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Aliases for NTF4 Gene

Aliases for NTF4 Gene

  • Neurotrophin 4 2 3 5
  • Neurotrophin 5 (Neurotrophin 4/5) 2 3
  • Neurotrophic Factor 4 2 3
  • Neutrophic Factor 4 3 4
  • Neurotrophin-5 3 4
  • NTF5 3 4
  • NT-4 3 4
  • NT-5 3 4
  • Neurotrophic Factor 5 3
  • Neurotrophin-4 3
  • NT-4/5 3
  • GLC10 3
  • GLC1O 3
  • NT5 3
  • NT4 3

External Ids for NTF4 Gene

Previous HGNC Symbols for NTF4 Gene

  • NTF5

Previous GeneCards Identifiers for NTF4 Gene

  • GC19M054257
  • GC19M049564
  • GC19M045941
  • GC19M049565
  • GC19M049055

Summaries for NTF4 Gene

Entrez Gene Summary for NTF4 Gene

  • This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTF4 Gene

NTF4 (Neurotrophin 4) is a Protein Coding gene. Diseases associated with NTF4 include Glaucoma 1, Open Angle, 1O and Hypochondriasis. Among its related pathways are p70S6K Signaling and Akt Signaling. GO annotations related to this gene include receptor binding and neurotrophin p75 receptor binding. An important paralog of this gene is BDNF.

UniProtKB/Swiss-Prot for NTF4 Gene

  • Target-derived survival factor for peripheral sensory sympathetic neurons.

Gene Wiki entry for NTF4 Gene

Additional gene information for NTF4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTF4 Gene

Genomics for NTF4 Gene

Regulatory Elements for NTF4 Gene

Enhancers for NTF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H049072 1.2 FANTOM5 ENCODE 18.2 -8.6 -8604 1.7 HDAC1 HDGF RAD21 ZNF366 ZNF654 ZBTB2 YY2 ZBTB11 NCOA1 ELF1 NTF4 SNRNP70 CGB8 KCNA7 MAMSTR SULT2B1 GC19P049082
GH19H048977 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +85.9 85930 2.9 PKNOX1 ATF1 SIN3A GLIS2 ZNF143 FOS ATF7 RUNX3 SP3 JUNB NUCB1-AS1 NUCB1 KCNA7 TULP2 CGB7 NTF4 C19orf73 FUT1 GYS1 RUVBL2
GH19H048988 1.5 FANTOM5 ENCODE 11.6 +73.0 73023 7.2 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 ZBTB7B YY1 NUP62 GRWD1 ENSG00000268047 TSKS RUVBL2 AKT1S1 LOC101059948 TRPM4 NUCB1 CYTH2
GH19H049145 1.5 Ensembl ENCODE dbSUPER 11.5 -81.3 -81306 1.6 ATF1 ARNT ARID4B SIN3A ZNF121 GLIS2 ZNF143 ATF7 SP3 REST SNRNP70 PPFIA3 PRR12 C19orf73 LIN7B KCNA7 NTF4 CGB7 CD37 SLC6A16
GH19H049207 1.5 FANTOM5 Ensembl ENCODE 11.3 -143.3 -143256 1.4 HDAC1 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 RAD21 RFX5 ZNF366 SNRNP70 PPP1R15A PRR12 CD37 PPFIA3 C19orf73 LIN7B CGB7 NTF4 SLC6A16
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NTF4 on UCSC Golden Path with GeneCards custom track

Promoters for NTF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110830 76 401 CTCF MAZ SP2

Genomic Locations for NTF4 Gene

Genomic Locations for NTF4 Gene
4,011 bases
Minus strand

Genomic View for NTF4 Gene

Genes around NTF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NTF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NTF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTF4 Gene

Proteins for NTF4 Gene

  • Protein details for NTF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6FH56

    Protein attributes for NTF4 Gene

    210 amino acids
    Molecular mass:
    22427 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NTF4 Gene

neXtProt entry for NTF4 Gene

Post-translational modifications for NTF4 Gene

  • Glycosylation at Asn76
  • Modification sites at PhosphoSitePlus

Other Protein References for NTF4 Gene

No data available for DME Specific Peptides for NTF4 Gene

Domains & Families for NTF4 Gene

Gene Families for NTF4 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for NTF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NGF-beta family.
  • Belongs to the NGF-beta family.
genes like me logo Genes that share domains with NTF4: view

Function for NTF4 Gene

Molecular function for NTF4 Gene

UniProtKB/Swiss-Prot Function:
Target-derived survival factor for peripheral sensory sympathetic neurons.

LifeMap Function Summary for NTF4 Gene

NTF4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Phenotypes From GWAS Catalog for NTF4 Gene

Gene Ontology (GO) - Molecular Function for NTF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005166 neurotrophin p75 receptor binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0008083 growth factor activity IBA,IEA --
genes like me logo Genes that share ontologies with NTF4: view
genes like me logo Genes that share phenotypes with NTF4: view

Human Phenotype Ontology for NTF4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for NTF4 Gene

MGI Knock Outs for NTF4:

miRNA for NTF4 Gene

miRTarBase miRNAs that target NTF4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for NTF4 Gene

Localization for NTF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTF4 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NTF4 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NTF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS,IEA 10908605
GO:0005788 endoplasmic reticulum lumen ISS 925010
GO:0031410 cytoplasmic vesicle IBA --
genes like me logo Genes that share ontologies with NTF4: view

Pathways & Interactions for NTF4 Gene

genes like me logo Genes that share pathways with NTF4: view

Interacting Proteins for NTF4 Gene

SIGNOR curated interactions for NTF4 Gene


Gene Ontology (GO) - Biological Process for NTF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007267 cell-cell signaling IBA --
GO:0007402 ganglion mother cell fate determination ISS 10681461
GO:0007616 long-term memory ISS 10869436
GO:0008052 sensory organ boundary specification ISS 10479455
genes like me logo Genes that share ontologies with NTF4: view

Drugs & Compounds for NTF4 Gene

(15) Drugs for NTF4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(5) Additional Compounds for NTF4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NTF4: view

Transcripts for NTF4 Gene

mRNA/cDNA for NTF4 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NTF4 Gene

Neurotrophin 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NTF4 Gene

No ASD Table

Relevant External Links for NTF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NTF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NTF4 Gene

mRNA differential expression in normal tissues according to GTEx for NTF4 Gene

This gene is overexpressed in Prostate (x7.3), Skin - Not Sun Exposed (Suprapubic) (x7.1), Skin - Sun Exposed (Lower leg) (x5.7), Esophagus - Mucosa (x5.0), Muscle - Skeletal (x4.4), Vagina (x4.2), and Bladder (x4.1).

Protein differential expression in normal tissues from HIPED for NTF4 Gene

This gene is overexpressed in Breast (46.1) and Pancreatic juice (21.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NTF4 Gene

Protein tissue co-expression partners for NTF4 Gene

NURSA nuclear receptor signaling pathways regulating expression of NTF4 Gene:


SOURCE GeneReport for Unigene cluster for NTF4 Gene:


mRNA Expression by UniProt/SwissProt for NTF4 Gene:

Tissue specificity: Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.

Evidence on tissue expression from TISSUES for NTF4 Gene

  • Nervous system(3.8)
  • Muscle(2.1)
  • Adrenal gland(2)
  • Eye(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for NTF4 Gene

Germ Layers:
  • ectoderm
  • nervous
Head and neck:
  • eye
  • head
genes like me logo Genes that share expression patterns with NTF4: view

Orthologs for NTF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NTF4 33 34
  • 100 (n)
(Canis familiaris)
Mammalia NTF4 33 34
  • 88.73 (n)
(Bos Taurus)
Mammalia NTF4 33 34
  • 88.41 (n)
(Rattus norvegicus)
Mammalia Ntf4 33
  • 84.05 (n)
(Mus musculus)
Mammalia Ntf5 33 16 34
  • 83.73 (n)
(Monodelphis domestica)
Mammalia NTF4 34
  • 76 (a)
(Anolis carolinensis)
Reptilia NTF4 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ntf4 33
  • 56.13 (n)
(Danio rerio)
Actinopterygii NTF4 34
  • 50 (a)
Species where no ortholog for NTF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTF4 Gene

Gene Tree for NTF4 (if available)
Gene Tree for NTF4 (if available)

Paralogs for NTF4 Gene

Paralogs for NTF4 Gene

(3) SIMAP similar genes for NTF4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NTF4: view

Variants for NTF4 Gene

Sequence variations from dbSNP and Humsavar for NTF4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs121918427 Pathogenic, Glaucoma 1, open angle, O (GLC1O) [MIM:613100] 49,061,382(-) TCAGC(C/T)GGACT nc-transcript-variant, reference, missense
rs121918428 Pathogenic, Glaucoma 1, open angle, O (GLC1O) [MIM:613100] 49,061,381(-) CAGCC(A/G)GACTG nc-transcript-variant, reference, missense
rs200675509 Glaucoma 1, open angle, O (GLC1O) [MIM:613100] 49,061,373(+) GGCCC(A/C/G)GCCAG nc-transcript-variant, reference, missense
rs756962734 Glaucoma 1, open angle, O (GLC1O) [MIM:613100] 49,061,748(+) AGTTT(C/T)GCTCA nc-transcript-variant, reference, missense
rs766504681 Glaucoma 1, open angle, O (GLC1O) [MIM:613100] 49,061,729(+) CCCGA(C/T)GACTC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NTF4 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV gain+loss 18304495
nsv953598 CNV deletion 24416366
nsv833859 CNV loss 17160897
nsv833857 CNV loss 17160897
nsv520785 CNV gain 19592680
esv3644612 CNV gain 21293372

Variation tolerance for NTF4 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.00; 74.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NTF4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NTF4 Gene

Disorders for NTF4 Gene

MalaCards: The human disease database

(8) MalaCards diseases for NTF4 Gene - From: HGMD, OMIM, ClinVar, GeneTests, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
glaucoma 1, open angle, 1o
  • glaucoma 1, open angle, o
  • hypochondria
open-angle glaucoma
  • glaucoma simplex
hypertrophic pyloric stenosis
  • congenital hypertrophic pyloric stenosis
pyloric stenosis
- elite association - COSMIC cancer census association via MalaCards
Search NTF4 in MalaCards View complete list of genes associated with diseases


  • Glaucoma 1, open angle, O (GLC1O) [MIM:613100]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. {ECO:0000269 PubMed:19765683, ECO:0000269 PubMed:20215012}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

Relevant External Links for NTF4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NTF4: view

No data available for Genatlas for NTF4 Gene

Publications for NTF4 Gene

  1. Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. (PMID: 19765683) Pasutto F … Reis A (American journal of human genetics 2009) 3 4 22 60
  2. The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk-binding site. (PMID: 10631974) Robinson RC … Jones EY (Protein science : a publication of the Protein Society 1999) 3 4 22 60
  3. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. (PMID: 1313578) Ip NY … Squinto SP (Proceedings of the National Academy of Sciences of the United States of America 1992) 3 4 22 60
  4. Human chromosome 19 contains the neurotrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins. (PMID: 1496419) Berkemeier LR … Rosenthal A (Somatic cell and molecular genetics 1992) 2 3 22 60
  5. Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development. (PMID: 20175187) Childs AJ … Anderson RA (Developmental dynamics : an official publication of the American Association of Anatomists 2010) 3 22 60

Products for NTF4 Gene

Sources for NTF4 Gene

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