.5 35 |
|
|
|||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NTG1 34 36 |
|
OneToMany | |
NTG2 34 |
|
OneToMany | |||
bread mold (Neurospora crassa) |
Ascomycetes | NCU06654 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | nth1 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.720 34 |
|
OneToOne |
- Species where no ortholog for NTHL1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NTHL1 Gene
No data available for Paralogs for NTHL1 Gene
Variants for NTHL1 Gene
SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1057522105 | likely-benign, uncertain-significance, not specified, Tuberous sclerosis 2 | 2,048,698(-) | C/A | upstream_transcript_variant | |
rs1060504100 | likely-benign, Tuberous sclerosis 2, Hereditary cancer-predisposing syndrome | 2,048,738(-) | C/T | upstream_transcript_variant | |
rs1060504108 | likely-benign, Tuberous sclerosis 2 | 2,048,675(-) | A/C/G | upstream_transcript_variant | |
rs1060504110 | likely-benign, Tuberous sclerosis 2 | 2,048,729(-) | T/C | upstream_transcript_variant | |
rs137854019 | not-provided, Tuberous sclerosis syndrome | 2,048,634(-) | AAA/AA | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4859n54 | CNV | loss | 21841781 |
esv2422427 | CNV | duplication | 17116639 |
nsv1160329 | CNV | deletion | 26073780 |
nsv471072 | CNV | loss | 18288195 |
nsv523037 | CNV | loss | 19592680 |
nsv952901 | CNV | deletion | 24416366 |
Additional Variant Information for NTHL1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTHL1 Gene
Disorders for NTHL1 Gene

(2) MalaCards diseases for NTHL1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
familial adenomatous polyposis 3 |
|
|
periampullary adenoma |
|
|
UniProtKB/Swiss-Prot
NTH_HUMAN- Familial adenomatous polyposis 3 (FAP3) [MIM:616415]: A form of familial adenomatous polyposis, a condition characterized by the development of multiple colorectal adenomatous polyps, benign neoplasms derived from glandular epithelium. Some affected individuals may develop colorectal carcinoma. {ECO:0000269 PubMed:25938944}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for NTHL1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for NTHL1 Gene
Publications for NTHL1 Gene
- Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III. (PMID: 8990169) Aspinwall R … Hickson ID (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 58
- Altered expression of the human base excision repair gene NTH1 in gastric cancer. (PMID: 19414504) Goto M … Sugimura H (Carcinogenesis 2009) 3 22 44 58
- Inherited predisposition to colorectal adenomas caused by multiple rare alleles of MUTYH but not OGG1, NUDT1, NTH1 or NEIL 1, 2 or 3. (PMID: 18515411) Dallosso AR … Sampson JR (Gut 2008) 3 22 44 58
- Substrate specificity of human endonuclease III (hNTH1). Effect of human APE1 on hNTH1 activity. (PMID: 12519758) Marenstein DR … Teebor GW (The Journal of biological chemistry 2003) 3 4 22 58
- Genomic structure and sequence of a human homologue (NTHL1/NTH1) of Escherichia coli endonuclease III with those of the adjacent parts of TSC2 and SLC9A3R2 genes. (PMID: 9831664) Imai K … Seki S (Gene 1998) 3 4 22 58
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- GeneTex NTHL1 antibody for NTHL1
- Search GeneTex for Proteins for NTHL1
- ViGene Biosciences adenoviral particle packaged cDNA for NTHL1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for NTHL1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for NTHL1 gene
- Search ViGene Biosciences for NTHL1
- Santa Cruz Biotechnology (SCBT) Antibodies for NTHL1
- Search Santa Cruz Biotechnology (SCBT) for NTHL1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for NTHL1
- Horizon Cell Lines for NTHL1
Sources for NTHL1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew