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Aliases for NSRP1 Gene

Aliases for NSRP1 Gene

  • Nuclear Speckle Splicing Regulatory Protein 1 2 3 5
  • Coiled-Coil Domain-Containing Protein 55 3 4
  • Nuclear Speckle-Related Protein 70 3 4
  • Coiled-Coil Domain Containing 55 2 3
  • CCDC55 3 4
  • NSrp70 3 4
  • HSPC095 3

External Ids for NSRP1 Gene

Previous HGNC Symbols for NSRP1 Gene

  • CCDC55

Previous GeneCards Identifiers for NSRP1 Gene

  • GC17P028445
  • GC17P028442

Summaries for NSRP1 Gene

GeneCards Summary for NSRP1 Gene

NSRP1 (Nuclear Speckle Splicing Regulatory Protein 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and mRNA binding.

UniProtKB/Swiss-Prot for NSRP1 Gene

  • RNA-binding protein that mediates pre-mRNA alternative splicing regulation.

Gene Wiki entry for NSRP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSRP1 Gene

Genomics for NSRP1 Gene

Regulatory Elements for NSRP1 Gene

Enhancers for NSRP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NSRP1 on UCSC Golden Path with GeneCards custom track

Promoters for NSRP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NSRP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NSRP1 Gene

30,115,521 bp from pter
30,186,475 bp from pter
70,955 bases
Plus strand

Genomic View for NSRP1 Gene

Genes around NSRP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSRP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSRP1 Gene

Proteins for NSRP1 Gene

  • Protein details for NSRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear speckle splicing regulatory protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6FI71

    Protein attributes for NSRP1 Gene

    558 amino acids
    Molecular mass:
    66390 Da
    Quaternary structure:
    • Interacts (via C-terminus) with SRSF1. Interacts (via C-terminus) with SRSF2.

neXtProt entry for NSRP1 Gene

Proteomics data for NSRP1 Gene at MOPED

Post-translational modifications for NSRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NSRP1 Gene

Domains & Families for NSRP1 Gene

Protein Domains for NSRP1 Gene


Suggested Antigen Peptide Sequences for NSRP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NSRP1 family.
  • Belongs to the NSRP1 family.
genes like me logo Genes that share domains with NSRP1: view

No data available for Gene Families for NSRP1 Gene

Function for NSRP1 Gene

Molecular function for NSRP1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in motile T-cells.
genes like me logo Genes that share phenotypes with NSRP1: view

Animal Model Products

CRISPR Products

miRNA for NSRP1 Gene

miRTarBase miRNAs that target NSRP1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NSRP1 Gene

Localization for NSRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSRP1 Gene

Nucleus. Nucleus speckle. Note=Colocalizes with splicing factors SRSF1 and SRSF2 in speckles.

Subcellular locations from

Jensen Localization Image for NSRP1 Gene COMPARTMENTS Subcellular localization image for NSRP1 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for NSRP1 Gene

Pathways & Interactions for NSRP1 Gene

SuperPathways for NSRP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032502 developmental process IMP 21296756
genes like me logo Genes that share ontologies with NSRP1: view

No data available for Pathways by source and SIGNOR curated interactions for NSRP1 Gene

Drugs & Compounds for NSRP1 Gene

No Compound Related Data Available

Transcripts for NSRP1 Gene

Unigene Clusters for NSRP1 Gene

Nuclear speckle splicing regulatory protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NSRP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -

Relevant External Links for NSRP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NSRP1 Gene

mRNA expression in normal human tissues for NSRP1 Gene

Protein differential expression in normal tissues from HIPED for NSRP1 Gene

This gene is overexpressed in Adrenal (33.3) and Peripheral blood mononuclear cells (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NSRP1 Gene

SOURCE GeneReport for Unigene cluster for NSRP1 Gene Hs.462663

mRNA Expression by UniProt/SwissProt for NSRP1 Gene

Tissue specificity: Expressed in dendritic cells, T-cells, B-cells and natural killer cells. Expressed in secondary lymphoid organs such as spleen and mesenteric, axillary and brachial lymph nodes.
genes like me logo Genes that share expression patterns with NSRP1: view

Protein tissue co-expression partners for NSRP1 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for NSRP1 Gene

Orthologs for NSRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NSRP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NSRP1 35
  • 86.93 (n)
  • 82.01 (a)
NSRP1 36
  • 82 (a)
(Canis familiaris)
Mammalia NSRP1 35
  • 88.71 (n)
  • 84.34 (a)
NSRP1 36
  • 84 (a)
(Mus musculus)
Mammalia Ccdc55 35
  • 81.02 (n)
  • 75.6 (a)
Nsrp1 16
Ccdc55 36
  • 75 (a)
(Pan troglodytes)
Mammalia NSRP1 35
  • 99.58 (n)
  • 99.1 (a)
CCDC55 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Nsrp1 35
  • 82.66 (n)
  • 74.73 (a)
(Monodelphis domestica)
Mammalia NSRP1 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia NSRP1 36
  • 62 (a)
(Gallus gallus)
Aves NSRP1 35
  • 64.46 (n)
  • 57.77 (a)
NSRP1 36
  • 54 (a)
(Anolis carolinensis)
Reptilia NSRP1 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nsrp1 35
  • 60.16 (n)
  • 52.47 (a)
(Danio rerio)
Actinopterygii nsrp1 35
  • 54.89 (n)
  • 47.99 (a)
nsrp1 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15747 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea ccdc-55 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4847 36
  • 49 (a)
Species with no ortholog for NSRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NSRP1 Gene

Gene Tree for NSRP1 (if available)
Gene Tree for NSRP1 (if available)

Paralogs for NSRP1 Gene Pseudogenes for NSRP1 Gene

genes like me logo Genes that share paralogs with NSRP1: view

No data available for Paralogs for NSRP1 Gene

Variants for NSRP1 Gene

Sequence variations from dbSNP and Humsavar for NSRP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs11544945 - 30,178,156(+) AAAAA(A/C)GGAGG reference, missense
rs1128156 -- 30,186,158(+) TGTTC(A/G)AGAGG utr-variant-3-prime
rs1825880 -- 30,181,616(-) AAAAA(A/C)AAAAA intron-variant
rs1979572 -- 30,184,960(-) TTCTG(C/T)TGGTG reference, synonymous-codon
rs1532042 -- 30,177,371(-) TAAAG(A/C)GATGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NSRP1 Gene

Variant ID Type Subtype PubMed ID
nsv908042 CNV Loss 21882294
esv2458896 CNV Deletion 19546169
esv2373242 CNV Deletion 18987734
esv268252 CNV Insertion 20981092
nsv908043 CNV Loss 21882294
nsv112136 CNV Loss 16902084
nsv513467 CNV Insertion 21212237
esv2606765 CNV Deletion 19546169

Variation tolerance for NSRP1 Gene

Residual Variation Intolerance Score: 62.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NSRP1 Gene

Disorders for NSRP1 Gene

Relevant External Links for NSRP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for NSRP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSRP1 Gene

Publications for NSRP1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. (PMID: 26527279) Campos E.I. … Reinberg D. (Mol. Cell 2015) 3
  4. Aberrant proteomic expression of NSRP70 and its clinical implications and connection to the transcriptional level in adult acute leukemia. (PMID: 25176346) Choi D.B. … Park D.S. (Leuk. Res. 2014) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for NSRP1 Gene

Sources for NSRP1 Gene