Aliases for NSMAF Gene
External Ids for NSMAF Gene
Previous GeneCards Identifiers for NSMAF Gene
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
GeneCards Summary for NSMAF Gene
NSMAF (Neutral Sphingomyelinase (N-SMase) Activation Associated Factor) is a Protein Coding gene. Diseases associated with NSMAF include 8p11 myeloproliferative syndrome. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway and TNF receptor signaling pathway. GO annotations related to this gene include receptor signaling protein activity. An important paralog of this gene is WDFY3.
UniProtKB/Swiss-Prot for NSMAF Gene
Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE