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Aliases for NSUN7 Gene

Aliases for NSUN7 Gene

  • NOP2/Sun Domain Family, Member 7 2 3
  • NOL1/NOP2/Sun Domain Family, Member 7 2
  • NOL1/NOP2/Sun Domain Family Member 7 4
  • EC 2.1.1.- 4

External Ids for NSUN7 Gene

Previous GeneCards Identifiers for NSUN7 Gene

  • GC04P040446
  • GC04P040073

Summaries for NSUN7 Gene

GeneCards Summary for NSUN7 Gene

NSUN7 (NOP2/Sun Domain Family, Member 7) is a Protein Coding gene. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is NSUN5.

UniProtKB/Swiss-Prot for NSUN7 Gene

  • May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSUN7 Gene

Genomics for NSUN7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NSUN7 Gene

40,749,897 bp from pter
40,809,985 bp from pter
60,089 bases
Plus strand

Genomic View for NSUN7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NSUN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSUN7 Gene

Proteins for NSUN7 Gene

  • Protein details for NSUN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative methyltransferase NSUN7
    Protein Accession:
    Secondary Accessions:
    • C9JI19
    • Q8N9K8
    • Q9H815

    Protein attributes for NSUN7 Gene

    718 amino acids
    Molecular mass:
    81039 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC04325.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NSUN7 Gene


neXtProt entry for NSUN7 Gene

Proteomics data for NSUN7 Gene at MOPED

Post-translational modifications for NSUN7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NSUN7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for NSUN7 Gene

Domains for NSUN7 Gene

Gene Families for NSUN7 Gene

Protein Domains for NSUN7 Gene

Suggested Antigen Peptide Sequences for NSUN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
genes like me logo Genes that share domains with NSUN7: view

Function for NSUN7 Gene

Molecular function for NSUN7 Gene

UniProtKB/Swiss-Prot Function:
May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

Enzyme Numbers (IUBMB) for NSUN7 Gene

Gene Ontology (GO) - Molecular Function for NSUN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with NSUN7: view

Phenotypes for NSUN7 Gene

MGI mutant phenotypes for NSUN7:
inferred from 1 alleles
GenomeRNAi human phenotypes for NSUN7:
genes like me logo Genes that share phenotypes with NSUN7: view

Animal Model Products

miRNA for NSUN7 Gene

miRTarBase miRNAs that target NSUN7

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for NSUN7 Gene

Localization for NSUN7 Gene

Subcellular locations from

Jensen Localization Image for NSUN7 Gene COMPARTMENTS Subcellular localization image for NSUN7 gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NSUN7 Gene

Pathways for NSUN7 Gene

SuperPathways for NSUN7 Gene

No Data Available

Interacting Proteins for NSUN7 Gene

Gene Ontology (GO) - Biological Process for NSUN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with NSUN7: view

No data available for Pathways by source for NSUN7 Gene

Drugs for NSUN7 Gene

(1) HMDB Compounds for NSUN7 Gene

Compound Synonyms Cas Number PubMed IDs
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
genes like me logo Genes that share compounds with NSUN7: view

Transcripts for NSUN7 Gene

Unigene Clusters for NSUN7 Gene

NOP2/Sun domain family, member 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NSUN7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSUN7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -

Relevant External Links for NSUN7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NSUN7 Gene

mRNA expression in normal human tissues for NSUN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NSUN7 Gene

This gene is overexpressed in Whole Blood (9.9) and Testis (4.3).

Protein differential expression in normal tissues for NSUN7 Gene

This gene is overexpressed in Lung (22.2), Gallbladder (9.6), Kidney (8.1), Liver (6.6), Heart (6.4), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NSUN7 Gene

SOURCE GeneReport for Unigene cluster for NSUN7 Gene Hs.570821

genes like me logo Genes that share expressions with NSUN7: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for NSUN7 Gene

Orthologs for NSUN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NSUN7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NSUN7 35
  • 87.24 (n)
  • 81.35 (a)
NSUN7 36
  • 80 (a)
(Canis familiaris)
Mammalia NSUN7 35
  • 88.42 (n)
  • 83.07 (a)
NSUN7 36
  • 80 (a)
(Mus musculus)
Mammalia Nsun7 35
  • 75.77 (n)
  • 71.94 (a)
Nsun7 16
Nsun7 36
  • 67 (a)
(Pan troglodytes)
Mammalia NSUN7 35
  • 99.54 (n)
  • 99.03 (a)
NSUN7 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nsun7 35
  • 79.25 (n)
  • 71.76 (a)
(Monodelphis domestica)
Mammalia NSUN7 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia NSUN7 36
  • 47 (a)
(Gallus gallus)
Aves NSUN7 35
  • 64.2 (n)
  • 52.82 (a)
NSUN7 36
  • 48 (a)
(Anolis carolinensis)
Reptilia NSUN7 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nsun7 35
  • 59.54 (n)
  • 49.43 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19380 35
(Danio rerio)
Actinopterygii NSUN7 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13035 36
  • 14 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 17 (a)
Species with no ortholog for NSUN7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSUN7 Gene

Gene Tree for NSUN7 (if available)
Gene Tree for NSUN7 (if available)

Paralogs for NSUN7 Gene

Paralogs for NSUN7 Gene

genes like me logo Genes that share paralogs with NSUN7: view

Variants for NSUN7 Gene

Sequence variations from dbSNP and Humsavar for NSUN7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs55846151 -- 40,780,788(+) ACACA(C/T)ACACA intron-variant
rs55738012 -- 40,797,821(+) AGTCC(C/G)TGTAC intron-variant
rs55690540 -- 40,748,153(+) GGGGG(G/T)AATGC upstream-variant-2KB
rs35808882 -- 40,749,175(+) AAGGA(-/T)TTTTT upstream-variant-2KB
rs35774073 -- 40,803,720(+) AACAA(-/A)TCACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NSUN7 Gene

Variant ID Type Subtype PubMed ID
nsv829911 CNV Gain 17160897
nsv461344 CNV Gain 19166990
nsv525845 CNV Gain 19592680
nsv829912 CNV Loss 17160897
nsv10486 CNV Gain 18304495
esv1008692 CNV Insertion 20482838
nsv290937 CNV Insertion 16902084
nsv4307 CNV Loss 18451855

Relevant External Links for NSUN7 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSUN7 Gene

Disorders for NSUN7 Gene

No disorders were found for NSUN7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for NSUN7 Gene

Publications for NSUN7 Gene

  1. Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. (PMID: 17442852) Harris T. … Schimenti J. (Biol. Reprod. 2007) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for NSUN7 Gene

Sources for NSUN7 Gene

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