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Aliases for NTAN1 Gene

Aliases for NTAN1 Gene

  • N-Terminal Asparagine Amidase 2 3
  • Protein NH2-Terminal Asparagine Deamidase 3 4
  • Protein N-Terminal Asparagine Amidase 3 4
  • Protein N-Terminal Asn Amidase 3 4
  • Protein NTN-Amidase 3 4
  • PNAA 3 4
  • PNAD 3 4
  • Protein NH2-Terminal Asparagine Amidohydrolase 4
  • Protein N-Terminal Asparagine Amidohydrolase 3
  • EC 3.5.1.- 4

External Ids for NTAN1 Gene

Summaries for NTAN1 Gene

Entrez Gene Summary for NTAN1 Gene

  • The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for NTAN1 Gene

NTAN1 (N-Terminal Asparagine Amidase) is a Protein Coding gene. Diseases associated with NTAN1 include secondary progressive multiple sclerosis. GO annotations related to this gene include protein-N-terminal asparagine amidohydrolase activity.

UniProtKB/Swiss-Prot for NTAN1 Gene

  • Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NTAN1 Gene

Genomics for NTAN1 Gene

Genomic Location for NTAN1 Gene

Start:
15,037,853 bp from pter
End:
15,056,079 bp from pter
Size:
18,227 bases
Orientation:
Minus strand

Genomic View for NTAN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NTAN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NTAN1 Gene

Regulatory Elements for NTAN1 Gene

Proteins for NTAN1 Gene

  • Protein details for NTAN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AB6-NTAN1_HUMAN
    Recommended name:
    Protein N-terminal asparagine amidohydrolase
    Protein Accession:
    Q96AB6
    Secondary Accessions:
    • Q7Z4Z0

    Protein attributes for NTAN1 Gene

    Size:
    310 amino acids
    Molecular mass:
    34677 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for NTAN1 Gene

Proteomics data for NTAN1 Gene at MOPED

Post-translational modifications for NTAN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NTAN1 Gene

Domains for NTAN1 Gene

Protein Domains for NTAN1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with NTAN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NTAN1 Gene

Function for NTAN1 Gene

Molecular function for NTAN1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: pH dependence: Optimum pH is 6.0-7.5. {ECO:0000269 PubMed:21375249};
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by micromolar concentrations of copper and zinc ions.
UniProtKB/Swiss-Prot Function: Side-chain deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. This enzyme does not act on substrates with internal or C-terminal asparagines and does not act on glutamine residues in any position, nor on acetylated N-terminal peptidyl Asn.

Enzyme Numbers (IUBMB) for NTAN1 Gene

Gene Ontology (GO) - Molecular Function for NTAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008418 protein-N-terminal asparagine amidohydrolase activity IEA --
genes like me logo Genes that share ontologies with NTAN1: view
genes like me logo Genes that share phenotypes with NTAN1: view

Animal Models for NTAN1 Gene

MGI Knock Outs for NTAN1:

miRNA for NTAN1 Gene

miRTarBase miRNAs that target NTAN1

No data available for Transcription Factor Targeting and HOMER Transcription for NTAN1 Gene

Localization for NTAN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NTAN1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NTAN1 Gene COMPARTMENTS Subcellular localization image for NTAN1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NTAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NTAN1: view

Pathways for NTAN1 Gene

SuperPathways for NTAN1 Gene

No Data Available

Interacting Proteins for NTAN1 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000287706%0d%0a9606.ENSP00000382177%0d%0a9606.ENSP00000261839%0d%0a9606.ENSP00000285039%0d%0a9606.ENSP00000366819%0d%0a9606.ENSP00000226209%0d%0a
Selected Interacting proteins: ENSP00000287706 Q96AB6-NTAN1_HUMAN for NTAN1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NTAN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007613 memory IEA --
GO:0008152 metabolic process IEA --
GO:0008344 adult locomotory behavior IEA --
genes like me logo Genes that share ontologies with NTAN1: view

No data available for Pathways by source for NTAN1 Gene

Compounds for NTAN1 Gene

(1) Novoseek inferred chemical compound relationships for NTAN1 Gene

Compound -log(P) Hits PubMed IDs
rantes 35.3 2
genes like me logo Genes that share compounds with NTAN1: view

Transcripts for NTAN1 Gene

Unigene Clusters for NTAN1 Gene

N-terminal asparagine amidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NTAN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b
SP1: -
SP2: - -
SP3:

Relevant External Links for NTAN1 Gene

GeneLoc Exon Structure for
NTAN1
ECgene alternative splicing isoforms for
NTAN1

Expression for NTAN1 Gene

mRNA expression in normal human tissues for NTAN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NTAN1 Gene

SOURCE GeneReport for Unigene cluster for NTAN1 Gene Hs.592045

genes like me logo Genes that share expressions with NTAN1: view

Orthologs for NTAN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NTAN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NTAN1 36
  • 99.14 (n)
  • 99.03 (a)
NTAN1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NTAN1 36
  • 91.94 (n)
  • 94.19 (a)
NTAN1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NTAN1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ntan1 36
  • 89.25 (n)
  • 92.26 (a)
Ntan1 16
Ntan1 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NTAN1 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 69 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ntan1 36
  • 89.1 (n)
  • 91.91 (a)
chicken
(Gallus gallus)
Aves NTAN1 36
  • 71.23 (n)
  • 69.06 (a)
NTAN1 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NTAN1 37
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ntan1 36
  • 64.5 (n)
  • 59.28 (a)
Str.2432 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5805 36
zebrafish
(Danio rerio)
Actinopterygii ntan1 36
  • 53.49 (n)
  • 44.19 (a)
ntan1 37
  • 39 (a)
OneToOne
zgc77869 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010963 36
  • 49.18 (n)
  • 43.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta SP2637 36
  • 47.21 (n)
  • 39.25 (a)
SP2637 37
  • 37 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G44420 36
  • 45.98 (n)
  • 32.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToOne
Species with no ortholog for NTAN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NTAN1 Gene

ENSEMBL:
Gene Tree for NTAN1 (if available)
TreeFam:
Gene Tree for NTAN1 (if available)

Paralogs for NTAN1 Gene

Selected SIMAP similar genes for NTAN1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for NTAN1 Gene

genes like me logo Genes that share paralogs with NTAN1: view

No data available for Paralogs for NTAN1 Gene

Variants for NTAN1 Gene

Sequence variations from dbSNP and Humsavar for NTAN1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_051244 -
VAR_051245 -

Structural Variations from Database of Genomic Variants (DGV) for NTAN1 Gene

Variant ID Type Subtype PubMed ID
dgv811e1 CNV Complex 17122850
dgv812e1 CNV Complex 17122850
nsv511045 OTHER Complex 20534489
nsv7277 OTHER Inversion 18451855
dgv813e1 CNV Complex 17122850
nsv905361 CNV Gain 21882294
dgv814e1 CNV Complex 17122850
essv12354 CNV CNV 17122850
nsv905369 CNV Loss 21882294
dgv2606n71 CNV Loss 21882294
dgv2607n71 CNV Gain 21882294
nsv905374 CNV Gain 21882294
dgv2608n71 CNV Loss 21882294
nsv905377 CNV Gain 21882294
nsv905380 CNV Gain 21882294
nsv509598 CNV Insertion 20534489
dgv344n27 CNV Loss 19166990
nsv457426 CNV Gain 19166990
dgv815e1 CNV Complex 17122850

Relevant External Links for NTAN1 Gene

HapMap Linkage Disequilibrium report
NTAN1
Human Gene Mutation Database (HGMD)
NTAN1

Disorders for NTAN1 Gene

(1) University of Copenhagen DISEASES for NTAN1 Gene

(2) Novoseek inferred disease relationships for NTAN1 Gene

Disease -log(P) Hits PubMed IDs
inflammation 31.2 5
arthritis 7.33 3

Relevant External Links for NTAN1

Genetic Association Database (GAD)
NTAN1
Human Genome Epidemiology (HuGE) Navigator
NTAN1
genes like me logo Genes that share disorders with NTAN1: view

No data available for UniProtKB/Swiss-Prot for NTAN1 Gene

Publications for NTAN1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia. (PMID: 18496130) Kamdem L.K. … Relling M.V. (Pharmacogenet. Genomics 2008) 3 49
  3. Copy number variations of chromosome 16p13.1 region associated with schizophrenia. (PMID: 19786961) Ingason A. … St Clair D.M. (Mol. Psychiatry 2011) 3 49
  4. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y. … Kamatani N. (Hum. Mol. Genet. 2010) 3 49
  5. Expression and biochemical characterization of the human enzyme N-terminal asparagine amidohydrolase. (PMID: 21375249) Cantor J.R. … Georgiou G. (Biochemistry 2011) 3 4

Products for NTAN1 Gene

Sources for NTAN1 Gene

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