NT5C3 Gene

Aliases
for NT5C3 gene

Previous GC identifers: GC07M032696 GC07M032795 GC07M032826 GC07M033020 GC07M032932

Summaries
for NT5C3 gene

Genomic Views
for NT5C3 gene

RefSeq DNA sequence:

NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  

SwitchGear Promoter luciferase reporter plasmids (see all 2): NT5C3 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NT5C3

NT5C3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M033053:  view genomic region     (about GC identifiers)

Proteins
for NT5C3 gene

3 PDB 3D structures from and Proteopedia for NT5C3:

2CN1 (3D)        2JGA (3D)        2VKQ (3D)    

Explore the universe of human proteins at neXtProt for NT5C3: NX_Q9H0P0

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): NT5C3 OriGene Protein Over-expression Lysate (see all 4): NT5C3 OriGene Custom Protein Services for NT5C3
	GenScript Custom Purified and Recombinant Proteins Services for NT5C3
	Novus Biologicals NT5C3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for NT5C3

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for NT5C3
	GenScript Custom Superior Antibodies Services for NT5C3
	Novus Biologicals NT5C3 Antibodies
	Abcam antibodies for NT5C3
	Uscn Antibodies for NT5C3
	Search ThermoFisher Antibodies for NT5C3

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NT5C3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NT5C3

Protein Domains /
Families
for NT5C3 gene

ProtoNet protein and cluster: Q9H0P0

Function
for NT5C3 gene

     Enzyme Number (IUBMB): EC 3.1.3.5^{1 2}

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for NT5C3

miRNA Products:		miRTarBase miRNAs that target NT5C3: hsa-mir-30a (MIRT005184)
		OriGene 3'-UTR Clone (see all 3): NT5C3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NT5C3
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate NT5C3 (see all 9):
		hsa-miR-152 hsa-miR-520f hsa-miR-576-5p hsa-miR-148b hsa-miR-1283 hsa-miR-122 hsa-miR-145 hsa-miR-340
		SwitchGear 3'UTR luciferase reporter plasmid: NT5C3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NT5C3 (see all 7) OriGene shRNA RFP: NT5C3 OriGene siRNA: NT5C3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NT5C3
		Sirion Biotech Custom design and validation of potent shRNA sequences against NT5C3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for NT5C3
			Sirion Biotech Customized adenovirus for overexpression of NT5C3  Sirion Biotech Customized adenovirus for potent knockdown of NT5C3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NT5C3 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NT5C3 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): NT5C3 (NM_001002010)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for NT5C3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NT5C3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for NT5C3
		Search LifeMap BioReagents cell lines for NT5C3
		Sirion Biotech Customized stable knockdown cell line services for NT5C3  Sirion Biotech Customized inducible knockdown cell line services for NT5C3 Sirion Biotech Customized stable overexpressing cell line services for NT5C3 Sirion Biotech Customized inducible overexpressing cell line services for NT5C3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5C3

Pathways & Interactions
for NT5C3 gene

	Super-pathway	contained gene-specific pathways
1	NAD metabolism	NAD metabolism 1.00 Nicotinate and nicotinamide metabolism 0.43 NAD metabolism 1.00
2	Pyrimidine metabolism	Pyrimidine metabolism 1.00 Pyrimidine catabolism 0.50
3	Metabolism	Metabolism 1.00 Metabolic pathways 0.38
4	Purine metabolism	Purine metabolism 1.00 Pyrimidine metabolism 0.38
5	purine nucleotides degradation II (aerobic)	purine nucleotides degradation II (aerobic) 1.00 adenosine nucleotides degradation II 0.67

1 EMD Millipore Pathway for NT5C3

NAD metabolism

1 GeneGo (Thomson Reuters) Pathway for NT5C3

NAD metabolism

2 BioSystems Pathways for NT5C3

	adenosine nucleotides degradation II
	purine nucleotides degradation II (aerobic)

4        Reactome Pathways for NT5C3

	Metabolism of nucleotides
	Metabolism
	Pyrimidine catabolism
	Pyrimidine metabolism

4         Kegg Pathways  (Kegg details for NT5C3)

	Purine metabolism
	Pyrimidine metabolism
	Nicotinate and nicotinamide metabolism
	Metabolic pathways

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for NT5C3 gene

Transcripts
for NT5C3 gene

Expression
for NT5C3 gene

NT5C3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTTAAGTA

About this image

NT5C3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LiverLiver Lobule			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NT5C3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NT5C3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NT5C3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NT5C3

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5C3

Orthologs
for NT5C3 gene

Paralogs
for NT5C3 gene

Paralogs for NT5C3 gene

NT5C3B²  

1 SIMAP similar gene for NT5C3 using alignment to 4 protein entries:     5NT3_HUMAN (see all proteins):

NT5C3B

NT5C3 for paralogs           About GeneDecksing


2 Pseudogenes.org Pseudogenes for NT5C3
PGOHUM00000238133 PGOHUM00000245669

Genomic Variants
for NT5C3 gene

10/924 NCBI SNPs in NT5C3 are shown (see all 924)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1048940291,2	C	pathogenic	33099902(-)	CCCAAC/GGAGAC	8	R G	mis1		0	--	--	--	--
rs1048940281,2	C	pathogenic	33101622(-)	GTCCAA/GTTTTA	8	N S	mis1		0	--	--	--	--
rs1048940271,2	C	pathogenic	33101648(-)	GTTTAG/TCATCC	8	* Y	stg1		0	--	--	--	--
rs1048940251,2	C	pathogenic	33105476(-)	AGTTGA/TTCCTG	8	D V	mis1		0	--	--	--	--
rs672138401,2	C	--	32950852(+)	CCTGTT/-AATCC	4	--	int1		1		NA	2
rs64624461,2	C,F,A,H	--	33053281(+)	ATCACA/GGTCAA	4	--	ds5001		29		NA NS EA WA CSA	2916
rs1162156661,2		--	33053376(+)	AGAGAT/AGCTGG	4	--	ds5001		1		WA	118
rs1908208451,2		--	33053420(+)	ACCACA/GAGACC	4	--	ds5001		0	--	--	--	--
rs1473222161,2		--	33053432(+)	AGCTCC/TACTGC	4	--	ds5001		0	--	--	--	--
rs1393811231,2		--	33053495(+)	AAATGA/GGAGAA	4	--	ds5001		0	--	--	--	--

HapMap Linkage Disequilibrium report for NT5C3 (33053742 - 33102409 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for NT5C3: --
Human Gene Mutation Database (HGMD): NT5C3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NT5C3

DNA2.0 Custom Variant and Variant Library Synthesis for NT5C3

Disorders / Diseases
for NT5C3 gene

13 diseases for NT5C3

2 Novoseek disease relationships for NT5C3 gene    About this table

Publications
for NT5C3 gene

PubMed articles for NT5C3 gene, integrated from 9 sources (see all 42): (articles sorted by number of sources associating them with NT5C3)

Utopia: connect your pdf to the dynamic world of online information

1. Human erythrocyte pyrimidine 5-nucleotidase, PN-I, is identical to p36, a protein associated to lupus inclusion formation in response to alpha-interferon. (PubMed id 10942414)^{1, 2, 3, 9} Amici A....Magni G. (2000)
2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)^{1, 2, 3} Zhang Q.-H.... Chen Z. (2000)
3. Genetic basis of hemolytic anemia caused by pyrimidine 5' nucleotidase deficiency. (PubMed id 11369620)^{1, 2, 9} Marinaki A.M.... Rees D.C. (2001)
4. Purification, microsequencing, and immunolocalization of p36, a new interferon-alpha-induced protein that is associated with human lupus inclusions. (PubMed id 8557639)^{1, 2, 9} Rich S.A.... Rudofsky U.H. (1996)
5. Molecular characterization of six unrelated Italian patients affected by pyrimidine 5'-nucleotidase deficiency. (PubMed id 12930399)^{1, 2, 9} Bianchi P.... Zanella A. (2003)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
7. Molecular basis of Japanese variants of pyrimidine 5'-nucleotidase deficiency. (PubMed id 15238149)^{1, 2} Kanno H.... Fujii H. (2004)
8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
9. Cytosolic 5'-nucleotidase III (NT5C3): gene sequence variation and functional genomics. (PubMed id 19623099)^{1, 9} Aksoy P....Wang L. (2009)
10. Human erythrocyte pyrimidine 5'-nucleotidase, PN-I. (PubMed id 11795870)^{1, 9} Amici A. and Magni G. (2002)

External Searches for NT5C3 gene

Genome Databases showing NT5C3 gene

Other Databases showing NT5C3 gene

Specialized Databases showing NT5C3 gene

Products
for NT5C3 gene