Aliases for NT5E Gene
External Ids for NT5E Gene
Previous HGNC Symbols for NT5E Gene
Previous GeneCards Identifiers for NT5E Gene
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
GeneCards Summary for NT5E Gene
NT5E (5'-Nucleotidase, Ecto (CD73)) is a Protein Coding gene. Diseases associated with NT5E include hereditary arterial and articular multiple calcification syndrome and calcification of joints and arteries. Among its related pathways are Metabolism and HIF-1-alpha transcription factor network. GO annotations related to this gene include nucleotide binding and hydrolase activity, acting on ester bonds.
UniProtKB/Swiss-Prot for NT5E Gene
Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.