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NTF3 Gene

protein-coding   GIFtS: 67
GCID: GC12P005541

Neurotrophin 3

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Neurotrophin 31 2     NT-32 3
Nerve Growth Factor 22 3     NGF22
Neurotrophic Factor2 3     NT32
HDNF2 3     neurotrophin-32
NGF-22 3     

External Ids:    HGNC: 80231   Entrez Gene: 49082   Ensembl: ENSG000001856527   OMIM: 1626605   UniProtKB: P207833   
ORGUL members:         

Export aliases for NTF3 gene to outside databases

Previous GC identifers: GC12U990064 GC12P005487 GC12P005420 GC12P005473


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NTF3 Gene:
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and
differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and
brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may
affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated
by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical
in all mammals examined including human, pig, rat and mouse. (provided by RefSeq, Jul 2008)

GeneCards Summary for NTF3 Gene:
NTF3 (neurotrophin 3) is a protein-coding gene. Diseases associated with NTF3 include viral meningitis, and diabetic polyneuropathy. GO annotations related to this gene include chemoattractant activity and receptor binding. An important paralog of this gene is NTF4.

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783
Function: Seems to promote the survival of visceral and proprioceptive sensory neurons

Gene Wiki entry for NTF3 (Neurotrophin-3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009759.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the NTF3 gene promoter:
         GR   CREB   AP-1   deltaCREB   ATF-2   GR-alpha   c-Jun   LyF-1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): NTF3 promoter sequence
   Search Chromatin IP Primers for NTF3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NTF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13

NTF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTF3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P005541:  view genomic region     (about GC identifiers)

Start:
5,541,278 bp from pter      End:
5,630,702 bp from pter
Size:
89,425 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783 (See protein sequence)
Recommended Name: Neurotrophin-3 precursor  
Size: 257 amino acids; 29355 Da
4 PDB 3D structures from and Proteopedia for NTF3:
1B8K (3D)        1BND (3D)        1NT3 (3D)        3BUK (3D)    
Secondary accessions: B7Z1T5 Q6FH50
Alternative splicing: 2 isoforms:  P20783-1   P20783-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NTF3: NX_P20783

Explore proteomics data for NTF3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NTF3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001096124.1  NP_002518.1  

    ENSEMBL proteins: 
     ENSP00000397297   ENSP00000328738  

    NTF3 Human Recombinant Protein Products:

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    Novus Biologicals NTF3 Lysates
    Sino Biological Recombinant Protein for NTF3
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    Browse Proteins at Cloud-Clone Corp.

    NTF3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of NTF3
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    Novus Biologicals NTF3 Antibodies
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    NTF3 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    4 InterPro protein domains:
     IPR002072 Nerve_growth_factor-rel
     IPR019846 Nerve_growth_factor_CS
     IPR020408 Nerve_growth_factor-like
     IPR015578 Neurotrophin-3

    Graphical View of Domain Structure for InterPro Entry P20783

    ProtoNet protein and cluster: P20783

    2 Blocks protein domains:
    IPB002072 Nerve growth factor
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783
    Similarity: Belongs to the NGF-beta family


    NTF3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NTF3_HUMAN, P20783
    Function: Seems to promote the survival of visceral and proprioceptive sensory neurons

         Genatlas biochemistry entry for NTF3:
    neurotrophic factor (neurotrophin) 3,29.3kDa,ligand for NTRK3 (TRKC),expressed in retina and the anterior segment
    of the developing eye

         Summary: 
    NTF3 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
          selected tissues (see all 4)      fully expand
    Spinal Cord: Oligodendrocyte-like cells, Motor neuron-like cells      fully expand to see all 7 cells
    Brain: Oligodendrocyte-like cells, Oligodendrocyte-like cells       fully expand to see all 5 cells

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS2236018
    GO:0005165neurotrophin receptor binding IEA--
    GO:0005515protein binding ----
    GO:0008083growth factor activity IDA--
    GO:0042056chemoattractant activity IDA--
         
    NTF3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NTF3:
     Increased gamma-H2AX phosphory 

         11 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Ntf3):
     behavior/neurological  cardiovascular system  growth/size/body  homeostasis/metabolism  mortality/aging 
     muscle  nervous system  normal  reproductive system  respiratory system 
     vision/eye 

    NTF3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for NTF3: Ntf3tm2.1Jae Ntf3tm1Par Ntf3tm1Mpin Ntf3tm1Jae

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NTF3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NTF3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NTF3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NTF3

    miRNA
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    miRTarBase miRNAs that target NTF3:
    hsa-mir-200c-3p (MIRT007095), hsa-mir-335-5p (MIRT019215)

    Block miRNA regulation of human, mouse, rat NTF3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NTF3 (see all 33):
    hsa-miR-548j hsa-miR-429 hsa-miR-3146 hsa-miR-548k hsa-miR-374a hsa-miR-548l hsa-miR-1183 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidNTF3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NTF3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): NTF3 (NM_002527)
    Sino Biological Human cDNA Clone for NTF3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NTF3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTF3

    Cell Line
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    In Situ Assay
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NTF3_HUMAN, P20783: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton2
    nucleus2
    endoplasmic reticulum1
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    NTF3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NTF3 About   (see all 22)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Development HGF signaling pathway
    Development Neurotrophin family signaling0.45
    Neurotrophin signaling pathway0.36
    2Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    Rac1 Pathway0.65
    Cellular Apoptosis Pathway0.85
    Glioma Invasiveness0.64
    Apoptotic Pathways in Synovial Fibroblasts0.84
    Actin-Based Motility by Rho Family GTPases0.62
    p53 Mediated Apoptosis0.84
    ERK5 Signaling0.61
    3GPCR Pathway
    Ras Pathway0.73
    Breast Cancer Regulation by Stathmin10.58
    Paxillin Interactions0.73
    NFAT in Immune Response0.58
    GPCR Pathway0.62
    Estrogen Pathway0.55
    Pancreatic Adenocarcinoma0.59
    4TGF-Beta Pathway
    TGF-Beta Pathway0.60
    JNK Pathway0.51
    MAPK Family Pathway0.60
    Regulation of eIF4 and p70S6K0.43
    JAK-STAT Pathway0.57
    5ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    ILK Signaling0.49
    MAPK Signaling0.58

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for NTF3
        TNF Superfamily - Human Ligand-Receptor Interactions & their Associated Functions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for NTF3 (see all 56)
        Nuclear Receptor Activation by Vitamin-A
    Paxillin Interactions
    Telomerase Components in Cell Signaling
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer

    2 GeneGo (Thomson Reuters) Pathways for NTF3
        Development Neurotrophin family signaling
    Development MAG-dependent inhibition of neurite outgrowth

    5 BioSystems Pathways for NTF3
        BDNF signaling pathway
    Integrated Pancreatic Cancer Pathway
    p75(NTR)-mediated signaling
    Neurotrophic factor-mediated Trk receptor signaling
    Trk receptor signaling mediated by the MAPK pathway



    2 Kegg Pathways  (Kegg details for NTF3):
        MAPK signaling pathway
    Neurotrophin signaling pathway


    NTF3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NTF3 (see all 7): 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Multiple Sclerosis in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for NTF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for NTF3 (P207831, 2, 3 ENSP000003972974) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BDNFP235601, 2, 3, ENSP000004143034EBI-1025994,EBI-1026003 MINT-24751 I2D: score=4 STRING: ENSP00000414303
    NGFRP081383, ENSP000001722294I2D: score=1 STRING: ENSP00000172229
    NTRK3Q162883, ENSP000003542074I2D: score=3 STRING: ENSP00000354207
    NTRK1P046293, ENSP000003514864I2D: score=1 STRING: ENSP00000351486
    NTRK2Q166203, ENSP000002771204I2D: score=3 STRING: ENSP00000277120
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000187activation of MAPK activity IDA--
    GO:0002092positive regulation of receptor internalization IDA--
    GO:0007165signal transduction TAS2236018
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway IDA--
    GO:0007267cell-cell signaling TAS2236018

    NTF3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NTF3

    Selected Novoseek inferred chemical compound relationships for NTF3 gene (see all 74)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    k252a 77.7 14 9065506 (2), 9689129 (2), 10595705 (2), 19783665 (1) (see all 6)
    tyrosine 69.8 126 8106527 (4), 1649702 (3), 1645620 (2), 15770067 (2) (see all 76)
    ly294002 29.7 4 15797869 (1), 8756297 (1), 11238738 (1)
    choline 27.4 7 9476208 (1), 7867750 (1), 11988020 (1), 11779407 (1) (see all 5)
    retinoic acid 24.9 33 10051769 (5), 11520943 (4), 19428697 (3), 15869429 (1) (see all 9)
    glutamate 20.5 10 11117506 (2), 12666655 (2), 9707630 (1), 10391433 (1) (see all 7)
    anisomycin 20.1 1 19158291 (1)
    quinolinic acid 13.3 3 10964490 (2), 8692996 (1)
    2 chloroadenosine 12.5 1 7545019 (1)
    bromodeoxyuridine 10.5 1 19796180 (1)



    NTF3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NTF3 gene (2 alternative transcripts): 
    NM_001102654.1  NM_002527.4  

    Unigene Cluster for NTF3:

    Neurotrophin 3
    Hs.99171  [show with all ESTs]
    Unigene Representative Sequence: NM_001102654
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000535299 ENST00000423158(uc001qnk.4) ENST00000543548 ENST00000544836
    ENST00000541234 ENST00000331010(uc001qnl.4)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate NTF3 (see all 33):
    hsa-miR-548j hsa-miR-429 hsa-miR-3146 hsa-miR-548k hsa-miR-374a hsa-miR-548l hsa-miR-1183 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidNTF3 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 2): NTF3 (NM_002527)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NTF3
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      QuantiTect SYBR Green Assays in human, mouse, rat NTF3
      QuantiFast Probe-based Assays in human, mouse, rat NTF3

    Additional mRNA sequence: 

    AK293895.1 BC069773.1 BC107075.1 CR541906.1 X53655.1 

    3 DOTS entries:

    DT.308620  DT.102821597  DT.99982565 

    5 AceView cDNA sequences:

    X53655 AL552418 BU939830 BX386364 AL575726 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NTF3 expression in normal human tissues (normalized intensities)      NTF3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGTTGTTT
    NTF3 Expression
    About this image


    NTF3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
             Floor plate-like cells
     
     Peripheral Nervous System (Nervous System)
             Schwann-like cells
     
     Neurons
             Motor neuron progenitor cells
     
     Spinal Cord (Nervous System)
             Motor neuron progenitor cells
     
     Brain (Nervous System)
             Cerebral Cortex
    NTF3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NTF3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99171

    UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783
    Tissue specificity: Brain and peripheral tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including NTF3 (see all 7): 
              Neurogenesis in human mouse rat
              Growth Factors in human mouse rat
              Multiple Sclerosis in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat NTF3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NTF3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for NTF3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ntf31 , 5 neurotrophin 31, 5 90(n)1
    95.93(a)1
      6 (60.45 cM)5
    182051  NM_001164035.11  NP_001157507.11 
     1261014135 
    chicken
    (Gallus gallus)
    Aves NTF31 neurotrophin 3 78.89(n)
    88.52(a)
      428099  NM_001109762.1  NP_001103232.1 
    lizard
    (Anolis carolinensis)
    Reptilia NTF36
    Uncharacterized protein
    77(a)
    1 ↔ 1
    5(81509242-81569258)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.10742 Xenopus laevis neurotrophin-3 mRNA, complete cds 76.84(n)    U27576.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ntf31 neurotrophin 3 59.48(n)
    58.04(a)
      386825  XM_692353.5  XP_697445.5 


    ENSEMBL Gene Tree for NTF3 (if available)
    TreeFam Gene Tree for NTF3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NTF3 gene
    NTF42  BDNF2  NGF2  
    3 SIMAP similar genes for NTF3 using alignment to 1 protein entry:     NTF3_HUMAN:
    BDNF    NTF4    NGF

    NTF3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    NTF3_HUMAN, P20783: Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of
    schizophrenia. This does not seem to be the case


    Selected SNPs for NTF3 (see all 1281)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846543071,2
    --5539602(+) CCACTA/GAAGGA 1 -- us2k10--------
    rs18005981,2
    --5539746(+) CCCCCA/GGACTC 1 -- us2k10--------
    rs1926414961,2
    --5539803(+) CGGCCG/TGTTGG 1 -- us2k10--------
    rs18005991,2
    C,F--5540045(+) AAGGGA/CTGAGG 1 -- us2k15Minor allele frequency- C:0.07WA CSA NA EA 362
    rs1160479941,2
    F--5540084(+) GACTCG/AGGAAG 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1448539301,2
    C--5540264(+) ATCTCC/TAAATA 1 -- us2k10--------
    rs1856673651,2
    --5540510(+) GCGATC/GCATCT 1 -- us2k10--------
    rs714599471,2
    C,F--5540540(+) AAGCTC/GCCGCA 1 -- us2k12Minor allele frequency- G:0.11NA 122
    rs1891734931,2
    --5540835(+) GCAGGA/CAAAGG 1 -- us2k10--------
    rs79776051,2
    C--5541128(+) AGGGCA/GGGGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for NTF3 (5541278 - 5630702 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for NTF3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv513347CNV Insertion21212237
    nsv592CNV Insertion18451855
    esv2559368CNV Insertion19546169
    nsv524170CNV Gain19592680
    nsv523152CNV Gain19592680
    nsv470262CNV Gain18288195
    nsv898627CNV Gain21882294
    nsv468988CNV Gain19166990

    Human Gene Mutation Database (HGMD): NTF3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NTF3
    DNA2.0 Custom Variant and Variant Library Synthesis for NTF3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 162660    OMIM disorders: --

    Selected diseases for NTF3 (see all 88):    About MalaCards
    viral meningitis    diabetic polyneuropathy    diabetic neuropathy    meningitis and encephalitis
    hypochondriasis    diabetic autonomic neuropathy    ganglioneuroma    charcot-marie-tooth disease type 1a
    allergic encephalomyelitis    dry eye syndrome    neuroaxonal dystrophy    autonomic neuropathy
    charcot-marie-tooth disease type 1    idiopathic interstitial pneumonia    relapsing-remitting multiple sclerosis    meningitis
    bacterial meningitis    constipation    hydrocephalus    polyneuropathy

    3 diseases from the University of Copenhagen DISEASES database for NTF3:
    Neurodegenerative disease     Neuropathy     Brain disease

    NTF3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for NTF3 gene (see all 64)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sensory neuropathy 50.1 1 8599726 (1)
    diabetic neuropathies 49.9 17 9728960 (5), 12677448 (1), 12805110 (1), 8580713 (1) (see all 8)
    neurodegenerative diseases 43.7 6 10961440 (1), 9639663 (1), 8819011 (1), 9836577 (1)
    neuroaxonal dystrophies 38.3 2 10973596 (1), 11245210 (1)
    diabetic polyneuropathy 37.1 2 9728960 (1)
    neurodegeneration 36.2 5 10867782 (1), 8780007 (1), 10023126 (1), 10527802 (1)
    medulloblastoma 29.2 6 9560008 (3), 11379821 (1), 15994942 (1)
    neurological disorders 28.6 3 12753507 (1), 10391433 (1), 7838303 (1)
    motor neuron disease 28.4 2 9212104 (1), 8752586 (1)
    alzheimers disease 26.2 15 11156744 (2), 9116211 (2), 10867782 (1), 7955419 (1) (see all 8)

    Genetic Association Database (GAD): NTF3
    Human Genome Epidemiology (HuGE) Navigator: NTF3 (14 documents)

    Export disorders for NTF3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for NTF3 gene, integrated from 10 sources (see all 705):
    (articles sorted by number of sources associating them with NTF3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. (PubMed id 1889806)1, 2, 3, 9 Maisonpierre P.C....Yancopoulos G.D. (Genomics 1991)
    2. Association of neurotrophin-3 gene variant with severe forms of schizophrenia. (PubMed id 7733919)1, 2, 4, 9 Hattori M. and Nanko S. (Biochem. Biophys. Res. Commun. 1995)
    3. Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer. (PubMed id 7703225)1, 2, 9 Robinson R.C.... Jones E.Y. (Biochemistry 1995)
    4. Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. (PubMed id 18428117)1, 4, 9 Conner A.C....Thome J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    5. Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder. (PubMed id 15365216)1, 4, 9 Tadokoro K....Kunugi H. (Neuropsychobiology 2004)
    6. Cloning and expression of a cDNA encoding a novel human neurotrophic factor. (PubMed id 2365067)1, 2, 9 Kaisho Y.... Nakahama K. (FEBS Lett. 1990)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Neurotrophin-3 gene, intelligence, and selective attention deficit in a Korean sample with attention-deficit/hyperactivity disorder. (PubMed id 20576502)1, 4 Cho S.C....Son J.W. (amp 2010)
    9. Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease. (PubMed id 20219210)1, 4 GratacA^s M....Estivill X. (J Psychiatr Res 2010)
    10. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4908 HGNC: 8023 AceView: NTF3 Ensembl:ENSG00000185652 euGenes: HUgn4908
    ECgene: NTF3 Kegg: 4908 H-InvDB: NTF3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NTF3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NTF3 gene:
    Search GeneIP for patents involving NTF3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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