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Aliases for NTF3 Gene

Aliases for NTF3 Gene

  • Neurotrophin 3 2 3
  • Nerve Growth Factor 2 3 4
  • Neurotrophic Factor 3 4
  • NGF-2 3 4
  • HDNF 3 4
  • NT-3 3 4
  • Neurotrophin-3 3
  • NGF2 3
  • NT3 3

External Ids for NTF3 Gene

Previous GeneCards Identifiers for NTF3 Gene

  • GC12U990064
  • GC12P005487
  • GC12P005420
  • GC12P005473
  • GC12P005541

Summaries for NTF3 Gene

Entrez Gene Summary for NTF3 Gene

  • The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

GeneCards Summary for NTF3 Gene

NTF3 (Neurotrophin 3) is a Protein Coding gene. Diseases associated with NTF3 include hypochondriasis and diabetic polyneuropathy. Among its related pathways are MAPK signaling pathway and TGF-Beta Pathway. GO annotations related to this gene include receptor binding and chemoattractant activity. An important paralog of this gene is BDNF.

UniProtKB/Swiss-Prot for NTF3 Gene

  • Seems to promote the survival of visceral and proprioceptive sensory neurons

Gene Wiki entry for NTF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTF3 Gene

Genomics for NTF3 Gene

Regulatory Elements for NTF3 Gene

Genomic Location for NTF3 Gene

Start:
5,432,112 bp from pter
End:
5,521,536 bp from pter
Size:
89,425 bases
Orientation:
Plus strand

Genomic View for NTF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTF3 Gene

Proteins for NTF3 Gene

  • Protein details for NTF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20783-NTF3_HUMAN
    Recommended name:
    Neurotrophin-3
    Protein Accession:
    P20783
    Secondary Accessions:
    • B7Z1T5
    • Q6FH50

    Protein attributes for NTF3 Gene

    Size:
    257 amino acids
    Molecular mass:
    29355 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NTF3 Gene

    Alternative splice isoforms for NTF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NTF3 Gene

Proteomics data for NTF3 Gene at MOPED

Post-translational modifications for NTF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NTF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NTF3 Gene

Domains for NTF3 Gene

Gene Families for NTF3 Gene

HGNC:

Suggested Antigen Peptide Sequences for NTF3 Gene

Graphical View of Domain Structure for InterPro Entry

P20783

UniProtKB/Swiss-Prot:

NTF3_HUMAN :
  • P20783
Family:
  • Belongs to the NGF-beta family.
genes like me logo Genes that share domains with NTF3: view

Function for NTF3 Gene

Molecular function for NTF3 Gene

GENATLAS Biochemistry: neurotrophic factor (neurotrophin) 3,29.3kDa,ligand for NTRK3 (TRKC),expressed in retina and the anterior segment of the developing eye
UniProtKB/Swiss-Prot Function: Seems to promote the survival of visceral and proprioceptive sensory neurons

Gene Ontology (GO) - Molecular Function for NTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 2236018
GO:0005165 neurotrophin receptor binding --
GO:0005166 neurotrophin p75 receptor binding IBA --
GO:0005515 protein binding IPI 25416956
GO:0008083 growth factor activity IDA 23027130
genes like me logo Genes that share ontologies with NTF3: view
genes like me logo Genes that share phenotypes with NTF3: view

Animal Models for NTF3 Gene

MGI Knock Outs for NTF3:

miRNA for NTF3 Gene

miRTarBase miRNAs that target NTF3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NTF3 Gene

Localization for NTF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTF3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTF3 Gene COMPARTMENTS Subcellular localization image for NTF3 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
nucleus 2
endoplasmic reticulum 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IBA --
GO:0016023 cytoplasmic membrane-bounded vesicle IBA --
genes like me logo Genes that share ontologies with NTF3: view

Pathways for NTF3 Gene

genes like me logo Genes that share pathways with NTF3: view

Gene Ontology (GO) - Biological Process for NTF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IDA 23027130
GO:0002092 positive regulation of receptor internalization IDA 23027130
GO:0007165 signal transduction TAS 2236018
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA 23027130
GO:0007267 cell-cell signaling TAS 2236018
genes like me logo Genes that share ontologies with NTF3: view

Compounds for NTF3 Gene

(74) Novoseek inferred chemical compound relationships for NTF3 Gene

Compound -log(P) Hits PubMed IDs
k252a 77.7 9
tyrosine 69.8 89
ly294002 29.7 3
choline 27.4 5
retinoic acid 24.9 18
genes like me logo Genes that share compounds with NTF3: view

Transcripts for NTF3 Gene

mRNA/cDNA for NTF3 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NTF3 Gene

Neurotrophin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTF3 Gene

No ASD Table

Relevant External Links for NTF3 Gene

GeneLoc Exon Structure for
NTF3
ECgene alternative splicing isoforms for
NTF3

Expression for NTF3 Gene

mRNA expression in normal human tissues for NTF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NTF3 Gene

This gene is overexpressed in Artery - Tibial (8.1), Artery - Aorta (6.2), and Artery - Coronary (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NTF3 Gene

SOURCE GeneReport for Unigene cluster for NTF3 Gene Hs.99171

mRNA Expression by UniProt/SwissProt for NTF3 Gene

P20783-NTF3_HUMAN
Tissue specificity: Brain and peripheral tissues
genes like me logo Genes that share expressions with NTF3: view

Orthologs for NTF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NTF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTF3 35
  • 98.7 (n)
  • 98.83 (a)
NTF3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NTF3 35
  • 89.68 (n)
  • 96.43 (a)
NTF3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTF3 35
  • 92.1 (n)
  • 95.93 (a)
NTF3 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntf3 35
  • 90 (n)
  • 95.93 (a)
Ntf3 16
Ntf3 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTF3 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NT-3 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ntf3 35
  • 90.62 (n)
  • 95.93 (a)
chicken
(Gallus gallus)
Aves NTF3 35
  • 78.89 (n)
  • 88.52 (a)
NTF3 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTF3 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1074 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ntf3 35
  • 73.28 (n)
  • 81.32 (a)
Str.3752 35
zebrafish
(Danio rerio)
Actinopterygii ntf3 35
  • 59.48 (n)
  • 58.04 (a)
ntf3 36
  • 55 (a)
OneToOne
Species with no ortholog for NTF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTF3 Gene

ENSEMBL:
Gene Tree for NTF3 (if available)
TreeFam:
Gene Tree for NTF3 (if available)

Paralogs for NTF3 Gene

Paralogs for NTF3 Gene

Selected SIMAP similar genes for NTF3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NTF3: view

Variants for NTF3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for NTF3 Gene

P20783-NTF3_HUMAN
Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of schizophrenia. This does not seem to be the case

Sequence variations from dbSNP and Humsavar for NTF3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs6332 -- 5,494,466(+) CAGCC(A/G)GTGAT synonymous-codon, reference
rs918177 -- 5,443,895(-) TCTCT(C/T)GCCTC intron-variant
rs1549035 -- 5,451,732(-) gtcta(C/G)aagac intron-variant
rs1549036 -- 5,450,214(-) CAAAC(C/T)GTGTT intron-variant
rs1800598 -- 5,430,580(+) CCCCC(A/G)GACTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NTF3 Gene

Variant ID Type Subtype PubMed ID
nsv470262 CNV Gain 18288195
nsv468988 CNV Gain 19166990
nsv523152 CNV Gain 19592680
nsv592 CNV Insertion 18451855
nsv524170 CNV Gain 19592680
esv2559368 CNV Insertion 19546169
nsv513347 CNV Insertion 21212237
nsv898627 CNV Gain 21882294

Relevant External Links for NTF3 Gene

HapMap Linkage Disequilibrium report
NTF3
Human Gene Mutation Database (HGMD)
NTF3

Disorders for NTF3 Gene

(3) University of Copenhagen DISEASES for NTF3 Gene

(64) Novoseek inferred disease relationships for NTF3 Gene

Disease -log(P) Hits PubMed IDs
sensory neuropathy 50.1 1
diabetic neuropathies 49.9 12
neurodegenerative diseases 43.7 4
neuroaxonal dystrophies 38.3 2
diabetic polyneuropathy 37.1 1

Relevant External Links for NTF3

Genetic Association Database (GAD)
NTF3
Human Genome Epidemiology (HuGE) Navigator
NTF3
genes like me logo Genes that share disorders with NTF3: view

No data available for UniProtKB/Swiss-Prot for NTF3 Gene

Publications for NTF3 Gene

  1. Association of neurotrophin-3 gene variant with severe forms of schizophrenia. (PMID: 7733919) Hattori M. … Nanko S. (Biochem. Biophys. Res. Commun. 1995) 3 4 23 48
  2. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. (PMID: 1889806) Maisonpierre P.C. … Yancopoulos G.D. (Genomics 1991) 2 3 4 23
  3. Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder. (PMID: 15365216) Tadokoro K. … Kunugi H. (Neuropsychobiology 2004) 3 23 48
  4. Cloning and expression of a cDNA encoding a novel human neurotrophic factor. (PMID: 2365067) Kaisho Y. … Nakahama K. (FEBS Lett. 1990) 3 4 23
  5. Neurotrophin 3 is a mitogen for cultured neural crest cells. (PMID: 1542658) Kalcheim C. … Rosenthal A. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 23

Products for NTF3 Gene

Sources for NTF3 Gene

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