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Aliases for NSRP1 Gene

Aliases for NSRP1 Gene

  • Nuclear Speckle Splicing Regulatory Protein 1 2 3 5
  • Coiled-Coil Domain-Containing Protein 55 3 4
  • Nuclear Speckle-Related Protein 70 3 4
  • Coiled-Coil Domain Containing 55 2 3
  • CCDC55 3 4
  • NSrp70 3 4
  • HSPC095 3

External Ids for NSRP1 Gene

Previous HGNC Symbols for NSRP1 Gene

  • CCDC55

Previous GeneCards Identifiers for NSRP1 Gene

  • GC17P028445
  • GC17P028442

Summaries for NSRP1 Gene

GeneCards Summary for NSRP1 Gene

NSRP1 (Nuclear Speckle Splicing Regulatory Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include mRNA binding.

UniProtKB/Swiss-Prot for NSRP1 Gene

  • RNA-binding protein that mediates pre-mRNA alternative splicing regulation.

Gene Wiki entry for NSRP1 Gene

Additional gene information for NSRP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSRP1 Gene

Genomics for NSRP1 Gene

GeneHancer (GH) Regulatory Elements for NSRP1 Gene

Promoters and enhancers for NSRP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I030116 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.9 1922 2.6 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ENSG00000265394 ENSG00000266919 GC17P030118 PIR49703 MIR423 NSRP1 MIR3184 NUFIP2 CORO6 ENSG00000264456
GH17I030138 Promoter 0.7 EPDnew 561.9 +23.4 23360 0.1 ZNF362 ZNF18 NSRP1 ENSG00000252112 RNU6-1267P BLMH TMIGD1 ENSG00000266987 ENSG00000265739
GH17I030114 Enhancer 0.4 ENCODE 550.8 -1.1 -1086 0.1 JUNB BATF RUNX3 NSRP1 BLMH RNU6-1267P ENSG00000265394 GC17M030077
GH17I030905 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.9 +791.0 790956 2.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 TEFM GC17P030905 GC17P030907 ADAP2 UTP6 SUZ12P1 ATAD5 GOSR1 NF1 ENSG00000264456
GH17I029290 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.5 -822.3 -822255 4.8 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC NUFIP2 ENSG00000264577 SUPT6H TMEM199 LOC101927018 PHF12 RPL23A ENSG00000264044 RAB34 MYO18A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NSRP1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NSRP1 Gene

Genomic Locations for NSRP1 Gene
chr17:30,115,521-30,186,475
(GRCh38/hg38)
Size:
70,955 bases
Orientation:
Plus strand
chr17:28,442,539-28,513,493
(GRCh37/hg19)

Genomic View for NSRP1 Gene

Genes around NSRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSRP1 Gene

Proteins for NSRP1 Gene

  • Protein details for NSRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0G5-NSRP1_HUMAN
    Recommended name:
    Nuclear speckle splicing regulatory protein 1
    Protein Accession:
    Q9H0G5
    Secondary Accessions:
    • Q6FI71

    Protein attributes for NSRP1 Gene

    Size:
    558 amino acids
    Molecular mass:
    66390 Da
    Quaternary structure:
    • Interacts (via C-terminus) with SRSF1. Interacts (via C-terminus) with SRSF2.

neXtProt entry for NSRP1 Gene

Post-translational modifications for NSRP1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NSRP1 Gene

Domains & Families for NSRP1 Gene

Gene Families for NSRP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NSRP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NSRP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H0G5

UniProtKB/Swiss-Prot:

NSRP1_HUMAN :
  • Belongs to the NSRP1 family.
Family:
  • Belongs to the NSRP1 family.
genes like me logo Genes that share domains with NSRP1: view

Function for NSRP1 Gene

Molecular function for NSRP1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in motile T-cells.

Phenotypes From GWAS Catalog for NSRP1 Gene

Gene Ontology (GO) - Molecular Function for NSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA,IEA 22658674
GO:0003729 mRNA binding IDA 21296756
GO:0005515 protein binding IPI 21296756
genes like me logo Genes that share ontologies with NSRP1: view
genes like me logo Genes that share phenotypes with NSRP1: view

Animal Model Products

miRNA for NSRP1 Gene

miRTarBase miRNAs that target NSRP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NSRP1 Gene

Localization for NSRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSRP1 Gene

Nucleus. Nucleus speckle. Note=Colocalizes with splicing factors SRSF1 and SRSF2 in speckles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NSRP1 gene
Compartment Confidence
nucleus 5
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21296756
GO:0005654 nucleoplasm IDA --
GO:0016607 nuclear speck IDA,IEA 21296756
GO:0030529 intracellular ribonucleoprotein complex IDA 21296756
genes like me logo Genes that share ontologies with NSRP1: view

Pathways & Interactions for NSRP1 Gene

SuperPathways for NSRP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 21296756
GO:0006397 mRNA processing IEA --
GO:0006913 nucleocytoplasmic transport IDA 21296756
GO:0008380 RNA splicing IEA --
GO:0032502 developmental process IMP 21296756
genes like me logo Genes that share ontologies with NSRP1: view

No data available for Pathways by source and SIGNOR curated interactions for NSRP1 Gene

Drugs & Compounds for NSRP1 Gene

No Compound Related Data Available

Transcripts for NSRP1 Gene

Unigene Clusters for NSRP1 Gene

Nuclear speckle splicing regulatory protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSRP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2:

Relevant External Links for NSRP1 Gene

GeneLoc Exon Structure for
NSRP1
ECgene alternative splicing isoforms for
NSRP1

Expression for NSRP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NSRP1 Gene

Protein differential expression in normal tissues from HIPED for NSRP1 Gene

This gene is overexpressed in Adrenal (33.3) and Peripheral blood mononuclear cells (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NSRP1 Gene



Protein tissue co-expression partners for NSRP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NSRP1 Gene:

NSRP1

SOURCE GeneReport for Unigene cluster for NSRP1 Gene:

Hs.462663

mRNA Expression by UniProt/SwissProt for NSRP1 Gene:

Q9H0G5-NSRP1_HUMAN
Tissue specificity: Expressed in dendritic cells, T-cells, B-cells and natural killer cells. Expressed in secondary lymphoid organs such as spleen and mesenteric, axillary and brachial lymph nodes.

Evidence on tissue expression from TISSUES for NSRP1 Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Heart(2)
genes like me logo Genes that share expression patterns with NSRP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NSRP1 Gene

Orthologs for NSRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NSRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NSRP1 33
  • 99.58 (n)
CCDC55 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NSRP1 33 34
  • 88.71 (n)
cow
(Bos Taurus)
Mammalia NSRP1 33 34
  • 86.93 (n)
rat
(Rattus norvegicus)
Mammalia Nsrp1 33
  • 82.66 (n)
mouse
(Mus musculus)
Mammalia Ccdc55 33 34
  • 81.02 (n)
Nsrp1 16
platypus
(Ornithorhynchus anatinus)
Mammalia NSRP1 34
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NSRP1 34
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves NSRP1 33 34
  • 64.46 (n)
lizard
(Anolis carolinensis)
Reptilia NSRP1 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nsrp1 33
  • 60.16 (n)
zebrafish
(Danio rerio)
Actinopterygii nsrp1 33 34
  • 54.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15747 34
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ccdc-55 34
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4847 34
  • 49 (a)
OneToOne
Species where no ortholog for NSRP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NSRP1 Gene

ENSEMBL:
Gene Tree for NSRP1 (if available)
TreeFam:
Gene Tree for NSRP1 (if available)

Paralogs for NSRP1 Gene

Pseudogenes.org Pseudogenes for NSRP1 Gene

genes like me logo Genes that share paralogs with NSRP1: view

No data available for Paralogs for NSRP1 Gene

Variants for NSRP1 Gene

Sequence variations from dbSNP and Humsavar for NSRP1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000042731 -- 30,183,669(+) A/G intron_variant
rs1000152164 -- 30,124,543(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000162723 -- 30,166,933(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000183706 -- 30,124,170(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000221662 -- 30,116,946(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NSRP1 Gene

Variant ID Type Subtype PubMed ID
dgv5518n54 CNV loss 21841781
esv2373242 CNV deletion 18987734
esv2458896 CNV deletion 19546169
esv2606765 CNV deletion 19546169
esv3303973 CNV mobile element insertion 20981092
esv3344007 CNV insertion 20981092
nsv112136 CNV deletion 16902084
nsv513467 CNV insertion 21212237

Variation tolerance for NSRP1 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NSRP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NSRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSRP1 Gene

Disorders for NSRP1 Gene

Additional Disease Information for NSRP1

No disorders were found for NSRP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSRP1 Gene

Publications for NSRP1 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo. (PMID: 21296756) Kim YD … Jun CD (Nucleic acids research 2011) 3 4 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for NSRP1 Gene

Sources for NSRP1 Gene

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