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Aliases for NSMAF Gene

Aliases for NSMAF Gene

  • Neutral Sphingomyelinase (N-SMase) Activation Associated Factor 2 3
  • FAN 3 4 6
  • Factor Associated With Neutral Sphingomyelinase Activation 3 4
  • Factor Associated With N-SMase Activation 3 4
  • Protein FAN 3

External Ids for NSMAF Gene

Previous GeneCards Identifiers for NSMAF Gene

  • GC08M059435
  • GC08M059219
  • GC08M059546
  • GC08M059658
  • GC08M054983
  • GC08M059496

Summaries for NSMAF Gene

Entrez Gene Summary for NSMAF Gene

  • This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

GeneCards Summary for NSMAF Gene

NSMAF (Neutral Sphingomyelinase (N-SMase) Activation Associated Factor) is a Protein Coding gene. Diseases associated with NSMAF include 8p11 myeloproliferative syndrome. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway and TNF receptor signaling pathway. GO annotations related to this gene include receptor signaling protein activity. An important paralog of this gene is WDFY3.

UniProtKB/Swiss-Prot for NSMAF Gene

  • Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSMAF Gene

Genomics for NSMAF Gene

Regulatory Elements for NSMAF Gene

Genomic Location for NSMAF Gene

58,583,504 bp from pter
58,659,845 bp from pter
76,342 bases
Minus strand

Genomic View for NSMAF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NSMAF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSMAF Gene

Proteins for NSMAF Gene

  • Protein details for NSMAF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein FAN
    Protein Accession:
    Secondary Accessions:
    • B4DFB0
    • E9PCH0
    • Q8IW26

    Protein attributes for NSMAF Gene

    917 amino acids
    Molecular mass:
    104372 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NSMAF Gene


neXtProt entry for NSMAF Gene

Proteomics data for NSMAF Gene at MOPED

Post-translational modifications for NSMAF Gene

  • Ubiquitination at Lys467
  • Modification sites at PhosphoSitePlus

Other Protein References for NSMAF Gene

Antibody Products

No data available for DME Specific Peptides for NSMAF Gene

Domains for NSMAF Gene

Gene Families for NSMAF Gene

Suggested Antigen Peptide Sequences for NSMAF Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 BEACH domain.
  • Contains 6 WD repeats.
  • Contains 1 BEACH domain.
  • Contains 1 GRAM domain.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with NSMAF: view

Function for NSMAF Gene

Molecular function for NSMAF Gene

GENATLAS Biochemistry:
neutral sphingomyelinase (N-Smase) activation factor,activated by TNFRSF1A,interacting signal transduction events that induce inflammatory and proliferative responses to TNF stimulation,LYST and mouse beige homolog
UniProtKB/Swiss-Prot Function:
Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE

Gene Ontology (GO) - Molecular Function for NSMAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity TAS 8808629
GO:0005515 protein binding IPI 17599063
GO:0005543 phospholipid binding IBA --
GO:0016230 sphingomyelin phosphodiesterase activator activity IEA --
genes like me logo Genes that share ontologies with NSMAF: view
genes like me logo Genes that share phenotypes with NSMAF: view

Animal Models for NSMAF Gene

MGI Knock Outs for NSMAF:

Animal Model Products

CRISPR Products

miRNA for NSMAF Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for NSMAF Gene

Localization for NSMAF Gene

Subcellular locations from

Jensen Localization Image for NSMAF Gene COMPARTMENTS Subcellular localization image for NSMAF gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NSMAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 8808629
GO:0012505 endomembrane system IBA --
GO:0019898 extrinsic component of membrane IBA --
genes like me logo Genes that share ontologies with NSMAF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NSMAF Gene

Pathways for NSMAF Gene

genes like me logo Genes that share pathways with NSMAF: view

Pathways by source for NSMAF Gene

Gene Ontology (GO) - Biological Process for NSMAF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006672 ceramide metabolic process TAS 8808629
GO:0007165 signal transduction TAS 8808629
GO:0016197 endosomal transport IBA --
GO:0035556 intracellular signal transduction TAS 8808629
GO:0043065 positive regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with NSMAF: view

Compounds for NSMAF Gene

(35) HMDB Compounds for NSMAF Gene

Compound Synonyms Cas Number PubMed IDs
Not Available
Not Available
Not Available
Not Available
Not Available

(1) Novoseek inferred chemical compound relationships for NSMAF Gene

Compound -log(P) Hits PubMed IDs
ceramide 65.7 2
genes like me logo Genes that share compounds with NSMAF: view

Transcripts for NSMAF Gene

Unigene Clusters for NSMAF Gene

Neutral sphingomyelinase (N-SMase) activation associated factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NSMAF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a ·
SP1: - - -
SP3: -

ExUns: 24b ^ 25 ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b
SP1: - -
SP3: -

Relevant External Links for NSMAF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NSMAF Gene

mRNA expression in normal human tissues for NSMAF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for NSMAF Gene

This gene is overexpressed in Lymph node (26.2), Spleen (7.3), and Blymphocyte (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NSMAF Gene

SOURCE GeneReport for Unigene cluster for NSMAF Gene Hs.372000

mRNA Expression by UniProt/SwissProt for NSMAF Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with NSMAF: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for NSMAF Gene

Orthologs for NSMAF Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NSMAF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia NSMAF 35
  • 85.1 (n)
  • 89.53 (a)
  • 88 (a)
(Canis familiaris)
Mammalia NSMAF 35
  • 88.86 (n)
  • 92.77 (a)
  • 92 (a)
(Mus musculus)
Mammalia Nsmaf 35
  • 87.71 (n)
  • 92.04 (a)
Nsmaf 16
Nsmaf 36
  • 90 (a)
(Pan troglodytes)
Mammalia NSMAF 35
  • 99.75 (n)
  • 99.89 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Nsmaf 35
  • 87.28 (n)
  • 91.49 (a)
(Monodelphis domestica)
Mammalia NSMAF 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia NSMAF 36
  • 84 (a)
(Gallus gallus)
Aves NSMAF 35
  • 75.9 (n)
  • 79.52 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia NSMAF 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nsmaf 35
  • 70.56 (n)
  • 73.56 (a)
(Danio rerio)
Actinopterygii nsmaf 35
  • 67.78 (n)
  • 71.41 (a)
nsmaf 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000429 35
  • 47.6 (n)
  • 41.5 (a)
(Caenorhabditis elegans)
Secernentea T01H10.8 36
  • 6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BPH1 36
  • 11 (a)
Species with no ortholog for NSMAF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NSMAF Gene

Gene Tree for NSMAF (if available)
Gene Tree for NSMAF (if available)

Paralogs for NSMAF Gene

Paralogs for NSMAF Gene

(1) SIMAP similar genes for NSMAF Gene using alignment to 3 proteins: Pseudogenes for NSMAF Gene

genes like me logo Genes that share paralogs with NSMAF: view

Variants for NSMAF Gene

Sequence variations from dbSNP and Humsavar for NSMAF Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs901954 -- 58,613,180(-) taaaa(A/T)atatt intron-variant
rs931396 -- 58,587,448(-) AAGTC(A/T)ACTTT intron-variant
rs973807 -- 58,658,728(+) AATGC(C/T)CTGGG intron-variant
rs1050488 -- 58,583,931(-) GTTGC(C/T)ATTCT utr-variant-3-prime
rs1050504 -- 58,583,857(-) TCCCC(A/G)TATGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for NSMAF Gene

Variant ID Type Subtype PubMed ID
nsv890938 CNV Gain 21882294
nsv890939 CNV Gain 21882294
nsv397168 CNV Loss 16902084
nsv831325 CNV Gain 17160897
esv271778 CNV Insertion 20981092

Relevant External Links for NSMAF Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSMAF Gene

Disorders for NSMAF Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for NSMAF Gene in MalaCards »

(1) Disease for NSMAF Gene

(2) Novoseek inferred disease relationships for NSMAF Gene

Disease -log(P) Hits PubMed IDs
necrosis 33 2
tumors 11 2

Relevant External Links for NSMAF

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with NSMAF: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for NSMAF Gene

Publications for NSMAF Gene

  1. FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase. (PMID: 8808629) Adam-Klages S. … Kroenke M. (Cell 1996) 2 3 4
  2. Assignment of the human FAN protein gene (NSMAF) to human chromosome region 8q12-->q13 by in situ hybridization. (PMID: 10640829) Zhang Y. … Schlegelberger B. (Cytogenet. Cell Genet. 1999) 2 3
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. Distinct adapter proteins mediate acid versus neutral sphingomyelinase activation through the p55 receptor for tumor necrosis factor. (PMID: 9620659) Adam-Klages S. … KrAPnke M. (J. Leukoc. Biol. 1998) 3 23
  5. CD40 signals apoptosis through FAN-regulated activation of the sphingomyelin-ceramide pathway. (PMID: 10601289) SAcgui B. … Levade T. (J. Biol. Chem. 1999) 3 23

Products for NSMAF Gene

Sources for NSMAF Gene

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