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Aliases for NT5DC3 Gene

Aliases for NT5DC3 Gene

  • 5'-Nucleotidase Domain Containing 3 2
  • 5-Nucleotidase Domain Containing 3 2 3 5
  • TU12B1-TY 3 4
  • 5-Nucleotidase Domain-Containing Protein 3 3
  • GRP94-Neighboring Nucleotidase 4
  • EC 3.1.3.- 4
  • TU12B1TY 3
  • GNN 4

External Ids for NT5DC3 Gene

Previous GeneCards Identifiers for NT5DC3 Gene

  • GC12M102669
  • GC12M104164
  • GC12M101226

Summaries for NT5DC3 Gene

GeneCards Summary for NT5DC3 Gene

NT5DC3 (5'-Nucleotidase Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and 5-nucleotidase activity. An important paralog of this gene is NT5DC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5DC3 Gene

Genomics for NT5DC3 Gene

Regulatory Elements for NT5DC3 Gene

Enhancers for NT5DC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F103797 1.7 FANTOM5 Ensembl ENCODE 35.1 +38.3 38329 11.0 ATF1 ARNT SIN3A ZNF2 GTF3C2 ZNF121 ZNF766 GATA2 ZNF143 FOS NT5DC3 ENSG00000257681 RPL18AP3 ENSG00000257754
GH12F103831 1.1 FANTOM5 Ensembl ENCODE 36 +8.2 8247 2.8 OSR2 CTCF MTA2 IKZF1 RAD21 SPI1 NT5DC3 ENSG00000257681 TDG ENSG00000257754
GH12F103808 0.8 ENCODE 35.4 +31.7 31736 1.2 HDAC1 LEF1 PKNOX1 CBX3 TAL1 ZFP64 ZIC2 GATA2 NCOR1 SCRT2 NT5DC3 ENSG00000257681 ENSG00000257754
GH12F103827 0.8 Ensembl ENCODE 32.3 +12.7 12664 2.0 OSR2 SCRT1 RNF2 SCRT2 KLF9 BMI1 EGR2 NT5DC3 ENSG00000257681 TDG ENSG00000257754
GH12F103900 0.9 Ensembl ENCODE 15.8 -61.0 -60983 3.1 CHD1 SIN3A REST DPF2 CHD7 ZNF664 GATA3 CTBP1 POLR2A ZBTB33 TTC41P NT5DC3 MIR3652 HSP90B1 C12orf73 ENSG00000257327
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NT5DC3 on UCSC Golden Path with GeneCards custom track

Promoters for NT5DC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000654264 445 2801 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 FOS SP3

Genomic Location for NT5DC3 Gene

Chromosome:
12
Start:
103,763,312 bp from pter
End:
103,841,245 bp from pter
Size:
77,934 bases
Orientation:
Minus strand

Genomic View for NT5DC3 Gene

Genes around NT5DC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5DC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5DC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5DC3 Gene

Proteins for NT5DC3 Gene

  • Protein details for NT5DC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UY8-NT5D3_HUMAN
    Recommended name:
    5-nucleotidase domain-containing protein 3
    Protein Accession:
    Q86UY8
    Secondary Accessions:
    • Q9NUM7
    • Q9P2T2
    • Q9P2T3

    Protein attributes for NT5DC3 Gene

    Size:
    548 amino acids
    Molecular mass:
    63420 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92095.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA93053.1; Type=Frameshift; Positions=62; Evidence={ECO:0000305};

    Alternative splice isoforms for NT5DC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NT5DC3 Gene

Post-translational modifications for NT5DC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NT5DC3 Gene

No data available for DME Specific Peptides for NT5DC3 Gene

Domains & Families for NT5DC3 Gene

Protein Domains for NT5DC3 Gene

Suggested Antigen Peptide Sequences for NT5DC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UY8

UniProtKB/Swiss-Prot:

NT5D3_HUMAN :
  • Belongs to the 5(3)-deoxyribonucleotidase family.
Family:
  • Belongs to the 5(3)-deoxyribonucleotidase family.
genes like me logo Genes that share domains with NT5DC3: view

No data available for Gene Families for NT5DC3 Gene

Function for NT5DC3 Gene

Enzyme Numbers (IUBMB) for NT5DC3 Gene

Gene Ontology (GO) - Molecular Function for NT5DC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008253 5-nucleotidase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NT5DC3: view

Phenotypes for NT5DC3 Gene

GenomeRNAi human phenotypes for NT5DC3:
genes like me logo Genes that share phenotypes with NT5DC3: view

Animal Model Products

miRNA for NT5DC3 Gene

miRTarBase miRNAs that target NT5DC3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5DC3 Gene

Localization for NT5DC3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NT5DC3 gene
Compartment Confidence
mitochondrion 4
cytosol 3

Gene Ontology (GO) - Cellular Components for NT5DC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with NT5DC3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NT5DC3 Gene

Pathways & Interactions for NT5DC3 Gene

SuperPathways for NT5DC3 Gene

No Data Available

Interacting Proteins for NT5DC3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376615%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000306906%0d%0a9606.ENSP00000430237%0d%0a
Selected Interacting proteins: ENSP00000376615 Q86UY8-NT5D3_HUMAN for NT5DC3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NT5DC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NT5DC3: view

No data available for Pathways by source and SIGNOR curated interactions for NT5DC3 Gene

Drugs & Compounds for NT5DC3 Gene

(1) Drugs for NT5DC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with NT5DC3: view

Transcripts for NT5DC3 Gene

Unigene Clusters for NT5DC3 Gene

5-nucleotidase domain containing 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NT5DC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: - - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for NT5DC3 Gene

GeneLoc Exon Structure for
NT5DC3
ECgene alternative splicing isoforms for
NT5DC3

Expression for NT5DC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NT5DC3 Gene

mRNA differential expression in normal tissues according to GTEx for NT5DC3 Gene

This gene is overexpressed in Colon - Sigmoid (x11.3) and Esophagus - Muscularis (x4.7).

Protein differential expression in normal tissues from HIPED for NT5DC3 Gene

This gene is overexpressed in Frontal cortex (14.9), Colon (9.1), Rectum (7.7), Uterus (6.8), and Urinary Bladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NT5DC3 Gene



NURSA nuclear receptor signaling pathways regulating expression of NT5DC3 Gene:

NT5DC3

SOURCE GeneReport for Unigene cluster for NT5DC3 Gene:

Hs.48428

mRNA Expression by UniProt/SwissProt for NT5DC3 Gene:

Q86UY8-NT5D3_HUMAN
Tissue specificity: Expressed in brain, placenta, skeletal muscle, pancreas, testis, uterus, and small intestine. Reduced expression in pancreatic cancer cells.
genes like me logo Genes that share expression patterns with NT5DC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for NT5DC3 Gene

Orthologs for NT5DC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NT5DC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NT5DC3 34 35
  • 99.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NT5DC3 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NT5DC3 34 35
  • 89.82 (n)
dog
(Canis familiaris)
Mammalia NT5DC3 34 35
  • 89.48 (n)
oppossum
(Monodelphis domestica)
Mammalia NT5DC3 35
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nt5dc3 34
  • 86.76 (n)
mouse
(Mus musculus)
Mammalia Nt5dc3 34 16 35
  • 86.69 (n)
chicken
(Gallus gallus)
Aves NT5DC3 34 35
  • 80.81 (n)
lizard
(Anolis carolinensis)
Reptilia NT5DC3 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5dc3 34
  • 73.43 (n)
zebrafish
(Danio rerio)
Actinopterygii nt5dc3 34 35
  • 71.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1814 34 35
  • 53.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
OneToMany
Species where no ortholog for NT5DC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5DC3 Gene

ENSEMBL:
Gene Tree for NT5DC3 (if available)
TreeFam:
Gene Tree for NT5DC3 (if available)

Paralogs for NT5DC3 Gene

Paralogs for NT5DC3 Gene

(2) SIMAP similar genes for NT5DC3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NT5DC3: view

Variants for NT5DC3 Gene

Sequence variations from dbSNP and Humsavar for NT5DC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10082821 -- 103,798,728(+) CAATG(A/G)TTTTC intron-variant
rs10431459 -- 103,750,091(+) gtggg(G/T)attaa intron-variant
rs1043469 -- 103,772,982(-) AATAT(A/C)CCTCT intron-variant, utr-variant-3-prime
rs10552367 -- 103,840,378(+) CACAG(-/CTCAT)CTCAT intron-variant, upstream-variant-2KB
rs1056297 -- 103,760,017(-) TATCC(A/C)CCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NT5DC3 Gene

Variant ID Type Subtype PubMed ID
esv34031 CNV loss 18971310
esv3892262 CNV gain 25118596
nsv1126318 CNV deletion 24896259
nsv52873 CNV deletion 16902084
nsv560039 CNV gain 21841781

Variation tolerance for NT5DC3 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NT5DC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NT5DC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5DC3 Gene

Disorders for NT5DC3 Gene

Relevant External Links for NT5DC3

Genetic Association Database (GAD)
NT5DC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NT5DC3

No disorders were found for NT5DC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5DC3 Gene

Publications for NT5DC3 Gene

  1. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PMID: 18839057) Lesch K.P. … Jacob C. (J Neural Transm 2008) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. TU12B1-TY, a novel gene in the region at 12q22-q23.1 frequently deleted in pancreatic cancer, shows reduced expression in pancreatic cancer cells. (PMID: 15547748) Yatsuoka T. … Horii A. (Oncol. Rep. 2004) 3 4 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for NT5DC3 Gene

Sources for NT5DC3 Gene

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