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Aliases for NSUN7 Gene

Aliases for NSUN7 Gene

  • NOP2/Sun Domain Family, Member 7 2 3
  • NOL1/NOP2/Sun Domain Family, Member 7 2
  • NOL1/NOP2/Sun Domain Family Member 7 4
  • EC 2.1.1.- 4

External Ids for NSUN7 Gene

Summaries for NSUN7 Gene

GeneCards Summary for NSUN7 Gene

NSUN7 (NOP2/Sun Domain Family, Member 7) is a Protein Coding gene. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is NSUN5.

UniProtKB/Swiss-Prot for NSUN7 Gene

  • May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSUN7 Gene

Genomics for NSUN7 Gene

Genomic Location for NSUN7 Gene

Start:
40,749,897 bp from pter
End:
40,809,985 bp from pter
Size:
60,089 bases
Orientation:
Plus strand

Genomic View for NSUN7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NSUN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSUN7 Gene

Proteins for NSUN7 Gene

  • Protein details for NSUN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE18-NSUN7_HUMAN
    Recommended name:
    Putative methyltransferase NSUN7
    Protein Accession:
    Q8NE18
    Secondary Accessions:
    • C9JI19
    • Q8N9K8
    • Q9H815

    Protein attributes for NSUN7 Gene

    Size:
    718 amino acids
    Molecular mass:
    81039 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04325.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NSUN7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NSUN7 Gene

Proteomics data for NSUN7 Gene at MOPED

Post-translational modifications for NSUN7 Gene

No Post-translational modifications

Other Protein References for NSUN7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NSUN7 Gene

Domains for NSUN7 Gene

Gene Families for NSUN7 Gene

HGNC:
  • NSUN :NOP2/Sun domain containing

Protein Domains for NSUN7 Gene

UniProtKB/Swiss-Prot:

NSUN7_HUMAN
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.:
    • Q8NE18
genes like me logo Genes that share domains with NSUN7: view

Function for NSUN7 Gene

Molecular function for NSUN7 Gene

UniProtKB/Swiss-Prot Function: May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

Enzyme Numbers (IUBMB) for NSUN7 Gene

Gene Ontology (GO) - Molecular Function for NSUN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008168 methyltransferase activity IEA --
genes like me logo Genes that share ontologies with NSUN7: view

Phenotypes for NSUN7 Gene

MGI mutant phenotypes for NSUN7:
inferred from 1 alleles
GenomeRNAi human phenotypes for NSUN7:
genes like me logo Genes that share phenotypes with NSUN7: view

miRNA for NSUN7 Gene

miRTarBase miRNAs that target NSUN7

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for NSUN7 Gene

Localization for NSUN7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NSUN7 Gene COMPARTMENTS Subcellular localization image for NSUN7 gene
Compartment Confidence
nucleus 2
cytosol 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for NSUN7 Gene

Pathways for NSUN7 Gene

SuperPathways for NSUN7 Gene

No Data Available

Interacting Proteins for NSUN7 Gene

Gene Ontology (GO) - Biological Process for NSUN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with NSUN7: view

No data available for Pathways by source for NSUN7 Gene

Compounds for NSUN7 Gene

(1) HMDB Compounds for NSUN7 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with NSUN7: view

Transcripts for NSUN7 Gene

Unigene Clusters for NSUN7 Gene

NOP2/Sun domain family, member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NSUN7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2:
SP3:

Relevant External Links for NSUN7 Gene

GeneLoc Exon Structure for
NSUN7
ECgene alternative splicing isoforms for
NSUN7

Expression for NSUN7 Gene

mRNA expression in normal human tissues for NSUN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NSUN7 Gene

This gene is overexpressed in Whole Blood (9.9) and Testis (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NSUN7 Gene

SOURCE GeneReport for Unigene cluster for NSUN7 Gene Hs.570821

genes like me logo Genes that share expressions with NSUN7: view

Orthologs for NSUN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NSUN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NSUN7 36
  • 99.54 (n)
  • 99.03 (a)
NSUN7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NSUN7 36
  • 87.24 (n)
  • 81.35 (a)
NSUN7 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NSUN7 36
  • 88.42 (n)
  • 83.07 (a)
NSUN7 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nsun7 36
  • 75.77 (n)
  • 71.94 (a)
Nsun7 16
Nsun7 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NSUN7 37
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NSUN7 37
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nsun7 36
  • 79.25 (n)
  • 71.76 (a)
chicken
(Gallus gallus)
Aves NSUN7 36
  • 64.2 (n)
  • 52.82 (a)
NSUN7 37
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NSUN7 37
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19380 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nsun7 36
  • 59.54 (n)
  • 49.43 (a)
zebrafish
(Danio rerio)
Actinopterygii NSUN7 37
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13035 37
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 17 (a)
OneToMany
Species with no ortholog for NSUN7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSUN7 Gene

ENSEMBL:
Gene Tree for NSUN7 (if available)
TreeFam:
Gene Tree for NSUN7 (if available)

Paralogs for NSUN7 Gene

Paralogs for NSUN7 Gene

genes like me logo Genes that share paralogs with NSUN7: view

Variants for NSUN7 Gene

Sequence variations from dbSNP and Humsavar for NSUN7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs882733 -- 40,808,961(-) TTGGC(C/T)CCTAT utr-variant-3-prime
rs882734 -- 40,807,991(+) gctga(A/G)atcgc intron-variant
rs1435645 -- 40,789,135(+) TCTTT(C/G)TCTCT intron-variant
rs1435646 -- 40,789,139(+) TCTCT(C/T)TGTCC intron-variant
rs1545077 -- 40,752,137(-) TTTCT(A/G)GAACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NSUN7 Gene

Variant ID Type Subtype PubMed ID
nsv829911 CNV Gain 17160897
nsv461344 CNV Gain 19166990
nsv525845 CNV Gain 19592680
nsv829912 CNV Loss 17160897
nsv10486 CNV Gain 18304495
esv1008692 CNV Insertion 20482838
nsv290937 CNV Insertion 16902084
nsv4307 CNV Loss 18451855

Relevant External Links for NSUN7 Gene

HapMap Linkage Disequilibrium report
NSUN7
Human Gene Mutation Database (HGMD)
NSUN7

Disorders for NSUN7 Gene

No disorders were found for NSUN7 Gene.

No data available for UniProtKB/Swiss-Prot for NSUN7 Gene

Publications for NSUN7 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. (PMID: 17442852) Harris T. … Schimenti J. (Biol. Reprod. 2007) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for NSUN7 Gene

Sources for NSUN7 Gene

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