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NT5C1B Gene

protein-coding   GIFtS: 52
GCID: GC02M018744

5'-Nucleotidase, Cytosolic IB

  See NT5C1B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5'-Nucleotidase, Cytosolic IB1 2     Cytosolic 5'-Nucleotidase 1B2
AIRP2 3 5     EC 3.1.3.53
Autoimmune Infertility-Related Protein2 3     cN-IB3
CN1B2 5     cN1B3
CN-IB2     Cytosolic 5'-Nucleotidase IB3

External Ids:    HGNC: 178181   Entrez Gene: 930342   Ensembl: ENSG000001850137   OMIM: 6105265   UniProtKB: Q96P263   

Export aliases for NT5C1B gene to outside databases

Previous GC identifers: GC02M018630 GC02M018711 GC02M018728 GC02M018657 GC02M018665 GC02M018599 GC02M018607


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NT5C1B Gene:
Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse
physiologic processes (Sala-Newby and Newby, 2001 (PubMed 11690631)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NT5C1B Gene:
NT5C1B (5'-nucleotidase, cytosolic IB) is a protein-coding gene. Diseases associated with NT5C1B include infertility. GO annotations related to this gene include 5'-nucleotidase activity and nucleotide binding. An important paralog of this gene is NT5C1A.

UniProtKB/Swiss-Prot: 5NT1B_HUMAN, Q96P26
Function: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine
levels (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the NT5C1B gene promoter:
         Nkx3-1   E2F-4   E2F-3a   E2F-5   Nkx3-1 v1   E2F-2   Evi-1   E2F   E2F-1   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNT5C1B promoter sequence
   Search Chromatin IP Primers for NT5C1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NT5C1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p24.2   Ensembl cytogenetic band:  2p24.2   HGNC cytogenetic band: 2p24.2

NT5C1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NT5C1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M018744:  view genomic region     (about GC identifiers)

Start:
18,737,050 bp from pter      End:
18,770,846 bp from pter
Size:
33,797 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: 5NT1B_HUMAN, Q96P26 (See protein sequence)
Recommended Name: Cytosolic 5'-nucleotidase 1B  
Size: 610 amino acids; 68804 Da
Cofactor: Magnesium (By similarity)
Sequence caution: Sequence=AAK39108.1; Type=Erroneous initiation; Sequence=AAK83285.1; Type=Frameshift;
Positions=320; Sequence=BAC04103.1; Type=Erroneous initiation; Sequence=CAC44363.1; Type=Erroneous initiation;
Secondary accessions: B5MCR0 B7ZVX7 Q53RX2 Q8N9W3 Q8NA26 Q96DU5 Q96KE6 Q96M25 Q96SA3
Alternative splicing: 4 isoforms:  Q96P26-1   Q96P26-2   Q96P26-3   Q96P26-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NT5C1B: NX_Q96P26

Explore proteomics data for NT5C1B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NT5C1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001002006.1  NP_001186015.1  NP_001186016.1  NP_001186017.1  NP_150278.2  

    ENSEMBL proteins: 
     ENSP00000305979   ENSP00000383905   ENSP00000352904   ENSP00000390811   ENSP00000401656  
     ENSP00000471357  
    Reactome Protein details: Q96P26

    NT5C1B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for NT5C1B

     
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    Search eBioscience for ELISAs for NT5C1B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: 5a-nucleotidase IB
    Adenosine turnover

    1 InterPro protein domain:
     IPR010394 5-nucleotidase

    Graphical View of Domain Structure for InterPro Entry Q96P26

    ProtoNet protein and cluster: Q96P26

    1 Blocks protein domain: IPB010394 5-nucleotidase

    UniProtKB/Swiss-Prot: 5NT1B_HUMAN, Q96P26
    Similarity: Belongs to the 5'-nucleotidase type 3 family


    Find genes that share domains with NT5C1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5NT1B_HUMAN, Q96P26
    Function: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine
    levels (By similarity)
    Catalytic activity: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate
    Enzyme regulation: Activated by ADP (By similarity)

         Enzyme Number (IUBMB): EC 3.1.3.51

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0000287magnesium ion binding IEA--
    GO:00082535'-nucleotidase activity IEA--
         
    Find genes that share ontologies with NT5C1B           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for NT5C1B:
     Decreased TP53 protein express  Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NT5C1B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NT5C1B
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    miRNA
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    miRTarBase miRNAs that target NT5C1B:
    hsa-mir-30a-5p (MIRT028508), hsa-mir-1 (MIRT023712), hsa-mir-124-3p (MIRT022553)

    Block miRNA regulation of human, mouse, rat NT5C1B using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate NT5C1B:
    hsa-miR-3671 hsa-miR-4279 hsa-miR-573 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-3647-3p hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidNT5C1B 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat NT5C1B

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5C1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5NT1B_HUMAN, Q96P26: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with NT5C1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NT5C1B About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    2Nicotinate and nicotinamide metabolism
    Nicotinate and nicotinamide metabolism0.43
    NAD metabolism0.43
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4Purine metabolism (REACTOME)
    Purine metabolism0.42
    Purine catabolism0.00
    Metabolism of nucleotides0.42


    Find genes that share SuperPaths with NT5C1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for NT5C1B
        NAD metabolism
    ATP/ITP metabolism

    1 Reactome Pathway for NT5C1B
        Purine catabolism


    4 Kegg Pathways  (Kegg details for NT5C1B):
        Purine metabolism
    Pyrimidine metabolism
    Nicotinate and nicotinamide metabolism
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NT5C1B
    Interactions:

        Search GeneGlobe Interaction Network for NT5C1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NT5C1B (ENSP000003529044) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADKENSP000002866214STRING: ENSP00000286621
    ADSLENSP000002161944STRING: ENSP00000216194
    ADSSENSP000003554934STRING: ENSP00000355493
    AMPD1ENSP000003165204STRING: ENSP00000316520
    ATICENSP000002369594STRING: ENSP00000236959
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006144purine nucleobase metabolic process TAS--
    GO:0006195purine nucleotide catabolic process TAS--
    GO:0009117nucleotide metabolic process ----
    GO:0044281small molecule metabolic process TAS--
    GO:0055086nucleobase-containing small molecule metabolic process TAS--

    Find genes that share ontologies with NT5C1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NT5C1B (5NT1B)

    Selected HMDB Compounds for NT5C1B (see all 28)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2'-Deoxyguanosine 5'-monophosphate2'-Deoxy-5'-GMP (see all 21)902-04-5--
    5-Thymidylic acid2'-Deoxythymidine 5'-monophosphate (see all 28)365-07-1--
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Deoxyadenosine1-(6-amino-9H-purin-9-yl)-1,2-dideoxy-b-D-Ribofuranose (see all 22)958-09-8--
    Deoxyadenosine monophosphate2'-Deoxy-5'-adenylate (see all 24)653-63-4--
    Deoxycytidine1-(2-Deoxy-b-D-ribofuranosyl)cytosine (see all 15)951-77-9--
    Deoxyguanosine2'-Deoxyguanosine (see all 11)961-07-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for NT5C1B gene (5 alternative transcripts): 
    NM_001002006.2  NM_001199086.1  NM_001199087.1  NM_001199088.1  NM_033253.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304081(uc010yju.2 uc002rcz.3 uc010yjw.2 uc010yjv.2 uc010exs.3 uc002rda.3)
    ENST00000406971 ENST00000359846 ENST00000418427 ENST00000490687(uc002rdb.1)
    ENST00000416783 ENST00000460052 ENST00000600945
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate NT5C1B:
    hsa-miR-3671 hsa-miR-4279 hsa-miR-573 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-3647-3p hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmidNT5C1B 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat NT5C1B

    Selected AceView cDNA sequences (see all 136):

    BC009830 AI570292 CR612704 AA926945 AK093234 AI261840 NM_033253 AA886674 
    AI954386 CR597110 BU076588 AK057444 AI952491 N76631 AI570797 NM_001002006 
    AF352326 CR619475 AA864535 AI085960 AA774597 AI041525 AX748003 BM548950 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NT5C1B (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                                                          -                                       
    SP2:                                -                                                                                 
    SP3:                    -           -                                                                                 
    SP4:                    -           -                                                                                 
    SP5:                    -                                                                                             


    ECgene alternative splicing isoforms for NT5C1B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NT5C1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    NT5C1B Expression
    About this image

    NT5C1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NT5C1B Protein Expression

    UniProtKB/Swiss-Prot: 5NT1B_HUMAN, Q96P26
    Tissue specificity: Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney,
    liver and lung

        Custom PCR Arrays for NT5C1B
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    QuantiFast Probe-based Assays in human, mouse, rat NT5C1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5C1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NT5C1B gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nt5c1b1 , 5 5'-nucleotidase, cytosolic IB1, 5 77.42(n)1
    75.5(a)1
      12 (5.27 cM)5
    708811  NM_027588.31  NP_081864.21 
     103699735 
    chicken
    (Gallus gallus)
    Aves NT5C1B1 5'-nucleotidase, cytosolic IB 75.08(n)
    76.62(a)
      421954  XM_419966.4  XP_419966.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    1 → many
    1(153748565-153761810)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia nt5c1a1 5'-nucleotidase, cytosolic IA 68.73(n)
    72.45(a)
      394700  NM_203765.1  NP_989096.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nt5c1bb1 5'-nucleotidase, cytosolic IB b 66.05(n)
    70.25(a)
      561683  XM_685092.6  XP_690184.1 


    ENSEMBL Gene Tree for NT5C1B (if available)
    TreeFam Gene Tree for NT5C1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NT5C1B gene
    NT5C1A2  NT5C1B-RDH142  
    2 SIMAP similar genes for NT5C1B using alignment to 4 protein entries:     5NT1B_HUMAN (see all proteins):
    NT5C1A    NT5C1B-RDH14

    Find genes that share paralogs with NT5C1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for NT5C1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2229780CNV Deletion18987734
    nsv2624CNV Insertion18451855
    nsv519085CNV Loss19592680
    esv2751837CNV Gain17911159

    Human Gene Mutation Database (HGMD): NT5C1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NT5C1B
    DNA2.0 Custom Variant and Variant Library Synthesis for NT5C1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610526    OMIM disorders: --

    1 disease for NT5C1B:    
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    infertility


    Find genes that share disorders with NT5C1B           About GenesLikeMe

    Genetic Association Database (GAD): NT5C1B
    Human Genome Epidemiology (HuGE) Navigator: NT5C1B (1 document)

    Export disorders for NT5C1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NT5C1B gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with NT5C1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (PubMed id 11690631)1, 2, 3 Sala-Newby G.B. and Newby A.C. (Biochim. Biophys. Acta 2001)
    2. Common genetic variation and performance on standardized cognitive tests. (PubMed id 20125193)1, 4 Cirulli E.T....Goldstein D.B. (Eur. J. Hum. Genet. 2010)
    3. Contribution of adenosine related genes to the risk of depression with disturbed sleep. (PubMed id 20392501)1, 4 Gass N....Paunio T. (J Affect Disord 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    6. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (EMBO J. 2013)
    7. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
    8. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. (PubMed id 17903304)4 Larson M.G....Levy D. (BMC Med. Genet. 2007)
    9. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (BMC Med. Genet. 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93034 HGNC: 17818 AceView: RDH14andNT5C1B Ensembl:ENSG00000185013 euGenes: HUgn93034
    ECgene: NT5C1B Kegg: 93034 H-InvDB: NT5C1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NT5C1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NT5C1B gene:
    Search GeneIP for patents involving NT5C1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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