Aliases for NSMCE1 Gene
External Ids for NSMCE1 Gene
Previous GeneCards Identifiers for NSMCE1 Gene
GeneCards Summary for NSMCE1 Gene
NSMCE1 (NSE1 Homolog, SMC5-SMC6 Complex Component) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and SUMOylation. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.
UniProtKB/Swiss-Prot for NSMCE1 Gene
Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NSMCE3. Is involved in positive regulation of response to DNA damage stimulus.