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Aliases for NT5C1A Gene

Aliases for NT5C1A Gene

  • 5'-Nucleotidase, Cytosolic IA 2
  • 5-Nucleotidase, Cytosolic IA 2 3 5
  • Cytosolic 5-Nucleotidase IA 2 3 4
  • AMP-Specific 5-NT 2 3
  • CN-IA 3 4
  • CN-I 3 4
  • CN1A 3 4
  • Cytosolic 5 Nucleotidase, Type 1A 3
  • Cytosolic 5 Nucleotidase 2
  • EC 4
  • Type 1A 2
  • CN1 3
  • CNI 3

External Ids for NT5C1A Gene

Previous GeneCards Identifiers for NT5C1A Gene

  • GC01M040154
  • GC01M039128
  • GC01M039588
  • GC01M039538
  • GC01M039793
  • GC01M039897
  • GC01M038243

Summaries for NT5C1A Gene

Entrez Gene Summary for NT5C1A Gene

  • Cytosolic nucleotidases, such as NT5C1A, dephosphorylate nucleoside monophosphates (Hunsucker et al., 2001 [PubMed 11133996]).[supplied by OMIM, Mar 2008]

GeneCards Summary for NT5C1A Gene

NT5C1A (5'-Nucleotidase, Cytosolic IA) is a Protein Coding gene. Among its related pathways are Purine metabolism and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include nucleotide binding and 5-nucleotidase activity. An important paralog of this gene is NT5C1B.

UniProtKB/Swiss-Prot for NT5C1A Gene

  • Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C1A Gene

Genomics for NT5C1A Gene

Regulatory Elements for NT5C1A Gene

Enhancers for NT5C1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NT5C1A on UCSC Golden Path with GeneCards custom track

Genomic Location for NT5C1A Gene

39,659,121 bp from pter
39,672,038 bp from pter
12,918 bases
Minus strand

Genomic View for NT5C1A Gene

Genes around NT5C1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5C1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5C1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5C1A Gene

Proteins for NT5C1A Gene

  • Protein details for NT5C1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytosolic 5-nucleotidase 1A
    Protein Accession:
    Secondary Accessions:
    • Q3SYB9
    • Q5TG98
    • Q9BWT8

    Protein attributes for NT5C1A Gene

    368 amino acids
    Molecular mass:
    41021 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NT5C1A Gene

Proteomics data for NT5C1A Gene at MOPED

Post-translational modifications for NT5C1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NT5C1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NT5C1A Gene

Domains & Families for NT5C1A Gene

Gene Families for NT5C1A Gene

Protein Domains for NT5C1A Gene


Suggested Antigen Peptide Sequences for NT5C1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 5-nucleotidase type 3 family.
  • Belongs to the 5-nucleotidase type 3 family.
genes like me logo Genes that share domains with NT5C1A: view

Function for NT5C1A Gene

Molecular function for NT5C1A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A 5-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by ADP.
UniProtKB/Swiss-Prot Function:
Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.

Enzyme Numbers (IUBMB) for NT5C1A Gene

Phenotypes for NT5C1A Gene

genes like me logo Genes that share phenotypes with NT5C1A: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5C1A Gene

Localization for NT5C1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for NT5C1A Gene


Subcellular locations from

Jensen Localization Image for NT5C1A Gene COMPARTMENTS Subcellular localization image for NT5C1A gene
Compartment Confidence
cytosol 5
nucleus 2
extracellular 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for NT5C1A Gene

Pathways & Interactions for NT5C1A Gene

genes like me logo Genes that share pathways with NT5C1A: view

Interacting Proteins for NT5C1A Gene

Gene Ontology (GO) - Biological Process for NT5C1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0046085 adenosine metabolic process IEA --
GO:0046135 pyrimidine nucleoside catabolic process TAS --
genes like me logo Genes that share ontologies with NT5C1A: view

No data available for SIGNOR curated interactions for NT5C1A Gene

Drugs & Compounds for NT5C1A Gene

(18) Drugs for NT5C1A Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cladribine Approved, Investigational Pharma Apoptosis inducer in CLL cells 68
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1697
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1898
Adenosine Approved, Investigational Pharma Agonist 384
Adenosine monophosphate Approved Nutra 0

(17) Additional Compounds for NT5C1A Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-nicotinamide D-ribonucleotide
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-b-D-Ribofuranose
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-beta-D-Ribofuranose
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-beta-delta-Ribofuranose
  • 2'-Deoxyadenosine
  • 2-Deoxyadenosine
Deoxyadenosine monophosphate
  • 2'-dAMP
  • 2'-Deoxy-5'-adenylate
  • 2'-Deoxy-5'-adenylic acid
  • 2'-Deoxy-Adenosine 5'-phosphorate
  • 2'-Deoxy-Adenosine 5'-phosphoric acid
  • 2'-Deoxy-Guanosine
  • 2'-Deoxyguanosine
  • 2-Deoxyguanosine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)-Guanine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine
genes like me logo Genes that share compounds with NT5C1A: view

Transcripts for NT5C1A Gene

mRNA/cDNA for NT5C1A Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NT5C1A Gene

5-nucleotidase, cytosolic IA:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NT5C1A Gene

No ASD Table

Relevant External Links for NT5C1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5C1A Gene

mRNA expression in normal human tissues for NT5C1A Gene

mRNA differential expression in normal tissues according to GTEx for NT5C1A Gene

This gene is overexpressed in Muscle - Skeletal (x16.7), Heart - Left Ventricle (x6.0), Heart - Atrial Appendage (x6.0), and Brain - Cerebellar Hemisphere (x4.3).

Protein differential expression in normal tissues from HIPED for NT5C1A Gene

This gene is overexpressed in Heart (55.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NT5C1A Gene

SOURCE GeneReport for Unigene cluster for NT5C1A Gene Hs.307006

mRNA Expression by UniProt/SwissProt for NT5C1A Gene

Tissue specificity: Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.
genes like me logo Genes that share expression patterns with NT5C1A: view

Protein tissue co-expression partners for NT5C1A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for NT5C1A Gene

Orthologs for NT5C1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for NT5C1A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NT5C1A 35
  • 91.23 (n)
  • 95.89 (a)
NT5C1A 36
  • 95 (a)
(Canis familiaris)
Mammalia NT5C1A 35
  • 91.3 (n)
  • 95.88 (a)
NT5C1A 36
  • 94 (a)
(Mus musculus)
Mammalia Nt5c1a 35
  • 89.22 (n)
  • 95.62 (a)
Nt5c1a 16
Nt5c1a 36
  • 94 (a)
(Pan troglodytes)
Mammalia NT5C1A 35
  • 99.28 (n)
  • 99.73 (a)
NT5C1A 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Nt5c1a 35
  • 87.63 (n)
  • 95.01 (a)
(Monodelphis domestica)
Mammalia NT5C1A 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia NT5C1A 36
  • 90 (a)
(Gallus gallus)
Aves NT5C1A 35
  • 80.35 (n)
  • 86.42 (a)
NT5C1A 36
  • 83 (a)
(Anolis carolinensis)
Reptilia NT5C1A 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495335 35
  • 71.48 (n)
  • 80.45 (a)
MGC75654 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.8799 35
(Danio rerio)
Actinopterygii LOC799449 35
  • 72.02 (n)
  • 81.97 (a)
nt5c1a 36
  • 66 (a)
NT5C1A (2 of 2) 36
  • 72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5436 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
Species with no ortholog for NT5C1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NT5C1A Gene

Gene Tree for NT5C1A (if available)
Gene Tree for NT5C1A (if available)

Paralogs for NT5C1A Gene

Paralogs for NT5C1A Gene

(2) SIMAP similar genes for NT5C1A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NT5C1A: view

Variants for NT5C1A Gene

Sequence variations from dbSNP and Humsavar for NT5C1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs734497 -- 39,665,417(+) TTGGG(G/T)TTCTG intron-variant
rs752667 -- 39,666,266(+) TGTCA(C/T)TCAGA intron-variant
rs784594 -- 39,665,509(+) CTCAT(G/T)CTCAT intron-variant
rs784595 -- 39,669,345(+) ATTCC(C/T)AGTAG intron-variant
rs784596 -- 39,669,918(+) TGAAA(A/G)ATCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NT5C1A Gene

Variant ID Type Subtype PubMed ID
nsv7177 OTHER Inversion 18451855
nsv577 CNV Insertion 18451855
esv2530832 CNV Insertion 19546169

Variation tolerance for NT5C1A Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NT5C1A Gene

Disorders for NT5C1A Gene

Relevant External Links for NT5C1A

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NT5C1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NT5C1A Gene

Publications for NT5C1A Gene

  1. Human cytosolic 5'-nucleotidase I: characterization and role in nucleoside analog resistance. (PMID: 11133996) Hunsucker S.A. … Mitchell B.S. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (PMID: 11690631) Sala-Newby G.B. … Newby A.C. (Biochim. Biophys. Acta 2001) 2 3 23
  3. Expression of cytosolic 5' nucleotidase does not correlate with expression of oxidative metabolism marker: myoglobine in human skeletal muscles. (PMID: 19352542) Lechward K. … Tkacz-Stachowska K. (Acta Biochim. Biophys. Sin. (Shanghai) 2009) 3 23
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. (PMID: 21873433) Kulkarni S.S. … Zierath J.R. (J. Biol. Chem. 2011) 3

Products for NT5C1A Gene

Sources for NT5C1A Gene