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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NSMCE1 Gene

protein-coding   GIFtS: 47
GCID: GC16M027236

Non-SMC Element 1 Homolog (S. Cerevisiae)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Non-SMC Element 1 Homolog (S. Cerevisiae)1 2
NSE12
Non-Structural Maintenance Of Chromosomes Element 1 Homolog2
EC 6.3.2.-3
Non-SMC Element 1 Homolog3

External Ids:    HGNC: 298971   Entrez Gene: 1973702   Ensembl: ENSG000001691897   UniProtKB: Q8WV223   

Export aliases for NSMCE1 gene to outside databases

Previous GC identifers: GC16M027144 GC16M025325


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for NSMCE1 Gene: 
NSMCE1 (non-SMC element 1 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with NSMCE1 include colon cancer. GO annotations related to this gene include ubiquitin-protein ligase activity and zinc ion binding.

UniProtKB/Swiss-Prot: NSE1_HUMAN, Q8WV22
Function: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous
recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3
cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in
ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome)
components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in
vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA
damage stimulus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NSMCE1 gene promoter:
         c-Fos   AP-1   AML1a   JunB   Fra-1   FosB   POU2F2C   HEN1   JunD   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNSMCE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NSMCE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NSMCE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.1   Ensembl cytogenetic band:  16p12.1   HGNC cytogenetic band: 16p12.1

NSMCE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NSMCE1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M027236:  view genomic region     (about GC identifiers)

Start:
27,236,312 bp from pter      End:
27,280,115 bp from pter
Size:
43,804 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NSE1_HUMAN, Q8WV22 (See protein sequence)
Recommended Name: Non-structural maintenance of chromosomes element 1 homolog  
Size: 266 amino acids; 30855 Da
Subunit: Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3
and NDNL2. NSMCE1, NSMCE4A or EID3 and NDNL2 probably form a subcomplex that bridges the head domains of the
SMC5:SMC6 heterodimer
Subcellular location: Nucleus. Chromosome, telomere (Probable)
Sequence caution: Sequence=AAF29011.1; Type=Frameshift; Positions=Several; Sequence=AAF29015.1; Type=Frameshift;
Positions=147;
2 PDB 3D structures from and Proteopedia for NSMCE1:
2CT0 (3D)        3NW0 (3D)    
Secondary accessions: D3DWF6 Q9P045 Q9P049

Explore the universe of human proteins at neXtProt for NSMCE1: NX_Q8WV22

Explore proteomics data for NSMCE1 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WV22

  • NSMCE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    NSMCE1 Protein Expression
    REFSEQ proteins: NP_659547.2  
    ENSEMBL proteins: 
     ENSP00000355077   ENSP00000456053   ENSP00000457893   ENSP00000455237   ENSP00000458859  
     ENSP00000456103   ENSP00000456754   ENSP00000454726  

    Human Recombinant Protein Products for NSMCE1: 
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    Novus Biologicals NSMCE1 Proteins
    Novus Biologicals NSMCE1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for NSMCE1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IEA--
    GO:0005634nucleus IEA--
    GO:0030915Smc5-Smc6 complex IDA18086888

    NSMCE1 for ontologies           About GeneDecksing



    NSMCE1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for NSMCE1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR011513 Nse1
     IPR001841 Znf_RING
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR014857 Znf_RING-like

    Graphical View of Domain Structure for InterPro Entry Q8WV22

    ProtoNet protein and cluster: Q8WV22

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: NSE1_HUMAN, Q8WV22
    Similarity: Belongs to the NSE1 family
    Similarity: Contains 1 NSE1-type zinc finger


    NSMCE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NSE1_HUMAN, Q8WV22
    Function: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous
    recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3
    cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in
    ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome)
    components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in
    vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA
    damage stimulus

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI14701739
    GO:0008270zinc ion binding IEA--
         
    NSMCE1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for NSMCE1:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for NSMCE1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for NSMCE1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for NSMCE1 
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    miRNA
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    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSMCE1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NSMCE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/13 Interacting proteins for NSMCE1 (Q8WV221 ENSP000003550774) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC6Q96SB81, ENSP000003234394EBI-2557372,EBI-605415 STRING: ENSP00000323439
    NDNL2Q96MG71, ENSP000003306944EBI-2557372,EBI-2557356 STRING: ENSP00000330694
    SMC5ENSP000003549574STRING: ENSP00000354957
    NSMCE4AENSP000003580194STRING: ENSP00000358019
    NSMCE2ENSP000002874374STRING: ENSP00000287437
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006310DNA recombination IEA--
    GO:0016567protein ubiquitination IDA--
    GO:0035556intracellular signal transduction IEA--
    GO:2001022positive regulation of response to DNA damage stimulus IMP18086888

    NSMCE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NSMCE1 (NSE1)

    Search CenterWatch for drugs/clinical trials and news about NSMCE1 / NSE1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NSMCE1 gene: 
    NM_145080.3  

    Unigene Cluster for NSMCE1:

    Non-SMC element 1 homolog (S. cerevisiae)
    Hs.284295  [show with all ESTs]
    Unigene Representative Sequence: AK056795
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361439(uc002doi.1) ENST00000569236(uc002doj.1) ENST00000565070
    ENST00000565384 ENST00000562039 ENST00000566087 ENST00000563273 ENST00000564342
    ENST00000563900 ENST00000561960 ENST00000567710 ENST00000563512 ENST00000565626
    ENST00000567375
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NSMCE1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate NSMCE1
    SwitchGear 3'UTR luciferase reporter plasmidNSMCE1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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                         Customized lentivirus expression plasmids for stable overexpression of NSMCE1 
    Primer
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    OriGene qPCR primer pairs and template standards for NSMCE1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NSMCE1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NSMCE1

    Additional mRNA sequence: 

    AF161451.1 AF161455.1 AK056795.1 AK315674.1 BC018938.2 

    13 DOTS entries:

    DT.100798927  DT.95301604  DT.92439712  DT.95301590  DT.95323211  DT.435610  DT.91948312  DT.95301592 
    DT.120660993  DT.75146784  DT.95301584  DT.95301594  DT.97779468 

    24/274 AceView cDNA sequences (see all 274):

    BQ017865 AA364561 CR593451 BM995939 CA431456 BM717601 CA426854 AW273648 
    AW662529 BM918538 BU618164 AA659320 BU191768 BP351895 CB117974 BU685363 
    BM807368 BM194137 CR598954 BG319475 CR625772 CA449214 BQ422148 BU679528 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NSMCE1 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d
    SP1:              -           -                                         -                       -     -                                             
    SP2:              -     -     -           -     -                       -                       -     -                                             
    SP3:              -     -     -           -     -                       -                       -     -                                             
    SP4:                                      -     -                       -                                                                           
    SP5:                                            -                       -                       -     -                                             


    ECgene alternative splicing isoforms for NSMCE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NSMCE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCGCAATGC
    NSMCE1 Expression
    About this image


    See NSMCE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NSMCE1

    SOURCE GeneReport for Unigene cluster: Hs.284295
        SABiosciences Custom PCR Arrays for NSMCE1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSMCE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for NSMCE1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nsmce11 , 5 non-SMC element 1 homolog (S. cerevisiae)1, 5 86.09(n)1
    89.47(a)1
      7 (68.87 cM)5
    677111  NM_026330.31  NP_080606.21 
     1254676405 
    chicken
    (Gallus gallus)
    Aves NSMCE11 non-SMC element 1 homolog (S. cerevisiae) 66.09(n)
    60.87(a)
      416584  XM_414884.3  XP_414884.1 
    lizard
    (Anolis carolinensis)
    Reptilia NSMCE16
    non-SMC element 1 homolog (S. cerevisiae)
    53(a)
    1 ↔ 1
    GL343612.1(167153-175342)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687392 hypothetical protein MGC68739 70.86(n)    BC060339.1 
    zebrafish
    (Danio rerio)
    Actinopterygii nsmce11 non-SMC element 1 homolog (S. cerevisiae) 56.77(n)
    45.85(a)
      436824  NM_001002551.1  NP_001002551.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG113296
    --
    23(a)
    1 ↔ 1
    2L(6676649-6677625)


    ENSEMBL Gene Tree for NSMCE1 (if available)
    TreeFam Gene Tree for NSMCE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/877 SNPs in NSMCE1 are shown (see all 877)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs586913601,2
    C--25351179(+) ATATA-/AA/T  
            
    AAACT
    1 -- int10--------
    rs1891951341,2
    --27235883(+) GTCAGA/GGAGAG 1 -- int10--------
    rs1815217731,2
    --27235986(+) AGCACA/GCATCC 1 -- int10--------
    rs1843343681,2
    --27236002(+) AAACGC/TCCAGC 1 -- int10--------
    rs1895318291,2
    --27236030(+) AGTGGC/GACCTT 1 -- int10--------
    rs71926331,2
    C,F,A,H--27236095(+) AGGTTC/TGGGCC 1 -- int121Minor allele frequency- T:0.40NS EA NA WA 2344
    rs798796581,2
    C,F--27236163(+) GGCAAG/CGACAG 1 -- int11Minor allele frequency- C:0.02EA 120
    rs1174911311,2
    C,F--27236218(+) TGCTGG/AAGCCC 1 -- int11Minor allele frequency- A:0.03EA 120
    rs664657071,2
    C--27236311(+) AGACG-/AGGGCTG 1 -- int10--------
    rs29581,2
    C,F,A,H--27236403(+) AACACG/AGACGC 1 -- ut31 ese326Minor allele frequency- A:0.34MN NA NS EA WA CSA 2864

    HapMap Linkage Disequilibrium report for NSMCE1 (27236312 - 27280115 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for NSMCE1: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for NSMCE1:    About MalaCards
    colon cancer    


    NSMCE1 for disorders           About GeneDecksing


    Export disorders for NSMCE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NSMCE1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with NSMCE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. (PubMed id 21364888)1, 2 Hudson J.J....Palecek J. (2011)
    2. MAGE-RING protein complexes comprise a family of E3 u biquitin ligases. (PubMed id 20864041)1, 2 Doyle J.M....Potts P.R. (2010)
    3. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PubMed id 18086888)1, 2 Taylor E.M....Lehmann A.R. (2008)
    4. Coordination of DNA damage responses via the Smc5/Smc6 complex. (PubMed id 14701739)1, 2 Harvey S.H.... O'Connell M.J. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. (PubMed id 11927594)1, 3 Fujioka Y....Kohno K. (2002)
    7. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    8. Mining and characterization of ubiquitin E3 ligases ex pressed in the mouse testis. (PubMed id 22992278)1 Hou X....Han C. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 197370 HGNC: 29897 AceView: NSE1 Ensembl:ENSG00000169189 euGenes: HUgn197370
    ECgene: NSMCE1 H-InvDB: NSMCE1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NSMCE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NSMCE1 gene:
    Search GeneIP for patents involving NSMCE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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