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Aliases for NSUN7 Gene

Aliases for NSUN7 Gene

  • NOP2/Sun RNA Methyltransferase Family Member 7 2 3 5
  • NOL1/NOP2/Sun Domain Family, Member 7 2
  • NOL1/NOP2/Sun Domain Family Member 7 4
  • NOP2/Sun Domain Family, Member 7 2
  • EC 2.1.1.- 4

External Ids for NSUN7 Gene

Previous GeneCards Identifiers for NSUN7 Gene

  • GC04P040446
  • GC04P040073

Summaries for NSUN7 Gene

GeneCards Summary for NSUN7 Gene

NSUN7 (NOP2/Sun RNA Methyltransferase Family Member 7) is a Protein Coding gene. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is NSUN5.

UniProtKB/Swiss-Prot for NSUN7 Gene

  • May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

Additional gene information for NSUN7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSUN7 Gene

Genomics for NSUN7 Gene

Regulatory Elements for NSUN7 Gene

Enhancers for NSUN7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H040749 1.1 Ensembl ENCODE 12.8 +0.7 676 2 GTF2F1 NFIB MAX SIN3A CEBPG BMI1 ZBTB7B BRCA1 RFX5 ETS1 NSUN7 ARL4AP2 GC04P040789
GH04H040840 1.1 Ensembl ENCODE 12.6 +91.0 90976 1 PKNOX1 ARID4B SIN3A RAD21 EGR1 ZNF143 FOS ATF7 RUNX3 CREM ENSG00000250906 NSUN7 ENSG00000207195 GC04M040826 PIR61184
GH04H040806 0.5 Ensembl 24.6 +57.6 57576 1 CEBPA HNF4A ZNF384 NSUN7 ENSG00000250906 GC04P040786
GH04H040729 1.5 FANTOM5 Ensembl ENCODE dbSUPER 7.5 -18.4 -18410 3 SOX5 SOX13 MXI1 SAP130 NFIA NR2F1 MAX REST RAD21 POLR2A RBM47 ENSG00000250906 NSUN7 GC04P040643
GH04H040789 0.3 FANTOM5 32.8 +40.1 40084 0 NSUN7 ENSG00000250906 GC04P040786
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NSUN7 on UCSC Golden Path with GeneCards custom track

Promoters for NSUN7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167777 504 1599 GTF2F1 NFIB MAX SIN3A BMI1 ZBTB7B BRCA1 RFX5 ETS1 E2F1

Genomic Location for NSUN7 Gene

Chromosome:
4
Start:
40,749,897 bp from pter
End:
40,809,985 bp from pter
Size:
60,089 bases
Orientation:
Plus strand

Genomic View for NSUN7 Gene

Genes around NSUN7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSUN7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSUN7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSUN7 Gene

Proteins for NSUN7 Gene

  • Protein details for NSUN7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NE18-NSUN7_HUMAN
    Recommended name:
    Putative methyltransferase NSUN7
    Protein Accession:
    Q8NE18
    Secondary Accessions:
    • C9JI19
    • Q8N9K8
    • Q9H815

    Protein attributes for NSUN7 Gene

    Size:
    718 amino acids
    Molecular mass:
    81039 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04325.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for NSUN7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NSUN7 Gene

Post-translational modifications for NSUN7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NSUN7 Gene

No data available for DME Specific Peptides for NSUN7 Gene

Domains & Families for NSUN7 Gene

Gene Families for NSUN7 Gene

Protein Domains for NSUN7 Gene

Suggested Antigen Peptide Sequences for NSUN7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NE18

UniProtKB/Swiss-Prot:

NSUN7_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
genes like me logo Genes that share domains with NSUN7: view

Function for NSUN7 Gene

Molecular function for NSUN7 Gene

UniProtKB/Swiss-Prot Function:
May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

Enzyme Numbers (IUBMB) for NSUN7 Gene

Gene Ontology (GO) - Molecular Function for NSUN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NSUN7: view
genes like me logo Genes that share phenotypes with NSUN7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NSUN7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NSUN7 Gene

Localization for NSUN7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NSUN7 gene
Compartment Confidence
nucleus 2
extracellular 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NSUN7 Gene

Pathways & Interactions for NSUN7 Gene

SuperPathways for NSUN7 Gene

No Data Available

Interacting Proteins for NSUN7 Gene

Gene Ontology (GO) - Biological Process for NSUN7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with NSUN7: view

No data available for Pathways by source and SIGNOR curated interactions for NSUN7 Gene

Drugs & Compounds for NSUN7 Gene

(1) Additional Compounds for NSUN7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
29908-03-0
genes like me logo Genes that share compounds with NSUN7: view

Transcripts for NSUN7 Gene

Unigene Clusters for NSUN7 Gene

NOP2/Sun domain family, member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NSUN7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NSUN7 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - -
SP2:
SP3:

Relevant External Links for NSUN7 Gene

GeneLoc Exon Structure for
NSUN7
ECgene alternative splicing isoforms for
NSUN7

Expression for NSUN7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NSUN7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NSUN7 Gene

This gene is overexpressed in Whole Blood (x9.9) and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for NSUN7 Gene

This gene is overexpressed in Lung (22.2), Gallbladder (9.6), Kidney (8.1), Liver (6.6), Heart (6.4), and CD4 Tcells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NSUN7 Gene



NURSA nuclear receptor signaling pathways regulating expression of NSUN7 Gene:

NSUN7

SOURCE GeneReport for Unigene cluster for NSUN7 Gene:

Hs.570821

Evidence on tissue expression from TISSUES for NSUN7 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with NSUN7: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NSUN7 Gene

Orthologs for NSUN7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NSUN7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NSUN7 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia NSUN7 33 34
  • 88.42 (n)
cow
(Bos Taurus)
Mammalia NSUN7 33 34
  • 87.24 (n)
rat
(Rattus norvegicus)
Mammalia Nsun7 33
  • 79.25 (n)
mouse
(Mus musculus)
Mammalia Nsun7 33 16 34
  • 75.77 (n)
oppossum
(Monodelphis domestica)
Mammalia NSUN7 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NSUN7 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves NSUN7 33 34
  • 64.2 (n)
lizard
(Anolis carolinensis)
Reptilia NSUN7 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nsun7 33
  • 59.54 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19380 33
zebrafish
(Danio rerio)
Actinopterygii NSUN7 34
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13035 34
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 17 (a)
OneToMany
Species where no ortholog for NSUN7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSUN7 Gene

ENSEMBL:
Gene Tree for NSUN7 (if available)
TreeFam:
Gene Tree for NSUN7 (if available)

Paralogs for NSUN7 Gene

Paralogs for NSUN7 Gene

genes like me logo Genes that share paralogs with NSUN7: view

Variants for NSUN7 Gene

Sequence variations from dbSNP and Humsavar for NSUN7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000015640 -- 40,770,142(+) GAGGC(A/G)GAGGT intron-variant
rs1000015877 -- 40,783,246(+) GTTGC(C/G)AAGAC intron-variant
rs1000084268 -- 40,759,727(+) ATGAA(C/T)ATACA intron-variant
rs1000120602 -- 40,760,316(+) TTGAG(A/G)TATAT intron-variant
rs1000150326 -- 40,760,890(+) TTAAA(C/T)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NSUN7 Gene

Variant ID Type Subtype PubMed ID
dgv1476e212 CNV gain 25503493
dgv5195n100 CNV gain 25217958
dgv9023n54 CNV gain 21841781
esv1008692 CNV insertion 20482838
esv3310571 CNV novel sequence insertion 20981092
esv3369721 CNV insertion 20981092
esv3435455 CNV insertion 20981092
esv3600317 CNV gain 21293372
nsv10486 CNV gain 18304495
nsv290937 CNV insertion 16902084
nsv4307 CNV deletion 18451855
nsv461344 CNV gain 19166990
nsv525845 CNV gain 19592680
nsv829911 CNV gain 17160897
nsv829912 CNV loss 17160897
nsv967741 CNV duplication 23825009
nsv999749 CNV gain 25217958

Variation tolerance for NSUN7 Gene

Residual Variation Intolerance Score: 78.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NSUN7 Gene

Human Gene Mutation Database (HGMD)
NSUN7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NSUN7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSUN7 Gene

Disorders for NSUN7 Gene

Relevant External Links for NSUN7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NSUN7

No disorders were found for NSUN7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSUN7 Gene

Publications for NSUN7 Gene

  1. Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. (PMID: 17442852) Harris T … Schimenti J (Biology of reproduction 2007) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. T26248G-transversion mutation in exon7 of the putative methyltransferase Nsun7 gene causes a change in protein folding associated with reduced sperm motility in asthenospermic men. (PMID: 24384068) Khosronezhad N … Jorsarayi SG (Reproduction, fertility, and development 2015) 3 60

Products for NSUN7 Gene

Sources for NSUN7 Gene

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