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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NSUN7 Gene

protein-coding   GIFtS: 46
GCID: GC04P040751

NOP2/Sun domain family, member 7

(Previous names: NOL1/NOP2/Sun domain family, member 7 )
 Explore 1 disease affiliated with
NSUN7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for NSUN7    

Aliases
for NSUN7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
NOP2/Sun Domain Family, Member 71 2
NOL1/NOP2/Sun Domain Family, Member 71 2
NOL1/NOP2/Sun Domain Family Member 72 3
FLJ140011
Putative Methyltransferase NSUN72
EC 2.1.1.-3

External Ids:    HGNC: 258571   Entrez Gene: 797302   Ensembl: ENSG000001792997   UniProtKB: Q8NE183   

Export aliases for NSUN7 gene to outside databases

Previous GC identifers: GC04P040446 GC04P040073


Summaries
for NSUN7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: NSUN7_HUMAN, Q8NE18
Function: May have S-adenosyl-L-methionine-dependent methyl-transferase activity (Potential)




Genomic Views
for NSUN7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006238.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NSUN7 gene promoter:
         POU2F2 (Oct-2.1)   RFX1   POU2F2   POU2F2C   PPAR-alpha   POU2F1a   IRF-7A   SEF-1 (1)   NF-kappaB1   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: NSUN7 promoter sequence
   Search SABiosciences Chromatin IP Primers for NSUN7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NSUN7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

NSUN7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NSUN7 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P040751:  view genomic region     (about GC identifiers)

Start:
 40,751,914 bp from pter      End:
 40,812,002 bp from pter
Size:
 60,089 bases      Orientation:
 plus strand

Proteins
for NSUN7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NSUN7_HUMAN, Q8NE18 (See protein sequence)
Recommended Name: Putative methyltransferase NSUN7  
Size: 718 amino acids; 81039 Da
Sequence caution: Sequence=BAC04325.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: C9JI19 Q8N9K8 Q9H815
Alternative splicing: 3 isoforms:  Q8NE18-1   Q8NE18-2   Q8NE18-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NSUN7: NX_Q8NE18

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NE18

    • NSUN7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_078953.3  
    ENSEMBL proteins: 
     ENSP00000371201   ENSP00000319127  

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    Protein Domains /
    Families
    for NSUN7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    NSUN7 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001678 Fmu/NOL1/Nop2p

    Graphical View of Domain Structure for InterPro Entry Q8NE18

    ProtoNet protein and cluster: Q8NE18

    UniProtKB/Swiss-Prot: NSUN7_HUMAN, Q8NE18
    Similarity: Belongs to the methyltransferase superfamily. RsmB/NOP family


    Function
    for NSUN7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: NSUN7_HUMAN, Q8NE18
    Function: May have S-adenosyl-L-methionine-dependent methyl-transferase activity (Potential)

    Enzyme Number (IUBMB): EC 2.1.1.-1

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate NSUN7 (see all 10):
    hsa-miR-203 hsa-miR-187* hsa-miR-1267 hsa-miR-548v hsa-miR-222 hsa-miR-221 hsa-miR-744* hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NSUN7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NSUN7 (see all 7)
    OriGene shRNA RFP: NSUN7
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for NSUN7

    Clone
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    Search LifeMap BioReagents cell lines for NSUN7

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSUN7

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity IEA--


    NSUN7 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for NSUN7:
     Synthetic lethal with Ras 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Nsun7):
     reproductive system 

    NSUN7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for NSUN7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NSUN7

    Drugs & Compounds
    for NSUN7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NSUN7

    1 HMDB Compound for NSUN7    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Search CenterWatch for drugs/clinical trials and news about NSUN7 

    Transcripts
    for NSUN7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for NSUN7 gene: 
    NM_024677.4  

    Unigene Cluster for NSUN7:

    NOP2/Sun domain family, member 7
    Hs.570821  [show with all ESTs]
    Unigene Representative Sequence: BC042401
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381782(uc003gvj.4 uc003gvi.4) ENST00000316607 ENST00000473399(uc003gvh.2)
    ENST00000463952 ENST00000469033 ENST00000423784 ENST00000478857

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NSUN7
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate NSUN7 (see all 10):
    hsa-miR-203 hsa-miR-187* hsa-miR-1267 hsa-miR-548v hsa-miR-222 hsa-miR-221 hsa-miR-744* hsa-miR-338-5p
    SwitchGear 3'UTR luciferase reporter plasmid: NSUN7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NSUN7 (see all 7)
    OriGene shRNA RFP: NSUN7
    OriGene siRNA: NSUN7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NSUN7
    Clone
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    GenScript: all cDNA clones in your preferred vector: NSUN7 (NM_024677)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSUN7 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NSUN7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NSUN7

    Additional cDNA sequence: 

    AK024063.1 AK094298.1 AK130348.1 AK304048.1 BC036568.2 BC042401.1 

    5 DOTS entries:

    DT.306651  DT.104578  DT.95192925  DT.100748519  DT.91734382 

    24/55 AceView cDNA sequences (see all 55):

    BE550959 AA233610 BM781928 AI216832 AU143669 AI275210 BC042401 AK094298 
    AI221215 BM844846 AA055869 AI961502 BG718408 BI463713 AI538394 AK024063 
    BC036568 BX113523 NM_024677 BE222110 BF431637 BE042919 AA448524 BQ023150 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for NSUN7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                            -                             -         
    SP2:                                                                                    
    SP3:                                                                                    


    ECgene alternative splicing isoforms for NSUN7

    Expression
    for NSUN7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NSUN7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAACAGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    NSUN7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See NSUN7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NSUN7

    SOURCE GeneReport for Unigene cluster: Hs.570821
        SABiosciences Custom PCR Arrays for NSUN7
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSUN7

    Orthologs
    for NSUN7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for NSUN7 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Nsun71 , 5 NOL1/NOP2/Sun domain family, member 71, 5 75.71(n)1
    71.54(a)1    		   5 (34.34 cM)5
    709181  NM_027602.11  NP_081878.11 
     662599125 
    chicken
    (Gallus gallus)    		 Aves NSUN71 NOP2/Sun domain family, member 7 64.68(n)
    53.06(a)    		   422782  XM_420736.3  XP_420736.3 
    lizard
    (Anolis carolinensis)    		 Reptilia NSUN76
    		 --
    		 56(a)
    		 1 ↔ 1
    		 5(100217246-100242524)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.193802 Xenopus laevis transcribed sequence with weak similarity more 72.03(n)    BQ385079.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BX119979.16
    		 --
    		 39(a)
    		 1 ↔ 1
    		 1(18783254-18785561)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG130356
    		 --
    		 14(a)
    		 1 ↔ 1
    		 3L(16389953-16393157)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT5G261806
    		 NOL1/NOP2/sun family protein
    		 19(a)
    		 1 → many
    		 5(9149227-9153502)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 NOL1/NOP2/sun family protein, putative, expressed
    		 20(a)
    		 1 → many
    		 2(6582328-6588245)


    ENSEMBL Gene Tree for NSUN7 (if available)
    TreeFam Gene Tree for NSUN7 (if available) 

    Paralogs
    for NSUN7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for NSUN7 gene
    NSUN52  

    NSUN7 for paralogs           About GeneDecksing



    Genomic Variants
    for NSUN7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for NSUN7
         1 CNV: 31169
    Human Gene Mutation Database (HGMD): NSUN7
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NSUN7
    DNA2.0 Custom Variant and Variant Library Synthesis for NSUN7

    Disorders / Diseases
    for NSUN7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    NSUN7 for disorders           About GeneDecksing

    1 disease for NSUN7:    About MalaCards
    infertility


    Export disorders for NSUN7 gene to outside databases

    Publications
    for NSUN7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NSUN7 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with NSUN7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. (PubMed id 17442852)1, 3 Harris T....Schimenti J. (2007)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for NSUN7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NSUN7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79730 HGNC: 25857 AceView: FLJ14001 Ensembl:ENSG00000179299 euGenes: HUgn79730
    ECgene: NSUN7 H-InvDB: NSUN7

    Other Databases showing NSUN7 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NSUN7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NSUN7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for NSUN7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for NSUN7 gene:
    Search GeneIP for patents involving NSUN7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NSUN7 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    von Willebrand factor
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