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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

NTF3 Gene

protein-coding GIFtS: 68
GCID: GC12P005541

neurotrophin 3

Explore 92 diseases affiliated with
NTF3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Neurotrophin 3¹ ²		NGF-2² ³
NGF2¹ ²		NT-3² ³
Nerve Growth Factor 2² ³		NT3²
Neurotrophic Factor² ³		Neurotrophin-3¹
HDNF² ³

External Ids:	HGNC: 8023¹	Entrez Gene: 4908²	Ensembl: ENSG00000185652⁷	OMIM: 162660⁵	UniProtKB: P20783³

Export aliases for NTF3 gene to outside databases

Previous GC identifers: GC12U990064 GC12P005487 GC12P005420 GC12P005473

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTF3:

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of

mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor.

It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo

when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement

defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig,

rat and mouse. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783

Function: Seems to promote the survival of visceral and proprioceptive sensory neurons

Gene Wiki entry for NTF3 (Neurotrophin-3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009759.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NTF3 gene promoter:
GR CREB AP-1 deltaCREB ATF-2 GR-alpha c-Jun LyF-1 c-Ets-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NTF3 promoter sequence

Search SABiosciences Chromatin IP Primers for NTF3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NTF3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13

NTF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTF3 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P005541: view genomic region (about GC identifiers)

Start:	5,541,278 bp from pter	End:	5,630,702 bp from pter
Size:	89,425 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783 (See protein sequence)

Recommended Name: Neurotrophin-3 precursor

Size: 257 amino acids; 29355 Da

Subcellular location: Secreted

4 PDB 3D structures from and Proteopedia for NTF3:

1B8K (3D)

1BND (3D)

1NT3 (3D)

3BUK (3D)

Secondary accessions: B7Z1T5 Q6FH50

Alternative splicing: 2 isoforms: P20783-1 P20783-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NTF3: NX_P20783

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P20783

NTF3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001096124.1 NP_002518.1

ENSEMBL proteins:

ENSP00000397297 ENSP00000328738

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant NTF3 Protein
	R&D Systems Recombinant & Natural Proteins for NTF3 (NT-3)
	Enzo Life Sciences proteins for NTF3
	OriGene Purified Protein: NTF3 OriGene Protein Over-expression Lysate (see all 2): NTF3 OriGene Custom Protein Services for NTF3
	GenScript Custom Purified and Recombinant Proteins Services for NTF3
	Novus Biologicals NTF3 Proteins Novus Biologicals NTF3 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for NTF3
	Uscn Proteins for NTF3

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	--	--
GO:0016023	cytoplasmic membrane-bounded vesicle	IEA	--

NTF3 for ontologies About GeneDecksing

NTF3 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of NTF3
	R&D Systems Antibodies for NTF3 (NT-3)
	OriGene Antibodies (see all 4): NTF3 OriGene Custom Antibody Services for NTF3
	GenScript Custom Superior Antibodies Services for NTF3
	Novus Biologicals NTF3 Antibodies
	Abcam antibodies for NTF3
	Uscn Antibodies for NTF3
	ThermoFisher Antibodies for NTF3

Assay Products for NTF3:

	EMD Millipore Kits and Assays for the Analysis of NTF3
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for NTF3 (NT-3)
	GenScript Custom Assay Services for NTF3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NTF3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NTF3 for domains About GeneDecksing

4 InterPro domains/families:

IPR002072 Nerve_growth_factor-rel

IPR019846 Nerve_growth_factor_CS

IPR020408 Nerve_growth_factor-like

IPR015578 Neurotrophin-3

Graphical View of Domain Structure for InterPro Entry P20783

ProtoNet protein and cluster: P20783

2 Blocks protein families:

IPB002072 Nerve growth factor

IPB002400 Growth factor cystine knot superfamily signature

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783

Similarity: Belongs to the NGF-beta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783

Function: Seems to promote the survival of visceral and proprioceptive sensory neurons

Genatlas biochemistry entry for NTF3:

neurotrophic factor (neurotrophin) 3,29.3kDa,ligand for NTRK3 (TRKC),expressed in retina and the anterior segment of

the developing eye

Summary:

NTF3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Motor neuron-like cells, Motor neuron-like and Interneuron-like cells (see all 4).

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTF3
		8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate NTF3 (see all 33):
		hsa-miR-548j hsa-miR-429 hsa-miR-3146 hsa-miR-548k hsa-miR-374a hsa-miR-548l hsa-miR-1183 hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: NTF3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTF3 (see all 7) OriGene shRNA RFP: NTF3 OriGene siRNA: NTF3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTF3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for NTF3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTF3 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTF3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NTF3 (NM_002527)
		Sino Biological Human cDNA Clone for NTF3
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTF3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTF3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NTF3
		Search LifeMap BioReagents cell lines for NTF3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTF3

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	2236018
GO:0005165	neurotrophin receptor binding	IEA	--
GO:0005515	protein binding	--	--
GO:0008083	growth factor activity	IDA	--
GO:0042056	chemoattractant activity	IDA	--

NTF3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for NTF3:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for NTF3: Ntf3^tm1Mpin Ntf3^tm1Par Ntf3^tm2.1Jae Ntf3^tm1Jae
11 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Ntf3):

behavior/neurological	cardiovascular system	growth/size	homeostasis/metabolism	mortality/aging
muscle	nervous system	normal	reproductive system	respiratory system
vision/eye

NTF3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Apoptotic Pathways in Synovial Fibroblasts

8/14 pathways (see all 14)
Apoptotic Pathways in Synovial Fibroblasts	1.00	ERK5 Signaling	0.61
p53 Mediated Apoptosis	0.84	eIF2 Pathway	0.60
Mitochondrial Apoptosis	0.73	Rac1 Pathway	0.58
Telomerase Components in Cell Signaling	0.72	Nuclear Receptor Activation by Vitamin-A	0.57

GPCR Pathway

GPCR Pathway	1.00	Estrogen Pathway	0.55
Ras Pathway	0.62	Pancreatic Adenocarcinoma	0.55
Breast Cancer Regulation by Stathmin1	0.58	Paxillin Interactions	0.53
NFAT in Immune Response	0.58

TGF-Beta Pathway

TGF-Beta Pathway	1.00	JNK Pathway	0.50
MAPK Family Pathway	0.60	Regulation of eIF4 and p70S6K	0.43
JAK-STAT Pathway	0.57

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Nanog in Mammalian ESC Pluripotency

	Nanog in Mammalian ESC Pluripotency	1.00			14-3-3 Induced Intracellular Signaling	0.59
	GSK3 Signaling	0.61			eNOS Signaling	0.48

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for NTF3

	Development Neurotrophin family signaling
	Development MAG-dependent inhibition of neurite outgrowth

1 R&D Systems Pathway for NTF3

TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

5/56 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for NTF3 (see all 56)

	Nuclear Receptor Activation by Vitamin-A
	Paxillin Interactions
	Telomerase Components in Cell Signaling
	Mitochondrial Apoptosis
	Molecular Mechanisms of Cancer

2 GeneGo (Thomson Reuters) Pathways for NTF3

	Development Neurotrophin family signaling
	Development MAG-dependent inhibition of neurite outgrowth

5 BioSystems Pathways for NTF3

	Integrated Pancreatic Cancer Pathway
	Integrated Pancreatic Cancer Pathway
	Trk receptor signaling mediated by the MAPK pathway
	Neurotrophic factor-mediated Trk receptor signaling
	p75(NTR)-mediated signaling

2 Kegg Pathways (Kegg details for NTF3):

	MAPK signaling pathway
	Neurotrophin signaling pathway

NTF3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NTF3

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/12 Interacting proteins for NTF3 (P20783^{1, 2, 3} ENSP00000397297⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BDNF	P23560¹^,²^,³, ENSP00000414303⁴	EBI-1025994,EBI-1026003 MINT-24751 I2D: score=4 STRING: ENSP00000414303
NGFR	P08138³, ENSP00000172229⁴	I2D: score=1 STRING: ENSP00000172229
NTRK3	Q16288³, ENSP00000354207⁴	I2D: score=3 STRING: ENSP00000354207
NTRK2	Q16620³, ENSP00000277120⁴	I2D: score=3 STRING: ENSP00000277120
NTRK1	P04629³, ENSP00000351486⁴	I2D: score=1 STRING: ENSP00000351486

About this table

Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000187	activation of MAPK activity	IDA	--
GO:0002092	positive regulation of receptor internalization	IDA	--
GO:0007165	signal transduction	TAS	2236018
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IDA	--
GO:0007267	cell-cell signaling	TAS	2236018

NTF3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

NTF3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NTF3
10/74 Novoseek chemical compound relationships for NTF3 gene (see all 74) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
k252a	77.7	14	9065506 (2), 9689129 (2), 10595705 (2), 19783665 (1) (see all 6)
tyrosine	69.8	126	8106527 (4), 1649702 (3), 1645620 (2), 15770067 (2) (see all 76)
ly294002	29.7	4	15797869 (1), 8756297 (1), 11238738 (1)
choline	27.4	7	9476208 (1), 7867750 (1), 11988020 (1), 11779407 (1) (see all 5)
retinoic acid	24.9	33	10051769 (5), 11520943 (4), 19428697 (3), 15869429 (1) (see all 9)
glutamate	20.5	10	11117506 (2), 12666655 (2), 9707630 (1), 10391433 (1) (see all 7)
anisomycin	20.1	1	19158291 (1)
quinolinic acid	13.3	3	10964490 (2), 8692996 (1)
2 chloroadenosine	12.5	1	7545019 (1)
bromodeoxyuridine	10.5	1	19796180 (1)

Search CenterWatch for drugs/clinical trials and news about NTF3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for NTF3 gene (2 alternative transcripts):

NM_001102654.1 NM_002527.4

Unigene Cluster for NTF3:

Neurotrophin 3

Hs.99171 [show with all ESTs]

Unigene Representative Sequence: NM_001102654

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000535299 ENST00000423158(uc001qnk.4) ENST00000543548 ENST00000544836

ENST00000541234 ENST00000331010(uc001qnl.4)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NTF3
		8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate NTF3 (see all 33):
		hsa-miR-548j hsa-miR-429 hsa-miR-3146 hsa-miR-548k hsa-miR-374a hsa-miR-548l hsa-miR-1183 hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: NTF3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NTF3 (see all 7) OriGene shRNA RFP: NTF3 OriGene siRNA: NTF3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NTF3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NTF3 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NTF3 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): NTF3 (NM_002527)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTF3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTF3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTF3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NTF3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTF3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTF3

Additional cDNA sequence:

AK293895.1 BC069773.1 BC107075.1 CR541906.1 X53655.1

3 DOTS entries:

DT.308620 DT.102821597 DT.99982565

5 AceView cDNA sequences:

AL552418 BU939830 X53655 AL575726 BX386364

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

NTF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGTTGTTT

About this image

NTF3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovigerous Cord

Ovarian Somatic Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor T36 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Primitive gut tube-like cells (A scalable, suspensi...)

See NTF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NTF3

SOURCE GeneReport for Unigene cluster: Hs.99171

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783

Tissue specificity: Brain and peripheral tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including NTF3 (see all 7):

Neurogenesis in human mouse rat

Growth Factors in human mouse rat

Multiple Sclerosis in human mouse rat

Neurotrophins & Receptors in human mouse rat

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NTF3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat NTF3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NTF3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NTF3

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTF3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for NTF3 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	NTF3¹	neurotrophin 3	78.89(n) 88.52(a)		428099 NM_001109762.1 NP_001103232.1
lizard (Anolis carolinensis)	Reptilia	B9TW27_ANOCA⁶	Neurotrophin-3 Fragment	74(a)	1 ↔ 1	5(81566674-81567183)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1074²	Xenopus laevis neurotrophin-3 mRNA, complete cds	76.84(n)		U27576.1
zebrafish (Danio rerio)	Actinopterygii	ntf3¹	neurotrophin 3	58.95(n) 56.86(a)		386825 XM_692353.4 XP_697445.4

ENSEMBL Gene Tree for NTF3 (if available)
TreeFam Gene Tree for NTF3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for NTF3 gene

NTF4² BDNF² NGF²

3 SIMAP similar genes for NTF3 using alignment to 1 protein entry: NTF3_HUMAN:

BDNF NTF4 NGF

NTF3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783

Polymorphism: Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of

schizophrenia. This does not seem to be the case

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184654307^1,2		--	5539602(+)	`CCACTA/GAAGGA`	1	--	us2k¹		0	--	--	--	--
rs1800598^1,2		--	5539746(+)	`CCCCCA/GGACTC`	1	--	us2k¹		0	--	--	--	--
rs192641496^1,2		--	5539803(+)	`CGGCCG/TGTTGG`	1	--	us2k¹		0	--	--	--	--
rs1800599^1,2	C,F,	--	5540045(+)	`AAGGGA/CTGAGG`	1	--	us2k¹		5		WA CSA NA EA	362
rs116047994^1,2	F,	--	5540084(+)	`GACTCG/AGGAAG`	1	--	us2k¹		1		WA	118
rs144853930^1,2		--	5540264(+)	`ATCTCC/TAAATA`	1	--	us2k¹		0	--	--	--	--
rs185667365^1,2		--	5540510(+)	`GCGATC/GCATCT`	1	--	us2k¹		0	--	--	--	--
rs71459947^1,2	C,	--	5540540(+)	`AAGCTC/GCCGCA`	1	--	us2k¹		2		NA	122
rs189173493^1,2		--	5540835(+)	`GCAGGA/CAAAGG`	1	--	us2k¹		0	--	--	--	--
rs7977605^1,2	C	--	5541128(+)	`AGGGCA/GGGGGG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for NTF3 (5541278 - 5630702 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NTF3
2 CNVs: 86156 75911
2 Indels: 101411 86157
Human Gene Mutation Database (HGMD): NTF3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NTF3 for disorders           About GeneDecksing

OMIM gene information: 162660    OMIM disorders: --

20/92 diseases for NTF3 (see all 92):    About MalaCards

charcot-marie-tooth disease charcot-marie-tooth disease type 1 charcot-marie-tooth disease type 1a spinal cord injury

relapsing-remitting multiple sclerosis attention deficit hyperactivity disorder retinol binding protein autonomic neuropathy

neuroaxonal dystrophy tooth disease temporal lobe epilepsy dry eye syndrome

diabetic autonomic neuropathy primitive neuroectodermal tumor idiopathic interstitial pneumonia diabetic polyneuropathy

neuronitis irritable bowel syndrome amyotrophic lateral sclerosis chronic obstructive pulmonary disease

3 diseases from the University of Copenhagen DISEASES database for NTF3:

Neurodegenerative disease Neuropathy Brain disease

10/64 Novoseek disease relationships for NTF3 gene (see all 64) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sensory neuropathy	50.1	1	8599726 (1)
diabetic neuropathies	49.9	17	9728960 (5), 12677448 (1), 12805110 (1), 8580713 (1) (see all 8)
neurodegenerative diseases	43.7	6	10961440 (1), 9639663 (1), 8819011 (1), 9836577 (1)
neuroaxonal dystrophies	38.3	2	10973596 (1), 11245210 (1)
diabetic polyneuropathy	37.1	2	9728960 (1)
neurodegeneration	36.2	5	10867782 (1), 8780007 (1), 10023126 (1), 10527802 (1)
medulloblastoma	29.2	6	9560008 (3), 11379821 (1), 15994942 (1)
neurological disorders	28.6	3	12753507 (1), 10391433 (1), 7838303 (1)
motor neuron disease	28.4	2	9212104 (1), 8752586 (1)
alzheimers disease	26.2	15	11156744 (2), 9116211 (2), 10867782 (1), 7955419 (1) (see all 8)

Genetic Association Database (GAD): NTF3
Human Genome Epidemiology (HuGE) Navigator: NTF3 (14 documents)

Export disorders for NTF3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for NTF3 gene, integrated from 9 sources (see all 695):
(articles sorted by number of sources associating them with NTF3)

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world of online information

Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. (PubMed id 1889806)^{1, 2, 3, 9} Maisonpierre P.C....Yancopoulos G.D. (1991)
Association of neurotrophin-3 gene variant with severe forms of schizophrenia. (PubMed id 7733919)^{1, 2, 4, 9} Hattori M. and Nanko S. (1995)
Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer. (PubMed id 7703225)^{1, 2, 9} Robinson R.C.... Jones E.Y. (1995)
Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder. (PubMed id 15365216)^{1, 4, 9} Tadokoro K....Kunugi H. (2004)
Cloning and expression of a cDNA encoding a novel human neurotrophic factor. (PubMed id 2365067)^{1, 2, 9} Kaisho Y.... Nakahama K. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia. (PubMed id 11920853)^{1, 4} Hattori M....Nanko S. (2002)
Failure to find associations of the CA repeat polymorphism in the first intron and the Gly-63/Glu-63 polymorphism of the neurotrophin-3 gene with schizophrenia. (PubMed id 8925252)^{1, 2} Arinami T.... Toru M. (1996)
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. (PubMed id 2025430)^{1, 2} Hallboeoek F.... Persson H. (1991)
Primary structure and biological activity of a novel human neurotrophic factor. (PubMed id 2344409)^{1, 2} Rosenthal A.... Winslow J.W. (1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4908	HGNC: 8023	AceView: NTF3	Ensembl:ENSG00000185652	euGenes: HUgn4908
ECgene: NTF3	Kegg: 4908	H-InvDB: NTF3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for NTF3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for NTF3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for NTF3 gene:
Search GeneIP for patents involving NTF3

GeneCards and IP:
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neurotrophin 3

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