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Aliases for NT5C1A Gene

Aliases for NT5C1A Gene

  • 5'-Nucleotidase, Cytosolic IA 2
  • Cytosolic 5-Nucleotidase IA 2 3 4
  • CN1A 3 4 6
  • 5-Nucleotidase, Cytosolic IA 2 3
  • AMP-Specific 5-NT 2 3
  • CN-IA 3 4
  • CN-I 3 4
  • CN1 3 6
  • CNI 3 6
  • Cytosolic 5 Nucleotidase, Type 1A 3
  • Cytosolic 5-Nucleotidase 1A 3
  • Cytosolic 5 Nucleotidase 2
  • EC 4
  • Type 1A 2

External Ids for NT5C1A Gene

Previous GeneCards Identifiers for NT5C1A Gene

  • GC01M040154
  • GC01M039128
  • GC01M039588
  • GC01M039538
  • GC01M039793
  • GC01M039897
  • GC01M038243

Summaries for NT5C1A Gene

Entrez Gene Summary for NT5C1A Gene

  • Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NT5C1A Gene

NT5C1A (5'-Nucleotidase, Cytosolic IA) is a Protein Coding gene. Among its related pathways are Integrated Pancreatic Cancer Pathway and Metabolism. GO annotations related to this gene include nucleotide binding and 5-nucleotidase activity. An important paralog of this gene is NT5C1B.

UniProtKB/Swiss-Prot for NT5C1A Gene

  • Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C1A Gene

Genomics for NT5C1A Gene

Regulatory Elements for NT5C1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NT5C1A Gene

39,659,121 bp from pter
39,672,038 bp from pter
12,918 bases
Minus strand

Genomic View for NT5C1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NT5C1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5C1A Gene

Proteins for NT5C1A Gene

  • Protein details for NT5C1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytosolic 5-nucleotidase 1A
    Protein Accession:
    Secondary Accessions:
    • Q3SYB9
    • Q5TG98
    • Q9BWT8

    Protein attributes for NT5C1A Gene

    368 amino acids
    Molecular mass:
    41021 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NT5C1A Gene

Proteomics data for NT5C1A Gene at MOPED

Post-translational modifications for NT5C1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NT5C1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NT5C1A Gene

Domains for NT5C1A Gene

Gene Families for NT5C1A Gene

Protein Domains for NT5C1A Gene


Suggested Antigen Peptide Sequences for NT5C1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BXI3
  • Belongs to the 5-nucleotidase type 3 family.
genes like me logo Genes that share domains with NT5C1A: view

Function for NT5C1A Gene

Molecular function for NT5C1A Gene

UniProtKB/Swiss-Prot CatalyticActivity: A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by ADP
UniProtKB/Swiss-Prot Function: Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.

Enzyme Numbers (IUBMB) for NT5C1A Gene

Gene Ontology (GO) - Molecular Function for NT5C1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IEA --
GO:0008253 5-nucleotidase activity NAS 11133996
genes like me logo Genes that share ontologies with NT5C1A: view

Animal Model Products

CRISPR Products

miRNA for NT5C1A Gene

miRTarBase miRNAs that target NT5C1A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NT5C1A

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NT5C1A Gene

Localization for NT5C1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for NT5C1A Gene


Subcellular locations from

Jensen Localization Image for NT5C1A Gene COMPARTMENTS Subcellular localization image for NT5C1A gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for NT5C1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NT5C1A: view

Pathways for NT5C1A Gene

genes like me logo Genes that share pathways with NT5C1A: view

Interacting Proteins for NT5C1A Gene

Gene Ontology (GO) - Biological Process for NT5C1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006195 purine nucleotide catabolic process TAS --
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0009116 nucleoside metabolic process NAS 11133996
GO:0009117 nucleotide metabolic process --
genes like me logo Genes that share ontologies with NT5C1A: view

Compounds for NT5C1A Gene

(28) HMDB Compounds for NT5C1A Gene

Compound Synonyms Cas Number PubMed IDs
2'-Deoxyguanosine 5'-monophosphate
  • 2'-Deoxy-5'-GMP
5-Thymidylic acid
  • 2'-Deoxythymidine 5'-monophosphate
  • 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
Adenosine monophosphate
  • 5'-AMP
  • 1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine

(1) Novoseek inferred chemical compound relationships for NT5C1A Gene

Compound -log(P) Hits PubMed IDs
nucleoside 50.4 2
genes like me logo Genes that share compounds with NT5C1A: view

Transcripts for NT5C1A Gene

mRNA/cDNA for NT5C1A Gene

(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NT5C1A Gene

5-nucleotidase, cytosolic IA:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NT5C1A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NT5C1A Gene

No ASD Table

Relevant External Links for NT5C1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5C1A Gene

mRNA expression in normal human tissues for NT5C1A Gene

mRNA differential expression in normal tissues according to GTEx for NT5C1A Gene

This gene is overexpressed in Muscle - Skeletal (16.7), Heart - Left Ventricle (6.0), Heart - Atrial Appendage (6.0), and Brain - Cerebellar Hemisphere (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NT5C1A Gene

SOURCE GeneReport for Unigene cluster for NT5C1A Gene Hs.307006

mRNA Expression by UniProt/SwissProt for NT5C1A Gene

Tissue specificity: Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.
genes like me logo Genes that share expressions with NT5C1A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NT5C1A Gene

Orthologs for NT5C1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for NT5C1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NT5C1A 35
  • 99.28 (n)
  • 99.73 (a)
NT5C1A 36
  • 100 (a)
(Bos Taurus)
Mammalia NT5C1A 35
  • 91.23 (n)
  • 95.89 (a)
NT5C1A 36
  • 95 (a)
(Canis familiaris)
Mammalia NT5C1A 35
  • 91.3 (n)
  • 95.88 (a)
NT5C1A 36
  • 94 (a)
(Mus musculus)
Mammalia Nt5c1a 35
  • 89.22 (n)
  • 95.62 (a)
Nt5c1a 16
Nt5c1a 36
  • 94 (a)
(Monodelphis domestica)
Mammalia NT5C1A 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia NT5C1A 36
  • 90 (a)
(Rattus norvegicus)
Mammalia Nt5c1a 35
  • 87.63 (n)
  • 95.01 (a)
(Gallus gallus)
Aves NT5C1A 35
  • 80.35 (n)
  • 86.42 (a)
NT5C1A 36
  • 83 (a)
(Anolis carolinensis)
Reptilia NT5C1A 36
  • 79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8799 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495335 35
  • 71.48 (n)
  • 80.45 (a)
MGC75654 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5436 35
(Danio rerio)
Actinopterygii LOC799449 35
  • 72.02 (n)
  • 81.97 (a)
nt5c1a 36
  • 66 (a)
NT5C1A (2 of 2) 36
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
Species with no ortholog for NT5C1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5C1A Gene

Gene Tree for NT5C1A (if available)
Gene Tree for NT5C1A (if available)

Paralogs for NT5C1A Gene

Paralogs for NT5C1A Gene

Selected SIMAP similar genes for NT5C1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NT5C1A: view

Variants for NT5C1A Gene

Sequence variations from dbSNP and Humsavar for NT5C1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs734497 -- 39,665,417(+) TTGGG(G/T)TTCTG intron-variant
rs752667 -- 39,666,266(+) TGTCA(C/T)TCAGA intron-variant
rs784594 -- 39,665,509(+) CTCAT(G/T)CTCAT intron-variant
rs784595 -- 39,669,345(+) ATTCC(C/T)AGTAG intron-variant
rs784596 -- 39,669,918(+) TGAAA(A/G)ATCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NT5C1A Gene

Variant ID Type Subtype PubMed ID
nsv7177 OTHER Inversion 18451855
nsv577 CNV Insertion 18451855
esv2530832 CNV Insertion 19546169

Relevant External Links for NT5C1A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5C1A Gene

Disorders for NT5C1A Gene

(1) University of Copenhagen DISEASES for NT5C1A Gene

Relevant External Links for NT5C1A

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with NT5C1A: view

No data available for UniProtKB/Swiss-Prot for NT5C1A Gene

Publications for NT5C1A Gene

  1. Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance. (PMID: 11133996) Hunsucker S.A. … Mitchell B.S. (J. Biol. Chem. 2001) 2 3 4 23
  2. Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (PMID: 11690631) Sala-Newby G.B. … Newby A.C. (Biochim. Biophys. Acta 2001) 2 3 23
  3. Expression of cytosolic 5' nucleotidase does not correlate with expression of oxidative metabolism marker: myoglobine in human skeletal muscles. (PMID: 19352542) Lechward K. … Tkacz-Stachowska K. (Acta Biochim. Biophys. Sin. (Shanghai) 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for NT5C1A Gene

Sources for NT5C1A Gene

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