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Aliases for NT5DC4 Gene

Aliases for NT5DC4 Gene

  • 5'-Nucleotidase Domain Containing 4 2
  • 5-Nucleotidase Domain Containing 4 2 3
  • EC 63

External Ids for NT5DC4 Gene

Previous GeneCards Identifiers for NT5DC4 Gene

  • GC02U900803
  • GC02P113196
  • GC02P113465
  • GC02P105933

Summaries for NT5DC4 Gene

GeneCards Summary for NT5DC4 Gene

NT5DC4 (5'-Nucleotidase Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and 5-nucleotidase activity. An important paralog of this gene is NT5DC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5DC4 Gene

Genomics for NT5DC4 Gene

Regulatory Elements for NT5DC4 Gene

Genomic Location for NT5DC4 Gene

112,720,810 bp from pter
112,742,879 bp from pter
22,070 bases
Plus strand

Genomic View for NT5DC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NT5DC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5DC4 Gene

Proteins for NT5DC4 Gene

  • Protein details for NT5DC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-nucleotidase domain-containing protein 4
    Protein Accession:

    Protein attributes for NT5DC4 Gene

    428 amino acids
    Molecular mass:
    48951 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH41437.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NT5DC4 Gene

Proteomics data for NT5DC4 Gene at MOPED

Selected DME Specific Peptides for NT5DC4 Gene

Post-translational modifications for NT5DC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NT5DC4 Gene

ENSEMBL proteins:

Domains & Families for NT5DC4 Gene

Protein Domains for NT5DC4 Gene

Suggested Antigen Peptide Sequences for NT5DC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 5(3)-deoxyribonucleotidase family.
  • Belongs to the 5(3)-deoxyribonucleotidase family.
genes like me logo Genes that share domains with NT5DC4: view

No data available for Gene Families for NT5DC4 Gene

Function for NT5DC4 Gene

Enzyme Numbers (IUBMB) for NT5DC4 Gene

Gene Ontology (GO) - Molecular Function for NT5DC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008253 5-nucleotidase activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NT5DC4: view

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NT5DC4 Gene

Localization for NT5DC4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NT5DC4 Gene

Pathways & Interactions for NT5DC4 Gene

SuperPathways for NT5DC4 Gene

No Data Available

Interacting Proteins for NT5DC4 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000330247 for NT5DC4 Gene via STRING

Gene Ontology (GO) - Biological Process for NT5DC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation --
GO:0016311 dephosphorylation IBA --
genes like me logo Genes that share ontologies with NT5DC4: view

No data available for Pathways by source and SIGNOR curated interactions for NT5DC4 Gene

Drugs & Compounds for NT5DC4 Gene

No Compound Related Data Available

Transcripts for NT5DC4 Gene

mRNA/cDNA for NT5DC4 Gene

(10) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NT5DC4 Gene

5-nucleotidase domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NT5DC4 Gene

No ASD Table

Relevant External Links for NT5DC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5DC4 Gene

mRNA expression in normal human tissues for NT5DC4 Gene

mRNA differential expression in normal tissues according to GTEx for NT5DC4 Gene

This gene is overexpressed in Testis (x22.3), Whole Blood (x15.3), and Spleen (x5.1).

Protein differential expression in normal tissues from HIPED for NT5DC4 Gene

This gene is overexpressed in Salivary gland (43.0) and Testis (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NT5DC4 Gene

SOURCE GeneReport for Unigene cluster for NT5DC4 Gene Hs.589714

genes like me logo Genes that share expression patterns with NT5DC4: view

Protein tissue co-expression partners for NT5DC4 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NT5DC4 Gene

Orthologs for NT5DC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NT5DC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NT5DC4 36
  • 66 (a)
(Monodelphis domestica)
Mammalia NT5DC4 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 65 (a)
-- 36
  • 74 (a)
(Pan troglodytes)
Mammalia NT5DC4 36
  • 97 (a)
(Gallus gallus)
Aves -- 36
  • 72 (a)
-- 36
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 22 (a)
(Danio rerio)
Actinopterygii nt5c2l1 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32549 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea Y71H10B.1 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9662 36
  • 39 (a)
Species with no ortholog for NT5DC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NT5DC4 Gene

Gene Tree for NT5DC4 (if available)
Gene Tree for NT5DC4 (if available)

Paralogs for NT5DC4 Gene

Paralogs for NT5DC4 Gene

(1) SIMAP similar genes for NT5DC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NT5DC4: view

Variants for NT5DC4 Gene

Sequence variations from dbSNP and Humsavar for NT5DC4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs884659 -- 112,728,123(+) ATAAC(A/T)GTCTG intron-variant
rs908549 -- 112,727,906(+) GACCT(C/T)TACAC intron-variant
rs908550 -- 112,727,928(+) TCGAC(C/T)TCCTG intron-variant
rs908551 -- 112,728,502(+) CTGCA(C/T)GTGTC intron-variant
rs2063918 -- 112,721,312(+) CTGTA(A/G)CAACC upstream-variant-2KB, intron-variant

Variation tolerance for NT5DC4 Gene

Gene Damage Index Score: 5.51; 71.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NT5DC4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NT5DC4 Gene

Disorders for NT5DC4 Gene

Relevant External Links for NT5DC4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NT5DC4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5DC4 Gene

Publications for NT5DC4 Gene

  1. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 67
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for NT5DC4 Gene

Sources for NT5DC4 Gene

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