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Aliases for NT5DC2 Gene

Aliases for NT5DC2 Gene

  • 5'-Nucleotidase Domain Containing 2 2
  • 5-Nucleotidase Domain Containing 2 2 3 5
  • EC 3.1.3.- 4

External Ids for NT5DC2 Gene

Summaries for NT5DC2 Gene

GeneCards Summary for NT5DC2 Gene

NT5DC2 (5'-Nucleotidase Domain Containing 2) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and 5-nucleotidase activity. An important paralog of this gene is NT5DC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5DC2 Gene

Genomics for NT5DC2 Gene

Regulatory Elements for NT5DC2 Gene

Enhancers for NT5DC2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NT5DC2 on UCSC Golden Path with GeneCards custom track

Promoters for NT5DC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NT5DC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NT5DC2 Gene

52,524,369 bp from pter
52,535,077 bp from pter
10,709 bases
Minus strand

Genomic View for NT5DC2 Gene

Genes around NT5DC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5DC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5DC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5DC2 Gene

Proteins for NT5DC2 Gene

  • Protein details for NT5DC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5-nucleotidase domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • C9JTZ6
    • E9PAL9
    • O95888
    • Q96C80
    • Q9H9Z8

    Protein attributes for NT5DC2 Gene

    520 amino acids
    Molecular mass:
    60719 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH14550.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14064.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NT5DC2 Gene


neXtProt entry for NT5DC2 Gene

Proteomics data for NT5DC2 Gene at MOPED

Post-translational modifications for NT5DC2 Gene

  • Ubiquitination at Lys 102
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for NT5DC2 Gene

Domains & Families for NT5DC2 Gene

Protein Domains for NT5DC2 Gene

Suggested Antigen Peptide Sequences for NT5DC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 5(3)-deoxyribonucleotidase family.
  • Belongs to the 5(3)-deoxyribonucleotidase family.
genes like me logo Genes that share domains with NT5DC2: view

No data available for Gene Families for NT5DC2 Gene

Function for NT5DC2 Gene

Enzyme Numbers (IUBMB) for NT5DC2 Gene

Gene Ontology (GO) - Molecular Function for NT5DC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008253 5-nucleotidase activity IBA --
genes like me logo Genes that share ontologies with NT5DC2: view
genes like me logo Genes that share phenotypes with NT5DC2: view

Animal Model Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5DC2 Gene

Localization for NT5DC2 Gene

Subcellular locations from

Jensen Localization Image for NT5DC2 Gene COMPARTMENTS Subcellular localization image for NT5DC2 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NT5DC2 Gene

Pathways & Interactions for NT5DC2 Gene

SuperPathways for NT5DC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NT5DC2 Gene


No data available for Pathways by source and SIGNOR curated interactions for NT5DC2 Gene

Drugs & Compounds for NT5DC2 Gene

No Compound Related Data Available

Transcripts for NT5DC2 Gene

Unigene Clusters for NT5DC2 Gene

5-nucleotidase domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NT5DC2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP7: -
SP8: -
SP9: - - - -
SP10: - - - - -
SP11: -
SP15: -

ExUns: 19a · 19b

Relevant External Links for NT5DC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5DC2 Gene

mRNA expression in normal human tissues for NT5DC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NT5DC2 Gene

This gene is overexpressed in Breast (20.7), Salivary gland (15.7), and Fetal heart (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NT5DC2 Gene

SOURCE GeneReport for Unigene cluster for NT5DC2 Gene Hs.84753

genes like me logo Genes that share expression patterns with NT5DC2: view

Protein tissue co-expression partners for NT5DC2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NT5DC2 Gene

Orthologs for NT5DC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NT5DC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NT5DC2 35
  • 91.74 (n)
  • 95.78 (a)
NT5DC2 36
  • 96 (a)
(Canis familiaris)
Mammalia NT5DC2 35
  • 90.82 (n)
  • 96.75 (a)
NT5DC2 36
  • 93 (a)
(Mus musculus)
Mammalia Nt5dc2 35
  • 90.09 (n)
  • 97.95 (a)
Nt5dc2 16
Nt5dc2 36
  • 98 (a)
(Pan troglodytes)
Mammalia NT5DC2 35
  • 98.83 (n)
  • 98.55 (a)
NT5DC2 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Nt5dc2 35
  • 90.02 (n)
  • 97.04 (a)
(Monodelphis domestica)
Mammalia NT5DC2 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia NT5DC2 36
  • 79 (a)
(Gallus gallus)
Aves NT5DC2 35
  • 74.74 (n)
  • 79.11 (a)
NT5DC2 36
  • 76 (a)
(Anolis carolinensis)
Reptilia NT5DC2 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5dc2 35
  • 69.9 (n)
  • 73.59 (a)
Str.295 35
African clawed frog
(Xenopus laevis)
Amphibia MGC53840 35
(Danio rerio)
Actinopterygii nt5dc2 35
  • 69.95 (n)
  • 72.24 (a)
wufb83e03 35
nt5dc2 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1814 36
  • 40 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G23890 35
  • 47.59 (n)
  • 40.42 (a)
(Oryza sativa)
Liliopsida Os09g0424600 35
  • 48.4 (n)
  • 40.28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
Species with no ortholog for NT5DC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5DC2 Gene

Gene Tree for NT5DC2 (if available)
Gene Tree for NT5DC2 (if available)

Paralogs for NT5DC2 Gene

Paralogs for NT5DC2 Gene

(1) SIMAP similar genes for NT5DC2 Gene using alignment to 5 proteins: Pseudogenes for NT5DC2 Gene

genes like me logo Genes that share paralogs with NT5DC2: view

Variants for NT5DC2 Gene

Sequence variations from dbSNP and Humsavar for NT5DC2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs35920544 - 52,529,183(+) GCGGT(A/T)CTGAA reference, missense, utr-variant-5-prime
rs4475032 -- 52,526,005(+) GGCCC(C/T)AGACC intron-variant
rs7614424 -- 52,532,338(+) CGGGC(C/T)CAGAG intron-variant, utr-variant-5-prime
rs7614981 -- 52,532,898(+) CATTT(A/C)TCAGA intron-variant, upstream-variant-2KB
rs58574369 -- 52,527,244(+) CCCTA(A/G)CTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NT5DC2 Gene

Variant ID Type Subtype PubMed ID
nsv876789 CNV Loss 21882294
nsv834697 CNV Loss 17160897
dgv5137n71 CNV Loss 21882294
nsv3820 CNV Insertion 18451855
dgv5138n71 CNV Loss 21882294
esv27812 CNV Loss 19812545

Variation tolerance for NT5DC2 Gene

Residual Variation Intolerance Score: 8.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.51; 85.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NT5DC2 Gene

Disorders for NT5DC2 Gene

Relevant External Links for NT5DC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NT5DC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5DC2 Gene

Publications for NT5DC2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3
  3. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for NT5DC2 Gene

Sources for NT5DC2 Gene