Aliases for NSMCE4A Gene
External Ids for NSMCE4A Gene
Previous HGNC Symbols for NSMCE4A Gene
Previous GeneCards Identifiers for NSMCE4A Gene
GeneCards Summary for NSMCE4A Gene
NSMCE4A (NSE4 Homolog A, SMC5-SMC6 Complex Component) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and SUMOylation. An important paralog of this gene is EID3.
UniProtKB/Swiss-Prot for NSMCE4A Gene
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus.