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NTF4 Gene

protein-coding   GIFtS: 62
GCID: GC19M049565

Neurotrophin 4

(Previous name: neurotrophin 5 (neurotrophin 4/5))
(Previous symbol: NTF5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Neurotrophin 41 2     NT42 5
NTF51 2 3 5     NT52 5
Neurotrophin 5 (Neurotrophin 4/5)1 2     GLC102
Neurotrophic Factor 41 2     NT-4/52
Neutrophic Factor 42 3     Neurotrophic Factor 52
NT-42 3     neurotrophin-42
NT-52 3     neurotrophin-52
GLC1O2 5     Neurotrophin-53

External Ids:    HGNC: 80241   Entrez Gene: 49092   Ensembl: ENSG000002259507   OMIM: 1626625   UniProtKB: P341303   

Export aliases for NTF4 gene to outside databases

Previous GC identifers: GC19M054257 GC19M049564 GC19M045941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NTF4 Gene:
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and
differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by
environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived
neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only
show minor cellular deficits and develop normally to adulthood. (provided by RefSeq, Jul 2008)

GeneCards Summary for NTF4 Gene:
NTF4 (neurotrophin 4) is a protein-coding gene. Diseases associated with NTF4 include proliferative vitreoretinopathy, and meningitis and encephalitis. GO annotations related to this gene include growth factor activity. An important paralog of this gene is NTF3.

UniProtKB/Swiss-Prot: NTF4_HUMAN, P34130
Function: Target-derived survival factor for peripheral sensory sympathetic neurons

Gene Wiki entry for NTF4 (Neurotrophin-4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NTF4 gene promoter:
         p53   Brachyury   NF-YA   Egr-4   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNTF4 promoter sequence
   Search Chromatin IP Primers for NTF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

NTF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTF4 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049565:  view genomic region     (about GC identifiers)

Start:
49,559,050 bp from pter      End:
49,568,333 bp from pter
Size:
9,284 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NTF4_HUMAN, P34130 (See protein sequence)
Recommended Name: Neurotrophin-4 precursor  
Size: 210 amino acids; 22427 Da
3 PDB 3D structures from and Proteopedia for NTF4:
1B8M (3D)        1B98 (3D)        1HCF (3D)    
Secondary accessions: Q6FH56

Explore the universe of human proteins at neXtProt for NTF4: NX_P34130

Explore proteomics data for NTF4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn76

  • See NTF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006170.1  
    ENSEMBL proteins: 
     ENSP00000470689   ENSP00000469455   ENSP00000471508   ENSP00000391622   ENSP00000301411  

    NTF4 Human Recombinant Protein Products:

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    Novus Biologicals NTF4 Lysates
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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

    NTF4 Antibody Products:

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    Novus Biologicals NTF4 Antibodies
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR020432 Neurotrophin-4
     IPR002072 Nerve_growth_factor-rel
     IPR019846 Nerve_growth_factor_CS
     IPR020408 Nerve_growth_factor-like

    Graphical View of Domain Structure for InterPro Entry P34130

    ProtoNet protein and cluster: P34130

    1 Blocks protein domain: IPB002072 Nerve growth factor

    UniProtKB/Swiss-Prot: NTF4_HUMAN, P34130
    Similarity: Belongs to the NGF-beta family


    NTF4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTF4_HUMAN, P34130
    Function: Target-derived survival factor for peripheral sensory sympathetic neurons

         Summary: 

    NTF4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Spinal Cord: Expanded oligodendrocyte progenitor cells, Expanded oligodendrocyte progenitor cells
    Brain: Expanded oligodendrocyte progenitor cells, Expanded oligodendrocyte progenitor cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0008083growth factor activity IEA--
         
    NTF4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NTF4:
     Decreased homologous recombina 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Ntf5):
     behavior/neurological  cellular  growth/size/body  integument  mortality/aging 
     nervous system 

    NTF4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NTF4: Ntf5tm1Gdy Ntf5tm1Jae Ntf5tm1Par

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NTF4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NTF4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTF4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTF4

    miRNA
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    miRTarBase miRNAs that target NTF4:
    hsa-mir-124-3p (MIRT022666)

    Block miRNA regulation of human, mouse, rat NTF4 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate NTF4:
    hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidNTF4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NTF4

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: NTF4 (NM_006179)
    Sino Biological Human cDNA Clone for NTF4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTF4

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NTF4_HUMAN, P34130: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum4
    cytoskeleton2
    nucleus2
    plasma membrane2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ISS10908605
    GO:0005788endoplasmic reticulum lumen ISS925010

    NTF4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NTF4 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    3TNF Signaling
    TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions0.49
    4Cell adhesion Integrin mediated cell adhesion and migration
    Development MAG dependent inhibition of neurite outgrowth0.46
    5p75(NTR)-mediated signaling
    p75(NTR)-mediated signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NTF4
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NTF4 (see all 56)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 GeneGo (Thomson Reuters) Pathways for NTF4
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    3 BioSystems Pathways for NTF4
        MAPK signaling pathway
    p75(NTR)-mediated signaling
    Neurotrophic factor-mediated Trk receptor signaling



    2 Kegg Pathways  (Kegg details for NTF4):
        MAPK signaling pathway
    Neurotrophin signaling pathway


    NTF4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NTF4: 
              Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for NTF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for NTF4 (P341302, 3 ENSP000003014114) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NGFRP081383, ENSP000001722294I2D: score=2 STRING: ENSP00000172229
    BDNFP235603, ENSP000004143034I2D: score=1 STRING: ENSP00000414303
    NTRK2Q166203, ENSP000002771204I2D: score=3 STRING: ENSP00000277120
    NTRK3ENSP000003542074STRING: ENSP00000354207
    NGFENSP000003585254STRING: ENSP00000358525
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007402ganglion mother cell fate determination ISS10681461
    GO:0007616long-term memory ISS10869436
    GO:0008052sensory organ boundary specification ISS10479455
    GO:0008344adult locomotory behavior ISS10681461
    GO:0008544epidermis development ISS9973328

    NTF4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NTF4

    Selected Novoseek inferred chemical compound relationships for NTF4 gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    k252a 78.9 2 9133581 (1), 10684891 (1)
    tyrosine 61.3 44 10486198 (4), 18190610 (1), 19490633 (1), 19765683 (1) (see all 27)
    choline 22.3 3 8580713 (1), 9121684 (1), 10527802 (1)
    quinolinic acid 21.5 2 9588602 (1)
    glutamate 16.8 2 10391433 (1), 10553907 (1)
    forskolin 8.36 1 12832528 (1)
    phosphatidylinositol 2.42 1 11948662 (1)
    ethanol 0 3 8666023 (1), 12586429 (1)
    calcium 0 5 10938435 (3), 15703301 (1)
    alanine 0 1 11461677 (1)



    NTF4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NTF4 gene: 
    NM_006179.4  

    Unigene Cluster for NTF4:

    Neurotrophin 4
    Hs.266902  [show with all ESTs]
    Unigene Representative Sequence: BC012421
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000599795 ENST00000593537 ENST00000595857 ENST00000594938 ENST00000451356(uc010yah.1)
    ENST00000301411(uc002pmf.4)
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate NTF4:
    hsa-miR-616* hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidNTF4 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NTF4
      QuantiFast Probe-based Assays in human, mouse, rat NTF4

    Additional mRNA sequence: 

    BC012421.2 BT019368.1 BT019369.1 CR541900.1 

    2 DOTS entries:

    DT.40127754  DT.97813911 

    11 AceView cDNA sequences:

    T28141 CR541900 NM_006179 BC012421 BM983251 BF931090 BF037669 AA427578 
    AW372597 BE535636 BF982432 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NTF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NTF4 Expression
    About this image


    NTF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Bone marrow-derived mesenchymal stem cells
     
     Spinal Cord (Nervous System)
             Motor neuron progenitor cells
     
     Motor Neurons (Nervous System)
             Motor neuron progenitor cells
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord
    NTF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NTF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.266902

    UniProtKB/Swiss-Prot: NTF4_HUMAN, P34130
    Tissue specificity: Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed
    in embryonic and adult tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NTF4: 
              Growth Factors in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NTF4
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    QuantiFast Probe-based Assays in human, mouse, rat NTF4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NTF4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntf51 , 5 neurotrophin 51, 5 83.73(n)1
    89.47(a)1
      7 (29.30 cM)5
    784051  NM_198190.11  NP_937833.11 
     454136955 
    lizard
    (Anolis carolinensis)
    Reptilia NTF46
    neurotrophin 4
    53(a)
    1 ↔ 1
    6(80127662-80128276)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ntf41 neurotrophin 4 56.13(n)
    57.47(a)
      100490781  XM_002939236.2  XP_002939282.1 
    zebrafish
    (Danio rerio)
    Actinopterygii NTF46
    neurotrophin 4
    50(a)
    1 ↔ 1
    3(30189744-30190774) ENSDARG00000078049


    ENSEMBL Gene Tree for NTF4 (if available)
    TreeFam Gene Tree for NTF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NTF4 gene
    NTF32  BDNF2  NGF2  
    3 SIMAP similar genes for NTF4 using alignment to 4 protein entries:     NTF4_HUMAN (see all proteins):
    NTF3    NGF    BDNF

    NTF4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for NTF4
    PGOHUM00000234367


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NTF4 (see all 104)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219184271,2
    Cpathogenic149740945(-) TCAGCC/TGGACT 2 R W mis11Minor allele frequency- T:0.00EU 929
    rs617323101,2
    C,Fpathogenic149741298(-) ACCAGC/TGAGTC 2 A V mis12Minor allele frequency- T:0.00NS NA 3418
    rs345340891,2
    C--45942942(+) TTTTTT/-GAGAC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs749315511,2
    C--49567811(+) GCTCCA/CGCCCC 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs1491877351,2
    --49740241(+) ATGTAC/GAGTAA 1 -- ds50010--------
    rs798359311,2
    C,F--49740408(+) GCCCCC/TTCTTA 1 -- ds50012Minor allele frequency- T:0.02CSA WA 120
    rs116699771,2
    C,F,A,H--49740430(+) TTCCCA/GTTTGA 1 -- ds500133Minor allele frequency- G:0.16NS EA NA WA 3548
    rs1846164681,2
    --49740514(+) TTCTAG/TTTTCT 1 -- ds50010--------
    rs1897916791,2
    --49740692(+) TAAATA/CGTGGC 1 -- ds50010--------
    rs1424196971,2
    --49740695(+) ATAGTA/GGCTAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for NTF4 (49559050 - 49568333 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NTF4 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912256CNV Loss21882294
    nsv912255CNV Loss21882294
    nsv833859CNV Loss17160897
    nsv912248CNV Loss21882294
    nsv833857CNV Loss17160897
    nsv912251CNV Loss21882294
    nsv912254CNV Loss21882294
    dgv3970n71CNV Loss21882294
    nsv912252CNV Loss21882294
    nsv520785CNV Gain19592680

    Human Gene Mutation Database (HGMD): NTF4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NTF4
    DNA2.0 Custom Variant and Variant Library Synthesis for NTF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162662   
    OMIM disorders: 613100  
    UniProtKB/Swiss-Prot: NTF4_HUMAN, P34130
  • Glaucoma 1, open angle, O (GLC1O) [MIM:613100]: A form of primary open angle glaucoma (POAG). POAG is
    characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of
    the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any
    intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and
    irreversible optic nerve damage has already taken place. Note=Disease susceptibility may be associated with
    variations affecting the gene represented in this entry

  • Selected diseases for NTF4 (see all 47):    
    About MalaCards
    proliferative vitreoretinopathy    meningitis and encephalitis    glaucoma 1, open angle, 1o    head injury
    relapsing-remitting multiple sclerosis    primary angle-closure glaucoma    tuberous sclerosis complex    primary open angle glaucoma
    open-angle glaucoma    asperger syndrome    tuberous sclerosis    eating disorder
    glaucoma    meningitis    peripheral neuropathy    encephalitis
    multiple sclerosis    dermatitis    parkinson's disease    atopic dermatitis

    2 diseases from the University of Copenhagen DISEASES database for NTF4:
    Neurodegenerative disease     Glaucoma

    NTF4 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for NTF4 gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neurodegenerative diseases 43.3 1 11855816 (1)
    neurological disorders 30.1 1 7838303 (1)
    neurodegeneration 20 1 10867782 (1)
    alzheimers disease 7.41 2 10867782 (1), 9121684 (1)
    epithelial tumor 5.95 1 10440874 (1)
    tumors 3.22 4 15605111 (1), 8905447 (1), 19403498 (1)
    autistic 1.66 1 11357950 (1)
    dermatitis atopic 1.55 4 10844552 (2), 16081678 (2)
    parkinson disease 0.945 2 11429269 (1)
    skin lesion 0 2 10844552 (1), 16081678 (1)

    Genetic Association Database (GAD): NTF4
    Human Genome Epidemiology (HuGE) Navigator: NTF4 (8 documents)

    Export disorders for NTF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for NTF4 gene, integrated from 10 sources (see all 274):
    (articles sorted by number of sources associating them with NTF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma. (PubMed id 19765683)1, 2, 9 Pasutto F.... Reis A. (Am. J. Hum. Genet. 2009)
    2. The structures of the neurotrophin 4 homodimer and the brain-derived neurotrophic factor/neurotrophin 4 heterodimer reveal a common Trk- binding site. (PubMed id 10631974)1, 2, 9 Robinson R.C.... Jones E.Y. (Protein Sci. 1999)
    3. Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. (PubMed id 1313578)1, 2, 9 Ip N.Y....Yancopoulos G.D. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    4. Human chromosome 19 contains the neurotrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins. (PubMed id 1496419)1, 3, 9 Berkemeier L.R....Rosenthal A. (Somat. Cell Mol. Genet. 1992)
    5. No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma. (PubMed id 20215012)1, 2 Liu Y.... Hauser M.A. (Am. J. Hum. Genet. 2010)
    6. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (Autism Res 2009)
    7. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    8. Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders. (PubMed id 18203754)1, 4 Mercader J.M....Estivill X. (Hum. Mol. Genet. 2008)
    9. Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. (PubMed id 18179783)1, 4 RibasAcs M....BayAcs M. (Biol. Psychiatry 2008)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 4909 HGNC: 8024 AceView: NTF5 Ensembl:ENSG00000225950 euGenes: HUgn4909
    ECgene: NTF4 Kegg: 4909 H-InvDB: NTF4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NTF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NTF4 gene:
    Search GeneIP for patents involving NTF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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