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NSMCE2 Gene

protein-coding   GIFtS: 50
GCID: GC08P126103

Non-SMC Element 2, MMS21 Homolog (S. Cerevisiae)

(Previous names: chromosome 8 open reading frame 36, non-SMC element 2 homolog...)
(Previous symbol: C8orf36)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Non-SMC Element 2, MMS21 Homolog (S. Cerevisiae)1 2     Non-SMC Element 2 Homolog (MMS21, S. Cerevisiae)1
C8orf361 2 3     Zinc Finger1
Non-SMC Element 2 Homolog2 3     NSE22
Non-Structural Maintenance Of Chromosomes Element 2 Homolog2 3     ZMIZ72
MMS212 3     E3 SUMO-Protein Ligase NSE22
hMMS212 3     Methyl Methanesulfonate Sensitivity Gene 212
MMS21 Homolog2 3     Zinc Finger, MIZ-Type Containing 72
Chromosome 8 Open Reading Frame 361     EC 6.3.2.-3
MIZ-Type Containing 71     EC 6.3.28

External Ids:    HGNC: 265131   Entrez Gene: 2860532   Ensembl: ENSG000001568317   UniProtKB: Q96MF73   

Export aliases for NSMCE2 gene to outside databases

Previous GC identifers: GC08P126175 GC08P121427


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for NSMCE2 Gene:
NSMCE2 (non-SMC element 2, MMS21 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with NSMCE2 include bipolar disorder, and breast and colorectal cancer. GO annotations related to this gene include SUMO ligase activity.

UniProtKB/Swiss-Prot: NSE2_HUMAN, Q96MF7
Function: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break
repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote
sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.
The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres)
cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to
shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment
to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and
maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO
protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA
repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase
and mitotic progression




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the NSMCE2 gene promoter:
         IRF-1   HNF-1A   MEF-2A   CBF-A   CBF-B   HNF-1   CP1A   aMEF-2   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNSMCE2 promoter sequence
   Search Chromatin IP Primers for NSMCE2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat NSMCE2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.13   Ensembl cytogenetic band:  8q24.13   HGNC cytogenetic band: 8q24.13

NSMCE2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NSMCE2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P126103:  view genomic region     (about GC identifiers)

Start:
126,103,921 bp from pter      End:
126,379,367 bp from pter
Size:
275,447 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NSE2_HUMAN, Q96MF7 (See protein sequence)
Recommended Name: E3 SUMO-protein ligase NSE2  
Size: 247 amino acids; 27932 Da
Subunit: Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3
and NDNL2
1 PDB 3D structure from and Proteopedia for NSMCE2:
2YU4 (3D)    
Secondary accessions: Q8N549

Explore the universe of human proteins at neXtProt for NSMCE2: NX_Q96MF7

Explore proteomics data for NSMCE2 at MOPED

Post-translational modifications: 

  • Sumoylated, possibly via autosumoylation1
  • Ubiquitination2 at Lys80, Lys114, Lys125, Lys130
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for NSMCE2 (Q96MF7)
     IVTQSQTNF  KAVQSTINHVKEER  QTEVSSEYSMDKAMVEFA 


    See NSMCE2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775956.1  
    ENSEMBL proteins: 
     ENSP00000429383   ENSP00000429612   ENSP00000287437   ENSP00000431002   ENSP00000430668  
     ENSP00000430313   ENSP00000429014   ENSP00000428846  

    NSMCE2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZMIZ: Zinc fingers, MIZ-type

    4 InterPro protein domains:
     IPR004181 Znf_MIZ
     IPR026846 Nse2(Mms21)
     IPR027370 Znf-RING_LisH
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q96MF7

    ProtoNet protein and cluster: Q96MF7

    UniProtKB/Swiss-Prot: NSE2_HUMAN, Q96MF7
    Similarity: Belongs to the NSE2 family
    Similarity: Contains 1 SP-RING-type zinc finger


    NSMCE2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NSE2_HUMAN, Q96MF7
    Function: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break
    repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote
    sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.
    The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres)
    cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to
    shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment
    to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and
    maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO
    protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA
    repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase
    and mitotic progression

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ----
    GO:0005515protein binding IPI18086888
    GO:0008270zinc ion binding IEA--
    GO:0019789SUMO ligase activity IDA17589526
         
    NSMCE2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Nsmce2 (no phenotypes)

    NSMCE2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for NSMCE2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NSMCE2
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NSMCE2

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    GenScript: all cDNA clones in your preferred vector: NSMCE2 (NM_173685)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSMCE2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    NSE2_HUMAN, Q96MF7: Nucleus. Chromosome, telomere. Note=Localizes to PML nuclear bodies in ALT cell lines
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion2
    cytosol1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex ----
    GO:0000781chromosome, telomeric region IDA17589526
    GO:0005634nucleus IDA--
    GO:0016605PML body IDA17589526
    GO:0030915Smc5-Smc6 complex IDA18086888

    NSMCE2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: NSE2_HUMAN, Q96MF7
    Pathway: Protein modification; protein sumoylation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for NSMCE2
    Interactions:

        Search GeneGlobe Interaction Network for NSMCE2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for NSMCE2 (Q96MF71 ENSP000002874374) via UniProtKB, MINT, STRING, and/or I2D (see all 62)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC6Q96SB81, ENSP000003234394EBI-2557388,EBI-605415 STRING: ENSP00000323439
    SMC5ENSP000003549574STRING: ENSP00000354957
    NDNL2ENSP000003306944STRING: ENSP00000330694
    NSMCE1ENSP000003550774STRING: ENSP00000355077
    ATRENSP000003437414STRING: ENSP00000343741
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000722telomere maintenance via recombination IMP17589526
    GO:0000724double-strand break repair via homologous recombination IMP16810316
    GO:0006303NOT double-strand break repair via nonhomologous end joining IMP16810316
    GO:0007067mitosis IEA--
    GO:0016567protein ubiquitination ----

    NSMCE2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for NSMCE2 (NSE2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for NSMCE2 gene: 
    NM_173685.2  

    Unigene Cluster for NSMCE2:

    Non-SMC element 2, MMS21 homolog (S. cerevisiae)
    Hs.388297  [show with all ESTs]
    Unigene Representative Sequence: BF966035
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523741 ENST00000520866 ENST00000519010 ENST00000517532 ENST00000287437(uc003yrw.2)
    ENST00000518013 ENST00000523824 ENST00000522563 ENST00000518146 ENST00000523549
    ENST00000519712 ENST00000517315 ENST00000521460
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidNSMCE2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat NSMCE2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat NSMCE2
      QuantiTect SYBR Green Assays in human, mouse, rat NSMCE2
      QuantiFast Probe-based Assays in human, mouse, rat NSMCE2

    Additional mRNA sequence: 

    AF147336.1 AK057002.1 BC032797.1 

    15 DOTS entries:

    DT.311499  DT.100815214  DT.95164454  DT.99941399  DT.100754810  DT.204918  DT.95164455  DT.100815211 
    DT.95164453  DT.100023269  DT.121467676  DT.91764688  DT.91764693  DT.100789091  DT.121467704 

    Selected AceView cDNA sequences (see all 120):

    AI638378 BM840663 BF512615 AI445325 H72555 CN479340 CR620646 CA446607 
    BE501754 AA580739 AF147336 AL527284 BM671181 BP872985 BM844770 BM993808 
    AA505468 AW438895 AA342118 CF127605 BU620878 BM761352 AI859890 BM452108 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    NSMCE2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGAGTCCA
    NSMCE2 Expression
    About this image


    NSMCE2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Limb (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    NSMCE2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    NSMCE2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.388297
        Custom PCR Arrays for NSMCE2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSMCE2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for NSMCE2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nsmce21 , 5 non-SMC element 2 homolog (MMS21, S. cerevisiae)1, 5 85.29(n)1
    84.21(a)1
      15 (25.19 cM)5
    685011  NM_026746.31  NP_081022.21 
     593741985 
    chicken
    (Gallus gallus)
    Aves NSMCE21 non-SMC element 2, MMS21 homolog (S. cerevisiae) 67.84(n)
    59.03(a)
      420333  NM_001277463.1  NP_001264392.1 
    lizard
    (Anolis carolinensis)
    Reptilia NSMCE26
    non-SMC element 2, MMS21 homolog (S. cerevisiae)
    48(a)
    1 ↔ 1
    4(5512082-5737760)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC530492 hypothetical protein MGC53049 72.45(n)    BC044994.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1945901 zgc:194590 51.79(n)
    38.39(a)
      564644  NM_001128718.1  NP_001122190.1 


    ENSEMBL Gene Tree for NSMCE2 (if available)
    TreeFam Gene Tree for NSMCE2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for NSMCE2 (see all 5407)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363274
    A breast cancer sample4--see VAR_0363272 L F mis40--------
    rs1149832331,2
    F--126106078(+) TTATCG/ATCCAG 1 -- int11Minor allele frequency- A:0.02WA 118
    rs1842079751,2
    --126106091(+) TAGAAC/TGCAGT 1 -- int10--------
    rs37635931,2
    C--126106163(-) CCCTCG/AGAAGG 1 -- int13Minor allele frequency- A:0.04NA EA 242
    rs1123083161,2
    C--126106171(+) GGGTCC/TAGGAC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1458622231,2
    --126106237(+) GTTGGG/TGTCTT 1 -- int10--------
    rs1883610051,2
    --126106281(+) CCTCAA/GGCAAT 1 -- int10--------
    rs1416772511,2
    C--126106288(+) CAATC-/TTC   
      CTGCCT
    TGCCC
    1 -- int10--------
    rs1163301251,2
    C,F--126106324(+) TATAGG/ACATGA 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1930173911,2
    --126106505(+) CAAGAC/TAGTCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for NSMCE2 (126103921 - 126353921 bp, first 250kb of NSMCE2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for NSMCE2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672529CNV Deletion23128226
    esv2737544CNV Deletion23290073
    esv2737543CNV Deletion23290073
    esv2617834CNV Deletion19546169
    esv1108735CNV Deletion17803354
    esv1989590CNV Deletion18987734
    esv2737541CNV Deletion23290073
    esv2656518CNV Deletion23128226
    esv2737542CNV Deletion23290073
    esv2676303CNV Deletion23128226

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    5 diseases for NSMCE2:    
    About MalaCards
    bipolar disorder    breast and colorectal cancer    prostate cancer    prostatitis
    colorectal cancer


    NSMCE2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): NSMCE2
    Human Genome Epidemiology (HuGE) Navigator: NSMCE2 (4 documents)

    Export disorders for NSMCE2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for NSMCE2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with NSMCE2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Susceptibility loci associated with prostate cancer progression and mortality. (PubMed id 20460480)1, 4 Gallagher D.J....Offit K. (Clin. Cancer Res. 2010)
    3. Prostate cancer risk associated loci in African Americans. (PubMed id 19549807)1, 4 Xu J....Isaacs W.B. (amp 2009)
    4. SMC5 and MMS21 are required for chromosome cohesion and mitotic progression. (PubMed id 19502785)1, 2 Behlke-Steinert S.... Margolis R.L. (Cell Cycle 2009)
    5. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PubMed id 18086888)1, 2 Taylor E.M.... Lehmann A.R. (Mol. Cell. Biol. 2008)
    6. The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins. (PubMed id 17589526)1, 2 Potts P.R. and Yu H. (Nat. Struct. Mol. Biol. 2007)
    7. Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double- strand breaks. (PubMed id 16810316)1, 2 Potts P.R.... Yu H. (EMBO J. 2006)
    8. Human MMS21/NSE2 is a SUMO ligase required for DNA repair. (PubMed id 16055714)1, 2 Potts P.R. and Yu H. (Mol. Cell. Biol. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 286053 HGNC: 26513 AceView: FLJ32440 Ensembl:ENSG00000156831 euGenes: HUgn286053
    ECgene: NSMCE2 H-InvDB: NSMCE2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for NSMCE2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for NSMCE2 gene:
    Search GeneIP for patents involving NSMCE2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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