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Aliases for NSUN6 Gene

Aliases for NSUN6 Gene

  • NOP2/Sun RNA Methyltransferase Family Member 6 2 3 5
  • NOL1/NOP2/Sun And PUA Domain-Containing Protein 1 3 4
  • NOL1/NOP2/Sun Domain Family, Member 6 2 3
  • NOP2/Sun Domain Family, Member 6 2 3
  • ARL5B Antisense RNA 1 2 3
  • NOPD1 3 4
  • Nucleolar Protein (NOL1/NOP2/Sun) And PUA Domains 1 3
  • NOL1/NOP2/Sun Domain Family Member 6 4
  • Putative Methyltransferase NSUN6 3
  • 4933414E04Rik 3
  • EC 2.1.1.52 61
  • EC 2.1.1.- 4
  • ARL5B-AS1 3
  • EC 2.1.1 61

External Ids for NSUN6 Gene

Previous HGNC Symbols for NSUN6 Gene

  • NOPD1
  • ARL5B-AS1

Previous GeneCards Identifiers for NSUN6 Gene

  • GC10M018874
  • GC10M018499

Summaries for NSUN6 Gene

GeneCards Summary for NSUN6 Gene

NSUN6 (NOP2/Sun RNA Methyltransferase Family Member 6) is a Protein Coding gene. Among its related pathways are tRNA processing and Gene Expression. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is NOP2.

UniProtKB/Swiss-Prot for NSUN6 Gene

  • May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSUN6 Gene

Genomics for NSUN6 Gene

Regulatory Elements for NSUN6 Gene

Enhancers for NSUN6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F018626 1.3 Ensembl ENCODE 44.5 +31.6 31631 1.6 ARID4B SIN3A FEZF1 DMAP1 ZNF2 GLIS2 EGR1 KLF7 MIXL1 EGR2 NSUN6 ENSG00000240291 ARL5B
GH10F018649 0.2 ENCODE 33.8 +8.3 8298 3.6 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000240291 NSUN6 ARL5B
GH10F018501 1 Ensembl 20.4 +157.8 157846 0.7 PKNOX1 MTA2 HLF TBX21 EP300 JUND IKZF1 FOS MLLT1 NSUN6 ENSG00000240291 PIR33686 GC10P018346
GH10F018609 0.8 Ensembl ENCODE 20.2 +48.2 48175 2.6 PKNOX1 ATF1 MLX ARID4B SIN3A FEZF1 ZNF48 YY1 FOS SP5 NSUN6 ARL5B ENSG00000240291
GH10F018607 1.5 FANTOM5 Ensembl ENCODE 20.2 +51.2 51236 1.7 JUND ATF3 NFIA JUN RAD21 ARL5B NSUN6 ENSG00000240291
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around NSUN6 on UCSC Golden Path with GeneCards custom track

Genomic Location for NSUN6 Gene

Chromosome:
10
Start:
18,545,207 bp from pter
End:
18,659,309 bp from pter
Size:
114,103 bases
Orientation:
Minus strand

Genomic View for NSUN6 Gene

Genes around NSUN6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSUN6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSUN6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSUN6 Gene

Proteins for NSUN6 Gene

  • Protein details for NSUN6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEA1-NSUN6_HUMAN
    Recommended name:
    Putative methyltransferase NSUN6
    Protein Accession:
    Q8TEA1
    Secondary Accessions:
    • B0YJ54

    Protein attributes for NSUN6 Gene

    Size:
    469 amino acids
    Molecular mass:
    51770 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NSUN6 Gene

Selected DME Specific Peptides for NSUN6 Gene

Post-translational modifications for NSUN6 Gene

  • Ubiquitination at Lys 419
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for NSUN6

Domains & Families for NSUN6 Gene

Gene Families for NSUN6 Gene

Suggested Antigen Peptide Sequences for NSUN6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TEA1

UniProtKB/Swiss-Prot:

NSUN6_HUMAN :
  • Contains 1 PUA domain.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
Domain:
  • Contains 1 PUA domain.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
genes like me logo Genes that share domains with NSUN6: view

Function for NSUN6 Gene

Molecular function for NSUN6 Gene

UniProtKB/Swiss-Prot Function:
May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

Enzyme Numbers (IUBMB) for NSUN6 Gene

Gene Ontology (GO) - Molecular Function for NSUN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000049 tRNA binding IDA 26160102
GO:0003723 RNA binding IEA --
GO:0008168 methyltransferase activity IEA --
GO:0008173 RNA methyltransferase activity IBA --
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity IBA --
genes like me logo Genes that share ontologies with NSUN6: view
genes like me logo Genes that share phenotypes with NSUN6: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NSUN6 Gene

Localization for NSUN6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NSUN6 Gene COMPARTMENTS Subcellular localization image for NSUN6 gene
Compartment Confidence
golgi apparatus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for NSUN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 26160102
genes like me logo Genes that share ontologies with NSUN6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NSUN6 Gene

Pathways & Interactions for NSUN6 Gene

genes like me logo Genes that share pathways with NSUN6: view

Pathways by source for NSUN6 Gene

Gene Ontology (GO) - Biological Process for NSUN6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001510 RNA methylation IBA --
GO:0030488 tRNA methylation IEA --
GO:0032259 methylation IEA --
genes like me logo Genes that share ontologies with NSUN6: view

No data available for SIGNOR curated interactions for NSUN6 Gene

Drugs & Compounds for NSUN6 Gene

(1) Drugs for NSUN6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with NSUN6: view

Transcripts for NSUN6 Gene

Unigene Clusters for NSUN6 Gene

NOP2/Sun domain family, member 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSUN6 Gene

No ASD Table

Relevant External Links for NSUN6 Gene

GeneLoc Exon Structure for
NSUN6
ECgene alternative splicing isoforms for
NSUN6

Expression for NSUN6 Gene

mRNA expression in normal human tissues for NSUN6 Gene

mRNA differential expression in normal tissues according to GTEx for NSUN6 Gene

This gene is overexpressed in Liver (x4.5).

Protein differential expression in normal tissues from HIPED for NSUN6 Gene

This gene is overexpressed in Breast (64.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NSUN6 Gene



Protein tissue co-expression partners for NSUN6 Gene

NURSA nuclear receptor signaling pathways regulating expression of NSUN6 Gene:

NSUN6

SOURCE GeneReport for Unigene cluster for NSUN6 Gene:

Hs.396175
genes like me logo Genes that share expression patterns with NSUN6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for NSUN6 Gene

Orthologs for NSUN6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NSUN6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NSUN6 34 35
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia NSUN6 34
  • 88.84 (n)
-- 35
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 88 (a)
OneToMany
NSUN6 34
  • 87.72 (n)
mouse
(Mus musculus)
Mammalia Nsun6 34 16 35
  • 81.73 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nsun6 34
  • 80.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves NSUN6 34
  • 73.88 (n)
-- 35
  • 73 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nsun6 34
  • 69.31 (n)
Str.11935 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16793 34
zebrafish
(Danio rerio)
Actinopterygii LOC100149557 34
  • 59.46 (n)
NSUN6 35
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11109 34 35
  • 49.37 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP2 35
  • 18 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06560 34
  • 51.11 (n)
rice
(Oryza sativa)
Liliopsida Os08g0365900 34
  • 52.82 (n)
Os.21286 34
Species where no ortholog for NSUN6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSUN6 Gene

ENSEMBL:
Gene Tree for NSUN6 (if available)
TreeFam:
Gene Tree for NSUN6 (if available)

Paralogs for NSUN6 Gene

Paralogs for NSUN6 Gene

genes like me logo Genes that share paralogs with NSUN6: view

Variants for NSUN6 Gene

Sequence variations from dbSNP and Humsavar for NSUN6 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs121917812 Pathogenic 18,539,345(+) CTCCT(C/T)AGCCC intron-variant, nc-transcript-variant, reference, missense
rs184280124 Likely pathogenic 18,539,333(+) GCACC(A/G)CTCTT intron-variant, nc-transcript-variant, reference, missense
rs560020203 Likely pathogenic 18,538,188(+) CTGTT(A/C/T)GATGT intron-variant, nc-transcript-variant, reference, synonymous-codon, missense
rs730880059 Likely pathogenic 18,539,383(+) GTCGC(A/G)GCCTC intron-variant, nc-transcript-variant, reference, missense
rs138423466 Likely benign 18,518,404(+) TCTCT(A/G)AAGGG intron-variant, nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for NSUN6 Gene

Variant ID Type Subtype PubMed ID
dgv370n106 CNV duplication 24896259
dgv3e19 OTHER inversion 19470904
dgv971n54 CNV gain 21841781
dgv972n54 CNV gain+loss 21841781
dgv973n54 CNV gain 21841781
dgv974n54 CNV gain 21841781
dgv975n54 CNV gain 21841781
dgv976n54 CNV gain+loss 21841781
dgv977n54 CNV loss 21841781
dgv978n54 CNV loss 21841781
dgv979n54 CNV gain 21841781
dgv980n54 CNV gain 21841781
dgv981n54 CNV loss 21841781
dgv982n54 CNV gain 21841781
dgv983n54 CNV loss 21841781
dgv984n54 CNV gain 21841781
esv1520077 CNV deletion 17803354
esv2294866 CNV deletion 18987734
esv2446416 CNV deletion 19546169
esv25204 CNV loss 19812545
esv2661238 CNV deletion 23128226
esv2664218 CNV deletion 23128226
esv2667049 CNV deletion 23128226
esv2670942 CNV deletion 23128226
esv2733739 CNV deletion 23290073
esv2759736 CNV gain 17122850
esv34545 CNV gain 17911159
esv3622509 CNV loss 21293372
esv3622510 CNV gain 21293372
esv3622511 CNV loss 21293372
esv3622512 CNV gain 21293372
esv3622513 CNV loss 21293372
esv6083 OTHER inversion 19470904
nsv1042073 CNV gain 25217958
nsv1069460 CNV deletion 25765185
nsv1077317 CNV duplication 25765185
nsv1120045 OTHER inversion 24896259
nsv1133974 CNV deletion 24896259
nsv1141167 CNV duplication 24896259
nsv1148802 CNV duplication 26484159
nsv1153075 CNV duplication 26484159
nsv466760 CNV loss 19166990
nsv466762 CNV gain 19166990
nsv511455 CNV loss 21212237
nsv512150 CNV loss 21212237
nsv550042 CNV gain 21841781
nsv550043 CNV gain 21841781
nsv550044 CNV loss 21841781
nsv550067 CNV loss 21841781
nsv550087 CNV gain+loss 21841781
nsv550098 CNV loss 21841781
nsv550100 CNV loss 21841781
nsv550109 CNV loss 21841781
nsv550118 CNV loss 21841781
nsv550121 CNV gain 21841781

Variation tolerance for NSUN6 Gene

Residual Variation Intolerance Score: 43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NSUN6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NSUN6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSUN6 Gene

Disorders for NSUN6 Gene

Relevant External Links for NSUN6

Genetic Association Database (GAD)
NSUN6
Human Genome Epidemiology (HuGE) Navigator
NSUN6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NSUN6

No disorders were found for NSUN6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSUN6 Gene

Publications for NSUN6 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs. (PMID: 26160102) Haag S. … Bohnsack M.T. (RNA 2015) 3 64

Products for NSUN6 Gene

Sources for NSUN6 Gene

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