Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NT5DC4 Gene

Aliases for NT5DC4 Gene

  • 5'-Nucleotidase Domain Containing 4 2
  • 5-Nucleotidase Domain Containing 4 2 3 5
  • EC 61

External Ids for NT5DC4 Gene

Previous GeneCards Identifiers for NT5DC4 Gene

  • GC02U900803
  • GC02P113196
  • GC02P113465
  • GC02P105933
  • GC02P112721
  • GC02P112722
  • GC02P112869

Summaries for NT5DC4 Gene

GeneCards Summary for NT5DC4 Gene

NT5DC4 (5'-Nucleotidase Domain Containing 4) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and 5-nucleotidase activity. An important paralog of this gene is NT5C2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5DC4 Gene

Genomics for NT5DC4 Gene

Regulatory Elements for NT5DC4 Gene

Enhancers for NT5DC4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G112621 2 FANTOM5 Ensembl ENCODE dbSUPER 12.2 -93.5 -93466 11.8 HDGF PKNOX1 FOXA2 ARNT CREB3L1 ARID4B SIN3A FEZF1 ZNF2 YY1 FLJ42351 POLR1B CHCHD5 NT5DC4 ENSG00000243389 ENSG00000207383 IL37 IL1B ANAPC1 IL1A
GH02G112699 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -20.2 -20199 2.6 PKNOX1 MAX BMI1 CEBPG RELA ARID3A NFE2 RELB IKZF2 SMARCE1 IL1RN NT5DC4 FLJ42351 SLC20A1 IL36B ENSG00000243389 CHCHD5 ENSG00000207383 IL1B IL1A
GH02G112682 1.5 Ensembl ENCODE dbSUPER 13 -36.8 -36781 3.6 ATF1 CREB3L1 ARNT E2F7 TCF12 ZNF121 ZNF766 ELK1 GATA2 NCOA1 FLJ42351 NT5DC4 SLC20A1 ENSG00000243389 ENSG00000207383 CHCHD5 IL37 RGPD8 LOC102724955
GH02G112724 1.3 Ensembl ENCODE 6.9 +5.3 5327 2.7 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF2 ZNF143 SP3 SP5 FLJ42351 SLC20A1 ENSG00000243389 CHCHD5 ENSG00000207383 IL1B CKAP2L IL37 NT5DC4 RGPD8
GH02G112614 0.7 Ensembl ENCODE 12.1 -106.2 -106233 0.8 HMG20A RBBP5 NR2F6 FLJ42351 SLC20A1 ENSG00000243389 ENSG00000207383 CHCHD5 NT5DC4 IL37 RPS20P11 GC02P113173
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NT5DC4 on UCSC Golden Path with GeneCards custom track

Genomic Location for NT5DC4 Gene

112,720,810 bp from pter
112,742,879 bp from pter
22,070 bases
Plus strand

Genomic View for NT5DC4 Gene

Genes around NT5DC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5DC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5DC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5DC4 Gene

Proteins for NT5DC4 Gene

  • Protein details for NT5DC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-nucleotidase domain-containing protein 4
    Protein Accession:

    Protein attributes for NT5DC4 Gene

    428 amino acids
    Molecular mass:
    48951 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH41437.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NT5DC4 Gene

Selected DME Specific Peptides for NT5DC4 Gene


Post-translational modifications for NT5DC4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NT5DC4 Gene

Protein Domains for NT5DC4 Gene

Suggested Antigen Peptide Sequences for NT5DC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 5(3)-deoxyribonucleotidase family.
  • Belongs to the 5(3)-deoxyribonucleotidase family.
genes like me logo Genes that share domains with NT5DC4: view

No data available for Gene Families for NT5DC4 Gene

Function for NT5DC4 Gene

Enzyme Numbers (IUBMB) for NT5DC4 Gene

Gene Ontology (GO) - Molecular Function for NT5DC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008253 5-nucleotidase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NT5DC4: view

Animal Model Products

No data available for Molecular function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NT5DC4 Gene

Localization for NT5DC4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NT5DC4 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
lysosome 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NT5DC4 Gene

Pathways & Interactions for NT5DC4 Gene

SuperPathways for NT5DC4 Gene

No Data Available

Interacting Proteins for NT5DC4 Gene

Gene Ontology (GO) - Biological Process for NT5DC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NT5DC4: view

No data available for Pathways by source and SIGNOR curated interactions for NT5DC4 Gene

Drugs & Compounds for NT5DC4 Gene

No Compound Related Data Available

Transcripts for NT5DC4 Gene

mRNA/cDNA for NT5DC4 Gene

(15) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NT5DC4 Gene

5-nucleotidase domain containing 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NT5DC4 Gene

No ASD Table

Relevant External Links for NT5DC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5DC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NT5DC4 Gene

mRNA differential expression in normal tissues according to GTEx for NT5DC4 Gene

This gene is overexpressed in Testis (x22.3), Whole Blood (x15.3), and Spleen (x5.1).

Protein differential expression in normal tissues from HIPED for NT5DC4 Gene

This gene is overexpressed in Salivary gland (43.0) and Testis (26.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NT5DC4 Gene

Protein tissue co-expression partners for NT5DC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of NT5DC4 Gene:


SOURCE GeneReport for Unigene cluster for NT5DC4 Gene:


Evidence on tissue expression from TISSUES for NT5DC4 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with NT5DC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NT5DC4 Gene

Orthologs for NT5DC4 Gene

This gene was present in the common ancestor of animals.

Orthologs for NT5DC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NT5DC4 35
  • 97 (a)
(Monodelphis domestica)
Mammalia NT5DC4 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
-- 35
  • 65 (a)
(Bos Taurus)
Mammalia NT5DC4 35
  • 66 (a)
(Gallus gallus)
Aves -- 35
  • 72 (a)
-- 35
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 22 (a)
(Danio rerio)
Actinopterygii nt5c2l1 35
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32549 35
  • 30 (a)
(Caenorhabditis elegans)
Secernentea Y71H10B.1 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9662 35
  • 39 (a)
Species where no ortholog for NT5DC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NT5DC4 Gene

Gene Tree for NT5DC4 (if available)
Gene Tree for NT5DC4 (if available)

Paralogs for NT5DC4 Gene

Paralogs for NT5DC4 Gene

(1) SIMAP similar genes for NT5DC4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NT5DC4: view

Variants for NT5DC4 Gene

Sequence variations from dbSNP and Humsavar for NT5DC4 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000099265 -- 112,729,739(+) GCTTG(A/G)GGTCC intron-variant
rs1000155036 -- 112,726,133(+) CAGCT(C/T)AGGGT intron-variant
rs1000165157 -- 112,728,542(+) ATTTG(A/G)TAAGA intron-variant
rs1000209677 -- 112,730,513(+) ACATT(A/G)ATGAC intron-variant
rs1000240737 -- 112,730,205(+) CTACC(C/T)GGGAG intron-variant

Variation tolerance for NT5DC4 Gene

Gene Damage Index Score: 5.51; 71.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NT5DC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NT5DC4 Gene

Disorders for NT5DC4 Gene

Relevant External Links for NT5DC4

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NT5DC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5DC4 Gene

Publications for NT5DC4 Gene

  1. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for NT5DC4 Gene

Sources for NT5DC4 Gene

Loading form....