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Aliases for NTF4 Gene

Aliases for NTF4 Gene

  • Neurotrophin 4 2 3
  • NTF5 3 4 6
  • Neurotrophin 5 (Neurotrophin 4/5) 2 3
  • Neurotrophic Factor 4 2 3
  • Neutrophic Factor 4 3 4
  • Neurotrophin-5 3 4
  • GLC1O 3 6
  • NT-4 3 4
  • NT-5 3 4
  • NT5 3 6
  • NT4 3 6
  • Neurotrophic Factor 5 3
  • Neurotrophin-4 3
  • NT-4/5 3
  • GLC10 3
  • NTF4 6

External Ids for NTF4 Gene

Previous Symbols for NTF4 Gene

  • NTF5

Summaries for NTF4 Gene

Entrez Gene Summary for NTF4 Gene

  • This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTF4 Gene

NTF4 (Neurotrophin 4) is a Protein Coding gene. Diseases associated with NTF4 include head injury and glaucoma 1, open angle, 1o. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include growth factor activity. An important paralog of this gene is BDNF.

UniProtKB/Swiss-Prot for NTF4 Gene

  • Target-derived survival factor for peripheral sensory sympathetic neurons

Gene Wiki entry for NTF4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTF4 Gene

Genomics for NTF4 Gene

Genomic Location for NTF4 Gene

Start:
49,055,793 bp from pter
End:
49,065,076 bp from pter
Size:
9,284 bases
Orientation:
Minus strand

Genomic View for NTF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTF4 Gene

Regulatory Elements for NTF4 Gene

Proteins for NTF4 Gene

  • Protein details for NTF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P34130-NTF4_HUMAN
    Recommended name:
    Neurotrophin-4
    Protein Accession:
    P34130
    Secondary Accessions:
    • Q6FH56

    Protein attributes for NTF4 Gene

    Size:
    210 amino acids
    Molecular mass:
    22427 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NTF4 Gene

neXtProt entry for NTF4 Gene

Proteomics data for NTF4 Gene at MOPED

Post-translational modifications for NTF4 Gene

Other Protein References for NTF4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NTF4 Gene

Domains for NTF4 Gene

Gene Families for NTF4 Gene

HGNC:

UniProtKB/Swiss-Prot:

NTF4_HUMAN
Family:
  • Belongs to the NGF-beta family.:
    • P34130
genes like me logo Genes that share domains with NTF4: view

Function for NTF4 Gene

Molecular function for NTF4 Gene

UniProtKB/Swiss-Prot Function: Target-derived survival factor for peripheral sensory sympathetic neurons

LifeMap Function Summary for NTF4 Gene

NTF4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for NTF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005166 neurotrophin p75 receptor binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with NTF4: view
genes like me logo Genes that share phenotypes with NTF4: view

Animal Models for NTF4 Gene

MGI Knock Outs for NTF4:

miRNA for NTF4 Gene

miRTarBase miRNAs that target NTF4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NTF4 Gene

Localization for NTF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTF4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTF4 Gene COMPARTMENTS Subcellular localization image for NTF4 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytoskeleton 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for NTF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS 10908605
GO:0005788 endoplasmic reticulum lumen ISS 925010
GO:0016023 cytoplasmic membrane-bounded vesicle IBA --
genes like me logo Genes that share ontologies with NTF4: view

Pathways for NTF4 Gene

genes like me logo Genes that share pathways with NTF4: view

Interacting Proteins for NTF4 Gene

Gene Ontology (GO) - Biological Process for NTF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0007267 cell-cell signaling IBA --
GO:0007402 ganglion mother cell fate determination ISS 10681461
GO:0007616 long-term memory ISS 10869436
GO:0008052 sensory organ boundary specification ISS 10479455
genes like me logo Genes that share ontologies with NTF4: view

Compounds for NTF4 Gene

(20) Novoseek inferred chemical compound relationships for NTF4 Gene

Compound -log(P) Hits PubMed IDs
k252a 78.9 2
tyrosine 61.3 30
choline 22.3 3
quinolinic acid 21.5 1
glutamate 16.8 2
genes like me logo Genes that share compounds with NTF4: view

Transcripts for NTF4 Gene

mRNA/cDNA for NTF4 Gene

(6) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NTF4 Gene

Neurotrophin 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTF4 Gene

No ASD Table

Relevant External Links for NTF4 Gene

GeneLoc Exon Structure for
NTF4
ECgene alternative splicing isoforms for
NTF4

Expression for NTF4 Gene

mRNA expression in normal human tissues for NTF4 Gene

mRNA differential expression in normal tissues according to GTEx for NTF4 Gene

This gene is overexpressed in Prostate (7.3), Skin - Not Sun Exposed (Suprapubic) (7.1), Skin - Sun Exposed (Lower leg) (5.7), Esophagus - Mucosa (5.0), Muscle - Skeletal (4.4), Vagina (4.2), and Bladder (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for NTF4 Gene

SOURCE GeneReport for Unigene cluster for NTF4 Gene Hs.266902

mRNA Expression by UniProt/SwissProt for NTF4 Gene

P34130-NTF4_HUMAN
Tissue specificity: Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues
genes like me logo Genes that share expressions with NTF4: view

Orthologs for NTF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTF4 36
  • 100 (n)
  • 100 (a)
NTF4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NTF4 36
  • 88.41 (n)
  • 90.48 (a)
NTF4 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTF4 36
  • 88.73 (n)
  • 93.33 (a)
NTF4 37
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntf5 36
  • 83.73 (n)
  • 89.47 (a)
Ntf5 16
Ntf5 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTF4 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntf4 36
  • 84.05 (n)
  • 89.47 (a)
lizard
(Anolis carolinensis)
Reptilia NTF4 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntf4 36
  • 56.13 (n)
  • 57.47 (a)
zebrafish
(Danio rerio)
Actinopterygii NTF4 37
  • 50 (a)
OneToOne
Species with no ortholog for NTF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTF4 Gene

ENSEMBL:
Gene Tree for NTF4 (if available)
TreeFam:
Gene Tree for NTF4 (if available)

Paralogs for NTF4 Gene

Paralogs for NTF4 Gene

Selected SIMAP similar genes for NTF4 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for NTF4 Gene

genes like me logo Genes that share paralogs with NTF4: view

Variants for NTF4 Gene

Sequence variations from dbSNP and Humsavar for NTF4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3810184 -- 49,064,035(+) GATGG(A/G)AAGCA upstream-variant-2KB, intron-variant
rs10419206 -- 49,062,724(+) ggttg(A/T)ggtgg intron-variant
rs10421637 -- 49,066,804(+) ttcta(A/G)gtccc upstream-variant-2KB
rs11669977 -- 49,060,867(+) TTCCC(A/G)TTTGA downstream-variant-500B
rs11672068 -- 49,066,241(+) TTTAT(G/T)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NTF4 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
nsv912248 CNV Loss 21882294
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912251 CNV Loss 21882294
nsv912252 CNV Loss 21882294
nsv520785 CNV Gain 19592680
nsv912254 CNV Loss 21882294
nsv912255 CNV Loss 21882294
nsv912256 CNV Loss 21882294

Relevant External Links for NTF4 Gene

HapMap Linkage Disequilibrium report
NTF4
Human Gene Mutation Database (HGMD)
NTF4

Disorders for NTF4 Gene

(1) OMIM Diseases for NTF4 Gene (162662)

UniProtKB/Swiss-Prot

NTF4_HUMAN
  • Glaucoma 1, open angle, O (GLC1O) [MIM:613100]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for NTF4 Gene

(16) Novoseek inferred disease relationships for NTF4 Gene

Disease -log(P) Hits PubMed IDs
neurodegenerative diseases 43.3 1
neurological disorders 30.1 1
neurodegeneration 20 1
alzheimers disease 7.41 2
epithelial tumor 5.95 1

Relevant External Links for NTF4

Genetic Association Database (GAD)
NTF4
Human Genome Epidemiology (HuGE) Navigator
NTF4
genes like me logo Genes that share disorders with NTF4: view

Publications for NTF4 Gene

  1. Human chromosome 19 contains the neurotrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins. (PMID: 1496419) Berkemeier L.R. … Rosenthal A. (Somat. Cell Mol. Genet. 1992) 2 3 23
  2. The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk- binding site. (PMID: 10631974) Robinson R.C. … Jones E.Y. (Protein Sci. 1999) 3 4 23
  3. Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. (PMID: 19765683) Pasutto F. … Reis A. (Am. J. Hum. Genet. 2009) 3 4 23
  4. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. (PMID: 1313578) Ip N.Y. … Yancopoulos G.D. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  5. Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development. (PMID: 20175187) Childs A.J. … Anderson R.A. (Dev. Dyn. 2010) 3 23

Products for NTF4 Gene

Sources for NTF4 Gene

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