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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NTF4 Gene

protein-coding   GIFtS: 62
GCID: GC19M049564

neurotrophin 4

(Previous name: neurotrophin 5 (neurotrophin 4/5) )
(Previous symbol: NTF5)
 Explore 46 diseases affiliated with
NTF4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NTF4    

Aliases
for NTF4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Neurotrophin 41 2     NT42 5
NTF51 2 3 5     NT52 5
GLC1O1 2 5     GLC102
NT-4/51 2     Neurotrophic Factor 42
Neurotrophin 5 (Neurotrophin 4/5)1 2     Neurotrophic Factor 52
Neutrophic Factor 42 3     Neurotrophin-41
NT-42 3     Neurotrophin-53
NT-52 3     Neurotrophin-53

External Ids:    HGNC: 80241   Entrez Gene: 49092   Ensembl: ENSG000001677447   OMIM: 1626625   UniProtKB: P341303   

Export aliases for NTF4 gene to outside databases

Previous GC identifers: GC19M054257 GC19M045941


Summaries
for NTF4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NTF4:
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of
mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While
knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3
prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop
normally to adulthood. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NTF4_HUMAN, P34130
Function: Target-derived survival factor for peripheral sensory sympathetic neurons

Gene Wiki entry for NTF4 (Neurotrophin-4)


Genomic Views
for NTF4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NTF4 gene promoter:
         p53   Brachyury   NF-YA   Egr-4   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NTF4 promoter sequence
   Search SABiosciences Chromatin IP Primers for NTF4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

NTF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTF4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049564:  view genomic region     (about GC identifiers)

Start:
 49,564,397 bp from pter      End:
 49,568,235 bp from pter
Size:
 3,839 bases      Orientation:
 minus strand

Proteins
for NTF4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NTF4_HUMAN, P34130 (See protein sequence)
Recommended Name: Neurotrophin-4 precursor  
Size: 210 amino acids; 22427 Da
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for NTF4:
1B8M (3D)        1B98 (3D)        1HCF (3D)    
Secondary accessions: Q6FH56

Explore the universe of human proteins at neXtProt for NTF4: NX_P34130

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P34130

    • NTF4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006170.1  
    ENSEMBL proteins: 
     ENSP00000301411  

    Human Recombinant Protein Products: 
    EMD Millipore Purified and/or Recombinant NTF4 Protein
    R&D Systems Recombinant & Natural Proteins for NTF4 (NT-4)
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    OriGene Protein Over-expression Lysate: NTF4
    OriGene Custom Protein Services for NTF4 
    GenScript Purified and Recombinant Proteins for NTF4
    Novus Biologicals NTF4 Proteins
    Novus Biologicals NTF4 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for NTF4
    Uscn Proteins for NTF4

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ISS10908605
    GO:0005788endoplasmic reticulum lumen ISS925010


    NTF4 for ontologies           About GeneDecksing



    NTF4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of NTF4
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    OriGene Antibodies (see all 3): NTF4
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    Abcam antibodies for NTF4 
    Uscn Antibodies for NTF4
    ThermoFisher Antibodies for NTF4

    Assay Products for NTF4: 
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    Uscn ELISAs and CLIAs for NTF4

    Protein Domains /
    Families
    for NTF4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NTF4 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020432 Neurotrophin-4
     IPR002072 Nerve_growth_factor-rel
     IPR019846 Nerve_growth_factor_CS
     IPR020408 Nerve_growth_factor-like

    Graphical View of Domain Structure for InterPro Entry P34130

    ProtoNet protein and cluster: P34130

    1 Blocks protein family: IPB002072 Nerve growth factor

    UniProtKB/Swiss-Prot: NTF4_HUMAN, P34130
    Similarity: Belongs to the NGF-beta family


    Function
    for NTF4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NTF4_HUMAN, P34130
    Function: Target-derived survival factor for peripheral sensory sympathetic neurons

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTF4
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NTF4:
    hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: NTF4 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTF4 (see all 4)
    OriGene shRNA RFP: NTF4
    OriGene siRNA: NTF4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTF4

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NTF4

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTF4 (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: NTF4 (NM_006179)
    Sino Biological Human cDNA Clone for NTF4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTF4 

    Cell Line
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    Search LifeMap BioReagents cell lines for NTF4

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NTF4

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008083growth factor activity IEA--


    NTF4 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NTF4:
     Decreased homologous recombina 

    Animal Models:
         Mouse knock-outs for NTF4: Ntf5tm1Gdy Ntf5tm1Jae Ntf5tm1Par
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ntf5):
     behavior/neurological  cellular  growth/size  integument  mortality/aging 
     nervous system 

    NTF4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NTF4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development HGF signaling pathway
    		Development_Neurotrophin family signaling0.45
    		Neurotrophin signaling pathway0.20
    		Development Neurotrophin family signaling0.45
    2Development MAG-dependent inhibition of neurite outgrowth
    		Development MAG-dependent inhibition of neurite outgrowth1.00
    		Development_MAG-dependent inhibition of neurite outgrowth0.87
    3MAPK signaling pathway
    		MAPK signaling pathway1.00
    		MAPK signaling pathway0.50
    4p75(NTR)-mediated signaling
    		p75(NTR)-mediated signaling1.00
    5Neurotrophic factor-mediated Trk receptor signaling
    		Neurotrophic factor-mediated Trk receptor signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for NTF4
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    1 R&D Systems Pathway for NTF4
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions


    2 GeneGo (Thomson Reuters) Pathways for NTF4
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    3 BioSystems Pathways for NTF4 
        MAPK signaling pathway
    p75(NTR)-mediated signaling
    Neurotrophic factor-mediated Trk receptor signaling


    2         Kegg Pathways  (Kegg details for NTF4):
        MAPK signaling pathway
    Neurotrophin signaling pathway


    NTF4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NTF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/9 Interacting proteins for NTF4 (P341302, 3 ENSP000003014114) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NGFRP081383, ENSP000001722294I2D: score=2 STRING: ENSP00000172229
    BDNFP235603, ENSP000004143034I2D: score=1 STRING: ENSP00000414303
    NTRK2Q166203, ENSP000002771204I2D: score=3 STRING: ENSP00000277120
    NTRK3ENSP000003542074STRING: ENSP00000354207
    NGFENSP000003585254STRING: ENSP00000358525
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007402ganglion mother cell fate determination ISS10681461
    GO:0007616long-term memory ISS10869436
    GO:0008052sensory organ boundary specification ISS10479455
    GO:0008344adult locomotory behavior ISS10681461
    GO:0008544epidermis development ISS9973328


    NTF4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for NTF4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NTF4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NTF4
    10/20 Novoseek chemical compound relationships for NTF4 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    k252a 78.9 2 9133581 (1), 10684891 (1)
    tyrosine 61.3 44 10486198 (4), 18190610 (1), 19490633 (1), 19765683 (1) (see all 27)
    choline 22.3 3 8580713 (1), 9121684 (1), 10527802 (1)
    quinolinic acid 21.5 2 9588602 (1)
    glutamate 16.8 2 10391433 (1), 10553907 (1)
    forskolin 8.36 1 12832528 (1)
    phosphatidylinositol 2.42 1 11948662 (1)
    ethanol 0 3 8666023 (1), 12586429 (1)
    calcium 0 5 10938435 (3), 15703301 (1)
    alanine 0 1 11461677 (1)

    Search CenterWatch for drugs/clinical trials and news about NTF4 

    Transcripts
    for NTF4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NTF4 gene: 
    NM_006179.4  

    Unigene Clusters for NTF4:

    Neurotrophin 4
    Hs.266902  [show with all ESTs], Hs.743915  [show with all ESTs]
    Unigene Representative Sequences: BC012421, AK297906
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000301411(uc002pmf.4)

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTF4
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NTF4:
    hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmid: NTF4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTF4 (see all 4)
    OriGene shRNA RFP: NTF4
    OriGene siRNA: NTF4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTF4
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTF4 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTF4
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    GenScript: all cDNA clones in your preferred vector: NTF4 (NM_006179)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTF4 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTF4
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NTF4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTF4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTF4

    Additional cDNA sequence: AK297906.1 

    3 DOTS entries:

    DT.40127754  DT.97813911  DT.97797965 

    11 AceView cDNA sequences:

    CR541900 T28141 BC012421 NM_006179 BM983251 BF037669 BF931090 AW372597 
    AA427578 BE535636 BF982432 

    GeneLoc Exon Structure


    Expression
    for NTF4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NTF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NTF4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    OvaryOvigerous CordOvarian Somatic CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See NTF4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NTF4

    SOURCE GeneReport for Unigene clusters: Hs.266902 Hs.743915

    UniProtKB/Swiss-Prot: NTF4_HUMAN, P34130
    Tissue specificity: Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in
    embryonic and adult tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including NTF4: 
              Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTF4
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTF4
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for NTF4

    Orthologs
    for NTF4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for NTF4 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ntf51 , 5 neurotrophin 51, 5 84.37(n)1
    91.39(a)1    		   7 (29.30 cM)5
    784051  NM_198190.11  NP_937833.11 
     454136955 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1003312871 uncharacterized LOC100331287 53.83(n)
    51.55(a)    		   100331287  XM_002661176.1  XP_002661222.1 


    ENSEMBL Gene Tree for NTF4 (if available)
    TreeFam Gene Tree for NTF4 (if available) 

    Paralogs
    for NTF4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NTF4 gene
    NTF32  BDNF2  NGF2  
    3 SIMAP similar genes for NTF4 using alignment to 4 protein entries:     NTF4_HUMAN (see all proteins):
    NTF3    NGF    BDNF

    NTF4 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for NTF4
    PGOHUM00000259346 PGOHUM00000259347 PGOHUM00000259348 PGOHUM00000259412 PGOHUM00000259413


    Genomic Variants
    for NTF4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/62 NCBI SNPs in NTF4 are shown (see all 62)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs617323101,2
    		C,F,pathogenic48021076(-) ACCAGC/TGAGTC 2 A V mis12Minor allele frequency- T:0.00NS NA 3418
    rs1219184271,2
    		Cpathogenic48021429(-) TCAGCC/TGGACT 2 R W mis11Minor allele frequency- T:0.00EU 929
    rs798359311,2
    		--45940774(+) GCCCCC/TTCTTA 1 -- ds50012Minor allele frequency- T:0.02CSA WA 120
    rs1159696171,2
    		C,F,--45941184(+) GAGAAT/CTGTGA 1 -- ut311Minor allele frequency- C:0.05WA 118
    rs771132001,2
    		C,F,--45942090(+) CTTGCG/ATAATG 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1175099171,2
    		C,F,--45942097(+) AATGCG/ACAACT 1 -- int11Minor allele frequency- A:0.03EA 120
    rs346195241,2
    		--45944049(-) TGGGCC/TGAGGG 1 -- us2k10--------
    rs730467651,2
    		C,--45944264(+) AAGGAG/ACCCAG 1 -- us2k12Minor allele frequency- A:0.02NA 122
    rs750521561,2
    		C--45944533(-) TGAGGG/AAGGAG 1 -- us2k11Minor allele frequency- A:0.00NA 2
    rs798193991,2
    		C--45944541(-) CCTGGT/GTCTGA 1 -- us2k12Minor allele frequency- G:0.00NA 4

    HapMap Linkage Disequilibrium report for NTF4 (49564397 - 49568235 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for NTF4
         3 CNVs: 50192 5109 32261
    Human Gene Mutation Database (HGMD): NTF4

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for NTF4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NTF4 for disorders           About GeneDecksing

    OMIM gene information: 162662   
    OMIM disorders: 613100  
    UniProtKB/Swiss-Prot: NTF4_HUMAN, P34130
  • Defects in NTF4 may be associated with susceptibility to primary open angle glaucoma type 1O (GLC1O)
    • [MIM:613100]. A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve
    and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure
    is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic
    nerve damage has already taken place

    20/46 diseases for NTF4 (see all 46):    About MalaCards
    angle-closure glaucoma    glaucoma 1, open angle, 1o    open-angle glaucoma    primary angle-closure glaucoma
    relapsing-remitting multiple sclerosis    primary open angle glaucoma    glaucoma    proliferative vitreoretinopathy
    amyotrophic lateral sclerosis    lateral sclerosis    eating disorder    vitreoretinopathy
    bronchial asthma    head injury    atopic dermatitis    peripheral neuropathy
    tuberous sclerosis    multiple sclerosis    neurodegenerative disease    heterotopia

    1 disease from the University of Copenhagen DISEASES database for NTF4:
    Neurodegenerative disease

    10/16 Novoseek disease relationships for NTF4 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 43.3 1 11855816 (1)
    neurological disorders 30.1 1 7838303 (1)
    neurodegeneration 20 1 10867782 (1)
    alzheimers disease 7.41 2 10867782 (1), 9121684 (1)
    epithelial tumor 5.95 1 10440874 (1)
    tumors 3.22 4 15605111 (1), 8905447 (1), 19403498 (1)
    autistic 1.66 1 11357950 (1)
    dermatitis atopic 1.55 4 10844552 (2), 16081678 (2)
    parkinson disease 0.945 2 11429269 (1)
    skin lesion 0 2 10844552 (1), 16081678 (1)

    Human Genome Epidemiology (HuGE) Navigator: NTF4 (8 documents)

    Export disorders for NTF4 gene to outside databases

    Publications
    for NTF4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NTF4 gene, integrated from 9 sources (see all 272):
    (articles sorted by number of sources associating them with NTF4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. (PubMed id 19765683)1, 2, 9 Pasutto F....Reis A. (2009)
    2. The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk- binding site. (PubMed id 10631974)1, 2, 9 Robinson R.C.... Jones E.Y. (1999)
    3. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. (PubMed id 1313578)1, 2, 9 Ip N.Y....Yancopoulos G.D. (1992)
    4. Human chromosome 19 contains the neurotrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins. (PubMed id 1496419)1, 3, 9 Berkemeier L.R.... Rosenthal A. (1992)
    5. No evidence of association of heterozygous NTF4 mutat ions in patients with primary open-angle glaucoma. (PubMed id 20215012)1, 2 Liu Y....Hauser M.A. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. (PubMed id 1742028)1, 2 Berkemeier L.R....Rosenthal A. (1991)
    8. Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development. (PubMed id 20175187)1, 9 Childs A.J....Anderson R.A. (2010)
    9. Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle. (PubMed id 16648236)1, 9 Prakash Y.S....Pabelick C.M. (2006)
    10. A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4. (PubMed id 11855816)1, 9 Naylor R.L....Dawbarn D. (2002)

    External Searches for NTF4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing NTF4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4909 HGNC: 8024 AceView: NTF5 Ensembl:ENSG00000167744 euGenes: HUgn4909
    ECgene: NTF4 Kegg: 4909 H-InvDB: NTF4

    Other Databases showing NTF4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NTF4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NTF4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NTF4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NTF4 gene:
    Search GeneIP for patents involving NTF4

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