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NT5C1B-RDH14 Gene

protein-coding   GIFtS: 23
GCID: GC02M018737

NT5C1B-RDH14 Readthrough

  Search for NT5C1B-RDH14
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
NT5C1B-RDH14 Readthrough1 2
NT5C1B-RDH14 Protein2
NT5C1B-RDH14 Read-Through Transcript2

External Ids:    HGNC: 388311   Entrez Gene: 1005267942   Ensembl: ENSG000002507417   UniProtKB: C9J2C74   

Export aliases for NT5C1B-RDH14 gene to outside databases

Previous GC identifer: GC02U902251


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NT5C1B-RDH14 Gene:
This locus represents naturally occurring read-through transcription between the neighboring NT5C1B
(5'-nucleotidase, cytosolic IB) and RDH14 (retinol dehydrogenase 14) genes on chromosome 2. Alternative splicing
results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with
the products of each individual gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for NT5C1B-RDH14 Gene:
NT5C1B-RDH14 (NT5C1B-RDH14 readthrough) is a protein-coding gene. An important paralog of this gene is NT5C1A.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for NT5C1B-RDH14
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NT5C1B-RDH14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p   Ensembl cytogenetic band:  2p24.2   HGNC cytogenetic band: 2p24.2

NT5C1B-RDH14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NT5C1B-RDH14 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M018737:  view genomic region     (about GC identifiers)

Start:
18,735,989 bp from pter      End:
18,770,846 bp from pter
Size:
34,858 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/TrEMBL: C9J2C7 (See protein sequence)
Recommended Name: Protein NT5C1B-RDH14  
Size: 533 amino acids; 60169 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

REFSEQ proteins (2 alternative transcripts): 
NP_001186032.1  NP_001186033.1  

ENSEMBL proteins: 
 ENSP00000433415   ENSP00000412639  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR010394 5-nucleotidase
 IPR016040 NAD(P)-bd_dom

Graphical View of Domain Structure for InterPro Entry C9J2C7

ProtoNet protein and cluster: C9J2C7


NT5C1B-RDH14 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000166nucleotide binding ----
GO:0000287magnesium ion binding ----
GO:00082535'-nucleotidase activity ----
GO:0016491oxidoreductase activity ----
     
NT5C1B-RDH14 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----

NT5C1B-RDH14 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for NT5C1B-RDH14 About    
See pathways by source

SuperPathContained pathways About
1Purine metabolism (KEGG)
Purine metabolism0.38
Pyrimidine metabolism0.38
2Nicotinate and nicotinamide metabolism
Nicotinate and nicotinamide metabolism0.43
3Metabolism
Metabolic pathways0.38

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



4 Kegg Pathways  (Kegg details for NT5C1B-RDH14):
    Purine metabolism
Pyrimidine metabolism
Nicotinate and nicotinamide metabolism
Metabolic pathways


NT5C1B-RDH14 for pathways           About GeneDecksing

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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008152metabolic process ----
GO:0009117nucleotide metabolic process ----

NT5C1B-RDH14 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for NT5C1B-RDH14 gene (2 alternative transcripts): 
NM_001199103.1  NM_001199104.1  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000532967(uc002rcy.3) ENST00000444297(uc010exr.3)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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NT5C1B-RDH14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
NT5C1B-RDH14 Expression
About this image

NT5C1B-RDH14 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for NT5C1B-RDH14 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
68(a)
1 → many
3(100224719-100231095)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
67(a)
1 → many
1(153748565-153761810)
zebrafish
(Danio rerio)
Actinopterygii nt5c1bb6
nt5c1ba6
(see all 3)
5'-nucleotidase, cytosolic IB a
(see all 3)
62(a)
57(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
20(9455291-9479200) ENSDARG00000033742
13(32669771-32677534) ENSDARG00000018153
        Species with no ortholog for NT5C1B-RDH14

ENSEMBL Gene Tree for NT5C1B-RDH14 (if available)
TreeFam Gene Tree for NT5C1B-RDH14 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for NT5C1B-RDH14 gene
NT5C1A2  NT5C1B2  
5 SIMAP similar genes for NT5C1B-RDH14 using alignment to 1 protein entry:     C9J2C7_HUMAN:
DHRSX    NT5C1A    NT5C1B    RDH11    RDH14

NT5C1B-RDH14 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 4 variations for NT5C1B-RDH14:    About this table    
Variant IDTypeSubtypePubMed ID
esv2229780CNV Deletion18987734
nsv2624CNV Insertion18451855
nsv519085CNV Loss19592680
esv2751837CNV Gain17911159

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for NT5C1B-RDH14 gene integrated from 10 sources:
(articles sorted by number of sources associating them with NT5C1B-RDH14)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 100526794 HGNC: 38831 Ensembl:ENSG00000250741 euGenes: HUgn100526794 ECgene: NT5C1B-RDH14 Kegg: 100526794
H-InvDB: NT5C1B-RDH14

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for NT5C1B-RDH14 gene:
Search GeneIP for patents involving NT5C1B-RDH14

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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