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Aliases for NT5DC2 Gene

Aliases for NT5DC2 Gene

  • 5'-Nucleotidase Domain Containing 2 2
  • 5-Nucleotidase Domain Containing 2 2 3 5
  • EC 3.1.3.- 4

External Ids for NT5DC2 Gene

Summaries for NT5DC2 Gene

GeneCards Summary for NT5DC2 Gene

NT5DC2 (5'-Nucleotidase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and 5-nucleotidase activity. An important paralog of this gene is NT5DC3.

Additional gene information for NT5DC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5DC2 Gene

Genomics for NT5DC2 Gene

Regulatory Elements for NT5DC2 Gene

Enhancers for NT5DC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H052528 1.6 Ensembl ENCODE dbSUPER 24.7 +1.4 1425 9 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 NT5DC2 PBRM1 STAB1 ITIH4 ITIH1 GNL3 NEK4 RPL29 SMIM4 PIR41495
GH03H052044 2 FANTOM5 Ensembl ENCODE dbSUPER 13.6 +483.5 483455 13 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF416 ZNF143 ZNF207 DCAF1 GPR62 RAD54L2 PHF7 NT5DC2 RPL29 DUSP7 PCBP4 WDR82 SFMBT1
GH03H052466 1.1 VISTA FANTOM5 dbSUPER 22.1 +66.9 66897 3 ZNF121 POLR2A MNT PRDM1 NR2F2 NT5DC2 SEMA3G STAB1 SMIM4 RNU6-856P RNU6ATAC16P PBRM1 GNL3 ENSG00000222345 ENSG00000252787
GH03H052489 1 Ensembl ENCODE dbSUPER 21.6 +44.2 44223 2 TBP JUN MAX MYC NR2F2 NT5DC2 SMIM4 STAB1 PIR37247
GH03H052668 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -135.6 -135581 3 HDGF BMI1 BATF FOS ATF7 RUNX3 CREM IKZF2 CBFB CEBPB PBRM1 SNORD69 NT5DC2 ITIH4 ITIH1 GLYCTK PRKCD TMEM110 WDR82 GNL3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NT5DC2 on UCSC Golden Path with GeneCards custom track

Promoters for NT5DC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152571 1377 1401 TBP ATF1 RB1 ARNT ARID4B DMAP1 FOS SMARCA5 KLF11 SP3
ENSR00000152572 -1923 1601 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for NT5DC2 Gene

Chromosome:
3
Start:
52,524,369 bp from pter
End:
52,535,077 bp from pter
Size:
10,709 bases
Orientation:
Minus strand

Genomic View for NT5DC2 Gene

Genes around NT5DC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5DC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5DC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5DC2 Gene

Proteins for NT5DC2 Gene

  • Protein details for NT5DC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H857-NT5D2_HUMAN
    Recommended name:
    5-nucleotidase domain-containing protein 2
    Protein Accession:
    Q9H857
    Secondary Accessions:
    • C9JTZ6
    • E9PAL9
    • O95888
    • Q96C80
    • Q9H9Z8

    Protein attributes for NT5DC2 Gene

    Size:
    520 amino acids
    Molecular mass:
    60719 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14550.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14064.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NT5DC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NT5DC2 Gene

Post-translational modifications for NT5DC2 Gene

  • Ubiquitination at posLast=102102
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NT5DC2 Gene

Domains & Families for NT5DC2 Gene

Gene Families for NT5DC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NT5DC2 Gene

Suggested Antigen Peptide Sequences for NT5DC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H857

UniProtKB/Swiss-Prot:

NT5D2_HUMAN :
  • Belongs to the 5(3)-deoxyribonucleotidase family.
Family:
  • Belongs to the 5(3)-deoxyribonucleotidase family.
genes like me logo Genes that share domains with NT5DC2: view

Function for NT5DC2 Gene

Enzyme Numbers (IUBMB) for NT5DC2 Gene

Phenotypes From GWAS Catalog for NT5DC2 Gene

Gene Ontology (GO) - Molecular Function for NT5DC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008253 5-nucleotidase activity IBA --
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NT5DC2: view
genes like me logo Genes that share phenotypes with NT5DC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NT5DC2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5DC2 Gene

Localization for NT5DC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NT5DC2 gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NT5DC2 Gene

Pathways & Interactions for NT5DC2 Gene

SuperPathways for NT5DC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NT5DC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NT5DC2: view

No data available for Pathways by source and SIGNOR curated interactions for NT5DC2 Gene

Drugs & Compounds for NT5DC2 Gene

No Compound Related Data Available

Transcripts for NT5DC2 Gene

Unigene Clusters for NT5DC2 Gene

5-nucleotidase domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NT5DC2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NT5DC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6:
SP7: -
SP8: -
SP9: - - - -
SP10: - - - - -
SP11: -
SP12:
SP13:
SP14:
SP15: -

ExUns: 19a · 19b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for NT5DC2 Gene

GeneLoc Exon Structure for
NT5DC2
ECgene alternative splicing isoforms for
NT5DC2

Expression for NT5DC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NT5DC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NT5DC2 Gene

This gene is overexpressed in Breast (20.7), Salivary gland (15.7), and Fetal heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NT5DC2 Gene



Protein tissue co-expression partners for NT5DC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NT5DC2 Gene:

NT5DC2

SOURCE GeneReport for Unigene cluster for NT5DC2 Gene:

Hs.84753

Evidence on tissue expression from TISSUES for NT5DC2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with NT5DC2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NT5DC2 Gene

Orthologs for NT5DC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NT5DC2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NT5DC2 33 34
  • 98.83 (n)
cow
(Bos Taurus)
Mammalia NT5DC2 33 34
  • 91.74 (n)
dog
(Canis familiaris)
Mammalia NT5DC2 33 34
  • 90.82 (n)
mouse
(Mus musculus)
Mammalia Nt5dc2 33 16 34
  • 90.09 (n)
rat
(Rattus norvegicus)
Mammalia Nt5dc2 33
  • 90.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NT5DC2 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NT5DC2 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves NT5DC2 33 34
  • 74.74 (n)
lizard
(Anolis carolinensis)
Reptilia NT5DC2 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5dc2 33
  • 69.9 (n)
Str.295 33
African clawed frog
(Xenopus laevis)
Amphibia MGC53840 33
zebrafish
(Danio rerio)
Actinopterygii nt5dc2 33 34
  • 69.95 (n)
wufb83e03 33
fruit fly
(Drosophila melanogaster)
Insecta CG1814 34
  • 40 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23890 33
  • 47.59 (n)
rice
(Oryza sativa)
Liliopsida Os09g0424600 33
  • 48.4 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToMany
Species where no ortholog for NT5DC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5DC2 Gene

ENSEMBL:
Gene Tree for NT5DC2 (if available)
TreeFam:
Gene Tree for NT5DC2 (if available)

Paralogs for NT5DC2 Gene

Paralogs for NT5DC2 Gene

(1) SIMAP similar genes for NT5DC2 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for NT5DC2 Gene

genes like me logo Genes that share paralogs with NT5DC2: view

Variants for NT5DC2 Gene

Sequence variations from dbSNP and Humsavar for NT5DC2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000039280 -- 52,536,808(+) GAAGC(A/G)GCGAT upstream-variant-2KB, reference, missense
rs1000449787 -- 52,531,698(+) GCTGA(A/G)GGTGT intron-variant
rs1000810387 -- 52,525,412(+) CCCAT(A/G)GCCTT intron-variant
rs1000859453 -- 52,527,112(+) GGCTG(C/T)TTGAC intron-variant
rs1001051732 -- 52,533,104(+) CCGCC(C/T)GGCGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for NT5DC2 Gene

Variant ID Type Subtype PubMed ID
dgv8326n54 CNV loss 21841781
esv27812 CNV loss 19812545
esv3596160 CNV gain 21293372
nsv1072693 CNV deletion 25765185
nsv3820 CNV insertion 18451855
nsv834697 CNV loss 17160897
nsv954862 CNV deletion 24416366

Variation tolerance for NT5DC2 Gene

Residual Variation Intolerance Score: 8.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.51; 85.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NT5DC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NT5DC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5DC2 Gene

Disorders for NT5DC2 Gene

Relevant External Links for NT5DC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NT5DC2

No disorders were found for NT5DC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5DC2 Gene

Publications for NT5DC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 2 3 60
  4. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B … Gibbs RA (Analytical biochemistry 1996) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for NT5DC2 Gene

Sources for NT5DC2 Gene

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