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Aliases for NT5C1B Gene

Aliases for NT5C1B Gene

  • 5'-Nucleotidase, Cytosolic IB 2
  • CN1B 3 4 6
  • AIRP 3 4 6
  • Autoimmune Infertility-Related Protein 3 4
  • 5-Nucleotidase, Cytosolic IB 2 3
  • CN-IB 3 4
  • Cytosolic 5-Nucleotidase 1B 3
  • Cytosolic 5-Nucleotidase IB 4
  • EC 4

External Ids for NT5C1B Gene

Previous GeneCards Identifiers for NT5C1B Gene

  • GC02M018630
  • GC02M018711
  • GC02M018728
  • GC02M018657
  • GC02M018665
  • GC02M018599
  • GC02M018607
  • GC02M018744

Summaries for NT5C1B Gene

Entrez Gene Summary for NT5C1B Gene

  • Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NT5C1B Gene

NT5C1B (5'-Nucleotidase, Cytosolic IB) is a Protein Coding gene. Diseases associated with NT5C1B include infertility. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include nucleotide binding and 5-nucleotidase activity. An important paralog of this gene is NT5C1A.

UniProtKB/Swiss-Prot for NT5C1B Gene

  • Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C1B Gene

Genomics for NT5C1B Gene

Regulatory Elements for NT5C1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NT5C1B Gene

18,562,871 bp from pter
18,589,580 bp from pter
26,710 bases
Minus strand

Genomic View for NT5C1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NT5C1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5C1B Gene

Proteins for NT5C1B Gene

  • Protein details for NT5C1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytosolic 5-nucleotidase 1B
    Protein Accession:
    Secondary Accessions:
    • B5MCR0
    • B7ZVX7
    • Q53RX2
    • Q8N9W3
    • Q8NA26
    • Q96DU5
    • Q96KE6
    • Q96M25
    • Q96SA3

    Protein attributes for NT5C1B Gene

    610 amino acids
    Molecular mass:
    68804 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=AAK39108.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK83285.1; Type=Frameshift; Positions=320; Evidence={ECO:0000305}; Sequence=BAC04103.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC44363.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NT5C1B Gene


neXtProt entry for NT5C1B Gene

Proteomics data for NT5C1B Gene at MOPED

Post-translational modifications for NT5C1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NT5C1B Gene

No data available for DME Specific Peptides for NT5C1B Gene

Domains for NT5C1B Gene

Gene Families for NT5C1B Gene

Protein Domains for NT5C1B Gene


Suggested Antigen Peptide Sequences for NT5C1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 5-nucleotidase type 3 family.
  • Belongs to the 5-nucleotidase type 3 family.
genes like me logo Genes that share domains with NT5C1B: view

Function for NT5C1B Gene

Molecular function for NT5C1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by ADP.
UniProtKB/Swiss-Prot Function:
Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

Enzyme Numbers (IUBMB) for NT5C1B Gene

Gene Ontology (GO) - Molecular Function for NT5C1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0008253 5-nucleotidase activity IEA --
genes like me logo Genes that share ontologies with NT5C1B: view
genes like me logo Genes that share phenotypes with NT5C1B: view

Animal Model Products

miRNA for NT5C1B Gene

miRTarBase miRNAs that target NT5C1B

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NT5C1B Gene

Localization for NT5C1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NT5C1B Gene


Subcellular locations from

Jensen Localization Image for NT5C1B Gene COMPARTMENTS Subcellular localization image for NT5C1B gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for NT5C1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NT5C1B: view

Pathways for NT5C1B Gene

genes like me logo Genes that share pathways with NT5C1B: view

Pathways by source for NT5C1B Gene

2 GeneGo (Thomson Reuters) pathways for NT5C1B Gene

Interacting Proteins for NT5C1B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000352904 for NT5C1B Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NT5C1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006195 purine nucleotide catabolic process TAS --
GO:0009117 nucleotide metabolic process --
GO:0016311 dephosphorylation IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NT5C1B: view

Compounds for NT5C1B Gene

(28) HMDB Compounds for NT5C1B Gene

Compound Synonyms Cas Number PubMed IDs
2'-Deoxyguanosine 5'-monophosphate
  • 2'-Deoxy-5'-GMP
5-Thymidylic acid
  • 2'-Deoxythymidine 5'-monophosphate
  • 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
Adenosine monophosphate
  • 5'-AMP
  • 1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine
genes like me logo Genes that share compounds with NT5C1B: view

Transcripts for NT5C1B Gene

Unigene Clusters for NT5C1B Gene

5-nucleotidase, cytosolic IB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NT5C1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for NT5C1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5C1B Gene

mRNA expression in normal human tissues for NT5C1B Gene

mRNA differential expression in normal tissues according to GTEx for NT5C1B Gene

This gene is overexpressed in Testis (53.0).

Protein differential expression in normal tissues for NT5C1B Gene

This gene is overexpressed in Serum (38.9) and Plasma (27.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NT5C1B Gene

SOURCE GeneReport for Unigene cluster for NT5C1B Gene Hs.744358

mRNA Expression by UniProt/SwissProt for NT5C1B Gene

Tissue specificity: Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liver and lung.
genes like me logo Genes that share expressions with NT5C1B: view

Expression partners for NT5C1B Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NT5C1B Gene

Orthologs for NT5C1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for NT5C1B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NT5C1B 35
  • 81.67 (n)
  • 74.4 (a)
-- 36
  • 70 (a)
(Canis familiaris)
Mammalia NT5C1B 35
  • 86.26 (n)
  • 82.13 (a)
-- 36
  • 53 (a)
(Mus musculus)
Mammalia Nt5c1b 35
  • 77.42 (n)
  • 75.5 (a)
Nt5c1b 16
Nt5c1b 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Nt5c1b 35
  • 76.7 (n)
  • 74.55 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
(Gallus gallus)
Aves NT5C1B 35
  • 75.08 (n)
  • 76.62 (a)
-- 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5c1a 35
  • 68.73 (n)
  • 72.45 (a)
(Danio rerio)
Actinopterygii nt5c1bb 35
  • 66.05 (n)
  • 70.25 (a)
nt5c1ba 36
  • 59 (a)
nt5c1bb 36
  • 63 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12354 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for NT5C1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5C1B Gene

Gene Tree for NT5C1B (if available)
Gene Tree for NT5C1B (if available)

Paralogs for NT5C1B Gene

Paralogs for NT5C1B Gene

(2) SIMAP similar genes for NT5C1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NT5C1B: view

Variants for NT5C1B Gene

Structural Variations from Database of Genomic Variants (DGV) for NT5C1B Gene

Variant ID Type Subtype PubMed ID
esv2751837 CNV Gain 17911159
nsv2624 CNV Insertion 18451855
esv2229780 CNV Deletion 18987734
nsv519085 CNV Loss 19592680

Relevant External Links for NT5C1B Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for NT5C1B Gene

Disorders for NT5C1B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NT5C1B Gene in MalaCards »

(1) Disease for NT5C1B Gene

Relevant External Links for NT5C1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NT5C1B: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for NT5C1B Gene

Publications for NT5C1B Gene

  1. Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (PMID: 11690631) Sala-Newby G.B. … Newby A.C. (Biochim. Biophys. Acta 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3 48
  4. Contribution of adenosine related genes to the risk of depression with disturbed sleep. (PMID: 20392501) Gass N. … Paunio T. (J Affect Disord 2010) 3 48
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3

Products for NT5C1B Gene

Sources for NT5C1B Gene

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