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Aliases for NT5DC3 Gene

Aliases for NT5DC3 Gene

  • 5'-Nucleotidase Domain Containing 3 2
  • 5-Nucleotidase Domain Containing 3 2 3 5
  • TU12B1-TY 3 4
  • GRP94-Neighboring Nucleotidase 4
  • EC 3.1.3.- 4
  • TU12B1TY 3
  • GNN 4

External Ids for NT5DC3 Gene

Previous GeneCards Identifiers for NT5DC3 Gene

  • GC12M102669
  • GC12M104164
  • GC12M101226

Summaries for NT5DC3 Gene

GeneCards Summary for NT5DC3 Gene

NT5DC3 (5'-Nucleotidase Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and 5-nucleotidase activity. An important paralog of this gene is NT5DC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5DC3 Gene

Genomics for NT5DC3 Gene

Regulatory Elements for NT5DC3 Gene

Enhancers for NT5DC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NT5DC3 on UCSC Golden Path with GeneCards custom track

Promoters for NT5DC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NT5DC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NT5DC3 Gene

103,763,312 bp from pter
103,841,245 bp from pter
77,934 bases
Minus strand

Genomic View for NT5DC3 Gene

Genes around NT5DC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5DC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5DC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5DC3 Gene

Proteins for NT5DC3 Gene

  • Protein details for NT5DC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-nucleotidase domain-containing protein 3
    Protein Accession:
    Secondary Accessions:
    • Q9NUM7
    • Q9P2T2
    • Q9P2T3

    Protein attributes for NT5DC3 Gene

    548 amino acids
    Molecular mass:
    63420 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=BAA92095.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA93053.1; Type=Frameshift; Positions=62; Evidence={ECO:0000305};

    Alternative splice isoforms for NT5DC3 Gene


neXtProt entry for NT5DC3 Gene

Proteomics data for NT5DC3 Gene at MOPED

Post-translational modifications for NT5DC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NT5DC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NT5DC3 Gene

Domains & Families for NT5DC3 Gene

Protein Domains for NT5DC3 Gene

Suggested Antigen Peptide Sequences for NT5DC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 5(3)-deoxyribonucleotidase family.
  • Belongs to the 5(3)-deoxyribonucleotidase family.
genes like me logo Genes that share domains with NT5DC3: view

No data available for Gene Families for NT5DC3 Gene

Function for NT5DC3 Gene

Enzyme Numbers (IUBMB) for NT5DC3 Gene

Gene Ontology (GO) - Molecular Function for NT5DC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008253 5-nucleotidase activity IBA --
genes like me logo Genes that share ontologies with NT5DC3: view

Phenotypes for NT5DC3 Gene

GenomeRNAi human phenotypes for NT5DC3:
genes like me logo Genes that share phenotypes with NT5DC3: view

Animal Model Products

miRNA for NT5DC3 Gene

miRTarBase miRNAs that target NT5DC3

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5DC3 Gene

Localization for NT5DC3 Gene

Subcellular locations from

Jensen Localization Image for NT5DC3 Gene COMPARTMENTS Subcellular localization image for NT5DC3 gene
Compartment Confidence
mitochondrion 4
cytosol 3

Gene Ontology (GO) - Cellular Components for NT5DC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with NT5DC3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NT5DC3 Gene

Pathways & Interactions for NT5DC3 Gene

SuperPathways for NT5DC3 Gene

No Data Available

Interacting Proteins for NT5DC3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000376615 Q86UY8-NT5D3_HUMAN for NT5DC3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for NT5DC3 Gene


No data available for Pathways by source and SIGNOR curated interactions for NT5DC3 Gene

Drugs & Compounds for NT5DC3 Gene

(1) Drugs for NT5DC3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0
genes like me logo Genes that share compounds with NT5DC3: view

Transcripts for NT5DC3 Gene

Unigene Clusters for NT5DC3 Gene

5-nucleotidase domain containing 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NT5DC3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18 ^ 19
SP1: - - -
SP3: -

Relevant External Links for NT5DC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5DC3 Gene

mRNA expression in normal human tissues for NT5DC3 Gene

mRNA differential expression in normal tissues according to GTEx for NT5DC3 Gene

This gene is overexpressed in Colon - Sigmoid (x11.3) and Esophagus - Muscularis (x4.7).

Protein differential expression in normal tissues from HIPED for NT5DC3 Gene

This gene is overexpressed in Frontal cortex (14.9), Colon (9.1), Rectum (7.7), Uterus (6.8), and Urinary Bladder (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NT5DC3 Gene

SOURCE GeneReport for Unigene cluster for NT5DC3 Gene Hs.48428

mRNA Expression by UniProt/SwissProt for NT5DC3 Gene

Tissue specificity: Expressed in brain, placenta, skeletal muscle, pancreas, testis, uterus, and small intestine. Reduced expression in pancreatic cancer cells.
genes like me logo Genes that share expression patterns with NT5DC3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for NT5DC3 Gene

Orthologs for NT5DC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for NT5DC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NT5DC3 35
  • 89.82 (n)
  • 95.45 (a)
NT5DC3 36
  • 94 (a)
(Canis familiaris)
Mammalia NT5DC3 35
  • 89.48 (n)
  • 96.54 (a)
NT5DC3 36
  • 91 (a)
(Mus musculus)
Mammalia Nt5dc3 35
  • 86.69 (n)
  • 92.97 (a)
Nt5dc3 16
Nt5dc3 36
  • 92 (a)
(Pan troglodytes)
Mammalia NT5DC3 35
  • 99.64 (n)
  • 100 (a)
NT5DC3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nt5dc3 35
  • 86.76 (n)
  • 93.92 (a)
(Monodelphis domestica)
Mammalia NT5DC3 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia NT5DC3 36
  • 94 (a)
(Gallus gallus)
Aves NT5DC3 35
  • 80.81 (n)
  • 88.48 (a)
NT5DC3 36
  • 85 (a)
(Anolis carolinensis)
Reptilia NT5DC3 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5dc3 35
  • 73.43 (n)
  • 79.92 (a)
(Danio rerio)
Actinopterygii nt5dc3 35
  • 71.91 (n)
  • 77.09 (a)
nt5dc3 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1814 35
  • 53.29 (n)
  • 48.02 (a)
CG1814 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for NT5DC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5DC3 Gene

Gene Tree for NT5DC3 (if available)
Gene Tree for NT5DC3 (if available)

Paralogs for NT5DC3 Gene

Paralogs for NT5DC3 Gene

(2) SIMAP similar genes for NT5DC3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NT5DC3: view

Variants for NT5DC3 Gene

Sequence variations from dbSNP and Humsavar for NT5DC3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs12184494 - 103,793,954(+) CAATT(G/T)CTCTG intron-variant, nc-transcript-variant, reference, missense
rs1968513 -- 103,786,973(+) CCACC(A/G)TGCCC intron-variant, downstream-variant-500B
rs2033774 -- 103,827,137(+) CTACT(A/C/T)GGGAA intron-variant
rs9084 -- 103,773,604(-) AGAAC(C/T)TACAT intron-variant, utr-variant-3-prime
rs9132 -- 103,772,465(-) ATCTC(A/G)TGGAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NT5DC3 Gene

Variant ID Type Subtype PubMed ID
dgv1486n71 CNV Gain 21882294
esv34031 CNV Loss 18971310
nsv899486 CNV Gain 21882294
dgv1488n71 CNV Gain 21882294
dgv1489n71 CNV Gain 21882294
nsv52873 CNV Loss 16902084

Variation tolerance for NT5DC3 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.20% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NT5DC3 Gene

Disorders for NT5DC3 Gene

Relevant External Links for NT5DC3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NT5DC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5DC3 Gene

Publications for NT5DC3 Gene

  1. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PMID: 18839057) Lesch K.P. … Jacob C. (J Neural Transm 2008) 3 48 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. (PMID: 23382219) Ghai R. … Collins B.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  4. A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention. (PMID: 21878436) Sampietro M.L. … Jukema J.W. (Hum. Mol. Genet. 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for NT5DC3 Gene

Sources for NT5DC3 Gene