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NT5C1A Gene

protein-coding   GIFtS: 56
GCID: GC01M040154

5'-Nucleotidase, Cytosolic IA

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
5'-Nucleotidase, Cytosolic IA1 2     CN-I2
Cytosolic 5'-Nucleotidase IA1 2 3     CN-IA2
AMP-Specific 5'-NT1 2     Cytosolic 5' Nucleotidase, Type 1A2
CN12 5     Cytosolic 5'-Nucleotidase 1A2
CN1A2 5     EC 3.1.3.53
CNI2 5     cN-I3
Cytosolic 5' Nucleotidase1     cN-IA3
Type 1A1     cN1A3

External Ids:    HGNC: 178191   Entrez Gene: 846182   Ensembl: ENSG000001169817   OMIM: 6105255   UniProtKB: Q9BXI33   

Export aliases for NT5C1A gene to outside databases

Previous GC identifers: GC01M039128 GC01M039588 GC01M039538 GC01M039793 GC01M039897 GC01M038243


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for NT5C1A Gene:
Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 (PubMed
11133996)).(supplied by OMIM, Mar 2008)

GeneCards Summary for NT5C1A Gene:
NT5C1A (5'-nucleotidase, cytosolic IA) is a protein-coding gene. Diseases associated with NT5C1A include crigler-najjar syndrome, and bilirubin metabolic disorder. GO annotations related to this gene include 5'-nucleotidase activity and nucleotide binding. An important paralog of this gene is NT5C1B-RDH14.

UniProtKB/Swiss-Prot: 5NT1A_HUMAN, Q9BXI3
Function: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate
specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the NT5C1A gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   Sp1   oct-B2   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNT5C1A promoter sequence
   Search Chromatin IP Primers for NT5C1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NT5C1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3-p33   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.3-p33

NT5C1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NT5C1A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M040154:  view genomic region     (about GC identifiers)

Start:
40,124,793 bp from pter      End:
40,137,710 bp from pter
Size:
12,918 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: 5NT1A_HUMAN, Q9BXI3 (See protein sequence)
Recommended Name: Cytosolic 5'-nucleotidase 1A  
Size: 368 amino acids; 41021 Da
Cofactor: Magnesium
Secondary accessions: Q3SYB9 Q5TG98 Q9BWT8

Explore the universe of human proteins at neXtProt for NT5C1A: NX_Q9BXI3

Explore proteomics data for NT5C1A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See NT5C1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115915.1  
    ENSEMBL proteins: 
     ENSP00000235628  
    Reactome Protein details: Q9BXI3

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: 5a-nucleotidase IA
    Adenosine turnover

    1 InterPro protein domain:
     IPR010394 5-nucleotidase

    Graphical View of Domain Structure for InterPro Entry Q9BXI3

    ProtoNet protein and cluster: Q9BXI3

    1 Blocks protein domain: IPB010394 5-nucleotidase

    UniProtKB/Swiss-Prot: 5NT1A_HUMAN, Q9BXI3
    Similarity: Belongs to the 5'-nucleotidase type 3 family


    NT5C1A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: 5NT1A_HUMAN, Q9BXI3
    Function: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate
    specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia
    Catalytic activity: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate
    Enzyme regulation: Activated by ADP

         Enzyme Number (IUBMB): EC 3.1.3.51

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0000287magnesium ion binding IEA--
    GO:00082535'-nucleotidase activity NAS11133996
         
    NT5C1A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NT5C1A
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    miRNA
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    miRTarBase miRNAs that target NT5C1A:
    hsa-mir-335-5p (MIRT018598)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    5NT1A_HUMAN, Q9BXI3: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    mitochondrion2
    nucleus2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    NT5C1A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for NT5C1A About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (REACTOME)
    Purine metabolism0.42
    Purine catabolism0.00
    Metabolism of nucleotides0.42
    adenosine nucleotides degradation0.00
    purine nucleotides degradation0.00
    2Purine metabolism (KEGG)
    Purine metabolism0.38
    ATP ITP metabolism0.31
    Pyrimidine metabolism0.38
    3Nicotinate and nicotinamide metabolism
    Nicotinate and nicotinamide metabolism0.43
    NAD metabolism0.43
    4Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    5Pyrimidine metabolism
    Pyrimidine metabolism0.33
    Pyrimidine catabolism0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 GeneGo (Thomson Reuters) Pathways for NT5C1A
        NAD metabolism
    ATP/ITP metabolism

    3 BioSystems Pathways for NT5C1A
        Integrated Pancreatic Cancer Pathway
    adenosine nucleotides degradation
    purine nucleotides degradation


    2 Reactome Pathways for NT5C1A
        Pyrimidine catabolism
    Purine catabolism


    4 Kegg Pathways  (Kegg details for NT5C1A):
        Purine metabolism
    Pyrimidine metabolism
    Nicotinate and nicotinamide metabolism
    Metabolic pathways


    NT5C1A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NT5C1A
    Interactions:

        Search GeneGlobe Interaction Network for NT5C1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NT5C1A (ENSP000002356284) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADAENSP000003619654STRING: ENSP00000361965
    ADKENSP000002866214STRING: ENSP00000286621
    ADSSENSP000003554934STRING: ENSP00000355493
    AMPD1ENSP000003165204STRING: ENSP00000316520
    AMPD2ENSP000002565784STRING: ENSP00000256578
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006144purine nucleobase metabolic process TAS--
    GO:0006195purine nucleotide catabolic process TAS--
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0009116nucleoside metabolic process NAS11133996
    GO:0009117nucleotide metabolic process ----

    NT5C1A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NT5C1A (5NT1A)

    Selected HMDB Compounds for NT5C1A (see all 28)    About this table
    CompoundSynonyms CAS #PubMed Ids
    2'-Deoxyguanosine 5'-monophosphate2'-Deoxy-5'-GMP (see all 21)902-04-5--
    5-Thymidylic acid2'-Deoxythymidine 5'-monophosphate (see all 28)365-07-1--
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    Deoxyadenosine1-(6-amino-9H-purin-9-yl)-1,2-dideoxy-b-D-Ribofuranose (see all 22)958-09-8--
    Deoxyadenosine monophosphate2'-Deoxy-5'-adenylate (see all 24)653-63-4--
    Deoxycytidine1-(2-Deoxy-b-D-ribofuranosyl)cytosine (see all 15)951-77-9--
    Deoxyguanosine2'-Deoxyguanosine (see all 11)961-07-9--

    1 Novoseek inferred chemical compound relationship for NT5C1A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nucleoside 50.4 2 11133996 (2)



    NT5C1A for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NT5C1A gene: 
    NM_032526.1  

    Unigene Cluster for NT5C1A:

    5'-nucleotidase, cytosolic IA
    Hs.307006  [show with all ESTs]
    Unigene Representative Sequence: BC103879
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000235628(uc001cdq.1)
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat NT5C1A
      QuantiFast Probe-based Assays in human, mouse, rat NT5C1A

    Additional mRNA sequence: 

    AF331801.1 AY028778.1 BC103879.1 BC103880.1 

    1 DOTS entry:

    DT.91803821 

    5 AceView cDNA sequences:

    NM_032526 AF331801 AY028778 CD634073 CD634072 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NT5C1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCTTATGG
    NT5C1A Expression
    About this image

    NT5C1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NT5C1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.307006

    UniProtKB/Swiss-Prot: 5NT1A_HUMAN, Q9BXI3
    Tissue specificity: Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney
    and pancreas

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NT5C1A gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nt5c1a1 , 5 5'-nucleotidase, cytosolic IA1, 5 89.22(n)1
    95.62(a)1
      4 (57.40 cM)5
    2307181  NM_001085502.11  NP_001078971.11 
     1232015045 
    chicken
    (Gallus gallus)
    Aves NT5C1A1 5'-nucleotidase, cytosolic IA 80.35(n)
    86.42(a)
      419675  XM_417822.4  XP_417822.3 
    lizard
    (Anolis carolinensis)
    Reptilia NT5C1A6
    5'-nucleotidase, cytosolic IA
    79(a)
    1 ↔ 1
    GL343481.1(207438-221710)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.87992 Xenopus laevis transcribed sequence with moderate similarity more 83.1(n)    BJ066298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570917492   -- 74.47(n)    57091749 


    ENSEMBL Gene Tree for NT5C1A (if available)
    TreeFam Gene Tree for NT5C1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for NT5C1A gene
    NT5C1B-RDH142  NT5C1B2  
    2 SIMAP similar genes for NT5C1A using alignment to 1 protein entry:     5NT1A_HUMAN:
    NT5C1B    NT5C1B-RDH14

    NT5C1A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NT5C1A (see all 326)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1113729891,2
    F--40124409(+) GGACAG/TAGCTT 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1817105361,2
    --40124483(+) CTAAGC/TCACTA 1 -- ds50010--------
    rs1401416171,2
    --40124566(+) TGCACA/TGTCCT 1 -- ds50010--------
    rs1420064221,2
    --40124657(+) CTACAA/GGTACA 1 -- ds50010--------
    rs1435733201,2
    C--40124729(+) TACCA-/GAGGAGGT 1 -- ds50010--------
    rs1124212791,2
    C,F--40124804(+) TGCAGA/CTGGGG 2 A S mis12Minor allele frequency- C:0.01CSA NA 4554
    rs1456468431,2
    C,F--40124934(+) TGTGGG/ACGGAT 2 /R syn11Minor allele frequency- A:0.00NA 4546
    rs1903444711,2
    C--40124935(+) GTGGGC/TGGATC 2 H R mis11Minor allele frequency- T:0.00EU 1207
    rs2003577101,2
    C--40125035(+) GGCCCC/TGGAAC 2 R G mis10--------
    rs412645071,2
    C--40125053(+) ACTGCA/GTGCTG 2 R C mis10--------

    HapMap Linkage Disequilibrium report for NT5C1A (40124793 - 40137710 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for NT5C1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv577CNV Insertion18451855
    esv2530832CNV Insertion19546169
    nsv7177OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NT5C1A
    DNA2.0 Custom Variant and Variant Library Synthesis for NT5C1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610525    OMIM disorders: --

    9 diseases for NT5C1A:    About MalaCards
    crigler-najjar syndrome    bilirubin metabolic disorder    lateral sclerosis    amyotrophic lateral sclerosis
    infertility    hypoxia    pancreatic cancer    ischemia
    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for NT5C1A:
    Bilirubin metabolic disorder

    NT5C1A for disorders           About GeneDecksing

    Genetic Association Database (GAD): NT5C1A

    Export disorders for NT5C1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NT5C1A gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with NT5C1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance. (PubMed id 11133996)1, 2, 3, 9 Hunsucker S.A.... Mitchell B.S. (J. Biol. Chem. 2001)
    2. Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (PubMed id 11690631)1, 3, 9 Sala-Newby G.B. and Newby A.C. (Biochim. Biophys. Acta 2001)
    3. Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. (PubMed id 19451621)1, 4 Landers J.E....Brown R.H. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Expression of cytosolic 5' nucleotidase does not correlate with expression of oxidative metabolism marker: myoglobine in human skeletal muscles. (PubMed id 19352542)1, 9 Lechward K. and Tkacz-Stachowska K. (Acta Biochim. Biophys. Sin. (Shanghai) 2009)
    7. Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. (PubMed id 21873433)1 Kulkarni S.S....Zierath J.R. (J. Biol. Chem. 2011)
    8. Cell cycle dependent regulation of deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I activity in MOLT-4 cells. (PubMed id 17065091)1 Fyrberg A....Lotfi K. (amp 2006)
    9. Expression of human ecto-5'-nucleotidase in pig endothelium increases adenosine production and protects from NK cell-mediated lysis. (PubMed id 15888028)1 Osborne F.N....Smolenski R.T. (Am. J. Transplant. 2005)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84618 HGNC: 17819 AceView: NT5C1A Ensembl:ENSG00000116981 euGenes: HUgn84618
    ECgene: NT5C1A Kegg: 84618 H-InvDB: NT5C1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for NT5C1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for NT5C1A gene:
    Search GeneIP for patents involving NT5C1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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