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Aliases for NT5C1B Gene

Aliases for NT5C1B Gene

  • 5'-Nucleotidase, Cytosolic IB 2
  • 5-Nucleotidase, Cytosolic IB 2 3 5
  • Autoimmune Infertility-Related Protein 3 4
  • CN-IB 3 4
  • CN1B 3 4
  • AIRP 3 4
  • Testicular Tissue Protein Li 1 3
  • Cytosolic 5-Nucleotidase IB 4
  • EC 4

External Ids for NT5C1B Gene

Previous GeneCards Identifiers for NT5C1B Gene

  • GC02M018630
  • GC02M018711
  • GC02M018728
  • GC02M018657
  • GC02M018665
  • GC02M018599
  • GC02M018607
  • GC02M018744

Summaries for NT5C1B Gene

Entrez Gene Summary for NT5C1B Gene

  • Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologic processes (Sala-Newby and Newby, 2001 [PubMed 11690631]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NT5C1B Gene

NT5C1B (5'-Nucleotidase, Cytosolic IB) is a Protein Coding gene. Diseases associated with NT5C1B include Tracheal Cancer and Coenurosis. Among its related pathways are Purine metabolism and Metabolism. GO annotations related to this gene include nucleotide binding and 5-nucleotidase activity. An important paralog of this gene is NT5C1A.

UniProtKB/Swiss-Prot for NT5C1B Gene

  • Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C1B Gene

Genomics for NT5C1B Gene

Regulatory Elements for NT5C1B Gene

Enhancers for NT5C1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NT5C1B on UCSC Golden Path with GeneCards custom track

Genomic Location for NT5C1B Gene

18,562,871 bp from pter
18,589,580 bp from pter
26,710 bases
Minus strand

Genomic View for NT5C1B Gene

Genes around NT5C1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5C1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5C1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5C1B Gene

Proteins for NT5C1B Gene

  • Protein details for NT5C1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytosolic 5-nucleotidase 1B
    Protein Accession:
    Secondary Accessions:
    • B5MCR0
    • B7ZVX7
    • Q53RX2
    • Q8N9W3
    • Q8NA26
    • Q96DU5
    • Q96KE6
    • Q96M25
    • Q96SA3

    Protein attributes for NT5C1B Gene

    610 amino acids
    Molecular mass:
    68804 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available
    • Sequence=AAK39108.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK83285.1; Type=Frameshift; Positions=320; Evidence={ECO:0000305}; Sequence=BAC04103.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC44363.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NT5C1B Gene


neXtProt entry for NT5C1B Gene

Proteomics data for NT5C1B Gene at MOPED

Post-translational modifications for NT5C1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for NT5C1B

No data available for DME Specific Peptides for NT5C1B Gene

Domains & Families for NT5C1B Gene

Gene Families for NT5C1B Gene

Protein Domains for NT5C1B Gene


Suggested Antigen Peptide Sequences for NT5C1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 5-nucleotidase type 3 family.
  • Belongs to the 5-nucleotidase type 3 family.
genes like me logo Genes that share domains with NT5C1B: view

Function for NT5C1B Gene

Molecular function for NT5C1B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by ADP.
UniProtKB/Swiss-Prot Function:
Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

Enzyme Numbers (IUBMB) for NT5C1B Gene

genes like me logo Genes that share phenotypes with NT5C1B: view

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5C1B Gene

Localization for NT5C1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for NT5C1B Gene


Subcellular locations from

Jensen Localization Image for NT5C1B Gene COMPARTMENTS Subcellular localization image for NT5C1B gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for NT5C1B Gene

Pathways & Interactions for NT5C1B Gene

genes like me logo Genes that share pathways with NT5C1B: view

Pathways by source for NT5C1B Gene

2 GeneGo (Thomson Reuters) pathways for NT5C1B Gene

Interacting Proteins for NT5C1B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000352904 for NT5C1B Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for NT5C1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process TAS --
GO:0055086 nucleobase-containing small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with NT5C1B: view

No data available for SIGNOR curated interactions for NT5C1B Gene

Drugs & Compounds for NT5C1B Gene

(15) Drugs for NT5C1B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine Approved, Investigational Pharma Agonist 384
Adenosine monophosphate Approved Nutra 0
2'-Deoxyguanosine-5'-Monophosphate Experimental Pharma 0
5-Thymidylic acid Experimental Pharma 0
Cytidine Experimental Pharma 0

(16) Additional Compounds for NT5C1B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-nicotinamide D-ribonucleotide
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-b-D-Ribofuranose
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-beta-D-Ribofuranose
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-beta-delta-Ribofuranose
  • 2'-Deoxyadenosine
  • 2-Deoxyadenosine
Deoxyadenosine monophosphate
  • 2'-dAMP
  • 2'-Deoxy-5'-adenylate
  • 2'-Deoxy-5'-adenylic acid
  • 2'-Deoxy-Adenosine 5'-phosphorate
  • 2'-Deoxy-Adenosine 5'-phosphoric acid
  • 2'-Deoxy-Guanosine
  • 2'-Deoxyguanosine
  • 2-Deoxyguanosine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)-Guanine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine
genes like me logo Genes that share compounds with NT5C1B: view

Transcripts for NT5C1B Gene

Unigene Clusters for NT5C1B Gene

5-nucleotidase, cytosolic IB:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NT5C1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for NT5C1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5C1B Gene

mRNA expression in normal human tissues for NT5C1B Gene

mRNA differential expression in normal tissues according to GTEx for NT5C1B Gene

This gene is overexpressed in Testis (x53.0).

Protein differential expression in normal tissues from HIPED for NT5C1B Gene

This gene is overexpressed in Serum (38.9) and Plasma (27.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NT5C1B Gene

SOURCE GeneReport for Unigene cluster for NT5C1B Gene Hs.744358

mRNA Expression by UniProt/SwissProt for NT5C1B Gene

Tissue specificity: Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liver and lung.
genes like me logo Genes that share expression patterns with NT5C1B: view

Protein tissue co-expression partners for NT5C1B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NT5C1B Gene

Orthologs for NT5C1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for NT5C1B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NT5C1B 35
  • 81.67 (n)
  • 74.4 (a)
-- 36
  • 70 (a)
(Canis familiaris)
Mammalia NT5C1B 35
  • 86.26 (n)
  • 82.13 (a)
-- 36
  • 53 (a)
(Mus musculus)
Mammalia Nt5c1b 35
  • 77.42 (n)
  • 75.5 (a)
Nt5c1b 16
Nt5c1b 36
  • 72 (a)
(Rattus norvegicus)
Mammalia Nt5c1b 35
  • 76.7 (n)
  • 74.55 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 58 (a)
(Gallus gallus)
Aves NT5C1B 35
  • 75.08 (n)
  • 76.62 (a)
-- 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nt5c1a 35
  • 68.73 (n)
  • 72.45 (a)
(Danio rerio)
Actinopterygii nt5c1bb 35
  • 66.05 (n)
  • 70.25 (a)
nt5c1ba 36
  • 59 (a)
nt5c1bb 36
  • 63 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12354 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
Species with no ortholog for NT5C1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5C1B Gene

Gene Tree for NT5C1B (if available)
Gene Tree for NT5C1B (if available)

Paralogs for NT5C1B Gene

Paralogs for NT5C1B Gene

(2) SIMAP similar genes for NT5C1B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NT5C1B: view

Variants for NT5C1B Gene

Structural Variations from Database of Genomic Variants (DGV) for NT5C1B Gene

Variant ID Type Subtype PubMed ID
esv2751837 CNV Gain 17911159
nsv2624 CNV Insertion 18451855
esv2229780 CNV Deletion 18987734
nsv519085 CNV Loss 19592680

Variation tolerance for NT5C1B Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NT5C1B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for NT5C1B Gene

Disorders for NT5C1B Gene

MalaCards: The human disease database

(12) MalaCards diseases for NT5C1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
tracheal cancer
  • ca trachea
  • coenuriasis
urogenital tuberculosis
  • genitourinary tuberculosis
intravenous leiomyomatosis
  • leiomyomatosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for NT5C1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NT5C1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NT5C1B Gene

Publications for NT5C1B Gene

  1. Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (PMID: 11690631) Sala-Newby G.B. … Newby A.C. (Biochim. Biophys. Acta 2001) 2 3 4 67
  2. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? (PMID: 23314748) Nathan J.A. … Goldberg A.L. (EMBO J. 2013) 3
  3. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3
  4. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  5. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3

Products for NT5C1B Gene

Sources for NT5C1B Gene