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Aliases for NSL1 Gene

Aliases for NSL1 Gene

  • NSL1, MIS12 Kinetochore Complex Component 2 3
  • C1orf48 3 4
  • NSL1, MIND Kinetochore Complex Component, Homolog (S. Cerevisiae) 2
  • NSL1, MIND Kinetochore Complex Component, Homolog 3
  • Kinetochore-Associated Protein NSL1 Homolog 3
  • Chromosome 1 Open Reading Frame 48 2
  • MIS14 3
  • DC8 3

External Ids for NSL1 Gene

Previous Symbols for NSL1 Gene

  • C1orf48

Summaries for NSL1 Gene

Entrez Gene Summary for NSL1 Gene

  • This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]

GeneCards Summary for NSL1 Gene

NSL1 (NSL1, MIS12 Kinetochore Complex Component) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NSL1 Gene

  • Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.

Gene Wiki entry for NSL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSL1 Gene

Genomics for NSL1 Gene

Genomic Location for NSL1 Gene

Start:
212,726,153 bp from pter
End:
212,791,797 bp from pter
Size:
65,645 bases
Orientation:
Minus strand

Genomic View for NSL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSL1 Gene

Regulatory Elements for NSL1 Gene

Proteins for NSL1 Gene

  • Protein details for NSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IY1-NSL1_HUMAN
    Recommended name:
    Kinetochore-associated protein NSL1 homolog
    Protein Accession:
    Q96IY1
    Secondary Accessions:
    • E7ETD5
    • Q5SY75
    • Q9H2M5
    • Q9NRN8
    • Q9Y415

    Protein attributes for NSL1 Gene

    Size:
    281 amino acids
    Molecular mass:
    32162 Da
    Quaternary structure:
    • Component of the MIS12 complex composed of MIS12, DSN1, NSL1/DC8 and PMF1. Interacts with CASC5.
    SequenceCaution:
    • Sequence=AAF86877.1; Type=Frameshift; Positions=41; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NSL1 Gene

    Alternative splice isoforms for NSL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NSL1 Gene

Proteomics data for NSL1 Gene at MOPED

Post-translational modifications for NSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NSL1 Gene

No data available for DME Specific Peptides for NSL1 Gene

Domains for NSL1 Gene

Protein Domains for NSL1 Gene

genes like me logo Genes that share domains with NSL1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for NSL1 Gene

Function for NSL1 Gene

Molecular function for NSL1 Gene

UniProtKB/Swiss-Prot Function: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.

Gene Ontology (GO) - Molecular Function for NSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15502821
genes like me logo Genes that share ontologies with NSL1: view

miRNA for NSL1 Gene

miRTarBase miRNAs that target NSL1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for NSL1 Gene

Localization for NSL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSL1 Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NSL1 Gene COMPARTMENTS Subcellular localization image for NSL1 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 4
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for NSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000444 MIS12/MIND type complex IDA 16585270
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NSL1: view

Pathways for NSL1 Gene

genes like me logo Genes that share pathways with NSL1: view

Pathways by source for NSL1 Gene

Gene Ontology (GO) - Biological Process for NSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007059 chromosome segregation IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NSL1: view

Transcripts for NSL1 Gene

Unigene Clusters for NSL1 Gene

NSL1, MIND kinetochore complex component, homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NSL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - -
SP8:

Relevant External Links for NSL1 Gene

GeneLoc Exon Structure for
NSL1
ECgene alternative splicing isoforms for
NSL1

Expression for NSL1 Gene

mRNA expression in normal human tissues for NSL1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NSL1 Gene

SOURCE GeneReport for Unigene cluster for NSL1 Gene Hs.497692

genes like me logo Genes that share expressions with NSL1: view

Orthologs for NSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NSL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NSL1 36
  • 99.41 (n)
  • 98.58 (a)
NSL1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NSL1 36
  • 87.35 (n)
  • 81.75 (a)
NSL1 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NSL1 36
  • 87.5 (n)
  • 79.64 (a)
NSL1 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nsl1 36
  • 75.36 (n)
  • 67.5 (a)
Nsl1 16
Nsl1 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NSL1 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NSL1 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nsl1 36
  • 76.19 (n)
  • 68.93 (a)
chicken
(Gallus gallus)
Aves NSL1 36
  • 60.44 (n)
  • 47.47 (a)
NSL1/DC31 37
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NSL1 37
  • 36 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nsl1 36
  • 54.15 (n)
  • 44.08 (a)
zebrafish
(Danio rerio)
Actinopterygii nsl1 36
  • 48.58 (n)
  • 35.64 (a)
nsl1 37
  • 30 (a)
OneToOne
Species with no ortholog for NSL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSL1 Gene

ENSEMBL:
Gene Tree for NSL1 (if available)
TreeFam:
Gene Tree for NSL1 (if available)

Paralogs for NSL1 Gene

Selected SIMAP similar genes for NSL1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NSL1: view

No data available for Paralogs for NSL1 Gene

Variants for NSL1 Gene

Sequence variations from dbSNP and Humsavar for NSL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15702 - 212,738,494(-) CTGAC(A/G)TGGTA utr-variant-3-prime, reference, missense, intron-variant
rs1007036 -- 212,778,022(+) CAATA(A/G)CAAAA intron-variant
rs1021994 -- 212,749,408(-) GTGAT(C/T)ACATC intron-variant
rs1032964 -- 212,754,829(-) AGCTT(C/T)GCTTC intron-variant
rs1032965 -- 212,754,815(-) GCAGC(A/G)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NSL1 Gene

Variant ID Type Subtype PubMed ID
dgv179e1 CNV Complex 17122850
nsv159271 CNV Loss 16902084

Relevant External Links for NSL1 Gene

HapMap Linkage Disequilibrium report
NSL1

Disorders for NSL1 Gene

Relevant External Links for NSL1

Genetic Association Database (GAD)
NSL1
Human Genome Epidemiology (HuGE) Navigator
NSL1
genes like me logo Genes that share disorders with NSL1: view

No data available for UniProtKB/Swiss-Prot for NSL1 Gene

Publications for NSL1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. (PMID: 15502821) Obuse C. … Yanagida M. (Nat. Cell Biol. 2004) 3 4
  3. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. (PMID: 16585270) Kline S.L. … Desai A. (J. Cell Biol. 2006) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. (PMID: 17981135) Kiyomitsu T. … Yanagida M. (Dev. Cell 2007) 3 4

Products for NSL1 Gene

Sources for NSL1 Gene

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