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Aliases for NSMCE1 Gene

Aliases for NSMCE1 Gene

  • Non-SMC Element 1 Homolog (S. Cerevisiae) 2 3
  • Non-Structural Maintenance Of Chromosomes Element 1 Homolog 3
  • Non-SMC Element 1 Homolog 4
  • EC 6.3.2.- 4
  • NSE1 3

External Ids for NSMCE1 Gene

Summaries for NSMCE1 Gene

GeneCards Summary for NSMCE1 Gene

NSMCE1 (Non-SMC Element 1 Homolog (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for NSMCE1 Gene

  • Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSMCE1 Gene

Genomics for NSMCE1 Gene

Genomic Location for NSMCE1 Gene

Start:
27,224,991 bp from pter
End:
27,268,794 bp from pter
Size:
43,804 bases
Orientation:
Minus strand

Genomic View for NSMCE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NSMCE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSMCE1 Gene

Regulatory Elements for NSMCE1 Gene

Proteins for NSMCE1 Gene

  • Protein details for NSMCE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV22-NSE1_HUMAN
    Recommended name:
    Non-structural maintenance of chromosomes element 1 homolog
    Protein Accession:
    Q8WV22
    Secondary Accessions:
    • D3DWF6
    • Q9P045
    • Q9P049

    Protein attributes for NSMCE1 Gene

    Size:
    266 amino acids
    Molecular mass:
    30855 Da
    Quaternary structure:
    • Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2. NSMCE1, NSMCE4A or EID3 and NDNL2 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer.
    SequenceCaution:
    • Sequence=AAF29011.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF29015.1; Type=Frameshift; Positions=147; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NSMCE1 Gene

neXtProt entry for NSMCE1 Gene

Proteomics data for NSMCE1 Gene at MOPED

Post-translational modifications for NSMCE1 Gene

No data available for DME Specific Peptides for NSMCE1 Gene

Domains for NSMCE1 Gene

Protein Domains for NSMCE1 Gene

UniProtKB/Swiss-Prot:

NSE1_HUMAN
Family:
  • Belongs to the NSE1 family.:
    • Q8WV22
Similarity:
  • Contains 1 NSE1-type zinc finger.:
    • Q8WV22
genes like me logo Genes that share domains with NSMCE1: view

No data available for Gene Families for NSMCE1 Gene

Function for NSMCE1 Gene

Molecular function for NSMCE1 Gene

UniProtKB/Swiss-Prot Function: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Has in vitro ubiquitin ligase activity in presence of NDNL2. Is involved in positive regulation of response to DNA damage stimulus.

Enzyme Numbers (IUBMB) for NSMCE1 Gene

Gene Ontology (GO) - Molecular Function for NSMCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20864041
GO:0005515 protein binding IPI 14701739
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with NSMCE1: view

Phenotypes for NSMCE1 Gene

GenomeRNAi human phenotypes for NSMCE1:
genes like me logo Genes that share phenotypes with NSMCE1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for NSMCE1 Gene

Localization for NSMCE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSMCE1 Gene

Nucleus. Chromosome, telomere.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NSMCE1 Gene COMPARTMENTS Subcellular localization image for NSMCE1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NSMCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0030915 Smc5-Smc6 complex IDA 18086888
genes like me logo Genes that share ontologies with NSMCE1: view

Pathways for NSMCE1 Gene

SuperPathways for NSMCE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NSMCE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006310 DNA recombination IEA --
GO:0016567 protein ubiquitination IDA 20864041
GO:0016925 protein sumoylation TAS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with NSMCE1: view

No data available for Pathways by source for NSMCE1 Gene

Transcripts for NSMCE1 Gene

Unigene Clusters for NSMCE1 Gene

Non-SMC element 1 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NSMCE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c · 14d
SP1: - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - -
SP5: - - - -
SP6: - - - - -
SP7: - -
SP8: -
SP9:
SP10: - - - - -

Relevant External Links for NSMCE1 Gene

GeneLoc Exon Structure for
NSMCE1
ECgene alternative splicing isoforms for
NSMCE1

Expression for NSMCE1 Gene

mRNA expression in normal human tissues for NSMCE1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NSMCE1 Gene

SOURCE GeneReport for Unigene cluster for NSMCE1 Gene Hs.284295

genes like me logo Genes that share expressions with NSMCE1: view

Orthologs for NSMCE1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NSMCE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NSMCE1 36
  • 99 (n)
  • 99.25 (a)
NSMCE1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NSMCE1 36
  • 87.89 (n)
  • 90.23 (a)
NSMCE1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NSMCE1 36
  • 87.72 (n)
  • 91.35 (a)
NSMCE1 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nsmce1 36
  • 86.09 (n)
  • 89.47 (a)
Nsmce1 16
Nsmce1 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NSMCE1 37
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NSMCE1 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nsmce1 36
  • 86.34 (n)
  • 91.73 (a)
chicken
(Gallus gallus)
Aves NSMCE1 36
  • 66.09 (n)
  • 60.87 (a)
NSMCE1 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NSMCE1 37
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68739 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nsmce1 36
  • 60.82 (n)
  • 51.79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10623 36
zebrafish
(Danio rerio)
Actinopterygii nsmce1 36
  • 56.62 (n)
  • 45.85 (a)
nsmce1 37
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11329 37
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NSE1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
OneToOne
Species with no ortholog for NSMCE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSMCE1 Gene

ENSEMBL:
Gene Tree for NSMCE1 (if available)
TreeFam:
Gene Tree for NSMCE1 (if available)

Paralogs for NSMCE1 Gene

No data available for Paralogs for NSMCE1 Gene

Variants for NSMCE1 Gene

Sequence variations from dbSNP and Humsavar for NSMCE1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs2958 -- 27,225,082(+) AACAC(A/G)GACGC utr-variant-3-prime
rs1127228 -- 27,226,789(-) ATGGA(A/G)CAATA synonymous-codon, reference
rs3211442 -- 27,233,042(-) CGGAG(C/G)AGGTG reference, missense
rs4238951 -- 27,251,205(+) ATATA(A/T)ATAAA intron-variant
rs4238952 -- 27,254,149(+) AATAA(C/T)ATTGG intron-variant

Relevant External Links for NSMCE1 Gene

HapMap Linkage Disequilibrium report
NSMCE1

No data available for Structural Variations from Database of Genomic Variants (DGV) for NSMCE1 Gene

Disorders for NSMCE1 Gene

No disorders were found for NSMCE1 Gene.

No data available for UniProtKB/Swiss-Prot for NSMCE1 Gene

Publications for NSMCE1 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  2. Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair. (PMID: 11927594) Fujioka Y. … Kohno K. (J. Biol. Chem. 2002) 2 3
  3. Coordination of DNA damage responses via the Smc5/Smc6 complex. (PMID: 14701739) Harvey S.H. … O'Connell M.J. (Mol. Cell. Biol. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. (PMID: 18086888) Taylor E.M. … Lehmann A.R. (Mol. Cell. Biol. 2008) 3 4

Products for NSMCE1 Gene

Sources for NSMCE1 Gene

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