Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



NSMCE4A Gene

protein-coding   GIFtS: 51
GCID: GC10M123716

Non-SMC Element 4 Homolog A (S. Cerevisiae)

(Previous name: chromosome 10 open reading frame 86)
(Previous symbol: C10orf86)
  Search for NSMCE4A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Non-SMC Element 4 Homolog A (S. Cerevisiae)1 2     Chromosome 10 Open Reading Frame 861
C10orf861 2 3     Non-Structural Maintenance Of Chromosomes Element 4 Homolog A2
NS4EA2 3     Non-SMC Element 4 Homolog A3
NSE4A2 5     

External Ids:    HGNC: 259351   Entrez Gene: 547802   Ensembl: ENSG000001076727   OMIM: 6129875   UniProtKB: Q9NXX63   
ORGUL members:         

Export aliases for NSMCE4A gene to outside databases

Previous GC identifers: GC10M123709 GC10M117347


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for NSMCE4A Gene:
NSMCE4A (non-SMC element 4 homolog A (S. cerevisiae)) is a protein-coding gene. An important paralog of this gene is EID3.

UniProtKB/Swiss-Prot: NSE4A_HUMAN, Q9NXX6
Function: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous
recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3
cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in
ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome)
components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is
involved in positive regulation of response to DNA damage stimulus

Gene Wiki entry for NSMCE4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NSMCE4A gene promoter:
         E2F-3a   E2F-4   E2F-5   Pax-6   E2F-2   HNF-1A   PPAR-alpha   E2F-1   E2F   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNSMCE4A promoter sequence
   Search Chromatin IP Primers for NSMCE4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NSMCE4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q26.13   Ensembl cytogenetic band:  10q26.13   HGNC cytogenetic band: 10q26.13

NSMCE4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NSMCE4A gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M123716:  view genomic region     (about GC identifiers)

Start:
123,716,603 bp from pter      End:
123,734,743 bp from pter
Size:
18,141 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NSE4A_HUMAN, Q9NXX6 (See protein sequence)
Recommended Name: Non-structural maintenance of chromosomes element 4 homolog A  
Size: 385 amino acids; 44301 Da
Subunit: Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3
and NDNL2. NSMCE1, NSMCE4A or EID3 and NDNL2 probably form a subcomplex that bridges the head domains of the
SMC5:SMC6 heterodimer
Secondary accessions: Q5SQQ5 Q6P673 Q8WY66 Q9BS90
Alternative splicing: 2 isoforms:  Q9NXX6-1   Q9NXX6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for NSMCE4A: NX_Q9NXX6

Explore proteomics data for NSMCE4A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys238
  • Modification sites at PhosphoSitePlus

  • See NSMCE4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161337.1  NP_060085.2  

    ENSEMBL proteins: 
     ENSP00000358019   ENSP00000358013   ENSP00000445856  

    NSMCE4A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for NSMCE4A
    OriGene Protein Over-expression Lysate for NSMCE4A
    OriGene MassSpec for NSMCE4A
    OriGene Custom Protein Services for NSMCE4A
    GenScript Custom Purified and Recombinant Proteins Services for NSMCE4A
    Novus Biologicals NSMCE4A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NSMCE4A

    NSMCE4A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for NSMCE4A
    Novus Biologicals NSMCE4A Antibody
    Abcam antibodies for NSMCE4A
    Cloud-Clone Corp. Antibodies for NSMCE4A
    ThermoFisher Antibodies for NSMCE4A
    LSBio Antibodies in human, mouse, rat for NSMCE4A

    NSMCE4A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for NSMCE4A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NSMCE4A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for NSMCE4A
    Cloud-Clone Corp. CLIAs for NSMCE4A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR014854 Nse4_C
     IPR027786 Nse4

    Graphical View of Domain Structure for InterPro Entry Q9NXX6

    ProtoNet protein and cluster: Q9NXX6

    UniProtKB/Swiss-Prot: NSE4A_HUMAN, Q9NXX6
    Similarity: Belongs to the NSE4 family


    NSMCE4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NSE4A_HUMAN, Q9NXX6
    Function: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous
    recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3
    cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in
    ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome)
    components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Is
    involved in positive regulation of response to DNA damage stimulus

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18086888
         
    NSMCE4A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NSMCE4A:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NSMCE4A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NSMCE4A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NSMCE4A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for NSMCE4A

    miRNA
    Products:
        
    miRTarBase miRNAs that target NSMCE4A:
    hsa-let-7b-5p (MIRT032268)

    Block miRNA regulation of human, mouse, rat NSMCE4A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NSMCE4A (see all 9):
    hsa-miR-548am hsa-miR-548d-3p hsa-miR-338-5p hsa-miR-548x hsa-miR-487a hsa-miR-485-3p hsa-miR-222 hsa-miR-221
    SwitchGear 3'UTR luciferase reporter plasmidNSMCE4A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for NSMCE4A
    Predesigned siRNA for gene silencing in human, mouse, rat NSMCE4A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NSMCE4A

    Clone
    Products:
         
    OriGene clones in human, mouse for NSMCE4A (see all 11)
    OriGene ORF clones in mouse, rat for NSMCE4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NSMCE4A (NM_017615)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NSMCE4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSMCE4A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NSMCE4A
    Browse ESI BIO Cell Lines and PureStem Progenitors for NSMCE4A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSMCE4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NSE4A_HUMAN, Q9NXX6: Nucleus. Chromosome, telomere (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0030915Smc5-Smc6 complex IDA18086888

    NSMCE4A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NSMCE4A
    Interactions:

        Search GeneGlobe Interaction Network for NSMCE4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NSMCE4A (Q9NXX61, 3 ENSP000003580194) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NDNL2Q96MG71, ENSP000003306944EBI-2557393,EBI-2557356 STRING: ENSP00000330694
    APPBP2Q926243I2D: score=1 
    SMC5ENSP000003549574STRING: ENSP00000354957
    MAGEA1ENSP000003490854STRING: ENSP00000349085
    MAGED4BENSP000003353854STRING: ENSP00000335385
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:2001022positive regulation of response to DNA damage stimulus IMP18086888

    NSMCE4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NSMCE4A (NSE4A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for NSMCE4A gene (2 alternative transcripts): 
    NM_001167865.1  NM_017615.2  

    Unigene Cluster for NSMCE4A:

    Non-SMC element 4 homolog A (S. cerevisiae)
    Hs.258798  [show with all ESTs]
    Unigene Representative Sequence: AF258584
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369023(uc001lfs.3 uc009xzv.3) ENST00000459911 ENST00000477289
    ENST00000489266 ENST00000468209 ENST00000483541 ENST00000369017(uc001lfu.2)
    ENST00000464321 ENST00000481320 ENST00000472431 ENST00000465189 ENST00000538652(uc010qtu.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat NSMCE4A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate NSMCE4A (see all 9):
    hsa-miR-548am hsa-miR-548d-3p hsa-miR-338-5p hsa-miR-548x hsa-miR-487a hsa-miR-485-3p hsa-miR-222 hsa-miR-221
    SwitchGear 3'UTR luciferase reporter plasmidNSMCE4A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for NSMCE4A
    Predesigned siRNA for gene silencing in human, mouse, rat NSMCE4A
    Clone
    Products:
         
    OriGene clones in human, mouse for NSMCE4A (see all 11)
    OriGene ORF clones in mouse, rat for NSMCE4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): NSMCE4A (NM_017615)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NSMCE4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSMCE4A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for NSMCE4A
    OriGene qSTAR qPCR primer pairs in human, mouse for NSMCE4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NSMCE4A
      QuantiTect SYBR Green Assays in human, mouse, rat NSMCE4A
      QuantiFast Probe-based Assays in human, mouse, rat NSMCE4A

    Additional mRNA sequence: 

    AF258584.1 AK000010.1 AK056579.1 AK222487.1 AK301658.1 AK308687.1 BC005212.1 BC062427.1 

    15 DOTS entries:

    DT.216493  DT.95172039  DT.40307357  DT.100820595  DT.97776019  DT.92428116  DT.97843547  DT.121225632 
    DT.100820596  DT.216495  DT.100820594  DT.92428121  DT.95172033  DT.95172044  DT.97843548 

    Selected AceView cDNA sequences (see all 173):

    CK825869 BF195617 AI337530 CR618574 W94078 BF515916 AI420148 BE220132 
    AW612946 AI633450 AW024968 AI702866 BC005212 BU623805 AW166319 BF513567 
    AI278772 AI805306 BG288573 CA393046 CD722774 BX113905 AI689789 AI373770 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for NSMCE4A (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c
    SP1:                    -     -     -     -     -           -                       -                 -     -                 -                                 
    SP2:                                                        -                       -                       -                 -                                 
    SP3:                    -     -     -     -     -           -                       -                 -     -                 -                                 
    SP4:                    -     -     -     -     -           -                       -                                                                           
    SP5:                                                        -                       -                 -     -                                                   


    ECgene alternative splicing isoforms for NSMCE4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    NSMCE4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGTCTTTG
    NSMCE4A Expression
    About this image

    NSMCE4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NSMCE4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.258798
        Custom PCR Arrays for NSMCE4A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for NSMCE4A
    OriGene qSTAR qPCR primer pairs in human, mouse for NSMCE4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NSMCE4A
    QuantiTect SYBR Green Assays in human, mouse, rat NSMCE4A
    QuantiFast Probe-based Assays in human, mouse, rat NSMCE4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSMCE4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for NSMCE4A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nsmce4a1 , 5 non-SMC element 4 homolog A (S. cerevisiae)1, 5 88.28(n)1
    87.93(a)1
      7 (73.19 cM)5
    678721  NM_001162855.11  NP_001156327.11 
     1305325235 
    chicken
    (Gallus gallus)
    Aves NSMCE4A1 non-SMC element 4 homolog A (S. cerevisiae) 65.25(n)
    58.5(a)
      423937  XM_004942332.1  XP_004942389.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    1 → many
    3(64366090-64378885)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.36412 Transcribed sequence with weak similarity to protein more 73.45(n)    AL851642.2 
    zebrafish
    (Danio rerio)
    Actinopterygii nsmce4a1 non-SMC element 4 homolog A (S. cerevisiae) 58.22(n)
    55.28(a)
      553544  NM_001020523.1  NP_001018359.1 


    ENSEMBL Gene Tree for NSMCE4A (if available)
    TreeFam Gene Tree for NSMCE4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for NSMCE4A gene
    EID32  
    1 SIMAP similar gene for NSMCE4A using alignment to 2 protein entries:     NSE4A_HUMAN (see all proteins):
    EID3

    NSMCE4A for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for NSMCE4A
    PGOHUM00000235006 PGOHUM00000245116


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for NSMCE4A (see all 475)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1461974761,2
    --123716104(+) AGAGCA/GGGCTC 2 -- int10--------
    rs1877456091,2
    --123716115(+) CCCTAA/GGAGGC 2 -- int10--------
    rs1926270211,2
    --123716124(+) GCAGGA/GAGCAC 2 -- int10--------
    rs1379397131,2
    --123716158(+) AAAGAC/TGCCTC 2 -- int10--------
    rs65857711,2
    C,F,H--123716216(+) GTGGGC/AACTGG 2 -- int115Minor allele frequency- A:0.02NA WA CSA EA 397
    rs1848328181,2
    --123716302(+) GGGCTC/GATGTT 2 -- int10--------
    rs1494550571,2
    --123716509(+) GGTCCA/GCAGGG 2 -- int10--------
    rs1405492481,2
    --123716619(+) ATGGC-/GGGGGG
            
    GGTGA
    2 -- cds10--------
    rs70998951,2
    C,F,H--123716730(+) TGTACA/GATACA 2 -- ut31 ese317Minor allele frequency- G:0.00NS EA NA WA CSA 1074
    rs122466931,2
    C,F,A,H--123716888(+) CCAGGT/GTAATC 2 -- int16Minor allele frequency- G:0.10NS EA NA 648

    HapMap Linkage Disequilibrium report for NSMCE4A (123716603 - 123734743 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for NSMCE4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv896051CNV Loss21882294
    nsv896053CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing NSMCE4A
    DNA2.0 Custom Variant and Variant Library Synthesis for NSMCE4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612987    OMIM disorders: --


    NSMCE4A for disorders           About GeneDecksing


    Export disorders for NSMCE4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for NSMCE4A gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with NSMCE4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PubMed id 18086888)1, 2 Taylor E.M.... Lehmann A.R. (Mol. Cell. Biol. 2008)
    2. Qri2/Nse4, a component of the essential Smc5/6 DNA repair complex. (PubMed id 15752197)1, 3 Hu B....Panaretou B. (Mol. Microbiol. 2005)
    3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. (PubMed id 21364888)1 Hudson J.J....Palecek J. (PLoS ONE 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 54780 HGNC: 25935 AceView: C10orf86 Ensembl:ENSG00000107672 euGenes: HUgn54780
    ECgene: NSMCE4A H-InvDB: NSMCE4A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for NSMCE4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for NSMCE4A gene:
    Search GeneIP for patents involving NSMCE4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for NSMCE4A  
     OriGene qPCR primer pairs and template standards for NSMCE4A   OriGene Protein Over-expression Lysate for NSMCE4A  
     OriGene MassSpec something-or-other for NSMCE4A   OriGene clones in human, mouse for NSMCE4A  
     OriGene qSTAR qPCR primer pairs in human, mouse for NSMCE4A   OriGene Purified Protein for NSMCE4A  
     OriGene ORF clones in mouse, rat for NSMCE4A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NSMCE4A   OriGene Custom Protein Services for NSMCE4A  

     
     
     Block miRNA regulation of human, mouse, rat NSMCE4A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing NSMCE4A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NSMCE4A Predesigned siRNA for gene silencing in human, mouse, rat NSMCE4A
     QuantiFast Probe-based Assays in human, mouse, rat NSMCE4A QuantiTect SYBR Green Assays in human, mouse, rat NSMCE4A
     Custom PCR Arrays for NSMCE4A Search Chromatin IP Primers for NSMCE4A
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NSMCE4A  Search GeneGlobe Interaction Network for NSMCE4A
     Regulatory tfbs in NSMCE4A promoter
     GenScript Custom Purified and Recombinant Proteins Services for NSMCE4A GenScript cDNA clones with any tag delivered in your preferred vector for NSMCE4A
     GenScript Custom Assay Services for NSMCE4A GenScript Custom overexpressing Cell Line Services for NSMCE4A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for NSMCE4A (NSE4A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     NSMCE4A antibodies
     NSMCE4A lysates
     Antibodies for NSMCE4A
     See all of Abcam's Antibodies, Kits and Proteins for NSMCE4A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for NSMCE4A
     Antibodies for NSMCE4A
     ELISAs for NSMCE4A
     CLIAs for NSMCE4A



     Browse ESI BIO Cell Lines and PureStem Progenitors for NSMCE4A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSMCE4A
     SwitchGear 3'UTR luciferase reporter plasmids for NSMCE4A
     SwitchGear Promoter luciferase reporter plasmids for NSMCE4A
     ThermoFisher Antibodies for NSMCE4A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSMCE4A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NSMCE4A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for NSMCE4A
     LSBio Antibodies in human, mouse, rat for NSMCE4A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NSMCE4A gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4