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Aliases for NSUN6 Gene

Aliases for NSUN6 Gene

  • NOP2/Sun RNA Methyltransferase Family Member 6 2 3 5
  • NOL1/NOP2/Sun And PUA Domain-Containing Protein 1 3 4
  • NOL1/NOP2/Sun Domain Family, Member 6 2 3
  • NOP2/Sun Domain Family, Member 6 2 3
  • ARL5B Antisense RNA 1 2 3
  • NOPD1 3 4
  • Nucleolar Protein (NOL1/NOP2/Sun) And PUA Domains 1 3
  • NOL1/NOP2/Sun Domain Family Member 6 4
  • 4933414E04Rik 3
  • EC 63
  • EC 2.1.1.- 4
  • ARL5B-AS1 3
  • EC 2.1.1 63

External Ids for NSUN6 Gene

Previous HGNC Symbols for NSUN6 Gene

  • NOPD1
  • ARL5B-AS1

Previous GeneCards Identifiers for NSUN6 Gene

  • GC10M018874
  • GC10M018499

Summaries for NSUN6 Gene

GeneCards Summary for NSUN6 Gene

NSUN6 (NOP2/Sun RNA Methyltransferase Family Member 6) is a Protein Coding gene. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is NSUN3.

UniProtKB/Swiss-Prot for NSUN6 Gene

  • May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSUN6 Gene

Genomics for NSUN6 Gene

Regulatory Elements for NSUN6 Gene

Enhancers for NSUN6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NSUN6 on UCSC Golden Path with GeneCards custom track

Promoters for NSUN6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NSUN6 on UCSC Golden Path with GeneCards custom track

Genomic Location for NSUN6 Gene

18,545,207 bp from pter
18,659,309 bp from pter
114,103 bases
Minus strand

Genomic View for NSUN6 Gene

Genes around NSUN6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSUN6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSUN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSUN6 Gene

Proteins for NSUN6 Gene

  • Protein details for NSUN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative methyltransferase NSUN6
    Protein Accession:
    Secondary Accessions:
    • B0YJ54

    Protein attributes for NSUN6 Gene

    469 amino acids
    Molecular mass:
    51770 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NSUN6 Gene

Proteomics data for NSUN6 Gene at MOPED

Selected DME Specific Peptides for NSUN6 Gene

Post-translational modifications for NSUN6 Gene

  • Ubiquitination at Lys 419
  • Modification sites at PhosphoSitePlus

Other Protein References for NSUN6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NSUN6 Gene

Gene Families for NSUN6 Gene

Suggested Antigen Peptide Sequences for NSUN6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PUA domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  • Contains 1 PUA domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
genes like me logo Genes that share domains with NSUN6: view

Function for NSUN6 Gene

Molecular function for NSUN6 Gene

UniProtKB/Swiss-Prot Function:
May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

Enzyme Numbers (IUBMB) for NSUN6 Gene

Phenotypes for NSUN6 Gene

genes like me logo Genes that share phenotypes with NSUN6: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NSUN6 Gene

Localization for NSUN6 Gene

Subcellular locations from

Jensen Localization Image for NSUN6 Gene COMPARTMENTS Subcellular localization image for NSUN6 gene
Compartment Confidence
golgi apparatus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NSUN6 Gene

Pathways & Interactions for NSUN6 Gene

SuperPathways for NSUN6 Gene

No Data Available

Interacting Proteins for NSUN6 Gene

Gene Ontology (GO) - Biological Process for NSUN6 Gene


No data available for Pathways by source and SIGNOR curated interactions for NSUN6 Gene

Drugs & Compounds for NSUN6 Gene

(1) Drugs for NSUN6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with NSUN6: view

Transcripts for NSUN6 Gene

Unigene Clusters for NSUN6 Gene

NOP2/Sun domain family, member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NSUN6 Gene

No ASD Table

Relevant External Links for NSUN6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NSUN6 Gene

mRNA expression in normal human tissues for NSUN6 Gene

mRNA differential expression in normal tissues according to GTEx for NSUN6 Gene

This gene is overexpressed in Liver (x4.5).

Protein differential expression in normal tissues from HIPED for NSUN6 Gene

This gene is overexpressed in Breast (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NSUN6 Gene

SOURCE GeneReport for Unigene cluster for NSUN6 Gene Hs.396175

genes like me logo Genes that share expression patterns with NSUN6: view

Protein tissue co-expression partners for NSUN6 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NSUN6 Gene

Orthologs for NSUN6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NSUN6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NSUN6 35
  • 87.72 (n)
  • 89.22 (a)
-- 36
  • 88 (a)
(Canis familiaris)
Mammalia NSUN6 35
  • 88.84 (n)
  • 88.27 (a)
-- 36
  • 88 (a)
(Mus musculus)
Mammalia Nsun6 35
  • 81.73 (n)
  • 81.24 (a)
Nsun6 16
Nsun6 36
  • 80 (a)
(Pan troglodytes)
Mammalia NSUN6 35
  • 99.08 (n)
  • 98.72 (a)
NSUN6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nsun6 35
  • 80.95 (n)
  • 80.17 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
(Gallus gallus)
Aves NSUN6 35
  • 73.88 (n)
  • 73.66 (a)
-- 36
  • 73 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nsun6 35
  • 69.31 (n)
  • 68.88 (a)
Str.11935 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16793 35
(Danio rerio)
Actinopterygii LOC100149557 35
  • 59.46 (n)
  • 58.3 (a)
NSUN6 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11109 35
  • 49.37 (n)
  • 44.86 (a)
CG11109 36
  • 41 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP2 36
  • 18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06560 35
  • 51.11 (n)
  • 42.72 (a)
(Oryza sativa)
Liliopsida Os.21286 35
Os08g0365900 35
  • 52.82 (n)
  • 44.93 (a)
Species with no ortholog for NSUN6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSUN6 Gene

Gene Tree for NSUN6 (if available)
Gene Tree for NSUN6 (if available)

Paralogs for NSUN6 Gene

Paralogs for NSUN6 Gene

genes like me logo Genes that share paralogs with NSUN6: view

Variants for NSUN6 Gene

Sequence variations from dbSNP and Humsavar for NSUN6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1650 -- 18,613,873(-) GAGTT(C/T)TGTGG intron-variant
rs1623426 -- 18,643,701(-) ATGAA(A/G)GAGGG intron-variant
rs1624297 -- 18,643,609(-) ACTAG(A/C)CCCTT intron-variant
rs1630126 -- 18,649,527(-) cctca(G/T)cctcc intron-variant, upstream-variant-2KB
rs1687069 -- 18,641,665(+) cacca(C/G)atcca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NSUN6 Gene

Variant ID Type Subtype PubMed ID
esv34545 CNV Gain 17911159
dgv226e1 CNV Complex 17122850
nsv511455 CNV Loss 21212237
nsv466760 CNV Loss 19166990
esv25204 CNV Loss 19812545
esv2664218 CNV Deletion 23128226
dgv3e19 OTHER Inversion 19470904
nsv512150 CNV Loss 21212237
esv2446416 CNV Deletion 19546169
esv1520077 CNV Deletion 17803354
esv2733739 CNV Deletion 23290073
esv2667049 CNV Deletion 23128226
esv6083 OTHER Inversion 19470904
esv2294866 CNV Deletion 18987734
esv2661238 CNV Deletion 23128226
esv2670942 CNV Deletion 23128226
nsv466762 CNV Gain 19166990

Variation tolerance for NSUN6 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.77% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NSUN6 Gene

Disorders for NSUN6 Gene

Relevant External Links for NSUN6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NSUN6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSUN6 Gene

Publications for NSUN6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs. (PMID: 26160102) Haag S. … Bohnsack M.T. (RNA 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3
  5. An integrative method for scoring candidate genes from association studies: application to warfarin dosing. (PMID: 21044367) Tatonetti N.P. … Altman R.B. (BMC Bioinformatics 2010) 3

Products for NSUN6 Gene

Sources for NSUN6 Gene