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Aliases for NT5C1B Gene

Aliases for NT5C1B Gene

  • 5'-Nucleotidase, Cytosolic IB 2
  • 5-Nucleotidase, Cytosolic IB 2 3 5
  • Autoimmune Infertility-Related Protein 3 4
  • CN-IB 3 4
  • CN1B 3 4
  • AIRP 3 4
  • Testicular Tissue Protein Li 1 3
  • Cytosolic 5-Nucleotidase 1B 3
  • Cytosolic 5-Nucleotidase IB 4
  • EC 3.1.3.5 4

External Ids for NT5C1B Gene

Previous GeneCards Identifiers for NT5C1B Gene

  • GC02M018630
  • GC02M018711
  • GC02M018728
  • GC02M018657
  • GC02M018665
  • GC02M018599
  • GC02M018607
  • GC02M018744

Summaries for NT5C1B Gene

Entrez Gene Summary for NT5C1B Gene

  • Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NT5C1B Gene

NT5C1B (5'-Nucleotidase, Cytosolic IB) is a Protein Coding gene. Diseases associated with NT5C1B include Tracheal Cancer and Coenurosis. Among its related pathways are Metabolism and Nicotinate and nicotinamide metabolism. GO annotations related to this gene include nucleotide binding and 5-nucleotidase activity. An important paralog of this gene is NT5C1B-RDH14.

UniProtKB/Swiss-Prot for NT5C1B Gene

  • Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C1B Gene

Genomics for NT5C1B Gene

Regulatory Elements for NT5C1B Gene

Enhancers for NT5C1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F018479 1.5 ENCODE 10.2 +109.3 109327 1.1 ZFHX2 FEZF1 ZIC2 NT5C1B NT5C1B-RDH14 GC02M018508 LOC105373454
GH02F018625 0.7 FANTOM5 ENCODE 18.3 -37.0 -37006 2.0 JUND SIN3A NT5C1B NT5C1B-RDH14 RNU6-1215P OSR1 GC02M018608 GC02P018659
GH02F018520 1 Ensembl ENCODE 10.3 +68.9 68934 2.2 CTCF PKNOX1 TBL1XR1 ZBTB40 RAD21 HBP1 ZNF143 SMC3 FOS ZNF652 RNU6-1215P NT5C1B NT5C1B-RDH14 GC02M018508 ENSG00000260331
GH02F018800 1 ENCODE 10.1 -211.1 -211110 0.0 ATF1 MLX ARID4B DMAP1 ZNF48 SLC30A9 SP5 NFYC MXD4 MIER2 RNU6-1215P NT5C1B GC02P018799 GC02P018896
GH02F018788 1 Ensembl ENCODE 9.5 -199.4 -199385 1.0 SAP130 ZIC2 YY1 RERE HNF4G THAP11 GATAD2A NFIA TEAD1 MNT NT5C1B NT5C1B-RDH14 GC02P018799 GC02P018659
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NT5C1B on UCSC Golden Path with GeneCards custom track

Genomic Location for NT5C1B Gene

Chromosome:
2
Start:
18,562,871 bp from pter
End:
18,589,580 bp from pter
Size:
26,710 bases
Orientation:
Minus strand

Genomic View for NT5C1B Gene

Genes around NT5C1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5C1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5C1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5C1B Gene

Proteins for NT5C1B Gene

  • Protein details for NT5C1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96P26-5NT1B_HUMAN
    Recommended name:
    Cytosolic 5-nucleotidase 1B
    Protein Accession:
    Q96P26
    Secondary Accessions:
    • B5MCR0
    • B7ZVX7
    • Q53RX2
    • Q8N9W3
    • Q8NA26
    • Q96DU5
    • Q96KE6
    • Q96M25
    • Q96SA3

    Protein attributes for NT5C1B Gene

    Size:
    610 amino acids
    Molecular mass:
    68804 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK39108.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK83285.1; Type=Frameshift; Positions=320; Evidence={ECO:0000305}; Sequence=BAC04103.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC44363.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NT5C1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NT5C1B Gene

Post-translational modifications for NT5C1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NT5C1B Gene

Domains & Families for NT5C1B Gene

Gene Families for NT5C1B Gene

Protein Domains for NT5C1B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NT5C1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96P26

UniProtKB/Swiss-Prot:

5NT1B_HUMAN :
  • Belongs to the 5-nucleotidase type 3 family.
Family:
  • Belongs to the 5-nucleotidase type 3 family.
genes like me logo Genes that share domains with NT5C1B: view

Function for NT5C1B Gene

Molecular function for NT5C1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by ADP.
UniProtKB/Swiss-Prot Function:
Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

Enzyme Numbers (IUBMB) for NT5C1B Gene

Gene Ontology (GO) - Molecular Function for NT5C1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0008253 5-nucleotidase activity IEA,TAS --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with NT5C1B: view
genes like me logo Genes that share phenotypes with NT5C1B: view

Animal Model Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5C1B Gene

Localization for NT5C1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NT5C1B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NT5C1B gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for NT5C1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NT5C1B: view

Pathways & Interactions for NT5C1B Gene

genes like me logo Genes that share pathways with NT5C1B: view

Pathways by source for NT5C1B Gene

2 GeneGo (Thomson Reuters) pathways for NT5C1B Gene

Interacting Proteins for NT5C1B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352904%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q96P26-5NT1B_HUMAN ENSP00000352904 for NT5C1B Gene via IID STRING

Gene Ontology (GO) - Biological Process for NT5C1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006195 purine nucleotide catabolic process TAS --
GO:0009117 nucleotide metabolic process IEA --
GO:0016311 dephosphorylation IEA --
genes like me logo Genes that share ontologies with NT5C1B: view

No data available for SIGNOR curated interactions for NT5C1B Gene

Drugs & Compounds for NT5C1B Gene

(17) Drugs for NT5C1B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine Approved, Investigational Pharma Agonist 397
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
2'-Deoxyguanosine-5'-Monophosphate Experimental Pharma 0

(14) Additional Compounds for NT5C1B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-nicotinamide D-ribonucleotide
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
63-37-6
deoxyadenosine
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-b-D-Ribofuranose
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-beta-D-Ribofuranose
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-beta-delta-Ribofuranose
  • 2'-Deoxyadenosine
  • 2-Deoxyadenosine
958-09-8
Deoxyadenosine monophosphate
  • 2'-dAMP
  • 2'-Deoxy-5'-adenylate
  • 2'-Deoxy-5'-adenylic acid
  • 2'-Deoxy-Adenosine 5'-phosphorate
  • 2'-Deoxy-Adenosine 5'-phosphoric acid
653-63-4
deoxyguanosine
  • 2'-Deoxy-Guanosine
  • 2'-Deoxyguanosine
  • 2-Deoxyguanosine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)-Guanine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine
961-07-9
genes like me logo Genes that share compounds with NT5C1B: view

Transcripts for NT5C1B Gene

Unigene Clusters for NT5C1B Gene

5-nucleotidase, cytosolic IB:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NT5C1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: -
SP6:
SP7:

Relevant External Links for NT5C1B Gene

GeneLoc Exon Structure for
NT5C1B
ECgene alternative splicing isoforms for
NT5C1B

Expression for NT5C1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NT5C1B Gene

mRNA differential expression in normal tissues according to GTEx for NT5C1B Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for NT5C1B Gene

This gene is overexpressed in Serum (38.9) and Plasma (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NT5C1B Gene



Protein tissue co-expression partners for NT5C1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NT5C1B Gene:

NT5C1B

SOURCE GeneReport for Unigene cluster for NT5C1B Gene:

Hs.744358

mRNA Expression by UniProt/SwissProt for NT5C1B Gene:

Q96P26-5NT1B_HUMAN
Tissue specificity: Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liver and lung.
genes like me logo Genes that share expression patterns with NT5C1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NT5C1B Gene

Orthologs for NT5C1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for NT5C1B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia NT5C1B 34
  • 86.26 (n)
-- 35
  • 53 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NT5C1B 34
  • 81.67 (n)
-- 35
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nt5c1b 34 16 35
  • 77.42 (n)
rat
(Rattus norvegicus)
Mammalia Nt5c1b 34
  • 76.7 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 58 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 54 (a)
OneToMany
chicken
(Gallus gallus)
Aves NT5C1B 34
  • 75.08 (n)
-- 35
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5c1a 34
  • 68.73 (n)
zebrafish
(Danio rerio)
Actinopterygii nt5c1bb 34 35
  • 66.05 (n)
nt5c1ba 35
  • 59 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12354 34
Species where no ortholog for NT5C1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5C1B Gene

ENSEMBL:
Gene Tree for NT5C1B (if available)
TreeFam:
Gene Tree for NT5C1B (if available)

Paralogs for NT5C1B Gene

Paralogs for NT5C1B Gene

(2) SIMAP similar genes for NT5C1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NT5C1B: view

Variants for NT5C1B Gene

Sequence variations from dbSNP and Humsavar for NT5C1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10183289 -- 18,567,995(+) gtgaa(C/T)ttgaa intron-variant
rs11096544 -- 18,586,118(+) CAGAA(G/T)GGAGT intron-variant
rs111555888 -- 18,571,252(+) TCACA(C/G)TCAAC intron-variant
rs111562576 -- 18,586,185(+) GTAGA(A/G)AGCAT intron-variant
rs111730878 -- 18,583,196(+) ATGTT(C/G)ACAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NT5C1B Gene

Variant ID Type Subtype PubMed ID
nsv581114 CNV gain 21841781
nsv519085 CNV loss 19592680
nsv2624 CNV insertion 18451855
esv3589967 CNV loss 21293372
esv2751837 CNV gain 17911159
esv2229780 CNV deletion 18987734

Variation tolerance for NT5C1B Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NT5C1B Gene

Human Gene Mutation Database (HGMD)
NT5C1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NT5C1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5C1B Gene

Disorders for NT5C1B Gene

MalaCards: The human disease database

(11) MalaCards diseases for NT5C1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
tracheal cancer
  • ca trachea
coenurosis
  • coenuriasis
breast malignant phyllodes tumor
  • malignant cystosarcoma phyllodes
urogenital tuberculosis
  • genitourinary tuberculosis
ochronosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NT5C1B

Genetic Association Database (GAD)
NT5C1B
Human Genome Epidemiology (HuGE) Navigator
NT5C1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NT5C1B
genes like me logo Genes that share disorders with NT5C1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NT5C1B Gene

Publications for NT5C1B Gene

  1. Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (PMID: 11690631) Sala-Newby G.B. … Newby A.C. (Biochim. Biophys. Acta 2001) 2 3 4 64
  2. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3 46 64
  3. Contribution of adenosine related genes to the risk of depression with disturbed sleep. (PMID: 20392501) Gass N. … Paunio T. (J Affect Disord 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3 64

Products for NT5C1B Gene

Sources for NT5C1B Gene

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