Aliases for NT5M Gene
External Ids for NT5M Gene
Previous GeneCards Identifiers for NT5M Gene
This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the 5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
GeneCards Summary for NT5M Gene
NT5M (5',3'-Nucleotidase, Mitochondrial) is a Protein Coding gene. Diseases associated with NT5M include Adiaspiromycosis and Ametropic Amblyopia. Among its related pathways are NAD metabolism and Purine metabolism (KEGG). GO annotations related to this gene include nucleotide binding and nucleotidase activity. An important paralog of this gene is NT5C.
UniProtKB/Swiss-Prot for NT5M Gene
Dephosphorylates specifically the 5 and 2(3)-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.