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Aliases for NT5C3B Gene

Aliases for NT5C3B Gene

  • 5'-Nucleotidase, Cytosolic IIIB 2
  • Cytosolic 5-Nucleotidase III-Like Protein 3 4
  • 5-Nucleotidase, Cytosolic III-Like 2 3
  • N(7)-Methylguanylate 5-Phosphatase 3 4
  • 5-Nucleotidase, Cytosolic IIIB 2 3
  • 7-Methylguanosine Nucleotidase 3 4
  • Cytosolic 5-Nucleotidase 3B 3 4
  • CN-III-Like Protein 3 4
  • NT5C3L 3 4
  • 7-Methylguanosine Phosphate-Specific 5-Nucleotidase 3
  • EC 4
  • EC 4

External Ids for NT5C3B Gene

Previous Symbols for NT5C3B Gene

  • NT5C3L

Summaries for NT5C3B Gene

GeneCards Summary for NT5C3B Gene

NT5C3B (5'-Nucleotidase, Cytosolic IIIB) is a Protein Coding gene. Among its related pathways are Metabolism and Purine metabolism (KEGG). GO annotations related to this gene include nucleotide binding and 5-nucleotidase activity. An important paralog of this gene is NT5C3A.

UniProtKB/Swiss-Prot for NT5C3B Gene

  • Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C3B Gene

Genomics for NT5C3B Gene

Genomic Location for NT5C3B Gene

41,825,082 bp from pter
41,836,271 bp from pter
11,190 bases
Minus strand

Genomic View for NT5C3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NT5C3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5C3B Gene

No data available for Regulatory Elements for NT5C3B Gene

Proteins for NT5C3B Gene

  • Protein details for NT5C3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    7-methylguanosine phosphate-specific 5-nucleotidase
    Protein Accession:
    Secondary Accessions:
    • A8MWB9
    • C9JKC4
    • Q7L3B7

    Protein attributes for NT5C3B Gene

    300 amino acids
    Molecular mass:
    34389 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for NT5C3B Gene


neXtProt entry for NT5C3B Gene

Proteomics data for NT5C3B Gene at MOPED

Post-translational modifications for NT5C3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NT5C3B Gene

No data available for DME Specific Peptides for NT5C3B Gene

Domains for NT5C3B Gene

Protein Domains for NT5C3B Gene


  • Belongs to the pyrimidine 5-nucleotidase family.:
    • Q969T7
genes like me logo Genes that share domains with NT5C3B: view

No data available for Gene Families for NT5C3B Gene

Function for NT5C3B Gene

Molecular function for NT5C3B Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=7.8 uM for m(7)GMP {ECO:0000269 PubMed:23223233}; KM=79 uM for CMP {ECO:0000269 PubMed:23223233}; KM=355 uM for GMP {ECO:0000269 PubMed:23223233}; KM=456 uM for AMP {ECO:0000269 PubMed:23223233}; KM=439 uM for UMP {ECO:0000269 PubMed:23223233}; Vmax=0.41 umol/min/mg enzyme with m(7)GMP as substrate {ECO:0000269 PubMed:23223233}; Vmax=12 umol/min/mg enzyme with CMP as substrate {ECO:0000269 PubMed:23223233}; Vmax=0.13 umol/min/mg enzyme with GMP as substrate {ECO:0000269 PubMed:23223233}; Vmax=0.07 umol/min/mg enzyme with AMP as substrate {ECO:0000269 PubMed:23223233}; Vmax=10.7 umol/min/mg enzyme with UMP as substrate {ECO:0000269 PubMed:23223233}; Note=kcat is 0.24 sec(-1) with m(7)GMP. kcat is 7 sec(-1) with CMP. kcat is 0.07 sec(-1) with GMP. kcat is 0.04 sec(-1) with AMP. kcat is 6.2 sec(-1) with UMP.;
UniProtKB/Swiss-Prot CatalyticActivity: N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: CMP + H(2)O = cytidine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity: A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
UniProtKB/Swiss-Prot Function: Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates.

Enzyme Numbers (IUBMB) for NT5C3B Gene

Gene Ontology (GO) - Molecular Function for NT5C3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0005515 protein binding IPI 20706999
GO:0008253 5-nucleotidase activity IEA --
genes like me logo Genes that share ontologies with NT5C3B: view

miRNA for NT5C3B Gene

miRTarBase miRNAs that target NT5C3B

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NT5C3B Gene

Localization for NT5C3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NT5C3B Gene


Gene Ontology (GO) - Cellular Components for NT5C3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NT5C3B: view

Pathways for NT5C3B Gene

genes like me logo Genes that share pathways with NT5C3B: view

Pathways by source for NT5C3B Gene

Interacting Proteins for NT5C3B Gene

Selected Interacting proteins: Q969T7-5NT3B_HUMAN for NT5C3B Gene via UniProtKB I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NT5C3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009117 nucleotide metabolic process IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NT5C3B: view

Transcripts for NT5C3B Gene

Unigene Clusters for NT5C3B Gene

5-nucleotidase, cytosolic IIIB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NT5C3B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: -
SP7: - - - -
SP8: - - - - - - -
SP9: - - - - - - - -
SP10: - - - - -
SP11: - -
SP12: - -

Relevant External Links for NT5C3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5C3B Gene

mRNA expression in normal human tissues for NT5C3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for NT5C3B Gene

SOURCE GeneReport for Unigene cluster for NT5C3B Gene Hs.237536

genes like me logo Genes that share expressions with NT5C3B: view

Orthologs for NT5C3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NT5C3B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NT5C3B 37
  • 99 (a)
NT5C3L 36
  • 99.67 (n)
  • 100 (a)
(Bos Taurus)
Mammalia NT5C3L 36
  • 90.08 (n)
  • 90.3 (a)
NT5C3L 37
  • 90 (a)
(Canis familiaris)
Mammalia NT5C3B 36
  • 91.53 (n)
  • 93.65 (a)
NT5C3B 37
  • 67 (a)
(Mus musculus)
Mammalia Nt5c3b 36
  • 87.29 (n)
  • 89.97 (a)
Nt5c3b 16
Nt5c3b 37
  • 90 (a)
(Monodelphis domestica)
Mammalia NT5C3B 37
  • 62 (a)
(Rattus norvegicus)
Mammalia Nt5c3b 36
  • 87.85 (n)
  • 90.3 (a)
(Gallus gallus)
Aves NT5C3B 37
  • 65 (a)
NT5C3L 36
  • 69.11 (n)
  • 65.16 (a)
(Anolis carolinensis)
Reptilia NT5C3B 37
  • 64 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398553 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5c3b 36
  • 68.41 (n)
  • 63.41 (a)
Str.14210 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010681 36
  • 51.5 (n)
  • 38.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3362 36
  • 52.36 (n)
  • 39.53 (a)
CG3362 37
  • 35 (a)
(Caenorhabditis elegans)
Secernentea F25B5.3 37
  • 28 (a)
Y10G11A.1 37
  • 36 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G38680 36
  • 48.5 (n)
  • 38.72 (a)
(Oryza sativa)
Liliopsida Os03g0648900 36
  • 49.49 (n)
  • 42.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3144 37
  • 45 (a)
Species with no ortholog for NT5C3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NT5C3B Gene

Gene Tree for NT5C3B (if available)
Gene Tree for NT5C3B (if available)

Paralogs for NT5C3B Gene

Paralogs for NT5C3B Gene

Selected SIMAP similar genes for NT5C3B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NT5C3B: view

Variants for NT5C3B Gene

Sequence variations from dbSNP and Humsavar for NT5C3B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1046403 - 41,827,568(-) CTCTG(C/T)GTGTG reference, missense, nc-transcript-variant
rs1046404 - 41,827,556(-) GAACT(C/G)TGGTT reference, missense, nc-transcript-variant
rs1046470 -- 41,825,258(-) ATTTT(C/T)TTCAA utr-variant-3-prime, nc-transcript-variant
rs1128966 -- 41,827,597(-) CAGCT(C/G)ATACA reference, synonymous-codon, nc-transcript-variant
rs1436440 -- 41,824,879(+) CACAC(A/G)AATGC downstream-variant-500B

Relevant External Links for NT5C3B Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for NT5C3B Gene

Disorders for NT5C3B Gene

No disorders were found for NT5C3B Gene.

No data available for UniProtKB/Swiss-Prot for NT5C3B Gene

Publications for NT5C3B Gene

  1. Identification of Drosophila and Human 7-Methyl GMP-specific Nucleotidases. (PMID: 23223233) Buschmann J. … Wahle E. (J. Biol. Chem. 2013) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4
  4. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 4
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for NT5C3B Gene

Sources for NT5C3B Gene

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