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Aliases for NSUN3 Gene

Aliases for NSUN3 Gene

  • NOP2/Sun RNA Methyltransferase Family Member 3 2 3 5
  • NOL1/NOP2/Sun Domain Family, Member 3 2 3
  • NOL1/NOP2/Sun Domain Family Member 3 3 4
  • NOP2/Sun Domain Family, Member 3 2 3
  • NOL1/NOP2/Sun Domain Family 3 3
  • EC 2.1.1.- 4
  • EC 2.1.1 63
  • MSTP077 3
  • MST077 3

External Ids for NSUN3 Gene

Previous GeneCards Identifiers for NSUN3 Gene

  • GC03P095264
  • GC03P093781
  • GC03P091144

Summaries for NSUN3 Gene

GeneCards Summary for NSUN3 Gene

NSUN3 (NOP2/Sun RNA Methyltransferase Family Member 3) is a Protein Coding gene. GO annotations related to this gene include RNA binding and methyltransferase activity. An important paralog of this gene is NOP2.

UniProtKB/Swiss-Prot for NSUN3 Gene

  • May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSUN3 Gene

Genomics for NSUN3 Gene

Regulatory Elements for NSUN3 Gene

Promoters for NSUN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NSUN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for NSUN3 Gene

94,062,916 bp from pter
94,128,545 bp from pter
65,630 bases
Plus strand

Genomic View for NSUN3 Gene

Genes around NSUN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSUN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSUN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSUN3 Gene

Proteins for NSUN3 Gene

  • Protein details for NSUN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative methyltransferase NSUN3
    Protein Accession:
    Secondary Accessions:
    • Q6PG41
    • Q8IXG9
    • Q9H6M2

    Protein attributes for NSUN3 Gene

    340 amino acids
    Molecular mass:
    38244 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAN76512.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305}; Sequence=AAQ13600.1; Type=Frameshift; Positions=98; Evidence={ECO:0000305}; Sequence=BAB15234.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for NSUN3 Gene

Proteomics data for NSUN3 Gene at MOPED

Selected DME Specific Peptides for NSUN3 Gene

Post-translational modifications for NSUN3 Gene

  • Ubiquitination at Lys 67
  • Modification sites at PhosphoSitePlus

Other Protein References for NSUN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for NSUN3 Gene

Gene Families for NSUN3 Gene

Protein Domains for NSUN3 Gene

Suggested Antigen Peptide Sequences for NSUN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
genes like me logo Genes that share domains with NSUN3: view

Function for NSUN3 Gene

Molecular function for NSUN3 Gene

UniProtKB/Swiss-Prot Function:
May have S-adenosyl-L-methionine-dependent methyl-transferase activity.

Enzyme Numbers (IUBMB) for NSUN3 Gene

Phenotypes for NSUN3 Gene

GenomeRNAi human phenotypes for NSUN3:
genes like me logo Genes that share phenotypes with NSUN3: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NSUN3 Gene

Localization for NSUN3 Gene

Subcellular locations from

Jensen Localization Image for NSUN3 Gene COMPARTMENTS Subcellular localization image for NSUN3 gene
Compartment Confidence
mitochondrion 4
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NSUN3 Gene

Pathways & Interactions for NSUN3 Gene

SuperPathways for NSUN3 Gene

No Data Available

Interacting Proteins for NSUN3 Gene

Gene Ontology (GO) - Biological Process for NSUN3 Gene


No data available for Pathways by source and SIGNOR curated interactions for NSUN3 Gene

Drugs & Compounds for NSUN3 Gene

(1) Drugs for NSUN3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
genes like me logo Genes that share compounds with NSUN3: view

Transcripts for NSUN3 Gene

Unigene Clusters for NSUN3 Gene

NOP2/Sun domain family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NSUN3 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - -
SP2: -

Relevant External Links for NSUN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NSUN3 Gene

mRNA expression in normal human tissues for NSUN3 Gene

Protein differential expression in normal tissues from HIPED for NSUN3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.6), Cervix (23.2), and Serum (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NSUN3 Gene

SOURCE GeneReport for Unigene cluster for NSUN3 Gene Hs.448003

genes like me logo Genes that share expression patterns with NSUN3: view

Protein tissue co-expression partners for NSUN3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for NSUN3 Gene

Orthologs for NSUN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NSUN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NSUN3 35
  • 91.2 (n)
  • 91.69 (a)
NSUN3 36
  • 91 (a)
(Canis familiaris)
Mammalia NSUN3 35
  • 88.82 (n)
  • 88.92 (a)
NSUN3 36
  • 89 (a)
(Mus musculus)
Mammalia Nsun3 35
  • 84.17 (n)
  • 82.6 (a)
Nsun3 16
Nsun3 36
  • 80 (a)
(Pan troglodytes)
Mammalia NSUN3 35
  • 99.41 (n)
  • 99.12 (a)
NSUN3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nsun3 35
  • 82.16 (n)
  • 80 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
-- 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia NSUN3 36
  • 76 (a)
(Gallus gallus)
Aves NSUN3 35
  • 68.59 (n)
  • 67.88 (a)
NSUN3 36
  • 62 (a)
(Anolis carolinensis)
Reptilia NSUN3 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nsun3 35
  • 66.04 (n)
  • 64.69 (a)
(Danio rerio)
Actinopterygii nsun3 35
  • 56.6 (n)
  • 52.57 (a)
nsun3 36
  • 46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP2 36
  • 12 (a)
Species with no ortholog for NSUN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSUN3 Gene

Gene Tree for NSUN3 (if available)
Gene Tree for NSUN3 (if available)

Paralogs for NSUN3 Gene

Paralogs for NSUN3 Gene

(1) SIMAP similar genes for NSUN3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with NSUN3: view

Variants for NSUN3 Gene

Sequence variations from dbSNP and Humsavar for NSUN3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17854922 - 94,126,351(+) AATAG(C/T)AAGGA reference, missense
rs2965 -- 94,099,622(-) GGACT(A/C)GGAAT intron-variant
rs921727 -- 94,114,664(+) TTACA(A/C)GGATG intron-variant
rs921728 -- 94,114,731(+) ATAGC(A/G)CCAAA intron-variant
rs930815 -- 94,119,717(+) CTTTG(A/C)ATACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NSUN3 Gene

Variant ID Type Subtype PubMed ID
nsv877162 CNV Gain 21882294
nsv877163 CNV Gain 21882294
esv2678302 CNV Deletion 23128226

Variation tolerance for NSUN3 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NSUN3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSUN3 Gene

Disorders for NSUN3 Gene

Relevant External Links for NSUN3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NSUN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSUN3 Gene

Publications for NSUN3 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese. (PMID: 24165912) He J. … Gu D. (Circ Cardiovasc Genet 2013) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for NSUN3 Gene

Sources for NSUN3 Gene

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