Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

NSL1 Gene

protein-coding   GIFtS: 51
GCID: GC01M212899

NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)

(Previous name: chromosome 1 open reading frame 48 )
(Previous symbol: C1orf48)
  Search for NSL1
in our new
 Human Malady Compendium 
Biological research products
for NSL1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
NSL1, MIND Kinetochore Complex Component, Homolog (S. Cerevisiae)1 2     DKFZP566O16461
C1orf481 2 3     Chromosome 1 Open Reading Frame 481
MIS141 2     Kinetochore-Associated Protein NSL1 Homolog2
DC81     

External Ids:    HGNC: 245481   Entrez Gene: 259362   Ensembl: ENSG000001176977   OMIM: 6091745   UniProtKB: Q96IY13   

Export aliases for NSL1 gene to outside databases

Previous GC identifers: GC01M210967 GC01M183576


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NSL1:
This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are
chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division.
The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a
component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric
heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: NSL1_HUMAN, Q96IY1
Function: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore
formation during mitosis

Gene Wiki entry for NSL1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NSL1 gene promoter:
         Nkx3-1 v4   Sox5   AML1a   XBP-1   POU2F1   POU2F1a   FOXO4   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidNSL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for NSL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NSL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q41

NSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NSL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M212899:  view genomic region     (about GC identifiers)

Start:
212,899,495 bp from pter      End:
212,965,139 bp from pter
Size:
65,645 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NSL1_HUMAN, Q96IY1 (See protein sequence)
Recommended Name: Kinetochore-associated protein NSL1 homolog  
Size: 281 amino acids; 32162 Da
Subunit: Component of the MIS12 complex composed of MIS12, DSN1, NSL1/DC8 and PMF1. Interacts with CASC5
Subcellular location: Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore
Sequence caution: Sequence=AAF86877.1; Type=Frameshift; Positions=41;
Secondary accessions: E7ETD5 Q5SY75 Q9H2M5 Q9NRN8 Q9Y415
Alternative splicing: 2 isoforms:  Q96IY1-1   Q96IY1-2   

Explore the universe of human proteins at neXtProt for NSL1: NX_Q96IY1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96IY1

  • NSL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001036014.1  NP_056286.3  

    ENSEMBL proteins: 
     ENSP00000355945   ENSP00000355944   ENSP00000355943   ENSP00000355942   ENSP00000388406  
    Reactome Protein details: Q96IY1
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate (see all 3): NSL1
    OriGene Custom Protein Services for NSL1 
    GenScript Custom Purified and Recombinant Proteins Services for NSL1
    Novus Biologicals NSL1 Proteins
    Novus Biologicals NSL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for NSL1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000444MIS12/MIND type complex IDA16585270
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--


    NSL1 for ontologies           About GeneDecksing



    NSL1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: NSL1
    OriGene Custom Antibody Services for NSL1 
    GenScript Custom Superior Antibodies Services for NSL1
    Novus Biologicals NSL1 Antibodies
    Search for Antibodies for NSL1 at Abcam  
    Uscn Antibodies for NSL1
    ThermoFisher Antibodies for NSL1

    Assay Products for NSL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NSL1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NSL1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NSL1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR013950 Kinetochore_Mis14

    Graphical View of Domain Structure for InterPro Entry Q96IY1

    ProtoNet protein and cluster: Q96IY1

    1 Blocks protein family: IPB002052 N-6 Adenine-specific DNA methylase


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: NSL1_HUMAN, Q96IY1
    Function: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore
    formation during mitosis

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NSL1
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate NSL1 (see all 47):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-607 hsa-miR-642a hsa-miR-578 hsa-miR-550a* hsa-miR-3667-5p hsa-miR-3161
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NSL1 (see all 7)
    OriGene shRNA RFP: NSL1
    OriGene siRNA: NSL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NSL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for NSL1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NSL1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NSL1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NSL1 (NM_015471)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NSL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSL1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for NSL1
    Search LifeMap BioReagents cell lines for NSL1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSL1

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17981135


    NSL1 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    M Phase1.00
    Mitotic Anaphase0.85
    Mitotic M-M/G1 phases0.88
    Separation of Sister Chromatids0.80
    Mitotic Metaphase and Anaphase0.85
    2Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion1.00
    Mitotic Prometaphase0.93
    Kinetochore assembly0.96
    3Cell Cycle
    Cell Cycle1.00
    Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/10        Reactome Pathways for NSL1 (see all 10)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase
    Cell Cycle



    NSL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NSL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/86 Interacting proteins for NSL1 (Q96IY13 ENSP000003559444) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MIS12Q9H0813, ENSP000003705574I2D: score=4 STRING: ENSP00000370557
    DSN1Q9H4103, ENSP000003628504I2D: score=3 STRING: ENSP00000362850
    ZWINTO952293, ENSP000003630554I2D: score=2 STRING: ENSP00000363055
    BUB1O436833, ENSP000003025304I2D: score=2 STRING: ENSP00000302530
    CBX5P459733, ENSP000002098754I2D: score=4 STRING: ENSP00000209875
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087M phase of mitotic cell cycle TAS--
    GO:0000236mitotic prometaphase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation IEA--
    GO:0051301cell division IEA--


    NSL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NSL1
    Search CenterWatch for drugs/clinical trials and news about NSL1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for NSL1 gene (2 alternative transcripts): 
    NM_001042549.1  NM_015471.3  

    Unigene Cluster for NSL1:

    NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)
    Hs.497692  [show with all ESTs]
    Unigene Representative Sequence: NM_001042549
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366978 ENST00000366977(uc001hjm.3 uc001hjn.3 uc010pti.2)
    ENST00000366976 ENST00000473995 ENST00000487995 ENST00000366975 ENST00000422588


    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat NSL1
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate NSL1 (see all 47):
    hsa-miR-579 hsa-miR-323-3p hsa-miR-607 hsa-miR-642a hsa-miR-578 hsa-miR-550a* hsa-miR-3667-5p hsa-miR-3161
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NSL1 (see all 7)
    OriGene shRNA RFP: NSL1
    OriGene siRNA: NSL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NSL1
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NSL1 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NSL1 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): NSL1 (NM_015471)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for NSL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSL1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NSL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NSL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NSL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NSL1

    Additional cDNA sequence: 

    AF201941.1 AF255793.1 AK092359.1 AK124596.1 AK222996.1 AK223260.1 AK303250.1 AK313730.1 
    AL050084.1 BC007067.1 BC036048.1 

    19 DOTS entries:

    DT.454526  DT.92444149  DT.92444143  DT.307964  DT.101979802  DT.92444151  DT.121392590  DT.75125990 
    DT.75162347  DT.95103541  DT.100647874  DT.75101377  DT.92444142  DT.92444144  DT.95084242  DT.95084243 
    DT.99967484  DT.40222289  DT.92444152 

    24/150 AceView cDNA sequences (see all 150):

    AA746075 AA856553 BU077762 BE738948 BQ023978 BG493146 BQ068485 BX097965 
    BU077551 BM786567 BE501789 AI203449 AI648537 BF056313 CB960500 BG505418 
    AI745255 CK003923 AA086065 BU783840 BU570983 BG503163 BU784109 BG503949 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NSL1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e
    SP1:              -           -           -                                                   
    SP2:              -           -           -           -                                       
    SP3:              -           -           -           -     -                                 
    SP4:              -     -     -           -           -                                       
    SP5:              -           -           -     -     -                                       


    ECgene alternative splicing isoforms for NSL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    NSL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGCCAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See NSL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for NSL1

    SOURCE GeneReport for Unigene cluster: Hs.497692
        SABiosciences Custom PCR Arrays for NSL1
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NSL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat NSL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NSL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NSL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for NSL1 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Nsl11 , 5 NSL1, MIND kinetochore complex component, homolog (S. more1, 5 75.36(n)1
    67.5(a)1
      1 (96.28 cM)5
    3813181  NM_198654.31  NP_941056.31 
     1910630125 
    chicken
    (Gallus gallus)
    Aves NSL11 NSL1, MIND kinetochore complex component, homolog (S. more 60.18(n)
    47.47(a)
      421367  NM_001044646.1  NP_001038111.1 
    lizard
    (Anolis carolinensis)
    Reptilia NSL16
    --
    37(a)
    1 ↔ 1
    1(238676685-238696262)
    zebrafish
    (Danio rerio)
    Actinopterygii nsl11 NSL1, MIND kinetochore complex component, homolog (S. more 49.29(n)
    36.17(a)
      562522  NM_001025521.2  NP_001020692.1 


    ENSEMBL Gene Tree for NSL1 (if available)
    TreeFam Gene Tree for NSL1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1243 NCBI SNPs in NSL1 are shown (see all 1243    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1918204601,2
    --212898998(+) AACCAC/GAGACC 2 -- ds50010--------
    rs1428426521,2
    --212899004(+) AGACCC/TTTGTT 2 -- ds50010--------
    rs1465147841,2
    --212899013(+) TTCACA/TTGTTT 2 -- ds50010--------
    rs2003257821,2
    --212899051(+) CCTAT-/GACCCTG 2 -- ds50010--------
    rs636528631,2
    C,--212899182(+) TTTTTT/AAAAAA 2 -- ds50011Minor allele frequency- A:0.00WA 2
    rs344506501,2
    C,--212899183(+) TTTTAA/TAAAAA 2 -- ds50010--------
    rs788169181,2
    F,--212899299(+) CAACAG/AGATAT 2 -- ds50011Minor allele frequency- A:0.10WA 118
    rs127509281,2
    C--212899461(+) GCAGCA/CCGGTA 2 -- ds50010--------
    rs730799001,2
    C,--212899514(+) TATTCG/TATTTT 2 -- ut312Minor allele frequency- T:0.04WA 120
    rs120477971,2
    --212899531(+) TGAAAA/GATGCA 2 -- ut31 ese30--------

    HapMap Linkage Disequilibrium report for NSL1 (212899495 - 212965139 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for NSL1
         2 CNVs: 2347 5551

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NSL1
    DNA2.0 Custom Variant and Variant Library Synthesis for NSL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NSL1 for disorders           About MalaCards

    NSL1 for disorders           About GeneDecksing

    OMIM gene information: 609174    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: NSL1 (1 document)

    Export disorders for NSL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for NSL1 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with NSL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. (PubMed id 17981135)1, 2 Kiyomitsu T.... Yanagida M. (2007)
    2. The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation. (PubMed id 16585270)1, 2 Kline S.L.... Desai A. (2006)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. (PubMed id 15502821)1, 2 Obuse C....Yanagida M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Protein interaction domain mapping of human kinetocho re protein Blinkin reveals a consensus motif for binding of spindle assembly ch eckpoint proteins Bub1 and BubR1. (PubMed id 21199919)1 Kiyomitsu T....Yanagida M. (2011)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    10. Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes. (PubMed id 20231385)1 Kiyomitsu T....Yanagida M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25936 HGNC: 24548 AceView: DC8 Ensembl:ENSG00000117697 euGenes: HUgn25936
    ECgene: NSL1 H-InvDB: NSL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for NSL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for NSL1 gene:
    Search GeneIP for patents involving NSL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for NSL1   OriGene shRNA RFP for NSL1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for NSL1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for NSL1  
     OriGene Protein Over-expression Lysate for NSL1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for NSL1   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for NSL1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for NSL1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for NSL1   OriGene Custom Protein Services for NSL1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat NSL1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing NSL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat NSL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat NSL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat NSL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat NSL1
     GenScript Custom Purified and Recombinant Proteins Services for NSL1 GenScript cDNA clones with any tag delivered in your preferred vector for NSL1
     GenScript Custom Assay Services for NSL1 GenScript Custom Superior Antibodies Services for NSL1
     GenScript Custom overexpressing Cell Line Services for NSL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NSL1 promoter
     Search Chromatin IP Primers for NSL1
     RT2 qPCR Primer Assay in human, mouse, rat NSL1
     Search GNC Networks for NSL1
     SABiosciences Custom PCR Arrays for NSL1
     Search Tocris compounds for NSL1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     NSL1 antibodies
     NSL1 proteins
     NSL1 lysates
     Search for Antibodies for NSL1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for NSL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     NSL1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for NSL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for NSL1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for NSL1
     SwitchGear Promoter luciferase reporter plasmids for NSL1
     ThermoFisher Antibodies for NSL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat NSL1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      NSL1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4