NT5DC1 Gene
protein-coding GIFtS: 45
GCID: GC06P116421
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5'-nucleotidase domain containing 1(Previous names: 5'-nucleotidase, cytosolic II-like 1 )
(Previous symbol: NT5C2L1)
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Aliases
for NT5DC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| 5'-Nucleotidase Domain Containing 11 2 | | 5'-Nucleotidase Domain-Containing Protein 12 | | NT5C2L11 2 3 | | 5'-Nucleotidase, Cytosolic II-Like 1 Protein2 | | 5'-Nucleotidase, Cytosolic II-Like 11 | | C6orf2002 | | MGC243021 | | LP26422 | | DJ486I3.11 | | EC 3.1.3.-3 |
Export aliases for NT5DC1 gene to outside databasesPrevious GC identifers: GC06P116529 GC06P114002 |
Summaries
for NT5DC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NT5DC1:
While the exact function of the protein encoded by this gene is not known, it belongs to the5'(3')-deoxyribonucleotidase family. (provided by RefSeq, May 2010)
|
Genomic Views
for NT5DC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NT5DC1 gene promoter:
Max1 AP-1 AML1a Meis-1b C/EBPalpha Evi-1 Meis-1a MRF-2 c-Myc Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NT5DC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NT5DC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q22.1 Ensembl cytogenetic band: 6q22.1 HGNC cytogenetic band: 6q22.31NT5DC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P116421: view genomic region
(about GC identifiers)
Start:
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116,421,999 bp from pter |
End:
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116,566,855 bp from pter |
Size:
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144,857 bases |
Orientation:
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plus strand |
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Proteins
for NT5DC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: NT5D1_HUMAN, Q5TFE4 (See
protein sequence)Recommended Name: 5'-nucleotidase domain-containing protein 1 Size: 455 amino acids; 51845 Da
Sequence caution: Sequence=AAP34458.1; Type=Frameshift; Positions=339;
Secondary accessions: B2RND9 Q6XYD5Explore the universe of human proteins at neXtProt for NT5DC1: NX_Q5TFE4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5TFE4
NT5DC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689942.2
ENSEMBL proteins: ENSP00000326858 ENSP00000393578 ENSP00000404419 ENSP00000433238
Human Recombinant Protein Products:
NT5DC1 Antibody Products:
Assay Products for NT5DC1: |
Protein
Domains /
Families
for NT5DC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NT5DC1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5TFE4ProtoNet protein and cluster: Q5TFE4 UniProtKB/Swiss-Prot: NT5D1_HUMAN, Q5TFE4Similarity: Belongs to the 5'(3')-deoxyribonucleotidase family |
Function
for NT5DC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 3.1.3.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NT5DC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NT5DC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NT5DC1 (NM_152729) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NT5DC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NT5DC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5DC1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016787 | hydrolase activity |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- |
NT5DC1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for NT5DC1:
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Pathways & Interactions
for NT5DC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NT5DC1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for NT5DC1 (Q5TFE43 ENSP000003268584) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for NT5DC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for NT5DC1
Search CenterWatch for drugs/clinical trials and news about NT5DC1 / NT5D1
|
Transcripts
for NT5DC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for NT5DC1 gene: NM_152729.2 Unigene Cluster for NT5DC1: 5'-nucleotidase domain containing 1 Hs.520341 [show with all ESTs]Unigene Representative Sequence: NM_1527294 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000319550(uc003pwj.3 uc003pwl.3) ENST00000419791 ENST00000417846
ENST00000460749
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NT5DC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NT5DC1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: NT5DC1 (NM_152729) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NT5DC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NT5DC1 |
Additional cDNA sequence: AF245044.1 AK090918.1 AK290408.1 AK308337.1 AY203935.1 BC015138.1 BC056664.1 BC063504.1 BC108699.1 BC136832.1 BC136841.1 11 DOTS entries: DT.91738067 DT.75140782 DT.121389710 DT.100743827 DT.100842548 DT.121389750 DT.95173000 DT.442992 DT.99977644 DT.95218743 DT.121389882 24/197 AceView cDNA sequences (see all 197): N20500 NM_152729 CA393858 AW198077 AI522095 AI651833 BQ774140 AI520684 AK090918 AA370094 CR612669 AA370420 BI858211 AA811820 AA765076 CA390074 H96287 AA053120 AA503740 AA370093 AA702170 AW513009 BM676990 BU686554
GeneLoc Exon Structure
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Expression
for NT5DC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NT5DC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGCTTTAA
About this image
See NT5DC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for NT5DC1
SOURCE GeneReport for Unigene cluster: Hs.520341
SABiosciences Custom PCR Arrays for NT5DC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NT5DC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NT5DC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NT5DC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NT5DC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5DC1 |
Orthologs
for NT5DC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for NT5DC1 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for NT5DC1 (if available)
TreeFam Gene Tree for NT5DC1 (if available) |
Paralogs
for NT5DC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for NT5DC1 gene
- NT5DC32 NT5C22 NT5DC22 NT5DC42
1 SIMAP similar gene for NT5DC1 using alignment to 6 protein entries: NT5D1_HUMAN (see all proteins):NT5DC3
NT5DC1 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for NT5DC1
PGOHUM00000235479 PGOHUM00000243406 PGOHUM00000241449 PGOHUM00000242022
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Genomic Variants
for NT5DC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for NT5DC1 (116421999 - 116566855 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NT5DC1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NT5DC1 |
|
Disorders
/ Diseases
for NT5DC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NT5DC1 for disorders About GeneDecksing
3  diseases for NT5DC1: About MalaCardscleft lip/palate cleft lip choroiditis
Human Genome Epidemiology (HuGE) Navigator: NT5DC1 (5 documents)
Export disorders for NT5DC1 gene to outside databases
|
Publications
for NT5DC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NT5DC1 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with NT5DC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Single-nucleotide polymorphisms in the TSPYL-4 and NT5 DC1 genes are associated with susceptibility to chronic obstructive pulmonary di sease. (PubMed id 22736055)1 Guo Y....Wan H. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
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External Searches for NT5DC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing NT5DC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NT5DC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NT5DC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for NT5DC1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for NT5DC1 gene:
Search GeneIP for patents involving NT5DC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NT5DC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for NT5DC1 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NT5DC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NT5DC1 | | | OriGene Protein Over-expression Lysate for NT5DC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for NT5DC1 | | OriGene 3'-UTR Clone for NT5DC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NT5DC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NT5DC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for NT5DC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for NT5DC1 | | OriGene Custom Protein Services for NT5DC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NT5DC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NT5DC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NT5DC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NT5DC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NT5DC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NT5DC1 |
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| | | | Search Tocris compounds for NT5DC1 |
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 | | | NT5DC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5DC1 |
|  |  |  | | | | ThermoFisher Antibodies for NT5DC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NT5DC1 |
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