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Aliases for NSUN7 Gene

Aliases for NSUN7 Gene

  • NOP2/Sun RNA Methyltransferase Family Member 7 2 3 5
  • NOL1/NOP2/Sun Domain Family, Member 7 2
  • NOL1/NOP2/Sun Domain Family Member 7 4
  • NOP2/Sun Domain Family, Member 7 2
  • EC 2.1.1.- 4

External Ids for NSUN7 Gene

Previous GeneCards Identifiers for NSUN7 Gene

  • GC04P040446
  • GC04P040073

Summaries for NSUN7 Gene

GeneCards Summary for NSUN7 Gene

NSUN7 (NOP2/Sun RNA Methyltransferase Family Member 7) is a Protein Coding gene. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is NSUN5.

UniProtKB/Swiss-Prot for NSUN7 Gene

  • May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSUN7 Gene

Genomics for NSUN7 Gene

Regulatory Elements for NSUN7 Gene

Enhancers for NSUN7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F040840 1.1 Ensembl ENCODE 12.6 +91.0 90976 1.7 PKNOX1 ARID4B SIN3A RAD21 ZNF48 RARA EGR1 ZNF143 CREM ZNF263 ENSG00000250906 NSUN7 ENSG00000207195 GC04M040826 PIR61184
GH04F040749 0.8 ENCODE 12.8 +0.6 579 2.3 GTF2F1 TEAD4 MAX SIN3A E2F1 POLR2A EZH2 CHD2 RFX1 ZNF687 NSUN7 GC04P040789
GH04F040789 0.3 FANTOM5 32.8 +40.1 40084 0.2 NSUN7 ENSG00000250906 GC04P040786
GH04F040806 0.4 Ensembl 24.6 +57.6 57576 1.1 CEBPA ZNF384 NSUN7 ENSG00000250906 GC04P040786
GH04F040729 1.3 FANTOM5 Ensembl ENCODE 7.5 -18.4 -18410 3.3 ELF3 SOX13 ESRRA PKNOX1 SAP130 MAX ZNF384 RAD21 ZNF48 ZNF366 RBM47 ENSG00000250906 NSUN7 GC04P040643
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NSUN7 on UCSC Golden Path with GeneCards custom track

Promoters for NSUN7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001239929 704 2000 GTF2F1 TEAD4 MAX SIN3A E2F1 POLR2A EZH2 CHD2 RFX1 ZNF687

Genomic Location for NSUN7 Gene

Chromosome:
4
Start:
40,749,897 bp from pter
End:
40,809,985 bp from pter
Size:
60,089 bases
Orientation:
Plus strand

Genomic View for NSUN7 Gene

Genes around NSUN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSUN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSUN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSUN7 Gene

Proteins for NSUN7 Gene

  • Protein details for NSUN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE18-NSUN7_HUMAN
    Recommended name:
    Putative methyltransferase NSUN7
    Protein Accession:
    Q8NE18
    Secondary Accessions:
    • C9JI19
    • Q8N9K8
    • Q9H815

    Protein attributes for NSUN7 Gene

    Size:
    718 amino acids
    Molecular mass:
    81039 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04325.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NSUN7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NSUN7 Gene

Post-translational modifications for NSUN7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NSUN7 Gene

No data available for DME Specific Peptides for NSUN7 Gene

Domains & Families for NSUN7 Gene

Gene Families for NSUN7 Gene

Protein Domains for NSUN7 Gene

Suggested Antigen Peptide Sequences for NSUN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NE18

UniProtKB/Swiss-Prot:

NSUN7_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
genes like me logo Genes that share domains with NSUN7: view

Function for NSUN7 Gene

Molecular function for NSUN7 Gene

UniProtKB/Swiss-Prot Function:
May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

Enzyme Numbers (IUBMB) for NSUN7 Gene

Gene Ontology (GO) - Molecular Function for NSUN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NSUN7: view
genes like me logo Genes that share phenotypes with NSUN7: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NSUN7 Gene

Localization for NSUN7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NSUN7 gene
Compartment Confidence
nucleus 2
extracellular 1
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NSUN7 Gene

Pathways & Interactions for NSUN7 Gene

SuperPathways for NSUN7 Gene

No Data Available

Interacting Proteins for NSUN7 Gene

Gene Ontology (GO) - Biological Process for NSUN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with NSUN7: view

No data available for Pathways by source and SIGNOR curated interactions for NSUN7 Gene

Drugs & Compounds for NSUN7 Gene

(1) Drugs for NSUN7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with NSUN7: view

Transcripts for NSUN7 Gene

Unigene Clusters for NSUN7 Gene

NOP2/Sun domain family, member 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSUN7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2:
SP3:

Relevant External Links for NSUN7 Gene

GeneLoc Exon Structure for
NSUN7
ECgene alternative splicing isoforms for
NSUN7

Expression for NSUN7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NSUN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NSUN7 Gene

This gene is overexpressed in Whole Blood (x9.9) and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for NSUN7 Gene

This gene is overexpressed in Lung (22.2), Gallbladder (9.6), Kidney (8.1), Liver (6.6), Heart (6.4), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NSUN7 Gene



NURSA nuclear receptor signaling pathways regulating expression of NSUN7 Gene:

NSUN7

SOURCE GeneReport for Unigene cluster for NSUN7 Gene:

Hs.570821
genes like me logo Genes that share expression patterns with NSUN7: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for NSUN7 Gene

Orthologs for NSUN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NSUN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NSUN7 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia NSUN7 34 35
  • 88.42 (n)
cow
(Bos Taurus)
Mammalia NSUN7 34 35
  • 87.24 (n)
rat
(Rattus norvegicus)
Mammalia Nsun7 34
  • 79.25 (n)
mouse
(Mus musculus)
Mammalia Nsun7 34 16 35
  • 75.77 (n)
oppossum
(Monodelphis domestica)
Mammalia NSUN7 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NSUN7 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves NSUN7 34 35
  • 64.2 (n)
lizard
(Anolis carolinensis)
Reptilia NSUN7 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nsun7 34
  • 59.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19380 34
zebrafish
(Danio rerio)
Actinopterygii NSUN7 35
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13035 35
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 17 (a)
OneToMany
Species where no ortholog for NSUN7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSUN7 Gene

ENSEMBL:
Gene Tree for NSUN7 (if available)
TreeFam:
Gene Tree for NSUN7 (if available)

Paralogs for NSUN7 Gene

Paralogs for NSUN7 Gene

genes like me logo Genes that share paralogs with NSUN7: view

Variants for NSUN7 Gene

Sequence variations from dbSNP and Humsavar for NSUN7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10006071 -- 40,764,480(+) atcat(C/T)gttgg intron-variant
rs10007725 -- 40,810,749(+) TCAAA(A/C)ACTAT downstream-variant-500B, utr-variant-3-prime
rs10014919 -- 40,772,716(+) ATTTA(C/T)TACCC intron-variant
rs10020152 -- 40,779,601(+) tgttt(C/T)gaaaa intron-variant
rs10020781 -- 40,777,328(+) TTTTT(A/T)TAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NSUN7 Gene

Variant ID Type Subtype PubMed ID
dgv1476e212 CNV gain 25503493
dgv5195n100 CNV gain 25217958
dgv9023n54 CNV gain 21841781
esv1008692 CNV insertion 20482838
esv3310571 CNV novel sequence insertion 20981092
esv3369721 CNV insertion 20981092
esv3435455 CNV insertion 20981092
esv3600317 CNV gain 21293372
nsv10486 CNV gain 18304495
nsv290937 CNV insertion 16902084
nsv4307 CNV deletion 18451855
nsv461344 CNV gain 19166990
nsv525845 CNV gain 19592680
nsv829911 CNV gain 17160897
nsv829912 CNV loss 17160897
nsv967741 CNV duplication 23825009
nsv999749 CNV gain 25217958

Variation tolerance for NSUN7 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NSUN7 Gene

Human Gene Mutation Database (HGMD)
NSUN7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NSUN7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSUN7 Gene

Disorders for NSUN7 Gene

Relevant External Links for NSUN7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NSUN7

No disorders were found for NSUN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSUN7 Gene

Publications for NSUN7 Gene

  1. Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. (PMID: 17442852) Harris T. … Schimenti J. (Biol. Reprod. 2007) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The Nsun7 (A11337)-deletion mutation, causes reduction of its protein rate and associated with sperm motility defect in infertile men. (PMID: 25702163) Khosronezhad N. … Mortazavi S.M. (J. Assist. Reprod. Genet. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Investigation of polymorphisms in exon7 of the NSUN7 gene among Chinese Han men with asthenospermia. (PMID: 26345859) Ren H.Y. … Jing Y.L. (Genet. Mol. Res. 2015) 3 64

Products for NSUN7 Gene

Sources for NSUN7 Gene

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