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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NT5M Gene

protein-coding   GIFtS: 59
GCID: GC17P017206

5',3'-Nucleotidase, Mitochondrial

(Previous names: 5' nucleotidase, mitochondrial)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
5',3'-Nucleotidase, Mitochondrial1 2 3     5(3)-deoxyribonucleotidase2
5' Nucleotidase, Mitochondrial1 2     dNT22
Deoxy-5'-Nucleotidase 22 3     mdN2
dNT-22 3     Mitochondrial 5' Nucleotidase2
DNT23 5     EC 3.1.3.-3
5'(3')-Deoxyribonucleotidase, Mitochondrial2     EC 3.1.38

External Ids:    HGNC: 157691   Entrez Gene: 569532   Ensembl: ENSG000002053097   OMIM: 6052925   UniProtKB: Q9NPB13   

Export aliases for NT5M gene to outside databases

Previous GC identifers: GC17P017521 GC17P018565 GC17P017149 GC17P017407 GC17P017147 GC17P016959


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NT5M Gene:
This gene encodes a 5' nucleotidase that localizes to the mitochondrial matrix. This enzyme dephosphorylates the
5'- and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides. The gene is located within the
Smith-Magenis syndrome region on chromosome 17. (provided by RefSeq, Jul 2008)

GeneCards Summary for NT5M Gene: 
NT5M (5',3'-nucleotidase, mitochondrial) is a protein-coding gene. Diseases associated with NT5M include dentin sensitivity, and nevoid basal cell carcinoma syndrome, and among its related super-pathways are NAD metabolism and Metabolic pathways. GO annotations related to this gene include nucleotidase activity and nucleotide binding. An important paralog of this gene is NT5C.

UniProtKB/Swiss-Prot: NT5M_HUMAN, Q9NPB1
Function: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides,
and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NT5M gene promoter:
         E2F-4   E2F-3a   E2F-5   p53   POU3F1   E2F-2   CUTL1   E2F   E2F-1   GCNF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for NT5M

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NT5M


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

NT5M Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NT5M gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P017206:  view genomic region     (about GC identifiers)

Start:
17,206,649 bp from pter      End:
17,250,977 bp from pter
Size:
44,329 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NT5M_HUMAN, Q9NPB1 (See protein sequence)
Recommended Name: 5'(3')-deoxyribonucleotidase, mitochondrial precursor  
Size: 228 amino acids; 25862 Da
Cofactor: Magnesium
Subunit: Homodimer (Probable)
Subcellular location: Mitochondrion
6/12 PDB 3D structures from and Proteopedia for NT5M (see all 12):
1MH9 (3D)        1Q91 (3D)        1Q92 (3D)        1Z4I (3D)        1Z4J (3D)        1Z4K (3D)    

Explore the universe of human proteins at neXtProt for NT5M: NX_Q9NPB1

Explore proteomics data for NT5M at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPB1

  • 2 DME Specific Peptides for NT5M (Q9NPB1)
     GVLADFE  DLLIDDRP 

    NT5M Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NT5M Protein Expression
    REFSEQ proteins: NP_064586.1  
    ENSEMBL proteins: 
     ENSP00000373674   ENSP00000464303   ENSP00000463674   ENSP00000467567  
    Reactome Protein details: Q9NPB1
    Human Recombinant Protein Products for NT5M: 
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    Novus Biologicals NT5M Proteins
    Novus Biologicals NT5M Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for NT5M
    Cloud-Clone Corp. Proteins for NT5M 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion TAS10899995
    GO:0005759mitochondrial matrix TAS--

    NT5M for ontologies           About GeneDecksing



    NT5M Antibody Products: 
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    Assay Products for NT5M: 
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    Cloud-Clone Corp. ELISAs for NT5M 
    Cloud-Clone Corp. CLIAs for NT5M


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Mitochondrial 5a-nucleotidase 
    Adenosine turnover

    2 InterPro protein domains:
     IPR010708 5'(3')-deoxyribonucleotidase
     IPR023214 HAD-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NPB1

    ProtoNet protein and cluster: Q9NPB1

    1 Blocks protein domain: IPB010708 5 nucleotidase

    UniProtKB/Swiss-Prot: NT5M_HUMAN, Q9NPB1
    Similarity: Belongs to the 5'(3')-deoxyribonucleotidase family


    NT5M for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NT5M_HUMAN, Q9NPB1
    Function: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides,
    and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP

         Enzyme Numbers (IUBMB): EC 3.1.32 EC 3.1.3.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0008252nucleotidase activity TAS10899995
    GO:00082535'-nucleotidase activity EXP--
    GO:0016791phosphatase activity ----
    GO:0046872metal ion binding IEA--
         
    NT5M for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NT5M 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NT5M

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NT5M 
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    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NT5M:
    hsa-miR-4310 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidNT5M 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for NT5M About                                                                                                See pathways by source

    SuperPathContained pathways About
    1NAD metabolism
    NAD metabolism0.43
    Nicotinate and nicotinamide metabolism0.43
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Pyrimidine metabolism
    Pyrimidine metabolism0.50
    Pyrimidine catabolism0.50
    4Purine metabolism
    Purine metabolism0.38
    Pyrimidine metabolism0.38
    5Purine metabolism
    Metabolism of nucleotides0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for NT5M
        NAD metabolism


    1 GeneGo (Thomson Reuters) Pathway for NT5M
        NAD metabolism

    4        Reactome Pathways for NT5M
        Metabolism of nucleotides
    Metabolism
    Pyrimidine catabolism
    Pyrimidine metabolism


    4         Kegg Pathways  (Kegg details for NT5M):
        Purine metabolism
    Pyrimidine metabolism
    Nicotinate and nicotinamide metabolism
    Metabolic pathways


    NT5M for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NT5M

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/76 Interacting proteins for NT5M (ENSP000003736744) via UniProtKB, MINT, STRING, and/or I2D (see all 76)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AK2ENSP000003469214STRING: ENSP00000346921
    ATICENSP000002369594STRING: ENSP00000236959
    CDAENSP000003642124STRING: ENSP00000364212
    CMPK1ENSP000003609394STRING: ENSP00000360939
    CMPK2ENSP000002567224STRING: ENSP00000256722
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0006260DNA replication TAS10899995
    GO:0009223pyrimidine deoxyribonucleotide catabolic process TAS10899995
    GO:0044281small molecule metabolic process TAS--
    GO:0046079dUMP catabolic process IEA--

    NT5M for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    NT5M for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NT5M

    10/29 HMDB Compounds for NT5M (see all 29)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2'-Deoxyguanosine 5'-monophosphate2'-Deoxy-5'-GMP (see all 21)902-04-5--
    5-Thymidylic acid2'-Deoxythymidine 5'-monophosphate (see all 28)365-07-1--
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Deoxyadenosine1-(6-amino-9H-purin-9-yl)-1,2-dideoxy-b-D-Ribofuranose (see all 22)958-09-8--
    Deoxyadenosine monophosphate2'-Deoxy-5'-adenylate (see all 24)653-63-4--
    Deoxycytidine1-(2-Deoxy-b-D-ribofuranosyl)cytosine (see all 15)951-77-9--
    Deoxyguanosine2'-Deoxyguanosine (see all 11)961-07-9--

    2 DrugBank Compounds for NT5M    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Dpb-T-- --target--17139284 17016423 10592235
    cyclic 3',5'-thymidine monophosphate2',3'-dehydro-2',3'-deoxy-thymidine 5'-monophosphate (see all 7)--target--10592235

    1 Novoseek inferred chemical compound relationship for NT5M gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thymidine 46 7 14747464 (3), 12352955 (1), 15044615 (1)

    Search CenterWatch for drugs/clinical trials and news about NT5M

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NT5M gene: 
    NM_020201.3  

    Unigene Cluster for NT5M:

    5',3'-nucleotidase, mitochondrial
    Hs.513977  [show with all ESTs]
    Unigene Representative Sequence: NM_020201
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389022(uc002grf.3 uc002grg.3) ENST00000478373 ENST00000470418
    ENST00000483704 ENST00000582909 ENST00000480529
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate NT5M:
    hsa-miR-4310 hsa-miR-1207-5p
    SwitchGear 3'UTR luciferase reporter plasmidNT5M 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NT5M

    Additional mRNA sequence: 

    AF210652.1 BC035838.1 DQ323995.1 

    4 DOTS entries:

    DT.442499  DT.100739089  DT.75117837  DT.99938163 

    24/49 AceView cDNA sequences (see all 49):

    AI085646 NM_020201 BQ933896 BI255109 BC035838 BQ943179 CR602400 BF431576 
    BU620529 BG819613 BF528105 AL514954 BM798008 AA323580 AL526310 AI567143 
    AF210652 BM547741 AW272329 AW137930 AA774519 BQ943423 AI125461 BF592121 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NT5M expression in normal human tissues (normalized intensities)      NT5M embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NT5M Expression
    About this image


    NT5M expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
             ganglion/cranial   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Lower Urinary Tract (Urinary System)
             visceral organ   
     
     Hair (Integumentary System)
             mouse/organ system/integumental system   

    See NT5M Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NT5M

    SOURCE GeneReport for Unigene cluster: Hs.513977

    UniProtKB/Swiss-Prot: NT5M_HUMAN, Q9NPB1
    Tissue specificity: Highly expressed in heart, brain and skeletal muscle. Detected at very low levels in kidney
    and pancreas

        SABiosciences Custom PCR Arrays for NT5M
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5M

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NT5M gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nt5m1 , 5 5',3'-nucleotidase, mitochondrial1, 5 87.92(n)1
    88.07(a)1
      11 (37.80 cM)5
    1038501  NM_134029.21  NP_598790.11 
     598394475 
    chicken
    (Gallus gallus)
    Aves NT5M1 5',3'-nucleotidase, mitochondrial 77.83(n)
    82.08(a)
      416505  XM_414809.3  XP_414809.2 
    lizard
    (Anolis carolinensis)
    Reptilia NT5M6
    5',3'-nucleotidase, mitochondrial
    73(a)
    1 ↔ 1
    GL343500.1(349090-359564)


    ENSEMBL Gene Tree for NT5M (if available)
    TreeFam Gene Tree for NT5M (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NT5M gene
    NT5C2  
    1 SIMAP similar gene for NT5M using alignment to 4 protein entries:     NT5M_HUMAN (see all proteins):
    NT5C

    NT5M for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/984 SNPs in NT5M are shown (see all 984)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs350392031,2
    C,F--17204715(+) CCAATC/GAGCAC 1 -- us2k14Minor allele frequency- G:0.09NA 126
    rs1868467171,2
    --17204823(+) CTACCC/TTTTCT 1 -- us2k10--------
    rs1916876381,2
    --17205022(+) CCCCAG/TTCTTC 1 -- us2k10--------
    rs1442939341,2
    C--17205061(+) GCCAAA/GTGGTG 1 -- us2k10--------
    rs1823664281,2
    --17205141(+) CGAGGC/GGGGTG 1 -- us2k10--------
    rs1854931071,2
    --17205235(+) GCCGGC/GTGCGG 1 -- us2k10--------
    rs1163574771,2
    C,F--17205740(+) CGGTGA/GCCTAC 1 -- us2k11Minor allele frequency- G:0.07WA 118
    rs1896707881,2
    --17205769(+) AGGAGA/GGTGAG 1 -- us2k10--------
    rs791936991,2
    C,F--17205788(+) AACTAC/GCTATC 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1170810611,2
    C,F--17205860(+) TTTATA/GTAACA 1 -- us2k11Minor allele frequency- G:0.03EA 120

    HapMap Linkage Disequilibrium report for NT5M (17206649 - 17250977 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for NT5M (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715717CNV Deletion23290073
    esv2659771CNV Deletion23128226
    esv2673352CNV Deletion23128226
    esv2813CNV Deletion18987735
    esv5295CNV Deletion18987735
    esv2715719CNV Deletion23290073
    esv2715720CNV Deletion23290073
    esv2715716CNV Deletion23290073
    esv1198553CNV Deletion17803354
    esv6568CNV Loss19470904

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605292    OMIM disorders: --

    6 diseases for NT5M:    About MalaCards
    dentin sensitivity    nevoid basal cell carcinoma syndrome    smith magenis syndrome    basal cell carcinoma
    periodontal disease    periodontitis

    1 disease from the University of Copenhagen DISEASES database for NT5M:
    Dentin sensitivity

    NT5M for disorders           About GeneDecksing

    Genetic Association Database (GAD): NT5M
    Human Genome Epidemiology (HuGE) Navigator: NT5M (1 document)

    Export disorders for NT5M gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NT5M gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with NT5M)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease. (PubMed id 10899995)1, 2, 3 Rampazzo C....Bianchi V. (2000)
    2. Crystal structure of a human mitochondrial deoxyribonucleotidase. (PubMed id 12352955)1, 2, 9 Rinaldo-Matthis A.... Nordlund P. (2002)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human mitochondrial 5'-deoxyribonucleotidase. Overproduction in cultured cells and functional aspects. (PubMed id 12124385)1, 9 Gallinaro L....Bianchi V. (2002)
    6. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    7. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    8. Structural basis for substrate specificity of the human mitochondrial deoxyribonucleotidase. (PubMed id 16004879)1 Wallden K....Nordlund P. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56953 HGNC: 15769 AceView: NT5M Ensembl:ENSG00000205309 euGenes: HUgn56953
    ECgene: NT5M Kegg: 56953 H-InvDB: NT5M

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NT5M Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NT5M gene:
    Search GeneIP for patents involving NT5M

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 27 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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