NT5C1A Gene
protein-coding GIFtS: 55
GCID: GC01M040154
|
|
5'-nucleotidase, cytosolic IA
| |
Aliases for NT5C1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| 5'-Nucleotidase, Cytosolic IA1 2 | | AMP-Specific 5'-NT2 | | CN-I1 2 | | Cytosolic 5' Nucleotidase, Type 1A2 | | CN-IA1 2 | | Cytosolic 5'-Nucleotidase 1A2 | | CN11 2 | | EC 3.1.3.53 | | CN1A1 2 | | CN-I1 2 | | Cytosolic 5'-Nucleotidase IA2 3 | | CN-IA1 2 | | MGC1191991 | | CN1A1 2 | | MGC1192011 | | |
Export aliases for NT5C1A gene to outside databasesPrevious GC identifers: GC01M039128 GC01M039588 GC01M039538 GC01M039793 GC01M039897 GC01M038243 |
Summaries for NT5C1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for NT5C1A: Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 (PubMed11133996)).(supplied by OMIM, Mar 2008) UniProtKB/Swiss-Prot: 5NT1A_HUMAN, Q9BXI3Function: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity.Helps to regulate adenosine levels in heart during ischemia and hypoxia
|
Genomic Views for NT5C1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NT5C1A gene promoter: POU2F2 (Oct-2.1) Oct-B1 oct-B3 Sp1 oct-B2 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B Other transcription factors
Search SABiosciences Chromatin IP Primers for NT5C1A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NT5C1A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.3-p33 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.3-p33NT5C1A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M040154: view genomic region
(about GC identifiers)
Start:
|
40,124,793 bp from pter |
End:
|
40,137,710 bp from pter |
Size:
|
12,918 bases |
Orientation:
|
minus strand |
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Proteins for NT5C1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: 5NT1A_HUMAN, Q9BXI3 (See
protein sequence)Recommended Name: Cytosolic 5'-nucleotidase 1A Size: 368 amino acids; 41021 Da
Cofactor: Magnesium
Subcellular location: Cytoplasm
Secondary accessions: Q3SYB9 Q5TG98 Q9BWT8Explore the universe of human proteins at neXtProt for NT5C1A: NX_Q9BXI3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BXI3 NT5C1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115915.1 ENSEMBL proteins: ENSP00000235628 Reactome Protein details: Q9BXI3 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
NT5C1A for ontologies About GeneDecksing
NT5C1A Antibody Products: Assay Products for NT5C1A: |
Protein
Domains / Families for NT5C1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NT5C1A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BXI3ProtoNet protein and cluster: Q9BXI3 1 Blocks protein family: IPB010394 5-nucleotidase
UniProtKB/Swiss-Prot: 5NT1A_HUMAN, Q9BXI3Similarity: Belongs to the 5'-nucleotidase type 3 family |
Function for NT5C1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: 5NT1A_HUMAN, Q9BXI3Function: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity.Helps to regulate adenosine levels in heart during ischemia and hypoxiaCatalytic activity: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphateEnzyme regulation: Activated by ADPEnzyme Number (IUBMB): EC 3.1.3.51
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NT5C1A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NT5C1A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5C1A |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
NT5C1A for ontologies About GeneDecksing
|
Pathways & Interactions for NT5C1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Purine metabolism | | | 2 | NAD metabolism | | | 3 | Pyrimidine metabolism | | | 4 | Metabolism | | | 5 | ATP/ITP metabolism | |
Pathway sources See GeneCards unified pathways Show all pathways
2 EMD Millipore Pathways for NT5C1A
2 GeneGo (Thomson Reuters) Pathways for NT5C1A 4 BioSystems Pathways for NT5C1A 
5/6
Reactome Pathways for NT5C1A (see all 6)
4
Kegg Pathways (Kegg details for NT5C1A):
NT5C1A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NT5C1A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/77 Interacting proteins for NT5C1A (ENSP000002356284) via UniProtKB, MINT, STRING, and/or I2D (see all 77)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006144 | purine nucleobase metabolic process |
TAS | -- | | GO:0006195 | purine nucleotide catabolic process |
TAS | -- | | GO:0006206 | pyrimidine nucleobase metabolic process |
TAS | -- | | GO:0009116 | nucleoside metabolic process |
NAS | 11133996 | | GO:0009128 | purine nucleoside monophosphate catabolic process |
IEA | -- |
NT5C1A for ontologies About GeneDecksing
|
Drugs & Compounds for NT5C1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
NT5C1A for compounds About GeneDecksing
Browse Tocris compounds for NT5C1A
10/28 HMDB Compounds for NT5C1A (see all 28) About this table 1 Novoseek chemical compound relationship for NT5C1A gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| nucleoside |
50.4 |
2 |
11133996 (2) |
Search CenterWatch for drugs/clinical trials and news about NT5C1A / 5NT1A 
|
Transcripts for NT5C1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for NT5C1A gene: NM_032526.1 Unigene Cluster for NT5C1A: 5'-nucleotidase, cytosolic IA Hs.307006 [show with all ESTs]Unigene Representative Sequence: BC1038791 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000235628(uc001cdq.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NT5C1A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NT5C1A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: NT5C1A (NM_032526) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for NT5C1A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NT5C1A  |
Additional cDNA sequence: AF331801.1 AY028778.1 BC103879.1 BC103880.1 1 DOTS entry: DT.91803821 5 AceView cDNA sequences: AY028778 AF331801 NM_032526 CD634073 CD634072 GeneLoc Exon Structure
|
Expression for NT5C1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| NT5C1A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TGCCTTATGG
About this image See NT5C1A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for NT5C1A
SOURCE GeneReport for Unigene cluster: Hs.307006 UniProtKB/Swiss-Prot: 5NT1A_HUMAN, Q9BXI3Tissue specificity: Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney andpancreas SABiosciences Custom PCR Arrays for NT5C1A
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NT5C1A Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NT5C1A | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NT5C1A | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NT5C1A | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5C1A |
Orthologs for NT5C1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for NT5C1A gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Nt5c1a1 , 5 |
5'-nucleotidase, cytosolic IA1, 5 |
89.22(n)1 95.62(a)1 |
  |
4 (57.40 cM)5 2307181 NM_001085502.11 NP_001078971.11 1232015045 |
chicken (Gallus gallus) |
Aves |
NT5C1A1 |
5'-nucleotidase, cytosolic IA |
79.58(n) 85.19(a) |
  |
419675 XM_417822.3 XP_417822.2 |
lizard (Anolis carolinensis) |
Reptilia |
NT5C1A6 |
-- |
82(a) |
1 ↔ 1 |
GL343481.1(207875-221710) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.87992 |
Xenopus laevis transcribed sequence with moderate similarity more |
83.1(n) |
  |
BJ066298.1 |
zebrafish (Danio rerio) |
Actinopterygii |
570917492 |
-- |
74.47(n) |
  |
57091749 |
ENSEMBL Gene Tree for NT5C1A (if available) TreeFam Gene Tree for NT5C1A (if available)  |
Paralogs for NT5C1A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for NT5C1A gene
- NT5C1B-RDH142 NT5C1B2
2 SIMAP similar genes for NT5C1A using alignment to 1 protein entry: 5NT1A_HUMAN:NT5C1B NT5C1B-RDH14
NT5C1A for paralogs About GeneDecksing
|
Genomic Variants for NT5C1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for NT5C1A (40124793 - 40137710 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for NT5C1A 1 Indel: 97337  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NT5C1A |
|
Disorders
/ Diseases for NT5C1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NT5C1A for disorders About GeneDecksing
OMIM gene information: 610525
OMIM disorders: --
6 diseases for NT5C1A: About MalaCardscrigler-najjar syndrome amyotrophic lateral sclerosis lateral sclerosis infertility ischemia hypoxia 1 disease from the University of Copenhagen DISEASES database for NT5C1A:Bilirubin metabolic disorder Export disorders for NT5C1A gene to outside databases
|
Publications for NT5C1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for NT5C1A gene, integrated from 9 sources (see all 12): (articles sorted by number of sources associating them with NT5C1A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance. (PubMed id 11133996)1, 2, 3, 9 Hunsucker S.A.... Mitchell B.S. (2001)
- Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (PubMed id 11690631)1, 3, 9 Sala-Newby G.B. and Newby A.C. (2001)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of cytosolic 5' nucleotidase does not correlate with expression of oxidative metabolism marker: myoglobine in human skeletal muscles. (PubMed id 19352542)1, 9 Lechward K. and Tkacz-Stachowska K. (2009)
- Suppression of 5'-nucleotidase enzymes promotes AMP-a ctivated protein kinase (AMPK) phosphorylation and metabolism in human and mous e skeletal muscle. (PubMed id 21873433)1 Kulkarni S.S....Zierath J.R. (2011)
- Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PubMed id 19451621)1 Landers J.E....Brown R.H. (2009)
- Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I activity in MOLT-4 cells. (PubMed id 17065091)1 Fyrberg A....Lotfi K. (2006)
- Expression of human ecto-5'-nucleotidase in pig endothelium increases adenosine production and protects from NK cell-mediated lysis. (PubMed id 15888028)1 Osborne F.N....Smolenski R.T. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for NT5C1A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing NT5C1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NT5C1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NT5C1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for NT5C1A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for NT5C1A gene: Search GeneIP for patents involving NT5C1A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for NT5C1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | NT5C1A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NT5C1A |
|  |  |  | | | ThermoFisher Antibodies for NT5C1A |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NT5C1A |
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