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Aliases for NT5C Gene

Aliases for NT5C Gene

  • 5', 3'-Nucleotidase, Cytosolic 2
  • 5, 3-Nucleotidase, Cytosolic 2 3 5
  • 5 Nucleotidase, Deoxy (Pyrimidine), Cytosolic Type C 2 3
  • Uridine 5-Prime Monophosphate Hydrolase 2 2 3
  • Cytosolic 5,3-Pyrimidine Nucleotidase 3 4
  • Deoxy-5-Nucleotidase 1 3 4
  • UMPH2 3 4
  • DNT-1 3 4
  • DNT1 3 4
  • 5(3)-Deoxyribonucleotidase, Cytosolic Type 3
  • Uridine 5-Monophosphate Phosphohydrolase 2 3
  • Epididymis Luminal Protein 74 3
  • EC 3.1.3.- 4
  • PN-II 3
  • HEL74 3
  • P5N2 3
  • PN-I 3
  • DNT 3
  • CdN 3

External Ids for NT5C Gene

Previous HGNC Symbols for NT5C Gene

  • UMPH2

Previous GeneCards Identifiers for NT5C Gene

  • GC17M073123
  • GC17M076185
  • GC17M073590
  • GC17M073723
  • GC17M070637
  • GC17M068536

Summaries for NT5C Gene

Entrez Gene Summary for NT5C Gene

  • This gene encodes a nucleotidase that catalyzes the dephosphorylation of the 5' deoxyribonucleotides (dNTP) and 2'(3')-dNTP and ribonucleotides, but not 5' ribonucleotides. Of the different forms of nucleotidases characterized, this enzyme is unique in its preference for 5'-dNTP. It may be one of the enzymes involved in regulating the size of dNTP pools in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for NT5C Gene

NT5C (5', 3'-Nucleotidase, Cytosolic) is a Protein Coding gene. Diseases associated with NT5C include Coronin-1A Deficiency and Norwegian Scabies. Among its related pathways are Metabolism and Gemcitabine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include phosphatase activity and nucleotidase activity. An important paralog of this gene is NT5M.

UniProtKB/Swiss-Prot for NT5C Gene

  • Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.

Gene Wiki entry for NT5C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NT5C Gene

Genomics for NT5C Gene

Regulatory Elements for NT5C Gene

Enhancers for NT5C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F074511 1.1 FANTOM5 Ensembl ENCODE 92.4 +618.2 618192 3.3 HDGF PKNOX1 ARNT SIN3A YBX1 FEZF1 ZNF2 ZNF302 CBX5 ZNF416 NUP85 NAT9 NT5C CD300E RN7SL573P LOC100130520 ENSG00000266765 ENSG00000265927 LINC02092 ENSG00000265935
GH17F074448 0.4 ENCODE 48 +681.9 681869 2.1 ZNF493 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF202 SP5 REST NUP85 NAT9 NT5C RN7SL573P GPRC5C GPR142 CD300E CDR2L HID1-AS1 GC17P074445
GH17F075031 1.2 FANTOM5 ENCODE 36.6 +97.2 97175 5.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 ENSG00000266980 NUP85 NT5C UNK ENSG00000264829 ATP5H LOC101928343 HID1 TSEN54 TRIM65
GH17F075782 0.6 ENCODE 34.3 -653.2 -653226 5.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 UNK NUP85 ENSG00000266980 NT5C MFSD11 TRIM65 ENSG00000267342 UNC13D ENSG00000267801 METTL23
GH17F076026 0.7 FANTOM5 ENCODE 30.7 -896.5 -896529 4.1 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF548 NT5C NUP85 UNK ENSG00000266980 HMGN2P43 ENSG00000264829 CDK3 TEN1 METTL23 MYO15B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NT5C on UCSC Golden Path with GeneCards custom track

Promoters for NT5C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001353223 295 2201 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 ZNF207

Genomic Location for NT5C Gene

75,130,225 bp from pter
75,131,795 bp from pter
1,571 bases
Minus strand

Genomic View for NT5C Gene

Genes around NT5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NT5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NT5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NT5C Gene

Proteins for NT5C Gene

  • Protein details for NT5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    5(3)-deoxyribonucleotidase, cytosolic type
    Protein Accession:
    Secondary Accessions:
    • Q96HS6
    • Q9NP82

    Protein attributes for NT5C Gene

    201 amino acids
    Molecular mass:
    23383 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for NT5C Gene

    Alternative splice isoforms for NT5C Gene


neXtProt entry for NT5C Gene

Post-translational modifications for NT5C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NT5C Gene

Domains & Families for NT5C Gene

Gene Families for NT5C Gene

Protein Domains for NT5C Gene

Suggested Antigen Peptide Sequences for NT5C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 5(3)-deoxyribonucleotidase family.
  • Belongs to the 5(3)-deoxyribonucleotidase family.
genes like me logo Genes that share domains with NT5C: view

Function for NT5C Gene

Molecular function for NT5C Gene

UniProtKB/Swiss-Prot Function:
Dephosphorylates the 5 and 2(3)-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.

Enzyme Numbers (IUBMB) for NT5C Gene

Gene Ontology (GO) - Molecular Function for NT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008252 nucleotidase activity IDA 10681516
GO:0008253 5-nucleotidase activity EXP,IEA 2157703
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity IEA --
GO:0019103 pyrimidine nucleotide binding IDA 10681516
genes like me logo Genes that share ontologies with NT5C: view
genes like me logo Genes that share phenotypes with NT5C: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NT5C Gene

Localization for NT5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for NT5C Gene


Subcellular locations from

Jensen Localization Image for NT5C Gene COMPARTMENTS Subcellular localization image for NT5C gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 3
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for NT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10681516
GO:0005737 cytoplasm IDA 10681516
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with NT5C: view

Pathways & Interactions for NT5C Gene

genes like me logo Genes that share pathways with NT5C: view

Gene Ontology (GO) - Biological Process for NT5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006195 purine nucleotide catabolic process TAS --
GO:0009117 nucleotide metabolic process IEA --
GO:0009223 pyrimidine deoxyribonucleotide catabolic process IDA 10681516
GO:0009264 deoxyribonucleotide catabolic process IEA --
GO:0016311 dephosphorylation IEA,IDA 10681516
genes like me logo Genes that share ontologies with NT5C: view

No data available for SIGNOR curated interactions for NT5C Gene

Drugs & Compounds for NT5C Gene

(20) Drugs for NT5C Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lamivudine Approved, Investigational Pharma Enzyme, substrate Nucleoside analog reverse transcriptase inhibitor 613
Adenosine Approved, Investigational Pharma Agonist 397
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine monophosphate Approved Nutra 0

(16) Additional Compounds for NT5C Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-nicotinamide D-ribonucleotide
Cytidine monophosphate
  • 5'-CMP
  • 5-Cytidylate
  • 5-Cytidylic acid
  • CMP
  • Cytidine 5'-monophosphate
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-b-D-Ribofuranose
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-beta-D-Ribofuranose
  • 1-(6-Amino-9H-purin-9-yl)-1,2-dideoxy-beta-delta-Ribofuranose
  • 2'-Deoxyadenosine
  • 2-Deoxyadenosine
Deoxyadenosine monophosphate
  • 2'-dAMP
  • 2'-Deoxy-5'-adenylate
  • 2'-Deoxy-5'-adenylic acid
  • 2'-Deoxy-Adenosine 5'-phosphorate
  • 2'-Deoxy-Adenosine 5'-phosphoric acid
  • 2'-Deoxy-Guanosine
  • 2'-Deoxyguanosine
  • 2-Deoxyguanosine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)-Guanine
  • 9-(2-Deoxy-b-D-erythro-pentofuranosyl)guanine
genes like me logo Genes that share compounds with NT5C: view

Transcripts for NT5C Gene

Unigene Clusters for NT5C Gene

5, 3-nucleotidase, cytosolic:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NT5C Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e · 2f ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: - - - - -
SP2: - - - -
SP4: -
SP5: -
SP7: - -

Relevant External Links for NT5C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NT5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NT5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NT5C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NT5C Gene

Protein tissue co-expression partners for NT5C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NT5C Gene:


SOURCE GeneReport for Unigene cluster for NT5C Gene:


mRNA Expression by UniProt/SwissProt for NT5C Gene:

Tissue specificity: Detected in skeletal muscle, heart and pancreas.
genes like me logo Genes that share expression patterns with NT5C: view

Primer Products

No data available for mRNA differential expression in normal tissues for NT5C Gene

Orthologs for NT5C Gene

This gene was present in the common ancestor of chordates.

Orthologs for NT5C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NT5C 34 35
  • 99.17 (n)
(Canis familiaris)
Mammalia NT5C 34 35
  • 89.38 (n)
(Bos Taurus)
Mammalia NT5C 34 35
  • 86.05 (n)
(Mus musculus)
Mammalia Nt5c 34 16 35
  • 85.96 (n)
(Rattus norvegicus)
Mammalia Nt5c 34
  • 85.79 (n)
(Monodelphis domestica)
Mammalia NT5C 35
  • 69 (a)
(Anolis carolinensis)
Reptilia NT5C 35
  • 66 (a)
Species where no ortholog for NT5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NT5C Gene

Gene Tree for NT5C (if available)
Gene Tree for NT5C (if available)

Paralogs for NT5C Gene

Paralogs for NT5C Gene

(1) SIMAP similar genes for NT5C Gene using alignment to 6 proteins: Pseudogenes for NT5C Gene

genes like me logo Genes that share paralogs with NT5C: view

Variants for NT5C Gene

Sequence variations from dbSNP and Humsavar for NT5C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1048779 -- 75,130,843(-) ACCTG(A/G)GGCCC intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, stop-gained
rs10715821 -- 75,130,652(+) GACAG(-/T)GAAAG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs111483112 -- 75,130,385(+) TCCAC(A/C/G)GGGCC intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs111988834 -- 75,129,871(+) GAAGT(A/G)TATCC downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs112566277 -- 75,131,510(+) TGCCC(A/G)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NT5C Gene

Variant ID Type Subtype PubMed ID
nsv470602 CNV loss 18288195

Variation tolerance for NT5C Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.75; 33.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NT5C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NT5C Gene

Disorders for NT5C Gene

MalaCards: The human disease database

(2) MalaCards diseases for NT5C Gene - From: DISEASES

Disorder Aliases PubMed IDs
coronin-1a deficiency
  • coronin 1a
norwegian scabies
  • crusted scabies
- elite association - COSMIC cancer census association via MalaCards
Search NT5C in MalaCards View complete list of genes associated with diseases

Relevant External Links for NT5C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with NT5C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NT5C Gene

Publications for NT5C Gene

  1. Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA cloning of the mitochondrial enzyme, gene structures, chromosomal mapping and comparison with the human orthologs. (PMID: 12234672) Rampazzo C. … Bianchi V. (Gene 2002) 3 4 22 64
  2. A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease. (PMID: 10899995) Rampazzo C. … Bianchi V. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 22 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Crystal structures of human and murine deoxyribonucleotidases: insights into recognition of substrates and nucleotide analogues. (PMID: 17985935) Wallden K. … Nordlund P. (Biochemistry 2007) 4 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for NT5C Gene

Sources for NT5C Gene

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