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Aliases for NSRP1 Gene

Aliases for NSRP1 Gene

  • Nuclear Speckle Splicing Regulatory Protein 1 2 3
  • Coiled-Coil Domain-Containing Protein 55 3 4
  • Nuclear Speckle-Related Protein 70 3 4
  • Coiled-Coil Domain Containing 55 2 3
  • CCDC55 3 4
  • NSrp70 3 4
  • HSPC095 3

External Ids for NSRP1 Gene

Previous HGNC Symbols for NSRP1 Gene

  • CCDC55

Previous GeneCards Identifiers for NSRP1 Gene

  • GC17P028445
  • GC17P028442

Summaries for NSRP1 Gene

GeneCards Summary for NSRP1 Gene

NSRP1 (Nuclear Speckle Splicing Regulatory Protein 1) is a Protein Coding gene. GO annotations related to this gene include mRNA binding.

UniProtKB/Swiss-Prot for NSRP1 Gene

  • RNA-binding protein that mediates pre-mRNA alternative splicing regulation.

Gene Wiki entry for NSRP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSRP1 Gene

Genomics for NSRP1 Gene

Genomic Location for NSRP1 Gene

30,115,521 bp from pter
30,186,475 bp from pter
70,955 bases
Plus strand

Genomic View for NSRP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NSRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSRP1 Gene

No data available for Regulatory Elements for NSRP1 Gene

Proteins for NSRP1 Gene

  • Protein details for NSRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nuclear speckle splicing regulatory protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6FI71

    Protein attributes for NSRP1 Gene

    558 amino acids
    Molecular mass:
    66390 Da
    Quaternary structure:
    • Interacts (via C-terminus) with SRSF1. Interacts (via C-terminus) with SRSF2.

neXtProt entry for NSRP1 Gene

Proteomics data for NSRP1 Gene at MOPED

Post-translational modifications for NSRP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NSRP1 Gene

Domains for NSRP1 Gene

Protein Domains for NSRP1 Gene


Suggested Antigen Peptide Sequences for NSRP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H0G5
  • Belongs to the NSRP1 family.
genes like me logo Genes that share domains with NSRP1: view

No data available for Gene Families for NSRP1 Gene

Function for NSRP1 Gene

Molecular function for NSRP1 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein that mediates pre-mRNA alternative splicing regulation.
UniProtKB/Swiss-Prot Induction: Up-regulated in motile T-cells.

Gene Ontology (GO) - Molecular Function for NSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IDA 21296756
GO:0005515 protein binding IPI 21296756
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with NSRP1: view

Phenotypes for NSRP1 Gene

MGI mutant phenotypes for NSRP1:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with NSRP1: view

Animal Model Products

CRISPR Products

miRNA for NSRP1 Gene

miRTarBase miRNAs that target NSRP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NSRP1 Gene

Localization for NSRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSRP1 Gene

Nucleus. Nucleus speckle. Note=Colocalizes with splicing factors SRSF1 and SRSF2 in speckles.

Gene Ontology (GO) - Cellular Components for NSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21296756
GO:0016607 nuclear speck IDA --
GO:0030529 ribonucleoprotein complex IDA 21296756
genes like me logo Genes that share ontologies with NSRP1: view

No data available for Subcellular locations from COMPARTMENTS for NSRP1 Gene

Pathways for NSRP1 Gene

SuperPathways for NSRP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NSRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 21296756
GO:0006397 mRNA processing IEA --
GO:0006913 nucleocytoplasmic transport IDA 21296756
GO:0008380 RNA splicing IEA --
GO:0032502 developmental process IMP 21296756
genes like me logo Genes that share ontologies with NSRP1: view

No data available for Pathways by source for NSRP1 Gene

Transcripts for NSRP1 Gene

Unigene Clusters for NSRP1 Gene

Nuclear speckle splicing regulatory protein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NSRP1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for NSRP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NSRP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -

Relevant External Links for NSRP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NSRP1 Gene

mRNA expression in normal human tissues for NSRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for NSRP1 Gene

SOURCE GeneReport for Unigene cluster for NSRP1 Gene Hs.462663

mRNA Expression by UniProt/SwissProt for NSRP1 Gene

Tissue specificity: Expressed in dendritic cells, T-cells, B-cells and natural killer cells. Expressed in secondary lymphoid organs such as spleen and mesenteric, axillary and brachial lymph nodes.
genes like me logo Genes that share expressions with NSRP1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for NSRP1 Gene

Orthologs for NSRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NSRP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC55 36
  • 99 (a)
NSRP1 35
  • 99.58 (n)
  • 99.1 (a)
(Bos Taurus)
Mammalia NSRP1 35
  • 86.93 (n)
  • 82.01 (a)
NSRP1 36
  • 82 (a)
(Canis familiaris)
Mammalia NSRP1 35
  • 88.71 (n)
  • 84.34 (a)
NSRP1 36
  • 84 (a)
(Mus musculus)
Mammalia Ccdc55 35
  • 81.02 (n)
  • 75.6 (a)
Ccdc55 16
Ccdc55 36
  • 75 (a)
(Monodelphis domestica)
Mammalia NSRP1 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia NSRP1 36
  • 62 (a)
(Rattus norvegicus)
Mammalia Nsrp1 35
  • 82.66 (n)
  • 74.73 (a)
(Gallus gallus)
Aves NSRP1 35
  • 64.46 (n)
  • 57.77 (a)
NSRP1 36
  • 54 (a)
(Anolis carolinensis)
Reptilia NSRP1 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nsrp1 35
  • 60.16 (n)
  • 52.47 (a)
(Danio rerio)
Actinopterygii nsrp1 35
  • 54.89 (n)
  • 47.99 (a)
nsrp1 36
  • 41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15747 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea ccdc-55 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4847 36
  • 49 (a)
Species with no ortholog for NSRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NSRP1 Gene

Gene Tree for NSRP1 (if available)
Gene Tree for NSRP1 (if available)

Paralogs for NSRP1 Gene Pseudogenes for NSRP1 Gene

genes like me logo Genes that share paralogs with NSRP1: view

No data available for Paralogs for NSRP1 Gene

Variants for NSRP1 Gene

Sequence variations from dbSNP and Humsavar for NSRP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1128156 -- 30,186,158(+) TGTTC(A/G)AGAGG utr-variant-3-prime
rs1532042 -- 30,177,371(-) TAAAG(A/C)GATGG intron-variant
rs1825880 -- 30,181,616(-) AAAAA(A/C)AAAAA intron-variant
rs1979572 -- 30,184,960(-) TTCTG(C/T)TGGTG synonymous-codon, reference
rs2054846 -- 30,180,675(-) CAGAG(C/T)TCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NSRP1 Gene

Variant ID Type Subtype PubMed ID
nsv908042 CNV Loss 21882294
esv2458896 CNV Deletion 19546169
esv2373242 CNV Deletion 18987734
esv268252 CNV Insertion 20981092
nsv908043 CNV Loss 21882294
nsv112136 CNV Loss 16902084
nsv513467 CNV Insertion 21212237
esv2606765 CNV Deletion 19546169

Relevant External Links for NSRP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSRP1 Gene

Disorders for NSRP1 Gene

No disorders were found for NSRP1 Gene.

No data available for UniProtKB/Swiss-Prot for NSRP1 Gene

Publications for NSRP1 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo. (PMID: 21296756) Kim Y.D. … Jun C.D. (Nucleic Acids Res. 2011) 3 4

Products for NSRP1 Gene

Sources for NSRP1 Gene

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