NT5DC4 Gene
protein-coding GIFtS: 35
GCID: GC02P113465 (predicted)
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5'-nucleotidase domain containing 4
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Aliases
for NT5DC4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 5'-Nucleotidase Domain Containing 41 2 | | EC 3.1.3.58 |
Export aliases for NT5DC4 gene to outside databasesPrevious GC identifers: GC02U900803 GC02P113196 GC02P105933 |
Summaries
for NT5DC4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for NT5DC4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NT_022135.16 NC_018913.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NT5DC4 gene promoter:
SRF SRF (504 AA) POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 HEN1 AREB6 FOXC1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for NT5DC4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NT5DC4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q13NT5DC4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P113465: view genomic region
(about GC identifiers)
Start:
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113,478,657 bp from pter |
End:
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113,500,456 bp from pter |
Size:
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21,800 bases |
Orientation:
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plus strand |
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Proteins
for NT5DC4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NT5D4_HUMAN, Q86YG4 (See
protein sequence)Recommended Name: 5'-nucleotidase domain-containing protein 4 Size: 428 amino acids; 48951 Da
Sequence caution: Sequence=AAH41437.1; Type=Erroneous initiation;Explore the universe of human proteins at neXtProt for NT5DC4: NX_Q86YG4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86YG4
2 DME Specific Peptides for NT5DC4 (Q86YG4)
NT5DC4 Protein expression data from MOPED and PaxDb: About this image 
ENSEMBL proteins: ENSP00000330247
Human Recombinant Protein Products:
NT5DC4 Antibody Products:
Assay Products for NT5DC4: |
Protein
Domains /
Families
for NT5DC4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NT5DC4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86YG4ProtoNet protein and cluster: Q86YG4 UniProtKB/Swiss-Prot: NT5D4_HUMAN, Q86YG4Similarity: Belongs to the 5'(3')-deoxyribonucleotidase family |
Function
for NT5DC4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 3.1.3.52
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5DC4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
NT5DC4 for ontologies About GeneDecksing
|
Pathways & Interactions
for NT5DC4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NT5DC4
|
Drugs & Compounds
for NT5DC4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NT5DC4
Search CenterWatch for drugs/clinical trials and news about NT5DC4 / NT5D4 
|
Transcripts
for NT5DC4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
Unigene Cluster for NT5DC4: 5'-nucleotidase domain containing 4 Hs.589714 [show with all ESTs]Unigene Representative Sequence: AK0927806 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000327581(uc002tid.3) ENST00000484666 ENST00000470675 ENST00000497526
ENST00000462854 ENST00000491170
Additional cDNA sequence: AK092780.1 BC041437.1 3 DOTS entries: DT.40265910 DT.95125814 DT.120991190
GeneLoc Exon Structure
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Expression
for NT5DC4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NT5DC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTTAAAAC
About this image
See NT5DC4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NT5DC4
SOURCE GeneReport for Unigene cluster: Hs.589714
SABiosciences Custom PCR Arrays for NT5DC4
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat NT5DC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NT5DC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NT5DC4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5DC4 |
Orthologs
for NT5DC4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for NT5DC4 gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
nt5c2l16 |
5'-nucleotidase, cytosolic II, like 1 |
48(a) |
1 ↔ 1 |
10(17490578-17514982) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG325496 |
-- |
29(a) |
1 → many |
X(18284521-18304168) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y71H10B.16 |
Protein Y71H10B.1, isoform c |
30(a) |
1 → many |
X(2834211-2840286) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G489606 |
HAD-superfamily hydrolase, subfamily IG, 5'-nucleo... |
20(a) |
possible ortholog |
5(19849543-19853564) |
rice
(Oryza sativa) |
Liliopsida |
-- |
5-nucleotidase domain-containing protein, putative... |
19(a) |
possible ortholog |
1(8274474-8282966) |
ENSEMBL Gene Tree for NT5DC4 (if available)
TreeFam Gene Tree for NT5DC4 (if available) |
Paralogs
for NT5DC4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NT5DC4 gene
- NT5DC32 NT5DC12 NT5C22 NT5DC22
1 SIMAP similar gene for NT5DC4 using alignment to 1 protein entry: NT5D4_HUMAN:NT5C2
NT5DC4 for paralogs About GeneDecksing
|
Genomic Variants
for NT5DC4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NT5DC4 (113478657 - 113500456 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NT5DC4: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for NT5DC4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for NT5DC4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NT5DC4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with NT5DC4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for NT5DC4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing NT5DC4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NT5DC4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NT5DC4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NT5DC4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NT5DC4 gene:
Search GeneIP for patents involving NT5DC4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NT5DC4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NT5DC4 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NT5DC4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NT5DC4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NT5DC4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NT5DC4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NT5DC4 |
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 |  |  |  | |
| | | | Search Tocris compounds for NT5DC4 |
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 | | | NT5DC4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5DC4 |
|  |  |  | | | | Search ThermoFisher Antibodies for NT5DC4 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat NT5DC4 |
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