Aliases for NSL1 Gene
External Ids for NSL1 Gene
Previous HGNC Symbols for NSL1 Gene
Previous GeneCards Identifiers for NSL1 Gene
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014]
GeneCards Summary for NSL1 Gene
UniProtKB/Swiss-Prot for NSL1 Gene
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.