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Aliases for NSG2 Gene

Aliases for NSG2 Gene

  • Neuronal Vesicle Trafficking Associated 2 2 3
  • Neuron-Specific Protein Family Member 2 3 5
  • Calcyon Family Member 3 2 3
  • Protein P19 3 4
  • HMP19 3 4
  • Hypothalamus Golgi Apparatus Expressed 19 KDa Protein 3
  • P19 Protein 3
  • HGNC:24955 5
  • CALY3 3

External Ids for NSG2 Gene

Summaries for NSG2 Gene

GeneCards Summary for NSG2 Gene

NSG2 (Neuronal Vesicle Trafficking Associated 2) is a Protein Coding gene. An important paralog of this gene is NSG1.

Additional gene information for NSG2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NSG2 Gene

Genomics for NSG2 Gene

Regulatory Elements for NSG2 Gene

Enhancers for NSG2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H173940 1.4 Ensembl ENCODE dbSUPER 19.7 -101.1 -101123 7 FOXA2 ATF1 MLX ARID4B DMAP1 SP5 JUNB PPARG KAT8 NFIL3 NSG2 C5orf47 BOD1 ENSG00000253244 LINC01485 GC05M173953 CPEB4
GH05H174311 1.3 FANTOM5 Ensembl ENCODE 16.4 +266.3 266311 1 CTCF MXI1 RB1 BACH1 RAD21 ZNF121 ZFHX2 POLR2A PATZ1 SMC3 NSG2 ENSG00000253244 BOD1 LOC102724551 ENSG00000249722 LOC105377737
GH05H173883 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -157.3 -157339 10 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 CREBRF NSG2 CPEB4 PIR46909
GH05H173788 1.5 Ensembl ENCODE dbSUPER 10.3 -255.8 -255830 2 PKNOX1 FOXA2 ARID4B DMAP1 YY1 SLC30A9 FOS ATF7 RUNX3 ZC3H11A CREBRF NSG2 LINC01485 LINC01484
GH05H173922 1.5 Ensembl ENCODE dbSUPER 9.9 -120.9 -120915 4 PKNOX1 FEZF1 ZNF2 ZNF121 ZNF143 ATF7 KLF7 TSHZ1 REST ZNF610 C5orf47 BOD1 NSG2 GC05M173953 CPEB4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around NSG2 on UCSC Golden Path with GeneCards custom track

Genomic Location for NSG2 Gene

Chromosome:
5
Start:
174,045,604 bp from pter
End:
174,243,501 bp from pter
Size:
197,898 bases
Orientation:
Plus strand

Genomic View for NSG2 Gene

Genes around NSG2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NSG2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NSG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NSG2 Gene

Proteins for NSG2 Gene

  • Protein details for NSG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y328-NSG2_HUMAN
    Recommended name:
    Neuron-specific protein family member 2
    Protein Accession:
    Q9Y328
    Secondary Accessions:
    • B2R5Y0
    • D3DQN0
    • Q9UHX8

    Protein attributes for NSG2 Gene

    Size:
    171 amino acids
    Molecular mass:
    19085 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NSG2 Gene

Post-translational modifications for NSG2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NSG2 Gene

No data available for DME Specific Peptides for NSG2 Gene

Domains & Families for NSG2 Gene

Gene Families for NSG2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NSG2 Gene

Suggested Antigen Peptide Sequences for NSG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y328

UniProtKB/Swiss-Prot:

NSG2_HUMAN :
  • Belongs to the NSG family.
Family:
  • Belongs to the NSG family.
genes like me logo Genes that share domains with NSG2: view

Function for NSG2 Gene

Phenotypes From GWAS Catalog for NSG2 Gene

Gene Ontology (GO) - Molecular Function for NSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032051 clathrin light chain binding IBA --
genes like me logo Genes that share ontologies with NSG2: view
genes like me logo Genes that share phenotypes with NSG2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NSG2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NSG2 Gene

Localization for NSG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NSG2 Gene

Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Endosome, multivesicular body membrane; Single-pass type II membrane protein. Note=Mainly Golgi stack, but also found in small vacuolar organelles and multivesicular bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NSG2 gene
Compartment Confidence
endosome 4
golgi apparatus 3
peroxisome 2
cytosol 2
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
GO:0030659 cytoplasmic vesicle membrane IEA --
genes like me logo Genes that share ontologies with NSG2: view

Pathways & Interactions for NSG2 Gene

No Data Available

Interacting Proteins for NSG2 Gene

Gene Ontology (GO) - Biological Process for NSG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007212 dopamine receptor signaling pathway IEA --
GO:0016197 endosomal transport IBA --
GO:0048268 clathrin coat assembly IBA --
genes like me logo Genes that share ontologies with NSG2: view

No data available for Pathways by source and SIGNOR curated interactions for NSG2 Gene

Drugs & Compounds for NSG2 Gene

No Compound Related Data Available

Transcripts for NSG2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for NSG2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for NSG2 Gene

No ASD Table

Relevant External Links for NSG2 Gene

GeneLoc Exon Structure for
NSG2
ECgene alternative splicing isoforms for
NSG2

Expression for NSG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Evidence on tissue expression from TISSUES for NSG2 Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with NSG2: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NSG2 Gene

Orthologs for NSG2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NSG2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 34
  • 100 (a)
OneToOne
HMP19 33
  • 94.35 (n)
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToOne
LOC462279 33
  • 100 (n)
cow
(Bos Taurus)
Mammalia NSG2 34
  • 99 (a)
OneToOne
HMP19 33
  • 93.76 (n)
mouse
(Mus musculus)
Mammalia Nsg2 33 16 34
  • 91.03 (n)
rat
(Rattus norvegicus)
Mammalia Nsg2 33
  • 90.64 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 34
  • 78 (a)
OneToOne
LOC416212 33
  • 76.22 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hmp19 33
  • 73.92 (n)
zebrafish
(Danio rerio)
Actinopterygii hmp19 34 33
  • 72.9 (n)
OneToOne
zgc73142 33
Species where no ortholog for NSG2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NSG2 Gene

ENSEMBL:
Gene Tree for NSG2 (if available)
TreeFam:
Gene Tree for NSG2 (if available)

Paralogs for NSG2 Gene

Paralogs for NSG2 Gene

(4) SIMAP similar genes for NSG2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NSG2: view

Variants for NSG2 Gene

Sequence variations from dbSNP and Humsavar for NSG2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000007583 -- 174,049,708(+) TGTGG(C/G)TCAAC intron-variant
rs1000012265 -- 174,089,415(+) GTGTA(-/T)TTTTT intron-variant, upstream-variant-2KB
rs1000025884 -- 174,076,022(+) CCTGA(A/G)CCCAG intron-variant
rs1000026386 -- 174,047,040(+) CCAAG(A/G)CATCT intron-variant
rs1000040007 -- 174,053,201(+) TACCT(C/T)AGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NSG2 Gene

Variant ID Type Subtype PubMed ID
dgv113n17 CNV loss 16327808
esv1477078 CNV deletion 17803354
esv2731129 CNV deletion 23290073
esv2731130 CNV deletion 23290073
esv2731131 CNV deletion 23290073
esv3413399 CNV duplication 20981092
esv990876 CNV deletion 20482838
nsv5137 CNV deletion 18451855
nsv600298 CNV gain 21841781

Variation tolerance for NSG2 Gene

Residual Variation Intolerance Score: 23.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for NSG2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NSG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NSG2 Gene

Disorders for NSG2 Gene

Relevant External Links for NSG2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NSG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NSG2

No disorders were found for NSG2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NSG2 Gene

Publications for NSG2 Gene

  1. Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking. (PMID: 25376768) Muthusamy N … Bergson C (Journal of neurochemistry 2015) 2 3 60
  2. A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. (PMID: 15383276) Goehler H … Wanker EE (Molecular cell 2004) 2 3 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 60
  5. A 19-kDa protein belonging to a new family is expressed in the Golgi apparatus of neural cells. (PMID: 7829526) Sabéran-Djoneidi D … Lévi-Strauss M (The Journal of biological chemistry 1995) 2 3 60

Products for NSG2 Gene

Sources for NSG2 Gene

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