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Aliases for NT5C3B Gene

Aliases for NT5C3B Gene

  • 5'-Nucleotidase, Cytosolic IIIB 2
  • 5-Nucleotidase, Cytosolic IIIB 2 3 5
  • Cytosolic 5-Nucleotidase III-Like Protein 3 4
  • 5-Nucleotidase, Cytosolic III-Like 2 3
  • N(7)-Methylguanylate 5-Phosphatase 3 4
  • 7-Methylguanosine Nucleotidase 3 4
  • Cytosolic 5-Nucleotidase 3B 3 4
  • CN-III-Like Protein 3 4
  • NT5C3L 3 4
  • EC 3.1.3.91 4
  • EC 3.1.3.5 4
  • CN-IIIB 3

External Ids for NT5C3B Gene

Previous HGNC Symbols for NT5C3B Gene

  • NT5C3L

Previous GeneCards Identifiers for NT5C3B Gene

  • GC17M039982

Summaries for NT5C3B Gene

GeneCards Summary for NT5C3B Gene

NT5C3B (5'-Nucleotidase, Cytosolic IIIB) is a Protein Coding gene. Diseases associated with NT5C3B include lynch syndrome. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include nucleotide binding and 5-nucleotidase activity. An important paralog of this gene is NT5C3A.

UniProtKB/Swiss-Prot for NT5C3B Gene

  • Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C3B Gene

Genomics for NT5C3B Gene

Regulatory Elements for NT5C3B Gene

Promoters for NT5C3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NT5C3B on UCSC Golden Path with GeneCards custom track

Genomic Location for NT5C3B Gene

Chromosome:
17
Start:
41,825,082 bp from pter
End:
41,836,271 bp from pter
Size:
11,190 bases
Orientation:
Minus strand

Genomic View for NT5C3B Gene

Genes around NT5C3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5C3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5C3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5C3B Gene

Proteins for NT5C3B Gene

  • Protein details for NT5C3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969T7-5NT3B_HUMAN
    Recommended name:
    7-methylguanosine phosphate-specific 5-nucleotidase
    Protein Accession:
    Q969T7
    Secondary Accessions:
    • A8MWB9
    • C9JKC4
    • Q7L3B7

    Protein attributes for NT5C3B Gene

    Size:
    300 amino acids
    Molecular mass:
    34389 Da
    Quaternary structure:
    • Monomer.

    Alternative splice isoforms for NT5C3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NT5C3B Gene

Proteomics data for NT5C3B Gene at MOPED

Post-translational modifications for NT5C3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NT5C3B Gene

No data available for DME Specific Peptides for NT5C3B Gene

Domains & Families for NT5C3B Gene

Protein Domains for NT5C3B Gene

Suggested Antigen Peptide Sequences for NT5C3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969T7

UniProtKB/Swiss-Prot:

5NT3B_HUMAN :
  • Belongs to the pyrimidine 5-nucleotidase family.
Family:
  • Belongs to the pyrimidine 5-nucleotidase family.
genes like me logo Genes that share domains with NT5C3B: view

No data available for Gene Families for NT5C3B Gene

Function for NT5C3B Gene

Molecular function for NT5C3B Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.8 uM for m(7)GMP (at 37 degrees Celsius) {ECO:0000269 PubMed:23223233}; KM=8 uM for m(7)GMP (at 37 degrees Celsius) {ECO:0000269 PubMed:24603684}; KM=79 uM for CMP (at 37 degrees Celsius) {ECO:0000269 PubMed:23223233, ECO:0000269 PubMed:24603684}; KM=355 uM for GMP (at 37 degrees Celsius) {ECO:0000269 PubMed:23223233}; KM=456 uM for AMP (at 37 degrees Celsius) {ECO:0000269 PubMed:23223233}; KM=439 uM for UMP (at 37 degrees Celsius) {ECO:0000269 PubMed:23223233}; Vmax=0.41 umol/min/mg enzyme with m(7)GMP as substrate {ECO:0000269 PubMed:23223233}; Vmax=12 umol/min/mg enzyme with CMP as substrate {ECO:0000269 PubMed:23223233}; Vmax=0.13 umol/min/mg enzyme with GMP as substrate {ECO:0000269 PubMed:23223233}; Vmax=0.07 umol/min/mg enzyme with AMP as substrate {ECO:0000269 PubMed:23223233}; Vmax=10.7 umol/min/mg enzyme with UMP as substrate {ECO:0000269 PubMed:23223233}; Note=kcat is 0.24 sec(-1) with m(7)GMP. kcat is 7 sec(-1) with CMP. kcat is 0.07 sec(-1) with GMP. kcat is 0.04 sec(-1) with AMP. kcat is 6.2 sec(-1) with UMP.;
UniProtKB/Swiss-Prot CatalyticActivity:
N(7)-methyl-GMP + H(2)O = N(7)-methyl-guanosine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
CMP + H(2)O = cytidine + phosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
UniProtKB/Swiss-Prot Function:
Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate (PubMed:23223233, PubMed:24603684). The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids (PubMed:23223233). Also has weak activity for CMP (PubMed:23223233, PubMed:24603684). UMP and purine nucleotides are poor substrates (PubMed:23223233).

Enzyme Numbers (IUBMB) for NT5C3B Gene

genes like me logo Genes that share phenotypes with NT5C3B: view

Animal Model Products

miRNA for NT5C3B Gene

miRTarBase miRNAs that target NT5C3B

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5C3B Gene

Localization for NT5C3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NT5C3B Gene

Cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for NT5C3B Gene

Pathways & Interactions for NT5C3B Gene

genes like me logo Genes that share pathways with NT5C3B: view

Interacting Proteins for NT5C3B Gene

Selected Interacting proteins: Q969T7-5NT3B_HUMAN for NT5C3B Gene via UniProtKB I2D

Symbol External ID(s) Details
MLH1

Gene Ontology (GO) - Biological Process for NT5C3B Gene

None

No data available for SIGNOR curated interactions for NT5C3B Gene

Drugs & Compounds for NT5C3B Gene

(1) Drugs for NT5C3B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ergocalciferol Approved Nutra 923

(2) Additional Compounds for NT5C3B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with NT5C3B: view

Transcripts for NT5C3B Gene

Unigene Clusters for NT5C3B Gene

5-nucleotidase, cytosolic IIIB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NT5C3B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b
SP1: - - - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6: -
SP7: - - - -
SP8: - - - - - - -
SP9: - - - - - - - -
SP10: - - - - -
SP11: - -
SP12: - -
SP13:

Relevant External Links for NT5C3B Gene

GeneLoc Exon Structure for
NT5C3B
ECgene alternative splicing isoforms for
NT5C3B

Expression for NT5C3B Gene

mRNA expression in normal human tissues for NT5C3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NT5C3B Gene

This gene is overexpressed in Skin (16.7), Uterus (8.2), and Salivary gland (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for NT5C3B Gene



SOURCE GeneReport for Unigene cluster for NT5C3B Gene Hs.237536

genes like me logo Genes that share expression patterns with NT5C3B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for NT5C3B Gene

Orthologs for NT5C3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NT5C3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NT5C3B 36
  • 99 (a)
OneToOne
NT5C3L 35
  • 99.67 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia NT5C3L 35
  • 90.08 (n)
  • 90.3 (a)
NT5C3L 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NT5C3B 36
  • 67 (a)
OneToOne
NT5C3B 35
  • 91.53 (n)
  • 93.65 (a)
mouse
(Mus musculus)
Mammalia Nt5c3b 16
Nt5c3b 36
  • 90 (a)
OneToOne
Nt5c3b 35
  • 87.29 (n)
  • 89.97 (a)
oppossum
(Monodelphis domestica)
Mammalia NT5C3B 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nt5c3b 35
  • 87.85 (n)
  • 90.3 (a)
chicken
(Gallus gallus)
Aves NT5C3L 35
  • 69.11 (n)
  • 65.16 (a)
NT5C3B 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NT5C3B 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398553 35
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5c3b 35
  • 68.41 (n)
  • 63.41 (a)
Str.14210 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010681 35
  • 51.5 (n)
  • 38.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3362 35
  • 52.36 (n)
  • 39.53 (a)
CG3362 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F25B5.3 36
  • 28 (a)
ManyToMany
Y10G11A.1 36
  • 36 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G38680 35
  • 48.5 (n)
  • 38.72 (a)
rice
(Oryza sativa)
Liliopsida Os03g0648900 35
  • 49.49 (n)
  • 42.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3144 36
  • 45 (a)
OneToMany
Species with no ortholog for NT5C3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for NT5C3B Gene

ENSEMBL:
Gene Tree for NT5C3B (if available)
TreeFam:
Gene Tree for NT5C3B (if available)

Paralogs for NT5C3B Gene

Paralogs for NT5C3B Gene

(1) SIMAP similar genes for NT5C3B Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with NT5C3B: view

Variants for NT5C3B Gene

Sequence variations from dbSNP and Humsavar for NT5C3B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1046403 - 41,827,568(-) CTCTG(C/T)GTGTG intron-variant, nc-transcript-variant, reference, missense
rs1046404 - 41,827,556(-) GAACT(C/G)TGGTT intron-variant, nc-transcript-variant, reference, missense
rs1836878 -- 41,830,402(-) CCTCC(C/T)GAGTA intron-variant
rs1836879 -- 41,830,325(-) TCACC(A/G)TGTTG intron-variant
rs1836880 -- 41,830,232(-) CGCCC(A/G)GCCAA intron-variant

Variation tolerance for NT5C3B Gene

Residual Variation Intolerance Score: 38.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NT5C3B Gene

HapMap Linkage Disequilibrium report
NT5C3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NT5C3B Gene

Disorders for NT5C3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for NT5C3B Gene - From: GeneCards

Disorder Aliases PubMed IDs
lynch syndrome
  • coca 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NT5C3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NT5C3B
genes like me logo Genes that share disorders with NT5C3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NT5C3B Gene

Publications for NT5C3B Gene

  1. Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP. (PMID: 24603684) Monecke T. … Ficner R. (PLoS ONE 2014) 2 3 4 67
  2. Identification of Drosophila and Human 7-Methyl GMP-specific Nucleotidases. (PMID: 23223233) Buschmann J. … Wahle E. (J. Biol. Chem. 2013) 2 3
  3. Novel genes for airway wall thickness identified with combined genome-wide association and expression analyses. (PMID: 25517131) Dijkstra A.E. … Groen H.J. (Am. J. Respir. Crit. Care Med. 2015) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Cytoskeletal scaffolding proteins interact with Lynch-Syndrome associated mismatch repair protein MLH1. (PMID: 20706999) Brieger A. … Trojan J. (Proteomics 2010) 3

Products for NT5C3B Gene

Sources for NT5C3B Gene

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