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Aliases for NT5DC1 Gene

Aliases for NT5DC1 Gene

  • 5'-Nucleotidase Domain Containing 1 2
  • 5-Nucleotidase Domain Containing 1 2 3 5
  • NT5C2L1 3 4
  • 5-Nucleotidase, Cytosolic II-Like 1 Protein 3
  • 5-Nucleotidase, Cytosolic II-Like 1 2
  • EC 3.1.3.- 4
  • C6orf200 3
  • LP2642 3

External Ids for NT5DC1 Gene

Previous HGNC Symbols for NT5DC1 Gene

  • NT5C2L1

Previous GeneCards Identifiers for NT5DC1 Gene

  • GC06P116529
  • GC06P116421
  • GC06P114002

Summaries for NT5DC1 Gene

Entrez Gene Summary for NT5DC1 Gene

  • While the exact function of the protein encoded by this gene is not known, it belongs to the 5'(3')-deoxyribonucleotidase family. [provided by RefSeq, May 2010]

GeneCards Summary for NT5DC1 Gene

NT5DC1 (5'-Nucleotidase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity and 5-nucleotidase activity. An important paralog of this gene is NT5DC2.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5DC1 Gene

Genomics for NT5DC1 Gene

Regulatory Elements for NT5DC1 Gene

Enhancers for NT5DC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NT5DC1 on UCSC Golden Path with GeneCards custom track

Promoters for NT5DC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NT5DC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NT5DC1 Gene

Chromosome:
6
Start:
116,100,823 bp from pter
End:
116,249,497 bp from pter
Size:
148,675 bases
Orientation:
Plus strand

Genomic View for NT5DC1 Gene

Genes around NT5DC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5DC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5DC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5DC1 Gene

Proteins for NT5DC1 Gene

  • Protein details for NT5DC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TFE4-NT5D1_HUMAN
    Recommended name:
    5-nucleotidase domain-containing protein 1
    Protein Accession:
    Q5TFE4
    Secondary Accessions:
    • B2RND9
    • B3KR35
    • Q6XYD5

    Protein attributes for NT5DC1 Gene

    Size:
    455 amino acids
    Molecular mass:
    51845 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP34458.1; Type=Frameshift; Positions=339; Evidence={ECO:0000305};

    Alternative splice isoforms for NT5DC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NT5DC1 Gene

Proteomics data for NT5DC1 Gene at MOPED

Post-translational modifications for NT5DC1 Gene

  • Ubiquitination at Lys 154
  • Modification sites at PhosphoSitePlus

Other Protein References for NT5DC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NT5DC1 Gene

Domains & Families for NT5DC1 Gene

Protein Domains for NT5DC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TFE4

UniProtKB/Swiss-Prot:

NT5D1_HUMAN :
  • Belongs to the 5(3)-deoxyribonucleotidase family.
Family:
  • Belongs to the 5(3)-deoxyribonucleotidase family.
genes like me logo Genes that share domains with NT5DC1: view

No data available for Gene Families for NT5DC1 Gene

Function for NT5DC1 Gene

Enzyme Numbers (IUBMB) for NT5DC1 Gene

Gene Ontology (GO) - Molecular Function for NT5DC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008253 5-nucleotidase activity IBA --
genes like me logo Genes that share ontologies with NT5DC1: view
genes like me logo Genes that share phenotypes with NT5DC1: view

Animal Model Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5DC1 Gene

Localization for NT5DC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NT5DC1 Gene COMPARTMENTS Subcellular localization image for NT5DC1 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NT5DC1 Gene

Pathways & Interactions for NT5DC1 Gene

SuperPathways for NT5DC1 Gene

No Data Available

Interacting Proteins for NT5DC1 Gene

Gene Ontology (GO) - Biological Process for NT5DC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NT5DC1 Gene

Drugs & Compounds for NT5DC1 Gene

No Compound Related Data Available

Transcripts for NT5DC1 Gene

Unigene Clusters for NT5DC1 Gene

5-nucleotidase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NT5DC1 Gene

No ASD Table

Relevant External Links for NT5DC1 Gene

GeneLoc Exon Structure for
NT5DC1
ECgene alternative splicing isoforms for
NT5DC1

Expression for NT5DC1 Gene

mRNA expression in normal human tissues for NT5DC1 Gene

Protein differential expression in normal tissues from HIPED for NT5DC1 Gene

This gene is overexpressed in Tonsil (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NT5DC1 Gene



SOURCE GeneReport for Unigene cluster for NT5DC1 Gene Hs.520341

genes like me logo Genes that share expression patterns with NT5DC1: view

Protein tissue co-expression partners for NT5DC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NT5DC1 Gene

Orthologs for NT5DC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NT5DC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NT5DC1 35
  • 89.97 (n)
  • 90.27 (a)
NT5DC1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NT5DC1 35
  • 85.51 (n)
  • 90.5 (a)
NT5DC1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nt5dc1 35
  • 83.11 (n)
  • 80.8 (a)
Nt5dc1 16
Nt5dc1 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NT5DC1 35
  • 99.63 (n)
  • 99.78 (a)
NT5DC1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nt5dc1 35
  • 81.55 (n)
  • 80.26 (a)
oppossum
(Monodelphis domestica)
Mammalia NT5DC1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves NT5DC1 35
  • 74.01 (n)
  • 75.55 (a)
NT5DC1 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NT5DC1 36
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nt5dc1 35
  • 61.63 (n)
  • 63.11 (a)
nt5dc1 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001319 35
  • 45.16 (n)
  • 38.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2277 35
  • 47.07 (n)
  • 38.06 (a)
CG2277 36
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for NT5DC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5DC1 Gene

ENSEMBL:
Gene Tree for NT5DC1 (if available)
TreeFam:
Gene Tree for NT5DC1 (if available)

Paralogs for NT5DC1 Gene

Paralogs for NT5DC1 Gene

(1) SIMAP similar genes for NT5DC1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for NT5DC1 Gene

genes like me logo Genes that share paralogs with NT5DC1: view

Variants for NT5DC1 Gene

Sequence variations from dbSNP and Humsavar for NT5DC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1048920 -- 116,245,042(-) AATTA(C/T)ATTAA utr-variant-3-prime
rs1204795 -- 116,220,213(+) GCTTA(C/T)TAGTT intron-variant
rs1204796 -- 116,220,340(+) TCTGG(C/T)CAGGA intron-variant
rs1204797 -- 116,220,384(+) CTCAG(C/T)CAGAC intron-variant
rs1204798 -- 116,222,684(+) AGCCA(A/G)TTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NT5DC1 Gene

Variant ID Type Subtype PubMed ID
nsv523972 CNV Gain 19592680

Variation tolerance for NT5DC1 Gene

Residual Variation Intolerance Score: 53.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NT5DC1 Gene

HapMap Linkage Disequilibrium report
NT5DC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5DC1 Gene

Disorders for NT5DC1 Gene

Relevant External Links for NT5DC1

Genetic Association Database (GAD)
NT5DC1
Human Genome Epidemiology (HuGE) Navigator
NT5DC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NT5DC1

No disorders were found for NT5DC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5DC1 Gene

Publications for NT5DC1 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. GWAS of dental caries patterns in the permanent dentition. (PMID: 23064961) Shaffer J.R. … Marazita M.L. (J. Dent. Res. 2013) 3
  4. Seven new loci associated with age-related macular degeneration. (PMID: 23455636) Fritsche L.G. … Abecasis G.R. (Nat. Genet. 2013) 3
  5. Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease. (PMID: 22736055) Guo Y. … Wan H. (Mol Med Rep 2012) 3

Products for NT5DC1 Gene

Sources for NT5DC1 Gene

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